CN101618155B - Medicine for curing oral mucosal disease - Google Patents

Medicine for curing oral mucosal disease Download PDF

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CN101618155B
CN101618155B CN2009100656522A CN200910065652A CN101618155B CN 101618155 B CN101618155 B CN 101618155B CN 2009100656522 A CN2009100656522 A CN 2009100656522A CN 200910065652 A CN200910065652 A CN 200910065652A CN 101618155 B CN101618155 B CN 101618155B
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radix
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herba
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CN101618155A (en
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辛保山
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Abstract

The invention provides a medicine for curing an oral mucosal disease. The medicine is prepared by the following raw traditional Chinese medical materials: mint, mulberry leaves, chrysanthemums, roots of straight ladybell, radix scrophulariae, ophiopogon roots, radix rehmanniae recen, angelica, rhizoma anemarrhenae, fiveleaf akebia, lophatherum gracile, atractylodes, Tuckahoe, honeysuckle flowers, scutellaria, trichosanthes roots, gardenia, balloon flowers and liquorice. All components in the invention are used to jointly take the efficacy of nourishing Yin, reducing fever, clearing lung and stomach, dispelling wind, reducing pathogenic fire and enriching the blood to restore normal menstruation. The invention differentially cures the vulvar leukoplakia by traditional Chinese medical science, has ideal curing effect and achieves a curative ratio up to 85 percent so that patients can be cured for 6-10 days.

Description

A kind of medicine for the treatment of diseases of oral mucosa
Technical field
The invention belongs to technical field of pharmaceuticals, relate to a kind of medicine for the treatment of diseases of oral mucosa.
Background technology
Diseases of oral mucosa is a kind of common mucosal disease, and common have recurrent oral ulceration, angular cheilitis, a cheilitis etc.Diseases of oral mucosa seems minor illness, but the oral cavity connects internal organs, correlates whole body, can promptly and accurately reflect the pathological changes of whole body each several part, thoroughly treatment can not cause it to show effect repeatedly, increase the weight of year by year, touching difficulty heals, and the oral mucosa large tracts of land is festered, can bring disaster to throat even the intestines and stomach, that have even hyperpyrexia occurs, threat to life, but only a few patient canceration.
Wherein the marked feature of oral ulcer is to show effect repeatedly, the ulcer number from less to more, the position from front to back, be mainly in oral mucosa, gingiva, tongue body up and down with side and bottleneck throat, the face that festers is big as Semen Glycines, and is little of the grain of rice, the surface attachment adularescent rotten film that festers.But the lighter's several months takes place once, and weight person shortens the intermission gradually, increase the weight of year by year, even rise one after another several years, many decades of ulcer does not heal.Angular cheilitis is commonly called as mashed mouth, be more common in school age's child, particularly infectious stomatitis can cause popular, mostly be chronic, symmetry, the course of disease can reach several weeks or several months, main performance is that the both sides bicker all is canescence, is feature with Mucocutaneous laterally the chapping of bicker, and the sepage in the district that chaps can be formed thin and acarpous lurid crust.Cheilitis is the general name that betides the diseases associated with inflammation of lip, cheilitis be a kind of with xerocheilia, chap, desquamation is the mucosal disease of main clinical manifestation, specifically can be divided into polytype.
Chinese medical discrimination is thought the many because retention of heat in the spleen and stomach of diseases of oral mucosa, hot dry fire-transformation, on smoke in lip, the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, follow through on attack, the smoked oral mucosa that burns forms ulcer.Asthenic fire person is many because of hyperactivity of fire caused by deficiency of YIN, goes up scorching oral cavity, the sarolemma of burning, or by stagnation of dampness due to deficiency of the spleen, dysfunction of the spleen in transportation causes the spleen sun not rise, turbid YIN failing to descend, and strongly fragrant removing dampness of a specified duration, upward smoked oral cavity causes ulcer.At the above cause of disease, control suitable nourishing YIN and clearing away heat, function of spleen and stomach regulating, dispelling wind pathogens, blood enriching and dryness moistening.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of effective treatment diseases of oral mucosa.
For achieving the above object, the present invention is by the following technical solutions: a kind of medicine for the treatment of diseases of oral mucosa, make by following parts by weight of traditional Chinese medicines raw material: 9~15 parts of Herba Menthaes, 9~15 parts on Folium Mori, 9~15 parts of Flos Chrysanthemis, 9~15 parts of Radix Adenophorae (Radix Glehniae), 9~15 parts of Radix Scrophulariaes, 9~15 parts of Radix Ophiopogonis, 9~15 parts of Radix Rehmanniae, 9~15 parts of Radix Angelicae Sinensis, 9~15 parts of the Rhizoma Anemarrhenaes, 9~15 parts of Caulis Akebiaes, 9~15 parts of Herba Lophatheris, 9~15 parts of the Rhizoma Atractylodis Macrocephalaes, 9~15 parts in Poria, 9~15 parts of Flos Loniceraes, 9~15 parts of Radix Scutellariaes, 9~15 parts of Radix Trichosanthis, 9~15 parts of Fructus Gardeniaes, 9~15 parts in 9~15 parts of Radix Platycodoniss and Radix Glycyrrhizae.
The parts by weight of described each raw material of Chinese medicine are: 12 parts in 12 parts of Herba Menthaes, 12 parts on Folium Mori, 12 parts of Flos Chrysanthemis, 12 parts of Radix Adenophorae (Radix Glehniae), 12 parts of Radix Scrophulariaes, 12 parts of Radix Ophiopogonis, 12 parts of Radix Rehmanniae, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Anemarrhenaes, 12 parts of Caulis Akebiaes, 12 parts of Herba Lophatheris, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 12 parts of Flos Loniceraes, 12 parts of Radix Scutellariaes, 12 parts of Radix Trichosanthis, 12 parts of Fructus Gardeniaes, 12 parts of Radix Platycodoniss and Radix Glycyrrhizae.
Described medicine is a decoction, during preparation each raw material is mixed, and adds raw material gross weight 5-7 decocting doubly then and boils 20-30 minute, the extracting juice that removes slag, one pair of every day, twice sooner or later.
Raw material of the present invention also can be made pill, tablet or capsule according to a conventional method.
Among the present invention, Herba Menthae, acrid in the mouth, cool in nature, go into lung, Liver Channel, dispelling wind is arranged, heat radiation is warded off dirtyly, and the effect of detoxifcation is controlled affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, the dyspepsia flatulence, aphtha is had a toothache skin ulcer scabies, urticaria.Folium Mori, bitter in the mouth, sweet, cold in nature, go into lung, Liver Channel, expelling wind and clearing away heat is arranged, the cooling blood for improving eyesight effect is controlled the pathogenic wind-warm heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Flos Chrysanthemi, sweet in the mouth, hardship, cool in nature, go into lung, Liver Channel, dispelling wind is arranged, heat clearing away makes eye bright, and the effect of detoxifcation is controlled headache, and is dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Radix Adenophorae (Radix Glehniae), bitter in the mouth is slightly cold, and is nontoxic, clearing lung and nourishing yin.Radix Scrophulariae, bitter in the mouth, salty, cool in nature, go into lung, kidney channel, YIN nourishing is arranged, pathogenic fire reducing, relieving restlessness, detoxicating functions is controlled consumption of YIN caused by febrile disease, and tongue is unraveled silk excessive thirst, sends out speckle, the hectic fever due to YIN-deficiency consumptive fever, and it is not peaceful to sleep night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula, maculae caused by violent heat pathogen, conjunctival congestion, diphtheria, sore.Radix Ophiopogonis, sweet in the mouth, little hardship is slightly cold, and GUIXIN, lung, stomach warp have YIN nourishing and the production of body fluid promoting, and the lung moistening effect that clears away heart-fire is used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Radix Rehmanniae, sweet in the mouth, hardship, cold in nature, go into the heart, liver, kidney channel, heat clearing away is arranged, removing heat from blood, the effect of YIN nourishing and the production of body fluid promoting is used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and sends out the speckle dermexanthesis.Radix Angelicae Sinensis, sweet in the mouth, suffering, warm in nature, go into the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving is moisturized the laxation effect, controls menoxenia, and amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; The dryness of the intestine dyschezia is heavy after the bloody dysentery; The carbuncle skin ulcer is stolen, injury from falling down.The Rhizoma Anemarrhenae, bitter in the mouth, cold in nature, go into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the laxation effect, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Caulis Akebiae, bitter in the mouth, cool in nature, go into the heart, small intestinal, urinary bladder channel, pathogenic fire purging row water is arranged, the promoting blood circulation effect is controlled hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Herba Lophatheri, sweet in the mouth, light, cold in nature, GUIXIN, stomach, small intestine meridian, clearing heat and relieving fidgetness, diuresis is used for the calentura excessive thirst, and hot urination drenches pain, aphtha of the mouth and tongue.The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature, go into spleen, stomach warp, spleen reinforcing is arranged, stomach reinforcing, dampness and in, antiabortive effect is controlled deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension is had loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.Poria, sweet in the mouth, light, property is flat, goes into the heart, spleen, lung meridian, eliminating dampness and diuresis, the strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming is controlled dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Flos Lonicerae, sweet in the mouth, cold in nature, go into lung, stomach warp, heat clearing away is arranged, detoxicating functions is controlled the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Radix Scutellariae, bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, large intestine channel, the removing the relative excess fire, except that damp and hot, hemostasis, antiabortive, control the high fever excessive thirst, the cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria is told, is defeated in battle, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.Radix Trichosanthis, sweet in the mouth, hardship, acid, cool in nature, go into lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing is moisturized, evacuation of pus, the detumescence effect, it is thirsty to control calentura, quenches one's thirst jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Fructus Gardeniae, bitter in the mouth, cold in nature, go into the heart, liver, lung, stomach warp, heat clearing away is arranged, pathogenic fire purging, the removing heat from blood effect is controlled the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.Radix Platycodonis, bitter in the mouth, suffering, property is flat, goes into lung, stomach warp, and lung qi dispersing gas is arranged out, and the evacuation of pus effect of eliminating the phlegm is controlled the exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Radix Glycyrrhizae, sweet in the mouth, property is flat, goes into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the coordinating the actions of various ingredients in a prescription effect is controlled laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.
It is main effect that the present invention selects Herba Menthae, Folium Mori, Flos Chrysanthemi, Flos Lonicerae, Radix Scutellariae wind and heat dispersing and Radix Adenophorae (Radix Glehniae), Radix Scrophulariae, Radix Ophiopogonis, Radix Rehmanniae, the Rhizoma Anemarrhenae, Herba Lophatheri, Caulis Akebiae, Fructus Gardeniae nourishing YIN to lower pathogenic fire for use, be aided with the Rhizoma Atractylodis Macrocephalae, Poria, Radix Platycodonis conditioning lung stomach, Chinese angelica blood supplementing is moisturized, the Radix Trichosanthis pathogenic fire reducing is moisturized, Radix Glycyrrhizae lung moistening, coordinating the actions of various ingredients in a prescription, each component is share among the present invention, play the effect of nourishing YIN and clearing away heat, cleaning lung stomach, dispelling wind pathogenic fire reducing, blood enriching and dryness moistening altogether, the tcm syndrome differentiation and treatment diseases of oral mucosa, the therapeutic effect ideal, cure rate can be cured up to more than 85% in general 6-10 days.
Through clinical treatment statistics, adopting Drug therapy of the present invention to suffer from recurrent oral ulceration has 750 examples, has 680 routine patients thoroughly to cure, and still has the recurrence sign after 70 routine patients cure in addition, and the cure rate of recurrent oral ulceration is reached 91%; Treatment cheilitis 450 examples have 385 routine patients thoroughly to cure, and 65 patients use effectively in addition, but recurrence, cure rate reaches 85%; Treatment angular cheilitis 520 examples have 450 routine patients to cure, and 70 routine patients use effectively in addition, but recurrence, cure rate reaches 86.5%.Effective percentage all reaches 100%.
The specific embodiment
Embodiment 1: Herba Menthae 9g, Folium Mori 9g, Flos Chrysanthemi 9g, Radix Adenophorae (Radix Glehniae) 9g, Radix Scrophulariae 9g, Radix Ophiopogonis 9g, Radix Rehmanniae 9g, Radix Angelicae Sinensis 9g, Rhizoma Anemarrhenae 9g, Caulis Akebiae 9g, Herba Lophatheri 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, Flos Lonicerae 9g, Radix Scutellariae 9g, Radix Trichosanthis 9g, Fructus Gardeniae 9g, Radix Platycodonis 9g and Radix Glycyrrhizae 9g.
During the preparation decoction each raw material is mixed, the decocting that adds 6 times of raw material gross weights then boiled 25 minutes, the extracting juice that removes slag, one pair of every day, twice on the one.
Embodiment 2: 12 parts in 12 parts of Herba Menthaes, 12 parts on Folium Mori, 12 parts of Flos Chrysanthemis, 12 parts of Radix Adenophorae (Radix Glehniae), 12 parts of Radix Scrophulariaes, 12 parts of Radix Ophiopogonis, 12 parts of Radix Rehmanniae, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Anemarrhenaes, 12 parts of Caulis Akebiaes, 12 parts of Herba Lophatheris, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 12 parts of Flos Loniceraes, 12 parts of Radix Scutellariaes, 12 parts of Radix Trichosanthis, 12 parts of Fructus Gardeniaes, 12 parts of Radix Platycodoniss and Radix Glycyrrhizae.
Make pill: above each raw material of Chinese medicine can be pulverized during preparation, add refined honey then and make honeyed pill, every ball 6g takes one time 1~2 ball, 2-3 time on the one.
Embodiment 3: 15 parts in 15 parts of Herba Menthaes, 15 parts on Folium Mori, 15 parts of Flos Chrysanthemis, 15 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Radix Scrophulariaes, 15 parts of Radix Ophiopogonis, 15 parts of Radix Rehmanniae, 15 parts of Radix Angelicae Sinensis, 15 parts of the Rhizoma Anemarrhenaes, 15 parts of Caulis Akebiaes, 15 parts of Herba Lophatheris, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts in Poria, 15 parts of Flos Loniceraes, 15 parts of Radix Scutellariaes, 15 parts of Radix Trichosanthis, 15 parts of Fructus Gardeniaes, 15 parts of Radix Platycodoniss and Radix Glycyrrhizae.
Make capsule: with above each raw material of Chinese medicine pulverize, mixing, incapsulate and get final product, one time 2~4,2-3 time on the one.
Umber among the above embodiment is parts by weight.
Model case:
Case 1: Zhang, the man, 30 years old, suffer from recurrent oral ulceration have 5 years surplus, symptom is a white ulcer surface, under the tongue body in the oral cavity in, winds with narrow blush around the boundary clear, and slight causalgia is arranged, assassination swashs and increases the weight of, and shows effect repeatedly, controls for a long time and does not heal.The back uses the medicine of the embodiment of the invention 3 to treat, every day three times, each four, took continuously 6 days, transference cure, after continue to take and continued to strengthen in 2 days, thoroughly cure, through paying a return visit recurrence.
Case 2: Fan, woman, 38 years old, xerocheilia during prescription on individual diagnosis, chap, desquamation, be diagnosed as cheilitis, take the medicine of the embodiment of the invention 2 and treat, twice of every day, each 1 ball, take medicine drying 5 days the time, chap, the transference cure of desquamation, it is normal that skin recovers, and continued to take 2 days, thoroughly cure, after recurrence.
Case 3, Wang, man, 8 years old, both sides bicker canescence, outward appearance have laterally chapped, it is easily broken to chap, and is diagnosed as angular cheilitis, takes the medicine of the embodiment of the invention 1 and treats, one pair of every day, one day twice, remarkable improvement is arranged when taking 5 days, continued to take 2 days, it is normal that transference cure, bicker recover, after recurrence.

Claims (3)

1. medicine for the treatment of diseases of oral mucosa is characterized in that being made by following parts by weight of traditional Chinese medicines raw material: 9~15 parts in 9~15 parts of Herba Menthaes, 9~15 parts on Folium Mori, 9~15 parts of Flos Chrysanthemis, 9~15 parts of Radix Adenophorae (Radix Glehniae), 9~15 parts of Radix Scrophulariaes, 9~15 parts of Radix Ophiopogonis, 9~15 parts of Radix Rehmanniae, 9~15 parts of Radix Angelicae Sinensis, 9~15 parts of the Rhizoma Anemarrhenaes, 9~15 parts of Caulis Akebiaes, 9~15 parts of Herba Lophatheris, 9~15 parts of the Rhizoma Atractylodis Macrocephalaes, 9~15 parts in Poria, 9~15 parts of Flos Loniceraes, 9~15 parts of Radix Scutellariaes, 9~15 parts of Radix Trichosanthis, 9~15 parts of Fructus Gardeniaes, 9~15 parts of Radix Platycodoniss and Radix Glycyrrhizae.
2. the medicine of a treatment diseases of oral mucosa as claimed in claim 1, it is characterized in that: the parts by weight of described each raw material of Chinese medicine are: 12 parts in 12 parts of Herba Menthaes, 12 parts on Folium Mori, 12 parts of Flos Chrysanthemis, 12 parts of Radix Adenophorae (Radix Glehniae), 12 parts of Radix Scrophulariaes, 12 parts of Radix Ophiopogonis, 12 parts of Radix Rehmanniae, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Anemarrhenaes, 12 parts of Caulis Akebiaes, 12 parts of Herba Lophatheris, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 12 parts of Flos Loniceraes, 12 parts of Radix Scutellariaes, 12 parts of Radix Trichosanthis, 12 parts of Fructus Gardeniaes, 12 parts of Radix Platycodoniss and Radix Glycyrrhizae.
3. the medicine of a treatment diseases of oral mucosa as claimed in claim 1 or 2, it is characterized in that: described medicine is a decoction, during preparation each raw material is mixed, and adds raw material gross weight 5-7 decocting doubly then and boils 20-30 minute, extracting juice removes slag.
CN2009100656522A 2009-08-05 2009-08-05 Medicine for curing oral mucosal disease Expired - Fee Related CN101618155B (en)

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CN102370878B (en) * 2010-08-23 2013-04-03 祁银学 Chinese medicinal oral preparation for treating aphthous stomatitis
CN102389537A (en) * 2011-11-11 2012-03-28 哈尔滨市天地仁医药科技有限公司 Traditional Chinese medicine for treating oral cavity ulcer
CN103845633B (en) * 2012-12-03 2017-08-25 北京盈科瑞药物研究院有限公司 It is a kind of to treat Chinese medicine composition of canker sore and preparation method thereof
CN103071102A (en) * 2013-01-09 2013-05-01 李世柱 Traditional Chinese medicine for curing chronic cheilitis
CN103610874B (en) * 2013-11-22 2016-06-08 董刚 A kind of drinking water treating aphtha of the mouth and tongue
CN104127560A (en) * 2014-07-17 2014-11-05 陈筠 Traditional Chinese medicine composition for treating chronic cheilitis
CN104186862B (en) * 2014-09-15 2016-02-10 于福才 A kind of Chinese medicine tea-drinking for the treatment of canker sore and its production and use
CN104491825B (en) * 2015-01-11 2016-04-06 李子洪 A kind of Chinese medicine ointment for the treatment of oral ulcer
CN104758731B (en) * 2015-04-30 2018-06-19 安徽广和中药股份有限公司 A kind of Chinese medicine composition for treating corners of the mouth ulcer
CN105456708B (en) * 2015-12-30 2020-02-21 王睿超 Medicine for treating cheilitis and preparation method thereof
CN105709105A (en) * 2016-04-07 2016-06-29 四川省中医药科学院 Composition with function of clearing peculiar smell in oral cavity and preparation method of composition
JP7165977B2 (en) 2016-05-18 2022-11-07 日本ゼトック株式会社 toothpaste
CN107173763A (en) * 2017-06-13 2017-09-19 辽宁中医药大学 It is a kind of to treat Chinese herbal medicine jelly of recurrent oral ulceration and preparation method thereof
CN109364138A (en) * 2018-12-12 2019-02-22 马建国 A kind of medicine oil and preparation method thereof for treating bridou

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