CN101670059A - Health product for preventing and treating children anorexia and preparation method thereof - Google Patents
Health product for preventing and treating children anorexia and preparation method thereof Download PDFInfo
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- CN101670059A CN101670059A CN200910036004A CN200910036004A CN101670059A CN 101670059 A CN101670059 A CN 101670059A CN 200910036004 A CN200910036004 A CN 200910036004A CN 200910036004 A CN200910036004 A CN 200910036004A CN 101670059 A CN101670059 A CN 101670059A
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Abstract
The invention discloses a health product for preventing and treating children anorexia, which comprises the following components in parts by weight: 3-9 rhizoma atractylodis, 5-15 charred fructus crataegi, 1-5 endothelium corneum gigeriae galli, 3-9 stir-baked semen raphani, 3-9 melanoidin malt and 0-1 excipient. The health product for preventing and treating children anorexia mainly adopts the ideas of activating spleen-energy and reinforcing the spleen, selects the rhizoma atractylodis, charred fructus crataegi, endothelium corneum gigeriae galli, stir-baked semen raphani and melanoidin maltwhich are used as both medicine and food, and adopts the modern pharmaceutical technology to prepare the product into powder for preventing and treating children anorexia, having good taste and no toxic side effect after being taken for a long time and improving digestion, thereby preventing and treating children anorexia fundamentally. The invention contains no chemical additive or toxic side effect after being taken for a long time.
Description
Technical field
The invention belongs to health product technology field, be specifically related to a kind of health product of preventing and treating infantile anorexia and preparation method thereof.
Background technology
Infantile anorexia is meant children's's long period inappetence or loss of appetite, sees that food is not greedy, very then refusing to eat, and food-intake reduces.With anorexia, to eat without digesting, stool is not adjusted to feature, is children's's a kind of common phenomenon in period.Be common in 1～12 years old child, the city incidence rate is higher than the rural area, all can take place throughout the year, especially to see at the beginning of autumn late summer more.Anorexia is all influential to children's's growth promoter, nutriture, intelligence development.Long-term anorexia can cause infantile malnutrition, anemia, rickets and hypoimmunity, recurrent respiratory tract infection occur.
Investigation shows that the incidence rate of infantile appetite problem is about 12～14%, and China children's (below 14 years old) has more than 300,000,000, and anorexia takes place by children's about 40,000,000 more than.Someone improves in varying degrees to food configuration, and the survey result in district shows: growth in the living standard at present, be directly proportional with the climbing of infantile anorexia, and the anorexia performance is many with the city children's.Because the existing trencherman of detesting does not obtain the effective treatment and exists, new anorexia children's constantly produces again,
Chinese and western medicine is basic identical to its origin cause of formation understanding, but in treatment and conditioning, but has his own strong points, and doctor trained in Western medicine satisfies the needs of body to the shortage material with replenishing of digestive enzymes, trace element, but the considerable part effect is undesirable.The traditional Chinese medical science is improved dysfunction of spleen and stomach based on the conditioning of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs side's medicine.Aspect the improving of cardinal symptom, experimental index, motherland's medical science is all excellent than the zinc preparation that doctor trained in Western medicine is recommended.Facts have proved that utilization traditional Chinese medical herbal treatment or conditioning infantile anorexia not only can be adjusted spleen and stomach function, facilitating digestion absorbs, thereby improves the anorexia situation, and can improve the level of trace element such as body zinc.
The conventional Chinese medicine that is used for infantile anorexia conditioning or treatment at present has drugs strengthening spleen, digestants, damp-resolving medicinal, QI regulating medicine, the depressed liver-energy dispersing medicine, yin-nourishing drug, antipyretic, blood circulation promoting medicine, anthelmintic, rushes down intestinal stasis relieving medicine, apophlegmatisant, softening the hard mass medicine etc. down.Wherein drugs strengthening spleen, digestants, damp-resolving medicinal, QI regulating medicine account for 83% of medicine total amount commonly used.Many clinically based on QI invigorating activating the spleen, digesting and appetizing, regulate the flow of vital energy be amusing, removing dampness helps fortune, reach the effect of the simultaneous phenomenon of eliminating apositia by the conditioning of whole body, the main at present Drug therapy that adopts, rush down OTC medicines such as instant granule for curing, strengthening the spleen to promote digestion ball based on help digestion electuary, children of the fragrant Fructus Citri tangerinae ball of compound Taizi ginsen granule (crown prince's treasured), JIANWEI XIAOSHI PIAN, children's, compound recipe, the product of health product is less.Most of drug port perception is relatively poor, poor compliance, and child especially infant is beyond affordability, even refuses clothes.Some new varieties taste good, but contain certain hormone and chemical flavouring additive, take certain side effect for a long time.
Summary of the invention
Technical problem to be solved by this invention provide a kind of mouthfeel good, take the health product of control infantile anorexia without any side effects for a long time.
The technical problem that the present invention also will solve provides the preparation method of above-mentioned health product.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of health product of preventing and treating infantile anorexia is characterized in that it comprises the component of following parts by weight: 3～9 parts of Rhizoma Atractylodis, 5～15 parts of Fructus Crataegi (parched to brown)s, 1～5 part of Endothelium Corneum Gigeriae Galli, 3～9 parts of Semen Raphani (parched), 3～9 parts of Fructus Hordei Germinatus (parched to brown)s, 0～1 part of adjuvant.
Wherein, described adjuvant be in sucrose, aspartame, lactose, microcrystalline Cellulose and the dextrin any one or multiple.
The preparation method of the health product of above-mentioned control infantile anorexia comprises the steps:
(1) 3～9 parts of Rhizoma Atractylodis vapor distillations is extracted volatile oil, keep medicinal liquid I and medicinal residues that still-process produces simultaneously;
(2) the volatile oil β-CDBao He that step (1) is obtained gets clathrate;
(3) medicinal residues that step (1) is obtained and 5～15 parts of Fructus Crataegi (parched to brown)s, 3～9 parts of Semen Raphani (parched) and 3～9 parts of Fructus Hordei Germinatus (parched to brown)s are closed and fry in shallow oil, filter medicinal liquid II;
(4) the medicinal liquid II that obtains of medicinal liquid I that step (1) is obtained and step (3) merges, concentrate concentrated solution;
(5), get the Endothelium Corneum Gigeriae Galli micropowder with 1～5 part of Endothelium Corneum Gigeriae Galli superfine grinding;
(6) the Endothelium Corneum Gigeriae Galli micropowder suspendible that obtains of the concentrated solution that obtains of the clathrate that step (2) is obtained, step (4) and step (5) adds 0～1 part of adjuvant, mix homogeneously, and spray drying is promptly.
In the step (1), the Rhizoma Atractylodis vapor distillation extracts the volatile oil condition and is: 5～10 times of weight water, soak time are 0.5～2 hour, and distillation time 4～6 hours is collected volatile oil.
In the step (2), volatile oil with the method for β-CDBao He is: add volatile oil in the saturated aqueous solution of β-CD under stirring condition, the enclose temperature is 40～50 ℃, the enclose time is 1～2 hour, β-CD is 4～8: 1 with the weight ratio of oil, refrigerator was placed 12～24 hours then, filtered 40～60 ℃ of dryings.
In the step (3), medicinal residues and Fructus Crataegi (parched to brown), Semen Raphani (parched) and Fructus Hordei Germinatus (parched to brown) are closed the condition of frying in shallow oil and are: 8～16 times of weight water, extract each 1～3h 1～3 time.
In the step (5), the Endothelium Corneum Gigeriae Galli superfine grinding method is: adopt Universalpulverizer to be ground into 100 purpose fine powders Endothelium Corneum Gigeriae Galli earlier, be ground into 500 purpose micropowders through ZHWY-100 type jet mill again.The running parameter of jet mill is: air consumption 1～3m
3/ min pulverizes pressure 0.8～1.2Mpa, feed pressure 0.5～0.8Mpa, charging rate 2Kg/h.
In the step (6), the spray drying condition is: 150～200 ℃ of inlet temperature, 70～90 ℃ of leaving air temps.In the step (6), described adjuvant be in sucrose, aspartame, lactose, microcrystalline Cellulose and the dextrin any one or multiple.
Beneficial effect: the health product of control infantile anorexia of the present invention mainly adopt " activating the spleen, spleen reinforcing " thought, select medicinal and edible Chinese medicine material Rhizoma Atractylodis, Fructus Crataegi (parched to brown), Endothelium Corneum Gigeriae Galli, Semen Raphani (parched), Fructus Hordei Germinatus (parched to brown), reasonable formula, adopt the modern pharmaceutical technology, it is good to be made into a kind of mouthfeel, take control infantile anorexia without any side effects, the powder of facilitating digestion for a long time, be used to nurse one's health or treat deficiency on the infantile anorexia product to overcome present stage.We one are confrontational based on consumer product dredge stasis, and strengthening the spleen and stomach is the therapeutic scheme of assisting, and can reach effects a permanent cure is main, and not only effected a permanent cure but also controlled the intended purposes of table, be a kind of enhancement digestion, all-ages health food.
Description of drawings
Accompanying drawing is preparation technology's flow chart of the present invention.
The specific embodiment
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand that the described concrete material proportion of embodiment, process conditions and result thereof only are used to illustrate the present invention, and should also can not limit the present invention described in detail in claims.
Embodiment 1:
Get Rhizoma Atractylodis 6kg, place extraction pot, add water 40000mL, soaked 1 hour earlier, redistillation 5 hours gets 25g volatile oil; Get 25g volatile oil, splash in 45 ℃ of 150g β-CD saturated aqueous solutions, 100r/min stirred 1 hour, was positioned over refrigerator, and static spending the night filtered, and 60 ℃ of dryings 5 hours are crossed 80 mesh sieves, promptly get the 160g clathrate.
Get Endothelium Corneum Gigeriae Galli 3kg, adopt Universalpulverizer to be ground into 100 purpose fine powders, be ground into 500 purpose micropowders through ZHWY-100 type jet mill again.The running parameter of jet mill is: air consumption 1～3m
3/ min pulverizes pressure 0.8～1.2Mpa, feed pressure 0.5～0.8Mpa, charging rate 2Kg/h.
Get the medicinal residues and surplus medicine Fructus Crataegi (parched to brown) 10kg, the Semen Raphani (parched) 6kg that obtain after the Rhizoma Atractylodis distillation, Fructus Hordei Germinatus (parched to brown) 6kg fries in shallow oil altogether, and amount of water 300000mL extracts 2 times, and each 2h filters, and filtrate and Rhizoma Atractylodis distillate are merged, and is concentrated into 30000mL.
Get above-mentioned clathrate, the Endothelium Corneum Gigeriae Galli fine powder is suspended in the concentrated medicament, adds 0.2kg sucrose, makes dissolving, and spray drying is selected 150～200 ℃ of inlet temperature, 70～90 ℃ of leaving air temps for use.Get fine powder 7kg, packing, quality inspection promptly gets thing of the present invention.(3g/ bag).
Embodiment 2:
Identical with the method for embodiment 1, different is that Rhizoma Atractylodis are got 3kg, and Fructus Crataegi (parched to brown) is got 5kg, and Endothelium Corneum Gigeriae Galli is got 1kg, and Semen Raphani (parched) is got 3kg, and Fructus Hordei Germinatus (parched to brown) is got 3kg, and adjuvant is dextrin 0.2kg.
Embodiment 3:
Identical with the method for embodiment 1, different is that Rhizoma Atractylodis are got 9kg, and Fructus Crataegi (parched to brown) is got 15kg, and Endothelium Corneum Gigeriae Galli is got 5kg, and Semen Raphani (parched) is got 9kg, and Fructus Hordei Germinatus (parched to brown) is got 9kg, does not add adjuvant.
Embodiment 4:
Get product that embodiment 1 makes by Ministry of Public Health " health food check and assessment technique standard version in 2003 " experiment.(1) to the influence of rat body weight, weight gain, food ration.
Get 40 of SD rats, heroes are divided into 4 groups at random by body weight, and 10 every group, normal saline group: give isopyknic distilled water; Small dose group: 0.07g/kg; Middle dosage group: 0.13g/kg; Heavy dose of group: 0.25g/kg; The continuous gastric infusion of each dosage group 30 days, administration volume 10ml/kg.Calculate body weight, weight gain, food ration during off-test.The results are shown in Table 1.
The influence of table 1 pair rat body weight, weight gain, food ration (X ± s) (n=10)
Compare with negative control group:
*P＜0.05
The result shows: in, heavy dose of group can significantly improve food ration and negative control group have significant difference (
*P＜0.05) point out this medicine that the function of improving digestive function is arranged.
(2) intestinal motility test.
Get 50 of Kunming mouses, heroes are divided into 5 groups at random by body weight, 10 every group: negative control group gives the equal-volume distilled water; Model group: give the equal-volume distilled water; Small dose group: 0.13g/kg; Middle dosage group: 0.25g/kg; Heavy dose of: 0.5g/kg continued medication 30 days.Model group is with the modeling of compound recipe diphenoxylate, with prepared Chinese ink as indicator.Fasting be can't help water 16 hours before the off-test, 30min gives compound diphenoxylate 10mg/kg after the last administration except that the blank group, give 15% burnt black ink behind the 30min, put to death animal after 25 minutes, taking-up is whole section small intestinal to caecum portion from pylorus, does not add traction and tile and calculate the intestinal propulsion rate to line measurement small intestinal total length with by pylorus to ink motion forward position displacement.The results are shown in Table 2.
Influence (X ± s) (n=10) of table 2 pair mouse small intestine propelling rate
Compare with negative control group:
▲P＜0.05; Compare with model group:
*P＜0.05
The result shows: the prepared Chinese ink advance distance of model group and intestinal propulsion rate reduce and negative control group is compared, and there were significant differences (P＜0.05), the modeling success.And middle heavy dose of group can significantly improve prepared Chinese ink advance distance and intestinal propulsion rate and model group significant difference (P＜0.05) is relatively arranged.
Claims (10)
1, a kind of health product of preventing and treating infantile anorexia is characterized in that it comprises the component of following parts by weight: 3～9 parts of Rhizoma Atractylodis, 5～15 parts of Fructus Crataegi (parched to brown)s, 1～5 part of Endothelium Corneum Gigeriae Galli, 3～9 parts of Semen Raphani (parched), 3～9 parts of Fructus Hordei Germinatus (parched to brown)s, 0～1 part of adjuvant.
2, the health product of control infantile anorexia according to claim 1, the described adjuvant of its feature be in sucrose, aspartame, lactose, microcrystalline Cellulose and the dextrin any one or multiple.
3, the preparation method of the health product of the described control infantile anorexia of claim 1 is characterized in that it comprises the steps:
(1) 3～9 parts of Rhizoma Atractylodis vapor distillations is extracted volatile oil, keep medicinal liquid I and medicinal residues that still-process produces simultaneously;
(2) the volatile oil β-CDBao He that step (1) is obtained gets clathrate;
(3) medicinal residues that step (1) is obtained and 5～15 parts of Fructus Crataegi (parched to brown)s, 3～9 parts of Semen Raphani (parched) and 3～9 parts of Fructus Hordei Germinatus (parched to brown)s are closed and fry in shallow oil, filter medicinal liquid II;
(4) the medicinal liquid II that obtains of medicinal liquid I that step (1) is obtained and step (3) merges, concentrate concentrated solution;
(5), get the Endothelium Corneum Gigeriae Galli micropowder with 1～5 part of Endothelium Corneum Gigeriae Galli superfine grinding;
(6) the Endothelium Corneum Gigeriae Galli micropowder suspendible that obtains of the concentrated solution that obtains of the clathrate that step (2) is obtained, step (4) and step (5) adds 0～1 part of adjuvant, mix homogeneously, and spray drying is promptly.
4, the preparation method of the health product of control infantile anorexia according to claim 3, it is characterized in that in the step (1) that the Rhizoma Atractylodis vapor distillation extracts the volatile oil condition and is: 5～10 times of weight water, soak time are 0.5～2 hour, distillation time 4～6 hours is collected volatile oil.
5, the preparation method of the health product of control infantile anorexia according to claim 3, it is characterized in that in the step (2), volatile oil with the method for β-CDBao He is: add volatile oil in the saturated aqueous solution of β-CD under stirring condition, the enclose temperature is 40～50 ℃, the enclose time is 1～2 hour, and β-CD is 4～8: 1 with the weight ratio of oil, and refrigerator was placed 12～24 hours then, filter 40～60 ℃ of dryings.
6, the preparation method of the health product of control infantile anorexia according to claim 3 is characterized in that in the step (3), medicinal residues and Fructus Crataegi (parched to brown), Semen Raphani (parched) and Fructus Hordei Germinatus (parched to brown) are closed the condition of frying in shallow oil and be: 8～16 times of weight water, extract each 1～3h 1～3 time.
7, the preparation method of the health product of control infantile anorexia according to claim 3, it is characterized in that in the step (5), the Endothelium Corneum Gigeriae Galli superfine grinding method is: adopt Universalpulverizer to be ground into 100 purpose fine powders Endothelium Corneum Gigeriae Galli earlier, be ground into 500 purpose micropowders through ZHWY-100 type jet mill again.
8, the preparation method of the health product of control infantile anorexia according to claim 7 is characterized in that the running parameter of jet mill is: air consumption 1～3m
3/ min pulverizes pressure 0.8～1.2Mpa, feed pressure 0.5～0.8Mpa, charging rate 2Kg/h.
9, the preparation method of the health product of control infantile anorexia according to claim 3 is characterized in that the spray drying condition is in the step (6): 150～200 ℃ of inlet temperature, 70～90 ℃ of leaving air temps.
10, the preparation method of the health product of control infantile anorexia according to claim 3 is characterized in that in the step (6), described adjuvant be in sucrose, aspartame, lactose, microcrystalline Cellulose and the dextrin any one or multiple.
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| CN200910036004A CN101670059A (en) | 2009-10-15 | 2009-10-15 | Health product for preventing and treating children anorexia and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919530A (en) * | 2011-08-09 | 2013-02-13 | 郭道山 | Chinese herbal medicinal feed additive |
| CN105146533A (en) * | 2015-07-27 | 2015-12-16 | 南通昊友食品添加剂有限公司 | Food additive capable of alleviating dietary bias |
| CN106578795A (en) * | 2016-12-04 | 2017-04-26 | 山东岐伯堂生物科技有限公司 | Stomach strengthening and digestion promoting drink for children and preparation method thereof |
| CN112914057A (en) * | 2021-03-19 | 2021-06-08 | 江苏食品药品职业技术学院 | Food additive for improving food preference and preparation method and application thereof |
-
2009
- 2009-10-15 CN CN200910036004A patent/CN101670059A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919530A (en) * | 2011-08-09 | 2013-02-13 | 郭道山 | Chinese herbal medicinal feed additive |
| CN105146533A (en) * | 2015-07-27 | 2015-12-16 | 南通昊友食品添加剂有限公司 | Food additive capable of alleviating dietary bias |
| CN106578795A (en) * | 2016-12-04 | 2017-04-26 | 山东岐伯堂生物科技有限公司 | Stomach strengthening and digestion promoting drink for children and preparation method thereof |
| CN112914057A (en) * | 2021-03-19 | 2021-06-08 | 江苏食品药品职业技术学院 | Food additive for improving food preference and preparation method and application thereof |
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Open date: 20100317 |