CN101596224A - A kind of new purposes of penthorum chinense pursh extract - Google Patents
A kind of new purposes of penthorum chinense pursh extract Download PDFInfo
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- CN101596224A CN101596224A CNA2009100597543A CN200910059754A CN101596224A CN 101596224 A CN101596224 A CN 101596224A CN A2009100597543 A CNA2009100597543 A CN A2009100597543A CN 200910059754 A CN200910059754 A CN 200910059754A CN 101596224 A CN101596224 A CN 101596224A
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- penthorum chinense
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- chinense pursh
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Abstract
The invention provides a kind of new purposes of penthorum chinense pursh extract, described new purposes is meant and is used to prepare food, health food and the medicine that reduces the human body bilirubin level.The preparation method of penthorum chinense pursh extract is specially: A. gets Penthorum chinense 1000g, and chopping decocts with water three times, each 2 hours, collecting decoction filtered, filtrate is condensed into the clear paste that relative density is 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain alcohol amount and reach 60%; B. stir, leave standstill, filter, precipitation merges washing liquid and filtrate with 60% washing with alcohol three times, recovery ethanol and to be condensed into relative density be 1.30～1.32 thick paste, promptly.Concrete excipient mode was a liquid preparation when penthorum chinense pursh extract was used, solid particle, tablet, capsule and pill.
Description
Technical field
The invention belongs to food and medicine field, be specifically related to the new purposes of Penthorum chinense plant extract.
Background technology
Penthorum chinense has another name called Herba Lysimachiae Clethroids, Herba Penthori chinensis, delicacy from mountain pearl etc., and according to records such as " Tian Bao book on Chinese herbal medicine ", herbal for Relief of Famines, Penthorum chinense has effects such as collateral dredging is invigorated blood circulation, blood stasis dispelling dehumidifying, promoting blood circulation to remove blood stasis.
According to Chinese drug standard WS
3The disclosed GANSU KELI of-B-2526-97 is to be that feedstock production gets with the Penthorum chinense, and its preparation method is as follows: get Herba Lysimachiae Clethroids 1000g, chopping, decoct with water three times, each 2 hours, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain alcohol amount and reach 60%, stir, leave standstill, filter, precipitation is with 60% washing with alcohol three times, merge washing liquid and filtrate, reclaiming ethanol and being condensed into relative density is 1.30～1.32 thick paste, adds an amount of sucrose and starch, mixing, the system granule, drying is made 540g, promptly.Function cures mainly to falling enzyme, protects the liver jaundice eliminating, spleen invigorating.Be used for chronic active hepatitis, hepatitis B, also can be used for acute viral hepatitis, but do not see Penthorum chinense is used to reduce the bilirubinic relevant report of human body.
Bilirubin major part in the serum derives from the hemoglobin derivation that red blood cell aging generates after destroyed and forms, in liver, pass through the bilirubin direct that is called of glucuronidation, in liver through glucuronidation be called unconjugated bilirubin, the two and be exactly total bilirubin.Blood of human body mesobilirubin excessive concentration can cause position jaundice such as skin, mucosa.
(Chloasma Melasma) is also referred to as chloasma hepaticum to chloasma, is a kind of of facial melanosis, is the pigmentation spots that occurs in face, at present based on the Chinese medicine symptomatic treatment.The generation of chloasma is relevant with liver,spleen,kidney three dirty imbalances, and traditional Chinese medical science typing has caused by hepatic stagnation qi stagnation, controls suitable dispersing the stagnated live-QI to relieve the stagnation of QI, QI and blood regulating; The incoordination between the liver and spleen type is controlled suitable harmonizing the liver and spleen, dissipating phlegm and removing blood stasis; The deficiency of kidney-QI type is controlled suitable invigorating kidney for regulating menstruation, nourshing blood and promoting blood circulation; The not smooth type of blood stasis is controlled suitable blood circulation promoting and blood stasis dispelling, and circulation of qi promoting is soothing the liver.
Summary of the invention
Technical problem solved by the invention provides the new purposes of penthorum chinense pursh extract.Particularly, be penthorum chinense pursh extract to be used for preparation reduce the bilirubinic food of human body, health food and medicine, wherein, this penthorum chinense pursh extract is to be got by following method preparation:
A, get Penthorum chinense 1000g, chopping decocts with water three times, and each 2 hours, collecting decoction filtered, and filtrate is condensed into the clear paste that relative density is 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain the alcohol amount and reach 60%;
B, stirring are left standstill, and filter, and precipitation merges washing liquid and filtrate with 60% washing with alcohol three times, recovery ethanol and to be condensed into relative density be 1.30～1.32 thick paste, promptly.
Can further the described thick paste of step B be added acceptable accessories, can accept adjuvant and be meant starch, dextrin, lactose, sucrose, microcrystalline Cellulose, Pulvis Talci, polyvinylpolypyrrolidone, magnesium stearate, coating powder, ethanol, Mel, correctives.Be prepared into oral liquid, granule, tablet, capsule and pill according to conventional method.
The inventor irritates stomach by penthorum chinense pursh extract with 12.50g, 4.18g crude drug/kg and gives rat, respectively at getting hematometry bilirubin direct and total bilirubin level after the administration in 10,20,30 days.The result shows that penthorum chinense pursh extract has certain reduction effect to bilirubin level.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
Embodiment 1
Penthorum chinense pursh extract reduces the bilirubin pharmacodynamics test
1, summary
Penthorum chinense pursh extract is irritated stomach with 12.50g, 4.18g crude drug/kg and is given rat, respectively at getting hematometry bilirubin direct and total bilirubin level after the administration in 10,20,30 days.The result shows that penthorum chinense pursh extract has certain reduction effect to bilirubin level.
2, test objective
Observing penthorum chinense pursh extract irritates stomach for a long time and gives behind the rat influence to bilirubin level.
3, test material
3.1 be subjected to the reagent thing
Penthorum chinense pursh extract (extractum): dark-brown, matter thickness, 7.14g crude drug/ml.Think special medicine company limited by power lot number is provided: 080801.Face with preceding extractum is for experiment with the medicinal liquid that distilled water is mixed with 1.25g, 0.42g crude drug/ml.
The penthorum chinense pursh extract preparation method: get Herba Lysimachiae Clethroids 1000g, chopping decocts with water three times, each 2 hours, collecting decoction filtered, filtrate is condensed into the clear paste that relative density is 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain alcohol amount and reach 60%, stir, leave standstill, filter, precipitation is with 60% washing with alcohol three times, merge washing liquid and filtrate, reclaim ethanol and be condensed into the thick paste of relative density 1.30～1.32, promptly.
3.2 laboratory animal
The SD rat, body weight 180～220g, Chengdu University of Traditional Chinese Medicine's Experimental Animal Center provides, regular grade animal, animal credit number SCXK (river) 2008-11.
3.3 instrument
Roche automatic clinical chemistry analyzer INTEGRA 400plus Germany
T-1000 type electronic balance, d=0.1g, two outstanding brother's (group) company limiteies of the U.S..
3.4 feedstuff
Full price Mus pellet: provide by Sichuan Province's laboratory animal Professional Committee plant.
3.5 experimental condition
Breeding observing room temperature: 22～24 ℃.Relative humidity: 60%～70%.
4, method and result
54 of rats are divided into 3 groups (matched group and medicine high and low dose groups), 18 every group, male and female half and half at random by sex, body weight.Administration group rat gastric infusion every day once, dosage is respectively 12.50,4.18g crude drug/kg, irritating the stomach volume is 1.0ml/100g, successive administration 30 days.Matched group is irritated stomach isometric(al) distilled water with method.In the experimentation, weighed once in per 5 days, administration is in the time of the 10th, 20,30 days, each group is randomly drawed 6 rats (male and female half and half), get blood by eye socket, whole blood is put in 37 ℃ of waters bath with thermostatic control placed 1h, the centrifugal 10min of 2000r/min, separation of serum is measured bilirubin direct and total bilirubin with the Roche automatic clinical chemistry analyzer.The results are shown in Table.Each is organized data and all adopts mean ± standard deviation (x ± S) expression, group difference comparison, employing t check.
The table penthorum chinense pursh extract is to the influence of rat bilirubin level (x ± S)
It is as shown in the table, and penthorum chinense pursh extract is irritated stomach and given rat, and administration is in the time of the 10th day, and the bilirubin direct of high dose group animal decreases; Administration is in the time of the 20th day, and the bilirubin direct of high and low dose treated animal is compared reduction with total bilirubin with matched group; Administration is in the time of 30 days, and the total bilirubin of high and low dose treated animal is compared with matched group slightly and reduced.Aggregate analysis, Penthorum chinense is irritated stomach and is given rat, and its bilirubin level is compared matched group and is reduced.
5, conclusion
Penthorum chinense pursh extract respectively with 12.5,4.18g crude drug/kg irritates stomach and gives rat, continuous 30 days.Get hematometry bilirubin direct and total bilirubin in the time of the 10th, 20,30 days in administration, the result shows that penthorum chinense pursh extract has certain reduction effect to intact animal's bilirubin.
6, result and discussion
From above-mentioned result of the test as seen, penthorum chinense pursh extract has certain reduction effect to the bilirubin of normal rat, cure mainly analysis from the function of Penthorum chinense, it has the effect of treatment chloasma, therefore we think to have the clinical value for the treatment of chloasma by the penthorum chinense pursh extract reduction human body bilirubin level that adopts this patent preparation.
Embodiment 2 solid tablets
Get 1 part of penthorum chinense pursh extract, add appropriate amount of auxiliary materials, mixing, granulate dry, granulate, tabletting, promptly.And can be made into ordinary tablet, dispersible tablet, chewable tablet and effervescent tablet according to the difference of adding supplementary product kind.
Embodiment 3 solid particle agent
Get penthorum chinense pursh extract, add appropriate amount of auxiliary materials, mixing, it is dry to granulate, granulate, promptly.
Embodiment 4 solid gum wafers
Get penthorum chinense pursh extract, add appropriate amount of auxiliary materials, mixing breaks into the powder direct packaging behind granulate dry back packing or the extractum convection drying, promptly.
Embodiment 5 liquid oral liquid
Get penthorum chinense pursh extract, it is an amount of to add water, does not add or add adjuvants such as correctives, and filtration, degerming, fill are promptly.
Embodiment 6 solid pills
Get penthorum chinense pursh extract, convection drying is ground into fine powder or adds the appropriate amount of auxiliary materials crushed after being dried and becomes fine powder, adds finite concentration ethanol or the general one-tenth pill of hydromel promptly.
Claims (3)
1, a kind of new purposes of penthorum chinense pursh extract is characterized in that: described new purposes is meant and is used to prepare food, health food and the medicine that reduces the human body bilirubin level.The preparation method of penthorum chinense pursh extract: A, get Penthorum chinense 1000g, chopping decocts with water three times, and each 2 hours, collecting decoction filtered, and filtrate is condensed into the clear paste that relative density is 1.15～1.18 (60～65 ℃), and cooling adds ethanol and makes and contain the alcohol amount and reach 60%; B, stirring are left standstill, and filter, and precipitation merges washing liquid and filtrate with 60% washing with alcohol three times, recovery ethanol and to be condensed into relative density be 1.30～1.32 thick paste, promptly.
2, according to the new purposes of the described penthorum chinense pursh extract of claim 1, it is characterized in that: described new purposes is meant the new purposes that is used for preparing treatment human body chloasma medicine, is used for preparing the new purposes of the food and the health food that help reducing the human body bilirubin level.
3, new purposes according to claim 1 and 2 is characterized in that: the concrete excipient mode of described penthorum chinense pursh extract is: liquid preparation, solid particle, tablet, capsule or pill.
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| CNA2009100597543A CN101596224A (en) | 2009-06-25 | 2009-06-25 | A kind of new purposes of penthorum chinense pursh extract |
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| CNA2009100597543A CN101596224A (en) | 2009-06-25 | 2009-06-25 | A kind of new purposes of penthorum chinense pursh extract |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103242398A (en) * | 2013-04-26 | 2013-08-14 | 四川古蔺肝苏药业有限公司 | Dihydroflavone compound as well as preparation method and application for same |
| CN104013653A (en) * | 2014-06-18 | 2014-09-03 | 四川古蔺肝苏药业有限公司 | New use of penthorum chinense pursh or extract thereof |
| CN104431155A (en) * | 2014-11-19 | 2015-03-25 | 徐玉文 | Preparation method of penthorum chinense pursh tea soup |
| CN108245539A (en) * | 2018-04-13 | 2018-07-06 | 宇妥藏药股份有限公司 | A kind of preparation method of liver Soviet Union capsule |
| CN110051712A (en) * | 2019-04-24 | 2019-07-26 | 重庆大学 | A kind of penthorum chinense pursh is relieved the effect of alcohol the preparation method of effervescent tablet |
| CN113577124A (en) * | 2021-08-26 | 2021-11-02 | 四川子仁制药有限公司 | Penthorum chinense pursh tea paste manufacturing process |
-
2009
- 2009-06-25 CN CNA2009100597543A patent/CN101596224A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103242398A (en) * | 2013-04-26 | 2013-08-14 | 四川古蔺肝苏药业有限公司 | Dihydroflavone compound as well as preparation method and application for same |
| CN104013653A (en) * | 2014-06-18 | 2014-09-03 | 四川古蔺肝苏药业有限公司 | New use of penthorum chinense pursh or extract thereof |
| CN104431155A (en) * | 2014-11-19 | 2015-03-25 | 徐玉文 | Preparation method of penthorum chinense pursh tea soup |
| CN108245539A (en) * | 2018-04-13 | 2018-07-06 | 宇妥藏药股份有限公司 | A kind of preparation method of liver Soviet Union capsule |
| CN110051712A (en) * | 2019-04-24 | 2019-07-26 | 重庆大学 | A kind of penthorum chinense pursh is relieved the effect of alcohol the preparation method of effervescent tablet |
| CN113577124A (en) * | 2021-08-26 | 2021-11-02 | 四川子仁制药有限公司 | Penthorum chinense pursh tea paste manufacturing process |
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Open date: 20091209 |