CN101623373B

CN101623373B - Traditional Chinese medicine composition for treating psoriasis and preparation method thereof

Info

Publication number: CN101623373B
Application number: CN2009100657898A
Authority: CN
Inventors: 周大红
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-08-14
Filing date: 2009-08-14
Publication date: 2011-02-09
Anticipated expiration: 2029-08-14
Also published as: CN101623373A

Abstract

The invention belongs to the technical field of the traditional Chinese medicine, which in particular discloses a traditional Chinese medicine composition for treating psoriasis and a preparation method thereof. The traditional Chinese medicine composition is prepared from various following raw material medicines according to parts by weight: 30-50 parts of rumex japonicus root, 15-30 parts of goldenlarch bark, 6-15 parts of chaulmoogra kernel, 6-15 parts of centipede, 3-15 parts of cantharis, 0.3-1 part of mercurous chloride, 10-30 parts of calcined white alum, 10-15 parts of zanthoxylum, 15-50 parts of kuhseng, 15-30 parts of artemisia leaf, 15-30 parts of cnidium fruit, 15-30 parts of erythrina bark and 15-30 parts of dittany bark. The preparation method comprises the following steps: grinding the 13 kinds of traditional Chinese medicine raw material medicines into fine powder together, adding medical alcohol, taking soaking liquid after soaking for 2-7 days, and obtaining an externally-applied liquid medicine. The traditional Chinese medicine composition has the effects of eliminating toxic material, destroying parasites, astringing dampness, promoting wound healing, eliminating dampness, relieving itching, eradicating blood stasis, reducing the stagnation, dispersing pathogenic wind, dispelling cold, calming the endopathic wind, relieving spasm, smoothing collaterals and alleviating pain and has the advantages of short treatment course and precise curative effect on four types of psoriasis, the cure rate of the psoriasis is as high as 90.5%, no relapse occurs after the composition is used; in addition, the preparation and the use of the traditional Chinese medicine composition are also comparatively simple and convenient, thus the traditional Chinese medicine composition is worthy of popularizing and applying clinically.

Description

Psoriasic Chinese medicine composition of a kind of treatment and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to psoriasic Chinese medicine composition of a kind of treatment and preparation method thereof.

Background technology

" psoriasis " belongs to commonly encountered diseases, frequently-occurring disease in China.Psoriasic skin lesion form is varied, the distribution position is very extensive, state of an illness weight difference is also very big, can be divided into four types: 1, the homeliness type psoriasis: erythra generally occurs in scalp, trunk, extremity are stretched side, be to occur red pimple on skin, flaring is fused into patch or speckle greatly, and there are thicker silvery white phosphorus bits on the surface, out-of-shape, what have has map or an island sample outward appearance, and the skin lesion that has is less, and is more, be the Caulis et folium pavettae hongkongensis outward appearance, squama layer one deck comes off, and wipes scurf gently off and can see the red film of very thin one deck, strikes off red film and can see slight petechia, there is person to reveal, medically makes the sieve shape hemorrhage again for blood; 2, erythrodermic psoriasis: be more serious, more rare is a kind of, this kind of is meant and is the diffusivity redness more than 70% at about whole skin, kermesinus wellability skin lesion, surface have a large amount of bran skin sample scurfs, sometimes in the oxter, thigh root and umbilical part make exfoliation because of swelling and ooze out, oropharynx nose and eye conjunctiva can be congested rubescent, and the patient often has heating fear of cold, symptoms such as headache and general malaise; 3, pustule type psoriasis: divide general property and limitation, general property pustule type psoriasis mostly is acute onset, can be in a few days to several weeks general whole body of pustule, the intensive potential pimple of needle point size is arranged earlier, be fused into the pus lake very soon, often with hyperpyrexia, arthralgia and general malaise, routine blood test is chemically examined visible leukocytosis, after abscess is dry, and desquamation immediately, after scurf comes off, there is new abscess to occur again; Limitation pustule type psoriasis is seen with palm toe pustule type psoriasis more, at the both hands palms and toes portion the symmetry erythema is arranged, occur syringe needle on the erythema and arrive Li Daxiao greatly to pimple: about 1-2 dries up after week voluntarily, and new pustule appearance is arranged again behind the desquamation, be continuous course of disease stubbornness repeatedly; 4, psoriasis arthropathica: rarely found, any age all can take place, can betide big or small joint simultaneously, but common is wrist, finger and the little joint of toes, joint of vertebral column also can take place; there is redness in the joint of pathological changes; pain; serious articular cavity has hydrops; juxtra-articular skin turgor limitation of activity; joint stiffness of a specified duration, the ruined situation in visible joint under X line when serious, and erythrocyte sedimentation rate is fast; General Symptomies such as the heat that often occurs together; but rheumatoid agglutinating factor is negative, psoriasis arthropathica; and skin lesion is many with the ostraceous skin lesion of thick picture, and the skin lesion of psoriasic erythema of homeliness type and silver bits also can only be arranged.

Show that according to the interrelated data statistics China has nearly 8,000 ten thousand people of " psoriasis " patient at present, mostly occur that World Health Organization (WHO) lists one of the world's ten big pertinacious diseases to " psoriasis " in China the north and west area.Have a strong impact on numerous patients' physical and mental health, how to allow the psoriatic break away from the puzzlement of the serious illness, make the thorough rehabilitation of patient, be the problem that world medical circle is paid close attention to always.But the Chinese medicine that emerges in an endless stream at present, Western medicine, curative effect is unsatisfactory, can not change the vicious cycle of " medication improvement "-" clinical cure "-" recurrence exceeds the time limit " all the time.

Summary of the invention

The object of the present invention is to provide the psoriasic Chinese medicine composition of a kind of treatment, utilize said composition treatment psoriasis short treating period, determined curative effect, with after do not recur.

The technical solution used in the present invention is as follows:

The psoriasic Chinese medicine composition of a kind of treatment is made by each crude drug of following portions by weight: 30～50 parts of Radix Rumicis Crispi, 15～30 parts of Cortex Pseudolariciss, 6～15 parts of Semen Hydnocarpi, 6～15 parts of Scolopendras, 3～15 parts of Mylabris, 0.3～1 part of Calomelas, 10～30 parts of calcined Alumen, 10～15 parts in Pericarpium Zanthoxyli, 15～50 parts of Radix Sophorae Flavescentiss, 15～30 parts of Folium Artemisiae Argyis, 15～30 parts of Fructus Cnidiis, 15～30 parts of Cortex erythrinaes, 15～30 parts of Cortex Dictamni.

Preferably, the parts by weight of described each crude drug are: 30 parts of Radix Rumicis Crispi, 30 parts of Cortex Pseudolariciss, 15 parts of Semen Hydnocarpi, 6 parts of Scolopendras, 3 parts of Mylabris, 0.3 part of Calomelas, 10 parts of calcined Alumen, 10 parts in Pericarpium Zanthoxyli, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Folium Artemisiae Argyis, 15 parts of Fructus Cnidiis, 15 parts of Cortex erythrinaes, 15 parts of Cortex Dictamni.

The present invention also aims to provide the preparation method of the psoriasic Chinese medicine composition of a kind of described treatment: by weight/the volume ratio meter, take by weighing Radix Rumicis Crispi 30～50g, Cortex Pseudolaricis 15～30g, Semen Hydnocarpi 6～15g, Scolopendra 6～15g, Mylabris 3～15g, Calomelas 0.3～1g, calcined Alumen 10～30g, Pericarpium Zanthoxyli 10～15g, Radix Sophorae Flavescentis 15～50g, Folium Artemisiae Argyi 15～30g, Fructus Cnidii 15～30g, Cortex erythrinae 15～30g, Cortex Dictamni 15～30g, medical alcohol 500～1000ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor raw material of Chinese medicine medicines are ground to the powder altogether, add medical alcohol, soak after 2～7 days, get its soak and get lotion.Because each crude drug back that grinds to the powder is altogether soaked and to be got its soak and use, so, the granularity of smalls is not done requirement.Described medical alcohol is that the ethanol volume fraction (concentration) on the ordinary meaning is 70%～75% ethanol.

Preferably, the consumption of described 13 flavor raw material of Chinese medicine medicines is: Radix Rumicis Crispi 30g, Cortex Pseudolaricis 30g, Semen Hydnocarpi 15g, Scolopendra 6g, Mylabris 3g, Calomelas 0.3g, calcined Alumen 10g, Pericarpium Zanthoxyli 10g, Radix Sophorae Flavescentis 15g, Folium Artemisiae Argyi 15g, Fructus Cnidii 15g, Cortex erythrinae 15g, Cortex Dictamni 15g.

To be the inventor get in conjunction with motherland's Chinese medicine marrow dialectical prescription according to oneself clinical experience for many years in the present invention, dialectical for the heat in blood wind-dryness, with the passing of time impairment of YIN, heat remain into due to the poison, controls suitable heat-clearing and toxic substances removing, removing heat from blood is nourshing Yin and drynsessmoistening prescription.In the crude drug, Radix Rumicis Crispi, spleen, stomach, liver, large intestine, urinary bladder channel are returned in bitter, acid, cold, and heat-clearing and toxic substances removing, parasite killing are controlled tinea, relieving constipation; Cortex Pseudolaricis, the another name Cortex Pseudolaricis, hot, temperature, poisonous is returned lung, spleen channel, and killing parasites for relieving itching cures mainly various tinea such as tinea corporis, tinea manus and pedis, tinea capitis; Semen Hydnocarpi, another name Semen Hydnocarpi core, hot, heat, poisonous is gone into the liver,spleen,kidney warp, dispeiling pathogenic wind and removing dampness, detoxicating and killing parasites; Scolopendra, hot, flat, poisonous, return Liver Channel, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Mylabris, nature and flavor, suffering, heat, very toxic, removing blood stasis disappears and gargles, dispersing pathogen accumulation; Calomelas, hot, cold, poisonous, return liver, kidney channel, parasite killing, counteracting toxic substances, control scabies; Forge Bai Fan, be commonly called as dried Alumen, sour, puckery, poisonous, go into lung, spleen, stomach, large intestine channel, dampness, detoxifcation, parasite killing; Pericarpium Zanthoxyli, warm in nature, acrid in the mouth is included into spleen, stomach, kidney channel, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifcation, removing dampness and killing parasites; Radix Sophorae Flavescentis, bitter, cold, go into liver, kidney, large intestine, small intestine meridian, heat clearing away, dampness, parasite killing; Folium Artemisiae Argyi, warm in nature, bitter in the mouth, suffering are gone into spleen, liver, kidney channel, warming the meridian for stopping bleeding, dispersing cold for relieving pain, removing dampness to relieve itching; Fructus Cnidii, hot, warm, go into kidney, spleen channel, dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching; Cortex erythrinae, i.e. Cortex Zanthoxyli ailanthoidis, toil, flat is gone into liver, spleen channel, wind-damp dispelling, the meridian dredging, parasite killing; Cortex Dictamni, bitter salty, cold, go into spleen, stomach warp, dispeiling pathogenic wind and removing dampness, heat-clearing and toxic substances removing.More than all medicines play the effect that detoxicating and killing parasites, removing dampness are held back skin ulcer, dampness removing to stop itchin, removing blood stasis eliminating stagnation, expelling wind and cold, relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain altogether.

Using method: the lotion that the present invention is made evenly is applied in the affected part, 3 times on the one, can fully recover in 2～3 months.

Taboo: inlet, eye.

Chinese medicine composition of the present invention has the effect that detoxicating and killing parasites, removing dampness are held back skin ulcer, dampness removing to stop itchin, removing blood stasis eliminating stagnation, expelling wind and cold, relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, to psoriasic four types of advantages that all present short treating period, determined curative effect, to psoriasic cure rate up to 90.5%, with after do not recur, and its preparation and use also quite easyly, be worth applying clinically.

The specific embodiment

Below with specific embodiment the present invention is described in further detail, but protection scope of the present invention is not limited thereto:

Embodiment 1

Take by weighing Radix Rumicis Crispi 30g, Cortex Pseudolaricis 30g, Semen Hydnocarpi 15g, Scolopendra 6g, Mylabris 3g, Calomelas 0.3g, calcined Alumen 10g, Pericarpium Zanthoxyli 10g, Radix Sophorae Flavescentis 15g, Folium Artemisiae Argyi 15g, Fructus Cnidii 15g, Cortex erythrinae 15g, Cortex Dictamni 15g, medical alcohol 500ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor crude drug are ground to the powder altogether, add medical alcohol, soak after 2 days, get its soak and get lotion.

Embodiment 2

Take by weighing Radix Rumicis Crispi 50g, Cortex Pseudolaricis 15g, Semen Hydnocarpi 6g, Scolopendra 15g, Mylabris 15g, Calomelas 1g, calcined Alumen 30g, Pericarpium Zanthoxyli 15g, Radix Sophorae Flavescentis 50g, Folium Artemisiae Argyi 30g, Fructus Cnidii 30g, Cortex erythrinae 30g, Cortex Dictamni 30g, medical alcohol 1000ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor crude drug are ground to the powder altogether, add medical alcohol, soak after 7 days, get its soak and get lotion.

Embodiment 3

Take by weighing Radix Rumicis Crispi 35g, Cortex Pseudolaricis 25g, Semen Hydnocarpi 12g, Scolopendra 9g, Mylabris 7g, Calomelas 0.5g, calcined Alumen 15g, Pericarpium Zanthoxyli 12g, Radix Sophorae Flavescentis 25g, Folium Artemisiae Argyi 20g, Fructus Cnidii 20g, Cortex erythrinae 20g, Cortex Dictamni 20g, medical alcohol 630ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor crude drug are ground to the powder altogether, add medical alcohol, soak after 4 days, get its soak and get lotion.

Embodiment 4

Take by weighing Radix Rumicis Crispi 40g, Cortex Pseudolaricis 20g, Semen Hydnocarpi 9g, Scolopendra 12g, Mylabris 11g, Calomelas 0.8g, calcined Alumen 20g, Pericarpium Zanthoxyli 14g, Radix Sophorae Flavescentis 35g, Folium Artemisiae Argyi 25g, Fructus Cnidii 25g, Cortex erythrinae 25g, Cortex Dictamni 25g, medical alcohol 750ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor crude drug are ground to the powder altogether, add medical alcohol, soak after 5 days, get its soak and get lotion.

Clinical trial:

(1), physical data: accept patient's 63 examples altogether for medical treatment, male 30 examples, women 33 examples, 6～60 years old age, the course of disease 60 days～12 years; Homeliness type 34 examples wherein, erythrodermic 12 examples, pustule type 10 examples, joint type 7 examples.

(2), efficacy assessment standard: recovery from illness: skin lesion symptoms such as red pimple and speckle, squamous silver bits, shinny thin film, petechial hemorrhage, pustule all disappear, the arthropathy of getting involved, pain disappearance, activity freely, other conscious Signs all disappears; Produce effects: skin lesion symptoms such as red pimple, squamous silver bits, shinny thin film, petechial hemorrhage, pustule etc. obviously disappear more than 70%, and the arthropathy of getting involved returns to normally substantially, and pain obviously alleviates, and mobility significantly strengthens, and other conscious Signs obviously disappears; Take a turn for the better: skin lesion resolution of symptoms such as red pimple, silver bits, shinny thin film, petechial hemorrhage, pustule are more than 50%, and the arthropathy of getting involved, pain alleviate to some extent, can do the activity of bending and stretching by a small margin, and other conscious Signs alleviates to some extent; Invalid: skin lesion symptoms such as red pimple, silver bits, shinny thin film, petechial hemorrhage, pustule do not have and obviously disappear, the arthropathy of getting involved, pain no change, and activity is still limited, other conscious Signs no change.

(3), administering mode and approach: with lotion administration of the present invention, evenly be applied in the affected part, 3 times on the one.

(4), statistical result:

Model case

Case 1 Zhang, man, 18 years old.Readme before 3 years extremity, trunk play tinea, the white squama that comes off, the red pruritus of color spreads all over whole body gradually.Diagnosis: homeliness type psoriasis.External embodiment 1 liquid medicine was treated after 2 months, and the whole body skin lesion disappears, skin smooth, and not recurrence is followed up a case by regular visits to so far in recovery from illness.

Case 2 Lee, woman, 40 years old.Before the readme 5 years, originally unknown cause has only scalp and elbow joint position proriasiform skin lesion to occur, since nearest 1 year, the symptom of pain appears in elbow joint, once the multi-treatment poor effect, the arthralgia phenomenon has the development trend that grows in intensity, joint stuffiness, end bowl are held the so usual again life activity only of thing and are all felt unable sometimes deeply, helplessly, turn to any doctor one can find when critically ill, have the attitude of trying in arms and come the inventor to locate to seek to wish.After diagnosing, be diagnosed as " arthrosis type psoriasis ", the liquid medicine of external embodiment 2, after 20 days, the skin lesion symptom comes off gradually, and arthralgia also makes moderate progress, and can do some flexors by a small margin, continue medication again after 30 days, the skin lesion position returns to the normal colour of skin substantially fully, and the arthralgia symptom disappears, and activity freely, the back is followed up a case by regular visits to and is not seen recurrence so far with consolidating three weeks of medication.

Case 3 Zhao so-and-so, man, 35 years old.Before the readme 7 years, originally a small amount of erythra appears in whole body, and over nearly 2 years, erythra increases gradually, and existing whole body is general sends out red rash large stretch of, covers white squama, and serious pruritus is once in how tame hospitalize, poor effect.After come the inventor to locate to go to a doctor upon somebody's introduction, be diagnosed as " Folium Styracis Suberifoliae type psoriasis ", the liquid medicine of external embodiment 3 is treated after 15 days, squama reduces gradually, pruritus also alleviates to some extent, and mistake is after 10 days again, and erythra reduces, damaged skin begins to recover, squama disappears, and just also has pruritus once in a while, continues medication again 20 days, erythra presents point-like, damaged skin is most of to be repaired, and no pruritus is again excessively after 15 days, erythra is disappeared, other self-induction Signs has disappeared completely, and family numbers of patients is indebted forever, follows up a case by regular visits to and does not see recurrence so far.

Case 4 Yangs, woman, 53 years old.The readme skin lesion is just sent out on the basis of acute inflammation erythema, most intensive syringe needles occur to the shallow pustule of foxtail millet grain size aseptic table, with a small amount of thin thin squama.In this year, pustule increases rapidly, is fused into large stretch of pus pasty state mutually.Be diagnosed as " pustule type psoriasis ", the liquid medicine of external embodiment 4 is after one month, and pustule begins incrustation, most of squama comes off, and continues the medication one and a half months, and the speckle of incrustation and squama come off ground without a trace, skin recovers normal color, follows up a case by regular visits to and does not see recurrence so far.

Claims

1. the psoriasic external medicine composition of treatment is characterized in that being made by each crude drug of following portions by weight: 30～50 parts of Radix Rumicis Crispi, 15～30 parts of Cortex Pseudolariciss, 6～15 parts of Semen Hydnocarpi, 6～15 parts of Scolopendras, 3～15 parts of Mylabris, 0.3～1 part of Calomelas, 10～30 parts of calcined Alumen, 10～15 parts in Pericarpium Zanthoxyli, 15～50 parts of Radix Sophorae Flavescentiss, 15～30 parts of Folium Artemisiae Argyis, 15～30 parts of Fructus Cnidiis, 15～30 parts of Cortex erythrinaes, 15～30 parts of Cortex Dictamni.

2. the psoriasic external medicine composition of treatment as claimed in claim 1, it is characterized in that: the parts by weight of described each crude drug are: 30 parts of Radix Rumicis Crispi, 30 parts of Cortex Pseudolariciss, 15 parts of Semen Hydnocarpi, 6 parts of Scolopendras, 3 parts of Mylabris, 0.3 part of Calomelas, 10 parts of calcined Alumen, 10 parts in Pericarpium Zanthoxyli, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Folium Artemisiae Argyis, 15 parts of Fructus Cnidiis, 15 parts of Cortex erythrinaes, 15 parts of Cortex Dictamni.

One kind the treatment psoriasic Chinese medicine composition preparation method, it is characterized in that: by weight/the volume ratio meter, take by weighing Radix Rumicis Crispi 30～50g, Cortex Pseudolaricis 15～30g, Semen Hydnocarpi 6～15g, Scolopendra 6～15g, Mylabris 3～15g, Calomelas 0.3～1g, calcined Alumen 10～30g, Pericarpium Zanthoxyli 10～15g, Radix Sophorae Flavescentis 15～50g, Folium Artemisiae Argyi 15～30g, Fructus Cnidii 15～30g, Cortex erythrinae 15～30g, Cortex Dictamni 15～30g, medical alcohol 500～1000ml, standby; Radix Rumicis Crispi, Cortex Pseudolaricis, Semen Hydnocarpi, Scolopendra, Mylabris, Calomelas, calcined Alumen, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Fructus Cnidii, Cortex erythrinae and Cortex Dictamni 13 flavor raw material of Chinese medicine medicines are ground to the powder altogether, add medical alcohol, soak after 2～7 days, get its soak and get lotion.

4. the preparation method of the psoriasic Chinese medicine composition of treatment as claimed in claim 3 is characterized in that the consumption of described 13 flavor raw material of Chinese medicine medicines is: Radix Rumicis Crispi 30g, Cortex Pseudolaricis 30g, Semen Hydnocarpi 15g, Scolopendra 6g, Mylabris 3g, Calomelas 0.3g, calcined Alumen 10g, Pericarpium Zanthoxyli 10g, Radix Sophorae Flavescentis 15g, Folium Artemisiae Argyi 15g, Fructus Cnidii 15g, Cortex erythrinae 15g, Cortex Dictamni 15g.