CN101569523A - System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method - Google Patents
System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method Download PDFInfo
- Publication number
- CN101569523A CN101569523A CNA2009100503531A CN200910050353A CN101569523A CN 101569523 A CN101569523 A CN 101569523A CN A2009100503531 A CNA2009100503531 A CN A2009100503531A CN 200910050353 A CN200910050353 A CN 200910050353A CN 101569523 A CN101569523 A CN 101569523A
- Authority
- CN
- China
- Prior art keywords
- temperature
- laser
- grating
- real
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to a system for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and a data processing method. The system comprises a laser light source, an energy-transfer multimode fiber and a sensing fiber grating, wherein the light emitted by the laser light source is introduced into neoplastic tissues through the energy-transfer multimode fiber, a grid region of the sensing fiber grating is arranged in the neoplastic tissues, the light emitted by a broadband light source is connected to the sensing fiber grating through a fiber coupler, a reflectance spectrum is connected to an optical spectrometer through the fiber, and the optical spectrometer is connected to a computer terminal. Reflectance spectrum data is input to the computer terminal, and the distribution temperature of the treated neoplastic part is obtained through a core inversion algorithm. The system has the advantages of simple structure, easy manufacture, low cost, high precision and strong practicability, and provides a reliable plan for the real-time measurement of the tissue temperature in the course of treatment.
Description
Technical field:
The invention belongs to the crossing domain of Fibre Optical Sensor and laser medicine, districution temperature real-time measurement system and data processing method in particularly a kind of laser-induced interstitial thermotherapy, the districution temperature that is used for the treatment of laser irradiation tumor tissues zone in the process is measured in real time.
Background technology:
Laser-induced interstitial heating therapy (LITT, laser-induced interstitial thermotherapy) is to utilize laser thermal effect to make the agglomerative a kind of novel oncotherapy technology of local organization.It can reach the purpose that tumor in situ is removed by less intrusion, compares with traditional surgery, the situation of bleeding profusely seldom occurs, and has been used to the oncotherapy at positions such as clinical brain, liver, mammary gland, retina.Studies show that, when the temperature of biological tissue reaches 60 ℃, can cause the wherein Denaturation of protein and collagen protein, destroy the repair mechanisms of cell, what cause organizing condenses and necrocytosis.But when temperature further raise, vaporization and carbonization can take place in tissue.After temperature surpassed 300 ℃, tissue will fusion.Between mainly utilize the thermal coagulation effect of laser in the matter heating therapy, should avoid vaporization, carbonization and the fusion organized as possible.Therefore, in therapeutic process, real time temperature control just becomes one of them crucial problem, but with regard to present technology, the amount of radiation of laser is difficult to measure real-time and accurately or calculate with mathematical method, and in the laser irradiation process, the real-time measurement of tissue temperature also is difficult to realize, can only lean on the experience of therapist to judge at present, these limitations have all increased the danger of treatment.
At this problem, existing technology utilizes the photon transmission theory to explain absorption and the scattering properties of tissue to light by to biological tissue's modeling.For the transmission of photon in biological tissue, the strictest method is to utilize the Maxwell equation group to derive, but its solution procedure is quite complicated, sometimes even can't finish.Transmission theory need not considered the Maxwell equation group, has the characteristics of direct deduction.Method wherein commonly used has Kubelka-Munk theory, one-level scattering, diffusion method of approximation, Monte Carlo method and reverse doubling method etc.Yet, owing to organize anisotropy, and dissimilar tissues is also inequality to thermal characteristics and light characteristic that irradiation laser shows, simultaneously, the blood perfusion rate of dynamic change can influence hot injury's volume in the tissue, so also can there be certain deviation in these analogy methods, and only be useful in the homogeneity tissue (for example liver).In addition, can utilize image technology by the doctor, comprise CT, ultrasonic, magnetic resonance monitoring etc., judge the temperature of tissue according to the color of being organized by irradiation, to determine employed laser power or treatment time, this can introduce certain subjective error.The real time temperature of the institute of biomedical engineering of Miami University during once with the thermal interaction of thermocouple measurement laser and Carnis Sus domestica tissue, wherein exist a main shortcoming to be: the stainless pin of thermocouple can have very strong absorption to the iraser that when treatment uses, thereby produce an ambient temperature noise, though considered interference in the document report, and utilize approximation method to remove temperature noise, but experimental result there is certain influence.And stainless pin can only measure the temperature of a bit, in order to obtain the temperature of whole tissue, needs many thermocouples, and device is complicated and be difficult for realization when LITT treat.Use the fluorescence optical fiber thermometer measure in practice in addition by the temperature of treated tissue, though possess a lot of advantage of optical fiber, but it can only obtain by an average temperature value of area for treatment, the districution temperature that can not reflect area for treatment also just can not guarantee the safety of surrounding health tissue or sensitive part then.
Fiber grating is not subjected to electromagnetic interference with its essential safety, and is highly sensitive, light weight, and volume is little, is easy to multiplexingly, and remote measurement at a distance can be imbedded advantages such as engineering, enjoys the concern of sensory field, is when one of main flow direction of front sensor development.Now developed the temperature Fibre Optical Sensor of many types, theoretical basis has been established by this system of giving.
Summary of the invention:
The present invention is directed to and solve between laser real-time thermometric bottleneck in the matter thermotherapy, provide a kind of simple in structure, make easily, cost is low, high accuracy is high, districution temperature real-time measurement system and data processing method in the laser-induced interstitial thermotherapy of very strong practicality arranged, between laser in the matter thermotherapy process, can observe at any time by the accurate Temperature Distribution of therapentic part, then make right judgement, can guarantee the safety of tumor normal surrounding tissue or sensitive part.
For achieving the above object, the present invention adopts following technical proposals: the system that districution temperature is measured in real time in a kind of laser-induced interstitial thermotherapy comprises LASER Light Source, wideband light source, 5: 5 fiber couplers of 1 * 2, spectrogrph, the computer terminal, passing can multimode fibre and sensor fibre grating.It is characterized in that: the light that described LASER Light Source sends can import in the tumor tissues by multimode fibre by described biography; The grid region of described sensor fibre grating is inserted in the tumor tissues; The light that wideband light source sends is connected to described sensor fibre grating through 5: 5 fiber couplers of one 1 * 2, and its reflectance spectrum is connected on the spectrogrph by optical fiber and shows; Described spectrogrph connects a computer terminal, and the reflectance spectrum data on the spectrogrph is imported in the computer terminal in real time, obtains being treated the districution temperature of tumor locus by the spectrum inversion program.
The grid region length of above-mentioned sensor fibre grating can realize complete distributed temperature sensing greater than 1cm.
Above-mentioned biography energy multimode fibre and sensor fibre grating are made into a treatment terminal, its structure is: described biography can be placed in the glass bushing of a bilayer by multimode fibre, wherein outer layer glass tube is standby, when laser power is big, laser can produce the hot injury to the bright dipping end that passes the energy multimode fibre, at this moment can feed recirculated water and cool off; Described sensor fibre grating is placed in the glass tubing with slit, the grid region is in slot area, guarantee that measured value is the true temperature of tumor tissues, eliminated in addition because of organizing flexibility to produce any deformation to the bending stress that the sensor fibre grating produces, the rising of also having eliminated Yin Wendu causes tumor tissues to shrink the axial stress that the sensor fibre grating is produced; One end adhesive seal of described sensor fibre grating has been fixed the relative position that itself and described biography can multimode fibres, and the other end is placed in the refractive index match glue, eliminates the influence of end reflection light to reflectance spectrum.
Temperature real-time measurement data processing method in a kind of laser-induced interstitial thermotherapy, adopt said system to measure in real time, it is characterized in that temperature sensing fiber grating reflectance spectrum data input computer terminal, the core inversion algorithm that obtains being treated the tumor locus Temperature Distribution by the spectrum inversion program is improved evolution simulated annealing, guarantee to monitor real-time dynamicly the districution temperature of tumor region, the steps include: that the basic theories according to fiber grating calculates the value of temperature, choosing the initial distribution temperature of an optimum carries out iteration; If the resonance peak of fiber grating reflectance spectrum is sparse, the temperature range of every cross-talk grating is provided with greatly, vice versa; Carry out iteration according to evolution simulated annealing, utilize the variation districution temperature of casting out to come the interval of convergence, raise the efficiency.
The present invention has following conspicuous outstanding substantive distinguishing features and remarkable advantage compared with prior art:
Therefore 1. compare computer modeling technique, do not need to consider initial condition, make the LITT treatment also can be used in the heterogeneous tissue, and can monitor real-time dynamicly by the true temperature of area for treatment and change.
2. concerning image technology, this system can be used as auxiliary, because of it can by virtue of experience make the subjective error that the treatment judgement brings thereby eliminated therapist in body monitoring in real time by the variations in temperature of area for treatment.
3. the sensor fibre grating is not imported the influence of laser, thereby the probe of having eliminated thermocouple absorbs the temperature noise that produces behind certain laser in therapeutic process.
4. this system adopts a sensor fibre grating to realize complete distributed measurement, thereby has eliminated many whole loaded down with trivial details problems of detection system that caused by the treated tissue districution temperature of thermocouple measurement that adopt.
5. comparing the quasi-distributed fiber grating temperature sensing measures, adopting the fiber grating and the bonded technology of spectrum inversion algorithm in longer grid region is complete distributed measurement, can survey the Temperature Distribution of whole treated tissue and can monitor its dynamic change in real time, this just makes that also detection system is simple.
6. optical fiber fluorescence temperature sensor can only draw by an average temperature value of treated tissue, and this measuring system can obtain by the districution temperature of area for treatment, has guaranteed the safety of surrounding tissue or sensitive part, has reduced the danger of operation.
7. this measuring system is made easily, the precision height, and cost is low.
Description of drawings:
Fig. 1 is a districution temperature real-time measurement system structural representation in the one embodiment of the invention laser-induced interstitial thermotherapy.
Fig. 2 is by the temperature sensing fiber grating and pass the structural representation of the treatment terminal of can multimode fibre forming.
The specific embodiment:
Referring to Fig. 1, details are as follows in conjunction with the accompanying drawings for a preferred embodiment of the present invention: the system that districution temperature is measured in real time in this laser-induced interstitial thermotherapy comprises LASER Light Source 11, wideband light source 15,5: 5 fiber couplers 16 of 1 * 2, spectrogrph 17, computer terminal 18, passing can multimode fibre 12 and sensor fibre grating 14.Operation principle: the light that LASER Light Source 11 sends imports in the tumor tissues 13 of being treated through energy-transmission optic fibre 12, and tumor tissues 13 can cause that temperature raises after absorbing laser, and according to the photon transmission theory as can be known, the temperature right and wrong of this moment are equally distributed.Fiber grating 14 with longer grid region also is placed in the tumor tissues 13 of being treated, and the light that wideband light source 15 sends enters fiber grating 14 through 5: 5 fiber couplers 16 of 1 * 2, its reflectance spectrum is presented on the spectrogrph 17, because the variation in temperature field makes the grid region diverse location produce different conditioned reflexes in the tumor tissues 13, cause reflectance spectrum to change, then reflectance spectrum data is imported in the computer terminal 18 in real time, be finally inversed by Temperature Distribution on the fiber grating 14 by high efficiency improved evolution simulated annealing, judge thereby treatment made accurately.
In therapeutic process, energy-transmission optic fibre 12 is very important with the relative position of fiber grating 14, and spectrum changes because the variation of position can cause grating reflection, thereby causes erroneous results, so need preparation good curing terminal.Referring to Fig. 2, the structure of treatment terminal is: energy-transmission optic fibre 12 is placed in the glass bushing 21 of a bilayer, and wherein outer layer glass tube is standby, when laser power is big, laser can produce the hot injury to the bright dipping end of optical fiber 12, at this moment can feed recirculated water and cool off.Because tumor tissues 3 is soft, so any deformation all can produce a bending stress to fiber grating 14.In addition, in therapeutic process, because the rising of temperature, tumor tissues can shrink, and can produce an axial stress this moment to fiber grating 14, and the existence meeting of above-mentioned two kinds of stress produces error to the result.In order to eliminate two kinds of stress, and guarantee that energy-transmission optic fibre 12 and fiber grating 14 have fixed relative position, fiber grating is placed in the glass tubing with slit, the grid region is in slot area, so guarantee to measure in real time by the true temperature of treated tissue, and an end is fixing constant with the holding position with binding agent 22, and the other end is placed in the refractive index match glue 23, the influence that the reflected light of elimination fiber grating 14 ends brings.
Temperature real-time measurement data processing method in this laser-induced interstitial thermotherapy, adopt said system to measure, to temperature sensing fiber grating 14 reflectance spectrum data input computer terminal 18, the core inversion algorithm that obtains being treated the tumor locus Temperature Distribution by the spectrum inversion program is improved evolution simulated annealing, guarantee to monitor real-time dynamicly the districution temperature of tumor region, the steps include:
1., calculate the value of temperature, choosing the initial distribution temperature of an optimum carries out iteration according to the basic theories of fiber grating;
If 2. the resonance peak of fiber grating reflectance spectrum is sparse, the temperature range of every cross-talk grating is provided with greatly, vice versa;
3., carry out iteration, utilize the variation districution temperature of casting out to come the interval of convergence, raise the efficiency according to evolution simulated annealing.
Claims (4)
1. districution temperature real-time measurement system in the laser-induced interstitial thermotherapy comprises LASER Light Source (11), wideband light source (15), 5: 5 fiber couplers (16) of 1 * 2, spectrogrph (17), computer terminal (18), passing can multimode fibre (12) and sensor fibre grating (14).It is characterized in that:
1), the light that sends of described LASER Light Source (11) can import in the tumor tissues (13) by multimode fibre (12) by described biography;
2), the grid region of described sensor fibre grating (14) is inserted in the tumor tissues (13);
3), the light that sends of a wideband light source (15) is connected to described sensor fibre grating (14) through 5: 5 fiber couplers (16) of one 1 * 2, its reflectance spectrum is connected to spectrogrph (17) by optical fiber and goes up and show;
4), described spectrogrph (17) connects a computer terminal (18), the reflectance spectrum data on the spectrogrph (17) is imported in the computer terminal (18) in real time, obtains being treated the districution temperature of tumor locus by the spectrum inversion program.
2. districution temperature real-time measurement system in the laser-induced interstitial thermotherapy according to claim 1, the grid region length that it is characterized in that described sensor fibre grating (14) can realize complete distributed temperature sensing greater than 1cm.
3. temperature real-time measurement system in the laser-induced interstitial thermotherapy according to claim 1 is characterized in that described biography energy multimode fibre (12) and sensor fibre grating (14) are made into a treatment terminal, and its structure is:
1., described biography can be placed in the glass bushing (21) of a bilayer by multimode fibre (12), wherein outer layer glass tube is standby, when laser power was big, laser can produce the hot injury to the bright dipping end that passes energy multimode fibre (12), at this moment can feed recirculated water and cool off;
2., described sensor fibre grating (14) is placed in the glass tubing with slit, the grid region is in slot area, guarantee that measured value is the true temperature of tumor tissues, eliminated in addition because of organizing flexibility to produce any deformation to the bending stress that sensor fibre grating (14) produces, the rising of also having eliminated Yin Wendu causes tumor tissues to shrink the axial stress that sensor fibre grating (14) is produced;
3., an end of described sensor fibre grating (14) is with binding agent (22) sealing, fixed its with described biography can multimode fibre (12) relative position, the other end is placed in the refractive index match glue (23), elimination end reflection light is to the influence of reflectance spectrum.
4. temperature real-time measurement data processing method in the laser-induced interstitial thermotherapy, employing is measured in real time according to temperature real-time measurement system in the described laser-induced interstitial thermotherapy of claim 1, it is characterized in that temperature sensing fiber grating (14) reflectance spectrum data input computer terminal (18), the core inversion algorithm that obtains being treated the tumor locus Temperature Distribution by the spectrum inversion program is improved evolution simulated annealing, guarantee to monitor real-time dynamicly the districution temperature of tumor region, the steps include:
1., calculate the value of temperature, choosing the initial distribution temperature of an optimum carries out iteration according to the basic theories of fiber grating;
If 2. the resonance peak of fiber grating reflectance spectrum is sparse, the temperature range of every cross-talk grating is provided with greatly, vice versa;
3., carry out iteration, utilize the variation districution temperature of casting out to come the interval of convergence, raise the efficiency according to evolution simulated annealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100503531A CN101569523B (en) | 2009-04-30 | 2009-04-30 | System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100503531A CN101569523B (en) | 2009-04-30 | 2009-04-30 | System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101569523A true CN101569523A (en) | 2009-11-04 |
| CN101569523B CN101569523B (en) | 2011-02-02 |
Family
ID=41229111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100503531A Active CN101569523B (en) | 2009-04-30 | 2009-04-30 | System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101569523B (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102032954A (en) * | 2010-12-28 | 2011-04-27 | 上海大学 | Method for inverting and demodulating temperature field by fiber Bragg grating fast spectrum |
| CN102081415A (en) * | 2010-12-29 | 2011-06-01 | 上海大学 | Real-time distributed temperature control system during laser-induced interstitial thermotherapy |
| CN103181756A (en) * | 2011-12-30 | 2013-07-03 | 武汉奇致激光技术有限公司 | Non-contact real-time temperature-measuring treatment hand tool for laser fungal treatment |
| CN108325089A (en) * | 2018-01-03 | 2018-07-27 | 南通大学 | A kind of tumour laserthermia and multi-parameters real-time monitoring probe |
| CN108577964A (en) * | 2018-04-25 | 2018-09-28 | 南京市口腔医院 | Semiconductor laser therapeutic instrument, control method and temperature signal processing method |
| CN109843143A (en) * | 2016-12-09 | 2019-06-04 | 直观外科手术操作公司 | The system and method for distributed heat flux-sensing for bodily tissue |
| CN109870431A (en) * | 2019-02-25 | 2019-06-11 | 桂林电子科技大学 | Multi-core optical fiber cell sensor with cone rotary table fibre end structure |
| CN109901279A (en) * | 2019-02-25 | 2019-06-18 | 桂林电子科技大学 | Microballoon self assembly laser based on coaxial three waveguide fiber |
| CN109946271A (en) * | 2019-02-25 | 2019-06-28 | 桂林电子科技大学 | A kind of multi-core optical fiber cell sensor with non-equilateral pyramid optical fiber end structure |
| CN111445754A (en) * | 2020-04-30 | 2020-07-24 | 中国医学科学院生物医学工程研究所 | Auxiliary training system for simulating laser surgery |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3375995B2 (en) * | 1992-11-25 | 2003-02-10 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Medical temperature sensor |
| CN1472552A (en) * | 2003-06-24 | 2004-02-04 | 重庆大学 | Singe lnog period optical fiber gratings based simultaneous temperature and load measuring method and sensor |
| CN1632485A (en) * | 2004-12-10 | 2005-06-29 | 淄博思科电子技术开发有限公司 | Distributed optical fiber grating temperature detection system for high voltage electric power equipment |
| US20080058602A1 (en) * | 2006-08-30 | 2008-03-06 | Karl Storz Endovision | Endoscopic device with temperature based light source control |
-
2009
- 2009-04-30 CN CN2009100503531A patent/CN101569523B/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102032954A (en) * | 2010-12-28 | 2011-04-27 | 上海大学 | Method for inverting and demodulating temperature field by fiber Bragg grating fast spectrum |
| CN102032954B (en) * | 2010-12-28 | 2012-07-11 | 上海大学 | Method for inverting and demodulating temperature field by fiber Bragg grating fast spectrum |
| CN102081415A (en) * | 2010-12-29 | 2011-06-01 | 上海大学 | Real-time distributed temperature control system during laser-induced interstitial thermotherapy |
| CN103181756A (en) * | 2011-12-30 | 2013-07-03 | 武汉奇致激光技术有限公司 | Non-contact real-time temperature-measuring treatment hand tool for laser fungal treatment |
| CN103181756B (en) * | 2011-12-30 | 2015-07-22 | 武汉奇致激光技术有限公司 | Non-contact real-time temperature-measuring treatment hand tool for laser fungal treatment |
| CN109843143A (en) * | 2016-12-09 | 2019-06-04 | 直观外科手术操作公司 | The system and method for distributed heat flux-sensing for bodily tissue |
| CN108325089A (en) * | 2018-01-03 | 2018-07-27 | 南通大学 | A kind of tumour laserthermia and multi-parameters real-time monitoring probe |
| CN108577964A (en) * | 2018-04-25 | 2018-09-28 | 南京市口腔医院 | Semiconductor laser therapeutic instrument, control method and temperature signal processing method |
| CN109870431A (en) * | 2019-02-25 | 2019-06-11 | 桂林电子科技大学 | Multi-core optical fiber cell sensor with cone rotary table fibre end structure |
| CN109901279A (en) * | 2019-02-25 | 2019-06-18 | 桂林电子科技大学 | Microballoon self assembly laser based on coaxial three waveguide fiber |
| CN109946271A (en) * | 2019-02-25 | 2019-06-28 | 桂林电子科技大学 | A kind of multi-core optical fiber cell sensor with non-equilateral pyramid optical fiber end structure |
| CN111445754A (en) * | 2020-04-30 | 2020-07-24 | 中国医学科学院生物医学工程研究所 | Auxiliary training system for simulating laser surgery |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101569523B (en) | 2011-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101569523B (en) | System for measuring distribution temperature in real time in laser-induced interstitial thermotherapy and data processing method | |
| Bianchi et al. | Quasi-distributed fiber optic sensor-based control system for interstitial laser ablation of tissue: theoretical and experimental investigations | |
| West et al. | Monitoring tissue temperature during photothermal therapy for cancer | |
| CN104840251A (en) | Laser thermal therapy probe based on photothermal effect of optical fiber material | |
| Feng et al. | Nanoshell-mediated laser surgery simulation for prostate cancer treatment | |
| Gassino et al. | A fiber optic probe for tumor laser ablation with integrated temperature measurement capability | |
| Saccomandi et al. | Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue | |
| Nguyen et al. | Temperature feedback-controlled photothermal treatment with diffusing applicator: theoretical and experimental evaluations | |
| Gould et al. | Optical-thermal light-tissue interactions during photoacoustic breast imaging | |
| Liu et al. | Determination of temperature distribution in tissue for interstitial cancer photothermal therapy | |
| Jelbuldina et al. | Real-time temperature monitoring in liver during magnetite nanoparticle-enhanced microwave ablation with fiber bragg grating sensors: ex vivo analysis | |
| Hood et al. | Intracranial hyperthermia through local photothermal heating with a fiberoptic microneedle device | |
| CN209734770U (en) | Power-tunable laser moxibustion device | |
| Alqarni et al. | Self-monitored and optically powered fiber-optic device for localized hyperthermia and controlled cell death in vitro | |
| Korganbayev et al. | Tilted Fiber Bragg grating measurements during laser ablation of hepatic tissues: Quasi-distributed temperature reconstruction and cladding mode resonances analysis | |
| Katrenova et al. | Status and future development of distributed optical fiber sensors for biomedical applications | |
| Kosir et al. | Towards personalized and versatile monitoring of temperature fields within heterogeneous tissues during laser therapies | |
| Moore et al. | Light penetration in the human prostate: a whole prostate clinical study at 763 nm | |
| Namakshenas et al. | Fiber Bragg grating sensors-based assessment of laser ablation on pancreas at 808 and 1064 nm using a diffusing applicator: experimental and numerical study | |
| Jelbuldina et al. | Fiber Bragg Grating Sensor for Temperature Monitoring During HIFU Ablation of Ex Vivo Breast Fibroadenoma | |
| Kim et al. | In vivo outcome study of BPD-mediated PDT using a macroscopic singlet oxygen model | |
| CN102081415A (en) | Real-time distributed temperature control system during laser-induced interstitial thermotherapy | |
| Lyu et al. | Accurate analysis of limiting human dose of non-lethal laser weapons | |
| US10687895B2 (en) | Integrated fiber optic probe for performing image-guided laser induced thermal therapy | |
| Ding et al. | Dynamic temperature monitoring and control with fully distributed fiber Bragg grating sensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |