CN101646466A

CN101646466A - System for maintaining sterile environment

Info

Publication number: CN101646466A
Application number: CN200880010273A
Authority: CN
Inventors: 大西二朗; 横井康彦; 岩间明文
Original assignee: Sanyo Electric Co Ltd
Current assignee: PHC Corp
Priority date: 2007-03-28
Filing date: 2008-03-27
Publication date: 2010-02-10

Abstract

It is intended to provide a system for maintaining sterile environment by which a sterile room can be sterilized within a shorter period of time than by the existing systems. A system for maintainingsterile environment comprising a sterile room (10) having an air inlet port (11) and an air outlet port (12), an HEPA filter (3) which is located so as to cover the air inlet port (11) or the air inlet port (11) and the air outlet port (12) of the sterile room (10), and a sterilizing agent-supply unit for supplying a sterilizing agent such as hydrogen peroxide into the sterile room (10), wherein the sterile room (10) is provided with a detoxifying agent-supply unit from which a detoxifying agent such as ozone is sprayed toward the HEPA filter (3).

Description

System for maintaining sterile environment

Technical field

The present invention relates to as isolator and clean bench and so on, can make its inner space keep the system for maintaining sterile environment of gnotobasis.

Background technology

Gnotobasis is meant, when carrying out certain operation, is used for avoiding the necessary material of this operation blended, unlimited environment near dust-free sterile in addition; Sterile working's platform is meant, operates the device of usefulness in the system for maintaining sterile environment in keeping the sterilizing room of gnotobasis, as representational system for maintaining sterile environment isolator that cell modulation uses etc., clean bench, safety cabinet etc. is arranged.

Isolator is meant, keep the physical segregation state of sterilizing room and its surrounding, simultaneously can be at the sterile working of aseptic in-house operation platform, an example as shown in figure 18, it is following structure, promptly utilizes the structure that can keep the isolation of sterilizing room under the state of closing Qianmen (101) by the operation of glove (102) (manipulable operating equipment in sterilizing room).

Clean bench is meant, control sterile working's platform of the aseptic condition of keeping sterilizing room by the air-flow in the sterilizing room, even the Qianmen of sterilizing room is half-open position (a manipulable operating equipment in sterilizing room) when operation, still can keep aseptic condition by said flow.

Safety cabinet is meant, control sterile working's platform of the aseptic condition of keeping sterilizing room by the air-flow in the sterilizing room, even the Qianmen of sterilizing room is half-open position (a manipulable operating equipment in sterilizing room) when operation, still can keep aseptic condition by said flow, and this air-flow is controlled the material that makes in the sterilizing room and can spread towards periphery.

In the past, in isolator, in cupboard (1) as shown in figure 16, formation has the sterilizing room (10) of air entry (11) and air vent (12), in sterilizing room (10), being provided with the trap particles in the mode of blocking air entry (11) and air vent (12) respectively is the HEPA filter (3) (3) of purpose.

In addition, in sterilizing room (10), being connected with supply is the hydrogen peroxide supply pipe (21) (sterilization material supply unit) of hydrogen peroxide from the sterilization material of hydrogen peroxide generator (2) (sterilization material generating unit), and the position is provided with hydrogen peroxide and removes filter (40) near air vent (12).

Further, in sterilizing room (10), be equipped with the sensor unit (90) of detected temperatures, humidity, concentration of hydrogen peroxide etc., its detection signal is supplied to control device (70), controls hydrogen peroxide generator (2) etc. by this control device (70).

In above-mentioned isolator, behind the EO in the sterilizing room (10), when entering next operation, from hydrogen peroxide generator (2) to sterilizing room (10) internal spraying hydrogen peroxide gas, make in the sterilizing room (10) to be full of hydrogen peroxide gas, come sterilize in the sterilizing room (10) (for example the Japanese publication communique of reference is 2002-360672 number).

Then, after sterilization process finishes, suck air from air entry (11) through HEPA filter (3), simultaneously the hydrogen peroxide gas in the sterilizing room (10) is discharged from air vent (12) through HEPA filter (3), and with the hydrogen peroxide gas in the air displacement sterilizing room (10), handle thereby implement gas displacement.

Summary of the invention

Yet, in the former isolator, as shown in figure 17, after utilizing the sterilization process of hydrogen peroxide spraying, need to implement long gas displacement and handle, there is the problem that the required time of sterilization in the sterilizing room (10) becomes extremely long.

The purpose of this invention is to provide system for maintaining sterile environment, this device can make asepticize in the sterilizing room in than the short in the past time.

Therefore, the inventor has carried out deep research in order to reach aforementioned purpose, found that, gas displacement in the isolator in the past behind the sterilization process is handled needs long reason to be, in sterilization process owing to make be full of in the sterilizing room hydrogen peroxide gas cause hydrogen peroxide with liquefaction attached on the HEPA filter, be difficult to this hydrogen peroxide is peeled off from the HEPA filter by gas displacement, thereby finished the present invention.

The 1st system for maintaining sterile environment of the present invention possesses: the sterilizing room with air entry and air vent; The micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room or air entry and air vent; And supply with the sterilization material supply unit of sterilization material to sterilizing room, and innoxious material supply unit is equipped with towards aforementioned micro particle catching filter, this innoxious material supply unit discharges the innoxious material that is used for innoxious aforementioned sterilization material.

Aforementioned innoxious material supply unit preferably discharges innoxious material towards the face of the aforementioned air-breathing oral-lateral of the aforementioned particulate filter that is provided with in the mode of blocking aforementioned air entry.

Aforementioned sterilization material supply unit is supplied with the liquid particle that contains the gas of sterilization material or be dissolved with sterilization material to sterilizing room; Aforementioned innoxious material supply unit sprays the liquid particle that contains the gas of innoxious material or dissolve innoxious material to aforementioned micro particle catching filter.

Here, aforementioned sterilization material is the 1st reactive oxygen species, and aforementioned innoxious material is the 2nd reactive oxygen species.And when aforementioned sterilization material was hydrogen peroxide or ozone, aforementioned innoxious material can be an alkaline water.

System for maintaining sterile environment according to the invention described above, for the innoxious material of micro particle catching filter direct injection that sterilization material is adhered to, thereby the sterilization material of micro particle catching filter decomposed effectively by this innoxious material, realized innoxious in the short period of time.

The 2nd system for maintaining sterile environment of the present invention possesses: the sterilizing room with air entry and air vent; The micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room or air entry and air vent; The irradiation apparatus of innoxious aforementioned sterilization material is equipped with and supply with the sterilization material supply unit of sterilization material, and towards aforementioned micro particle catching filter to sterilizing room.

Here, aforementioned sterilization material is a reactive oxygen species, and aforementioned irradiation apparatus is the combination of any or they of ultraviolet irradiation device, ultrasonic irradiation device, hot irradiation devices, infrared irridiation device.

System for maintaining sterile environment according to the invention described above, combination for the direct irradiation ultraviolet of the micro particle catching filter that sterilization material is adhered to, ultrasound wave, ultrared any or they, thereby the sterilization material of micro particle catching filter decomposed effectively, realized innoxious in the short period of time.

The 3rd system for maintaining sterile environment of the present invention possesses: the sterilizing room with air entry and air vent; The micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room or air entry and air vent; And supply with the sterilization material supply unit of sterilization material to sterilizing room, and aforementioned micro particle catching filter contains the innoxious material that is useful on innoxious aforementioned sterilization material.

System for maintaining sterile environment according to the invention described above, the micro particle catching filter that sterilization material is adhered to because of sterilization process, contain the innoxious material that is useful on innoxious sterilization material, thereby sterilization material and innoxious substance reaction and be decomposed, realizing innoxious in the short time.

In addition, according to sterile working's platforms such as isolator of the system for maintaining sterile environment that has used the invention described above, can be in than the short in the past time asepticize, can more effectively implement the operation in the sterilizing room.

According to system for maintaining sterile environment of the present invention, can in than the short in the past time, make asepticize in the sterilizing room.

Description of drawings

[Fig. 1] Fig. 1 is the figure of the structure of expression the 1st isolator of the present invention.

[Fig. 2] Fig. 2 is the perspective view of ozone sprayer unit.

[Fig. 3] Fig. 3 is the side view of ozone sprayer unit.

[Fig. 4] Fig. 4 is the front view of ozone sprayer unit.

[Fig. 5] Fig. 5 is the plane graph of ozone sprayer unit.

[Fig. 6] Fig. 6 is the figure of the structure of expression ozonator.

[Fig. 7] Fig. 7 is the figure of another structure of expression ozonator.

[Fig. 8] Fig. 8 is the figure of the structure of expression hydrogen peroxide generator.

[Fig. 9] Fig. 9 is the figure of another structure of expression hydrogen peroxide generator.

[Figure 10] Figure 10 is the figure of a plurality of examples of the sterilization treatment in this isolator of expression.

[Figure 11] Figure 11 is the figure of the structure of expression the 2nd isolator of the present invention.

[Figure 12] Figure 12 is the front view of the configuration of expression uviol lamp.

[Figure 13] Figure 13 is the plane graph of expression uviol lamp and reciprocating conveyor structure.

[Figure 14] Figure 14 is the figure of an example of the sterilization treatment in this isolator of expression.

[Figure 15] Figure 15 is the figure of the reactive chemistry formula of expression harmless treatment.

[Figure 16] Figure 16 is the figure that represents the structure of existing or the 3rd isolator of the present invention.

[Figure 17] Figure 17 is the figure of the existing sterilization treatment of expression.

[Figure 18] Figure 18 be isolator shown in Figure 16 central part above-below direction, with the sectional view of the vertical direction of paper.

[Figure 19] Figure 19 is the figure of structure of the 1st isolator of expression circulation sterilization formula.

[Figure 20] Figure 20 is the figure of structure that only represents to be provided with at air entry the 1st isolator of HEPA filter.

Symbol description

(1) cupboard

(10) sterilizing room

(11) air entry

(12) air vent

(2) hydrogen peroxide generator

(29) flow channel switching valve

(3) HEPA filter

(4) ozone, hydrogen peroxide are removed filter

(5) ozonator

(60) ozone supply pipe

(61) ozone aerosol apparatus

(7) control device

(8) uviol lamp

(9) sensor unit

The specific embodiment

Below, in isolator, implementing mode of the present invention, make specific description with reference to accompanying drawing.

＜embodiment 1 〉

In the 1st isolator of the present invention, as shown in Figure 1, formation has the sterilizing room (10) of air entry (11) and air vent (12) in cupboard (1), is provided with HEPA filter (3) (3) in the mode of blocking air entry (11) and air vent (12) respectively in sterilizing room (10).

And, in sterilizing room (10), be provided with ozone sprayer unit (6) (6) with two HEPA filters (3) (3) subtend, the ozone supply pipe (60) that two ozone sprayer units (6) (6) are used through ozone supply (innoxious material supply unit) is connected with ozonator (5) (sterilization material generating unit).

In addition, in sterilizing room (10), being connected with and supplying with sterilization material from hydrogen peroxide generator (2) is the hydrogen peroxide supply pipe (21) of hydrogen peroxide, between air vent (12) and HEPA filter (3), is provided with the ozone, the hydrogen peroxide that comprise active carbon etc. and removes filter (4).

Further, in sterilizing room (10), be equipped with the sensor unit (9) of detected temperatures, humidity, concentration of hydrogen peroxide, ozone concentration etc., its detection signal is supplied to control device (7), utilizes this control device (7) to control hydrogen peroxide generator (2), ozonator (5) etc.

As shown in Figure 2, ozone sprayer unit (6) possesses from the ramose a pair of ozone aerosol apparatus of ozone supply pipe (60) (61) (61).As shown in Figure 3, in each ozone aerosol apparatus (61), a plurality of nozzles (62) are offered towards HEPA filter (3).

As shown in Figure 4, the innoxious material that is used for innoxious sterilization material to the whole surface spray of HEPA filter (3) from a pair of ozone aerosol apparatus (61) (61) promptly is dissolved with the liquid mist (hereinafter referred to as ozone mist) of ozone.

In addition, as shown in Figure 5, a pair of ozone aerosol apparatus (61) (61) is arranged on the both ends of HEPA filter (3), each ozone aerosol apparatus (61) with the orthogonal direction of a plurality of broken lines of HEPA filter (3) on extend.Therefore, a plurality of broken lines from two ozone aerosol apparatus (61) (61) along HEPA filter (3) spray ozone gas or ozone mist, thereby with ozone supply each corner to HEPA filter (3).

Ozonator (5) can be made of ozone mist generator shown in Figure 6.In this ozone mist generator, under the control of control base (59), in electrolysis bath (54), supply with pure water (52) in the pure water jar (51) from manhole cover (53), utilize the ozone generating electrodes (56) in this electrolysis bath (54) to generate Ozone Water, by this Ozone Water being applied ultrasonic vibration, thereby produce ozone mist (58) from ultrasonic oscillator (57).This ozone mist (58) is supplied to the outside from ozone supply pipe (60).

In addition, ozonator (5) can also be made of ozonized gas generator shown in Figure 7.In this ozonized gas generator, supply with oxygen through feeder (502) to discharge type ozonator (503) from oxygen supply source (501), in discharge type ozonator (503), pass through the discharge generation ozone gas, this ozone gas is supplied to humidifier (505), and, obtain ozone (506) through humidification by pure water (504) humidification.

Hydrogen peroxide generator (2) can be made of hydrogen peroxide fog generator shown in Figure 8.In this hydrogen peroxide fog generator, under control based on control base (28), from the aquae hydrogenii dioxidi (23) of manhole cover (24) in hydrogen peroxide tank (25) is supplied with hydrogen peroxide water pot (22), by the aquae hydrogenii dioxidi in this hydrogen peroxide tank (25) being applied ultrasonic vibration, thereby produce hydrogen peroxide mist (27) from ultrasonic oscillator (26).

In addition, hydrogen peroxide generator (2) can also be made of hydrogen peroxide gasification device shown in Figure 9.In this hydrogen peroxide gasification device, to be drawn into the air of blowing pipeline (207) by the running of blowing fan (202) from air entry (201), through be arranged on the blowing pipeline (207) the exit element (205) and discharge from air vent (206), on the other hand, utilize pump (203) from hydrogen peroxide tank (204) suction aquae hydrogenii dioxidi, and be added drop-wise to element (205), thereby utilize air flow to make the aquae hydrogenii dioxidi gasification by this element (205).Then, the hydrogen peroxide gas of gasification is supplied to the outside from hydrogen peroxide supply pipe (21).

In the above-mentioned isolator, in order to implement the processing shown in Figure 10 (a) to sterilizing in the sterilizing room (10).As shown in the figure, before the sterilization process of in sterilizing room (10) internal spraying hydrogen peroxide gas or mist come sterilizing room (10), sterilizing, from ozone sprayer unit (6) spraying ozone mist or ozone gas from hydrogen peroxide generator (2).After sterilization process, implement and identical gas displacement in the past then.

Like this, before the sterilization process of in to sterilizing room (10), sterilizing, from ozone sprayer unit (6) spraying ozone mist or ozone gas, thereby make ozone attached on the HEPA filter (3), after sterilization process in, hydrogen peroxide is affixed to attached on the ozone on the HEPA filter (3).Its result, the mode shown in Figure 15 (a), ozone and hydroperoxidation generate oxygen and water, realize thus hydrogen peroxide is implemented harmless treatment.

Therefore, finish at short notice as the gas displacement behind the sterilization process of Figure 10 (a), the needed time of sterilizing shortens with comparing in the past significantly.

In addition, in the above-mentioned isolator, can also after the sterilization process shown in Figure 10 (b),, implement afterwards and identical gas displacement in the past from ozone sprayer unit (6) spraying ozone mist or ozone gas.

Like this,, also can in sterilization process, on the hydrogen peroxide that is attached on the HEPA filter 3, add ozone by only behind sterilization process, spray ozone mist or ozone gas, its result, hydrogen peroxide and ozone reaction generate oxygen and water.

Therefore, finish at short notice as the gas displacement of Figure 10 (b), the needed time of sterilizing shortens with comparing in the past significantly.

In addition, in the above-mentioned isolator, can also from ozone sprayer unit 6 spraying ozone mist or ozone gas, implement then and identical gas displacement in the past in the front and back of the sterilization process shown in Figure 10 (c).

The time of gas displacement is further shortened.

Further, in the above-mentioned isolator, can also be in the front and back of the sterilization process shown in Figure 10 (d) and process at sterilization process 1 time to repeatedly spray ozone mist or ozone gas, implement afterwards and former identical gas displacement.

The time of gas displacement is further shortened, and shorten with comparing in the past significantly the needed time of sterilizing.

In addition, in above-mentioned isolator, the hydrogen peroxide supply pipe (21) of supplying with the hydrogen peroxide that produces in the hydrogen peroxide generator (2) directly is connected with sterilizing room (10), but also can implement with following circulation sterilization method, as shown in figure 19, hydrogen peroxide generator (2) is arranged on the outside of sterilizing room (10), hydrogen peroxide comes sterilizing room (10) is sterilized according to the sequential loop of hydrogen peroxide generator (2), air-breathing oral-lateral HEPA filter (3), sterilizing room (10), exhaust side HEPA filter (3), hydrogen peroxide generator (2).

At this moment, as shown in figure 19, ozone supply pipe (60) is separately positioned on following four sides: the face of the sterilizing room side of the face of the sterilizing room side of air-breathing oral-lateral HEPA filter (3), the face of sterilizing room side, exhaust side HEPA filter (3), the face of exhaust side, the ozone of spraying is to carry out harmless treatment.In addition, ozone not necessarily need be sprayed on four sides at all, can spray according to the adhesion condition of the last hydrogen peroxide of HEPA filter (3) (3).The order of adhering to from big to small that HEPA filter (3) (3) is gone up hydrogen peroxide is: the face of the sterilizing room side of the face of the air-breathing oral-lateral of air-breathing oral-lateral HEPA filter (3), the face of sterilizing room side, exhaust side HEPA filter (3), the face of exhaust side, therefore preferably carry out harmless treatment, more preferably preferentially the face of the air-breathing oral-lateral of air-breathing oral-lateral HEPA filter (3) is carried out harmless treatment according to adhering to order.

In addition as shown in figure 20, this equally also is possible only being provided with in the isolator of HEPA filter (3) in air entry.

In addition, in above-mentioned isolator, use hydrogen peroxide (the 1st reactive oxygen species) as sterilization material, use ozone (the 2nd reactive oxygen species) as innoxious material, but as reactive oxygen species, with Oxidation from comprising to weak order by force: hydroxyl radical free radical, ozone, hypochlorous acid, hydrogen peroxide, superoxides, singlet oxygen etc., the combination that the oxidability of preferred the 2nd reactive oxygen species is bigger than the 1st reactive oxygen species, but also can be opposite combination.For example, also can use ozone (the 1st reactive oxygen species) as sterilization material, use hydrogen peroxide (the 2nd reactive oxygen species) as innoxious material.At this moment, ozone is stronger than the oxidability of hydrogen peroxide, but the mode shown in Figure 15 (a), ozone and hydroperoxidation generate oxygen and water, realize thus ozone is implemented harmless treatment.

When ozone and hydrogen peroxide combination, not only react to each other and the effect of the needed time shortening that obtains sterilizing, and because the powerful oxidability of the hydroxyl radical free radical that generates in the process before ozone and hydroperoxidation generation oxygen and water etc., thereby more effective sterilization functions is expected.

In addition, be hydrogen peroxide or ozone at sterilization material, when innoxious material is alkaline water, the hydroxyl ion in the alkaline water is decomposed by contacting with sterilization material.

＜embodiment 2 〉

In the 2nd isolator of the present invention, as shown in figure 11, formation has the sterilizing room (10) of air entry (11) and air vent (12) in cupboard 1, is provided with HEPA filter (3) (3) in the mode of blocking air entry (11) and air vent (12) respectively in sterilizing room (10).

Then, in sterilizing room (10), clip each HEPA filter (3) and be equipped with two uviol lamps (8) (8) in both sides respectively.

In addition, in sterilizing room (10), be connected with the hydrogen peroxide supply pipe (21) of hydrogen peroxide generator (2), between air vent (12) and HEPA filter (3), be provided with the ozone, the hydrogen peroxide that comprise active carbon etc. and remove filter (4).

Further, in sterilizing room (10), be equipped with the sensor unit (9) of detected temperatures, humidity, concentration of hydrogen peroxide etc., its detection signal is supplied to control device (7), controls hydrogen peroxide generator (2), uviol lamp (8) etc. by this control device (7).

As Figure 12 and shown in Figure 13, have the length longer slightly respectively at two uviol lamps (8) (8) that are equipped with up and down of HEPA filter (3) than the width of HEPA filter (3), its both ends are supported by reciprocating conveyor structure (81) (81).

Two sides along HEPA filter (3) moves back and forth two uviol lamps (8) (8) by the driving of reciprocating conveyor structure (81) (81), to the two sides irradiation ultraviolet of HEPA filter (3).

In above-mentioned isolator, in order to implement processing shown in Figure 14 to sterilizing in the sterilizing room (10).As shown in the figure, at first, from hydrogen peroxide generator (2) to sterilizing room (10) internal spraying hydrogen peroxide gas or mist and the sterilization process of sterilizing in beginning sterilizing room (10), after closing to an end preceding or finish, it opens all uviol lamps (8) immediately, this uviol lamp (8) is moved back and forth, come two sides irradiation ultraviolet HEPA filter (3).

Then, after sterilization process finished, beginning and same gas displacement in the past finished ultraviolet irradiation and gas displacement afterwards.

Like this, after sterilization process begins, by from the two sides irradiation ultraviolet of uviol lamp (8), thereby make action of ultraviolet radiation in attached to the hydrogen peroxide on the HEPA filter (3) to HEPA filter (3).Its result, the mode shown in Figure 15 (b), hydrogen peroxide is subjected to action of ultraviolet ray and generates oxygen and water, thereby realizes hydrogen peroxide is implemented harmless treatment.

This also is possible in the isolator of as shown in figure 19 sterilization cycle formula, can carry out irradiation according to the adhesion condition that HEPA filter (3) (3) is gone up hydrogen peroxide.The order of adhering to from big to small that HEPA filter (3) (3) is gone up hydrogen peroxide is: the face of the sterilizing room side of the face of the air-breathing oral-lateral of air-breathing oral-lateral HEPA filter (3), the face of sterilizing room side, exhaust side HEPA filter (3), the face of exhaust side, therefore preferably carry out harmless treatment, more preferably preferentially the face of the air-breathing oral-lateral of air-breathing oral-lateral HEPA filter (3) is carried out harmless treatment according to adhering to order.

In addition,, can also use ultrasonic irradiation device, infrared irridiation device or hot irradiation devices though in above-mentioned isolator, use ultraviolet irradiation device (irradiation apparatus), and their combination.The decomposition effect of ultraviolet irradiation is the highest, next is ultrasonic irradiation, hot irradiation, infrared irridiation.This is because during ultraviolet irradiation, and ultraviolet absorbs energy and cuts off interatomic bond, so efficient is good directly by the sterilization material molecule absorption.During ultrasonic irradiation, the interatomic bond of the pyrolysis cutting sterilization material that produces in the cavitation corrosion in solution (refer to diameter count the superhigh temperature of nanometer, highly compressed bubble), but also act on the interatomic bond of the molecule of the solvent that dissolves sterilization material simultaneously, so efficient is poor.In addition, when hot irradiation (for example heater etc.) or infrared irridiation, the thermal energy of being given at first is consumed in the evaporation of sterilization material and solvent, and thermal energy just is supplied to the decomposition of sterilization material afterwards, so deterioration of efficiency.

With the ultrasonic irradiation device during,, make sterilization material through thermal decomposition and innoxious by the heat that local vibration on filter produced to HEPA filter irradiation ultrasound wave.In addition, if form the structure of using HEPA filter nerve of a covering plate member, then can more effectively produce vibration, wherein said web plate parts are the web plate parts with the reticulated, open of the raw material formation of the exposure that can tolerate sterilization material.

In addition, though use hydrogen peroxide in the above-mentioned isolator, can also use ozone as sterilization material as sterilization material.At this moment, the mode shown in Figure 15 (c), ozone is subjected to action of ultraviolet ray and generates oxygen, implements the harmless treatment of ozone thus.

In addition, in the above-mentioned isolator, not only ozone or hydrogen peroxide are subjected to action of ultraviolet ray and the effect of the needed time shortening that obtains sterilizing, and decompose the powerful oxidability of the hydroxyl radical free radical that generates in the process that generates before the oxygen etc. owing to be subjected to action of ultraviolet ray at ozone or hydrogen peroxide, thereby more effective sterilization functions is expected.

＜embodiment 3 〉

In the 3rd isolator of the present invention, as shown in figure 16, formation has the sterilizing room (10) of air entry (11) and air vent (12) in cupboard (1), in the mode of blocking air entry (11) and air vent (12) respectively HEPA filter (3) (3) is set in sterilizing room (10).Different with former isolator, make it contain platinum at this HEPA filter surfaces sputter platinum in advance.

In addition, being connected with in sterilizing room (10) and supplying with sterilization material from hydrogen peroxide generator (2) is the hydrogen peroxide supply pipe (21) of hydrogen peroxide, between air vent (12) and HEPA filter (3), be provided with the ozone, the hydrogen peroxide that comprise active carbon etc. and remove filter (4).

In above-mentioned isolator, for to sterilizing in the sterilizing room (10), if in sterilizing room (10) internal spraying hydrogen peroxide gas or mist come sterilizing room (10), sterilize from hydrogen peroxide generator (2), the then catalytic reaction of the platinum that is contained owing to the HEPA filter attached to the hydrogen peroxide on the HEPA filter (3) elimination that is decomposed.

In addition, though use platinum in the above-mentioned isolator, can also be to contain the zinc complex of oxidant, Reducing agent, active carbon, platinum, ferrum oxide, copper oxide, manganese, catalase, fullerene, porphyrine (Port リ Off イリ Application), any one the above innoxious material in the chlorophyll compounds as the innoxious material that HEPA filter (3) is contained.

Among the innoxious material, platinum is excellence aspect usability, catalyst efficiency again.Next be the zinc complex of oxidant, Reducing agent, active carbon, ferrum oxide, copper oxide, manganese, fullerene, porphyrine in order.Catalase is effective when sterilization material is hydrogen peroxide.

The particularly zinc complex of porphyrine, chlorophyll compounds, near if the light the irradiation wavelength 400nm, then generation enzyme free radical on the complex surface is innoxious with sterilization material by this enzyme free radical, therefore preferably possesses near the light source of the light of irradiation wavelength 400nm.

Then, after sterilization process, if implement and same gas displacement in the past, the decomposition of the sterilization material due to the innoxious material that is contained by HEPA filter (3) then, make the gas displacement behind the sterilization process finish at short notice, the needed time of sterilizing shortens with comparing in the past significantly.

As shown in figure 20, this equally also is possible only being provided with in the isolator of HEPA filter (3) in air entry.

In addition, each structure of the present invention is not limited to above-mentioned embodiment, in the technical scope of putting down in writing in claims various distortion can be arranged.In addition, system for maintaining sterile environment of the present invention is not limited to isolator, can be applied to the various devices that clean bench etc. has sterilizing room.

Claims

1. system for maintaining sterile environment, this device possesses: the sterilizing room with air entry and air vent, the micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room or air entry and air vent, and sterilization material supply unit from sterilization material to described sterilizing room that supply with; It is characterized in that, be equipped with innoxious material supply unit towards described micro particle catching filter, this innoxious material supply unit discharges the innoxious material that is used for innoxious described sterilization material.

2. the described system for maintaining sterile environment of claim 1 is characterized in that, described innoxious material supply unit discharges innoxious material towards the face of the described air-breathing oral-lateral of the described particulate filter that is provided with in the mode of blocking described air entry.

3. claim 1 or 2 described system for maintaining sterile environment is characterized in that, described sterilization material supply unit is supplied with the liquid particle that contains the gas of described sterilization material or be dissolved with described sterilization material to sterilizing room; Described innoxious material supply unit is supplied with the liquid particle that contains the gas of described innoxious material or be dissolved with described innoxious material to described micro particle catching filter.

4. each described system for maintaining sterile environment in the claim 1～3 is characterized in that, described sterilization material is the 1st reactive oxygen species, and described innoxious material is the 2nd reactive oxygen species.

5. each described system for maintaining sterile environment in the claim 1～4 is characterized in that, described sterilization material is hydrogen peroxide or ozone, and described innoxious material is an alkaline water.

6. system for maintaining sterile environment, this device possesses: the sterilizing room with air entry and air vent, the micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room or air entry and air vent, and sterilization material supply unit from sterilization material to described sterilizing room that supply with; It is characterized in that, be equipped with the irradiation apparatus of innoxious described sterilization material towards described micro particle catching filter.

7. the described system for maintaining sterile environment of claim 6, it is characterized in that, described sterilization material is a reactive oxygen species, and described irradiation apparatus is the combination of any or they of ultraviolet irradiation device, ultrasonic irradiation device, hot irradiation devices, infrared irridiation device.

8. system for maintaining sterile environment, this device possesses: the sterilizing room with air entry and air vent, the micro particle catching filter that is provided with in the mode of the air entry that blocks this sterilizing room and air vent, and sterilization material supply unit from sterilization material to described sterilizing room that supply with; It is characterized in that described micro particle catching filter contains the innoxious material that is useful on innoxious described sterilization material.

9. the described system for maintaining sterile environment of claim 8, it is characterized in that described innoxious material contains more than the zinc complex of oxidant, Reducing agent, active carbon, platinum, ferrum oxide, copper oxide, manganese oxide, catalase, fullerene, porphyrine, in the chlorophyll compounds any one.