CN101666726A - Piston pressure-regulating high-sensitivity small-tension film-shaped biomaterial mechanic detector - Google Patents
Piston pressure-regulating high-sensitivity small-tension film-shaped biomaterial mechanic detector Download PDFInfo
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- CN101666726A CN101666726A CN200910190947A CN200910190947A CN101666726A CN 101666726 A CN101666726 A CN 101666726A CN 200910190947 A CN200910190947 A CN 200910190947A CN 200910190947 A CN200910190947 A CN 200910190947A CN 101666726 A CN101666726 A CN 101666726A
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Abstract
The invention discloses a piston pressure-regulating high-sensitivity small-tension film-saped biomaterial mechanic detector which comprises a sample fixing ring (4), a sample loading platform (5), arack stand column (7), a top panel (7a), a bearing panel (7b), a movable clamping plate (8), a tensioning threaded rod (9), a dumbbell type screw nut (12), a stepper motor (19), a pressure sensor (1)and a microcomputer (22), and also comprises a locating rod (6), a transparent pressurizing loading box (3), a displacement sensor (13), a three-way valve (16), a piston pressure regulator (17) and aball screw (18). The detector has simple and reasonable structure, can accurately detect low-tension tissue engineering products such as skin, bones, veins, tendon, muscles and the like, and other soft tissue materials, is flexible and convenient in operation and control, can monitor the changing states visually when the sample is detected, can reflect the loading change flexibly and resist environmental interference, and guarantee the accuracy of detected data. The detector provides an ideal mechanic performance detecting tool for batch production and quality control of the tissue engineeringbiomaterials.
Description
Technical field
The invention belongs to strength characteristics, particularly a kind of solid material apparatus for testing mechanical that applies stable tension or pressure with mechanical pressure test solid material.
Background technology
Along with the progress and the maturation of tissue engineering technique, the development of organization engineering skin is also maked rapid progress with application.Clinical for guaranteeing that organization engineering skin is applied to better, its biophysical properties, particularly biomechanical property should obtain paying much attention to.The research mechanical property also needs indexs such as the length and width of material and thickness, and conventional equipment is to being difficult to accurate measurement than film like soft-tissue material thickness, in order to quantize the biomechanical property of the membranaceous biomaterial of small tension receiving coil such as organization engineering skin, essential develop a kind of can the detection of biological material mechanical performance and the device of thickness.
In the prior art, the CN1789958A that we have a name to be called " apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial " disclosed on June 21st, 2006, and had obtained patent right.It is assembled by pressure transducer, forbay, sample set collar, load sample platform, top panel, load-bearing panel, active clamped plate, fastening screw, bearing, dumbbell shape nut, pressure regulating box, pulley, glass tube, lifting stay cord, flexible pipe, stepper motor, data conductor, pilot and microcomputer.It can carry out conveniently, detect accurately product such as tissue engineering skin, bone, blood vessel, tendon, muscle and soft-tissue material etc., and detected value all calculates with Pa, and operation control is quick convenient.But this device is found still to come with some shortcomings in actual applications: 1) the sample set collar is in free state and is not fixed, sample can be fixed on the load sample platform and keep airtight in the less fashion of sample tension force, but sample tension force then may leak gas even the set collar slippage when big; 2) this device places sample in the opaque seal-off pressure case, and the variation in sample holder state and the test process all can't be observed, and is difficult to determine whether whether sample reached airtight requirement by correct clamping, clamping; 3) this device pressure-loaded system is by promoting the glass tube that internal diameter is more much smaller than pressure regulating box internal diameter, provide pressure by the liquid level difference between glass tube and the pressure regulating box for pressure regulating box, air can cause the glass liquid in pipe constantly to flow to pressure regulating box because of being compressed in the case, and the height that liquid level descends in the accent glass tube is the several times of liquid level rising height in the pressure regulating box, and to reach design pressure in theory as being 10KPa, then require the liquid level difference of both sides to reach the 1.33m height, therefore this pressure-loaded system effectiveness is low, operation inconvenience.
Summary of the invention
Above-mentioned defective at prior art CN1789958A existence, we intend it is improved, adopting directly, the mode of the interior air of compression closed container loads, design a kind of piston pressure-regulating formula apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial, make it simple in structure, profile is small and exquisite, easy to operate, the degree of accuracy height, good reproducibility also can detect the high-sensitivity small-tension film-shaped biomaterial mechanic performance of a plurality of indexs, can be to engineered skin, bone, blood vessel, tendon, product such as muscle and other are as mesenterium, manadesma, the mechanical property of soft-tissue materials such as cardiac valves accurately detects easily.
The technical solution used in the present invention is as follows.
A kind of piston pressure-regulating formula apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial comprises sample set collar, load sample platform, framework pillar, top panel, load-bearing panel, active clamped plate, fastening screw, bearing, dumbbell shape nut, stepper motor, pressure transducer and microcomputer; Active clamped plate and framework pillar are nested, and being provided with top above the active clamped plate is the load sample platform of circular platform type, has ring groove in load sample platform deep bid lower surface, and the convex annular that is complementary with load sample platform deep bid lower surface ring groove is arranged above the active clamped plate; The dumbbell shape nut passes the center pit of load-bearing panel and closes with the weight-bearing surface integrated circuit board, make the transmission of dumbbell shape nut energy, be provided with bearing between the lower nut head of dumbbell shape nut and the load-bearing panel, fastening screw and the screwed connection of dumbbell shape nut, fastening screw top is a pot mouthful top shape and props up active clamped plate; Pressure transducer links to each other with microcomputer with the pressure sensor data line, and stepper motor links to each other with microcomputer with pilot; It is characterized in that:
1) it also has backstay, transparent supercharging to load case, superset displacement sensor, underlying displacement transducer, communicating pipe, T-valve, piston pressure-regulating device and ball-screw;
2) backstay is vertically fixed on the top panel bottom surface or above the active clamped plate, after making active clamped plate clamped just, the length of backstay can guarantee that the sample on the load sample platform is smooth harmless, transparent supercharging loads the case bottom surface and offers the circular hole of bore less than sample set collar external diameter, the sample set collar is connected as one with the coaxial transparent supercharging loading case bottom surface that is close to of circular hole, sample set collar inwall is consistent with the round platform tapering of load sample platform also to be nested with the round platform coupling, transparent supercharging loading case end face is provided with straight pipe and is communicated with pressure transducer, transparent supercharging loading case side is provided with straight pipe and is communicated with communicating pipe, transparent supercharging loading case end face is close to the top panel bottom center and is connected as one, and the superset displacement sensor is coaxial to be arranged under the straight-through mouth of pipe of transparent supercharging loading case end face;
3) ball-screw one end is fixedlyed connected with the rotating shaft of stepper motor, the other end links to each other with the piston rod of piston pressure-regulating device, transparent supercharging loads between case and the piston pressure-regulating device with being communicated with communicating pipe, be provided with the T-valve that can be communicated with atmosphere communicating pipe, piston pressure-regulating device and stepper motor are fixed on the stand;
4) load sample platform center has the bellmouth consistent with the round platform tapering, the coaxial bellmouth end opening that is arranged on of underlying displacement transducer, and the lower nut head of dumbbell shape nut is welded with handle;
5) the superset displacement sensor links to each other with microcomputer with the displacement transducer data line respectively with the underlying displacement transducer.
Piston pressure-regulating formula high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention, its principle of work is: before detection, piston with the piston pressure-regulating device places the inflator back-end location earlier, again film sample to be detected (sample) is placed on the round platform mouth of load sample platform, rotate dumbbell shape nut handle with hand and raise fastening screw, with moving on the active clamped plate and the round platform of load sample platform be positioned to be nested into and be close in the sample set collar that transparent supercharging loads the case bottom surface, it is smooth nondestructively by evenly that sample is able between the round platform of load sample platform and sample set collar, firm clamping, so far sample is in the confined space of transparent supercharging loading case, it is logical to open the T-valve atmosphere on communicating pipe, make in the system and to press identical with atmospheric pressure identically, close atmosphere then and lead to guarantee the test starting condition; During detection, microcomputer is after pilot sends steering order to stepper motor, promote the piston of piston pressure-regulating device by stepper motor, slowly the air in the compression confined space raises pressure, realization is to the even loading of sample, and can regulate pressure-loaded speed as required, the pressure-dependent displacement data of sample central part that displacement transducer is gathered, the specimen surface institute on-load pressure data that pressure transducer is gathered, feed back to by data conductor and to carry out data processing in the microcomputer, when film breaks, stop measuring, microcomputer to sensor acquisition to pressure and change in displacement data calculate and can obtain thickness, ultimate tensile strength, strain, index such as creep and Young modulus, and in time obtain showing and storage, the simultaneity factor internal pressure is reduced to atmospheric pressure, stepper motor drives the piston of piston pressure-regulating device and gets back to initial position, original state is got back to by system, revolution dumb-bell shape nut handle makes the load sample platform reduce with active clamped plate and gets back to initial position, takes off the sample of testing and new sample can be installed carry out new test.
Piston pressure-regulating formula high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention, simple and reasonable, it has overcome the defective of prior art fully, can be to the tissue engineering skin of low-tension, bone, blood vessel, tendon, product such as muscle and other are as mesenterium, manadesma, cardiac valves soft-tissue material etc. carries out convenience, detect accurately, can measure thickness, ultimate tensile strength, strain, index such as creep and Young modulus, operation control is sensitive convenient, but sample is its situation of change of visual monitoring when detecting, can reflect the variation of load and the interference that can resist environment delicately, guarantee to detect the accurate of data.Apparatus of the present invention provide a kind of desirable mechanical property testing tool for the batch process and the quality control of engineered biomaterial.
Four, description of drawings
Accompanying drawing is the broken section structural representation of piston pressure-regulating formula high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention at clamped condition.
In the drawings, the 1-pressure transducer, the 2-sample, the transparent supercharging of 3-loads case, 4-sample set collar, 5-load sample platform, 6-backstay, 7-framework pillar, 7
a-top panel, 7
b-load-bearing panel, 8-active clamped plate, 9-fastening screw, 10-handle, 11-bearing, 12-dumbbell shape nut, 13
a-superset displacement sensor, 13
b-underlying displacement transducer, 14-displacement transducer data line, 15-communicating pipe, 16-T-valve, 17-piston pressure-regulating device, 18-ball-screw, 19-stepper motor, 20-pilot, 21-stand, 22-microcomputer, 23-pressure sensor data line.
Five, embodiment
Further specify concrete structure of apparatus of the present invention and its principle of work below in conjunction with accompanying drawing.
A kind of piston pressure-regulating formula apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial comprises sample set collar 4, load sample platform 5, framework pillar 7, top panel 7
a, load-bearing panel 7
b, active clamped plate 8, fastening screw 9, bearing 11, inferior bell type nut 12, stepper motor 19, pressure transducer 1 and microcomputer 22; Active clamped plate 8 is nested with framework pillar 7, being provided with top above the active clamped plate 8 is the load sample platform 5 of circular platform type, have ring groove in load sample platform 5 deep bid lower surfaces, the convex annular that is complementary with load sample platform 5 deep bid lower surface ring grooves is arranged above the active clamped plate 8; Dumbbell shape nut 12 passes load-bearing panel 7
bCenter pit and with load-bearing panel 7
bEngaging makes the 12 energy transmissions of dumbbell shape nut, the lower nut head of dumbbell shape nut 12 and load-bearing panel 7
bBetween be provided with bearing 11, fastening screw 9 and 12 screwed connections of dumbbell shape nut, fastening screw 9 tops are a pot mouthful top shape and prop up active clamped plate 8; Pressure transducer 1 usefulness pressure sensor data line 23 links to each other with microcomputer 22, and stepper motor 19 usefulness pilots 20 link to each other with microcomputer 22; It is characterized in that:
1) it also has backstay 6, transparent supercharging to load case 3, superset displacement sensor 13
a, underlying displacement transducer 13
b, communicating pipe 15, T-valve 16, piston pressure-regulating device 17 and ball-screw 18;
2) backstay 6 is vertically fixed on top panel 7
aBottom surface or above the active clamped plate 8, after making active clamped plate 8 clamped just, the length of backstay 6 can guarantee that the sample 2 on the load sample platform 5 is smooth harmless, transparent supercharging loads case 3 bottom surfaces and offers the circular hole of bore less than sample set collar 4 external diameters, sample set collar 4 is connected as one with coaxial transparent supercharging loading case 3 bottom surfaces that are close to of circular hole, sample set collar 4 inwalls are consistent with the round platform tapering of load sample platform 5 also to be nested with the round platform coupling, transparent supercharging loading case 3 end faces are provided with straight pipe and are communicated with pressure transducer 1, transparent supercharging loading case 3 sides are provided with straight pipe and are communicated with communicating pipe 15, and transparent supercharging loads case 3 end faces and is close to top panel 7
aBottom center is connected as one, superset displacement sensor 13
aCoaxial being arranged under the straight-through mouth of pipe of transparent supercharging loading case 3 end faces;
3) ball-screw 18 1 ends are fixedlyed connected with the rotating shaft of stepper motor 19, the other end links to each other with the piston rod of piston pressure-regulating device 17, transparent supercharging loads between case 3 and the piston pressure-regulating device 17 with being communicated with communicating pipe 15, be provided with the T-valve 16 that can be communicated with atmosphere communicating pipe 15, piston pressure-regulating device 17 and stepper motor 19 are fixed on the stand 21;
4) load sample platform 5 centers have the bellmouth consistent with the round platform tapering, underlying displacement transducer 13
bThe coaxial bellmouth end opening that is arranged on, the lower nut head of dumbbell shape nut 12 is welded with handle 10;
5) the superset displacement sensor 13
aWith underlying displacement transducer 13
bLink to each other with microcomputer 22 with displacement transducer data line 14 respectively.
Piston pressure-regulating formula high-sensitivity small-tension film-shaped biomaterial mechanic device for detecting performance of the present invention, its principle of work is: before detection, piston with piston pressure-regulating device 17 places the inflator back-end location earlier, again film sample to be detected (sample) is placed on the round platform mouth of load sample platform 5, rotate dumbbell shape nut handle 10 with hand and raise fastening screw 9, with moving on the active clamped plate 8 and the round platform of load sample platform 5 be positioned to be nested into and be close in the sample set collar 4 that transparent supercharging loads case 3 bottom surfaces, it is smooth nondestructively by evenly that sample 2 is able between the round platform of load sample platform 5 and sample set collar 4, firm clamping, so far sample 2 is in the confined space of transparent supercharging loading case 3, it is logical to open T-valve 16 atmosphere on communicating pipe 15, make in the system and to press identical with atmospheric pressure identically, close atmosphere then and lead to guarantee the test starting condition; During detection, microcomputer 22 is after 20 pairs of stepper motors 19 of pilot send steering order, promote the piston of piston pressure-regulating device 17 by stepper motor 19, slowly the air in the compression confined space raises pressure, realization is to the even loading of sample 2, and can regulate pressure-loaded speed as required, superset displacement sensor 13
aWith underlying displacement transducer 13
bThe pressure-dependent displacement data of gathering of sample 2 central parts, the sample 2 surperficial institute on-load pressure data that pressure transducer 1 is gathered, feed back to by data conductor and to carry out data processing in the microcomputer 22, when film breaks, stop measuring, 22 pairs of sensor acquisition of microcomputer to pressure and change in displacement data calculate and can obtain thickness, ultimate tensile strength, strain, index such as creep and Young modulus, and in time obtain showing and storage, the simultaneity factor internal pressure is reduced to atmospheric pressure, the piston that stepper motor 19 drives piston pressure-regulating device 17 is got back to initial position, original state is got back to by system, revolution dumb-bell shape nut handle 10 makes load sample platform 5 reduce with active clamped plate 8 and gets back to initial position, takes off the sample of testing and new sample can be installed carry out new test.
Claims (1)
1, a kind of piston pressure-regulating formula apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial comprises sample set collar (4), load sample platform (5), framework pillar (7), top panel (7
a), load-bearing panel (7b), active clamped plate (8), fastening screw (9), bearing (11), dumbbell shape nut (12), stepper motor (19), pressure transducer (1) and microcomputer (22); Active clamped plate (8) is nested with framework pillar (7), being provided with top above the active clamped plate (8) is the load sample platform (5) of circular platform type, have ring groove in load sample platform (5) deep bid lower surface, the convex annular that is complementary with load sample platform (5) deep bid lower surface ring groove is arranged above the active clamped plate (8); Dumbbell shape nut (12) passes load-bearing panel (7
b) center pit and with load-bearing panel (7
b) engaging, make the transmission of dumbbell shape nut (12) energy, the lower nut head of dumbbell shape nut (12) and load-bearing panel (7
b) between be provided with bearing (11), fastening screw (9) and dumbbell shape nut (12) screwed connection, fastening screw (9) top is a pot mouthful top shape and props up active clamped plate (8); Pressure transducer (1) links to each other with microcomputer (22) with pressure sensor data line (23), and stepper motor (19) links to each other with microcomputer (22) with pilot (20); It is characterized in that:
1) it also has backstay (6), transparent supercharging to load case (3), superset displacement sensor (13
a), underlying displacement transducer (13
b), communicating pipe (15), T-valve (16), piston pressure-regulating device (17) and ball-screw (18);
2) backstay (6) is vertically fixed on top panel (7
a) bottom surface or above the active clamped plate (8), after making active clamped plate (8) clamped just, the length of backstay (6) can guarantee that the sample (2) on the load sample platform (5) is smooth harmless, transparent supercharging loads case (3) bottom surface and offers the circular hole of bore less than sample set collar (4) external diameter, sample set collar (4) is connected as one with coaxial transparent supercharging loading case (3) bottom surface that is close to of circular hole, sample set collar (4) inwall is consistent with the round platform tapering of load sample platform (5) also to be nested with the round platform coupling, transparent supercharging loading case (3) end face is provided with straight pipe and is communicated with pressure transducer (1), transparent supercharging loading case (3) side is provided with straight pipe and is communicated with communicating pipe (15), and transparent supercharging loads case (3) end face and is close to top panel (7
a) bottom center is connected as one superset displacement sensor (13
a) coaxial being arranged under the straight-through mouth of pipe of transparent supercharging loading case (3) end face;
3) ball-screw (18) one ends are fixedlyed connected with the rotating shaft of stepper motor (19), the other end links to each other with the piston rod of piston pressure-regulating device (17), transparent supercharging loads between case (3) and the piston pressure-regulating device (17) with being communicated with communicating pipe (15), be provided with the T-valve (16) that can be communicated with atmosphere communicating pipe (15), piston pressure-regulating device (17) and stepper motor (19) are fixed on the stand (21);
4) load sample platform (5) center has the bellmouth consistent with the round platform tapering, underlying displacement transducer (14
b) the coaxial bellmouth end opening that is arranged on, the lower nut head of dumbbell shape nut (12) is welded with handle (10);
5) the superset displacement sensor (13
a) and underlying displacement transducer (13
b) use displacement transducer data line (14) to link to each other with microcomputer (22) respectively.
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| CN2009101909472A CN101666726B (en) | 2009-09-24 | 2009-09-24 | Piston pressure-regulating high-sensitivity small-tension film-shaped biomaterial mechanic detector |
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| CN2009101909472A CN101666726B (en) | 2009-09-24 | 2009-09-24 | Piston pressure-regulating high-sensitivity small-tension film-shaped biomaterial mechanic detector |
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| CN101666726B CN101666726B (en) | 2011-02-16 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102125436A (en) * | 2011-04-15 | 2011-07-20 | 北京航空航天大学 | Device for measuring skin muscle tension |
| CN102657534A (en) * | 2012-05-17 | 2012-09-12 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102688046A (en) * | 2012-06-11 | 2012-09-26 | 上海市杨浦区中心医院 | Experimental animal hollow organ and vessel pressure-tolerant mechanics test device |
| CN103300817A (en) * | 2012-03-15 | 2013-09-18 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
| CN105699199A (en) * | 2016-03-30 | 2016-06-22 | 杭州亚慧生物科技有限公司 | Bursting strength detection device of sealant for surgical operation |
| CN106256332A (en) * | 2016-08-31 | 2016-12-28 | 桐庐洲济医疗器械有限公司 | Tendon braiding device is transplanted in Healing in Anterior Cruciate Ligament Reconstruction set |
| CN110132723A (en) * | 2019-04-23 | 2019-08-16 | 江苏科技大学 | Organization mechanics performance testing device and test method under a kind of imitative biological living environment |
| CN110301923A (en) * | 2019-07-01 | 2019-10-08 | 清华大学 | The micro- measuring system of bridge type mechanism applied to muscle stretch Mechanics Performance Testing |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69216292T2 (en) * | 1991-05-21 | 1997-06-05 | Jack Fisher | System and method for measuring mechanical properties of elastic materials |
| CN2102511U (en) * | 1991-11-07 | 1992-04-22 | 山东医科大学 | Measuring device of boilogical material mechanics |
| FR2806804B1 (en) * | 2000-03-22 | 2002-07-26 | Innothera Lab Sa | MEASUREMENT BENCH FOR THE STUDY OF THE RHEOLOGICAL BEHAVIOR OF SOFT MATERIALS, ESPECIALLY BIOMATERIALS OR PHYSIOLOGICAL TISSUES |
| CN100429499C (en) * | 2005-12-29 | 2008-10-29 | 中国人民解放军第三军医大学第三附属医院 | Apparatus for testing mechanical property of high-sensitivity small-tension membrane-like biomaterial |
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2009
- 2009-09-24 CN CN2009101909472A patent/CN101666726B/en active Active
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| CN102125436A (en) * | 2011-04-15 | 2011-07-20 | 北京航空航天大学 | Device for measuring skin muscle tension |
| CN103300817A (en) * | 2012-03-15 | 2013-09-18 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
| CN103300817B (en) * | 2012-03-15 | 2014-12-17 | 上海理工大学 | Blood vessel seal bursting pressure wireless measurement system |
| CN102657534A (en) * | 2012-05-17 | 2012-09-12 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102657534B (en) * | 2012-05-17 | 2014-03-19 | 上海理工大学 | Closed opening burst pressure measuring device for biological pipeline |
| CN102688046A (en) * | 2012-06-11 | 2012-09-26 | 上海市杨浦区中心医院 | Experimental animal hollow organ and vessel pressure-tolerant mechanics test device |
| CN105699199A (en) * | 2016-03-30 | 2016-06-22 | 杭州亚慧生物科技有限公司 | Bursting strength detection device of sealant for surgical operation |
| CN105699199B (en) * | 2016-03-30 | 2018-07-27 | 杭州亚慧生物科技有限公司 | A kind of surgical operation sealing agent BURSTING STRENGTH detection device |
| CN106256332A (en) * | 2016-08-31 | 2016-12-28 | 桐庐洲济医疗器械有限公司 | Tendon braiding device is transplanted in Healing in Anterior Cruciate Ligament Reconstruction set |
| CN110132723A (en) * | 2019-04-23 | 2019-08-16 | 江苏科技大学 | Organization mechanics performance testing device and test method under a kind of imitative biological living environment |
| CN110132723B (en) * | 2019-04-23 | 2021-07-27 | 江苏科技大学 | Device and method for testing tissue mechanical properties in bionic living body environment |
| CN110301923A (en) * | 2019-07-01 | 2019-10-08 | 清华大学 | The micro- measuring system of bridge type mechanism applied to muscle stretch Mechanics Performance Testing |
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