CN101757114A - Hypoglycemic product and preparation method thereof - Google Patents
Hypoglycemic product and preparation method thereof Download PDFInfo
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- CN101757114A CN101757114A CN200810154551A CN200810154551A CN101757114A CN 101757114 A CN101757114 A CN 101757114A CN 200810154551 A CN200810154551 A CN 200810154551A CN 200810154551 A CN200810154551 A CN 200810154551A CN 101757114 A CN101757114 A CN 101757114A
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- folium
- radix astragali
- fructus momordicae
- momordicae charantiae
- hypoglycemic
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Abstract
The invention aims to provide a hypoglycemic product and a preparation method thereof. The product comprises balsam pear powder, mulberry leaves, gingko leaves and astragalus. The weight parts of the components are as follows: 60-65 of balsam pear powder, 1-5 of gingko leaves, 23-28 of mulberry leaves and 9-13 of astragalus. Based on the special combination of natural Chinese herbs, the invention achieves the functions of preventing, improving and reducing blood sugar. The preparation method is simple, the process conditions are stable, and the invention is applicable to the large-scale industrial production.
Description
(1) technical field:
The present invention relates to a kind of product and preparation method thereof, especially a kind of hypoglycemic product and preparation method thereof.
(2) background technology:
Investigation of The World Health Organization (WHO) and IDF (IDF) shows that the diabetes death of society 80% at present occurs in low income and middle income country.Almost the diabetes death of half betides the people below 70 years old; 55% diabetes death betides the women.In following 10 years, if do not take urgent action, diabetes death will increase more than 50%.The diagnosis of diabetes foundation is blood glucose and clinical symptoms.The treatment of diabetes target is that blood sugar control makes it as far as possible near normal, and then reduces the generation and the development of the various acute and chronic complication of diabetes, improves the quality of life of ward mates, and the prerequisite that reaches this target is exactly good state of illness monitoring.Although medical circle obtains many progress to the research of treatment diabetes both at home and abroad, but relative chemical drugs is many, take the back and produce many side effect, and in the Chinese patent medicine goods also major part be Integrative Chinese-Western, therefore invent a kind of pure natural plant product, can effectively improve and treat diabetes and become the major issue that present stage needs to be resolved hurrily.
(3) summary of the invention:
The object of the present invention is to provide a kind of hypoglycemic product and preparation method thereof; described product reaches effective prevention, improves and hypoglycemic effect by natural Chinese medicinal herb is carried out specific combination, and its preparation method is simple; stable process conditions is fit to large-scale industrial production.
Technical scheme of the present invention: a kind of hypoglycemic product, comprise Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, its weight quota is than being Fructus Momordicae charantiae powder 60～65, Folium Ginkgo 1～5, Folium Mori 23～28, the Radix Astragali 9～13.
The preparation method of above-mentioned a kind of hypoglycemic product may further comprise the steps:
(1) gets Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali according to the above ratio respectively, remove foreign material, clean, dry;
(2), cross 80 to 120 mesh sieves with Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and Radix Astragali pulverize separately;
(3) powder mixes with above-mentioned pulverizing is even, is product.
The preparation method of above-mentioned a kind of hypoglycemic product can be made dosage forms such as capsule, tablet, pill, drop pill, electuary, syrup or decoction pieces with the product in the above-mentioned steps (3).
The preparation method of above-mentioned a kind of hypoglycemic product can be made medicine or health food.
The pharmacology analysis of prescription of the present invention:
Each component of the present invention is the material of integration of edible and medicinal herbs, wherein:
Fructus Momordicae charantiae, bitterness, cold in nature, its medical value Gu is on the books." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control red fire-toxin gas, treat malignant boil knot poison, or all overly become the Semen Sesami furuncle painful unbearably.Rush down the six channels excess-fire, clearing away summer-heat, QI invigorating is quenched the thirst." give birth to give birth to compile ": remove pathogenic heat, separate tiredly, clearing away heart-fire makes eye bright." book on Chinese herbal medicine is looked for the truth ": remove pyrolysis and be tired of." occupying the diet spectrum with breath ": green grass or young crops is then washed heat, and making eye bright clears away heart-fire.The ripe liver nourishing of then nourishing blood, the kidney invigorating of profit spleen." Quanzhou book on Chinese herbal medicine ": cure mainly the dysphoria with smothery sensation taking fluids profusely of quenching one's thirst, wind heat acute conjunctivitis, heatstroke dysentery.Modern pharmacology research, Fructus Momordicae charantiae has the blood sugar lowering effect: after rabbit normal and the trouble alloxan diabetes gavages the Fructus Momordicae charantiae juice, blood glucose is obviously reduced.The rat that subcutaneous injection anterior pituitary extractum causes hyperglycemia, the water extract that gavages the Fructus Momordicae charantiae juice also has the effect of blood sugar lowering.But give the oral Charantin blood sugar lowering of rabbit, model of action is similar to tolbutamide and stronger, to extracing the not complete obiteration of cat blood sugar lowering effect of pancreas, so its blood sugar lowering comprises two kinds of effects pancreas and non-pancreas.Fructus Momordicae charantiae has the summer-heat excessive thirst; Quench one's thirst; Acute conjunctivitis pain; Dysentery; The effect of sore and toxic.
Folium Ginkgo, hardship; Sweet; Puckery; Property is put down.Modern scientific research is analyzed: nimbecetin; luteolin; myricetin; Quercetin; isorhamnetin; the Flos Caryophylli flavin, nimbecetin-3-Fructus rhamni (Rhamnus davurica Pall.) glycoside, (6-is to coumaric acyl glucosyl group-β-1 for nimbecetin-3; the 4-rhamnoside; nimbecetin-3-O-(2-O-β-D-glucopyranosyl)-α-L-pyrans rhamnoside, Quercetin-3-O-[2-O-(6-O-p-coumaroyl) β-D-glucopyranosyl]-α-L-rhamnopyranosyl-7-O-β-D-glucopyanoside; Flos Caryophylli flavin-3-rutinoside; amentoflavone, ginkegetin, ginkegetin.Contain bitterness ter penoids ginkgolide A, B, C, J, M and ginkalide A again.Also contain 17 seed amino acids, in threonine is arranged, valine, methionine, leucine, isoleucine, the compositions such as aminoacid of phenylalanine and 7 kinds of needed by human of lysine; Modern pharmacological research is found, Folium Ginkgo extract goes down to old carbohydrate tolerance, and insulin and blood glucose metabolism have influence in (IGT) blood, below be improvement effect and the Study on Mechanism of Folium Ginkgo extract to insulin resistant, method: use Folium Ginkgo extract---Ginaton intravenous drip 28 days, every day 1 time, the treatment front and back are detected the blood glucose and the insulin level of cholesterolemia (TC), triacylglycerol (TG), very low density lipoprotein (VLDL) (VLDL) and 75g glucose tolerance test (OGTT) each point respectively.The result: 68 examples are after treatment, 60min, blood glucose and all obviously decline of insulin level of 120min each point after the meal after the meal on an empty stomach,, significant difference (P＜0.05), TG and VLDL be obviously decline (P＜0.05) also, stepwise regression analysis showed, TG and VLDL are obviously relevant with the blood glucose and the insulin level of OGTT each point.Conclusion: Folium Ginkgo extract can pass through blood lipid regulation level (especially TG, VLDL level), improves blood glucose metabolism and the hyperinsulinemia of old IGT.It by blood fat reducing level (especially free fatty) one of approach that improves old IGT.
Folium Mori, bitter in the mouth; Sweet; Cold in nature.Modern pharmacological research finds that Folium Mori have the rat diabetes that the hypoglycemic activity Folium Mori cause alloxan at the decortication sterone; Or the mice hyperglycemia that epinephrine, glucagon, AIS cause all has hypoglycemic activity.The decortication sterone promotes that glucose changes glycogen into, but does not change intact animal's blood sugar level.Someone thinks that contained some aminoacid can stimulate secretion of insulin with blood sugar lowering in the Folium Mori.
The Radix Astragali cures mainly the cardiopalmus of breathing hard; Asthenia; Weak; Spontaneous perspiration; Night sweat; Chronic diarrhea; Proctoptosis; Uterine prolapse; Body is impractical swollen; Chronic nephritis; Carbuncle is difficult bursts; Or burst and do not hold back for a long time." Xinhua's book on Chinese herbal medicine outline " ancient on the books: root: sweet in the mouth, slightly warm in nature.The function that invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, granulation promoting are arranged.Be used to the cardiopalmus of breathing hard, weak, collapse, spontaneous sweating, impractical swollen, the chronic nephritis of body, chronic diarrhea, proctoptosis, uterine prolapse, carbuncle be difficult bursts, open sore part disunion.QI invigorating should be processed usefulness; Hidroschesis, diuresis, expelling pus and toxin by strengthening QI, granulation promoting should be given birth to usefulness.Modern pharmacology studies show that astragalus polysaccharides has the effect of two-ways regulation blood glucose, can make that the blood sugar level of mice significantly descends behind the glucose load, and the mouse blood sugar level that can obviously cause antiadrenergic drug raises, and insulin hypoglycemia is not had obvious influence.
In sum, through lot of experiments, by meticulous screening combination, the most described hypoglycemic product is combined by above-mentioned various components in certain proportion, this kind product can effectively reduce blood glucose: at first be to generate by reducing monosaccharide, suppress glycogen and decompose, the conversion in blood sugar control source, steadily blood sugar lowering, glucose in urine.Also can stop the saccharide hydrolysis in the food, generate thereby reduce the monosaccharide that enters blood by the activity of reversible inhibition alpha-glucosidase; Next repairing islet cells, activate islet function---rebuild blood sugar regulating mechanism, remove the puzzlement of taking medicine for a long time.
Operational analysis of the present invention: above-mentioned blood sugar lowering through the test, user 380 people, wherein 375 people's effects are obvious, obvious effective rate is up to 98.7%.
The user effect analysis:
(1) example 1: the woman, and 48 years old, high 2 years of lumbago, weak companion's blood glucose were surplus, look into fasting glucose 7.6mmol/l, and the electrocardio diagram: myocardial ischemia is diagnosed as " type 2 diabetes mellitus " " coronary heart disease "; Take above-mentioned one week of hypoglycemic product, blood glucose is reduced to normally, continues to take symptom and obviously alleviates, and takes half a year blood glucose and is not raising.
(2) example 2: the man, 60 years old, suffer from type 2 diabetes mellitus, blood biochemistry: serum creatinine: 71umol/l blood urea nitrogen: 4.6mmol/l, take above-mentioned hypoglycemic product after 30 days, health greatly takes a turn for the better, and patient's fasting glucose is also normal.The state of an illness is controlled substantially.
(3) example 3: the woman, and 60 years old, suffer from diabetic nephropathy, type ii diabetes, look into fasting glucose 7.8mmol/l, 2 hours after the meal blood glucose 14.2mmol/l took above-mentioned hypoglycemic product after one month, and it is normal that patient's fasting glucose is recovered.After continuing to take, the state of an illness is controlled substantially.
(4) example 4: the man, 52 years old, find that blood glucose is high 5 years, unusual 1 year of urine examination.Fasting glucose is up to 12mol/L, is diagnosed as " type ii diabetes ", urine protein 2+, and ERY+, kidney ECT shows: glomerule GER reduces, the medium infringement of glomerule function.Took above-mentioned hypoglycemic product 16 days, sb.'s illness took a favorable turn for the patient, and urine protein is reduced to+-, ERY-, the near 6.0mol/L of fasting glucose, the foam in the urine reduces, and urine is limpid.The doctor thinks that conditions of patients is stable, can leave hospital after treatment, continues to take this product, and glycemic control is normal.
(5) example 5: the man, and 64 years old, suffer from diabetes, patient's symptom mainly shows as polydipsia, polyphagia, polyuria.Check that 2 hours after the meal blood glucose is 31.5mmol/L, glucose in urine 4+.Took above-mentioned hypoglycemic product one month, and checked that patient's blood glucose was 5.5mmol/L, symptom is obviously improved.
(6) example 6: the woman, 59 years old, the patient did not have obvious inducement polydipsia, polyphagia, polyuria before 10 years.Through local hospital diagnosis is " insulin-dependent diabetes ", and must lean on the insulin injection every day, just can blood sugar control.Albumen during the discovery of having a medical check-up before 1 year is urinated+, continue not fall, hospital diagnosis is a diabetes secondary nephritis.Found creatinine before half a year, blood urea nitrogen obviously increases.The patient engenders face and edema of lower limbs over nearly one month, and special susceptible is weak, skin pruritus, the tending to vomit of feeling sick, abdominal distention, anorexia and with diseases such as blood sugar increasing.Took above-mentioned hypoglycemic product one month, and checked that patient's blood sugar recovery was normal, other symptoms are obviously improved, and continue medication treatment at present.
Technique effect of the present invention: 1, above-mentioned hypoglycemic product adopts natural plants such as Folium Mori, Folium Ginkgo to combine fully, can effectively reduce blood glucose: generate by reducing monosaccharide, suppress glycogen and decompose, the conversion in blood sugar control source, steadily blood sugar lowering, glucose in urine; 2, by the activity of reversible inhibition alpha-glucosidase, stop the saccharide hydrolysis in the food, generate thereby reduce the monosaccharide that enters blood; 3, repairing islet cells, activate islet function---rebuild blood sugar regulating mechanism; 4, its preparation method is simple, and stable process conditions is fit to large-scale industrial production.
(4) specific embodiment:
Embodiment 1: a kind of hypoglycemic product, comprise Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 62, Folium Ginkgo 5, Folium Mori 25, the Radix Astragali 9.
The preparation method of above-mentioned a kind of hypoglycemic product may further comprise the steps:
(1) gets Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali according to the above ratio respectively, remove foreign material, clean, dry;
(2), cross 120 mesh sieves with Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and Radix Astragali pulverize separately;
(3) powder mixes with above-mentioned pulverizing is even, is product.
Embodiment 2: a kind of hypoglycemic product, comprise Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 60, Folium Ginkgo 1, Folium Mori 28, the Radix Astragali 13.
The preparation method of above-mentioned a kind of hypoglycemic product may further comprise the steps:
(1) gets Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali according to the above ratio respectively, remove foreign material, clean, dry;
(2), cross 80 mesh sieves with Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and Radix Astragali pulverize separately;
(3) powder mixes with above-mentioned pulverizing is even, incapsulates to be prepared into capsule formulation, is product.
The preparation method of above-mentioned a kind of hypoglycemic product is made medicine, capsule 200mg/ grain described in the step (3), 6 of adult usual amounts every days.
Embodiment 3: a kind of hypoglycemic product, comprise Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 65, Folium Ginkgo 3, Folium Mori 22 and the Radix Astragali 10.
The preparation method of above-mentioned a kind of hypoglycemic product may further comprise the steps:
(1) gets Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali according to the above ratio respectively, remove foreign material, clean, dry;
(2), cross 100 mesh sieves with Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and Radix Astragali pulverize separately;
(3) powder mixes with above-mentioned pulverizing is even, is pressed into Tabules, is product.
The preparation method of above-mentioned a kind of hypoglycemic product is made health food, tablet 150mg/ sheet described in the step (3), 4 of adult usual amounts every days.
Claims (7)
1. a hypoglycemic product is characterized in that comprising Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 60～65, Folium Ginkgo 1～5, Folium Mori 23～28, the Radix Astragali 9～13.
2. a kind of hypoglycemic product according to claim 1 is characterized in that comprising Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 62, Folium Ginkgo 5, Folium Mori 25, the Radix Astragali 9.
3. a kind of hypoglycemic product according to claim 1 is characterized in that comprising Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 60, Folium Ginkgo 1, Folium Mori 28, the Radix Astragali 13.
4. a kind of hypoglycemic product according to claim 1 is characterized in that comprising Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali, and its weight quota is than being Fructus Momordicae charantiae powder 65, Folium Ginkgo 3, Folium Mori 22 and the Radix Astragali 10.
5. according to the preparation method of the described a kind of hypoglycemic product of claim 1～4, it is characterized in that may further comprise the steps:
(1) gets Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and the Radix Astragali according to the above ratio respectively, remove foreign material, clean, dry;
(2), cross 80 to 120 mesh sieves with Fructus Momordicae charantiae powder, Folium Mori, Folium Ginkgo and Radix Astragali pulverize separately;
(3) powder mixes with above-mentioned pulverizing is even, is product.
6. the preparation method of a kind of hypoglycemic product according to claim 5 is characterized in that the product in the above-mentioned steps (3) is made capsule, tablet, pill, drop pill, electuary, syrup or decoction pieces dosage form.
7. according to the preparation method of claim 5 or 6 described a kind of hypoglycemic products, it is characterized in that making medicine or health food.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810154551A CN101757114A (en) | 2008-12-25 | 2008-12-25 | Hypoglycemic product and preparation method thereof |
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| CN200810154551A CN101757114A (en) | 2008-12-25 | 2008-12-25 | Hypoglycemic product and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614404A (en) * | 2012-04-10 | 2012-08-01 | 湖州中草医药开发应用研究所 | Health product with auxiliary effect on reducing blood glucose and preparation method thereof |
| CN108014160A (en) * | 2016-11-02 | 2018-05-11 | 李基镐 | The mixed-powder and its capsule and manufacture method of campanulaceae and balsam pear |
-
2008
- 2008-12-25 CN CN200810154551A patent/CN101757114A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614404A (en) * | 2012-04-10 | 2012-08-01 | 湖州中草医药开发应用研究所 | Health product with auxiliary effect on reducing blood glucose and preparation method thereof |
| CN102614404B (en) * | 2012-04-10 | 2014-11-05 | 湖州中草医药开发应用研究所 | Health product with auxiliary effect on reducing blood glucose and preparation method thereof |
| CN108014160A (en) * | 2016-11-02 | 2018-05-11 | 李基镐 | The mixed-powder and its capsule and manufacture method of campanulaceae and balsam pear |
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Open date: 20100630 |