CN101698094B - Distillate for treating white vein diseases and preparation method thereof - Google Patents
Distillate for treating white vein diseases and preparation method thereof Download PDFInfo
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- CN101698094B CN101698094B CN2009102112617A CN200910211261A CN101698094B CN 101698094 B CN101698094 B CN 101698094B CN 2009102112617 A CN2009102112617 A CN 2009102112617A CN 200910211261 A CN200910211261 A CN 200910211261A CN 101698094 B CN101698094 B CN 101698094B
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Abstract
The invention discloses a drug composition distillate for treating white vein diseases and a preparation method thereof. The distillate is obtained by dosage form preparation with the prescription of white vein ointments, namely the traditional Tibetan drugs as the basic prescription. The invention adopts the preparation method of extracting part of the drugs and processing the other part of the drugs in an ultramicro manner, thus not only effectively retaining the active ingredients in the drugs, but also greatly increasing the content of the crude drug components, improving the bioavailability and bettering the curative effects. The distillate of the invention has the advantages of strong and good effects, rapid and reliable curative effects, convenient use and the like. The volatile oil contained in the distillate can obviously weaken ease pain; therefore, the curative effects are obviously enhanced.
Description
Invention field
The present invention relates to a kind of distillate medicinal water and preparation method thereof, particularly a kind of distillate medicinal water for the treatment of aortic arch syndrome and preparation method thereof.
Technical background
The lung-pulse ointment is that the doctor among the people of Tibetan is carried according to " Tibetan medicine doctor certainly addendum releases difficulty ", the Four-Volume Medical Code two secretaries, in conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, the lung-pulse ointment is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:
Rhizoma Curcumae Longae 150g, Semen Myristicae 50g, Radix Et Rhizoma Nardostachyos 80g, Actinolitum 50g, Radix Glycyrrhizae 70g, artificial Moschus or Moschus 0.7g, Rhizoma Kaempferiae 100g, Fructus cari carvi 130g, Rhizoma Acori Calami 70g, Pericarpium Zanthoxyli 50g, trona 75g.
Method for making: above ten simply, and except that artificial Moschus or other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add artificial Moschus or Moschus fine powder facing-up, with butter and Adeps Sus domestica furnishing ointment, promptly.
Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.
According to Tibetan medicine's theory, disorders of meridian is divided into the lung-pulse and Hei Mai, wherein the lung-pulse is the venation that human body at first bears at embryo stage, it also is the venation that fetal development obtains nutrition, these venations of birth back play again and absorb diet elite, conveying waste matter, to guarantee the normal circulation of three factors, seven materials,, can cause the generation of various diseases if the function of these venations gets muddled.The main pathogenic factor of aortic arch syndrome has following three aspects: aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; Mechanical damages such as weapons club cause rheumatism; In disorder and go into sering.The Tibetan medicine is the vital energy regualting and blood circulation-promoting collateral dredging to the regulation principle of aortic arch syndrome.Tibetan people is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record, in conjunction with long-term practical experience, with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Moschus, Fructus cari carvi, Pericarpium Zanthoxyli, trona is the Tibetan medicine the lung-pulse ointment of raw material production, be subjected to the trust of extensive patients with significant mass effect, but traditional Tibetan medicine the lung-pulse ointment preparation technology is modulated into ointment after all crude drug fine powders are mixed, its technology is numerous and diverse, and batch production cycle is long, the production technology instability; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.
Summary of the invention
It is the distillate medicinal water that basic square tube is crossed the treatment aortic arch syndrome that dosage changing form prepares that the object of the invention is to disclose a kind of prescription with traditional Tibetan medicine the lung-pulse ointment, and the object of the invention also is to disclose the preparation method of this distillate medicinal water.
The present invention seeks to be achieved through the following technical solutions.
The crude drug of distillate medicinal water of the present invention is formed and consumption is:
Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, trona 15-20 weight portion.
The crude drug of distillate medicinal water of the present invention is formed and consumption is preferably:
Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, trona 18.2 weight portions.
The preparation method of distillate medicinal water of the present invention comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5-20 times of water of medicine gross weight, soaked 5-30 hour, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5 times of water of medicine gross weight, soaked 5 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 10 times of water of medicine gross weight, soaked 12 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 15 times of water of medicine gross weight, soaked 24 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 20 times of water of medicine gross weight, soaked 30 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 8 times of water of medicine gross weight, soaked 28 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
The preparation method of distillate medicinal water of the present invention preferably includes following steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 18 times of water of medicine gross weight, soaked 8 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
Distillate medicinal water of the present invention is compared with prior art the lung-pulse ointment has following characteristics:
1, distillate medicinal water of the present invention has advantages such as effect is strong, effective, curative effect is reliable rapidly, easy to use.
2, the distillate medicinal water made of the inventive method, its volatile oil that contains obviously weakens analgesia, and therapeutic effect obviously strengthens.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The effect experiment data of experimental example 1 distillate medicinal water of the present invention
1, reagent, animal and instrument
(1) reagent
The lung-pulse ointment (XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides) of conventional dosage forms;
The lung-pulse ointment 1 (preparation method: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of mixed powder gross weight, decoct with water 1 time, collect volatile oil simultaneously, amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is standby; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01～200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby; 4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.)；
The lung-pulse ointment 2 (preparation method: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, standby; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01～200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby; 4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.)；
The lung-pulse ointment 3 (preparation method: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, trona pick totally, is ground into the superfine powder that particle diameter is 10～40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol, 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate, add water to 100 parts, stir system cream at 75～85 ℃, add Moschus when waiting to be cooled to 35～40 ℃ and stir, make ointment, discharging, room temperature was placed 3～8 hours, and the adding antiseptic is an amount of, and packing promptly.)；
Distillate medicinal water of the present invention (embodiment 1 is prepared from the description according to the present invention), glacial acetic acid.
(2) instrument
The portable balance of electronics (model: YB1201, Haikang, Shanghai Electronic Instruments Plant); Stopwatch (SW8-2008); Syringe (specification: 1ml) etc.
(3) animal
Kunming mouse, body weight (20 ± 2) g, 4 monthly ages female Mus.
2, method and result
(1) method
Get 60 of Kunming mouses, be divided into 6 groups at random, 10 every group, be made as the lung-pulse ointment group (II), the lung-pulse ointment 1 group of (III), the lung-pulse ointment 2 groups of (IV), the lung-pulse ointment 3 groups of (V), distillate medicinal waters of the present invention (VI) of matched group (I), conventional dosage forms respectively.Except that matched group, other each groups purify the mouse back hair with barium sulfide before the experiment.Except that matched group, all the other are respectively organized back depilation place respectively and smear administration, the lung-pulse ointment group of 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, conventional dosage forms, smear administration, dosage is 0.4g/kg (crude drug in whole), and 0.4g/kg of the present invention is smeared at administration group back, (crude drug in whole 0.4g/kg), administration every day 1 time, successive administration 3 days.Last administration 1h pneumoretroperitoneum is only injected 0.6% acetum 0.2ml/, turns round the body number of times in the 15min behind the record injection acetic acid, calculates the suppression ratio of medicine to writhing response.Pass judgment on medicine analgesic effect: suppression ratio %=(matched group is turned round body average-reagent group and turned round the body average)/matched group is turned round body average * 100%.
(2) result
Adopt the SPSS11.5 statistical software to carry out date processing, data result shows that blank group and other each groups all have salient pole work property difference (P＜0.01).Prompting the lung-pulse ointment group (II) of conventional dosage forms and the lung-pulse ointment 1 group (III), the lung-pulse ointment 2 groups (IV), the lung-pulse ointment 3 groups (V), other each organize and all can suppress the animal that glacial acetic acid causes and turn round body.III, IV, V organize between three groups does not have significant difference, and has significant difference between the VI group.The analgesic activity of prompting the lung-pulse ointment 1 group (III), the lung-pulse ointment 2 groups (IV), the lung-pulse ointment 3 groups (V) is better than the lung-pulse ointment group (II) of conventional dosage forms, and the analgesic activity of distillate medicinal water of the present invention (VI) is better than the lung-pulse ointment group (II), the lung-pulse ointment 1 group of (III), the lung-pulse ointment 2 groups of (IV), 3 groups of the lung-pulse ointment (V) of conventional dosage forms.Result such as table 1.
The acetic acid twisting analgesic experiment result of table 1 distillate medicinal water of the present invention
(compare △ P＜0.05, △ △ P＜0.01 with the I group; Compare ★ P＜0.05, ★ ★ P＜0.01 with the VI group)
Following embodiment all can realize the described effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: distillate medicinal water of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g.
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5 times of water of medicine gross weight, soaked 5 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 2: distillate medicinal water of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 10 times of water of medicine gross weight, soaked 12 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 3: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 15 times of water of medicine gross weight, soaked 24 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 4: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 20 times of water of medicine gross weight, soaked 30 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 5: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 8 times of water of medicine gross weight, soaked 28 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 6: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 18 times of water of medicine gross weight, soaked 8 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 7: distillate medicinal water of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g.
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5 times of water of medicine gross weight, soaked 24 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 8: distillate medicinal water of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 10 times of water of medicine gross weight, soaked 30 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 9: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 15 times of water of medicine gross weight, soaked 8 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 10: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 20 times of water of medicine gross weight, soaked 5 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 11: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 8 times of water of medicine gross weight, soaked 12 hours, distillate is collected, is merged in distillation, adds the Moschus fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Embodiment 12: distillate medicinal water of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;
Preparation method:
1. the artificial Moschus is ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 18 times of water of medicine gross weight, soaked 28 hours, distillate is collected, is merged in distillation, adds artificial Moschus's fine powder, and encapsulation promptly gets distillate medicinal water of the present invention.
Claims (17)
1. distillate medicinal water for the treatment of aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, trona 15-20 weight portion; It is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5-20 times of water of medicine gross weight, soaked 5-30 hour, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
2. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5 times of water of medicine gross weight, soaked 5 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
3. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 10 times of water of medicine gross weight, soaked 12 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
4. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 15 times of water of medicine gross weight, soaked 24 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
5. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 20 times of water of medicine gross weight, soaked 30 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
6. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 8 times of water of medicine gross weight, soaked 28 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
7. distillate medicinal water as claimed in claim 1 is characterized in that this distillate medicinal water is to be prepared from by following method:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 18 times of water of medicine gross weight, soaked 8 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
8. as the arbitrary described distillate medicinal water of claim 1-7, it is characterized in that the crude drug of this distillate medicinal water consists of:
Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, trona 18.2 weight portions.
9. as the preparation method of the arbitrary described distillate medicinal water of claim 1-8, it is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5-20 times of water of medicine gross weight, soaked 5-30 hour, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
10. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 5 times of water of medicine gross weight, soaked 5 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
11. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 10 times of water of medicine gross weight, soaked 12 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
12. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 15 times of water of medicine gross weight, soaked 24 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
13. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 20 times of water of medicine gross weight, soaked 30 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
14. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 8 times of water of medicine gross weight, soaked 28 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
15. the preparation method of distillate medicinal water as claimed in claim 9 is characterized in that this method comprises the steps:
1. artificial Moschus or Moschus are ground to form fine powder;
2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;
3. take by weighing the mixing medical material that 2. above-mentioned steps obtains, with 18 times of water of medicine gross weight, soaked 8 hours, distillate is collected, is merged in distillation, adds artificial Moschus or Moschus fine powder, and encapsulation promptly.
16. have application in the medicine of analgesic activity in preparation as the arbitrary described distillate medicinal water of claim 1-7.
17. distillate medicinal water as claimed in claim 8 has application in the medicine of analgesic activity in preparation.
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| CN2009102112617A CN101698094B (en) | 2009-11-05 | 2009-11-05 | Distillate for treating white vein diseases and preparation method thereof |
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| CN2009102112617A CN101698094B (en) | 2009-11-05 | 2009-11-05 | Distillate for treating white vein diseases and preparation method thereof |
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| CN113181331A (en) * | 2021-05-27 | 2021-07-30 | 西藏奇正藏药股份有限公司 | Application of Tibetan medicine composition in preparing medicine for preventing and/or treating diabetic peripheral neuropathy |
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