CN101642568B - Rhodiola root composition - Google Patents
Rhodiola root composition Download PDFInfo
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- CN101642568B CN101642568B CN2009100420562A CN200910042056A CN101642568B CN 101642568 B CN101642568 B CN 101642568B CN 2009100420562 A CN2009100420562 A CN 2009100420562A CN 200910042056 A CN200910042056 A CN 200910042056A CN 101642568 B CN101642568 B CN 101642568B
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Abstract
The invention discloses a rhodiola root composition which combines rhodiola root with isomaltose hypgather, ensures medical values of rhodiola root in multiple aspects, solves the problem that independently taking rhodiola root can result in discomfort of intestinal canals, and also improves the mouth feel. Compared with other similar products, the rhodiola root composition is not bitter. The composition can be made into any one of a food, a medicament and a preparation which is acceptable by a functional food, has the advantages of convenient carrying and taking as well as favorable mouth feel and adaptability, and is suitable to be used on the plateau or in the field. When taken on the plateau, the composition has the function of bidirectional regulation, and enhances the blood flow and the oxygen supply level of the encephalic regions so as to improve the symptom of oxygen lack. The preparation technique is simple, the quality difference between every two different batches of products is small, the product quality is uniform and stable, and the rhodiola root composition has favorable production practicability and practical value.
Description
Technical field
The present invention relates to medicine, health product and field of functional food, be specifically related to a kind of rhodiola root composition.
Background technology
Radix Rhodiolae is the dry root and rhizome of Crassulaceae plant Radix Rhodiolae, and its property is sweet, bitter, flat, benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma, and can be used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia and asthenia asthma etc.Crassulaceae Rhodida plant commonly used at present has: Radix Rhodiolae and Radix Rhodiolae etc., wherein Radix Rhodiolae has recorded into " Chinese pharmacopoeia version in 2005.
The main effective ingredient of modern medicine proof Radix Rhodiolae has rhodioloside, butyl alcohol, contains starch, protein, tannin, flavone compound, phenolic compound, micro-volatile oil and bioactive various trace elements ferrum, zinc etc. in addition.
The function of Radix Rhodiolae has: oxidation-resisting and caducity, protection cardiovascular system, protection cardiac muscle, raising immunity, radioprotective, antiviral antitumor, anti-liver and renal fibrosis or the like function; therefore Radix Rhodiolae all has crucial meaning at aspects such as military medicine, aviation medicine, sports medical science and sanipraticss, is a kind of worth Chinese medicine of further developing, studying.
Contain a large amount of tannins in the Radix Rhodiolae, various bacteria, virus all there is inhibitory action in various degree, make antibacterial can not obtain food nutrition and death, simultaneously normal intestinal flora such as bacillus bifidus and lactobacillus etc. also there is certain influence, therefore taking Radix Rhodiolae for a long time can influence the normal microecological environment of intestinal, tannin is inhibitory action to gastronintestinal system in addition, suppress intestinal peristalsis promoting, hindering gastric content divides a word with a hyphen at the end of a line to intestinal, also can suppress big enteral antibacterial amine and generate enzyme, the generation of blocking-up indoles, thus constipation caused.
Bifidus factor has positive effect to the propagation that promotes intestinal bifidobacteria and lactobacillus, the bifidus factor kind is more, as oligosaccharides, protein hydrolysate (as casein hydrolysate) and some protein substances, polysaccharose substance, short-chain fat acids material (as propanoic acid fat) and natural vegetable Chinese herbal medicine extract (as tea polyphenols, ginsenoside) or the like, wherein oligosaccharide is most widely used.
Oligosaccharide claims oligosaccharide or oligosaccharide again, be meant a class sugar of the straight or branched that 2～10 monosaccharide are formed by connecting by glycosidic bond, can be divided into ordinary oligosaccharide and functional oligose, functional oligose is a digestible oligosaccharide, mainly comprises oligofructose, mannooligo saccharide, oligomeric xylose, oligomeric galactose, lactulose, Raffinose, soybean oligo saccharide, isomaltulose, oligomeric isomaltose, oligo-Amorphophallus rivieri mannose etc.These functional oligoses energy selectivitys promote the propagation of probiotics; can work in coordination with other intestinal microbial populations and promote intestinal peristalsis promoting; the site of sticking by competition enteral nutrition and enteric epithelium surface; reduce the chance of adhering to of pathogenic bacterium; reduce the generation of poisonous fermented product; suppress pathogen and diarrhoea, the liver protecting, reduction serum cholesterol, enhancing immunity.
Have not yet to see the relevant report that Radix Rhodiolae and bifidus factor is combined common use.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of proliferation function that utilizes bifidus factor to intestinal bifidobacteria and lactobacillus is provided, thereby solved the impaired problem of the normal microecological environment of the intestinal that Radix Rhodiolae brought, guaranteed the rhodiola root composition that the Radix Rhodiolae drug effect is worth simultaneously.
Above-mentioned purpose of the present invention is achieved by following scheme:
Be worth height at the Radix Rhodiolae drug effect, but can bring the phenomenon of various bowel problems, the inventor obtains a kind of rhodiola root composition through research, and said composition comprises Radix Rhodiolae and bifidus factor.
In the above-mentioned composition, Radix Rhodiolae is earlier the Radix Rhodiolae medical material to be extracted to handle to obtain Radix Rhodiolae extract when utilization, is combined to form compositions with bifidus factor then; Radix Rhodiolae is extracted the operation that purification process prepares Radix Rhodiolae extract adopt those skilled in the art's routine operation get final product, the extracting method of present Radix Rhodiolae extract has decocting in water extraction, alcohol extracting method, supercritical CO
2Extraction, microwave extraction method and ultrasonic extraction or the like, the purification process of Radix Rhodiolae extract has water extract-alcohol precipitation method of purification, alcohol extracting-water precipitating method of purification, purification with macroreticular resin method and ultrafiltration purification method or the like, and the Radix Rhodiolae extract that any one method for extraction and purification obtains all can be realized the present invention.
In the above-mentioned composition, the effect of bifidus factor is exactly in order to solve the negative effect that tannin causes the intestines and stomach in the Radix Rhodiolae, therefore any one bifidus factor all can be realized the present invention, as oligofructose, mannooligo saccharide, oligomeric xylose, oligomeric galactose, lactulose, Raffinose, soybean oligo saccharide, isomaltulose, oligomeric isomaltose, Rhizoma amorphophalli Oligomeric manna sugar, casein hydrolysate, propanoic acid fat, tea polyphenols or ginsenoside or the like; Oligosaccharides or casein hydrolysate that the preferred those skilled in the art at present of bifidus factor use always, as oligofructose, mannooligo saccharide, oligomeric xylose, oligomeric galactose, lactulose, Raffinose, soybean oligo saccharide, isomaltulose, oligomeric isomaltose or Rhizoma amorphophalli Oligomeric manna sugar or the like, further preferred oligofructose, oligomeric xylose, oligomeric galactose, soybean oligo saccharide, isomaltulose, oligomeric isomaltose or casein hydrolysate or the like are more preferably oligofructose, oligomeric xylose, oligomeric galactose, oligomeric isomaltose or casein hydrolysate etc.
In the above-mentioned composition, the portfolio ratio of Radix Rhodiolae and bifidus factor is:
Count by weight: 2～10 parts of Radix Rhodiolaes;
0.3～20 part of bifidus factor.
The inventor is by discovering, the selection difference of bifidus factor kind, and Radix Rhodiolae is also different with bifidus factor needed ratio in compositions.
When bifidus factor is selected oligomeric isomaltose, count by weight, in the compositions of the present invention:
2～10 parts of Radix Rhodiolaes;
3～20 parts of bifidus factors.
When bifidus factor is selected oligofructose, count by weight, in the compositions of the present invention:
2～10 parts of Radix Rhodiolaes;
3～20 parts of bifidus factors.
When bifidus factor is selected oligomeric xylose, count by weight, in the compositions of the present invention:
2～10 parts of Radix Rhodiolaes;
0.3～10 part of bifidus factor.
When bifidus factor is selected casein hydrolysate, count by weight, in the compositions of the present invention:
2～10 parts of Radix Rhodiolaes;
3～8 parts of bifidus factors.
Used various adjuvants and additive when rhodiola root composition of the present invention can also add those skilled in the art's pharmacy, food processing are as filler or supplementary (microcrystalline Cellulose, mannitol, milk powder or lactose etc.), sweeting agent (A Siba is sweet, cyclamate or sucralose etc.), flavoring agent, lubricant, fluidizer (magnesium stearate or Pulvis Talci etc.), thickening agent (sodium carboxymethyl cellulose, arabic gum or gelatin, oligo-Amorphophallus rivieri mannose or gelatine powder etc.), antiseptic (sorbate or benzenpropanoic acid sodium etc.) or pH regulator agent etc.
The present invention at first obtains Radix Rhodiolae extract with Radix Rhodiolae with the processing of Chinese medicine extraction purifying process, then with Radix Rhodiolae extract and bifidus factor and adjuvant hybrid process commonly used, can be made into acceptable forms on any food, medicine and the functional food, in solid, semisolid and liquid oral medicines such as buccal tablet, granule, tabletting sugar, capsule, beverage, chewable tablet.
Compared with prior art, the present invention has following beneficial effect:
1. compositions of the present invention adopts Radix Rhodiolae and bifidus factor matched combined, not only guaranteed the many-sided medical value of Radix Rhodiolae, and solved the problem of taking the intestinal discomfort that Radix Rhodiolae can bring separately, and improved mouthfeel simultaneously, comparing with other like products does not have bitter taste;
2. the present invention is directed to different bifidus factors, according to the multiplication capacity of different bifidus factors to bacillus bifidus, adjusted the proportioning of bifidus factor and Radix Rhodiolae, determine multiple Radix Rhodiolae new compositions, applicable to preparing multiple oral formulations such as tablet, capsule, granule, fruit jelly, beverage etc. with bacillus bifidus multiplication capacity;
3. the Chinese medicine extraction purifying process that Radix Rhodiolae of the present invention adopts those skilled in the art to use always when in use, rhodioside content can reach 300mg/100g in the Radix Rhodiolae extract for preparing, rhodioside and butyl alcohol content are 2: 1～3: 1, substantially be consistent with crude drug, and kept neutral red Herba hylotelephii erythrosticti medical material fragrance;
4. product of the present invention has easy to carry, taking convenience, and mouthfeel is good, characteristics such as compliance is good are adapted at using under plateau and the field condition, take in the highlands, improved the blood flow and the oxygen supply level in these brain districts,, had dual regulation to improve anoxybiotic symptom;
5. rhodiola root composition of the present invention, its preparation technology is simple, and mass discrepancy is little between the different batches product, and uniform in quality is stable, has good production feasibility and using value.
Description of drawings
Fig. 1 is the influence contrast block diagram of Radix Rhodiolae extract group to intestinal bifidobacteria;
Fig. 2 is the influence contrast block diagram of rhodiola root composition group to intestinal bifidobacteria;
Wherein, 1 for before the low dose group filling stomach, and 2 for behind the low dose group filling stomach, and 3 is before middle dosage group is irritated stomach, and 4 is after middle dosage group is irritated stomach, and 5 for before the high dose group filling stomach, and 6 for behind the high dose group filling stomach, and 7 is before the blank group is irritated stomach, and 8 is after blank is organized the filling stomach.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done description further, but specific embodiment is not done any qualification to the present invention.
The decocting in water lixiviate and the water body alcohol deposition method of present embodiment prepare Radix Rhodiolae extract, are the routine operation of this area, and concrete steps are as follows:
Take by weighing the 1Kg Radix Rhodiolae, add 10 times of water, fry in shallow oil and carry 2 times, each 1 hour, extracting solution merged concentrated back precipitate with ethanol, removes the post precipitation ultrafiltration and concentration and obtains Radix Rhodiolae extractum.Rhodioside content is 0.76 quality % in this Radix Rhodiolae extract, and butyl alcohol content is 0.29 quality % (in the crude drug ratio).
The alcohol extracting method of present embodiment and alcohol extracting-water precipitating method of purification prepare Radix Rhodiolae extract, are the routine operation of this area, and concrete steps are as follows:
Get Radix Rhodiolae coarse powder 1Kg, add 70 volume % ethanol of 10 times of amounts, extract 2 times, each 1h filters merging filtrate, be concentrated into and be equivalent to crude drug 5g/mL, the centrifugal 15min of 5000r/min gets supernatant, concentrating under reduced pressure adds ethanol to pure content 70 quality %, leaves standstill 24h, filter, add 40 quality %NaOH solution adjust pHs to 8.0, leave standstill 24h, filter, collect and add the water stirring after filtrate concentrates, after cold preservation (4 ℃) is left standstill, the centrifugal supernatant of abandoning, precipitation, centrifugal, concentrate, be the required Radix Rhodiolae extract of present embodiment, rhodioside content is 0.77 quality % in measuring this Radix Rhodiolae extract, and butyl alcohol content is 0.38 quality % (in the crude drug ratio).
The supercritical CO of present embodiment
2Extraction is extracted and the precipitate with ethanol method of purification prepares Radix Rhodiolae extract, is the routine operation of this area, and concrete steps are as follows:
Get 1Kg after Radix Rhodiolae crushed and screened and knock down extractor, selecting ethanol for use is that entrainer carries out supercritical extraction.Extract takes out the back from knockout drum and adds dissolve with ethanol solution, and add powdered activated carbon decoloring, filtered while hot is removed active carbon, uses small amount of thermal alcoholic solution detergent active charcoal 3 times, and cleaning mixture and filtrate merge, leave standstill, rhodioside is that crystallization is separated out, and carries out recrystallization with 50 volume % alcoholic solution, and oven dry promptly gets Radix Rhodiolae extract, rhodioside content is 0.56 quality % in this Radix Rhodiolae extract, and butyl alcohol content is 0.26 quality % (in the crude drug ratio).
The closed microwave auxiliary extraction and the absorption with macroporous adsorbent resin purification of present embodiment prepare Radix Rhodiolae extract, are the routine operation of this area, and concrete steps are as follows:
Microwave auxiliary extraction: take by weighing the 1Kg Radix Rhodiolae, place cup in the special PFA (tetrafluoroethene), add microwave sampling behind 60% ethanol.After microwave heating treatment finishes, take out the sample preparation jar, extract is filtered, concentrate, purification by macroporous resin concentrates and prepares the required Radix Rhodiolae extract of present embodiment.
Result of the test shows: as medical material particle diameter＜40 μ m, the ethanol volume fraction is 55%, and microwave irradiation time is 2.5min, and the rhodioside extraction ratio is up to 0.78%, and butyl alcohol content is 0.28 quality %.(in the crude drug ratio)
The ultrasonic extraction ultrafiltration purification legal system of present embodiment is equipped with Radix Rhodiolae extract, is the routine operation of this area, and concrete steps are as follows:
Take by weighing the 1kg Radix Rhodiolae and place cup, soak 3h with 70 volume % alcoholic solution 50ml after, selection time 25min carries out ultrasonic extraction under 55 ℃ and ultrasonic power 300W condition, and extract is filtered, and concentrates and prepares the required Radix Rhodiolae extract of present embodiment.
With high effective liquid chromatography for measuring rhodioside concentration, resulting rhodioside content is 0.75 quality %, and butyl alcohol content is 0.27 quality % (in the crude drug ratio).
The combination of embodiment 6 Radix Rhodiolae extracts and oligomeric isomaltose
The rhodiola root composition of present embodiment comprises embodiment 1 preparation gained Radix Rhodiolae extract and oligomeric isomaltose, and its concrete preparation process is as follows:
Get oligomeric isomaltose 200g, microcrystalline Cellulose 50g, lactose 50g, mannitol 30g, steviosin 0.2g, mixing adds the Radix Rhodiolae extract that is equivalent to crude drug Radix Rhodiolae 30g and granulates, and dry granulate adds Pulvis Talci 8g, mixing; Tabletting can get the Radix Rhodiolae sheet.
In the rhodiola root composition of present embodiment, count 3 parts of Radix Rhodiolaes, 20 parts of oligomeric isomaltoses by weight.
The combination of embodiment 7 Radix Rhodiolae extracts and oligomeric isomaltose
The rhodiola root composition of present embodiment comprises embodiment 1 preparation gained Radix Rhodiolae extract and oligomeric isomaltose, and its concrete preparation process is as follows:
Get oligomeric isomaltose 120g, microcrystalline Cellulose 50g, lactose 50g, mannitol 30g, steviosin 0.2g, mixing adds the Radix Rhodiolae extract that is equivalent to crude drug Radix Rhodiolae 50g and granulates, and dry granulate adds Pulvis Talci 8g, mixing; Tabletting can get the Radix Rhodiolae sheet.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 12 parts of oligomeric isomaltoses by weight.
The combination of embodiment 8 Radix Rhodiolae extracts and oligomeric isomaltose
The rhodiola root composition of present embodiment comprises embodiment 1 preparation gained Radix Rhodiolae extract and oligomeric isomaltose, and its concrete preparation process is as follows:
Get oligomeric isomaltose 50g, microcrystalline Cellulose 50g, lactose 50g, mannitol 30g, steviosin 0.2g, mixing adds the Radix Rhodiolae extract that is equivalent to crude drug Radix Rhodiolae 80g and granulates, and dry granulate adds Pulvis Talci 8g, mixing; Tabletting can get the Radix Rhodiolae sheet.
In the rhodiola root composition of present embodiment, count 8 parts of Radix Rhodiolaes, 5 parts of oligomeric isomaltoses by weight.
Embodiment 9 rhodiola root compositions are to the influence of mice defecation
The laboratory animal of present embodiment is a secondary Kunming kind healthy male mice, body weight 20～23g.
Present embodiment is divided into three experimental grouies;
(1) Radix Rhodiolae extract group: embodiment 1 preparation gained Radix Rhodiolae extract;
(2) rhodiola root composition group; Embodiment 7 preparation gained rhodiola root compositions;
(3) blank group: water.
The dosage of three experimental grouies of present embodiment is selected:
(1) Radix Rhodiolae extract group: high dose (20g/kg.bw), middle dosage (10g/kg.bw), low dosage (5g/kg.bw);
(2) rhodiola root composition group: high dose (20g/kg.bw), middle dosage (10g/kg.bw), low dosage (5g/kg.bw);
(3) blank group: water.
Therefore present embodiment 7 experimental grouies altogether, every group of 10 animals.
Present embodiment with the head of mice just time, defecation grain number and defecation weight be index, investigate the influence of rhodiola root composition to the mice defecation, the result is as shown in table 1.
Each experimental group of table 1 is to the influence of mice defecation
As can be seen from Table 1, Radix Rhodiolae extract and the first defecation time of blank than obvious shortening mice increase total feces volume; And the rhodiola root composition group that is added with bifidus factor is compared with the Radix Rhodiolae extract group of not adding bifidus factor, and rhodiola root composition has tangible effect to shortening defecation time and increasing feces volume.
Embodiment 10 rhodiola root compositions are to the effect of mouse intestinal flora
The laboratory animal of present embodiment is a secondary Kunming kind healthy male mice, body weight 20～23g.
Present embodiment is divided into three experimental grouies;
(1) Radix Rhodiolae extract group: embodiment 1 preparation gained Radix Rhodiolae extract;
(2) rhodiola root composition group; Embodiment 7 preparation gained rhodiola root compositions;
(3) blank group: water.
The dosage of three experimental grouies of present embodiment is selected:
(1) Radix Rhodiolae extract group: high dose (20g/kg.bw), middle dosage (10g/kg.bw), low dosage (5g/kg.bw);
(2) rhodiola root composition group: high dose (20g/kg.bw), middle dosage (10g/kg.bw), low dosage (5g/kg.bw);
(3) blank group: water.
Therefore present embodiment 7 experimental grouies altogether, every group of 10 animals, to mouse stomach, once a day, and continuous 15 days, measure intestinal after irritating stomach on the 15th day, the result is as depicted in figs. 1 and 2.
As can be seen from Figure 1, compare with the blank group, the Radix Rhodiolae extract that does not add bifidus factor has tangible bacteriostasis, when removing harmful bacterium, also causes the disappearance of probiotic bacteria.
As can be seen from Figure 2, compare with the blank group, the Radix Rhodiolae extract that adds bifidus factor has tangible proliferation function to bacillus bifidus, and therefore, the interpolation of bifidus factor can remedy the intestinal discomfort problem that tannin is brought the destruction of bacillus bifidus in the Radix Rhodiolae.
The test of embodiment 11 mouthfeels
Present embodiment carries out comment index that mouthfeel judges to embodiment 7 preparation gained rhodiola root compositions and mainly contains sweet, bitter, puckery and all flavors such as the inherent local flavor of Radix Rhodiolae, shows with these 5 kinds of tastes of sweet taste, bitterness, astringent taste, Radix Rhodiolae local flavor and whole mouthfeel as the harmony index.
Comment number of degrees: v1 is not for giving prominence to (coordination), v2 for more not giving prominence to (coordination), v3 for relatively outstanding (coordination), v4 are very outstanding (coordination).
The evaluation number is every group 20 people, totally 120 people, and the result is as shown in table 2.
The evaluation of table 2 mouthfeel
| Sweet taste | Astringent taste | Bitterness | The Radix Rhodiolae local flavor | | |
| v1 | |||||
| 1 | 5 | 3 | |||
| |
6 | 13 | 14 | 1 | |
| v3 | 12 | 2 | 3 | 1 | 2 |
| |
1 | 18 | 18 |
As can be seen from Table 2, the mouthfeel of embodiment 7 preparation gained rhodiola root compositions is good, and compliance is good, does not have bitter taste substantially, sugariness is suitable, and the Radix Rhodiolae local flavor is strong.
The combination of embodiment 12 Radix Rhodiolae extracts and oligofructose
The rhodiola root composition of present embodiment comprises embodiment 2 preparation gained Radix Rhodiolae extract and oligofructoses, and its concrete preparation process is as follows:
Get oligofructose 200g, oligo-Amorphophallus rivieri mannose 50g, gelatin 50g, citric acid 20g, cyclamate 0.2g is dissolved in water, and adds to be equivalent in the extract of Radix Rhodiolae crude drug 30g, and allotment, standardize solution, filtration, sterilization, fill promptly get the Radix Rhodiolae drinks.
In the rhodiola root composition of present embodiment, count 3 parts of Radix Rhodiolaes, 20 parts of oligofructoses by weight.
The combination of embodiment 13 Radix Rhodiolae extracts and oligofructose
The rhodiola root composition of present embodiment comprises embodiment 2 preparation gained Radix Rhodiolae extract and oligofructoses, and its concrete preparation process is as follows:
Get oligofructose 120g, oligo-Amorphophallus rivieri mannose 50g, gelatin 50g, citric acid 20g, cyclamate 0.2g is dissolved in water, and adds to be equivalent in the extract of Radix Rhodiolae crude drug 50g, and allotment, standardize solution, filtration, sterilization, fill promptly get the Radix Rhodiolae drinks.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 12 parts of oligofructoses by weight.
The combination of embodiment 14 Radix Rhodiolae extracts and oligofructose
The rhodiola root composition of present embodiment comprises embodiment 2 preparation gained Radix Rhodiolae extract and oligofructoses, and its concrete preparation process is as follows:
Get oligofructose 50g, oligo-Amorphophallus rivieri mannose 50g, gelatin 50g, citric acid 20g, cyclamate 0.2g is dissolved in water, and adds the extract that is equivalent to Radix Rhodiolae crude drug 80g, and allotment, standardize solution, filtration, sterilization, fill promptly get the Radix Rhodiolae drinks.
In the rhodiola root composition of present embodiment, count 8 parts of Radix Rhodiolaes, 5 parts of oligofructoses by weight.
Embodiment 15
Test method (Radix Rhodiolae extract group selection embodiment 2 preparation gained Radix Rhodiolae extracts) according to embodiment 9～11 is carried out the effect of the influence of mice defecation, mouse intestinal flora and the coherent detection test of mouthfeel to embodiment 12 preparation gained rhodiola root compositions, and the result shows:
1. Radix Rhodiolae extract obviously shortens the defecation time first of mice, increases total feces volume; The rhodiola root composition that adds bifidus factor has more obvious effect to shortening defecation time and increasing feces volume, shortens defecation time 38.2% first, increases total feces volume 21.6%.
2. compare with the blank group, the Radix Rhodiolae extract that adds bifidus factor makes bacillus bifidus propagation 15.3%, therefore can remedy because the intestinal discomfort problem that tannin is brought the destruction of bacillus bifidus in the Radix Rhodiolae.
3. the rhodiola root composition mouthfeel is good, and compliance is good, does not have bitter taste, sour-sweet degree suitable, and the Radix Rhodiolae local flavor is strong.
The combination of embodiment 16 Radix Rhodiolae extracts and oligomeric xylose
The rhodiola root composition of present embodiment comprises embodiment 3 preparation gained Radix Rhodiolae extract and oligomeric xyloses, and its concrete preparation process is as follows:
Get microcrystalline Cellulose 30g, add oligomeric xylose 50g, lactose 20g, mixing, add the extract be equivalent to Radix Rhodiolae crude drug 30g, with the granulation of 1% Gonak, 50 ℃ of dryings 2 hours, granulate, add magnesium stearate 1g, the fill capsule can get Rhodiola rosea capsules.
In the rhodiola root composition of present embodiment, count 3 parts of Radix Rhodiolaes, 5 parts of oligomeric xyloses by weight.
The combination of embodiment 17 Radix Rhodiolae extracts and oligomeric xylose
The rhodiola root composition of present embodiment comprises embodiment 3 preparation gained Radix Rhodiolae extract and oligomeric xyloses, and its concrete preparation process is as follows:
Get microcrystalline Cellulose 30g, add oligomeric xylose 7g, lactose 20g, mixing, add the extract be equivalent to Radix Rhodiolae crude drug 50g, with the granulation of 1% Gonak, 50 ℃ of dryings 2 hours, granulate, add magnesium stearate 1g, the fill capsule can get Rhodiola rosea capsules.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 0.7 part of oligomeric xylose by weight.
The combination of embodiment 18 Radix Rhodiolae extracts and oligomeric xylose
The rhodiola root composition of present embodiment comprises embodiment 3 preparation gained Radix Rhodiolae extract and oligomeric xyloses, and its concrete preparation process is as follows:
Get microcrystalline Cellulose 30g, add oligomeric xylose 4g, lactose 20g, mixing, add the extract be equivalent to Radix Rhodiolae crude drug 80g, with the granulation of 1% Gonak, 50 ℃ of dryings 2 hours, granulate, add magnesium stearate 1g, the fill capsule can get Rhodiola rosea capsules.
In the rhodiola root composition of present embodiment, count 8 parts of Radix Rhodiolaes, 0.4 part of oligomeric xylose by weight.
Embodiment 19
Embodiment 18 preparation gained rhodiola root compositions are carried out the coherent detection test of the effect of the influence of mice defecation, mouse intestinal flora according to the test method (Radix Rhodiolae extract group selection embodiment 3 preparation gained Radix Rhodiolae extracts) of embodiment 9～11, the result shows
1. rhodiola root composition shortens defecation time 33.1% first, increases total feces volume 18.3%.
2. compare with the blank group, rhodiola root composition makes bacillus bifidus propagation 10.4%, therefore can remedy because the intestinal discomfort problem that tannin is brought the destruction of bacillus bifidus in the Radix Rhodiolae.
The combination of embodiment 20 Radix Rhodiolae extracts and oligomeric galactose
The rhodiola root composition of present embodiment comprises embodiment 4 preparation gained Radix Rhodiolae extract and oligomeric galactoses, and its concrete preparation process is as follows:
Get oligomeric galactose 150g, add lactose 70g, mannitol 30g, sucralose 1g, mixing adds the extract that is equivalent to Radix Rhodiolae crude drug 30g, granulate with 1% carboxymethylcellulose sodium solution, and 50 ℃ of dryings, granulate gets the Radix Rhodiolae granule.
In the rhodiola root composition of present embodiment, count 3 parts of Radix Rhodiolaes, 15 parts of oligomeric xyloses by weight.
The combination of embodiment 21 Radix Rhodiolae extracts and oligomeric galactose
The rhodiola root composition of present embodiment comprises embodiment 4 preparation gained Radix Rhodiolae extract and oligomeric galactoses, and its concrete preparation process is as follows:
Get oligomeric galactose 100g, add lactose 70g, mannitol 30g, sucralose 1g, mixing adds the extract that is equivalent to Radix Rhodiolae crude drug 50g, granulate with 1% carboxymethylcellulose sodium solution, and 50 ℃ of dryings, granulate gets the Radix Rhodiolae granule.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 10 parts of oligomeric galactoses by weight.
The combination of embodiment 22 Radix Rhodiolae extracts and oligomeric galactose
The rhodiola root composition of present embodiment comprises embodiment 4 preparation gained Radix Rhodiolae extract and oligomeric galactoses, and its concrete preparation process is as follows:
Get oligomeric galactose 50g, add lactose 70g, mannitol 30g, sucralose 1g, mixing adds the extract that is equivalent to Radix Rhodiolae crude drug 80g, granulate with 1% carboxymethylcellulose sodium solution, and 50 ℃ of dryings, granulate gets the Radix Rhodiolae granule.
In the rhodiola root composition of present embodiment, count 8 parts of Radix Rhodiolaes, 5 parts of oligomeric galactoses by weight.
Embodiment 23
Test method (Radix Rhodiolae extract group selection embodiment 4 preparation gained Radix Rhodiolae extracts) according to embodiment 9～11 is carried out the effect of the influence of mice defecation, mouse intestinal flora and the coherent detection test of mouthfeel to embodiment 22 preparation gained rhodiola root compositions, and the result shows:
1. rhodiola root composition has more obvious effect to shortening defecation time and increasing feces volume, shortens defecation time 30.2% first, increases total feces volume 18.5%.
2. compare with the blank group, the Radix Rhodiolae extract that adds bifidus factor makes bacillus bifidus propagation 12.4%.
3. the rhodiola root composition mouthfeel is good, and compliance is good, does not have bitter taste, sugariness suitable, and the Radix Rhodiolae local flavor is strong.
The combination of embodiment 24 Radix Rhodiolae extracts and casein hydrolysate
The rhodiola root composition of present embodiment comprises embodiment 5 preparation gained Radix Rhodiolae extract and casein hydrolysates, and its concrete preparation process is as follows:
Get casein hydrolysate 70g, whole milk powder 50g, lactose 80g, mannitol 50g, the sweet 5g mixing of A Siba adds the extract that is equivalent to Radix Rhodiolae crude drug 30g, and 2% gelatin solution is granulated, 50 ℃ of dryings, granulate, tabletting gets rhodiola rosea chewable tablets.
In the rhodiola root composition of present embodiment, count 3 parts of Radix Rhodiolaes, 7 parts of casein hydrolysates by weight.
The combination of embodiment 25 Radix Rhodiolae extracts and casein hydrolysate
The rhodiola root composition of present embodiment comprises embodiment 5 preparation gained Radix Rhodiolae extract and casein hydrolysates, and its concrete preparation process is as follows:
Get casein hydrolysate 50g, whole milk powder 50g, lactose 80g, mannitol 50g, the sweet 5g mixing of A Siba adds the extract that is equivalent to Radix Rhodiolae crude drug 50g, and 2% gelatin solution is granulated, 50 ℃ of dryings, granulate, tabletting gets rhodiola rosea chewable tablets.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 5 parts of casein hydrolysates by weight.
The combination of embodiment 26 Radix Rhodiolae extracts and casein hydrolysate
The rhodiola root composition of present embodiment comprises embodiment 5 preparation gained Radix Rhodiolae extract and casein hydrolysates, and its concrete preparation process is as follows:
Get casein hydrolysate 30g, whole milk powder 50g, lactose 80g, mannitol 50g, the sweet 5g mixing of A Siba adds the extract that is equivalent to Radix Rhodiolae crude drug 80g, and 2% gelatin solution is granulated, 50 ℃ of dryings, granulate, tabletting gets rhodiola rosea chewable tablets.
In the rhodiola root composition of present embodiment, count 8 parts of Radix Rhodiolaes, 3 parts of casein hydrolysates by weight.
Embodiment 27
Test method (Radix Rhodiolae extract group selection embodiment 5 preparation gained Radix Rhodiolae extracts) according to embodiment 9～11 is carried out the effect of the influence of mice defecation, mouse intestinal flora and the coherent detection test of mouthfeel to embodiment 25 preparation gained rhodiola root compositions, and the result shows:
1. rhodiola root composition shortens defecation time 26.5% first, increases total feces volume 19.2%.
2. compare with the blank group, the Radix Rhodiolae extract that adds bifidus factor makes bacillus bifidus propagation 11.5%.
3. the rhodiola root composition compliance is good, does not have bitter taste, sugariness suitable substantially, and the Radix Rhodiolae local flavor is strong.
The combination of embodiment 28 Radix Rhodiolae extracts and soybean oligo saccharide
The rhodiola root composition of present embodiment comprises embodiment 1 preparation gained Radix Rhodiolae extract and soybean oligo saccharide, and its concrete preparation process is as follows:
Get soybean oligo saccharide 120g, add microcrystalline Cellulose 60g, cattle colostrums 50g, carrageenan 10g, an amount of, the mannitol 50g of lemon yellow pigment, mixing adds the extract that is equivalent to Radix Rhodiolae crude drug 50g, and add and granulate, drying, granulate gets the Radix Rhodiolae granule.
In the rhodiola root composition of present embodiment, count 5 parts of Radix Rhodiolaes, 12 parts of soybean oligo saccharide by weight.
Preparation gained rhodiola root composition is carried out the effect of the influence of mice defecation, mouse intestinal flora and the coherent detection test of mouthfeel, and the result shows: said composition shortens defecation time 36.3% first, increases total feces volume 16.9%.Compare with matched group, the Radix Rhodiolae extract that adds bifidus factor makes bacillus bifidus propagation 13.7%, with the matched group that does not add bifidus factor significant difference is arranged.The sample mouthfeel is good, and compliance is good, does not have bitter taste, sugariness suitable substantially, and the Radix Rhodiolae local flavor is strong.
Claims (6)
1. a rhodiola root composition is characterized in that said composition comprises Radix Rhodiolae extract and bifidus factor; Described bifidus factor is oligomeric isomaltose, oligofructose, oligomeric xylose, oligomeric galactose, casein hydrolysate or soybean oligo saccharide; Described Radix Rhodiolae extract calculates according to the former medicine weight of Radix Rhodiolae and the weight ratio of various bifidus factors is: 5 parts of Radix Rhodiolaes, 12 parts of soybean oligo saccharide; Or 3～8 parts of Radix Rhodiolaes, 5～12 parts of oligomeric isomaltoses; Or 3～8 parts of Radix Rhodiolaes, 5～20 parts of oligofructoses; Or 5 parts of Radix Rhodiolaes, 10 parts of oligomeric galactoses; Or 8 parts of Radix Rhodiolaes, 5 parts of oligomeric galactoses; Or 3～8 parts of Radix Rhodiolaes, 3～7 parts of casein hydrolysates; Or Radix Rhodiolae 3-8 part, oligomeric xylose 0.4-5 part.
2. according to the described compositions of claim 1, it is characterized in that said composition also comprises filler, supplementary, sweeting agent, flavoring agent, lubricant, fluidizer, thickening agent, antiseptic or pH regulator agent.
3. according to the described compositions of claim 1, it is characterized in that being the granule form.
4. according to the described compositions of claim 1, it is characterized in that being tablet form.
5. according to the described compositions of claim 1, it is characterized in that being capsule form.
6. according to the described compositions of claim 1, it is characterized in that being drink form.
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| CN2009100420562A CN101642568B (en) | 2009-08-21 | 2009-08-21 | Rhodiola root composition |
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| CN2009100420562A CN101642568B (en) | 2009-08-21 | 2009-08-21 | Rhodiola root composition |
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| CN107058431B (en) * | 2017-05-09 | 2020-10-27 | 王智森 | Method for producing salidroside by deep liquid fermentation of salidroside |
| CN111802613B (en) * | 2020-07-14 | 2022-10-11 | 广东老中医保健食品有限公司 | Ginsenoside taste-masking agent, ginsenoside-containing composition with barley fragrance, buccal tablet and preparation method thereof |
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