CN101715913B - Capsule for regulating blood fat and production process thereof - Google Patents
Capsule for regulating blood fat and production process thereof Download PDFInfo
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- CN101715913B CN101715913B CN2009102241035A CN200910224103A CN101715913B CN 101715913 B CN101715913 B CN 101715913B CN 2009102241035 A CN2009102241035 A CN 2009102241035A CN 200910224103 A CN200910224103 A CN 200910224103A CN 101715913 B CN101715913 B CN 101715913B
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Abstract
The invention relates to a capsule for regulating blood lipids. The formula consists of the following components in percentage by weight: 12 to 16 percent of grapestone extract, 40 to 85 percent of oligosaccharide, 0 to 24 percent of soybean peptide, 0 to 24 percent of phospholipid and 0.1 to 1 percent of vitamin C or vitamin A or combination of the two. The production process comprises the steps: (1) sieving the grapestone extract and the oligosaccharide for later use; (2) fully mixing the grapestone extract, the oligosaccharide, the soybean peptide, the phospholipid and the vitamin, and sieving the mixed materials; (3) filling the sieved materials by using a fully-automatic capsule filling machine; and (4) performing filling through an automatic granule counting bottling production line to prepare a finished product. The capsule has the advantages that the formula is abundant in the functional components such as resveratrol, proanthocyanidins and the like; each functional component in the formula has the effect of reducing blood fat, and has good health-care effects in the aspects of cardiovascular health care, immunity regulation, aging resistance and the like; and the capsule has a simple production process, and is suitable for industrialized production.
Description
(1) technical field
The present invention relates to a kind of health food and production process thereof of regulating blood fat, especially a kind of capsule and production process thereof of regulating blood fat.
(2) background technology
Data according to the modern medicine diseases monitoring show, more than nearly 3600 people of cardiovascular and cerebrovascular disease death toll that whole world every day causes because of hyperlipemia, the heart stalk that China causes because of high fat of blood every year, cerebral infarction, apoplexy, hemiplegia, disable, the number that causes death is with the speed rising of average annual growth 12%.Adult's blood fat of China 1/3 is generally higher at present; nearly 3,500,000 people of patient that cause apoplexy every year; more severely fearful be; in the unusual patient of China's high fat of blood, have and reach 80% patient hyperlipemia is not understood to grave danger that people's health causes; find that in investigation 50% heart stalk patient does not obtain prevention; 80% is asymptomatic quiet person in most cardiacs, and 86% cardiac just has the hazards of blood fat, dysarteriotony to exist at the morbidity previous decade.In fact hyperlipemia has now become the first stealthy killer who engulfs human health.Because of not enough to its understanding, and do not carry out active and effective prophylactic treatment, it is very serious that the result arrives PD, until the consequence that can not save.
Hyperlipemia causes " blood is thick " easily, deposits at blood vessel, forms little " patch " (being exactly " atherosclerotic " that we often say), and these " patch " artery-cloggings interrupt blood.If this situation occurs in heart, will cause coronary heart disease; Occur in brain, headstroke will occur; If occur in lower limb, will cause limb necrosis.
High fat of blood also can cause the various diseases such as hypertension, diabetes, sex dysfunction, senile dementia, pancreatitis, cirrhosis.Scientist's latest find: high fat of blood also can bring out cancer.
In the U.S., Australia, high fat of blood causes cardio-cerebrovascular disease and dead number, holds pride of place in all diseases.In China, medical circle is verified, and the probability that the high fat of blood person suffers from a heart complaint is 4 times of normal person, and closely related atherosis in artery relates generally to sustainer, coronary artery, cerebral artery and the arteria renalis.It is calm in cell and under the inner membrance due to the space between cells that atherosis formation is mainly cholesterol ester and glyceric acid fat etc., the inner membrance connective tissue proliferation, the middle level lipid infiltrates smooth muscle fibers and elastorrhexis and mucoprotein and gathers, endarterium forms ulcer, hemorrhage or local formation thrombus, calcinosis, its tube chamber narrows down gradually and causes the organ generation ischemic change of arranging, and atherogenesis and calcareous metabolic disorder cause Hyperlipemia.Relevant with reasons such as heredity, gene defect, habits and customs and other diseases.
Therefore developing a kind of health-care food of regulating blood fat just becomes particularly important.
(3) summary of the invention
The object of the present invention is to provide a kind of capsule and production process thereof of regulating blood fat, it is for solving the problems of the technologies described above, be a kind of for the hyperlipemia crowd in order to regulate the health-care food of blood fat.
Technical scheme of the present invention: a kind of capsule of regulating blood fat, it is characterized in that its prescription is to be made of grape seed extract, compound sugar, soya-bean polypeptides, phosphatide and vitamin, its percentage by weight is grape seed extract 12～16%, compound sugar 40～85%, soya-bean polypeptides 0～24%, phosphatidase 10～24%, vitamin 0.1～1%.
Vitamin is vitamin C or vitamin E or the combination of the two in the capsule of above-mentioned adjusting blood fat.
A kind of manufacturing process of capsule of above-mentioned adjusting blood fat is characterized in that being made of following steps:
(1) grape seed extract, compound sugar are crossed the 40-60 mesh sieve, for subsequent use;
(2) according to the above ratio grape seed extract, compound sugar, soya-bean polypeptides, phosphatide are fully mixed with vitamin, incorporation time 30-60 minute, mixed material was crossed the 20-40 mesh sieve;
(3) use Autocapsulefillingmachine to fill, get capsule, loading amount is the 0.35g/ grain;
(4) use automatic several bottling product lines, can 60-100 grain is product.
The health care analysis of the present invention's prescription:
One, grape seed extract
Contain abundant resveratrol and OPC in the grape seed extract, they all have special physiological function, and the mankind's health is had good health-care effect.
1, resveratrol
Resveratrol is a kind of natural antioxidant, can reduce low-density lipoprotein in the blood plasma, reduces cholesterol, reduce blood viscosity, anti-platelet clotting, keeps unobstructed blood, has antiatherosclerosis and coronary heart disease, prevents and treats the effect such as hyperlipidemia.
Associated function is as follows:
1. stop the oxidation of low-density lipoprotein, have the effect of potential prevention and cure of cardiovascular disease (atherosclerotic and coronary heart disease, ischemic heart disease, hyperlipemia etc.);
2. affect lipid and arachidonic acid metabolic;
3. antithrombotic, platelet aggregation-against;
4. anti-inflammatory, anti-allergic effects.
2, OPC
OPC is a kind of bioflavonoid that special molecular structure is arranged, it is the most effective natural of free radical in the removing human body of generally acknowledging in the world at present, has very strong activity in vivo, its Green Tea Extract oxidability of evidence is 50 times of vitamin E, ascorbic 20 times, and absorb rapidly fully, can reach the highest haemoconcentration in oral 20 minutes, metabolic half life is for 7 hours.
The plurality of health care functions of OPC:
1. OPC can reduce low-density lipoprotein and cholesterol levels in the blood plasma effectively, improves VAR.
2. protect the blood circulation system of human bodies by three approach: remove the oxygen radical that exists in the blood; Help body to stop the generation of oxygen radical; Strengthen the integrality of vascular wall.
3. prevent clostridiopetidase A and elastoser to the degradation of connective tissue, thereby be conducive to keep the elasticity of skin, the effect of performance anti aging effect.
4. can strengthen the microcirculation of eyeground retinal capillary and four limbs tip capillary.
5. the health by keeping blood vessel and improve microcirculation makes each Organ and tissue obtain sufficient blood supply.
6. can strengthen immunologic function.
7. anthocyanidin can also strengthen ascorbic effect, prolongs the time that effect occurs in human body vitamin C.
Two, compound sugar
Compound sugar claims again oligosaccharides, is by the novel starch sugar of starch by the catalytic action generation of enzyme, integrates nutrition, health care, dietotherapy, is widely used in food, health products, beverage, medicine and other fields.
The health-care effect of compound sugar:
1. compound sugar belongs to water-soluble dietary fiber, can reduce the absorption of cholesterol in the meals, can improve blood lipid metabolism, reduces the content of Blood Cholesterol and triglycerides;
2. improve micro-ecological environment in the human body, the propagation that is conducive to Bifidobacterium and other beneficial bacteriums, the organic acid that produces through metabolism makes pH value reduction in the intestines, suppress the growth of the interior salmonella of intestines and spoilage organisms, regulate gastrointestinal function, suppress corrupt substance in the intestines, change the stool proterties, anti-treating constipation, and increase the synthetic of vitamin, improve immune function of human body;
3. compound sugar belongs to non-insulin and relies on, and blood sugar is raise, and is suitable for hyperglycemia population and diabetes patient;
4. because difficult by ptyalin and the hydrolysis of small intestine digestive ferment, caloric value is very low, seldom is converted into fat;
5. do not formed matrix, the military sports effect of yet not condensing, but anti-caries by caries bacteria.
Three, soya-bean polypeptides
Soya-bean polypeptides is to make through enzymolysis, separation, purifying take soybean protein as raw material, belongs to functional polypeptide.Its amino acid forms almost in full accord with soybean protein, and the balance of essential amino acid is good, and content is also very abundant, and easier being absorbed by the body.
1. through repeatedly functional trial confirmation, Soybean Peptide has the effect that reduces blood cholesterol and triglycerides;
2. soya-bean polypeptides can not only reduce fat absorption, and can promote the metabolism of fat and energy;
3. soya-bean polypeptides can reduce hypertensive patient's blood pressure;
4. soya-bean polypeptides can promote the absorption of mineral matter.
Four, phosphatide
The effect that phosphatide has emulsification, cuts grease, can promote blood circulation, improve serum lipids, remove peroxide, make Blood Cholesterol and neutral fat content, reduce fat in the holdup time of blood vessel, promote the dissipation of atherosis spot, prevent the endangium damage that is caused by cholesterol.Take lecithin high fat of blood and high cholesterol are had significant effect.
Five, vitamin
(1) vitamin C
Vitamin C is the necessary component of participating in some enzyme of vivo oxidation reduction and hydroxylation reaction directly.
1. vitamin C can promote cholesterol degradation, change bile acid into, thereby reduces serum total cholesterol level.
2. vitamin C accelerates the degraded of serum VLDL (VLDL) and triacylglycerol by increasing the activity of lipoprotein lipase, thereby reduces the serum serum triglyceride level.
3. vitamin C is a kind of important physiological antioxidant, plays a significant role in the peroxidatic reaction of lipid that antagonism is caused by free radical.Peroxidatic reaction of lipid is one of factor that inspires atherogenesis.
(2) vitamin E
1. vitamin E can affect the activity that participates in the catabolic enzyme of cholesterol, is conducive to transhipment and the drainage of cholesterol, thereby blood lipid level is played regulating action.
2. vitamin E is in vivo prior to other material generation oxidations, thereby can prevent or reduce the oxidation of vitamin C, vitamin A, brings into play in vivo function to guarantee these materials.
3. research is found, the coupling of vitamin E, C can obtain synergistic effect anti-oxidant and that regulate blood fat.
Below by the animal experiment data, further specify beneficial effect of the present invention:
With 20 of SD rats, male and female half and half, body weight 180-200 gram.The Capsules group (regulating the Capsules group of blood fat) that is divided into high fat diet group (model group), high fat diet+adjusting blood fat, 10 of every treated animals.
High fat diet group feed formula: add 2% cholesterol, 0.05% deoxycholic acid, 10% lard in the basal feed.
Regulate the Capsules group of blood fat: regulate 20 times that the capsule dose of blood fat is behaved, people's oral dose: 2.1 grams/day, by 2.1 gram/(60 kg body weight, skies) conversions, rat feeding amount is 140mg/ (200 restrain body weight, sky).
Behind the feeding 40 days, get hematometry serum total cholesterol, triglycerides, HDL.
Detected value is as follows:
Capsules group and the model group of regulating blood fat compare, and through mathematical statistics, Capsules group serum total cholesterol and the serum triglyceride of regulating blood fat descend significantly, and serum high-density LP is significantly rising then.
In sum, the present invention explores through repetition test, in the prescription collocation of each composition ratio scientific and reasonable, each nutrition complements each other.Grape seed extract is rich in resveratrol and OPC, can effectively reduce low-density lipoprotein and cholesterol levels in the blood plasma, stops the oxidation of low-density lipoprotein, improves VAR; Compound sugar mainly by reducing the absorption of cholesterol in the meals, improves blood lipid metabolism, thereby reduces the content of Blood Cholesterol and triglycerides; Soya-bean polypeptides can not only reduce fat absorption, and can promote the metabolism of fat and energy, and then reduces blood fat; The effect that phosphatide has emulsification, cuts grease can be promoted blood circulation, improves serum lipids; Vitamin C can promote cholesterol degradation, change bile acid into, thereby reduces serum total cholesterol level; Vitamin E can affect the activity that participates in the catabolic enzyme of cholesterol, is conducive to transhipment and the drainage of cholesterol, thereby blood lipid level is played regulating action.And anthocyanidin and vitamin C compatibility, anthocyanidin can strengthen ascorbic effect, prolongs the time that effect occurs in human body vitamin C; Vitamin E and vitamin C can be obtained synergistic effect anti-oxidant and that regulate blood fat.
Eating effect case of the present invention:
1, Wu * *, the man, 71 years old, retired associate professor suffered from hyperlipidemia, atherosclerotic for many years, surveyed on an empty stomach serum total cholesterol 6.39mmoL/L, triglycerides 1.79mmoL/L.Through the capsule of edible described adjusting blood fat, after one month, again detect every day 3 times, each 2, serum total cholesterol is reduced to 5.44mmoL/L, triglycerides is reduced to 1.35mmoL/L.Reduce the blood fat successful.
2, Lee * *, the woman, 61 years old, retirement was suffered from hyperlipidemia, atherosclerotic accompanied with hypertension for many years, the time symptom such as dizzy, headache is arranged, survey on an empty stomach serum total cholesterol 6.7mmoL/L, triglycerides 5.3mmoL/L.Through the capsule of edible described adjusting blood fat, after one month, again detect every day 3 times, each 2, serum total cholesterol is reduced to 5.2mmoL/L, triglycerides is reduced to 3.6mmoL/L.Dizzy, headache symptom obviously alleviates, and rear requirement continues to take.
3, Lu * *, woman, 68 years old, hyperlipidemia, atherosclerotic accompanied with hypertension, coronary arteriosclerotic cardiopathy are suffered from retirement, and paroxysmal shirtfront squeezing property pain can occur when tired or excited, continue several minutes, have a rest or take nitrate preparations after alleviate.Survey on an empty stomach serum total cholesterol 6.9mmoL/L, triglycerides 2.3mmoL/L.Through the capsule of edible described adjusting blood fat, after one month, again detect every day 3 times, each 2, serum total cholesterol is reduced to 5.7mmoL/L, triglycerides is reduced to 1.8mmoL/L.Other symptoms also have alleviation, and rear requirement continues to take.
4, open * *, the man, 42 years old, the company manager, operating pressure is large, and the family dinner party of often accompanying a guest has hypertension history.Survey on an empty stomach serum total cholesterol 6.5mmoL/L, triglycerides 4.8mmoL/L during health check-up.Through the capsule of edible described adjusting blood fat, every day 3 times, each 2, and require to keep suitably having a rest, after one month, again detecting, serum total cholesterol is reduced to 5.2mmoL/L, triglycerides is reduced to 2.4mmoL/L.Rear requirement continues to take.
Superiority of the present invention and technique effect are: 1, the capsule of above-mentioned adjusting blood fat adopts the functional raw materials such as highly purified grape seed extract, compound sugar, soya-bean polypeptides, phosphatide, vitamin, wherein be rich in the functional components such as resveratrol, OPC in the grape seed extract, each functional component all has the effect that reduces blood fat in the prescription, but the principle that reduces blood fat is different, each composition can be from different perspectives, Synergistic, promotes mutually; 2, the capsule of regulating blood fat is having preferably health-care efficacy except to regulating blood fat significant effect being arranged aspect cardiovascular health, adjusting immunity, anti-ageing the waiting for a long time;
3, manufacturing process is simple, is fit to suitability for industrialized production.
(4) specific embodiment:
Embodiment 1:
A kind of capsule of regulating blood fat comprises grape seed extract, compound sugar, vitamin C, and its percentage by weight is grape seed extract 15.5%, compound sugar 84.4%, vitamin C 0.1%.
A kind of manufacturing process of capsule of above-mentioned adjusting blood fat may further comprise the steps:
(1) grape seed extract, compound sugar are crossed 60 mesh sieves, for subsequent use;
(2) according to the above ratio grape seed extract, compound sugar are fully mixed with vitamin C, incorporation time 30 minutes, mixed material is crossed 20 mesh sieves;
(3) use Autocapsulefillingmachine to fill, be green, white glues capsule, loading amount is the 0.35g/ grain;
(4) use automatic several bottling product lines, can is the capsule of 60 every bottle adjusting blood fat.
Embodiment 2:
A kind of capsule of regulating blood fat, comprise grape seed extract, soya-bean polypeptides, phosphatide, compound sugar, vitamin C, vitamin E, its percentage by weight is grape seed extract 16%, soya-bean polypeptides 22%, phosphatidase 12 0%, compound sugar 41%, vitamin C 0.2%, vitamin E 0.8%.
A kind of manufacturing process of capsule of above-mentioned adjusting blood fat may further comprise the steps:
(1) grape seed extract, soya-bean polypeptides, compound sugar are crossed 40 mesh sieves, for subsequent use;
(2) according to the above ratio grape seed extract, soya-bean polypeptides, phosphatide, compound sugar are fully mixed with vitamin C, vitamin E, incorporation time 60 minutes, mixed material is crossed 40 mesh sieves;
(3) use Autocapsulefillingmachine to fill, be green, white glues capsule, loading amount is the 0.35g/ grain;
(4) use automatic several bottling product lines, can is the capsule of 60 every bottle adjusting blood fat.
Embodiment 3:
A kind of capsule of regulating blood fat, comprise grape seed extract, soya-bean polypeptides, compound sugar, vitamin C, vitamin E, its percentage by weight is grape seed extract 15%, soya-bean polypeptides 24%, compound sugar 60.5%, vitamin C 0.1%, vitamin E 0.4%.
A kind of manufacturing process of capsule of above-mentioned adjusting blood fat may further comprise the steps:
(1) grape seed extract, soya-bean polypeptides, compound sugar are crossed 60 mesh sieves, for subsequent use;
(2) according to the above ratio grape seed extract, soya-bean polypeptides, compound sugar, vitamin C are fully mixed with vitamin E, incorporation time 45 minutes, mixed material is crossed 20 mesh sieves;
(3) use Autocapsulefillingmachine to fill, be green, white glues capsule, loading amount is the 0.35g/ grain;
(4) use automatic several bottling product lines, can is the capsule of 60 every bottle adjusting blood fat.
Claims (5)
1. capsule of regulating blood fat, it is characterized in that its prescription is to be made of grape seed extract, compound sugar, soya-bean polypeptides, phosphatide and vitamin, its percentage by weight is grape seed extract 12～16%, compound sugar 40～85%, soya-bean polypeptides 0～24%, phosphatidase 10～24%, vitamin 0.1～1%; Wherein vitamin is vitamin C or vitamin E or the combination of the two.
2. a kind of capsule of regulating blood fat according to claim 1 is characterized in that its prescription is grape seed extract, compound sugar, vitamin C, and its percentage by weight is grape seed extract 15.5%, compound sugar 84.4%, vitamin C 0.1%.
3. a kind of capsule of regulating blood fat according to claim 1, it is characterized in that its prescription is grape seed extract, soya-bean polypeptides, phosphatide, compound sugar, vitamin C, vitamin E, its percentage by weight is grape seed extract 16%, soya-bean polypeptides 22%, phosphatidase 12 0%, compound sugar 41%, vitamin C 0.2%, vitamin E 0.8%.
4. a kind of capsule of regulating blood fat according to claim 1, it is characterized in that its prescription is grape seed extract, soya-bean polypeptides, compound sugar, vitamin C, vitamin E, its percentage by weight is grape seed extract 15%, soya-bean polypeptides 24%, compound sugar 60.5%, vitamin C 0.1%, vitamin E 0.4%.
5. the manufacturing process of the capsule of an adjusting blood fat claimed in claim 1 is characterized in that being made of following steps:
(1) grape seed extract, compound sugar are crossed the 40-60 mesh sieve, for subsequent use;
(2) in the described ratio of claim 1 grape seed extract, compound sugar, soya-bean polypeptides, phosphatide are fully mixed with vitamin, incorporation time 30-60 minute, mixed material was crossed the 20-40 mesh sieve;
(3) use Autocapsulefillingmachine to fill, get capsule, loading amount is the 0.35g/ grain;
(4) use automatic several bottling product lines, can 60-100 grain is product.
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102342415B (en) * | 2011-10-10 | 2013-06-05 | 武汉东方天琪生物工程有限公司 | Composition capable of improving gastrointestinal tract function and assisting lowering of blood sugar and blood lipid |
| WO2013053072A1 (en) * | 2011-10-10 | 2013-04-18 | Huang Daiyong | Gastrointestinal tract function improvement-based composition aiding reductions in blood sugar and in blood lipids |
| CN102919356B (en) * | 2012-11-13 | 2014-06-25 | 陕西师范大学 | Preparation method for lactic acid bacteria goat milk powder |
| CN105661499A (en) * | 2016-01-07 | 2016-06-15 | 南京贝杉国际贸易有限公司 | Functional food capable of clearing blood fat, and preventing cardiovascular and cerebrovascular diseases and preparation method |
| CN107006864B (en) * | 2017-04-17 | 2020-12-11 | 代宗延 | Polypeptide resveratrol preparation, preparation method and application thereof, and health-care product or pharmaceutical composition containing polypeptide resveratrol preparation |
| CN109700023A (en) * | 2017-10-25 | 2019-05-03 | 东莞自然衡健康科技有限公司 | A kind of functional food of anti-aging and preparation method thereof |
| CN108159431A (en) * | 2017-12-28 | 2018-06-15 | 天津百利食品有限公司 | A kind of phosphatide complexes and preparation method thereof |
| CN108208766A (en) * | 2018-01-15 | 2018-06-29 | 中鸿纳米纤维技术丹阳有限公司 | A kind of calcium tablet with nanometer pelelith powder for treating diabetes |
| CN107951027A (en) * | 2018-01-15 | 2018-04-24 | 中鸿纳米纤维技术丹阳有限公司 | A kind of pelelith composite nutrient for strengthening anti-cancer tumor suppressor function |
| CN108618134A (en) * | 2018-05-03 | 2018-10-09 | 江苏二十维生物科技有限公司 | A kind of healthy diet intervention product and its preparation method and application |
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