CN101757598A - Traditional Chinese medicine composition for treating advanced malignant liver tumor symptoms and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating advanced malignant liver tumor symptoms and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a new traditional Chinese medicine composition for treating advanced malignant liver tumor symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: angelica, tuckahoe, hemlock parsley, cassia twig, dried ginger, Bupleurum, kudzu root, Baikal skullcap root, coptis, flavescent sophora root, honeysuckle, Taraxacum, pangolin, leech, natural indigo, subprostrate sophora, moutan bark, red-rooted salvia root, red paeonia, white peony root, white atractylodes rhizome, gromwell, cornu antelopis powder, rhubarb, magnolia bark, three-nerved spicebush root, notoginseng, madder, draconis sanguis, rhizoma corydalis, raw Astragalus root, codonopsis pilosula, peach seed, safflower, turmeric, Endothelium Corneum Gigeriae Galli, Fructus Aurantii Immaturus, Polyporus umbellatus, rhizoma alismatis, Plantain seed, climbing fern spore, giant knotweed, Evodia rutaecarpa, nut grass, galangal and allium macrostemon. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the intense pain, obstructs the canceration of liver tumor cells, interdicts the reproduction of tumor cells, recovers the activity of liver cells, enhances the self-repairing function of the liver, resists the diffusion and prevent the metastasis, obviously shrinks the liver tumors, relieves and eliminates the ascites, improves the life quality, prolongs the life, relieves patient's pain and increases the appetite. The traditional Chinese medicine composition has exact and obvious clinical curative effect of improving the overall disease resistance.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of advanced malignant liver tumor symptoms.Relating in particular to a kind of is the Chinese medicine composition and preparation method thereof of the treatment advanced malignant liver tumor symptoms of crude drug with the Chinese herbal medicine.
Background technology
According to epidemiologic data, the M ﹠ M of China's advanced malignant liver tumor accounts for the 3rd of whole malignant tumor, and human health in serious harm, is one of common malignancy.Factors such as viral hepatitis, pollution of waterhead, chemical carcinogen, gene mutation, overnutrition or malnutrition, parasitic infection and heredity all very easily cause the generation of advanced malignant liver tumor disease.As not controlled timely and effectively and being treated, often cause that digestive tract hemorrhage, hepatocarcinoma tuberosity break, liver failure, infection etc., these complication cause the immediate cause of PLC mortality often, and the clinical onset rate has the trend of continuous rising in recent years.
At present in the Therapeutic Method of liver malignancy, the late result of early stage excision is better, but Most patients has belonged to late period when making a definite diagnosis, surgical engine can many miss, and chemicotherapy is big to the toxicity of primary disease treatment, curative effect is also poor, in order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines, treating both the principal and secondary aspects of a disease of Chinese traditional treatment advanced malignant liver tumor symptoms, deficiency and excess is also controlled, inside and outside logical the accent, emergency is taken in concurrently, filters out depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, the natural plant of removing food stagnancy eliminating stagnation, according to the theory of Chinese medical science prescription, be prepared from according to certain weight proportion.A kind of Chinese medicine composition of evident in efficacy, with low cost, treatment advanced malignant liver tumor symptoms that toxic and side effects is minimum is provided.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be: pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is assorted to overcome above-described shortcoming, and a kind of Chinese medicine composition of treatment advanced malignant liver tumor symptoms of evident in efficacy, with low cost, almost non-toxic side effect is provided.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of Chinese medicine composition for the treatment of advanced malignant liver tumor symptoms of the present invention, the component of main following weight portion is formed:
Radix Angelicae Sinensis 1～150 gram, Poria 1～150 gram, Rhizoma Chuanxiong 1～50 gram, Ramulus Cinnamomi 1～100 gram, Rhizoma Zingiberis 1～150 gram, Radix Saposhnikoviae 1～50 gram, Rhizoma Et Radix Notopterygii 1～50 gram, Radix Bupleuri 1～100 gram, Radix Puerariae 1～150 gram, Flos Chrysanthemi 1～50 gram, Radix Scutellariae 1～50 gram, Rhizoma Coptidis 1～50 gram, Radix Sophorae Flavescentis 1～150 gram, Radix Gentianae 1～150 gram, Flos Lonicerae 1～100 gram, Herba Taraxaci 1～150 gram, Squama Manis 1～50 gram, Hirudo 1～50 gram, Tabanus 1～50 gram, Herba Andrographis 1～50 gram, Folium Isatidis 1～100 gram, Indigo Naturalis 1～50 gram, Rhizoma Osmundae 1～50 gram, Radix Sophorae Tonkinensis 1～150 gram, Radix Rehmanniae 1～50 gram, Cortex Moutan 1～100 gram, Radix Salviae Miltiorrhizae 1～50 gram, Radix Paeoniae Rubra 1～50 gram, the Radix Paeoniae Alba 1～100 gram, the Rhizoma Atractylodis Macrocephalae 1～100 gram, Radix Arnebiae (Radix Lithospermi) 1～150 gram, Cornu Saigae Tataricae powder 1～30 gram, Radix Et Rhizoma Rhei 1～100 gram, Fructus Crotonis 1～50 gram, Radix Aconiti 1～50 gram, Radix Stephaniae Tetrandrae 1～50 gram, Cortex Magnoliae Officinalis 1～150 gram, Massa Medicata Fermentata 1～300 gram, Fructus Crataegi 1～50 gram, the Radix Linderae 1～100 gram, Semen Raphani 1～100 gram, Radix Notoginseng 1～50 gram, Radix Rubiae 1～150 gram, Sanguis Draxonis 1～50 gram, Pericarpium Arecae 1～100 gram, Rhizoma Corydalis 1～100 gram, Radix Astragali 1～150 gram, Radix Codonopsis 1～100 gram.
Be preferably:
Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams.
The weight portion consumption of each component of Chinese medicine composition of the present invention can also be:
Semen Persicae 1～50 gram, Flos Carthami 1～50 gram, rhizoma sparganic 1～50 gram, Rhizoma Curcumae 1～50 gram, Radix Curcumae 1～50 gram, Endothelium Corneum Gigeriae Galli 1～100 gram, Pericarpium Citri Reticulatae Viride 1～100 gram, Fructus Aurantii Immaturus 1～150 gram, Herba Lysimachiae 1～100 gram, Polyporus 1～50 gram, Rhizoma Alismatis 1～100 gram, Semen Coicis 1～150 gram, Semen Plantaginis 1～100 gram, Spora Lygodii 1～100 gram, Rhizoma Polygoni Cuspidati 1～100 gram, Cortex Cinnamomi 1～50 gram, Fructus Evodiae 1～50 gram, Fructus Aurantii 1～50 gram, Rhizoma Cyperi 1～100 gram, Folium Perillae 1～50 gram, Rhizoma Alpiniae Officinarum 1～50 gram, Bulbus Allii Macrostemonis 1～50 gram, Flos Caryophylli 1～50 gram, Pericarpium Zanthoxyli 1～50 gram.
Be preferably:
Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Polyporus 50 grams, Rhizoma Alismatis 30 grams, Semen Coicis 50 grams, Semen Plantaginis 30 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Cortex Cinnamomi 20 grams, Fructus Evodiae 20 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams, Folium Perillae 20 grams, Rhizoma Alpiniae Officinarum 30 grams, Bulbus Allii Macrostemonis 30 grams, Flos Caryophylli 20 grams, Pericarpium Zanthoxyli 20 grams.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese medicine composition of the present invention is opened one's minds based on traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, in conjunction with safe one and Pu innovation theory system " ten thousand diseases ascent theory ", " the five internal organs differentiation of syndromes of YIN and YANG guiding principle ", " three-dimensional conservation regulation and control rule " and clinical treatment " pairing principle " are as instructing, take place in conjunction with disease, development and the rule that changes, classify according to the original new drug system, formation is monarch with " the five internal organs basic function is adjusted; equilibrium between yin and yang coordination side ", " the main pathogenesis of the five internal organs adjustment side " is minister, " therapy of serious disease side " is assistant, " clinical fundamental symptoms symptomatic treatment side " Chinese medicine patent medicine " original new drug system " for making.This is the important content of Thailand one and Pu (Beijing) Chinese medicine academy patent strategy.
The structure of Thailand one and Pu patent strategy is convenient to Chinese medicine and is realized standardization, scale, industrialization, modernization and industrialization.For traditional Chinese medicine development has been opened up a road that meets the Chinese medicine self-law with innovation.The used herbal raw material medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: for oral administration: 1) capsule: obey 2～5 every day three times at every turn, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The treatment that the present invention is directed to the advanced malignant liver tumor symptoms patient is very effective, various crude drug are coordinated mutually can play together and are at utmost brought into play drug effect, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never are limited to the present invention.
The preparation of [embodiment 1] capsule
Take by weighing each raw material by following weight portion: Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams, Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams.
Grind into after each component mixing with above-mentioned weight and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each raw material by following weight portion: Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams, Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams.
Each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
The preparation of [embodiment 3] tablet
Take by weighing each raw material according to following weight portion: Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams, Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams.
Each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
The preparation of [embodiment 4] pill
Take by weighing each raw material according to following weight portion: Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams, Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams.
Each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material according to following weight portion: Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams, Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams.
Each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into rule
Fixed concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
[experimental example] traditional Chinese medicine composition for treating advanced malignant liver tumor symptoms of the present invention patient's clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 145 routine patients altogether, wherein male 81 examples, women 64 examples; The oldest person 79 years old, the age reckling has only 24 years old.
Therapeutic Method:
Usage and dosage: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: obey 2～5 every day three times at every turn, and every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats for 10 courses of treatment altogether.
The therapeutic evaluation standard
Cure: sign is improved fully, and the patient does not have any bad sensation, and is happy, in high spirits.
Produce effects: sign is significantly improved, and the patient does not have bad sensation substantially, and is happy, and spirit is fine.
Effectively: sign obviously changes, and random thoughts have discomfort slightly, but can accept, and mood is better, and energy is more abundant.
Invalid: sign does not have any change, and symptom such as preceding feels depressed, and lethargy is depressed.
Model case:
1, Shao so-and-so, man, 46 years old, cadre.Epigastrium enclosed mass 2 months, companion's abdominal part poor appetite, gastral cavilty is full, and have a pain in the hepatic region, oliguria with reddish urine, xerostomia epistaxis, liver radioisotope scan shows before January: huge space-occupying lesion in the liver, ascites (++), α-FP750 unit is diagnosed as advanced malignant liver tumor.2 bottles of oral tegafurs (previously not having hepatitis history), conditions of patients day by day increases the weight of, and is ill-conditioned when examining, and the face ash is dim, emaciated physique, spiritlessness and weakness, the singultus belch, following 10 centimeters of hepatomegaly rib, following 14 centimeters of xiphoid-process, matter is hard, ascites (+++), two lower limb pitting edemas, the profound number of arteries and veins is sliding, yellowish fur.
Take Chinese medicine composition of the present invention after 15 days, conscious abdominal distention alleviates, and epistaxis is less, took Chinese medicine composition of the present invention again 3 months, edema of lower limbs disappears, hydrouria, spirit takes a turn for the better, abdominal distention alleviates, following 8 centimeters of hepatomegaly rib, following 10 centimeters of xiphoid-process, ascites (+), α-FP140 unit, continuous clothes Chinese medicine composition of the present invention 6 months, symptom is obviously improved, in high spirits, appetite is good, and liver obviously is contracted to following 3 centimeters of rib, following 5 centimeters of xiphoid-process, α-FP33 unit, do not see obvious space occupying lesion in the liver, stable disease continues treatment.
2, Yin, woman, 41 years old, accounting.
The patient hepatalgia often occurs from over 8 years, and companion's low grade fever (37.5～38 ℃), and hospital makes liver puncture, doubts and examines hepatitis." flu " heating before half a year, hepatalgia the soldier so increase the weight of, and is prickling-like pain, examines on inspection to be advanced malignant liver tumor, hospitalization.Through handling in many ways, low grade fever, hepatalgia fail to improve all the time, the whole body situation also worsens day by day, when examining, hepatalgia, low grade fever (37.5 ℃), flatulence, poor appetite, loose stool, shape is thin, greenish complexion is dark, Mental fatigue is breathed hard, deep-thready pulse stringy and rapid pulse, body of the tongue green grass or young crops are red, ecchymosis, white and thin fur are arranged, following 5 centimeters of palpation of liver rib, and matter is hard, rough, touch a tender spot.
Take Chinese medicine composition of the present invention after 15 days, hepatalgia day by day alleviates, and low grade fever disappears, took Chinese medicine composition of the present invention again 3 months, hepatalgia is significantly alleviated, and spirit takes a turn for the better, abdominal distention alleviates, and appetite increases, following 3 centimeters of hepatomegaly rib, continuous clothes Chinese medicine composition of the present invention 6 months, hepatalgia disappears substantially, and symptom is obviously improved, in high spirits, weight increase is had rosy cheeks, check: liver size, function are normal.
3, Huang, man, 39 years old, workman.
Did the cholelithiasis enucleation before 4 years, upper abdomen distension pain, indigestion and loss of appetite lack of appetite, beginning misidentification are gastropathy before January, and hospitalize is invalid, one all preceding hepatic region plays after being ill, breast hydrops censorship, cancerous cell (+), be diagnosed as advanced malignant liver tumor, rescued 28 days, sb.'s illness took a turn for the worse is exceedingly fast, and one's belly is tight as a drum, asthma can not be put down for sleeping in, severe pain requires to leave hospital through family members unbearably, and all funeral affairs are ready to.When examining, one's belly is tight as a drum for the patient, and lump is pressed umbilicus under the xiphoid-process, under the liver rib, and matter is hard, and the edge is not whole, and surperficial tuberosity is obvious, and the sound of kowtowing is real, and the lower abdomen succussion splash is obvious, deep red tongue, and yellow fur is deceived no Tianjin, coma asthma, stringy pulse flood band knot, two chi unrooteds, constipation.
Take Chinese medicine composition of the present invention after 2 days, refreshing clear, bitter taste in the mouth and dry throat, unable in a minute, black fur moves back slightly, oliguria with reddish urine, abdominal distention disappears soft, and two sides of body are felt bitterly, can put down for sleeping in slightly, took Chinese medicine composition of the present invention again 15, the hepatic region lump obviously dwindles, abdomen is soft can put down for sleeping in, can advance one bowl in gruel every day, stringy pulse is little, and irregularly intermittent pusle is separated slightly, black fur moves back, right side of body pain relief, stool every day 2 to 3 times, still black down sticking color stool, continuous clothes Chinese medicine composition of the present invention 20 days, right side of body hypodynia, the hepatic region lump disappears soft more than half, stomach is received amelioration, the defecation of oneself having got up, and every day, still black down sticking color stool was 1 to 2 time; it is little red to urinate; it is surplus June to obey Chinese medicine composition of the present invention again, and daily life is all normal, hospital's review result: AFP＞35mg/L; ultrasound wave; liver function is all normal, the healthy operate as normal life of patient 26 years.
4, the week so-and-so, woman, 40 years old, teacher.
The patient vomitted before 1 year because of stomach wrist lump companion pain and is diagnosed as gastric cancer through examination in hospital, and parallel stomach is cut art entirely, and February, the cause hepatalgia arrived examination in hospital, in the B ultrasonic prompting liver occupying lesion was arranged, and was diagnosed as the transitivity advanced malignant liver tumor.Ultrasonic finding: outer section of left liver and inner edge are all seen low echo area, are respectively 0.2cm X 2.1cm, 3.0cm X 2.9cm size, and the border is still clear, right liver echo is even, shows no obvious abnormalities the district, and the conscious right side of body of patient is the distension discomfort down, a burst ofly have a pain, vexed irritability, the dream of sleeping night is many, dry mouth and throat, red tongue is thin, tongue Bai Ergan, right stringy pulse is fine and smooth, left stringy and thready pulse.
Take Chinese medicine composition of the present invention after 20 days, the side of body gradually comfortable, pain down greatly alleviates, took Chinese medicine composition of the present invention again 3 months, pain disappears substantially, check B ultrasonic prompting: liver left side internal lobe see 1.3cm X 1.2cm hang down echo group, sharpness of border rule, surplus echo can, ultrasonic prompting: left intrahepatic leaf hole space occupying lesion, continuous clothes Chinese medicine composition of the present invention 6 months, all transference cures, health gets stronger and stronger, check, ultrasonic prompting: echo is even in the liver, and blood vessel is clear, show no obvious abnormalities, follow up a case by regular visits to two every year normally.
5, Feng, man, 58 years old, peasant.
The patient is plain to suffer from surplus the hepatitis B 10 year, and nearly March, the hepatic region continued dull pain, and right rib is along the lump of finding goose ovum size down, and the matter of touching is hard, is uneven, and B ultrasonic is looked into and seen: a plurality of similar round nodositas of the right back leaf of liver echo, about 107mm * 86mm; 51mm * 45mm, the lump periphery is clear, irregularity, the internal echo skewness, big person is strong echo, and CDFI and CPA demonstration lump periphery are seen mottled color stream, see in the lump and enrich blood vessel.Ultrasonic prompting: the multiple massive type occupying lesion of right liver (hepatocarcinoma).Be diagnosed as advanced malignant liver tumor through above inspection.Examine and see emaciated physique, darkish complexion, red tongue with yellow fur is thick, the deep pulse stringy and rolling pulse; Can touch the lump of a goose ovum size under the right rib edge, matter is hard, and the surface is uneven; The abdominal part softness, strike as tympanitic resonance, conscious weak, the low grade fever, indigestion and loss of appetite, the gastral cavity belly stay expands, continuous dull pain is abducted on the right side, stool slightly does.
Take Chinese medicine composition of the present invention after January, symptom is significantly improved, and takes Chinese medicine composition of the present invention again 3 months, abdominal distention, low grade fever disappears, appetite is promoted, and spirit is clearly better, during once recovered work, all there is not significant discomfort, continuous clothes Chinese medicine composition of the present invention 6 months, the B ultrasonic check shows: right lobe of liver is covered with low echo enclosed mass, 91 maximum * 63cm, the border is clear, liver blood vessel is owed clearly, the Glisson's capsule irregularity, and B ultrasonic check finding: the lump size is examined to compare obviously with head and is dwindled, and all cards take a turn for the better, the patient is filled with unbounded confidence more to treatment, obeys Chinese medicine composition of the present invention again 3 months, fades away in right rib edge enclosed mass down, subjective symptoms is clearly better, the B ultrasonic check: the lump echo that the visible form of right lobe of the liver is irregular, the most about 71mm * 64mm, the visible sound of periphery is dizzy, interior echo is inhomogeneous, portal vein broadening, about 14mm are owed clearly in the blood vessel demonstration in the liver, interior echo is still even, does not see lump echo.
6, Lee so-and-so, man 60 years old, the retired cadre.
Before January because of poor appetite, detest greasy health check-up, hospital is diagnosed as on inspection: constitutional advanced malignant liver tumor, three swollen things of left liver, 6.0 * 5.0cm, 2.9 * 3.1cm, 2.5 * 2.6cm; 7.5 * 4.1cm of right liver.Participate in chemotherapy in hospital once, cause mental weariness, can't be free movable, ochriasis is dark and gloomy when examining, shortness of breath and tired spirit, poor appetite splits in the pale purple indentation of enlarged tongue, and tongue is greasy in vain, and tongue limit ecchymosis is in blocks, faint and thready pulse and urgency, 120 times/minute.
Take Chinese medicine composition of the present invention after 10 days, spirit takes a turn for the better, and appetite increases, and takes Chinese medicine composition of the present invention again 1 month, B ultrasonic is looked into and seen: the swollen thing of right liver slightly dwindles, the swollen thing of left side liver slightly increases 2 kilograms of weight increase, faint and thready pulse, 100 times/minute, continuous clothes Chinese medicine composition of the present invention 2 months can arbitrarily be taken action, and has not had sickly complexion, the confidence of taking medicine heightens, patient's spirit muscle power continues to take a turn for the better, can be by bike 10 kilometers and tired, it is surplus June to take Chinese medicine composition of the present invention again, ultrasound diagnosis: the no abnormal discovery of left liver, the swollen thing of right liver is contracted to 3.0 * 2.5cm, and 2.4 * 2.1cm continues treatment.
7, journey so-and-so, woman, 49 years old, accounting.
Because of abdominal distention and pain, defecate every day 8 to 10 times before 3 years, examination in hospital, laparotomy exploration see that rectum epimere cancerous protuberance soaks into diffusion towards periphery, and check pathological section is diagnosed as rectal adenocarcinoma, makes sigmoid colon and anastomosis of rectum, in conjunction with chemotherapy.In November, 1993 liver pain aggravation, indigestion and loss of appetite lack of appetite, wasting, limbs fatigue is checked to hospital, and the B ultrasonic report is shown: liver section luminous point skewness, lobus dexter is seen 4.8 * 3.8cm tuberosity, see 5.1cm * 3.6cm essence lump in hepatic hilar region, tuberosity in the prompting lobus dexter liver, CT examination: the epigastrium CT scan is seen hepatic portal place occupancy low-density focus, density unevenness is even, right lobe of liver, quadrate lope nodosity shape low-density kitchen range in addition exist, and are a plurality of tuberositys, the common hepatic duct expansion.Diagnosis: the transitivity advanced malignant liver tumor, patient and family members completely lose confidence, and sb.'s illness took a turn for the worse is exceedingly fast, the aggravation of liver pain abdominal distention.
Take Chinese medicine composition of the present invention after 1 month, the black stool is 2 to 3 times under every day, and the liver abdominal lump disappears soft, alleviation of pain, stomach is received amelioration, and every meal can advance two bowls in gruel, and life can be taken care of oneself, patient and family members are full of confidence, continuous clothes Chinese medicine composition of the present invention 2 months, and every day, black down sticking color stool was 1 to 2 time, the liver abdominal lump disappears soft more than half, and pain is light, and daily life is normal substantially, weight increase, can do a little housework, take Chinese medicine composition of the present invention again 3 months, black sticking stool is few, right costalgia is ended, appetite is greater than Chang Ri, and more than ten jin of weight increase touches about one under the right side of body and refer to the position, matter is soft, mild tenderness, daily life is normal, and it is surplus March to take Chinese medicine composition of the present invention again, check liver size, function is all normal, followed up a case by regular visits to 2 years, the state of an illness does not have repeatedly, and daily life is normal.
8, execute so-and-so, woman, 37 years old, office worker.
Patient's dull pain under the conscious right front aft rib before 2 years, increase the weight of gradually, the ultrasonic examination right lobe of liver is visited and the strong slightly echo district of 10.1 * 10.7cm, and CT shows: right lobe of liver has one huge shadow occupy-place, and liver function has certain infringement, be diagnosed as the constitutional advanced malignant liver tumor, after after the liver protecting and ALT lowering treatment, change oncology and get involved chemotherapy, get involved through 2 times, abdominal distention, diarrhoea, poor appetite occur, become thin, liver function injury is heavier, at this moment the patient refuses interventional therapy once more.When examining, it is flat that the patient coerces down swollen thing and umbilicus, as hard as flint, hypnalgia very, vexed irritability, night unable to fall asleep, xerostomia is thirsty, red tongue, Shao Jin, thready and rapid pulse.
Take Chinese medicine composition of the present invention after 1 month, liver abdominal lump soft, the alleviation of pain that disappears, diet, sleep amelioration, life can be taken care of oneself, continuous clothes Chinese medicine composition of the present invention 3 months, and check CT shows: huge shadow occupy-place of right lobe of liver obviously dwindled, daily life is normal substantially, weight increase, hepatalgia alleviates, stable disease, can finish part housework, take Chinese medicine composition of the present invention June again, aft rib pain down ends weight increase, check CT shows: huge shadow occupy-place of right lobe of liver disappears, liver size, function are all normal, and the state of an illness does not have repeatedly, resumes work.
Five, therapeutic outcome:
In the 145 routine cases of being accepted for medical treatment,, wherein cure 57 examples through treatment in 10 months, produce effects 39 examples, effective 43 examples, invalid 6 examples, total effective rate reaches 95%.The result shows that Chinese medicine composition of the present invention has extremely significant curative effect to treatment advanced malignant liver tumor symptoms patient.
Claims (7)
1. Chinese medicine composition for the treatment of advanced malignant liver tumor symptoms is characterized in that: mainly contain following bulk drugs and form:
Radix Angelicae Sinensis 1～150 gram, Poria 1～150 gram, Rhizoma Chuanxiong 1～50 gram, Ramulus Cinnamomi 1～100 gram, Rhizoma Zingiberis 1～150 gram, Radix Saposhnikoviae 1～50 gram, Rhizoma Et Radix Notopterygii 1～50 gram, Radix Bupleuri 1～100 gram, Radix Puerariae 1～150 gram, Flos Chrysanthemi 1～50 gram, Radix Scutellariae 1～50 gram, Rhizoma Coptidis 1～50 gram, Radix Sophorae Flavescentis 1～150 gram, Radix Gentianae 1～150 gram, Flos Lonicerae 1～100 gram, Herba Taraxaci 1～150 gram, Squama Manis 1～50 gram, Hirudo 1～50 gram, Tabanus 1～50 gram, Herba Andrographis 1～50 gram, Folium Isatidis 1～100 gram, Indigo Naturalis 1～50 gram, Rhizoma Osmundae 1～50 gram, Radix Sophorae Tonkinensis 1～150 gram, Radix Rehmanniae 1～50 gram, Cortex Moutan 1～100 gram, Radix Salviae Miltiorrhizae 1～50 gram, Radix Paeoniae Rubra 1～50 gram, the Radix Paeoniae Alba 1～100 gram, the Rhizoma Atractylodis Macrocephalae 1～100 gram, Radix Arnebiae (Radix Lithospermi) 1～150 gram, Cornu Saigae Tataricae powder 1～30 gram, Radix Et Rhizoma Rhei 1～100 gram, Fructus Crotonis 1～50 gram, Radix Aconiti 1～50 gram, Radix Stephaniae Tetrandrae 1～50 gram, Cortex Magnoliae Officinalis 1～150 gram, Massa Medicata Fermentata 1～300 gram, Fructus Crataegi 1～50 gram, the Radix Linderae 1～100 gram, Semen Raphani 1～100 gram, Radix Notoginseng 1～50 gram, Radix Rubiae 1～150 gram, Sanguis Draxonis 1～50 gram, Pericarpium Arecae 1～100 gram, Rhizoma Corydalis 1～100 gram, Radix Astragali 1～150 gram, Radix Codonopsis 1～100 gram.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that: the weight portion of each crude drug is:
Radix Angelicae Sinensis 100 grams, Poria 100 grams, Rhizoma Chuanxiong 30 grams, Ramulus Cinnamomi 50 grams, Rhizoma Zingiberis 30 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 20 grams, Radix Bupleuri 30 grams, Radix Puerariae 50 grams, Flos Chrysanthemi 30 grams, Radix Scutellariae 30 grams, Rhizoma Coptidis 20 grams, Radix Sophorae Flavescentis 30 grams, Radix Gentianae 50 grams, Flos Lonicerae 50 grams, Herba Taraxaci 60 grams, Squama Manis 20 grams, Hirudo 20 grams, Tabanus 20 grams, Herba Andrographis 20 grams, Folium Isatidis 40 grams, Indigo Naturalis 20 grams, Rhizoma Osmundae 30 grams, Radix Sophorae Tonkinensis 100 grams, Radix Rehmanniae 30 grams, Cortex Moutan 50 grams, Radix Salviae Miltiorrhizae 30 grams, Radix Paeoniae Rubra 30 grams, the Radix Paeoniae Alba 60 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Cornu Saigae Tataricae powder 10 grams, Radix Et Rhizoma Rhei 30 grams, Fructus Crotonis 20 grams, Radix Aconiti 20 grams, Radix Stephaniae Tetrandrae 30 grams, Cortex Magnoliae Officinalis 50 grams, Massa Medicata Fermentata 100 grams, Fructus Crataegi 30 grams, the Radix Linderae 30 grams, Semen Raphani 50 grams, Radix Notoginseng 30 grams, Radix Rubiae 60 grams, Sanguis Draxonis 10 grams, Pericarpium Arecae 50 grams, Rhizoma Corydalis 30 grams, Radix Astragali 50 grams, Radix Codonopsis 50 grams.
3. according to the described Chinese medicine composition of claim 1, wherein crude drug also has:
Semen Persicae 1～50 gram, Flos Carthami 1～50 gram, rhizoma sparganic 1～50 gram, Rhizoma Curcumae 1～50 gram, Radix Curcumae 1～50 gram, Endothelium Corneum Gigeriae Galli 1～100 gram, Pericarpium Citri Reticulatae Viride 1～100 gram, Fructus Aurantii Immaturus 1～150 gram, Herba Lysimachiae 1～100 gram, Polyporus 1～50 gram, Rhizoma Alismatis 1～100 gram, Semen Coicis 1～150 gram, Semen Plantaginis 1～100 gram, Spora Lygodii 1～100 gram, Rhizoma Polygoni Cuspidati 1～100 gram, Cortex Cinnamomi 1～50 gram, Fructus Evodiae 1～50 gram, Fructus Aurantii 1～50 gram, Rhizoma Cyperi 1～100 gram, Folium Perillae 1～50 gram, Rhizoma Alpiniae Officinarum 1～50 gram, Bulbus Allii Macrostemonis 1～50 gram, Flos Caryophylli 1～50 gram, Pericarpium Zanthoxyli 1～50 gram.
4. according to the described Chinese medicine composition of claim 3, wherein the weight portion of each component is:
Semen Persicae 20 grams, Flos Carthami 30 grams, rhizoma sparganic 20 grams, Rhizoma Curcumae 20 grams, Radix Curcumae 30 grams, Endothelium Corneum Gigeriae Galli 50 grams, Pericarpium Citri Reticulatae Viride 50 grams, Fructus Aurantii Immaturus 100 grams, Herba Lysimachiae 50 grams, Polyporus 50 grams, Rhizoma Alismatis 30 grams, Semen Coicis 50 grams, Semen Plantaginis 30 grams, Spora Lygodii 50 grams, Rhizoma Polygoni Cuspidati 50 grams, Cortex Cinnamomi 20 grams, Fructus Evodiae 20 grams, Fructus Aurantii 20 grams, Rhizoma Cyperi 30 grams, Folium Perillae 20 grams, Rhizoma Alpiniae Officinarum 30 grams, Bulbus Allii Macrostemonis 30 grams, Flos Caryophylli 20 grams, Pericarpium Zanthoxyli 20 grams.
5. according to claim 1,2,3 or 4 described any Chinese medicine compositions, it is characterized in that: can be prepared into any oral formulations commonly used according to the method for Chinese medicinal of routine.
6. according to the described Chinese medicine composition of claim 5, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
7. the application of the described any Chinese medicine composition of claim 1～6 in preparation treatment liver evil property in late period tumor disease medicine.
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