CN101591412B - 氯霉素分子印迹聚合物微球的制备方法 - Google Patents
氯霉素分子印迹聚合物微球的制备方法 Download PDFInfo
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- CN101591412B CN101591412B CN2009100721663A CN200910072166A CN101591412B CN 101591412 B CN101591412 B CN 101591412B CN 2009100721663 A CN2009100721663 A CN 2009100721663A CN 200910072166 A CN200910072166 A CN 200910072166A CN 101591412 B CN101591412 B CN 101591412B
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- molecularly imprinted
- polymeric microspheres
- chloramphenicol
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- imprinted polymeric
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- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 title claims abstract description 60
- 229960005091 chloramphenicol Drugs 0.000 title claims abstract description 38
- 239000004005 microsphere Substances 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 28
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 15
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims abstract description 12
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims abstract description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000005406 washing Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 229940049547 paraxin Drugs 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 15
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 claims description 8
- ZCHPKWUIAASXPV-UHFFFAOYSA-N acetic acid;methanol Chemical compound OC.CC(O)=O ZCHPKWUIAASXPV-UHFFFAOYSA-N 0.000 claims description 6
- 239000003643 water by type Substances 0.000 claims description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- 238000006392 deoxygenation reaction Methods 0.000 claims description 4
- 235000011194 food seasoning agent Nutrition 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000006298 dechlorination reaction Methods 0.000 claims description 3
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 abstract description 7
- 229920000344 molecularly imprinted polymer Polymers 0.000 abstract description 5
- 238000005054 agglomeration Methods 0.000 abstract description 3
- 230000002776 aggregation Effects 0.000 abstract description 3
- 238000012662 bulk polymerization Methods 0.000 abstract description 3
- 230000001788 irregular Effects 0.000 abstract description 3
- 239000002244 precipitate Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- 238000005273 aeration Methods 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000010355 oscillation Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 238000009210 therapy by ultrasound Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 5
- 230000000274 adsorptive effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000012673 precipitation polymerization Methods 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000002594 sorbent Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002977 biomimetic material Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002222 matrix solid-phase dispersion Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- -1 perfluoro Chemical group 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004808 supercritical fluid chromatography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyamides (AREA)
Abstract
Description
聚合物 | 吸附量Q(μg/g) | 吸附率 (%) | 相对标准偏差 RSD(%) |
具体实施方式一所得氯霉素分 子印迹聚合物微球 | 5112 | 93.2~ 104 | 2.8 |
空白印迹聚合物微球 | 423 | 40~47 | 1.6 |
Claims (2)
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CN2009100721663A CN101591412B (zh) | 2009-06-03 | 2009-06-03 | 氯霉素分子印迹聚合物微球的制备方法 |
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CN2009100721663A CN101591412B (zh) | 2009-06-03 | 2009-06-03 | 氯霉素分子印迹聚合物微球的制备方法 |
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CN101591412A CN101591412A (zh) | 2009-12-02 |
CN101591412B true CN101591412B (zh) | 2011-05-18 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102336871B (zh) * | 2010-07-16 | 2013-11-06 | 中国科学院过程工程研究所 | 一种尺寸均一的氯霉素分子印迹聚合物微球及制备方法和应用 |
CN102875749A (zh) * | 2012-09-20 | 2013-01-16 | 宁波市疾病预防控制中心 | 一种氯霉素的氨基修饰磁性分子印迹聚合微球的制备方法 |
CN105111370B (zh) * | 2015-09-29 | 2017-12-19 | 徐州工程学院 | 一种氯霉素分子印迹聚合物及其制备方法 |
CN105218747B (zh) * | 2015-10-20 | 2017-08-22 | 大连理工大学 | 一种Poly(ACA‑co‑MAA‑co‑EDMA)微球的制备方法 |
CN106317325B (zh) * | 2016-09-14 | 2019-06-07 | 中国农业科学院农业质量标准与检测技术研究所 | ***类农药分子印迹聚合物微球,固相萃取柱及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1811409A (zh) * | 2006-02-16 | 2006-08-02 | 上海交通大学 | 氯霉素分子印迹固相萃取小柱的制备方法 |
CN1811411A (zh) * | 2006-02-16 | 2006-08-02 | 上海交通大学 | 氯霉素分子印迹聚合物微球的制备方法 |
WO2008007359A2 (en) * | 2006-07-09 | 2008-01-17 | Infigo Diagnostics Ltd. | Rapid diagnostic devices based on molecular imprinted polymers |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1811409A (zh) * | 2006-02-16 | 2006-08-02 | 上海交通大学 | 氯霉素分子印迹固相萃取小柱的制备方法 |
CN1811411A (zh) * | 2006-02-16 | 2006-08-02 | 上海交通大学 | 氯霉素分子印迹聚合物微球的制备方法 |
WO2008007359A2 (en) * | 2006-07-09 | 2008-01-17 | Infigo Diagnostics Ltd. | Rapid diagnostic devices based on molecular imprinted polymers |
Non-Patent Citations (3)
Title |
---|
王永向,刘冬梅,刘秋明,王琛毅,戎非,付德刚."氯霉素分子印迹聚合物的合成及其在固相萃取中的应用".《环境化学》.2008,第27卷(第3期),378-379. |
王永向,刘冬梅,刘秋明,王琛毅,戎非,付德刚."氯霉素分子印迹聚合物的合成及其在固相萃取中的应用".《环境化学》.2008,第27卷(第3期),378-379. * |
王荣艳,王培龙,王静,王锡昌,钟耀广."氯霉素分子印迹聚合物的合成及应用".<分析测试学报>.2008,第27卷(第9期),947-950. * |
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Effective date of registration: 20240628 Address after: 101200 No. 3, Ping three road, Pinggu District, Beijing Patentee after: BEIJING PURKINJE GENERAL INSTRUMENT Co.,Ltd. Country or region after: China Patentee after: Inner Mongolia General Instrument Co.,Ltd. Address before: 101200 No. 3, Ping three road, Pinggu District, Beijing Patentee before: BEIJING PURKINJE GENERAL INSTRUMENT Co.,Ltd. Country or region before: China |