CN101704723B - 羟甲基取代邻烷基联苯及其中间体的制备方法 - Google Patents
羟甲基取代邻烷基联苯及其中间体的制备方法 Download PDFInfo
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- CN101704723B CN101704723B CN 200910198083 CN200910198083A CN101704723B CN 101704723 B CN101704723 B CN 101704723B CN 200910198083 CN200910198083 CN 200910198083 CN 200910198083 A CN200910198083 A CN 200910198083A CN 101704723 B CN101704723 B CN 101704723B
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- 0 *c(cccc1)c1-c1ccccc1 Chemical compound *c(cccc1)c1-c1ccccc1 0.000 description 3
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Abstract
Description
实施例 | 金属催化剂 | 用量(g) | 含量(%) | 收率(%) |
2 | 氯化铁 | 1.6 | 99.45 | 76.2 |
3 | 氧化亚铁 | 0.4 | 99.33 | 73.7 |
4 | 五水硫酸铜 | 0.6 | 99.25 | 74.8 |
5 | 二水醋酸锌 | 11 | 99.64 | 72.2 |
6 | 六水硝酸镍 | 0.15 | 99.23 | 71.3 |
7 | 四水醋酸钴 | 0.6 | 99.31 | 70.5 |
8 | 二氧化锰 | 22 | 99.42 | 72.3 |
9 | 无水硫酸镁 | 60 | 99.56 | 75.1 |
实施例 | 酸类助催化剂 | 用量(g) | 含量(%) | 收率(%) |
10 | 原甲酸三乙酯 | 40 | 99.55 | 76.4 |
11 | 三氯乙酸 | 98 | 99.73 | 72.3 |
12 | 甲磺酸 | 48 | 99.51 | 74.2 |
13 | 乙酸 | 3 | 99.42 | 71.2 |
14 | 丙烯酸 | 0.36 | 99.38 | 70.1 |
15 | 三氟乙酸 | 0.3 | 99.14 | 71.0 |
16 | 磷酸 | 2.45 | 99.23 | 73.2 |
17 | 对甲基苯磺酸 | 0.1 | 99.62 | 74.5 |
实施例 | 反应温度(℃) | 含量(%) | 收率(%) |
18 | 20 | 99.55 | 76.4 |
19 | 40 | 99.73 | 72.3 |
20 | 60 | 99.23 | 71.2 |
21 | 80 | 99.12 | 70.5 |
实施例 | 亚硝酸酯 | 用量(g) | 含量(%) | 收率(%) |
22 | 亚硝酸异丙基酯 | 111.25 | 99.75 | 74.9 |
23 | 亚硝酸甲基酯 | 91.5 | 99.64 | 74.2 |
24 | 亚硝酸乙基酯 | 75 | 99.35 | 73.8 |
25 | 亚硝酸叔丁基酯 | 77.25 | 99.24 | 72.2 |
26 | 亚硝酸正戊基酯 | 58.6 | 99.15 | 70.8 |
实施例 | 苯的用量(g) | 含量(%) | 收率(%) |
27 | 195.3 | 99.75 | 74.9 |
28 | 1952.7 | 99.34 | 77.2 |
29 | 4686.6 | 99.72 | 72.7 |
30 | 39.1 | 99.61 | 71.2 |
31 | 390.6 | 99.79 | 72.9 |
32 | 3905.5 | 99.74 | 74.5 |
33 | 5858.3 | 99.73 | 75.7 |
实施例 | 卤代邻烷基苯胺 | 得到卤代邻烷基联苯的量(g) | 含量(%) | 收率(%) |
34 | 3-氯代邻甲基苯胺 | 77.8 | 99.79 | 76.8 |
35 | 3-溴代邻乙基苯胺 | 97.4 | 99.64 | 74.6 |
36 | 3-氟代邻丙基苯胺 | 77.2 | 99.35 | 73.4 |
37 | 3-碘代邻丁基苯胺 | 121.2 | 99.22 | 72.1 |
38 | 邻戊基苯胺 | 79.6 | 99.15 | 71.0 |
Claims (10)
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CN 200910198083 CN101704723B (zh) | 2009-11-02 | 2009-11-02 | 羟甲基取代邻烷基联苯及其中间体的制备方法 |
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CN 200910198083 CN101704723B (zh) | 2009-11-02 | 2009-11-02 | 羟甲基取代邻烷基联苯及其中间体的制备方法 |
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CN101704723A CN101704723A (zh) | 2010-05-12 |
CN101704723B true CN101704723B (zh) | 2013-04-24 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101863775B (zh) * | 2010-05-25 | 2013-03-13 | 重庆大学 | 一种苯胺衍生物氧化偶联一步合成联苯二胺衍生物的方法 |
CN102964217B (zh) * | 2012-11-30 | 2014-10-01 | 江苏优嘉化学有限公司 | 一种连续的格氏和羟基化反应制备联苯醇的方法 |
CN103896792B (zh) * | 2014-04-18 | 2016-06-22 | 四川安东油气工程技术服务有限公司 | 适用于高温碳酸岩储层酸化用有机多元羧酸及转向酸及其制备方法 |
CN108658726B (zh) * | 2017-03-30 | 2022-06-10 | 石家庄圣泰化工有限公司 | 2,4-二氟联苯的合成方法 |
CN108658725B (zh) * | 2017-03-30 | 2022-06-10 | 石家庄圣泰化工有限公司 | 2-氟联苯的合成方法 |
CN109503320A (zh) * | 2018-11-28 | 2019-03-22 | 赵学迅 | 一种联苯醇的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2087886A (en) * | 1979-12-19 | 1982-06-03 | Upjohn Co | Preparing biphenyl compounds by coupling |
CN1935761A (zh) * | 2006-09-27 | 2007-03-28 | 荆和祥 | 2-甲基-3-苯基苯甲醇的制备方法 |
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2009
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2087886A (en) * | 1979-12-19 | 1982-06-03 | Upjohn Co | Preparing biphenyl compounds by coupling |
CN1935761A (zh) * | 2006-09-27 | 2007-03-28 | 荆和祥 | 2-甲基-3-苯基苯甲醇的制备方法 |
Non-Patent Citations (1)
Title |
---|
陈恒昌等.合成联苯衍生物的改良方法.《有机化学》.1989,第9卷(第1期),49-50. * |
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