CN101565388B - 2-芳基丙腈类化合物的制备方法 - Google Patents
2-芳基丙腈类化合物的制备方法 Download PDFInfo
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- CN101565388B CN101565388B CN2009100523728A CN200910052372A CN101565388B CN 101565388 B CN101565388 B CN 101565388B CN 2009100523728 A CN2009100523728 A CN 2009100523728A CN 200910052372 A CN200910052372 A CN 200910052372A CN 101565388 B CN101565388 B CN 101565388B
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- benzyl cyanide
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- methylcarbonate
- ionic liquid
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- 0 *Cc1ccccc1 Chemical compound *Cc1ccccc1 0.000 description 2
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
离子液体(IL)a | 转化率(%) | 选择性(%) | 收率(%) | 副产物(%) |
- | - | - | - | - |
[Bmim]OAc | 98 | 100 | 98 | no |
[Bmim]Cl | 96 | 100 | 96 | no |
[Bmim]Br | 76 | 92 | 70 | 1 |
[Pmim]I | 59 | 100 | 59 | no |
[Bmim]BF4 | 100 | 60 | 60 | 40 |
反应温度(℃)a | 转化率(%) | 选择性(%) | 收率(%) |
90 | Traces | -- | Traces |
110 | 30 | 92 | 28 |
120 | 75 | 100 | 75 |
130 | 98 | 100 | 98 |
150 | 99 | 100 | 99 |
催化剂用量(mmol) | 选择性(%) | 收率(%)a |
0.02 | 100 | 82 |
0.04 | 100 | 91 |
0.06 | 100 | 94 |
0.1 | 100 | 96 |
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CN2009100523728A CN101565388B (zh) | 2009-06-02 | 2009-06-02 | 2-芳基丙腈类化合物的制备方法 |
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CN2009100523728A CN101565388B (zh) | 2009-06-02 | 2009-06-02 | 2-芳基丙腈类化合物的制备方法 |
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CN101565388A CN101565388A (zh) | 2009-10-28 |
CN101565388B true CN101565388B (zh) | 2012-03-07 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102766040A (zh) * | 2012-07-04 | 2012-11-07 | 天长市禾益化学药品有限公司 | 洛索洛芬关键中间体2-对甲苯基丙酸的新合成方法 |
CN103274964B (zh) * | 2013-06-13 | 2014-07-02 | 苏州大学 | 一种制备α-氰基胺的方法 |
CN103408480A (zh) * | 2013-07-17 | 2013-11-27 | 张家港威胜生物医药有限公司 | 4-苯基-吡咯烷酮的合成工艺 |
CN104262198B (zh) * | 2014-09-12 | 2016-01-06 | 柳州丰康泰科技有限公司 | 一种2-(4-甲基苯基)丙腈的生产工艺 |
CN107137387B (zh) * | 2017-07-07 | 2020-05-12 | 中国科学技术大学 | 一种芳基丙酸类非甾体抗炎药的合成方法 |
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