CN101658694A - Ophthalmologic contact lens jointing agent - Google Patents
Ophthalmologic contact lens jointing agent Download PDFInfo
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- CN101658694A CN101658694A CN200910175804A CN200910175804A CN101658694A CN 101658694 A CN101658694 A CN 101658694A CN 200910175804 A CN200910175804 A CN 200910175804A CN 200910175804 A CN200910175804 A CN 200910175804A CN 101658694 A CN101658694 A CN 101658694A
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- China
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- ophthalmologic
- contact lens
- jointing agent
- disinfectant
- agent
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Abstract
The invention relates to an ophthalmologic contact lens jointing agent, comprising ophthalmic gel substrate, disinfectant, osmotic-pressure regulating agent, pH value regulating agent and water whichare mixed and stirred to form a transparent gel preparation; the invention has proper viscosity and elasticity, is not easy to flow away and is easy to scatter, so that the ophthalmologic contact lensis easy and simple to place, the ophthalmologic contact lens jointing agent has better transparency, is favorable for inspection and laser therapy, has desinfektion, can avoid cross infection, effectively improves the present situation of inconvenience of use of ophthalmologic contact lens and easiness for spreading diseases, can relieve working pressure and working intensity of ophthalmologic laser therapy doctors to a large degree, can enhance comfort level of a patient, avoids medical disputes owing to cross infection, has the characteristics of crystal transparency, immobilization, good viscosity, good disinfection effect, no irritation, no peculiar smell, easy rinse and the like, can obviously improve the present situation that the application of existing ophthalmologic contact lenslacks appropriate jointing agent, the ophthalmologic contact lens jointing agent is convenient and comfortable for use, and is a competent aid to ophthalmologic doctors.
Description
Technical field:
The present invention relates to a kind of Ophthalmologic contact lens jointing agent.
Background technology:
Lead in ophthalmology section, various contact lenss are of many uses, comprise and checking and treatment, as check with three mirror contact lens, gonioscope, various ophthalmology laser treatment contact lenss etc., all contact lenss all need bridging agent when using, with deaeration, guarantee that light is not reflected, so that light or laser irradiation are to the position that needs to check or treat.Contact lens directly contacts eyes, and the frequency of utilization of contact lens is quite high, and twice use sometimes be a few minutes only at interval, and laser therapy does not allow to adopt the sterilization method with the effect of destruction plated film with the plated film of contact lens, the cross infection that this can cause the eye pathogen causes hospital infection.
Field of ophthalmology does not have special contact lens bridging agent at present, lays contact lens Shi doctor and generally uses antibiotic eye drop, normal saline etc., use viscoelastic agent with good conditionsi.
The thin easy loss of eye drop or normal saline, be not easy to play the effect of deaeration, cause contact lens to lay difficulty, and also want persistent pressure just can prevent air admission after laying successfully, the eye drop of loss or normal saline also can pollute patient's face and instrument and doctor's hands.The time need rotate contact lens with contact lens inspection and treatment, if air admission then needs to lay again, not have lubricated rotation to reach to lay contact lens repeatedly not only to bring misery and damage during rotation, also bring worries and poor efficiency to the doctor to the patient.And can cause intraocular pressure to raise to the contact lens pressurization, not only can cause discomforts such as patient's ophthalmic bloated, ophthalmalgia, even can cause the temporary transient obturation of retinal vessel to cause retina, optic nerve ischemia equivalent damage, severe patient can cause the damage of visual function.
The eye drop that uses, as the most frequently used Chloramphenicol Eye Drop, taste is very bitter, and regular meeting flows in patient's mouth from buccal or lacrimal passage during use, causes the patient suffering, interrupts sometimes checking or treatment.
Syringe dress viscoelastic agent costliness, for ophthalmologic operation designs, elasticity and viscosity all are not suitable as the contact lens bridging agent and use, and most of doctor is not easy to obtain.
At present the disinfectant measure of ophthalmology contact lens is limited, is to be limited by reasons such as frequency of utilization height, the optical effect that need keep in touch the mirror minute surface and protection plated films, can not adopt immersion, fumigates, sterilization method such as High Temperature High Pressure.Part doctor adopts 75% alcohol wipe sterilization, and this is not easy to accomplish safe sterilization, and because of contact lens frequency of utilization height, residual ethanol might damage eyes.
Present ophthalmologist, ophthalmology laser doctor particularly, need a kind of suitable Ophthalmologic contact lens jointing agent, bring great convenience and can increase work efficiency not only can for doctor's work, the patient is more comfortable, safer, but also the disinfectant function can be arranged, and can kill pathogenic microorganism, prevent cross infection.Present gel-like preparation being widely used at ophthalmology, safety, the comfortableness used have obtained clinical verification, the disinfectant that is applied to eye of safety also is applied in the conditioning liquid of contact lenses for a long time, effectiveness and safety have also obtained clinical checking, so use present technology and material can be produced the Ophthalmologic contact lens jointing agent that meets clinical requirement fully.
The patient with contact lens inspection or treatment after, conjunctiva can be obviously congested, causes patient's discomfort and outward appearance indecency, can add vasoconstrictor in the contact lens bridging agent, to avoid eye hyperemia behind the patient treatment.
Summary of the invention:
The object of the present invention is to provide a kind of Ophthalmologic contact lens jointing agent, the gained bridging agent has appropriate viscosity and elasticity, be not easy to run off and be easy to and disperse, make the ophthalmology contact lens lay easily, simple, has the transparency preferably, be beneficial to and check and laser therapy, and have disinfective action, can prevent cross infection.The present invention can effectively improve the ophthalmology contact lens and use inconvenience, is easy to pathophorous present situation, can alleviate ophthalmology laser treatment doctor's operating pressure and working strength significantly, can improve patient's comfort level, avoid the medical tangle that causes because of cross infection, to overcome above-mentioned deficiency.
The objective of the invention is to realize by following technical scheme:
Technical scheme provided by the invention is: Ophthalmologic contact lens jointing agent, the gel-type vehicle that it comprises is one or more the mixture in carbomer, hyaluronate sodium, the cellulose derivative, and cellulose derivative comprises hydroxyethyl-cellulose, hydroxypropyl cellulose etc.;
Described disinfectant is a kind of in biguanide and salt thereof, quaternary ammonium salt, the nanometer silver or their mixture, optional hexamethylene, chlorhexidine acetate in biguanide and the salt thereof, optional cetylpyridinium chloride, benzalkonium chloride, benzalkonium bromide etc. in the quaternary ammonium salt;
That described ophthalmic gel base should reach is transparent, do not flow, adhesiveness is good, be easy to characteristics such as removing, and content is 0.1-10.0wt%;
Described disinfectant should be able to effectively kill pathogenic microorganism, and the propagation that wards off disease can not stimulate, injure eyes again, and content is 0.0001～1.0wt%;
The present invention also contains osmotic pressure regulator, pH value regulator, water, can also increase vasoconstrictor, and osmotic pressure regulator is sodium chloride and/or mannitol; The pH value regulator is one or more mixed solutions in sodium hydrate aqueous solution, triethanolamine solution, ammonia, sodium carbonate liquor, sodium radio-phosphate,P-32 solution, boric acid, the hydrochloric acid;
The content of osmotic pressure regulator is that the content of 0.1-10.0wt%, pH value regulator is 0.1-10.0wt%, and all the other are distilled water;
The preparation method of Ophthalmologic contact lens jointing agent of the present invention: ophthalmic gel base 0.1-10.0wt%, disinfectant 0.0001～1.0wt%, osmotic pressure regulator 0.1-10.0wt%, water are mixed, stir, form gel, pH value regulator adjust pH is in 6.5～8.0 scopes, add water to volume required, stir, sterilization promptly gets Ophthalmologic contact lens jointing agent.
Adopt gained Ophthalmologic contact lens jointing agent of the present invention, have sparkling and crystal-clear transparent, do not flow, adhesiveness is good, Disinfection Effect is good, non-stimulated, free from extraneous odour, be easy to characteristics such as cleaning, can improve present ophthalmology contact lens significantly and use the present situation that lacks suitable bridging agent, not only easy to use, comfortable, and can prevent cross infection, be ophthalmologist's competent assistant.
The specific embodiment:
Embodiment:
A kind of Ophthalmologic contact lens jointing agent is characterized in that: bridging agent is the clear gel preparation, comprises ophthalmic gel base, disinfectant, osmotic pressure regulator, pH value regulator, and wherein each content is:
The content of ophthalmic gel base is 0.1-10.0wt%;
The content of disinfectant is 0.0001～1.0wt%;
The content of osmotic pressure regulator is 0.1-10.0wt%;
The content of pH value regulator is 0.1-10.0wt%.
Described ophthalmic gel base is one or more the mixture in carbomer, hyaluronate sodium, the cellulose derivative;
Described disinfectant is a kind of in poly hexamethylene biguanide and salt thereof, quaternary ammonium salt, the nanometer silver or their mixture;
The content of described osmotic pressure regulator is that the content of 0.1-10.0wt%, pH value regulator is 0.1-10.0wt%, and all the other are water;
Described osmotic pressure regulator is sodium chloride or mannitol, and the pH value regulator is one or more mixed solutions in sodium hydrate aqueous solution, triethanolamine solution, sodium carbonate liquor, sodium radio-phosphate,P-32 solution, boric acid, the hydrochloric acid;
A kind of preparation method of Ophthalmologic contact lens jointing agent is: ophthalmic gel base 0.1-10.0wt%, disinfectant 0.0001～1.0wt%, osmotic pressure regulator 0.1-10.0wt%, water are mixed, stir, form gel, pH value regulator adjust pH is in 6.5～8.0 scopes, add water to volume required, stir, sterilization promptly gets Ophthalmologic contact lens jointing agent.
The present invention further specifies with following embodiment, and the purpose of described embodiment is just illustrated the present invention, is not construed as limiting the invention.
Embodiment 1: get:
Carbomer 8.0 grams
Nanometer silver 0.02 gram
Mannitol 12.0 grams
10 milliliters～100 milliliters of 10% sodium hydroxide solutions
Distilled water adds to 1000 grams
More than prescription can obtain 1000 gram gels through preparation, is contact lens bridging agent of the present invention.Preparation method: get the recipe quantity carbomer and add an amount of distilled water, stir swelling; Mannitol is dissolved in the distilled water, filters the back and add in the gel-type vehicle, pH value is adjusted to 6.6～7.8 with 10% sodium hydroxide solution with nanometer silver, adding distil water to 1000 gram, the formation gel that stirs, filters at sterilization, and packing after the passed examination, packing are promptly.
Embodiment 2: get:
Hydroxyethyl-cellulose 15.0 grams
Nanometer silver 0.02 gram
Mannitol 12.0 grams
20 milliliters～100 milliliters of triethanolamine solutions
Distilled water adds to 1000 grams
More than prescription can obtain 1000 gram gels through preparation, is contact lens bridging agent of the present invention.Preparation method: get the recipe quantity hydroxyethyl-cellulose and be made into gel-type vehicle; Mannitol is dissolved in the distilled water, adds in the gel-type vehicle with nanometer silver after filtering, pH value is adjusted to 6.6～7.8 with triethanolamine solution, adding distil water to 1000 gram, the formation gel that stirs, sterilization, filtration, packing after the passed examination, packing are promptly.
Embodiment 3: get:
Hyaluronate sodium 10.0 grams
Hexamethylene 0.2 gram
Sodium chloride 10.0 grams
20 milliliters～100 milliliters of 10% sodium hydroxide solutions
Distilled water adds to 1000 grams
More than prescription can obtain 1000 gram gels through preparation, is contact lens bridging agent of the present invention.Preparation method: get the recipe quantity hyaluronate sodium and add an amount of distilled water, stir swelling; Hexamethylene, sodium chloride etc. is dissolved in the distilled water, filters the back and add in the gel-type vehicle, pH value is adjusted to 6.6～7.8 with 10% sodium hydroxide solution, adding distil water to 1000 gram, the formation gel that stirs, filters at sterilization, and packing after the passed examination, packing are promptly.
Gel is to be substrate with carbomer, hyaluronate sodium, cellulose derivative etc., have limpid transparent, do not flow, characteristics such as free from extraneous odour, tissue can absorb, very welcome at ophthalmology at present as the clinical practice dosage form, be widely used.
Disinfectant is poly hexamethylene biguanide and salt thereof, quaternary ammonium salt, nanometer silver etc., has broad-spectrum antibacterial action, gram positive bacteria, gram negative bacteria, Fusarium spp., Candida albicans etc. all there is kill capability, nanometer silver also has good killing effect to chlamydia trachomatis, above-mentioned various disinfectant is in ophthalmology and the extensive use of relevant clinical subject, as as contact lens disinfection agent, medicament for the eyes antiseptic even eye drop etc., be disinfectant safely and effectively through clinical verification.
Claims (6)
1, a kind of Ophthalmologic contact lens jointing agent is characterized in that: bridging agent is the clear gel preparation, comprises ophthalmic gel base, disinfectant, osmotic pressure regulator, pH value regulator, and wherein each content is:
The content of ophthalmic gel base is 0.1-10.0wt%;
The content of disinfectant is 0.0001～1.0wt%;
The content of osmotic pressure regulator is 0.1-10.0wt%
The content of pH value regulator is 0.1-10.0wt%.
2, a kind of Ophthalmologic contact lens jointing agent according to claim 1 is characterized in that: described ophthalmic gel base is one or more the mixture in carbomer, hyaluronate sodium, the cellulose derivative.
3, a kind of Ophthalmologic contact lens jointing agent according to claim 1 is characterized in that: described disinfectant is a kind of in biguanide and salt thereof, quaternary ammonium salt, the nanometer silver or their mixture.
4, a kind of Ophthalmologic contact lens jointing agent according to claim 1 is characterized in that: described osmotic pressure regulator is sodium chloride and/or mannitol.
5, a kind of Ophthalmologic contact lens jointing agent according to claim 1 is characterized in that: described pH value regulator is one or more mixed solutions in sodium hydrate aqueous solution, triethanolamine solution, sodium carbonate liquor, sodium radio-phosphate,P-32 solution, boric acid, the hydrochloric acid.
6, the preparation method of a kind of Ophthalmologic contact lens jointing agent according to claim 1 is: ophthalmic gel base 0.1-10.0wt%, disinfectant 0.0001～1.0wt%, osmotic pressure regulator 0.1-10.0wt%, water are mixed, stir, form gel, pH value regulator adjust pH is in 6.5～8.0 scopes, add water to volume required, stir, sterilization promptly gets Ophthalmologic contact lens jointing agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910175804A CN101658694A (en) | 2009-09-07 | 2009-09-07 | Ophthalmologic contact lens jointing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910175804A CN101658694A (en) | 2009-09-07 | 2009-09-07 | Ophthalmologic contact lens jointing agent |
Publications (1)
| Publication Number | Publication Date |
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| CN101658694A true CN101658694A (en) | 2010-03-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN200910175804A Pending CN101658694A (en) | 2009-09-07 | 2009-09-07 | Ophthalmologic contact lens jointing agent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019223748A1 (en) * | 2018-05-25 | 2019-11-28 | 爱博诺德(北京)医疗科技股份有限公司 | Viscoelastic agent material |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387919A (en) * | 2002-06-20 | 2003-01-01 | 上海卫康光学有限公司 | Composition for removing residual protein on flexible hydrophilic contact mirror effectrvely and its application |
| CN1389213A (en) * | 2002-06-20 | 2003-01-08 | 上海卫康光学有限公司 | Composite eye-moistening liquid and its application |
| CN1390606A (en) * | 2002-06-20 | 2003-01-15 | 上海卫康光学有限公司 | Composition for treaitng contact lens and its application |
| CN1629679A (en) * | 2003-12-16 | 2005-06-22 | 上海卫康光学有限公司 | Ophthalmic solution containing borneol and usage thereof |
| CN1769411A (en) * | 1997-11-26 | 2006-05-10 | 先进医用光学公司 | Contact lens cleaning compositions |
-
2009
- 2009-09-07 CN CN200910175804A patent/CN101658694A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1769411A (en) * | 1997-11-26 | 2006-05-10 | 先进医用光学公司 | Contact lens cleaning compositions |
| CN1387919A (en) * | 2002-06-20 | 2003-01-01 | 上海卫康光学有限公司 | Composition for removing residual protein on flexible hydrophilic contact mirror effectrvely and its application |
| CN1389213A (en) * | 2002-06-20 | 2003-01-08 | 上海卫康光学有限公司 | Composite eye-moistening liquid and its application |
| CN1390606A (en) * | 2002-06-20 | 2003-01-15 | 上海卫康光学有限公司 | Composition for treaitng contact lens and its application |
| CN1629679A (en) * | 2003-12-16 | 2005-06-22 | 上海卫康光学有限公司 | Ophthalmic solution containing borneol and usage thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019223748A1 (en) * | 2018-05-25 | 2019-11-28 | 爱博诺德(北京)医疗科技股份有限公司 | Viscoelastic agent material |
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Application publication date: 20100303 |