CN101744875A - Lamiophlomis rotata traditional chinese medicine and preparation method thereof - Google Patents
Lamiophlomis rotata traditional chinese medicine and preparation method thereof Download PDFInfo
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- CN101744875A CN101744875A CN201010103094A CN201010103094A CN101744875A CN 101744875 A CN101744875 A CN 101744875A CN 201010103094 A CN201010103094 A CN 201010103094A CN 201010103094 A CN201010103094 A CN 201010103094A CN 101744875 A CN101744875 A CN 101744875A
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Abstract
The invention relates to a lamiophlomis rotata externally-applied preparation which adopts raw materials comprising a lamiophlomis rotata thick paste and an externally-applied substrate, wherein the externally-applied substrate comprises a framework material and auxiliary materials, and the framework material is a high molecular material, such as natural rubber, or mixed rubber comprising natural rubber and styrene-butadiene rubber, or a thermoplastic high molecular material; the preparation method of the lamiophlomis rotata externally-applied preparation comprises the following steps: firstly, extracting, purifying and concentrating the crude drug of lamiophlomis rotata to prepare the lamiophlomis rotata thick paste and then adding other raw materials to prepare a lamiophlomis rotata rubber ointment, wherein, macroporous resin is used for carrying out purifying. In the raw materials, menthol, wintergreen oil, borneol, camphor and the lamiophlomis rotata are matched and used according to the specific proportion of the invention, which changes the microstructure of the skin, increases the percutaneous speed and the percutaneous quantity of the medicine, improves the blood circulation and enhances the release degree of the active components of the medicine in the ointment; the effective components of the lamiophlomis rotata thick paste prepared by refluxing and extracting through adopting an ethanol solution have high proportion and high purity, so that the lamiophlomis rotata externally-applied preparation has high medicine effect and also has good stability.
Description
Technical field
The present invention relates to Radix Lamiophlomidis Rotatae Chinese medicine medicine, relate in particular to Radix Lamiophlomidis Rotatae external preparation and preparation method.
Background technology
Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo is a labiate, is used as medicine with root and root stock.Major function is a blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, be used for traumatic injury, fracture, lumbar strain, rheumatic arthralgia, bones and muscles pain etc., is the medicine of main active with the Radix Lamiophlomidis Rotatae owing to have analgesia, antiinflammatory, has the effect of invigorating blood circulation simultaneously and be widely used in treating traumatic wounds such as fracture, traumatic injury, sprain etc. and rheumatism such as rheumatic arthralgia, bones and muscles pain and rheumatism.
In recent years, very active at the research of Radix Lamiophlomidis Rotatae medicine, be that Radix Lamiophlomidis Rotatae is used as oral formulations in a large number.But need be when using as oral formulations through the first pass effect of liver owing to it, onset is slow, can not reach certain blood drug level within a short period of time, and bioavailability is low, dosage is big, directly influence the quality and the curative effect of medicine, and have certain toxic and side effects.
Summary of the invention
The object of the present invention is to provide a kind of rapid-action, bioavailability is high, good effect, toxic and side effects is low and Radix Lamiophlomidis Rotatae external preparation with antiinflammatory, pain relieving and blood circulation promoting and blood stasis dispelling function.
Another object of the present invention provides the preparation method of this Radix Lamiophlomidis Rotatae external preparation.
The present invention seeks to realize like this:
Radix Lamiophlomidis Rotatae external preparation of the present invention is to adopt to comprise that the Radix Lamiophlomidis Rotatae thick paste of effective dose and external-use substrate are the Radix Lamiophlomidis Rotatae external preparation that raw material makes, and wherein external-use substrate comprises the framework material and the adjuvant of effective dose, and described framework material is the macromolecular material of effective dose.
Above-mentioned macromolecular material is a natural rubber, or is the mixed rubber that natural rubber and butadiene-styrene rubber are formed, or is thermoplastic macromolecule material.
Above-mentioned thermoplastic macromolecule material be styrene analog thermoplastic rubber (as thermoplastic elastomer SBS, thermoplastic elastomer SIS) or/and polyolefins thermoplastic rubber or/and the polyurethanes thermoplastic macromolecule material.
The weight part ratio of butadiene-styrene rubber and natural rubber is 1: 4～10 in the above-mentioned mixed rubber.
Above-mentioned adjuvant is mainly filler, viscosifier and softening agent, wherein filler be zinc oxide or/and calcium carbonate or/and lithopone; Viscosifier are that Colophonium is or/and Petropols; Softening agent be liquid paraffin or/and lanoline or/and vaseline or/and naphthenic oil.
Above-mentioned external-use substrate be preferably 20～30 parts of natural rubbers in weight portion, zinc oxide or/and calcium carbonate or/and 15～40 parts in lithopone, Colophonium or/and 20～35 parts of Petropols, lanoline or/and liquid paraffin or/and 2～30 parts in vaseline; Or above-mentioned mixed rubber 15～35, zinc oxide or/and calcium carbonate or/and lithopone 15～40, Colophonium or/and Petropols 20～35, lanoline or/and liquid paraffin or/and vaseline 2～30; Or thermoplastic macromolecule material 15～65, zinc oxide or/and calcium carbonate or/and lithopone 15～40, Colophonium or/and Petropols 20～45, naphthenic oil 40～100.
Above-mentioned external-use substrate is in 15 parts in 15 parts of 30 parts of 30 parts in 25 parts of natural rubbers, lithopone, Petropols, the lanolines of weight portion and vaseline; 15 parts in 24 parts of natural rubbers, 6 parts in butadiene-styrene rubber, 35 parts of calcium carbonate, 20 parts of Colophonium, 3 parts of liquid paraffin and vaseline; 20 parts of 40 parts of thermoplastic elastomer SIS, thermoplastic elastomer SBS, 35 parts in lithopone, 28 parts of Colophonium, 10 parts of Petropols, 60 parts of naphthenic oils.
Above-mentioned Radix Lamiophlomidis Rotatae thick paste extract weight part is 1～5, and the external-use substrate weight portion is 1～10.
In order to reduce skin barrier, promote drug transdermal to absorb, the crude drug raw material of above-mentioned Radix Lamiophlomidis Rotatae external preparation also comprise effective dose Mentholum or/and wintergreen oil or/and Borneolum Syntheticum or/and Camphora.
Above-mentioned Radix Lamiophlomidis Rotatae thick paste is to make by the Radix Lamiophlomidis Rotatae crude drug, and the weight portion ratio relation of other crude drug raw materials of described Radix Lamiophlomidis Rotatae crude drug and above-mentioned Radix Lamiophlomidis Rotatae external preparation is: Radix Lamiophlomidis Rotatae 5～95, Mentholum 2～25, wintergreen oil 2～35, Borneolum Syntheticum 2～30, Camphora 2～35.
Preferred weight part proportioning of above-mentioned each crude drug is: Radix Lamiophlomidis Rotatae 45～95, Mentholum 5～25, wintergreen oil 5～25, Borneolum Syntheticum 5～25, Camphora 10～35.
Optimum weight part proportioning of above-mentioned each crude drug is: Radix Lamiophlomidis Rotatae 80, Mentholum 5, wintergreen oil 4, Borneolum Syntheticum 5, Camphora 10.
Utilize above-mentioned crude drug raw material can make and comprise Radix Lamiophlomidis Rotatae black plaster, tincture, gel, ointment and emplastrum Radix Lamiophlomidis Rotatae exterior-applied formulations such as (as rubber-emplastrums) by the corresponding conventional step.
Utilize above-mentioned each raw material components to make the preparation method of Radix Lamiophlomidis Rotatae external preparation of the present invention, be to utilize the Radix Lamiophlomidis Rotatae crude drug earlier through comprising extraction, purification, the concentrated Radix Lamiophlomidis Rotatae thick paste that makes, add above-mentioned other raw materials again and make the Radix Lamiophlomidis Rotatae rubber-emplastrum, described purification is to adopt macroporous resin to carry out purification.
Said extracted adopts reflux, extract,, and used reflux solvent is that the concentration expressed in percentage by volume of effective dose is 30～95% alcoholic solution.
In order to obtain the high Radix Lamiophlomidis Rotatae thick paste of purity, above-mentioned reflux, extract, number of times is three times; Extraction time is: 20～130 minutes for the first time, second and third time was respectively 20～100 minutes.
The amount that adds alcoholic solution in the above-mentioned reflux, extract, process is that be 2～10 times of Radix Lamiophlomidis Rotatae crude drug weight the first time, and second and third time is respectively 2～9 times of Radix Lamiophlomidis Rotatae crude drug weight.
Above-mentioned concentrating at twice concentrates, and is to carry out before purification step concentrating for the first time, and purification step carries out later on concentrating the second time again.
In the above-mentioned first time concentration process, the thickening temperature of extracting solution is 50 ℃～60 ℃, extracting solution is concentrated into 1～5 times of crude drug amount; For the second time in the concentration process, the relative density that the Radix Lamiophlomidis Rotatae concentrated solution of separation and purification is concentrated into Radix Lamiophlomidis Rotatae thick paste extract is 1.3～1.35; The described preferably concentrating under reduced pressure that concentrates all.
Above-mentioned Radix Lamiophlomidis Rotatae thick paste can adopt to comprise conventional solvent method with after external-use substrate mixes, and solvent-free spread-coating method or thermosol method finally make the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Specifically, prepare the preparation method of Radix Lamiophlomidis Rotatae medicine external preparation of the present invention by above-mentioned each raw material components, its step comprises:
(1), Radix Lamiophlomidis Rotatae is cleaned, chopping, add concentration expressed in percentage by volume and be 30～95% alcoholic solution reflux, extract, three times, 20～130 minutes for the first time, second and third time each 20～100 minutes, add for the first time the alcoholic solution amount and be 2～10 times of crude drug gross weight, it is 2～9 times of crude drug gross weight that second and third time adds the alcoholic solution amount;
(2), each time backflow left standstill 16 hours, the leaching supernatant, merge each time filtrate temperature is controlled at 50 ℃～60 ℃, when being evaporated to 1～5 times of crude drug amount, use the macroporous resin separation and purification, collect active ingredient, becoming relative density at 50 ℃～60 ℃ following concentrating under reduced pressure again is 1.3～1.35 Radix Lamiophlomidis Rotatae thick paste extract;
(3), with 1～5 part of the Radix Lamiophlomidis Rotatae thick paste extract of method for preparing, the Mentholum, wintergreen oil, Borneolum Syntheticum and the Camphora that add described ratio, adding 1～10 part of described external preparation substrate again mixes, adopt solvent method behind the mixing, solvent-free spread-coating method or thermosol legal system get the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Beneficial effect:
1, the reflux course in the preparation method of the present invention adopts the direct reflux, extract, of alcoholic solution, there is not water-solubility impurity in the Radix Lamiophlomidis Rotatae thick paste extract that makes, effective ingredient ratio height, purity height, thus make Radix Lamiophlomidis Rotatae external preparation drug effect height of the present invention, its good stability of while.
2, Mentholum, wintergreen oil, Borneolum Syntheticum and the Camphora in Radix Lamiophlomidis Rotatae external preparation raw material of the present invention plays the transdermal enhancer effect, itself and Radix Lamiophlomidis Rotatae are used according to special ratios of the present invention can change the skin microstructure, increase drug transdermal speed and transdermal amount, strengthened blood circulation simultaneously, improved the release of active constituents of medicine in emplastrum, reached higher blood drug level and play better therapeutical effect.
3, the Radix Lamiophlomidis Rotatae rubber-emplastrum good effect, good stability, the toxic and side effects that make of the present invention is low.
Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention is tested the Mice Auricle caused by dimethylbenzene xylene is scorching:
Get 50 of mices, the preceding 24h of administration cuts off mouse back and becomes mildewed, and with 8% sodium sulfide solution its depilation is handled then, depilation area 2.5cm * 2.5cm, to lose hair or feathers next day and the unabroken mice of skin is divided into 4 groups at random by the body weight sex, 10 every group, male female half and half.Percutaneous drug delivery, 1 successive administration of administration every day 5 days, 1h after the last administration, each treated animal is applied to mouse right ear auricle two sides with dimethylbenzene 0.05ml and causes inflammation, causes scorching back 40min and takes off neck execution mice.Lay ears same area auricle with the card punch of diameter 8mm, weigh respectively.Calculate swelling degree and suppression ratio, the results are shown in Table 1.
The scorching ear of swelling degree=cause is picked up the ears, and to cause the scorching ear sheet of picking up the ears heavy for sheet weight-non-
Swelling degree suppression ratio=(blank group swelling degree-administration group swelling degree)/blank group swelling degree * 100%
Table 1, the scorching result of the test of Mice Auricle caused by dimethylbenzene xylene
Group swelling degree (mg) inhibitory rate of intumesce P
Blank substrate matched group 28.22 ± 1.40---
Indomethacin matched group 11.15 ± 3.91 60.49%
Be subjected to reagent 1 group 9.71 ± 1.67 65.59%＜0.05
Be subjected to reagent 2 group 10.77 ± 6.62 61.84%
Be subjected to reagent 3 group 9.78 ± 1.84 65.34%
Annotate: each medication group compares with blank group, the t check.
Experimental result shows, compares with blank substrate matched group, and the administration group can significantly suppress mice two swelling due to the dimethylbenzene, and its suppression ratio is respectively: 65.59%, 61.48%, 65.34%.
The hot-plate analgesic test:
The mice of selected basis pain threshold values within 5～30 seconds is divided into 4 groups at random, and 10 every group, regulate water bath with thermostatic control to 55 ± 0.5 ℃, mice is placed on the hot plate of preheating, the fixed basis pain threshold values of resurveying again is as pain threshold values before the administration.The 1st group of every Mus two metapedes are smeared the blank substrate 0.02g of test sample, the 2nd group of every Mus two metapedes are smeared indomethacin liniment 0.02ml, 3rd, 4 groups of every Mus two metapedes are smeared test sample 0.02g, each is organized in administration and measures the pain threshold values respectively once after 10 minutes and 30 minutes, and with administration before basis pain threshold values relatively, the results are shown in Table 2.
Table 2, Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention are to the analgesic activity of mice
Pain threshold values after the administration of pain threshold values before the group administration
(s) 30min after the 10min administration after the administration
Blank substrate matched group 19.9 ± 4.4 20.9 ± 3.4 19.7 ± 7.7
Indomethacin matched group 19.8 ± 3.9 18.4 ± 7.2 18.7 ± 7.7
Be subjected to reagent 1 group 19.7 ± 6.7 28.9 ± 3.4 30.6 ± 5.3
Be subjected to reagent 2 group 18.9 ± 6.6 31.5 ± 1.4 31.7 ± 2.6
Annotate: each medication group compares with blank group, p＜0.05, t check.
Experimental result shows, compares with blank substrate matched group, and the administration group causes pain to thermostimulation significant analgesia role.Influence to the little blood vessel of Mice Auricle:
Get 25 of mices, 24h handles its auricle depilation with 8% sodium sulfide solution before the administration.To lose hair or feathers and the unabroken mice of skin is divided into 5 groups at random by the body weight sex 5 every group next day.Get the injection pentobarbital sodium, with water for injection dilution is 1% concentration, to mouse peritoneal injection (0.5mg/10g body weight), after the anesthesia mouse web portion is fixed on the little glass plate down, auricle is leveled up with microscope slide, and makes the mice environment temperature about 36 ~ 38 ℃ with big electric filament lamp.The 1st group of auricle is coated with blank substrate; The 2nd group of auricle is coated with indomethacin liniment 0.02ml; 3rd, 4 groups of auricles are coated with test sample 0.02g; The 5th group of auricle made blank.10min after the administration wipes medicine gently with cotton swab, drips a little liquid paraffin, puts microscopically at once, and the diameter with 6 * 10 times of mirrors, micrometer observed and recorded auricle artery and vein blood vessel the results are shown in Table 3.
Table 3 Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention is to the influence of the little blood vessel of Mice Auricle
Group artery diameter (um) vein diameter (um)
Substrate matched group 10 ± 0.4 16 ± 2.1
Indomethacin matched group 10 ± 0.6 17 ± 1.7
Be subjected to reagent 1 group 15 ± 1.7 24 ± 2.3
Be subjected to reagent 2 group 15 ± 1.6 24 ± 2.6
Blank group 10 ± 0.4 16 ± 0.8
Annotate: each medication group compares with blank group, p＜0.05, t check.
Experimental result shows, compares with blank substrate matched group, and the administration group improves significantly to the blood circulation of local blood capillary.
Safety:
A, acute toxicity test: adopting improvement Guan Shi method to calculate the oral LD50 of Radix Lamiophlomidis Rotatae is 97.5g/kg.New southwestern rabbit skin was smeared the Radix Lamiophlomidis Rotatae extract powder and is not occurred any unusual in crude drug 120g/kg.d result through continuous 3 months.Show that its percutaneous dosing is fool proof.
B, anaphylaxis, local irritation test: the Radix Lamiophlomidis Rotatae rubber-emplastrum is to the intact skin multiple dosing of rabbit, administration local skin epidermal area, and the skin corium organizational structure is normal.So the said preparation multiple dosing is to the intact skin nonirritant.There is not tangible sensitization yet.See the following form 1, table 2
Table 1:(Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention) skin irritation reaction grade form (n=4)
Table 2:(Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention) skin allergy degree (n=10)
Annotate: in 24h, 48h, 72h gradation are observed, the routine number scale of the highest observed allergy is gone in the table.
Stability:
Subordinate list 3
Conclusion: Radix Lamiophlomidis Rotatae rubber-emplastrum of the present invention adopts room temperature to keep sample under normal terms of packing respectively to keep sample with acceleration and carried out study on the stability 12 months, and its character, discriminating, content, adhesion strength, heat resistant test etc. all do not have significant change.
The specific embodiment:
Embodiment 1:
Raw material:
Radix Lamiophlomidis Rotatae medical material 800g Mentholum 20g Borneolum Syntheticum 30g
Camphora 20g wintergreen oil 20g azone 3g
Citral 2g natural rubber 400g zinc oxide 520g
Colophonium 400g lanoline 44g vaseline 50g
Make 1000 altogether
Preparation method:
1, gets the Radix Lamiophlomidis Rotatae pulverizing medicinal materials and become coarse powder, add 80% ethanol 8000ml reflux, extract, 3 times, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, when being concentrated into 2 times of crude drug amount, separate with macroporous resin, collect active ingredient, being evaporated to relative density 1.3～1.35 (60 ℃) again, to make Radix Lamiophlomidis Rotatae thick paste extract standby.
2, natural rubber is soaked swelling with solvent naphtha, add zinc oxide, Colophonium, lanoline and vaseline etc. successively and stir.
3, the Radix Lamiophlomidis Rotatae thick paste extract of step 1 gained and Mentholum, Borneolum Syntheticum, wintergreen oil, Camphora, azone, citral are added in the step 2 gained substrate mix, be coated with and open up on non-woven fabrics or blended cloth, cover mould release membrance or separate paper simultaneously, shear, packing promptly gets the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Embodiment 2:
Raw material:
Radix Lamiophlomidis Rotatae medical material 800g Mentholum 20g Borneolum Syntheticum 45g
Camphora 20g wintergreen oil 50g azone 3g
Citral 3g natural rubber 340g butadiene-styrene rubber 85g
Petropols 420g lithopone 480g lanoline 56g
Vaseline 30g
Make 1000 altogether
Preparation method one (solvent method):
1, gets the Radix Lamiophlomidis Rotatae pulverizing medicinal materials and become coarse powder, add 90% ethanol, 9000ml reflux, extract, 3 times, 2.0 hours for the first time, second and third time 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, when being concentrated into 2 times of crude drug amount, separate with macroporous resin, collect active ingredient, standby when being evaporated to relative density 1.3～1.35 (55 ℃) again.
2, the mixed rubber with natural rubber and butadiene-styrene rubber composition soaks swelling with solvent naphtha, adds lithopone, Petropols, lanoline and vaseline etc. successively and stirs.
3, the Radix Lamiophlomidis Rotatae thick paste extract of step 1 gained and Mentholum, Borneolum Syntheticum, wintergreen oil, Camphora, azone, citral are added in the step 2 gained substrate mix, be coated with and open up on non-woven fabrics or blended cloth, flocking cloth, cover mould release membrance or separate paper simultaneously, shear, packing promptly gets the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Preparation method two (solventless method):
1, gets the Radix Lamiophlomidis Rotatae pulverizing medicinal materials and become coarse powder, add 75% ethanol, 7500ml reflux, extract, 3 times, each 1.6 hours, merge extractive liquid,, filter, filtrate recycling ethanol when being concentrated into 1～5 times of crude drug amount, separates with macroporous resin, collect active ingredient, standby when being evaporated to relative density 1.3～1.35 (58 ℃) again.
2, employing opening rubber mixing machines such as the extract of step 1 gained and Mentholum, Borneolum Syntheticum, wintergreen oil, Camphora, azone, citral and natural rubber, butadiene-styrene rubber, lithopone, Petropols, lanoline, vaseline or banbury are made mix homogeneously.
3, with step 2 gained material, heating makes to be coated with after softening and opens up on non-woven fabrics or blended cloth, flocking cloth, covers mould release membrance or separate paper simultaneously, shears, and packing promptly gets the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Embodiment 3:
Prescription:
Radix Lamiophlomidis Rotatae medical material 800g Mentholum 20g Borneolum Syntheticum 50g
Camphora 20g wintergreen oil 40g azone 3g
Citral 3g SIS 400g SBS 50g
Petropols 425g calcium carbonate 387g alkane oil 400g
Make 1000 altogether
Preparation method:
1, gets the Radix Lamiophlomidis Rotatae pulverizing medicinal materials and become coarse powder, add 85% ethanol, 6000ml reflux, extract, 3 times, each 1.5 hours, merge extractive liquid,, filter, filtrate recycling ethanol when being concentrated into 1～5 times of crude drug amount, separates with macroporous resin, collect active ingredient, standby when being evaporated to relative density 1.3～1.35 (50 ℃) again.
2, SIS, SBS and naphthenic oil Hybrid Heating are made fusing and stirring and evenly mixing, add Petropols successively, that calcium carbonate continues heated and stirred is even.
3, the extract of step 1 gained and Mentholum, Borneolum Syntheticum, wintergreen oil, Camphora, azone, citral are added in the step 2 gained substrate mix, be sprayed at after the filtration on non-woven fabrics or blended cloth, the flocking cloth, cover mould release membrance, separate paper, Ge Laxin paper or Concha Arcae film etc. simultaneously, shear, packing promptly gets the Radix Lamiophlomidis Rotatae rubber-emplastrum.
Embodiment 4:
Radix Lamiophlomidis Rotatae medical material 800g Mentholum 20g Borneolum Syntheticum 15g
Camphora 20g wintergreen oil 45g edible oil 1000g
Plumbum preparatium 1200g azone 10g citral 8g
Make 1000 altogether
Preparation method:
1, it is standby Mentholum, Borneolum Syntheticum, Camphora and wintergreen oil to be ground into powder.
2, get the Radix Lamiophlomidis Rotatae pulverizing medicinal materials and become coarse powder, fried withered with edible oil with putting in the pot, remove slag, filter, refining is to dripping into pearl.Other gets in the Plumbum preparatium adding oil, stirs evenly receipts cream, and cream is soaked in the water.
3, get cream and melt with slow fire, the powder of adding step 1 and azone, citral stir, and share on cloth, promptly get the Radix Lamiophlomidis Rotatae black plaster.
Embodiment 5～10: undertaken by following raw material and technological parameter, other is all identical with embodiment 1, makes 1000 of Radix Lamiophlomidis Rotatae rubber-emplastrums.
| Macromolecular material | Filler | Viscosifier | Softening agent | Radix Lamiophlomidis Rotatae crude drug amount | Other crude drugs |
| Natural rubber 400g | Calcium carbonate 150 g, zinc oxide 150 g | Colophonium 400 g | Lanoline 42 g, vaseline 33g | 800g | Mentholum 50g, wintergreen oil 40 g, Borneolum Syntheticum 50g, Camphora 100g |
| Natural rubber 280g, butadiene-styrene rubber 70g | Calcium carbonate 400g | Petropols 350g | Vaseline 83 g | 800g | Mentholum 20g, wintergreen oil 20 g, Borneolum Syntheticum 20g, Camphora 20g, azone 2g |
| Natural rubber 600g | Zinc oxide 70g, lithopone 230g | Colophonium 400 g | Lanoline 62 g, liquid paraffin 30g | 800g | Mentholum 90g, wintergreen oil 80 g, Borneolum Syntheticum 20g, Camphora 20g, citral 3g |
| Polyolefins thermoplastic rubber 300g, polyurethanes thermoplastic elastomer 200g | Lithopone 350g | Colophonium 100 g, Petropols 300 g | Naphthenic oil 450 g | 800g | Mentholum 42g, wintergreen oil 35 g, Borneolum Syntheticum 30g, Camphora 35g, azone 2g, citral 2g |
| Thermoplastic elastomer SIS 220g, thermoplastic elastomer SBS 80g | Zinc oxide 280g | Petropols 320g | Naphthenic oil 420 g | 800g | Mentholum 25g, wintergreen oil 35 g, Borneolum Syntheticum 30g, Camphora 35g |
| Natural rubber 250g | Lithopone 300g | Petropols 300g | Lanoline 150 g, vaseline 150g | 800g | Mentholum 50g, wintergreen oil 40 g, Borneolum Syntheticum 50g, Camphora 100g |
| Natural rubber 240g, butadiene-styrene rubber 60g | Calcium carbonate 350g | Colophonium 200 g | Liquid paraffin 30g, vaseline 150g | 800g | Mentholum 50g, wintergreen oil 40 g, Borneolum Syntheticum 50g, Camphora 100g |
| Thermoplastic elastomer SBS 200g, thermoplastic elastomer SIS 400g | Lithopone 350g | Colophonium 280 g, Petropols 100 g | Naphthenic oil 600 g | 800g | Mentholum 50g, wintergreen oil 40 g, Borneolum Syntheticum 50g, Camphora 100g |
| Natural rubber 220g, butadiene-styrene rubber 22g | Zinc oxide 80g, calcium carbonate 160 g, lithopone 100 g | Petropols 350g | Vaseline 62 g, liquid paraffin 35g | 800g | Mentholum 13.5g, wintergreen oil 18.5g, Borneolum Syntheticum 16g, Camphora 18.5g, azone 2g |
Claims (11)
1. Radix Lamiophlomidis Rotatae external preparation, it is characterized in that: it adopts and comprises that effective dose Radix Lamiophlomidis Rotatae thick paste is that raw material and external-use substrate make the Radix Lamiophlomidis Rotatae external preparation, described external-use substrate is made up of the framework material and the adjuvant of effective dose, and framework material is the effective dose macromolecular material.
2. Radix Lamiophlomidis Rotatae external preparation as claimed in claim 1 is characterized in that: described macromolecular material is a natural rubber, or is the mixed rubber that natural rubber and butadiene-styrene rubber are formed, or is thermoplastic macromolecule material.
3. Radix Lamiophlomidis Rotatae external preparation as claimed in claim 2 is characterized in that: the weight part ratio of butadiene-styrene rubber and natural rubber is 1: 4～10 in the described mixed rubber.
4. as claim 1,2 or 3 described Radix Lamiophlomidis Rotatae external preparation, it is characterized in that: described adjuvant is mainly filler, viscosifier and softening agent, wherein filler be zinc oxide or/and calcium carbonate or/and lithopone; Viscosifier are that Colophonium is or/and Petropols; Softening agent be lanoline or/and vaseline or/and liquid paraffin or/and naphthenic oil.
5. Radix Lamiophlomidis Rotatae external preparation as claimed in claim 4 is characterized in that: described external-use substrate is natural rubber 20～30, filler 15～40, viscosifier 20～35, softening agent 2～30 in weight portion; Or natural rubber and butadiene-styrene rubber 15～35, filler 15～40, viscosifier 20～35, softening agent 2～30; Or thermoplastic macromolecule material 15～65, filler 15～40, viscosifier 20～45, softening agent 40～100.
6. as claim 1 or 5 described Radix Lamiophlomidis Rotatae external preparation, it is characterized in that: described Radix Lamiophlomidis Rotatae thick paste weight portion is 1～5, and the external-use substrate weight portion is 1～10.
7. as each described Radix Lamiophlomidis Rotatae external preparation of claim 1～6, it is characterized in that: the raw material of described Radix Lamiophlomidis Rotatae external preparation also comprise effective dose Mentholum or/and wintergreen oil or/and Borneolum Syntheticum or/and Camphora.
8. Radix Lamiophlomidis Rotatae external preparation as claimed in claim 7, it is characterized in that: described Radix Lamiophlomidis Rotatae thick paste is to make by the Radix Lamiophlomidis Rotatae crude drug, and the weight portion ratio relation of other crude drug raw materials of described Radix Lamiophlomidis Rotatae crude drug and described Radix Lamiophlomidis Rotatae external preparation is: Radix Lamiophlomidis Rotatae 5～95, Mentholum 2～25, wintergreen oil 2～35, Borneolum Syntheticum 2～30, Camphora 2～35.
9. Radix Lamiophlomidis Rotatae external preparation as claimed in claim 8 is characterized in that: the weight portion proportioning of described each crude drug is: Radix Lamiophlomidis Rotatae 80, Mentholum 5, wintergreen oil 4, Borneolum Syntheticum 5, Camphora 10.
10. as the preparation method of each described Radix Lamiophlomidis Rotatae external preparation of claim 1～9, it is characterized in that: be to utilize the Radix Lamiophlomidis Rotatae crude drug earlier through comprising extraction, purification, the concentrated Radix Lamiophlomidis Rotatae thick paste that makes, add described other raw materials again and make the Radix Lamiophlomidis Rotatae rubber-emplastrum, described purification is to adopt macroporous resin to carry out purification.
11. the preparation method of Radix Lamiophlomidis Rotatae external preparation as claimed in claim 10 is to make the Radix Lamiophlomidis Rotatae rubber-emplastrum according to the following steps by described each raw material components:
(1), the Radix Lamiophlomidis Rotatae crude drug is cleaned, shredded, add concentration expressed in percentage by volume and be 30～95% alcoholic solution reflux, extract, three times, 20～130 minutes for the first time, second and third time each 20～100 minutes, add for the first time the alcoholic solution amount and be 2～10 times of crude drug gross weight, it is 2～9 times of crude drug gross weight that second and third time adds the alcoholic solution amount;
(2), described each time reflux extracting liquid was left standstill 16 hours, the leaching supernatant, merge each time filtrate temperature is controlled at 50 ℃～60 ℃, it is evaporated to 1～5 times of crude drug amount, the separation and purification of reuse macroporous resin, collect active ingredient, becoming relative density at 50 ℃～60 ℃ following concentrating under reduced pressure is 1.3～1.35 Radix Lamiophlomidis Rotatae thick paste extract;
(3), with 1～5 part of the described Radix Lamiophlomidis Rotatae thick paste extract that makes, the Mentholum, wintergreen oil, Borneolum Syntheticum and the Camphora that add described ratio, add 1～10 part of described external preparation substrate again and mix, adopt solvent method behind the mixing, solvent-free spread-coating method or thermosol legal system get the Radix Lamiophlomidis Rotatae rubber-emplastrum.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040933A (en) * | 2012-12-28 | 2013-04-17 | 青岛爱维互动信息技术有限公司 | Medicine for treatment of rheumatic disease |
| CN103083395A (en) * | 2012-12-31 | 2013-05-08 | 安徽海神寿***业有限公司 | Preparation method of lamiophlomis rotate dry extract |
-
2010
- 2010-02-01 CN CN201010103094A patent/CN101744875A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040933A (en) * | 2012-12-28 | 2013-04-17 | 青岛爱维互动信息技术有限公司 | Medicine for treatment of rheumatic disease |
| CN103083395A (en) * | 2012-12-31 | 2013-05-08 | 安徽海神寿***业有限公司 | Preparation method of lamiophlomis rotate dry extract |
| CN103083395B (en) * | 2012-12-31 | 2015-03-25 | 安徽海神寿***业有限公司 | Preparation method of lamiophlomis rotate dry extract |
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Application publication date: 20100623 |