CN101653126A - Mite-killing composition containing fenazaquin - Google Patents
Mite-killing composition containing fenazaquin Download PDFInfo
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- CN101653126A CN101653126A CN200910165909A CN200910165909A CN101653126A CN 101653126 A CN101653126 A CN 101653126A CN 200910165909 A CN200910165909 A CN 200910165909A CN 200910165909 A CN200910165909 A CN 200910165909A CN 101653126 A CN101653126 A CN 101653126A
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- fenazaquin
- mite
- piperazines
- clofentezine
- composition
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Abstract
The invention discloses a mite-killing composition comprising the effective components of fenazaquin and clofentezine, wherein the proportion of the fenazaquin and the clofentezine in parts by mass is20:1-1:50. The fenazaquin and the clofentezine are compounded, which has an obvious synergistic action and can lower the application quantity and delay the generation of the drug resistance of harmful mites. The invention can be used for preventing and treating the harmful mites on crops, such as fruit trees, cotton, vegetables, flowers and the like.
Description
Technical field
The present invention relates to a kind of miticide composition and application thereof, be specially fenazaquin and the composite miticide composition of another acaricidal activity composition with synergistic effect, and the application of said composition on control of pest mite.
Background technology
Fenazaquin: English common name Fenazaquin, chemical name: 4-spy-butyl benzene ethyl quinazoline, molecular formula: C
20H
22N
20Its structural formula is:
This medicine is the quinolines miticide, and orange tree, apple tree two spotted spider mite are had the better prevention effect, and the lasting period is long, to natural enemies security.Do not have cross resistance with existing miticide, be particularly suitable for preventing and treating the pest mite class that existing miticide is produced resistance.But it is higher that the agent of fenazaquin list is used to prevent and treat harmful mite cost, and the evil mite easily produces resistance.
Four mite piperazines: English common name Clofentezine, molecular formula: C
14H
8C
12N
4, belong to contact killing type organic nitrogen miticide, low toxicity.Strong to mite ovum lethality, to young mite, if mite also has stronger lethality.Can be suppressed to egg laying amount of mite and the incubation rate of being laid eggs, the lasting period is long, generally can reach 50-60 days.But four mite piperazines are to becoming the mite weak effect, and quick-acting is poor, 2 weeks just can reach the highest acaricidal activity behind the general medicine, and use can't be satisfied the control requirement to the evil mite separately.
The evil mite is because its breeding cycle is short, and breeding amount is big, and mobility is little, and selfing degree height is easy to generate resistance especially.Show that according to people's results of study to the Chunan County panonychus citri in 2007 such as Xaisur China local panonychus citri has improved 25 times to the resistance of pyridaben.In the serious zone of some mite classes harm, single agent control evil mite dosage is big, cost is high, weak effect, environmental pollution are serious.Avoid evil mite pesticide resistance to produce and solve the difficult problem that resistance evil mite becomes control of pest mite.Avoiding the evil mite to develop immunity to drugs and administer resistance evil mite by different cultivars medicament composite is a kind of effective and economic approach.
Summary of the invention
The purpose of this invention is to provide a kind of miticide composition that contains fenazaquin, said composition has obvious synergistic effect, can reduce dosage, delay the drug-fast generation of evil mite, and miticidal effect is good, drug cost is low.Another purpose of invention provides the application of said composition on control of pest mite.
The present invention is based on the bioactive further investigation to fenazaquin, and by a large amount of Toxicity Determination and field trial, unexpected discovery fenazaquin and four mite piperazines are composite, have the notable synergistic effect, and can delay the drug-fast generation of evil mite.The inventor proposes the fenazaquin compound acaricide composition in view of the above.
The present invention is achieved through the following technical solutions:
A kind of miticide composition that contains fenazaquin is characterized in that: active ingredient is fenazaquin and four mite piperazines, and the active ingredient fenazaquin is 20 with the ratio of the mass fraction of four mite piperazines: 1-1: 50.
Described miticide composition, wherein the better mass fraction ratio of active ingredient fenazaquin and four mite piperazines is 10: 1-1: 20.
Described miticide composition, its active ingredient total content is 5%-80%.
The present composition can adopt prior art, according to the control crop, residing environmental condition, prevent and treat method, the control cost requirement, active ingredient fenazaquin and four mite piperazines are added auxiliary agent and excipients make agricultural according to production technology well known by persons skilled in the art and go up available any formulation, preferred dosage form comprises: suspending agent, wetting powder and water dispersible granules.
Described miticide composition is characterized in that can be used for preventing and treating various mite pests on the crop, is particularly useful for preventing and treating Panonychus citri, Tetranychus cinnabarinus and Tetranychus urticae.
Beneficial effect of the present invention is: 1. two kinds of compositions have obvious synergistic effect in the composition, reduce effective ingredient consumption, improve preventive effect, reduce drug cost; 2. composition is made up of the different active ingredient of two class mechanism of action, has synergistic effect, can delay the drug-fast generation of evil mite, overcomes the defective of each single agent itself, and control is in the harmful mite in the different bearing phase of the cycles comprehensively; Lasting period long, reduce the whole growth medication number of times in season, reduce the control cost, be of value to ecology and environmental protection.
Embodiment
Content of the present invention is further described by following examples, but can not be considered as limitation of the present invention.
(1) prescription and preparation processing embodiment 1-8.Active ingredient adopts former medicine of 99% fenazaquin and the former medicine of 95% 4 mite piperazine in the embodiment of the invention.
Embodiment 1:42% fenazaquin clofentezine wettable powder
Fenazaquin 40.40g
Four mite piperazine 2.11g
Lauryl sodium sulfate (wetting agent) 3g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 5g
Kaolin (filler) is mended to 100g
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get 42% fenazaquin clofentezine wettable powder.(mass ratio of fenazaquin and four mite piperazines is 20: 1)
Embodiment 2:33% fenazaquin clofentezine suspension agent
Fenazaquin 30.30g
Four mite piperazine 3.16g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreeze) 4g
Polyethylene glycol (thickener) 1g
Silicone oil (defoamer) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine pulverized in advance and carrier, dispersant, defoamer, thickener etc. are added in the sand milling still, porphyrize mixes through high speed shear again, makes suspending agent.(mass ratio of fenazaquin and four mite piperazines is 10: 1)
Embodiment 3:50% fenazaquin clofentezine wettable powder
Fenazaquin 40.40g
Four mite piperazine 10.53g
Lauryl sodium sulfate (wetting agent) 3g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 5g
Kaolin (filler) is mended to 100g
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get 50% fenazaquin clofentezine wettable powder.(mass ratio of fenazaquin and four mite piperazines is 4: 1)
Embodiment 4:30% fenazaquin clofentezine suspension agent
Fenazaquin 15.15g
Four mite piperazine 15.79g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreeze) 4g
Polyethylene glycol (thickener) 1g
Silicone oil (defoamer) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine pulverized in advance and carrier, dispersant, defoamer, thickener etc. are added in the sand milling still, porphyrize mixes through high speed shear again, makes suspending agent.(mass ratio of fenazaquin and four mite piperazines is 1: 1)
Embodiment 5:30% fenazaquin clofentezine suspension agent
Fenazaquin 5.05g
Four mite piperazine 26.32g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreeze) 4g
Polyethylene glycol (thickener) 1g
Silicone oil (defoamer) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine pulverized in advance and carrier, dispersant, defoamer, thickener etc. are added in the sand milling still, porphyrize mixes through high speed shear again, makes suspending agent.(mass ratio of fenazaquin and four mite piperazines is 1: 5)
Embodiment 6:22% fenazaquin clofentezine suspension agent
Fenazaquin 2.02g
Four mite piperazine 21.05g
Lignosulfonates (dispersant) 4g
Ethylene glycol (antifreeze) 4g
Polyethylene glycol (thickener) 1g
Silicone oil (defoamer) 0.4g
Deionized water is mended to 100g
By the prescription requirement, the former medicine pulverized in advance and carrier, dispersant, defoamer, thickener etc. are added in the sand milling still, porphyrize mixes through high speed shear again, makes suspending agent.(mass ratio of fenazaquin and four mite piperazines is 1: 10)
Embodiment 7:42% fenazaquin clofentezine water dispersible granule
Fenazaquin 2.02g
Four mite piperazine 42.11g
Neopelex (wetting agent) 3g
Lignin sodium sulphate (dispersant) 4g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 2g
Urea (disintegrant) 5g
Diatomite (filler) is mended to 100g
Said mixture is evenly mixed, and comminution by gas stream adds suitable quantity of water and kneading, and the mixture pelleting of gained promptly gets 42% fenazaquin clofentezine water dispersible granule.(mass ratio of fenazaquin and four mite piperazines is 1: 20)
Embodiment 8:51% fenazaquin clofentezine water dispersible granule
Fenazaquin 1.01g
Four mite piperazine 52.63g
Neopelex (wetting agent) 3g
Lignin sodium sulphate (dispersant) 4g
Alkylnaphthalene sulfonate formaldehyde condensation products (dispersant) 2g
Urea (disintegrant) 5g
Diatomite (filler) is mended to 100g
Said mixture is evenly mixed, and comminution by gas stream adds suitable quantity of water and kneading, and the mixture pelleting of gained promptly gets 51% fenazaquin clofentezine water dispersible granule.(mass ratio of fenazaquin and four mite piperazines is 1: 50)
The above only is the better embodiment of part of the present invention, can not therefore be interpreted as the restriction to claim of the present invention.
(2) biological activity determination of the present composition and the test of pesticide effectiveness
1. Toxicity Determination
With the cotton tetranychid is subjects, employing leaf dish spray-on process (with reference to " NY/T 1154.13-2008 agricultural chemicals indoor bioassay test rule insecticide. the 13rd part: leaf dish spray-on process "), the synergistic effect size of mensuration fenazaquin and the composite different proportion of four mite piperazine miticides.Co-toxicity coefficient (CTC value) according to the abundant method calculation composition of Sun Yun:
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ reagent agent LC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Table 1 fenazaquin and the composite Toxicity Determination on the cotton tetranychid of four mite piperazines
| Handle | ??LC 50(mg/L) | ??ATI | ??TTI | ??CTC |
| Fenazaquin | ??12.36 | ??100 | ||
| Four mite piperazines | ??53.18 | ??23.24 | ||
| 20: four mite piperazines 1 of fenazaquin | ??8.43 | ??146.62 | ??96.34 | ??152.18 |
| 10: four mite piperazines 1 of fenazaquin | ??7.02 | ??176.07 | ??93.02 | ??189.28 |
| 4: four mite piperazines 1 of fenazaquin | ??6.91 | ??178.87 | ??84.65 | ??211.31 |
| 1: four mite piperazine 1 of fenazaquin | ??8.83 | ??139.98 | ??61.62 | ??227.16 |
| 1: four mite piperazine 5 of fenazaquin | ??16.47 | ??75.05 | ??36.03 | ??208.26 |
| 1: four mite piperazine 10 of fenazaquin | ??20.72 | ??59.65 | ??30.22 | ??197.40 |
| 1: four mite piperazine 20 of fenazaquin | ??24.58 | ??50.28 | ??26.90 | ??186.95 |
| 1: four mite piperazine 50 of fenazaquin | ??38.79 | ??31.86 | ??24.75 | ??128.76 |
The composite Toxicity Determination result of the test on the cotton tetranychid of fenazaquin and four mite piperazines shows, fenazaquin and four mite piperazines are composite to be 20 in the mass fraction ratio: 1-1: have synergistic effect between 50, especially 10: 1-1: between 20, synergistic effect is remarkable, and co-toxicity coefficient is greater than 180 (tables 1).
2, fenazaquin and the composite field efficiency test of four mite piperazines to the cowpea red spider
The field spray method is adopted in test, the field two spotted spider mite zone relatively uniformly takes place, every group of test medicine repeats for three times, repeats to select the 5 strain cowpeas object of making investigation at every turn, carry out the investigation of insect population radix, then carry out even spraying according to the extension rate and the application method of experimental scheme.Respectively at checking in 1 day, 7 days and 21 days behind the medicine, calculate field efficacy.
Fenazaquin and the composite field test results of four mite piperazines show, fenazaquin and four mite piperazines are composite to have synergistic effect.After the dispenser 1 day, each compound drug to the preventive effect of citrus red mite all more than 80%, minimum 80.2%, be up to 90.3%, be higher than the preventive effect 30.5% of four mite piperazine list agent, illustrate that the quick-acting of compound drug is significantly improved with respect to four mite piperazines; After the dispenser 21 days, the preventive effect of each compound drug was all more than 85%, and minimum is 86.3%, and is the highest by 98.6%, is higher than the preventive effect 78.7% of fenazaquin list agent, illustrates that the compound drug lasting effect has raising.
From result of the test, fenazaquin and four mite piperazines are composite, and under the situation that dosage reduces, quick-acting and lasting effect all have raising in various degree, show synergistic effect, can reduce dosing, delay the generation of evil mite pesticide resistance, reduce environmental pollution.
Claims (5)
1, a kind of miticide composition is characterized in that active ingredient contains fenazaquin and four mite piperazines, and the mass fraction ratio of fenazaquin and four mite piperazines is 20: 1-1: 50.
2, miticide composition according to claim 1 is characterized in that: the mass fraction ratio of fenazaquin and four mite piperazines is 10: 1-1: 20.
3, miticide composition according to claim 1 is characterized in that formulation is suspending agent, wetting powder and water dispersible granules.
4, the described composition of claim 1 is used for the mite pest control on the crop.
5, miticide composition according to claim 4 is particularly useful for preventing and treating Panonychus citri, Tetranychus cinnabarinus and Tetranychus urticae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910165909A CN101653126B (en) | 2009-08-12 | 2009-08-12 | Mite-killing composition containing fenazaquin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910165909A CN101653126B (en) | 2009-08-12 | 2009-08-12 | Mite-killing composition containing fenazaquin |
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| Publication Number | Publication Date |
|---|---|
| CN101653126A true CN101653126A (en) | 2010-02-24 |
| CN101653126B CN101653126B (en) | 2012-10-17 |
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|---|---|---|---|
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731228A (en) * | 2010-01-20 | 2010-06-16 | 东莞市瑞德丰生物科技有限公司 | Fenazaquin-containing acaricidal composition |
| CN105104407A (en) * | 2012-03-10 | 2015-12-02 | 陕西韦尔奇作物保护有限公司 | Efficient pesticidal composition |
| CN107372522A (en) * | 2017-08-31 | 2017-11-24 | 江西正邦生物化工有限责任公司 | A kind of composition pesticide containing fenazaquin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10353281A1 (en) * | 2003-11-14 | 2005-06-16 | Bayer Cropscience Ag | Combination of active ingredients with insecticidal and acaricidal properties |
| DE102007045922A1 (en) * | 2007-09-26 | 2009-04-02 | Bayer Cropscience Ag | Drug combinations with insecticidal and acaricidal properties |
-
2009
- 2009-08-12 CN CN200910165909A patent/CN101653126B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731228A (en) * | 2010-01-20 | 2010-06-16 | 东莞市瑞德丰生物科技有限公司 | Fenazaquin-containing acaricidal composition |
| CN105104407A (en) * | 2012-03-10 | 2015-12-02 | 陕西韦尔奇作物保护有限公司 | Efficient pesticidal composition |
| CN105104407B (en) * | 2012-03-10 | 2017-06-16 | 陕西韦尔奇作物保护有限公司 | A kind of Efficient insecticidal composition |
| CN107372522A (en) * | 2017-08-31 | 2017-11-24 | 江西正邦生物化工有限责任公司 | A kind of composition pesticide containing fenazaquin |
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| Publication number | Publication date |
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| CN101653126B (en) | 2012-10-17 |
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