CN101658618B - Anti-alcoholism liver protecting compound preparation and applications thereof - Google Patents
Anti-alcoholism liver protecting compound preparation and applications thereof Download PDFInfo
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- CN101658618B CN101658618B CN2009101125287A CN200910112528A CN101658618B CN 101658618 B CN101658618 B CN 101658618B CN 2009101125287 A CN2009101125287 A CN 2009101125287A CN 200910112528 A CN200910112528 A CN 200910112528A CN 101658618 B CN101658618 B CN 101658618B
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Abstract
The invention discloses an anti-alcoholism liver protecting compound preparation and applications thereof. The anti-alcoholism liver protecting compound preparation is prepared by raw materials in the scope of the following weight portions: 120-600 portions of radix puerariae, 200-2400 portions of rhizoma smilacis glabrae, 120-600 portions of semen hoveniae, 40-360 portions of phyllanthus emblica, 40-360 portions of radix angelicae, and 2-10 portions of grape seed extractive with the content of procyanidolic oligomers more than or equal to 95%. The anti-alcoholism liver protecting compound preparation can be prepared into oral agent, capsules, tablets or granules according to conventional Chinese medicine preparation methods, and also can be prepared into health drink or oral liquid by adding seasoning. The invention is applicable to people in danger of chemical liver injury, especially people with alcoholic liver injury caused by more drinking, and has the efficacies of beauty and skin care.
Description
Technical field
The present invention relates to a kind of anti-alcoholism liver protecting compound preparation and application.
Background technology
Liver as the important detoxifcation organ of human body has Hepatic artery and hepatic vein double blood supply.Chemical liver injury is the hepatic injury that is caused by the chemical Hepatoxic substance, and these chemical substances comprise chemical toxicant and the some drugs in ethanol, the environment.Alcoholic liver disease can be divided into alcoholic liver steatosis, alcoholic hepatitis, alcoholic fibrosis, alcoholic cirrhosis according to the different state of an illness: the alcoholic liver steatosis is optimum reversible, hepatic necrosis can take place in alcoholic hepatitis, its 5 annual survival rate is 60%, and serious symptom alcoholic hepatitis such as untimely treatment, then 49% patient can be dead in some months, alcoholic fibrosis is the result of tissue necrosis, often causes liver cirrhosis.In chronic alcoholic, have 30% to develop into liver cirrhosis approximately.At present alcoholic cirrhosis is not still had specific short, 5 annual survival rates only are 50%, and have 10% liver cirrhosis person can develop into hepatocarcinoma.What bother is that alcoholic liver disease is invisible morbidity, and is very easily out in the cold.
Summary of the invention
The objective of the invention is provides a kind of anti-alcoholism liver protecting compound preparation and application at the influence of ethanol to hepatic injury.
The present invention realizes by following technical solution:
Described anti-alcoholism liver protecting compound preparation is pressed row weight portion scope proportion raw material and is made: Semen Vitis viniferae extract 2-10 part of Radix Puerariae 120-600 part, Rhizoma Smilacis Glabrae 200-2400 part, Semen Hoveniae (Fructus Hoveniae) 120-600 part, Fructus Phyllanthi 40-360 part, Radix Angelicae Dahuricae 40-360 part, Oligomeric Proanthocyanidins content 〉=95%.
Described anti-alcoholism liver protecting compound preparation can method of Chinese medicinal routinely be made oral agents, capsule, tablet, granule etc.
The application of anti-alcoholism liver protecting compound preparation of the present invention is: add flavoring agent and make (health care) beverage or oral liquid.
The present invention has the following advantages: the present invention has been applicable to chemical liver injury danger person; the more person that causes the alcoholic liver injury particularly drinks; by reducing the concentration of ethanol in blood; promote alcoholic acid removing; eliminate the interior excessive free radicals that produces of body after drinking, hinder the formation of lipid peroxide, thereby alleviated the damage of ethanol hepatic tissue; play assistant protection function, and the effect of beauty and skin care is arranged chemical liver injury.
The specific embodiment
Below further specify the present invention for example, and further sketch the beneficial effect of anti-alcoholism liver protecting compound preparation of the present invention by testing example.
Embodiment 1
Described anti-alcoholism liver protecting compound preparation is pressed row weight portion scope proportion raw material and is made:
Semen Vitis viniferae extract 2-10 part of Radix Puerariae 120-600 part, Rhizoma Smilacis Glabrae 200-2400 part, Semen Hoveniae (Fructus Hoveniae) 120-600 part, Fructus Phyllanthi 40-360 part, Radix Angelicae Dahuricae 40-360 part, Oligomeric Proanthocyanidins content 〉=95%.
Embodiment 2
(health care) beverage made by described anti-alcoholism liver protecting compound preparation adding flavoring agent or oral liquid mainly is to press the row raw materials in weight portion to make:
Semen Vitis viniferae extract 2-10 part of Radix Puerariae 120-600 part, Rhizoma Smilacis Glabrae 200-2400 part, Semen Hoveniae (Fructus Hoveniae) 120-600 part, Fructus Phyllanthi 40-360 part, Radix Angelicae Dahuricae 40-360 part, Oligomeric Proanthocyanidins content 〉=95%, neotame 12-500 part.
Embodiment 3
By embodiment 2 described (health care) beverages or oral liquid wherein each raw material consumption be:
300 parts of Radix Puerariaes, 600 parts of Rhizoma Smilacis Glabraes, 300 parts of Semen Hoveniae (Fructus Hoveniae)s, 180 parts of Fructus Phyllanthis, 120 parts of the Radixs Angelicae Dahuricae,
4.0 parts of the Semen Vitis viniferae extracts of Oligomeric Proanthocyanidins content 〉=95%, 20 parts of neotame.
Embodiment 4
By embodiment 2 described (health care) beverages or oral liquid wherein each raw material consumption be:
8.0 parts of the Semen Vitis viniferae extracts of 600 parts of Radix Puerariaes, 1200 parts of Rhizoma Smilacis Glabraes, 600 parts of Semen Hoveniae (Fructus Hoveniae)s, 360 parts of Fructus Phyllanthis, 240 parts of the Radixs Angelicae Dahuricae, Oligomeric Proanthocyanidins content 〉=95%, 500 parts of neotame.
Embodiment 5
The preparation method that described anti-alcoholism liver protecting compound preparation adding flavoring agent is made (health care) beverage or oral liquid is as follows:
1), Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Rhizoma Smilacis Glabrae, Fructus Phyllanthi, the Radix Angelicae Dahuricae by the regulation of relevant criterion through after the assay was approved, standby;
2), press formula proportion with Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Rhizoma Smilacis Glabrae, Fructus Phyllanthi after the Radix Angelicae Dahuricae batching, drops in the extraction pot, each 9-11 times of water gaging--10 times of water of preferred amounts soaked 100-140 minute--preferably 120 minutes time, extract merge extractive liquid, 2 times;
3), extracting solution concentrates, stop when the water yield is the 70%-80% of cumulative volume to steaming---preferred value 75%;
4), to add ethanol to its content be 65%-75%, preferred value 70%; Cooling was left standstill 11-13 hour; Preferred cooling time of repose 12 hours;
5), get the supernatant, steam and remove and reclaim ethanol, concentrated solution;
6), with the concentrated solution thin up to 0.04-0.1g crude drug/ml, cross 290-310 mesh sieve-preferred 300 mesh sieves then;
7), the Semen Vitis viniferae extract thin up being become content is that 1.5%-2.5% Semen Vitis viniferae extract solution adds; Preferred content is 2.0% Semen Vitis viniferae extract solution;
8), add flavoring agent--neotame, to setting sugariness;
9), fill;
10), in 100 ℃ of-120 ℃ of temperature (110 ℃ of preferred values), sterilized 25-35 minute--preferred value 30 minutes;
11), product is through putting in storage after the assay was approved.
The production technology of above-mentioned process using routine: lixiviate, concentrate, purify, concentrate, dilution, filtration, packing, sterilization, check, warehouse-in, wherein be diluted to filling process all at 300,000 grades of clean areas, production technology design and appointed condition are by national GMP requirement.Above-mentioned beverage or oral liquid comprehensively leach the plurality of health care functions composition in the raw material, bring into play its comprehensive health care, absorb soon, and produce effects is rapid, has added flavoring agent in liquid, and mouthfeel is good, and is easily accepted by people.Finished product packs through sterilization treatment, and steady quality is not perishable, and is unit dose package, carries, preserves and take conveniently.
Solution of the present invention is based on the understanding and the Therapeutic Principle of motherland's medical science to alcoholic liver disease, with reference to modern pharmacological research achievement, from the Chinese medicine treasure-house, filter out natural edible-plant, the screening of filling a prescription by theory of Chinese medical science, Traditional Chinese medical theory is thought, its pathogenesis: malicious pathogen impairing the liver, the liver failing to dredge the spleen, dysfunction of the spleen in transportation, endogenous damp formation, its method of treatment: the QI invigorating detoxifcation, soothing the liver being amusing, dampness removing is let out turbid.Make through reasonable process according to these theoretical elite following several raw materials, chemical liver injury is had assistant protection function.Screening by theory of Chinese medical science is filled a prescription filters out natural edible-plant, and its pharmacology is as follows:
Radix Puerariae (Radix Puerariae) is the root of the perennial fallen leaves liana of pulse family clay thing Herba Gelsemii Elegantis or Radix Puerariae rattan.Contain flavone compound in the Radix Puerariae and reach 12%, wherein mainly contain daidzin (daidzin), daidzein (7,4-dihydroxy isoflavone, daidzin is former) and puerarin.Radix Puerariae is sweet, hot, cool, returns lung, spleen, stomach warp, effect energy relieving muscles diaphoresis, and rash, the promoting the production of body fluid to quench thirst relieving restlessness, yang invigorating antidiarrheal, the treatment skin ulcer of invigorating blood circulation is relieved the effect of alcohol.
Contain a large amount of glucoses, organic acid in the fruit of the drying and ripening band meat rachis of Semen Hoveniae (Fructus Hoveniae) and the seed, inorganic salt, vitamin etc., Semen Hoveniae (Fructus Hoveniae) has clearing away heat and promoting diuresis, and the effect of alcoholic intoxication cures mainly diseases such as wine disease, dysphoria with smothery sensation, thirsty, vomiting.
The drunkenness dispelling liquid of forming by a certain percentage by Radix Puerariae and Semen Hoveniae (Fructus Hoveniae), test through the healthy volunteer, even confirm that low alcohol consumption also can cause part hematochemistry composition obviously to change, and drunkenness dispelling liquid can suppress alcohol metabolism to a certain extent, promote to drain and can correct the change of hematochemistry composition due to the ethanol.
Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra (Smilax glabra Roxb.), claims red Rhizoma Smilacis Glabrae again, and sweet in the mouth, light, flat is returned liver, stomach warp.Effect with dehumidifying, detoxifcation, easing joint movement.
Emblic subsystem Tibetan conventional crude drugs also is the medicinal plants of health care and disease cure.The Fructus Phyllanthi nature and flavor are sweet, sour, puckery, cool, attach to the lung and stomach meridians, and have clearing away heat and cooling blood, promoting the production of body fluid to quench thirst, effects such as promoting digestion and invigorating the stomach, preventing phlegm from forming and stopping coughing, protecting liver and detoxication.
The Radix Angelicae Dahuricae is the dry root of the samphire Radix Angelicae Dahuricae, and acrid in the mouth is warm in nature.The Radix Angelicae Dahuricae ball back dizziness and headache that in traditional traditional Chinese medical science, is used to take a shower, or the dizzy pain of wind syndrome of head, and sudden and violent cold first warm, the state of mind is unclear, and the head swoons etc.The Radix Angelicae Dahuricae also can be assisted other Effective Components of Chinese Herb except that effects such as the evacuation of pus of performance dampness, pain relieving, prevent long-term alcohol user's blood pressure, the rising of blood fat, prevents the generation of long-term alcohol user's cardiovascular and cerebrovascular disease.
Semen Vitis viniferae extract (Grape Proanthocyanidins GPC) is the polyphenol compound that extracts from Semen Vitis viniferae, mainly contain Oligomeric Proanthocyanidins (Oligomeric Proanthocyanidins, OPC).Semen Vitis viniferae extract has open production in factory on the market, and the present invention adopts is the solid product of the Semen Vitis viniferae extract of Oligomeric Proanthocyanidins content 〉=95% wherein.The traditional Chinese medical science thinks that Fructus Vitis viniferae is flat, sweet in the mouth is sour, can fill blood, and bone and muscle strengthening, the liver benefiting the moon, diuresis, relaxing muscles and tendons to promote blood circulation, the warming the stomach spleen invigorating, relieving restlessness is quenched one's thirst.Contained polyphenols is natural free radical scavenger in the Fructus Vitis viniferae, has very strong antioxidant activity, can adjust the function of liver cell effectively, resists or reduces their injury of radical pair.Procyanidin has strong oxidation resistance, in vivo its antioxidation, to remove the free radical ability be 50 times, ascorbic 20 times of vitamin E.Hepatic injury has prevention and therapeutical effect to Semen Vitis viniferae extract to ethanol, and carbon tetrachloride hepatic injury is also had certain therapeutical effect.
To what anti-alcoholism liver protecting compound preparation of the present invention carried out chemical liver injury there is the animal experiment study of assistant protection function according to us, presentation of results, anti-alcoholism liver protecting compound preparation of the present invention has defencive function to chemical liver injury.
Test example 1: drug toxicity animal experiment data:
Test material: anti-alcoholism liver protecting compound preparation of the present invention.
Test method: select 300 of rabbit, the male and female dual-purpose, body weight 1.9-3.0 kilogram is in harmonious proportion compound preparation of the present invention with eliminating cold for resuscitation water, and dosage is 2.5 kilograms, adopts the administration by gavage administration, and every day, secondary serve on 180 days, and every day, the observer exempted from situation.The result shows that after the rabbit perfusion, movable food is all normal, and medicine has no side effect.
Test example 2: data is put to the proof in clinical observation:
Test material: anti-alcoholism liver protecting compound preparation of the present invention.
Test objective: to the treatment curative effect and the safety of research alcoholic fatty liver inflammation.
48 routine alcoholic hepatitis patients are used anti-alcoholism liver protecting compound preparation of the present invention treated for 12 weeks, observe indexs such as treatment front and back symptom and blood fat, liver function, kidney merit, liver B ultrasonic and change.The result: after treating for 12 weeks, doing well,improvings such as patient's uncomfortable liver area, weak, abdominal distention, the treatment effective percentage is 95.83%; It is 91.67%, 89.58% that treatment back ALT, AST recover natural rate of interest, conclusion anti-alcoholism liver protecting compound preparation of the present invention can reduce non-alcoholic stellato-hepatitis patient TG, TC level, promote ALT, AST to take a turn for the better, improve hepatocyte inner lipid deposition, no Liver and kidney untoward reaction takes place.Row liver biopsy pathology controlled observation before and after above-mentioned treatment, find that anti-alcoholism liver protecting compound preparation of the present invention disappears to the hepatocyte inflammation of alcoholic liver disease, disappearing of becoming of the alleviating of hepatocellular degeneration, neutrophil infiltration, the necrosis of kitchen range shape or lamellar necrosis, cholestasis, liver fat, alleviating of hepatic fibrosis are all had good efficacy.
Show that by test to take this product safe and effective.
Above-mentioned anti-alcoholism liver protecting compound preparation and health beverage thereof also can play beautifying skin-protection function.Because skin care elder generation nourishing the liver; Because liver can make the operation of whole body QI and blood unimpeded, the effect of play promoting the circulation of blood, invigorating blood circulation by the mechanism of qi of conditioning human body.The emotion of the happy human body of liver energy makes QI and blood gentle, and is happy.When normal catharsis of liver and store blood, you are just glowing with health, happy, and eyes are bright, and fingernail is ruddy; During deficiency of liver-blood, you will lusterless complexions, gloomy tarnish; During depression of liver-QI, complexion will be livid purple, chloasma or the like occurs.Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Rhizoma Smilacis Glabrae, Fructus Phyllanthi and Radix Angelicae Dahuricae five kinds of Chinese medicine can pass through tonifying liver, transfer liver, nourishing the liver among the present invention, play enrich blood, nourish blood, promoting the circulation of blood, the function of invigorating blood circulation, add that Semen Vitis viniferae extract keeps skin smooth together, increase skin elasticity, postpone or reduce the appearance of wrinkle.Also help opposing by radiation-induced comedo, mottle and the reaction of alleviation cosmetic allergic contact dermatitis simultaneously.
Claims (5)
1. anti-alcoholism liver protecting compound preparation, it is characterized in that described anti-alcoholism liver protecting compound preparation is made by pressing row weight portion scope proportion raw material: Semen Vitis viniferae extract 2-10 part of Radix Puerariae 120-600 part, Rhizoma Smilacis Glabrae 200-2400 part, Semen Hoveniae (Fructus Hoveniae) 120-600 part, Fructus Phyllanthi 40-360 part, Radix Angelicae Dahuricae 40-360 part, Oligomeric Proanthocyanidins content 〉=95%.
2. anti-alcoholism liver protecting compound preparation according to claim 1 is characterized in that, described anti-alcoholism liver protecting compound preparation is the oral agents that method of Chinese medicinal is routinely made.
3. the application of the described anti-alcoholism liver protecting compound preparation of claim 1 is characterized in that, described anti-alcoholism liver protecting compound preparation adds flavoring agent and makes beverage or oral liquid.
4. the application of anti-alcoholism liver protecting compound preparation according to claim 3 is characterized in that, described beverage or oral liquor are as follows:
1), Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Rhizoma Smilacis Glabrae, Fructus Phyllanthi, the Radix Angelicae Dahuricae by the regulation of relevant criterion through after the assay was approved, standby;
2), press formula proportion with Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Rhizoma Smilacis Glabrae, Fructus Phyllanthi after the Radix Angelicae Dahuricae batching, drops in the extraction pot, each 9-11 times of water gaging soaked 100-140 minute, extracted merge extractive liquid, 2 times;
3), extracting solution concentrates, stop when the water yield is the 70%-80% of cumulative volume to steaming;
4), adding ethanol to its content is 65%-75%; Cooling was left standstill 11-13 hour;
5), get the supernatant, steam and remove and reclaim ethanol, concentrated solution;
6), with the concentrated solution thin up to 0.04-0.1g crude drug/ml, cross the 290-310 mesh sieve then;
7), the Semen Vitis viniferae extract thin up being become content is to add behind the 1.5%-2.5% Semen Vitis viniferae extract solution;
8), add flavoring agent--neotame, to setting sugariness;
9), fill;
10), in 100 ℃ of-120 ℃ of temperature, sterilized 25-35 minute;
11), product is through putting in storage after the assay was approved.
5. the application of anti-alcoholism liver protecting compound preparation according to claim 4 is characterized in that, in described beverage or the oral liquor:
In the step 2, be 10 times of water gagings, soak time is 120 minutes at every turn;
In the step 3, extracting solution concentrates, and is that 75% o'clock of cumulative volume stops to steaming the water yield;
In the step 4, adding ethanol to its content is 70%; The cooling time of repose is 12 hours;
In the step 6, select 300 mesh sieves;
In the step 7 the Semen Vitis viniferae extract thin up being become content is to add behind the 2% Semen Vitis viniferae extract solution;
In the step 10, sterilization is 30 minutes in 110 ℃ of temperature.
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| CN101946894B (en) * | 2010-03-25 | 2012-12-05 | 无锡市天赐康生物科技有限公司 | Health food having auxiliary protection function on chemical liver damage and preparation method thereof |
| CN102671066A (en) * | 2012-05-18 | 2012-09-19 | 江西农业大学 | Hangover-alleviating compound and preparation method thereof |
| CN104256772A (en) * | 2014-08-27 | 2015-01-07 | 冯素明 | Kudzu vine root anti-alcoholism beverage |
| CN108310137A (en) * | 2018-01-30 | 2018-07-24 | 安徽瑞达健康产业有限公司 | A kind of sobering-up composition and preparation method thereof |
| CN111357891A (en) * | 2020-03-20 | 2020-07-03 | 广东盐业健康产业发展有限公司 | Plant beverage containing artichoke and ginseng and preparation method thereof |
| CN111436603A (en) * | 2020-05-29 | 2020-07-24 | 山西振东五和健康科技股份有限公司 | Liver-protecting product and processing method thereof |
| CN115462490A (en) * | 2021-06-11 | 2022-12-13 | 仙乐健康科技股份有限公司 | Whitening composition and whitening use thereof |
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