CN101553210A - Methods and systems of delivering medication via inhalation - Google Patents

Abstract

Systems and methods for delivery of a drug to the respiratory system of a patient where the drug is supplied at a positive pressure relative to atmospheric pressure are provided. In particular, the drugs are delivered to the respiratory system of a patient who is capable of unassisted breathing. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the air stream in aerosol, nebulized, or vaporized form.

Description

The method and system of delivering medication via inhalation

Related application

The application is that the application number of submitting on October 25th, 2006 is the part subsequent application of the patent application (it requires the application number of JIUYUE in 2006 submission on the 20th is the priority of the provisional application of No.60/826271) of No.11/552871.

Technical field

The disclosed content of the application relates to by sucking carries medicine.Particularly, it relates to the medicament delivery method that purifying air and can in time adjust according to the breath cycle of user that uses malleation.

Background technology

The application's applicant patent application early has realized that the dire consequences of the air (no matter being by the chemical reagent pollution or by the biopathogen body pollution) of pollution to our health, and has proposed the new family of air cleaning system.Particularly, because the industrial revolution, human respiratory system has continued to be exposed to high strength by in the airborne pollution.For the people that live in city or suburb today, all can not flee from airborne pollutant such as microgranular waste gas, many other pollutant in ozone, dust, mycete and the outdoor urban air.Studies show that, even in most of affluent city residents' dwelling house, room air possibility and usually dirtier than outdoor air.As the problem of reality, lived in resident in the city (no matter developed country or developing country are no matter also their wealth how) and continue dirty air influence without any defence.The air pollution situation that most in the world rural area exists is identical as those problems of finding in the city, in part because these rural areas are positions of fossil-fuel-electric generating plant, and factory and the automobile without any the effectively pollution control that extensively exist in developing country.

In fact, studies show that by breathing contaminated air not only exist directly, influence immediately, for example, cause, but also have secular consequence by being exposed in airborne pathogen or the toxic gas.Human respiratory system has no time to evolve out can be to the defense function of the air pollutants of today, the result, publilc health is subjected to the puzzlement of various pulmonary disease, comprise asthma and lung fibrosis and other diseases such as cancer, flu and by since the ill probability of the influenza that the suck pollution thing causes increase.

Except short-term and long-term consequence, it is also understood that, directly be exposed to contaminated airborne people though some pollutant only influence, other pollutant cause transmissible disease such as some pathogen, have the probability that progressively rises to national pandemic.

As the response to these danger, the application's applicant has developed and has been used to user that the portable respiration device family of clean air is provided.But except removing harmful substance, more advantages can realize by further benefit materials (for example medicine) being joined in the air that has cleaned.

The structure of pulmonary helps gas exchange, the exchange of particularly earn a bare living required oxygen and carbon dioxide.The surface area of adult's lung is at (between 538 and 1076 square feet) between 50 and 100 square metres.This surface area can be equal to the square feet number in little room.The surface area of the adult male skin that the surface area ratio of lung is medium-sized is big 25 to 50 times.This vast surface area of pulmonary makes it become the selected objective target that the medicine whole body is carried.The mankind recognize the ability that pulmonary absorbs the drug well.Only just there are 400,000,000,000 medicated cigarettes to sell in the U.S. in calendar year 2001.Because the human hope that absorbs for the general of nicotine drives the sale of medicated cigarette.Nicotine is not unique medicine that is absorbed by pulmonary easily.The medicine of other abuses also may preferentially be sucked because they be absorbed into easily in the blood flow and be transported to brain rapidly and needn't experience oral digestion medicine suffered because the influence that the liver metabolism is produced.

In history, the suction path of drug conveying has been used to treat pulmonary disease.It also is a preferred path for the non-intruding drug conveying that the general of medicine is carried.This can allow the treatment of other tract various diseases except that pulmonary.The advantage that sucks the path comprises fast Absorption, avoid by liver metabolism and relevant with intravenous injection or the intramuscular injection path complication that do not accommodate.

Owing to lack practical conveyer device, the suction path that is used for the general conveying of medicine up to now is not fully exploited.Most of popular approach that conveying is inhaled into medicine comprise aerosol apparatus, pressurization multi-dose inhaler and Diskus.Every kind of device all is accompanied by and makes it use complicated a plurality of problems.In addition, these install also to exist when clinical use and make its complicated common technique obstacle.The total obstacle of the medicament delivery method that all are present is it and the collaborative mutually difficulty of patient's breathing pattern, medicine and the interaction that pollutant comprise ozone and the dependency (this is difficult for having those impaired patients of respiratory system) that the required energy of suction medicine is provided to the patient of conveying.

Aerosol apparatus uses gas-pressurized to form diameter less than 5 microns sucked droplet aerosol.Ultrasonic nebulizer also is developed, but since they can not spray and can not be used the suspension preparation.The complicated problem of use of gas-pressurized aerosol apparatus is comprised owing to the needs to compressed gas source, limit its portability to a great extent; In order to prevent that bacteria breed need be to installing frequent cleaning; The poor designs that spread unchecked in market, make the cheap aerosol apparatus and the continuous variation (the instillation dosage that 20-25% is mostly just arranged) of delivered dose in expensive system.

The multi-dose inhaler that pressurizes in history is the prevailing induction system that is used to suck medicine.Chlorofluorocarbons (CFCs) is used as the vehicle that is used for these devices at first, but for the consideration to environment, these devices are substituted subsequently.This pill carrying method causes the extensive variation of the dose aspect that is transported to the patient.The pill dose regimen of carrying based on the pill relevant with sucking circulation was deposited in the different parts of lung tree along with the time.Therefore, the dosage of internal deposition in respiratory tract with in laboratory installation, measure different.Textbook education and practical application are subject matter.Effective ratio of " joining and deciding dosage " disappears in mouthpiece and oropharynx.Developed spacer and conservator to attempt to improve this technology, still needed effort but will reach hight coordinate.

Diskus is attempted by making passive improvement of system make medicine coordinate this needs of carrying.In other words, the patient provides and conducts drugs to the required power of pulmonary.Have multiple Diskus on the market, they all have patented technology and design.This complexity that causes itself is, if the patient need take in multiple medicine, they may the multiple different technologies of study.In addition, the small size powder dose is measured accurate like that not as liquid dosages.Be subjected to the atmospheric environment condition effect at last, especially humidity can influence the drug dose that arrives pulmonary.Can influence drug conveying as simple mistake breath in the device.

Be apparently, by from air, removing noxious pollutant, it is offered user with malleation, in the breath cycle process, adding benefit materials constantly so that optimize advantage and efficient then, realizing being used to improving the optimum condition of the health of countless individualities with the concentration of accurate control and correct.The application seeks to address the above problem.

Summary of the invention

The application discloses and has been used at high purity air being the method and system of the conveying pharmaceutical composition of malleation with respect to atmospheric pressure.In some exemplary embodiments, provide the method and system that is used for carrying pharmaceutical composition at high-purity ozone free air.

A kind of method of pharmaceutical composition administration comprises the following steps: to provide pharmaceutical composition with gaseous state, steam, atomizing or aerosol form; Pharmaceutical composition is incorporated in the purifying gas flow of air that the particle size that is filtered to existence is no more than about 10-20 nanometer; And the pharmaceutical composition in sucking purifying gas flow is administered into pharmaceutical composition the host who needs treatment.In one embodiment, the pharmaceutical composition that volume is very little is transferred with the very large air-flow of volume, allows it to reach with respect to the splendid dosage control of joining the inhaler (MDI) of deciding dosage.

Except with accurate dose control and highly purified air-flow in conjunction with, open system of the present invention also provides the parts that are used for accurately controlling the temperature and humidity of the air that is fed to user.In addition, system disclosed by the invention (for example through control circuit) can allow delivered dose with synchronous with the breath cycle of user, for example allows medicine only to flow to user in breathing process.Conveying is auxiliary by the malleation that produces in system, thereby needs user firmly hardly.This particular importance patient's (little or old) when being in extreme age and those people that spirit is undesired or intelligence is limited.

A kind of embodiment that is used for the system of pharmaceutical composition conveying comprises as follows: the purifying gas flow generator that is used to produce the malleation filtered airflow, face shield that is connected with air source through flexible pipe or other conduits and the parts that are used for medicine is incorporated into gaseous state, steam, atomised form air-flow.

Particularly, embodiment disclosed by the invention comprises the method for drug administration to patient's respiratory system, wherein drug use supply with being that purifying air of malleation carried with respect to atmospheric pressure.Other embodiment of the present invention comprise the respiratory system of drug administration to the patient, comprise that use is to conduct drugs to the patient with respect to purifying air of atmospheric malleation supply, its Chinese medicine is transferred with the air-breathing part of timely and patient's breath cycle synchronous, and wherein the information from one or more devices of monitoring patient's states is used to regulate speed and the time of drug conveying to the patient.

Embodiment disclosed by the invention also comprise by with medicine with respect to atmospheric pressure be malleation flow to the patient with the method and apparatus of drug administration to patient's respiratory system, wherein the patient can not have auxiliaryly and breathes.In an embodiment, medicine with respect to atmospheric pressure be malleation air, purify air or admixture of gas in be supplied to.

On the basis of checking following accompanying drawing and detailed description, other system disclosed by the invention, method, feature and advantage will be conspicuous for a person skilled in the art.All described other systems, method, feature and advantage all comprise in this manual, all belong to scope disclosed by the invention, and are protected by appending claims.

Description of drawings

Can understand many aspects disclosed by the invention better with reference to accompanying drawing.Element in the accompanying drawing does not need to draw in proportion, and Special attention will be given to (rather than installation) is in order to be clearly shown that principle of the present invention.In addition, in the accompanying drawings, identical Reference numeral shows similar elements at institute's drawings attached invading the exterior.

Fig. 1 has shown the 3-D view of the aerosol jar that contains albuterol (albuterol) that is used for the treatment of asthma of prior art.

Fig. 2 A shows the front view of system of the present invention, and Fig. 2 B has shown its side view.

Fig. 3 has shown the front view of the embodiment of disclosed device.

Fig. 4 has shown the partial side view of the embodiment of disclosed medical port (medi port).

Fig. 5 has shown the partial side view of a kind of embodiment of adapter of the mixing chamber of the medical port that is used for Fig. 4.

Fig. 6 has shown the partial side view of the embodiment of disclosed mixing chamber.

Fig. 7 has shown the partial side view of embodiment of the adapter of the mixing chamber that is used for Fig. 6.

Fig. 8 has shown the partial side view of the embodiment of disclosed medical port.

Fig. 9 has shown the partial side view of the embodiment of disclosed mixing chamber.

Figure 10 has shown the partial side view of embodiment of the adapter of the mixing chamber that is used for Fig. 9.

Figure 11 has shown the partial side view with the embodiment of hose connection medical port.

Figure 12-14 shows the embodiment of medical port disclosed by the invention.

Figure 15 and 16 shows the partial side view of the embodiment of disclosed medical port.

Figure 17 shows side view and the front view of the embodiment of the disclosed medical port that is connected with the embodiment of face shield of the present invention.

Figure 18 shows side view and the front view of the another kind of embodiment of the disclosed medical port that is connected with the embodiment of face shield of the present invention.

Figure 19 shows the embodiment of system disclosed by the invention, and wherein medical port is configured for networked data communication.

Figure 20 has shown that with a plurality of disposable injections be feature so that carry the embodiment of the medical port of multiple medicine.

Figure 21 has shown the aerator that utilizes air vessel or air bag and the embodiment of medical port.

Figure 22 is for the filter efficiency of the microgranule of the 100nm that the is used for tested standard filtering material figure to cover wind speed (face velocity).

The specific embodiment

Before describing disclosed the present invention in detail, be to be understood that to the invention is not restricted to described specific embodiment, can comprise various variations certainly since so.Scope of the present invention it is also understood that the technical term that uses in this article only is used to describe the purpose of specific embodiment, rather than limits it, because will only be limited by appending claims.

When relating to numerical range, it is understood that each all is included among open the present invention between the numerical value between the bound of this scope (the tenth numerical value (unless clearly indicating in addition) until lower limit unit) and any other setting in this statement scope or the value of insertion.These upper and lower bounds more among a small circle are in (submitting to any numerical range that does not limit especially in this set point) can be included in more independently and be also included within the open scope of the present invention.When set point comprised one or two of bound, one or two the scope in those bounds that comprised was not also included among the present invention.

Unless special definition, all technology used herein and scientific and technical terminology are with identical by the common implication of understanding of person of an ordinary skill in the technical field disclosed by the invention.Though similar or be equal in this article those methods and the material described and all can be used in practice or in the test of the present invention, describe with method for optimizing and material now.

All publications quoted as proof in this manual and patent are here by reference and combination, special and independently point out it by reference and combination as each independent publication or patent, and by combined with method and/or material relevant in the publication that is cited with reference to its disclosure and description.Quoting of any publication all is disclosed before the submission date, and is not appreciated that owing to disclose background technology, and admits the present invention owing to be not authorized to by the described open of prior art.In addition, the date of the publication that is provided can be different with the actual publication date that may need independent affirmation.

When reading when of the present invention as conspicuous for a person skilled in the art, the single embodiment of each that describe and illustrate has discrete element and feature in this article, they can be easy to separate or with some other embodiment in any one characteristics combination, do not depart from scope of the present invention or spirit yet.The method of any statement can realize in proper order with the order of the incident of statement or with possible other in logic.

The following examples are illustrated so that how to implement medication and how to use the open and claimed in this article compositions and the complete disclosure and description of chemical compound for those skilled in the art provide.Made relevant effort and guaranteed the accuracy of relevant data (for example amount, temperature etc.), but some wrong and deviations also should be considered.Except as otherwise noted, part be weight portion, temperature is ℃, and pressure is atmospheric pressure or near atmospheric pressure.Standard temperature and pressure (STP) are defined as 20 ℃ and 1 atmospheric pressure.

Except as otherwise noted, embodiment disclosed by the invention will adopt Synthetic Organic Chemistry, biochemistry, pharmacology, materia medica and the similar techniques in the ordinary skill in the art scope.These technology are all explained in the literature.

Be that as what use in description and appending claims, unless clearly indicate in addition in context, singulative " ", " one " and " this " comprise the object of plural form with must be noted that.Therefore, for example, comprise a plurality of supports with reference to " support ".In this manual and in claims thereafter, unless tangible meaning contradiction is arranged, the implication of some terms will be following reference.

Before describing each embodiment, be provided to give a definition, unless specialize, it will be used.

Definition:

Term " aerosol " refers to the suspension of solid in the gas or liquid particle in this article.

Term " hereditary material " generally refers to the chemical compound that comprises bioactive ingredients in this article, includes but not limited to nucleic acid (for example strand or double-stranded DNA or RNA or siRNA), protein, peptide, polypeptide and analog.

In this article, term " surfactant " or " pulmonary surfactant " are commonly referred to as necessary specificity lipoprotein material in the natural generation of pulmonary for suitable breathing, alveolar stability and gas exchange.Pulmonary surfactant is to reduce capillary surfactant by the natural gas-liquid interface place at alveolar that forms of II type i alveolar cell.Pulmonary surfactant generally is made up of 90% lipid (wherein only about half of is phospholipid dipalmitoyl phosphatidyl choline (DPPC)) and about 10% protein.At least four kinds of natural surfactants are determined: SP-A, B, C and D.Hydrophobic surface activated protein B (SP-B) and C (SP-C) combine closely with phospholipid, and promote them to absorb in the gas-liquid interface of alveolar.These protein are crucial for the formation of surface-active film.Term " surfactant " also comprises present available surface activity preparation, includes but not limited to:

(A-60386X), (calfactant), Exosurf

(Colfosceril Palmitate), (Gu Er Soviet Union), (lucinactant),

(atomizing

),

(lusupultide), And the preparation of developing (bovactant).

In this article, term " purifies air " and refers to by the synthetic air of pure gas or be filtered to reduce particle matter and/or other pollutant such as but not limited to ozone, SO ₂And NO ₂Surrounding air.Though described pollutant may not be removed fully/eliminate, its amount reduces than the amount of finding in the air in specific environment, and preferably makes airborne pollutant reduce by using HEAP level filter to filter.In some preferred embodiments, compare with the amount of particle matter in the surrounding air to be clean, the purification air comprises and is less than about 0.03% have greater than the about particle matter of the particle size of 20nm.In some preferred embodiments, the purification air comprises the particle number that is less than about 0.0001% surrounding air to be clean.In an embodiment, compare with surrounding air to be clean, purifying air comprises the ozone of decrement.In certain embodiments, compare with surrounding air to be clean, purifying air comprises the SO of decrement ₂, and in certain embodiments, compare with surrounding air to be clean and to comprise the NO of decrement ₂In some preferred embodiments, purify air and have the ozone of decrement, the SO of decrement ₂And/or the NO of decrement ₂, and compare particle number with surrounding air to be clean and be less than about 0.03%.

In this article, term " malleation " refers to the pressure of the air that is provided for the patient greater than atmospheric pressure.

In this article, term " user ", " host " and/or " patient " comprise needs treatments and can be ventilated or use the mankind and the other biological of disclosed respiratory organ.Particularly, term " user ", " host " and/or " patient " comprise human and mammal (for example cat, Canis familiaris L., horse, chicken, pig, barren sow, cattle and other domestic animals).

In this article, term " medicine " generally refers to compounds effective on any materia medica that uses in the treatment of any disease or state.For example, medicine can use in disease treatment, uses in the treatment such as the asthma in many other states, bronchitis, emphysema, pulmonary infection, cystic fibrosis, a-1 antitrypsin (ATT) shortage, senile chronic occlusive disease (COPD), acute respiratory distress syndrome (ARDS), idiopathic respiratory distress of newborn syndrome (IRDS), fetus biparietal diameter (BPD) and meconium suction syndrome (MAS).The useful medicine that Jing Guo the suction of open method is transferred according to the present invention includes but not limited to: those that enumerate in by the Physician ' s Desk Reference of Thomson PDR publication (version of most recent, for example 2007).Those that described medicine includes but not limited to illustrate in the table 1 below, its medicine can use disclosed device with relevant indication administration.Table 1 provides can be through the tabulation of the typical medicaments of disclosed device conveying at once, and all these medicines are all confirmed by FDA (Food and Drug Adminstration) with regard to pulmonary delivery.Other drug that in existing disclosed method, uses and following enumerate and non exhaustive.

Table 1

Albuterol ALBUTEROL	Be used to alleviate or prevent to suffer from the bronchospasm that reversibility is blocked the patient of airway disease; The acute attack of bronchospasm (suction solution); The prevention of exercise induced bronchospasm.
		Salbutamol sulfate ALBUTEROL SULFATE	Be used to alleviate and suffer from 2 years old or above patient's the bronchospasm and the acute attack of bronchospasm that reversibility is blocked the airway disease.Be used for the treatment of or prevent to suffer from the bronchospasm that reversibility is blocked the adult of airway disease or 4 years old or above patient, and be used to prevent 4 years old or above patient's exercise induced bronchospasm.
Atropine sulfate ATROPINE SULFATE	Be used for the treatment of or prevent to suffer from the bronchospasm that reversibility is blocked the adult of airway disease or 4 years old or above patient, and be used to prevent 4 years old or above patient's exercise induced bronchospasm.
		Bitolterol mesilate BITOLTEROL MESYLATE	Be used for prevention and treatment bronchial asthma and reversibility bronchospasm.Can be simultaneously and the treatment of theophylline or steroid.

Budesonide BUDESONIDE	In adult and 6 years old or above pediatric patients, be used for the treatment of keeping of asthma as prophylactic treatment.
		Sodium cromoglicate CROMOLYN SODIUM	Preventive administration as bronchial asthma.Cromoglicic acid is administered into the patient that trouble needs the frequent symptom of continuous therapeutic scheme regularly every day.For the acute bronchus spasm of preventing to cause by motion, toluene diisocyanate, environmental contaminants and known antigens.
Desflurane DESFLURANE	For inducing or keep being grown up inpatient and the operating anesthesia of outpatient.
		Dexamethasone sodium phosphate DEXAMETHASONE SODIUM PHOSPHATE	Keep treatment of asthma, as 5 years old or above patient's prophylactic treatment medicine.
Dornase Alfa DORNASE ALFA	The suggestion with administration every day of the bonded Dornase Alfa of standard care in the patient's of cystic fibrosis treatment to improve pulmonary function.In suffering from 40% forced vital capacity (FVC) patient who surpasses or equal to predict, administration every day of Dornase Alfa also shows the respiratory tract infection risk of reduction to parenteral antibiotic needs.
		Enflurane ENFLURANE	Be used to induce and keep general anesthesia.Enflurane can be used to be provided for providing the anesthesia of vaginal delivery.The enflurane of low concentration also can be used to the auxiliary of in the cesarean section delivery process other anesthetic,generals.The enflurane of high concentration can cause hysteranesis and increase metrorrhagia.
Momestasone furoate MOMETASONE FUROATE	Be used for the treatment of keeping of asthma as 12 years old or above patient's prophylactic treatment agent.It is required that Eloson (Mometasone) also is required the asthmatic patient of oral corticosteroid treatment agent, and wherein the Eloson of Jia Ruing (Mometasone) therapeutic agent can reduce or eliminate the needs for oral corticosteroid.
		Sodium nedocromil NEDOCROMIL SODIUM	Be used for suffering from slightly to the adult of moderate asthma or 6 years old or the processing of above pediatric patients keep treatment.
Nitric oxide NITRIC OXIDE	Nitric oxide and other oxygenation holders and other suitable reagent is in conjunction with being used to suffer from the mature of the anoxia respiratory failure relevant with clinical or ultrasoundcardiogram (ECG) evidence of pulmonary hypertension or near the neonatal treatment of mature (surpassing for 34 weeks), and wherein it has improved Oxygenation and the minimizing needs to external film oxidation.
		The pentylenetetrazol isethionate	Be used for excessive risk Chinese mugwort by following one or two standard definition

PENTAMIDINE ISETHIONATE	Grow virus (HIV) infected patient and pneumocystis carinii pneumonia (PCP): this or the history of PCP outbreak repeatedly.Periphery CD4+ (T4 auxiliary/inducer cell) lymph number is less than or equals 200/mm 3
		Calcium trisodium pentetate PENTETATE CALCIUM TRISODIUM	Calcium trisodium pentetate is used to increase the clearance rate for the internal pollution of suffering from known or doubtful plutonium, americium or curium.
Pentetic acid zinc trisodium PENTETATE ZINC TRISODIUM	Be used to increase clearance rate to the internal pollution of suffering from plutonium, americium or curium.
		Pirbuterol acetate PIRBUTEROL ACETATE	Be used to suffer from that the reversibility bronchospasm comprises 12 years old of asthma or the prevention and the reverse of above patient's bronchospasm.It can combinedly be used to have or do not have the treatment of concurrent theophylline and/or hydrocortisone.
Virazole RIBAVIRIN	Be used to suffer from the baby and of being in hospital of the serious lower respiratory infection that causes by respiratory syncytial virus (RSV) than the treatment of small children.
		The new naphthalene Fitow of salmaterol SALMETEROL XINAFOATE	Be used for keeping treatment of asthma and suffering from that reversibility is blocked 4 years old of the airway disease or the prevention of above patient's (comprising patient) bronchospasm secular, twice (morning and night) administration every day with the property sent out asthma at night.
Sevoflurane SEVOFLURANE	In adult and child, induce and keep general anesthesia to be used for inpatient and outpatient's surgical operation.
		Tetrahydrocannabinol TETRAHYDROCANNABI NOL	Be used for the treatment with the relevant apositia that loses weight the patient who suffers from acquired immune deficiency syndrome (AIDS) (AIDS); And be used for the treatment of and follow that cancer chemotherapy causes and can not produce the patient's of abundant effect nausea and vomiting the treatment of conventional emesis.
Tiotropium bromide TIOTROPIUM BROMIDE MONOHYDRATE	Separately or with other bronchiectasis medicines especially beta adrenergic as bronchodilator, be used for the treatment of keeping of the bronchospasm relevant, comprise chronic tracheitis and emphysema with senile chronic occlusive disease (COPD).
		Tobramycin TOBRAMYCIN	Be used to the to suffer from Pseudomonas aeruginosa treatment of patient's cystic fibrosis of (P.aeruginosa).
Triamcinolone TRIAMCINOLONE ACETONIDE	In keeping treatment of asthma as the prophylactic treatment agent; The asthmatic patient that is used for general hydrocortisone in the needs, wherein the hydrocortisone of adding or suction can reduce or eliminate the needs for the general hydrocortisone.

Zanamivir ZANAMIVIR

Be used for the treatment of by influenza virus A and B and cause and symptom is no more than 2 days adult and child's general acute illness more than 7 years old.

Be used for the medicine of pulmonary delivery the other drug that can carry out pulmonary delivery of institute's reference, those that include, but are not limited in following table 2, provide except above-named by disclosed method by the FDA permission.

Table 2

The 2-penicillin F	A/t/s, erythromycin	1: PN: WO02056903 PAGE: 25 claimed protein (abarelix)
			Urokinase (abbokinase)	Amphotericin B lipid complex (abelcet)	Aripiprazole (abilify)
Paclitaxel conjugated protein (abraxane)	Docosanol (abreva)	Accolate (accolate)
			Salbutamol (accuneb)	Hydrogen chloride quinapril (accupril)	Hydrochloric acid quinapril ﹠ hydrodiuril (accuretic)
Accutane (accutane)	Acebutolol(acebutolol)	Acebutolol (acebutolol?hydrochloride)
			Aceclofenac (aceclofenac)	Perindopril (aceon)	Acetaminophen (acephen)
Acetylcysteine injection (acetadote)	Acetaminophen (acetaminophen)	Acephenazine acetophenazine (acetaphenazine)
			Antipyrine salicylacetate (acetasol)	Acetazolamide (acetazolamide)	Acetazolamide that (acetazolamide sodium)
Acetic acid (acetic acid)	Acetohexamide (acetohexamide)	Acephenazine acetophenazine (acetophenazine)
			Acetylcysteine (acetylcysteine)	Lactulose (acilac)	RABEPRAZOLE SODIUM (aciphex)
Zoledronic acid (aclasta)	Aclovate (aclovate)	Rimonabant (acomplia)
			Corticorelin sheep trifluoracetic acid saline injection (acthrel)	Ursofalk (actigall)	γ-1b interferon (actimmune [interferon gamma-1b])
Citric acid fentanyl (actiq)	Alteplase [alteplase] (activase[alteplase])	Norethindrone (activella)
			Risedronic acid sodium tablet (actonel)	actoplus?met	Pioglitazone (actos)
Insulin zinc protamine (actraphane)	Like fast gene human insulin (actrapid)	actron
			Acular (acular)	acutect	Acyclovir (acyclovir)
Acycloguanosine sodium	Dapsone gel (aczone)	A Dagen (adagen)
			Visit new with (adalat cc)	The amfetamine salt mixture	Ademetionine

	(adderall)
			Adenosine (adenocard)	Diagnosis adenosine injection liquid (adenoscan)	Adenosine (adenosine)
Ah 's logical sequence azoles	adipex-p	Adrafinil
			Ah sewing Mi Xin (adriamycin pfs)	Fluorouracil (adrucil)	Shu Li is (advair) repeatedly
FLUTICASONE PROPIONATE (advair diskus)	The 8th thrombin (advate)	Nicotinic acid XR and lovastatin (advicor)
			Ibuprofen (advil)	En Lisi (aerius)	Adrenocortical hormone (aerobid)
Pseudoephedrine (afrinol)	Amprenavir (agenerase)	Amprenavir (aggrastat)
			Brain Kangping (aggrenox)	Anagrelide (Agrylin)	Ahnotriptan
External anabolic agent (a-hydrocort)	akbeta	Peace gram convulsion (Akineton)
			Akne-Mycin (akne-mycin)	akpentolate	Ai Gepu (Akpro)
Aktob	Hydrocortisone (ala-cort)	Histamine release inhibitors (Alamast)
			ala-scalp	alavert	Antazoline (albalon)
albenza	Radioactivity iodine-125 serum albumin (albumin iodinated i-125 serum)	Radioactivity iodine-131 serum albumin (albumin iodinated i-131 serum)
			Human albumin	Albuterol	Salbutamol sulfate
Ai Er caine (alcaine)	Two third Ah chlorine (alclometasone dipropionate)	Ethanol (alcohol)
			Aldactazide (aldactazide)	Aldosterone (aldactone)	Ida happy (aldara)
The general clean injection (aldesleukin) that stays	Methyldopa adds thiazine diuretic (aldoril)	Recombinant human alpha-L-iduronase (aldurazyme)
			Fosamax (alendronate)	Modafinil (alertec)	Levonorgestrel and ethinylestradiol (alesse)
Naproxen sodium (aleve)	alfentae	Alfentanil
			Fentanyl	Fentanyl	Alglucerase (alglucerase)
Alimta (alimta)	Nitazoxanide (alinia)	Alizapride
			Phe (alkeran)	allay	allegrae
allex	Allopurinol (Allopurinol	Allopurinol sodium
			Allylprodine	Alminoprofen	Almogran
Nedocromil Na (alocril)	A Lemai (alomide)	Allopurinol (aloprimm)
			Estradiol transdermal system (alora)	Palonosetron Hcl capsule (aloxi	Alpiropride (alperopride)
Ah method p (alphagan p)	Alphaprodine	alphatrex
			Alpidem	Alprazolam (alprazolam)	PGE1 (alprostadil)
alrex	alseroxlon	Ramipril (altace)
			altoprev	Lark good (alupent)	Ciclesonide (alvesco)
Diamantane (obsolete)	The hydrochloric acid diamantane (obsolete)	Ya Moli (amaryl)
			Hydrocodone (ambenyl)	An Bien (ambien)	The hepatitis A hepatitis B vaccine

		(ambirix)
			Ambisome (ambisome)	An Beishengtan (ambrisentan)	Amcinonide (amcinonide)
Naratriptan (merge)	Amesergide (amesergide)	Ya Meitailong (a-methapred)
			Amfenac (amfenac)	Aminocaproic acid (amicar)	A Midate(amidate)
Amifostine (amifostine)	Amikacin (amikacin)	Amikacin sulphuric acid
			Amikacin (amikin)	Amiloride hydrochloride (amiloride hydrochloride)	Aminoacid
Glycine	Aminocaproic acid	Sodium aminohippurate
			Aminophylline	4-[2-(dimethylamino)propionamido	aminosyn
Amiodarone (amiodarone)	Amiodarone Hydrochloride	Amiodarone hydrochloric acid
			Amisulpride (amisulpride)	Amitriptyline	Amitriptyline hydrochloric acid
Amixetrine (amixetrine)	Amlexanox (amlexanox	Amlodipine (amlodipine
			Amlodipine Besylate Tablet	Phenylbutyrate sodium (ammonaps	Ammonium chloride
DL-Lactic acid ammonium salt. (ammonium lactate)	Sodium benzoate and sodium phenylacetate (Ammonul)	Melissane (amnesteem)
			Amoxapine (Amoxapine)	Amoxicillin (Amoxicillin)	Amoxicillin (Amoxil)
Amperozide (Amperozide)	Cattle type hyaluronidase (Amphadase	Amphenidone (Amphenidone)
			Amphetamine	Amphotericin B (ampho b	Amphotericin B (ampho b)
Amphotericin b for inj B liposome (amphotec)	Solubility amphotericin B (amphotericin b)	Ampicillin (ampicillin)
			Ampicillin and sulfoxide penicillin	Sodium ampicillin	Sodium ampicillin/sulfoxide penicillin sodium
Ampicillin three water acid (ampicillin trihydrate)	Ampicillin/sulfoxide penicillium sp	Amrinone lactate (amrinone lactate)
			Amyl penicillin (amylpenicillin)	Adroyd (anadrol-50)	Clomipramine (anafranil)
Anagrelide hydrochloride (anagrelide hydrochloride)	anagryd	Nilutamide (anandron)
			Naproxen sodium (anaprox)	Cefazolin sodium (ancef)	Flucytosine (ancobon)
Testosterone plaster (androderm)	Testosterone gel (androgel)	android
			andropinirole	an-dtpa	Succinylcholine (anectine)
Lignocaine (anestacon)	Wei Keding (anexsia)	Drospirenone angeliq
			Bivalirudin (angiomax)	angiox?inn	Anidulafungin (anidulafungin)
Anileridine (anileridine)	Anileridine	ansaid
			Cefradine (anspor)	an-sulfur?colloid	Antabuse (antabuse)
antara(micronized)	Antivert (antivert)	antizol
			Sulphinpyrazone (anturane)	Anusol (anusol hc)	anzemet
anzemete	Azapropazone (apazone)	aphthasol
			apidra	apo-cilazapril/hctz	apo-digoxin
apo-etidronate	apo-feno-super	apo-flecainide
			The injection apomorphine	apo-levetiracetam	apo-medroxy

?(Apokyn9)
			?apo-meloxicam	apo-methotrexate	apo-metoprolol?sr
?apo-midodrine	apo-mirtazapine	Apomorphine
			Apomorphine hydrochloric acid	apomorphinediacetate	apo-omeprazole
?apo-ondansetron	apo-oxcarbazepine	apo-ramipril
			?apo-ranitidine	apo-risperidone	apo-sumatriptan
?apo-topiramate	Hydralazine hydrochloride-Hydrochlorothiazide Tablet (Apresazide)	aprotinin?bovine
			An Pu Novi (aprovel)	Tipranavir capsule (aptivus)	aquamephyton
?aquasol?a	Chloroquine, aralen (aralen)	aramine
			?aranelle	Erythropoietin Epoetin alpha-mutant (aranesp)	Leflunomide (arava)
Aredia (aredia)	Hydrochloric acid minot (arestin)	arestin?microspheres
			Argatroban (argatroban)	Argatroban (argatroban)	arginine?hydrochloride
Donepezil hydrochloride sheet (Aricept)	Duloxetine hydrochloride (ariclaim)	Anastrozole (arimidex)
			?aristocort?a	An Naide (aristospan)	Polysaccharide sodium (arixtra)
Exemestane (aromasin)	arranon	arsenic?trioxide
			Wet gram difficult to understand. (Arthrotec)	Epinephrine (articaine hydrochloride)	Mesalazine slow releasing tablet (asacol)
?asmanex?twisthaler	Aspirin (aspirin)	Nitrogen salt acid (astelin)
			?astramorph?pf	Candesartan Cilexetil (atacand)	atarax
Atenolol (atenolol)	Lorazepam (ativan)	atracurium?besylate
			Doxycycline hydrochloride (atridox)	Atropine (atropen)	Atropine sulfate
Atropine sulfate (edrophonium chloride)	Different third holder (atrovent)	Different third holder (atrovent)
			Reorganization thrombin (atryn)	Dextrorotation methylphenidate (attenade)	Amoxicillin and clavulanic acid (augmentin)
?avagard	Tazarotene (avage)	avaglim
			Irbesartan hydrochlorothiazide (avalide)	Rosiglitazone maleate and metformin hydrochloric acid (avandamet)	Rosiglitazone maleate and glimepiride (avandaryl)
Rosiglitazone (avandia)	Irbesartan (avapro)	Bevacizumab (avastin)
			Moxifloxacin hydrochloride (avelox)	aventyl?hydrochloride	aviane-28
Morphine sulfate (avinza)	Retinoic acid (Avita)	avodart
			Multiple sclerosis therapy medicine interferon (avonex)	Almogran Fructus Mali pumilae (axert)	Nizatidine (axid)
?axura	Norethindrone (aygestin)	Azacitidine (azacitidine)
			Aztreonam (azactam)	Azacyclonol (azacyclonol)	Azathioprine tablet (azasan)
Azasetron (azasetron)	Azatadine	Azathioprine (azathioprine)

		fumarate)
			Bitolterol (bitolterol)	Bitolterol mesilate	Bivalirudin (bivalirudin)
Bleomycin injection sulphuric acid (blenoxane)	Bleomycin (bleomycin)	Sulfo-bleomycin (bleomycin sulfate)
			Sulphacetamide (Bleph)	Sulfacetamide (blephamide)	Timolol (blocadren)
Hydrochlorothiazide (bolusacplus)	Ibandronate (Bondenza)	Ibandronic acid injection (bondronat)
			Ibandronate (boniva)	Phendimetrazine (Bontril)	Ibandronate (bonviva)
Creotoxin (botox[botulinum toxin type a])	Branched-chain amino acid (branchamin)	Injection Urofollitropin (bravelle)
			breathtek?ubt	Terbutaline sulphate (brethine)	Bretylium tosylate (bretylium tosylate)
Esmolol (brevibloc)	Norethindrone and ethinylestradiol (brevicon)	Methohexital (brevital sodium)
			brian?care	Brimonidine tartrate (brimonidine tartrate)	Quadracycline (bristacycline)
Brofaromine (brofaromine)	bromfed-dm	Bromfenac sodium (bromfenac)
			Bromine isoamyl vinegar (bromisovalum)	Bromocriptine	Bromocriptine methanesulfonate (bromocriptine mesylate)
Bromopride (bromopride)	Bromperidol (bromperidol)	Brompheniramine (brompheniramine)
			Methanesulfonic acid brompheniramine (brompheniramine maleate)	broncho?saline	bronitin?mist
Brucine	bss	Acetyl aminophenol (bucet)
			Buclizine (buclizine)	Budesonide	Formoterol fumarate (formoterol fumarate)
1-tert-butyl-4,4-diphenylpiperidine. (budipine)	Bufexamac (bufexamac)	Bumetanide (bumetanide)
			Bumetanide (bumex)	Phenylbutyrate sodium (buphenyl)	Bupivacaine hydrochloride (bupivacaine hydrochloride)
Epinephrine (bupivacaine hydrochloride)	Bupivacaine hydrochloride (bupivacaine hydrochloride/epinephrine bitartrate)	Buprenorphine (buprenex)
			Testosterone (buprenorphine)	Hydrochloric acid testosterone (buprenorphine hydrochloride)	Hydrochloric acid testosterone/naloxone hydrochloric acid
Butyl propanoic acid (bupropion)	Salt acid butyl propanoic acid	Buramate (buramate)
			Busulfan (busilvex)	Buspirone (buspar)	Buspirone (buspirone)
Buspirone hydrochlorine	Busulfan (busulfan)	Four Busulfans (busulfex)
			Sodium sheet (butabarbital)	Butaclamol (butaclamol)	butal?compound
Acetaminophen and caffeine (butalbital)	butapap	Butaperazine (butaperazine)
			Butabarbital sodium (butisol sodium)	Cloth Tono coffee (butorphanol)	Tartaric acid Bu Tuonuo coffee

Butriptyline	Exenatide (byetta)	Cabergoline (cabergoline)
			Amlodipine and atorvastatin (caduet)	Liposomal doxorubicin (caelyx)	Caffeine citric acid (cafcit)
Ergotamine tartrate and caffeine (cafergot)	Caffeine	Caffeine citrate (caffeine citrate)
			Vinpocetine preparation (calan)	Calcitriol injection (calcijex)	Calcitonin (Calcimar)
Salmon calcitonin see calcimar (calcitonin, salmon)	Calitriol (calcitriol)	Calcium chloride (calcium chloride)
			Calcium disodium chelate (calcium disodium versenate)	Calcium gluconate (calcium gluconate)	?calcium-n-carboamoylaspartate
?calfactant	Camilla (camila)	?campath[alemtuzumab]
			Kemp La Er (campral)	Irinotecan (camptosar)	Mesalazine (canasa)
Caspofungin acetate (cancidas)	cannobinoids	Cantil (cantil)
			Capreomycin sulfate Capastat sulfate (capastat sulfate)	capital?and?codeine	?capitrol
Captopril (capoten)	Captopril and hydrochlorothiazide (capozide)	?cap-profen
			Capreomycin sulfate Capastat sulfate (capreomycin sulfate)	Antihistaminic (captodiamine)	Captopril (captopril) (captopril)
Capuride (capuride)	Fluorouracil cream (Carac)	Sucralfate (carafate)
			?carbaglu	Dicentrine	Carbachol artificial (carbastat)
Carbamazepine sustained-release (carbatrol)	carbcloral	Carbenicillin
			Carbidopa sheet (carbidopa)	Block left-handed many E (Carbilev)	Restrain quick ingot (carbinoxamine maleate)
Carbifene (carbiphene)	Carbocaine (carbocaine)	Carboplatin (Carboplatin)
			Carboprost tromethane (carboprost tromethamine)	Carbromal (carbromal)	The Buddhist nun blocks (cardene)
Cardene (cardene sr)	cardiogen-82	Excellent heart film clothing ingot (cardiolite)
			?cardioplegic	Diltiazem (cardizem)	Carclura (cardura)
Carfecillin (carfecillin)	Carindacillin	Suo Ma (carisoprodol)
			Carmol (carmol hc)	Chlormethine (Carmustine)	Levocarnitine (camitor)
Caroxazone	Carfenazine	Carpipramine
			Carprofen	Carteolol hydrochloride (carteolol hydrochloride)	Diltiazem (cartia xt)
Bicalutamide (casodex)	Caspofungin acetate (caspofungin)	Caspofungin acetate (caspofungin acetate)
			Caspofungin (caspofungin msd)	Diclofenac (cataflam)	Fall and protect suitable ingot (catapres)
Clonidine (cataprese)	Alteplase [alteplase] (cathflo activase [alteplase])	Alprostadil injection (caverject)

?cea-scan	Ceftibuten (cedax)	Lomustine lomustine (ceenu)
			Cefaclor (Cefaclor)	Cefadroxil (cefadroxil)	Cefazolin sodium
Cefazolin sodium	Cefepime hydrochloride (cefepime hydrochloride)	Cefoxitin (cefinetazole)
			Ceftizoxime (cefizox)	Cefmetazole	Cefoperazone (cefobid)
Cefotetan (cefotan)	Cefotaxime (cefotaxime)	Cefotaxime sodium (cefotaxime sodium)
			Cefoxitin	Cefoxitin sodium	Cefpodoxime Proxetil (cefpodoxime proxetil)
Cefprozil (cefprozil)	Ceftazidime (ceftazidime)	Ceftazidime sodium (ceftazidime sodium)
			Cefuroxime (ceftin)	Ceftizoxime sodium (ceftizoxime sodium)	Ceftriaxone sodium (ceftriaxone)
Ceftriaxone sodium (ceftriaxone sodium)	Cefuroxime (cefuroxime)	Cefuroxime axetil (cefuroxime axetil)
			Cefuroxime Sodium (cefuroxime sodium)	Cefprozil (cefzil)	Celecoxib (celebrex)
(celestone) betamethasone	Betamethasone Soluspan (celestone soluspan)	Citalopram hydrobromate (celexa)
			Mycophenolate (cellcept)	Celontin (celontin)	cenestin
Mupirocin ointment (centany)	Cephazolin II	Cephalexin
			Cefaloglycin	Cafalotin I	Cephalosporin c
Cephalosporin	Cefalotin (cephalotin)	Methoxy cephalosporin a
			Methoxy cephalosporin b	Methoxy cephalosporin c	The methoxy cephalosporin
?cepharin	Cefradine	PROTEIN C concentrating agents (ceprotin)
			Ceftazidime (ceptaz)	Fosphenytoin sodium (cerebyx)	β-Fructus Vitis viniferae cerebrosidase (ceredase)
?ceretec	Cerezyme (cerezyme)	Cericlnmine
			Daunorubicin (cerubidine)	Dinoprostone (cervidil)	Hydrocortisone (cetacort)
(cetamide) sulphacetamide	The quick film clothing ingot that drives	(Cetrorelix) antagonists of gonadotropin-releasing hormone
			(cetrotidecetrorelix) acetic acid injection	(champix) Wahlen Ni Kelin	(chemet) mercapto succinic acid
?chg?scrub	Child's ibuprofen	Child's cathartic (children ' s elixsure)
			Child's ibuprofen	Child's ibuprofen (children ' s motrin	Child's ibuprofen (children ' s motrin
The acetic acid (chirhostim) of the short pancreatic juice of people	Cloral betaine	Chloromycetin (chloramphenicol)
			Protophenicol (Proto). (chloramphenicol sodium succinate)	Hibitane glucose (chloraprep)	chlorascrub

Chlordiazepoxide	Gluconate hibitane chlorhexidine gluconate	Chlorphenamine chlorpromazine (chlorobutinpenicillin)
			Chloromycetin (chloromycetin)	Chloroprocaine hydrochloride (chloroprocaine hydrochloride)	Arechin (Polfa) (chloroquine phosphate)
Chlorothiazide (chlorothiazide)	6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazin-2-ylsodium 1,1-dioxide (chlorothiazide sodium)	Chlorphenamine
			Chlorpromazine	Chlorpromazine hydrochloride	Chlorpromazine hydrochloride (intensol)
Chlorpropamide (chlorpropamide)	Chlorprothixene	Chlorthalidone (chlorthalidone)
			Chlorpheniramine (chlor-trimeton)	Chlorzoxazone (chlorzoxazone)	Lactulose (cholac)
Choledyl (choledyl sa)	Cholestagel (cholestagel	Colestyramine (cholestyramine)
			choletec	Choline	Biligrafin (cholografin meglumine)
Chorionic-gonadotropin hormone (choriogonadotropin alfa)	Floss [hair] film promoting sexual gland hormone (chorionic gonadotropin)	Chlorizate chromium (chromic chloride)
			Chromium phosphate (chromic phosphate, p-32)	Sodium chromate (chromitope sodium)	Sharp scholar
Ring ketoamine (ciclopirox)	cida-stat	Cidofovir (cidofovir)
			cilazaprol	Cilostazol	Xerox's eyedrop (ciloxan) that relaxes
Cimetidine cimetidine (the safe stomach of cimetidine U.S.)	Cimetidine hydrochloride (cimetidine hydrochloride)	Cinchophen
			Cinmetacin	Cinnarizine	?cipralex
Cirazoline (cipramadol)	cipro	Compound ciprofloxacin/dexamethasone aural preparations (ciprodex)
			(ciprofloxacin) ciprofloxacin	Ciprofloxacin (ciprofloxacin hydrochloride)	The ciprofloxacin levofloxacin (ciprofloxacin, levofloxacin)
Cisatracurium besylate (cisatracurium besylate)	Cis-mdp	Cisplatin (cisplatin)
			Cis-pyro	Citalopram	Citalopram hydrobromate
Prilocaine (citanest)	2-chlorodeoxyadenosine (cladribine)	Cefotaxime (claforan)
			Isotretinoin-oral (claravis)	Desloratadine (clarinex)	Clarithromycin (clarithromycin)
Chlorine thunder (claritin)	Clebopride	Clemastine
			Clemastine fumarate	Clindamycin (cleocin)	The mould rope hydrochlorate of crin (cleocin hydrochloride)
Cleocin phosphate (cleocin phosphate)	The mould rope T of crin (cleocin t)	Estradiol (climara)
			clinda-derm	Clindamycin phosphate gel (clindagel)	Clindamycin (clindamycin)
Clindamycin hydrochloride	Clindamycin phosphate	?clinda-t

?(clindamycin ?hydrochloride)	?(clindamycin?phosphate)
			Clindamycin phosphate clindesse ()	?clindets	Ke Limisi (clinimix)
Sulphite does not have (aminoacid) injection (clinisol)	Sulindac (clinoril)	Clobenzepam
			Clobetasol propionate (clobetasol propionate)	Clobetasol propionate (clobex)	Clocapramine
Cloderm (cloderm)	?clofarabine	Chlorine Bei Te (clofibrate)
			Clolar (clofibrate)	Clomacran	Clometacin (clometacin)
Clometocillin (clometocillin)	Clomiphene (clomid)	Chloramiphene (clomiphene citrate)
			Clomipramine (clomipramine)	Hydiphen (clomipramine hydrochloride)	Clonazepam (clonazepam)
Clonidine	Dichloranilino imidazolin	Clonitazene (clonitazene)
			Clonixin (clonixin)	Clopenthixol (clopenthixol)	clopriac
Chlorine nitrogen dipotassium (clorazepate dipotassium)	Clorpres (clonidine hydrochloride and chlortalidone)	8-(clospirazine)
			Clotiapine (clothiapine)	Clotrimazole (clotrimazole)	Clovoxamine (clovoxamine)
Chlorine spills XiLin	Chlorine spills XiLin sodium	Cloxacillin (Cloxapen)
			Clozapine (clozapine)	Clozaril (clozapine)	Bicalutamide (co bicalutamide)
Inhibace (co cilazapril)	Fluconazole (co fluconazol)	co?fosinopril
			?co?ipra-sal	?co?risperidone	co?salbut-iprat?inhalation solution
Topiramate (co topiramate)	Can general Novi ingot (coaprovel)	Codeine
			Chlorphenamine maleate and codeine (codeprex)	Acetyl aminophenol/codeine (codrix)	Benzatropine (cogentin)
?co-gesic	Tacrine (cognex)	co-lav
			Balsalazide sodium (colazal)	Colestipol (colestid)	colgate
?colistimethate	Colistimethate sodium (colistimethate) sodium	colocort
			Compound formulation probenecid-colchicine (col-probenecid)	Polymyxin E (coly-mycin m)	coly-mycin?s
Polyethylene glycol electrolyte solution (colyte)	Estradiol, norethindrone acetate transdermal patch (combipatch)	Combivent (Combivent)
			The card shellfish grows (combivir)	Oxycodone hydrochloride and ibuprofen (combunox)	Promise to undertake buccal tablet (commit)
Compazine (compazine)	Metformin and pioglitazone hydrochloride (competact)	compro
			Entacapone (Comtan)	?comtess	Methylphenidate slow releasing tablet (concerta)
?concertae	?condylox	Hydrochloric acid conivaptan (conivaptan

		hydrochloride)
			conray	Cephulac (constilac)	Lactulose (constulose)
copasys?copegus [peginterferon?alfa-2a]	Can relaxed and comfortable (copaxone)	Ribavirin (copegus)
			Copper (copper)	Amiodarone Hydrochloride sheet (cordarone)	Flurandrenolide (cordran)
Carvedilol (coreg)	Nadolol ingot (corgard)	corlentor
			Fenoldopam methanesulfonic acid (corlopam)	?cormax	Pseudoephedrine hydrochloride (corphed)
Hydrocortisone (cortef)	Cortenema (hydrocortisone)	Trifluoroacetate corticorelin (corticorelin ovine triflutate)
			Adrenocorticotropin releasing hormone (corticotropin)	Hydrocortisone acetate (cortifoam)	Hydrocortisone acetate (cortifoam, hydrocortisone acetate)
Cortisone acetate (cortisone acetate)	?cortisporin	Thyroliberin (cortrosyn)
			Ibutilide fumarate injection (corvert)	Nadolol and bendroflumethiazide tablet (corzide)	Sertraline (co-sertraline)
Dactinomycin (cosmegen)	Compound maleic acid timolol/dorzolamide hydrochloride eye drop (cosopt)	Tetracosactide (cosyntropin)
			But ferrum peaceful (cotinine)	Sulfamethoxazole and trimethoprim (cotrim)	cotronak
Warfarin (coumadin)	?covera-hs	Perindopril (coversyl)
			Section's element (cozaar)	Rosuvastain calcium (crestor)	crinone
Indinavir sulfate (crixivan)	4% sodium cromoglicate solution (crolom)	Sodium cromoglicate
			Crotamiton (crotan)	Ethinylestradiol methylnorethindron (cryselle)	c-solve-2
Daptomycin (cubicin)	Copper chloride (cupric chloride)	Penicillamine (cuprimine)
			Curosurf Gu Er Soviet Union	Fluticasone propionate emulsifiable paste (cutivate)	Cyamemazine (cyamemazine)
Vitamin B12 (cyanocobalamin)	Cyclacillin (cyclacillin)	Desogestrel ethinylestradiol sheet (cyclessa)
			Cyclizine	Cyclobenzaprine (cyclobenzaprine)	Chlorination cyclobenzaprine (cyclobenzaprine hydrochloride)
Cyclocort (cyclocort)	Cyclopentolate hydrochloride (cyclogyl)	Danazol (cyclomen)
			The bright collyrium of mydriasis (cyclomydril)	Cyclopentolate (cyclopentolate hydrochloride)	Cyclophosphamide (cyclophosphamide)
(cyclosporin a) for ciclosporin	Cyclosporin (cyclosporine)	Tranexamic acid (cyklokapron)
			Duloxetine (cymbflta)	Cyproheptadine	Cyproheptadine hydrochloride
Anhydrous betaine (cystadane)	Cysteamine tartaric acid (cystagon)	cysto-conray?ii

?cystografin	?cystografin?dilute	Aminoglutethimide (cytadren)
			Cytosine arabinoside (cytarabine)	?cytomegalovirus?immune ?globulin(cmv-igiv)	cytomel
Cytosar (cytosar-u)	Misoprostol (cytotec)	(cytovene iv) for Cymevene
			Cyclophosphamide (cytoxan)	Dihydroergotamine (d.h.e.45)	Dacarbazine (dacarbazine)
Actinomycin D (dactinomycin)	Flurazepam (dalmane)	Dalteparin sodium (dalteparin sodium)
			Danazol (danazol)	Dantamacrin injection (dantrium)	Dantrolene sodium (dantrolene sodium)
Dapsone (dapsone)	Daptomycin (daptomycin)	Pramipexole (daquiran)
			Pyrimethamine (daraprim)	A Fadabei Bo Ting (darbepoetin alfa)	darvocet
Regretol (darvon)	?datscan	Daunorubicin (daunorubicin citrate)
			Zorubicin hydrochloride (daunorubicin hydrochloride)	Liposome daunorubicin (daunoxome)	Oxaprozin (daypro)
Desmopressin (ddavp)	?ddavp?melt	Decadron (decadron)
			(declomycin) declomycins	Deferoxamine mesylate (deferoxamine mesylate)	Perfluoropropane (definity)
Testosterone enanthatas (delatestryl)	Estradiol valerate (delestrogen)	delflex
			Alleviated cough slow release suspendible Fructus Citri tangerinae flavor liquid (delsym) in 12 hours	Torasemide (demadex)	Demethylchlortetracyclini chloridum (demeclocycline hydrochloride)
Pethidine (demerol)	Metirosine (demser)	Ethynodiol diacetate (demulen)
			Penciclovir (denavir)	Iodouracil desoxyriboside (dendrid)	Sodium valproate (depacon)
Valproic acid (depakene)	Sodium valproate (depakote)	Penicillamine (depen)
			Liposome cytosine arabinoside (depocyt)	Depocyte liposome cytosine arabinoside	Morphine sulfate time-delay lipid release body injection (depodur)
Estradiol cypionate (depo-estradiol)	Acetic acid 6-methylprednisolone (depo-medrol)	Medroxyprogesterone acetate (depo-provera)
			Medroxyprogesterone acetate suspensoid injectio (depo-subq provera 104)	Depo-testosterone (depo-testosterone)	Deprenalin see selegiline (deprenyl)
?dermabet	?derma-smoothe/fs	Prednicarbate emulsifiable paste (dermatop)
			Deferoxamine mesylate (desferal)	Desflurane (desflurane)	Desipramine (desipramine)
Hydrochloric acid desipramine (desipramine hydrochloride)	Desirudin reorganization thing (desirudin recombinant)	Desmopressin acetate (desmopressin acetate)
			Desogen (desogen)	Desogestrel (desogestrel)	Ground Suo Naide (desonide)
Desonide emulsifiable paste (desowen)	Desoximetasone (desoximetasone)	Desoxyephedrine hydrochloride (desoxyn)
			Desyrel (desyrel)	The tolterodine tartrate tablet	Dexamethasone (dexamethasone)

	(detrol)
			Dexamethasone (dexamethasone)	Dexamethasone (dexamethasone intensol)	Dexamethasone sodium phosphate
dexasporin	Dexbrompheniramine maleate (dexchlorpheniramine maleate)	Dextroamphetamine (Dexedrine)
			Dexfenfluramine (dexfenfluramine)	Iron dextran (dexferrum)	Dexmedetomidine hydrochloride (dexmedetomidine)
Dexrazoxane (dexrazoxane) (dexrazoxane)	Hydrochloric acid dexrazoxane (dexrazoxane hydrochloride)	?dextroamp?saccharate
			Dexamphetamine	Dexamphetamine sulphuric acid	Dextromoramide (dextromoramide)
Propoxyphene	Glucose, dextrose (dextrose)	DAS and tartrazines tablet (dextrostat)
			Glibenclamide (diabeta)	Chlorpropamide (diabinese)	?dialyte
dialyte?concentrate	Heroin	Acetazolamide (diamox)
			Peritoneal dialysis solution (dianeal)	Diazepam (diastat)	Diastat (diastat acudial)
Meglucamine diatrizoate (diatrizoate meglumine)	Sodium amidotrizoate (diatrizoate sodium)	Stable
			Stable (intensol)	Diazoxide (diazoxide)	Phenoxybenzamine (dibenzyline)
Diclofenac (diclofenac)	Dichloro spills XiLin	Dichloro spills XiLin sodium
			Bentrl hydrothloride (dicyclomine hydrochloride)	Didanosine (didanosine)	Benzfetamine hydrochloride (didrex)
Etidronate (didronel)	Da Fuwen (differin)	Diflorasone diacetate (diflorasone diacetate)
			Fluconazol (diflucan)	Diflunisal (diflunisal)	Digoxin (digoxin)
Paracodin	The dihydro Ergokryptine	Dihydroergotamine
			Dihydroergotamine (mesylate)	Diltiazem (dilacor)	Dilantin (phenytoin Sodium)
Sorbide nitrate (dilatrate-sr)	Dilauid (dilaudid)	Dihydroxypropyltheo-pylline (dilor)
			dilt-cd	Diltiazem (diltiazem)	Diltiazem hydrochloride (diltiazem hydrochloride)
Dimenhydrinate (dimenhydrinate)	Dimercaprol (Dimercaprol)	Dimethyl sulfoxide (dimethyl sulfoxide)
			Valsartan (diovan)	Olsalazine sodium (dipentum)	Diphenhydramine (diphenhydramine)
Diphhydramine hydrochloride (diphenhydramine hydrochloride)	Diphenicillin (diphenicillin)	Diphenidol (diphenidol)
			Diphenoxylate	Dipipanone (dipipanone)	Dipivefrin hydrochloride (dipivefrin hydrochloride)
Diprivan (diprivan)	Betamethasone (diprolene)	Persantin (dipyridamole)
			Pseudoephedrine (disophrol)	The phosphoric acid disopyramide	Amoxicillin (dispermox)

	(disopyramide?phosphate)
			Disulfiram (disulfiram)	Oxibutynin (ditropan)	Chlorothiazide-reserpine (diupres)
Chlorothiazide (diuril)	Dobutamine hydrochloride (dobutamine hydrochloride)	Dobutamine hydrochloride (dobutrex)
			Docetaxel (docetaxel)	One water beetle sulfonic acid dolasetron (dolasetron mesylate monohydrate)	Dolasetron methanesulfonates (dolasetronmethanesulfonate)
Diflunisal (dolobid)	Methadone hydrochloride (dolophine hydrochloride)	Alendronate (dom-alendronate)
			Anagrelide (dom-anagrelide)	Bicalutamide (dom-bicalutamide)	Citalopram (dom-citalopram)
Doxycycline (dom-doxycycline)	domeridone	Hydrodiuril (dom-hydrochlorothiazide)
			Mirtazapine (dom-mirtazapine)	dom-ondanssetron	Risperidone (dom-risperidone)
?dom-simvastatin	Ursodesoxycholic acid (dom-ursodiol c)	Dopamine hydrochloride (dopamine hydrochloride)
			Dopram (doxapram)	doral	A-deoxyribonuclease (dornase alfa)
Doryx (doxycycline hydrochloride)	Cabergoline (dostinex)	Dosulepin (dosulepin)
			Calcipotriol (dovonex)	doxacalciferol	Doxapram hydrochloride (doxapram hydrochloride)
Carclura (doxazosin mesylate)	Doxepin	Doxepin hydrochloric acid
			Hydrochloric doxorubicin liposome (doxil)	Amycin	Amycin hydrochloric acid
Doxycycline (Doxy)	Doxycycline (doxycycline)	Sea gram sour doxycycline (doxycycline hyclate)
			Doxylamine (doxylamine)	Decapryn succinage (doxylamine succinate)	draximage?mdp
?dricort	Vitamin D2 (drisdol)	drixoral
			Dronabinol (dronabinol)	Droperidol (droperidol)	droprenilamin?hcl
?droxia	Dacarbazine (dtic-dome)	Diethylene triamine pentacetic acid (DTPA) (dtpa)
			External-use gel (duac)	Oral cholera vaccine (dukoral)	Duloxetine (duloxetine)
?duo?trav	duocaine	Ipratropium bromide and salbutamol sulfate (duoneb)
			?duotrav	Clonidine injection (duraclon)	Fentanyl transdermal (duragesic)
?duragesic?mat	Injection of morphia liquid (duramorph)	Cefadroxil (duricef)
			Bethanechol chloride (duvoid)	Triamterene (dyazide, hydrochlorothiazide)	Minocycline (dynacin)
Isradipine (dynacirc)	dyna-hex	Parecoxib (dynastat)

Erythropoietin (dynepo)	Phenalgin (dyrenium)	Erythromycin ethylsuccinate (erythromycin ethylsuccinate)
			?e-base	ebixa	Naproxen (ec-naprosyn)
Econazole nitrate (econazole nitrate)	Prednisolone acetate (econopred)	Sharp acid (edecrin)
			Disodium calcium edetate (edetate calcium disodium)	Disodiumedetate (edetate disodium)	Alprostadil injection (edex)
Edrophonium chloride (edrophonium chloride)	Venlafaxine (effexor)	Pseudoephedrine (Efidac)
			Fluorouracil (efudex)	e-glades	SelegilineHydrochloride sheet (eldepryl)
Epinastine (elestat)	Eletriptan (Eletriptan)	Skin is readily taken the opportunity to (elidel)
			Leuprorelin acetate acetic acid (eligard)	Permethrin (elimite)	Glutamic acid (eliprodil)
Rasburicase (elitek [rasburicase])	Potassium iodide (Elixophyllin)	Ellence (epirubicin hydrochlorate)
			Dust Leo solution (elliotts b solution)	Like to secrete sieve (elmiron) (	Mometasone (elocon)
Oxaliplatin injection (eloxatin)	L-asparaginase (elspar [asparaginase])	Fumaric acid emedastine eye drop (emadine)
			Clobetasol (embeline)	Estramustine phosphate (emcyt)	Aprepitant capsule (emend)
Hydrochloric acid Benzquinamide (emete-con)	En Na (emla)	Darifenacin hydrobromide (emselex)
			Emtricitabine (emtriva)	Moldin (e-mycin)	Tenidap (enablex)
Enalapril (enalapril)	Maleic acid Enalapril (enalapril maleate)	Enalaprilat (enalaprilat)
			Embrel (enbrel)	Enciprazine (enciprazine)	Sodium bicarbonate (endosol)
Two sodium injections (endrate)	Methyclothiazide (enduron)	Enflurane
			En Fuwei ground (enfuvirtide)	Edrophonium chloride (enlon)	Enoxaparin Sodium (enoxaparin sodium)
?enpresse-28	Entacapone (entacapone)	Budesonide (entocort)
			An Taole (entonox)	Lactulose (enulose)	Ephedrine
Hydrocortisone acetate (epifoam)	Epinephrine	Epinephrine (epipen)
			Epirubicin hydrochloride (epirubicin hydrochloride)	Carbamazepine (epitol)	Lamivudine (epivir)
A-erythropoietin (epoetin alfa (procrit))	Erythropoietin (epogen [epoetin alfa])	Cycloprostin (epoprostenol sodium)
			Eptastigmine (eptastigmine)	Eptifibatide (eptifibatide)	Abacavir sulfate and lamivudine (epzicom)
?equagesic	Carbamazepine (equetro)	Erbitux (erbitux)
			?ergolinepramipexole	Dihydroergotoxine methanesulfonate (ergoloid mesylates)	Ergotamine (ergomar)
Ergotamine	Gynergen	Erbitux (eribitux[cetuximab])
			?errin	ertaczo	Ertapenem (ertapenem sodium)
Roxithromycin (eryc)	2% erythromycin (erycette)	Erythromycin (eryderm)

Erygel (erythromycin external-use gel)	Erythromycin ethylsuccinate (eryped)	Erythromycin (ery-tab)
			?erythra-derm	Erythromycin lactobionate (erythrocin)	Erythromycin octadecanoate (erythrocin stearate)
Erythromycin (erythromycin)	Propionic ester Laurel sulphuric acid Abboticine (erythromycin estolate)	Erythromycin ethylsuccinate (erythromycin ethylsuccinate)
			Erythromycin lactobionate (erythromycin lactobionate)	Stearic acid Abboticine (erythromycin stearate)	eryzole
?esgic-plus	Hydrochlorothiazide (esidrix)	Lithium carbonate (eskalith)
			Esmolol hydrochloride (esmolol hydrochloride)	?e-solve?2	Esomeprazole sodium (esomeprazole sodium)
Estazolam (estazolam)	Estradiol (estrace)	Estradiol transdermal (estraderm)
			Estradiol (estradiol)	Estradiol Cypionate (estradiol cypionate)	Estradiol valerate (estradiol valerate)
Estradiol (estrasorb)	Estradiol pessary (estring)	Estradilum (estrogel)
			Conjugated estrogen (estrogens, conjugated)	Estrone (estrone)	Estropipate (estropipate)
Estradiol norethindrone acetate (estrostep fe)	Dietamiphylline (etamiphyllin)	Etaqualone (etaqualone)
			Sodium etacrynate (ethacrynate sodium)	Ethambutol	Ethambutol hydrochloric acid
Ethanolamine oleic acid (ethamolin)	EO (ethanolamine oleate)	Ethiodized Oil (ethiodol)
			Moracizine (ethmozine)	Wy-401 (ethoheptazine)	Ethosuximide (ethosuximide)
Enflurane (ethrane)	Amifostine (ethyol)	Etidronate disodium (etidronate disodium)
			Etodolac (etodolac)	Etomidate (etomidate)	Etoposide phosphate (etopophos)
Etoposide (etoposide)	Phosphoric acid etoposide (etoposide phosphate)	Flutamide (eulexin)
			Crotamiton frost (eurax)	Lactulose (evalose)	RALOXIFENE HCL (evista)
?evocline	?evoltra	Cevimeline (evoxac)
			?evra	Ai Kesaidelin (excedrin)	Sulconazole Nitrate (exelderm)
Exelon (exelon)	Yi Kena peptide (exenatide synthetic)	Hibitane (exidine)
			?exjade	The solvable ingot of Xie Tie (exjade)	Neonate Colfosceril Palmitate (exosurf neonatal)
The phenytoin Sodium (extended phenytoin sodium) of continuity	IDALL's Neil (extraneal)	extra-strength?aim
			Induction type insulin (exubera)	?e-zprep	Ezetimibe (ezetrol)
The Fa Burui enzyme freezes crystalline substance (fabrazyme)	Factive (factive)	The 9th coagulation factors complex (factor ix complex (konyne 80,

		profilnine?heat-treated，proplex sx-t，proplex-t))
			?factor?vii(novoseven， ?niastase)	Factor antibody (factor viii (alphanate, hemofil m, humate-p, koate-hp, koate-hs, monoclate-p))	factor?xi(hemoleven，factor?xi concentrate[bpl])
Famotidine (famotidine)	Famciclovir (famvir)	Sulfanilamide and pyrimethamine (fansidar)
			Toremifene Citrate (fareston)	Fulvestrant (faslodex)	Reorganization urate oxidase (fasturtec)
Leponex orally speed disintegrating tablet (fazaclo odt)	Non-ammonia ester (felbatol)	Piroxicam (feldene)
			Felodipine (felodipine)	Letrozole sheet (femara)	Norethindrone acetic acid, ethinylestradiol (femhrt)
Estradiol acetic acid (femring)	Nitric acid butoconazole (femstat 3)	Estradiol acetate (femtrace)
			Hepatitis B vaccine (fendrix)	Fenfluramine	Fenofibrate (fenofibrate)
Methanesulfonic acid Fenoldopam (fenoldopam mesylate)	Fenofibrate (fenomax)	Fenopron (fenoprofen calcium)
			Sweet smell is the slave too	Sweet smell is slave's citric acid too	Luxuriant and rich with fragrance upright magnetic (feridex i.v.)
Deferiprone sheet (ferriprox)	Gluconic acid ferrum sodium (ferrlecit)	Ferrum oxide (ferumoxides)
			Fexofenadine (fexofenadine)	Fexofenadine hydrochloride (fexofenadine hydrochloride)	fientanyl
Filgrastim (filgrastim (neupogen))	Azelaic Acid (finacea)	fioricet
			?fiorinal	Metronidazole (flagyl)	flagystatin
Stroke inflammation (flarex)	Flavoxate hydrochloride (flavoxate hydrochloride)	Flecainide acetate (flecainide acetate)
			The fluorine gram is given birth to (flesinoxan)	Cyclobenzaprine hydrochloride (flexeril)	Cycloprostin (flolan)
Tamsulosin hydrochloric acid (flomax)	Fluticasone propionate nasal spray (flonase)	Fludrocortisone (florinef)
			Diflorasone diacetate (florone)	Fluticasone (flovent)	Fluticasone propionate inhalation aerosol (flovent hfa)
Ofloxacin (floxin)	Fluconazol (fluconazole)	Fluconazol (fluconazole)
			Fludarabine (fludara)	Fludarabine phosphate (fludarabine phosphate)	Deoxy-glucose (fludeoxyglucose)
Deoxy-glucose (f-18fludeoxyglucosef-18)	Acetic acid fludrocortisone (fludrocortisone acetate)	Rimantadine (flumadine)
			Flumazenil (flumazenil)	Flunisolide (flunisolide)	Fluocinolone acetonide (fluocinolone acetonide)
Fluocinolone acetonide (fluocinonide)	Fluor-Op (fluor-op)	Fluorouracil (fluoroplex)
			Fluorouracil (fluorouracil)	fluotic	Fluoxetine Hydrochloride (fluoxetine)
Fluoxetine Hydrochloride (fluoxetine	Fluoxymesterone	Flupenthixol (flupenthixol)

hydrochloride)	(fluoxymesterone)
			Fluphenazine	Fluphenazine (decanoate)	Fluphenazine hydrochloric acid
Flupirtine (flupirtine)	Flurazepam	Flurazepam hydrochloride
			Flurbiprofen (flurbiprofen)	Flurbiprofen sodium (flurbiprofen sodium)	Fluspirilene (fluspirilene)
Flutamide (flutamide)	Fluticasone	Fluvoxamine (fluvoxamine)
			Fluvoxamine maleate (fluvoxamine maleate)	fluxid	fml
foamcoat	Methylphenidate (focalin)	Folic acid (folic acid)
			The Hu Mie (folicet) that falls	The plain β (follistim aq) of follicle	Follitropin (follitropin alfa/beta)
Injection fomepizole (fomepizole)	Sulphur reaches liver sodium in the last of the ten Heavenly stems (fondaparinux sodium)	Formoterol (foradil)
			Isoflurane (forane)	Salmon calcitonin see calcimar (forcaltonin)	Fumaric acid formoterol (formoterol fumarate)
Teriparatide (forsteo)	fortamete	Ceftazidime (fortaz)
			Teriparatide (forteo)	Calcitonin (fortical)	Saquinavir mesilate (fortovase)
Alendronate sodium (fosamax)	Alendronate sodium (fosavance)	foscan
			Foscarnet sodium (foscarnet sodium)	Foscavir (foscavir)	Fosinopril sodium (fosinopril)
Fosinopril sodium (fosinopril sodium)	Fosphenytoin sodium (fosphenytoin sodium)	Lanthanum carbonate (fosrenol)
			Dalteparin sodium injection (fragmin)	Fraxiparine injection (fraxiparine and fraxiparine forte)	Aminoacid-injection (freamine)
Fluorine cuts down Qu Tan (frova)	Frova (frovatriptan)	fs?shampoo
			5-fluoro-2 '-deoxidation urea nucleoside (fudr)	Estrogen receptor antagon (fulvestrant)	Grysio (u/ffulvicin-u/f)
Amphotericin B (fungizone)	Nitrofurantoin (furadantin)	Furosemide (furosemide)
			Good fortune Chinese mugwort injection (fuzeon)	Gabapentin (gabapentin)	Tiagabine (gabitril)
Gadobenate dimeglumine (gadobenate dimeglumine)	Liposome (gadodiamide)	Gadobenate dimeglumine (gadopentetate dimeglumine)
			Gadoteridol (gadoteridol)	Gadoversetamide (gadoversetamide)	Galantamine (galanthamine)
Gallium citrate (gallium citrate ga 67)	Ganite (Fujisawa). (gallium nitrate)	Zinc acetate (galzin)
			Ganciclovir (ganciclovir)	Lip river sodium of sweet former times (ganciclovir sodium)	ganfort
Ganirelix acetate (ganirelix acetate)	Ganite (Fujisawa). (ganite)	The sulfanilamide of department of pediatrics different (gantrisin pediatric)
			Human papilloma virus's vaccine (gardasil)	Gastrocrom (gastrocrom)	Stomach adds fragrant liquid (gastrografin)
Transparent yellow iron oxide (gastromark)	Mesalazine (gaviscon)	Amlodipine (gd-amlodipine)

Atorvastatin (gd-atorvastatin)	Azithromycin (gd-azithromycin)	Fluconazole (gd-fluconazole)
			Gadolinium atorvastatin (gd-gabapentin)	?gd-gemfibrozil	Sertraline (gd-sertraline)
Gemcitabine hydrochloride (gemcitabine hydrochloride)	Gemfibrozil (gemfibrozil)	Gemtuzumab (gemtuzumab ozofamicin)
			Gemcitabine hydrochloric acid (gemzar)	Gen Alun (gen-alendronate)	Azithromycin (gen-azithromycin)
?gencept	Inhibace (gen-cilazapril)	Domperidone (gen-domperidone)
			?generlac	Root cilazapril (gen-glimepiride)	Ciclosporin (gengraf)
Meloxicam (gen-meloxicam)	Gen Lipei (genoptic)	Growth hormone (genotropin)
			Pravastatin (gen-pravastatin)	Risperdal (gen-risperidone)	Gentamycin (gentacidin)
Gentak (gentak)	Gentamycin (gentamicin)	Sulfo-gentamycin (gentamicin sulfate)
			Warfarin (gen-warfarin)	?gen-xene	Carbenicillin indanyl sodium (geocillin)
Ziprasidone hydrochloride (geodon)	Gepirone (gepirone)	Sermorelin acetate (geref)
			?gerimal	Auxin (ghrelin)	Imatinib mesylate (gleevec)
Gliadel (gliadel)	Gliclazide (gliclazide)	Glimepiride (glimepiride)
			Glipizide (glipizide)	Imatinib mesylate (glivec)	glofil-125
Glucagon (glucagen)	Glucagon (glucagons)	Acarbose (glucobay)
			Metformin hydrochloride (glucophage)	Glipizide controlled release tablets (glucotrol)	Glucosamine sulfate (glucovance)
Diabecron sustained-release tablet (glumetza)	Pioglitazone (glustin)	Glutathion
			Glibenclamide (glyburide)	Glycine (glycine)	glycolax
Robinul (glycopyrrolate)	Glibenclamide (glynase)	Miglitol (glyset)
			Azithromycin (gmd-azithromycin)	Sertraline (gmd-sertraline)	go-evac
Polyethylene Glycol 3350 and electrolyte oral liquid (golytely)	The promoting sexual gland hormone of floss [hair] film (gonadotropic, chorionic)	gonal-f
			Granisetron Hydrochloride capsule (granisetron)	Granisetron Hydrochloride (granisetron hydrochloride)	(grifulvin v) for griseofulvin
Griseofulvin (griseofulvin)	?gris-peg	Growth hormone (growth hormone)
			4-imidazoleacetic acid hydrochlorate (guanabenz acetate)	Guanfacine Hydrochloride (guanfacine hydrochloride)	Guanidine hydrochloride (guanidine hydrochloride)
Nitric acid butoconazole vaginal cream (gynazole-1)	?gyne-lotrimin	gynix

gynodiol	h.p.acthar?gel	Nicotine (Habitrol)
			Triazolam (halcion)	Halopeidol inj (haldol)	halflytely
Halobetasol Propionate (halobetasol propionate)	Halcinonide (halog)	Haloperidol
			Haloperidol (decanoate)	The lactic acid haloperidol	haloperidole
Fluoxetine (halotestin)	Halothane	hbvaxpro
			hectorol	Helicobacter pylori test (helicobacter test infai)	helidac
Helium-oxygen gas mixture	helixate?nexgen	Glad nurse abundant (hemabate)
			Recombinant hepatitis B vaccine (hepacare)	Heparin injection (heparin lock flush)	Heparin sodium (heparin sodium)
Liver ammonia injection (hepatamine)	hepatasol	Hepatitis B immunoglobulin (hepatitis b immune globulin (bayhep b, hepagam b))
			hepatolite	hepflush-10	hep-lock
Adefovir ester (hepsera)	Lactulose (heptalac)	Penicillin K (heptylpenicillin)
			Trastuzumab (herceptin)	Herplex (herplex)	Hetacillin (hetacillin)
AG-6227 (hexabrix)	Dexamethasone (hexadrol)	Hexalen (hexalen)
			Six directions vaccine (hexavac)	Gluconic acid chlorine (hibiclens)	Chlorhexidine gluconate (hibistat)
hi-cor	Hexamethylenamine derivant (hiprex)	Zalcitabine (hivid)
			hms	homatroprine methylbromide	Insulin lispro (humalog)
humaspect	Paromomycin (humatin)	Paromomycin (humatrope)
			Adalimumab (humira)	Excellently secrete woods (humulin)	Antineoplastic agent (hycamtin)
Dihydrocodeinone (hycodan)	Hyaluronidase injection (hydase)	Hydergine (hydergine)
			Hydralazine hydrochloride (hydralazine hydrochloride)	Acid hydrazide (hydra-zide)	Hydroxyurea (hydrea)
Hydrocet (hydrocet)	Hydrochlorothiazide (hydrochlorothiazide)	Dihydrocodeinone bitartrate (hydrocodone bitartrate)
			Hydrocortisone (hydrocortisone)	Hydrocortisone sodium succinate (hydrocortisone sodium succinate)	Hydroflumethiazide (hydroflumethiazide)
Dihydroergotoxin (hydrogenated ergot alkaloids)	Hydromorphone (hydromorphone)	Dihydromorphinone hydrochloride (hydromorphone hydrochloride)
			hydro-ride	Vitamin B12 (hydroxocobalamin)	Hydroxychloroquine sulfate (hydroxychloroquine sulfate)
Hydroxyurea (hydroxyurea)	Hydroxyzine	Hydroxyzine hydrochloric acid
			Hydroxyzine (pamoate)	Reorganization hyaluronidase (hylenex recombinant)	Scopolamine

Thypaque sodium (hypaque)	The oral powder of thypaque sodium (hypaque oral powder)	Diazoxide (hyperstat)
			Hydrocodone (hy-phen)	Hydrocortisone (hytone)	Terazosin hydrochloric acid (hytrin)
Hyzaar (hyzaar)	Ibandronate (ibandronate)	ibandronic?acid?roche
			Ibuprofen (ibu)	Ibuprofen	Ibuprofen lysinate (neoprofen)
Ibuprofen (ibuprohm)	Fumaric acid ibutilide (ibutilide fumarate)	ic-green
			Darubicin (idamycin pfs)	Hydrochloric acid idarubicin (idarubicin hydrochloride)	Idazoxan (idazoxan)
ifex/mesnex?kit	Ifosfamide (ifosfamide)	(iletin ii) for Insulinum
			Iloprost	Isosorbide mononitrate (imdur)	Imiglucerase (imiglucerase)
imipenem/cilastatin， meropenem，ertapenem	Imipramine	Imipramine HCl
			Sumatriptan succinate Qu Tan (imitrex)	Immunoglobulin immune globulin (baygam, vivaglobin)	Imodium (imodium)
The peace of should sleeping (imovane)	According to Drymotaenium miyoshianum (Mak.) Mak. (imuran)	Amrinone lactate (inamrinone lactate)
			Fluorine piperidines (inapsine)	increlex	Indapamide (indapamide)
Droperidol (inderal la)	Enalapril (inderide)	indiclor
			Indium sesquioxide. (indium)	Indium chloride (indium in 111 chloride)	indium?in?111?oxyquinoline
indium?in?111?pentetate disodium	Indium [111In] pentetreotide injection (indium in 111 pentetreotide)	Indometacin (indocin)
			Indole Fox Green (indocyanine green)	indo-lemmon	Indomethacin (indomethacin)
Indomethacin sodium (indomethacin sodium)	Ketoprofen (indomethegan)	Indoprofen (indoprofen)
			inductos	infanrix?hepb	Novel six department of pediatrics vaccines (infanrix hexa)
infanrix?penta	infants′feverall	Pulmoalveolar surfactant (infasurf)
			infed	Infergen (interferon alfacon-1)	Prednisone phosphorus (inflamase)
Morphine sulfate (infumorph)	Infuvite (Multivitamin transfusion)	Estradiol (innofem)
			Low molecular weight heparin injection (innohep)	Acid Propranolol timing and controlled release capsule (innopran xl)	Nitric oxide release type product (inomax)
inpersol-lc/lm	Eplerenone (inspra)	Because of speed reaches regular iletin (insulatard)
			Insulin	Insulin (recombinant human insulin)	Reorganization insulin aspart (insulin

		aspart?recombinant)
			The insulin detemir recombinagen (insulin detemir recombinant (	Insulin Glargine recombinagen (insulin glargine recombinant)	Lispro's recombinagen (insulin lispro protamine recombinant)
Iletin II (Lilly) purification thing (insulin purified pork)	The recombinant human insulin	Insuman (insuman)
			Atomized soln (intal)	Eptifibatide (integrilin)	The a-2b interferon (interferon alfa-2b (intron, peg-intron, pegasys))
Lipomul (intralipid)	Cloudy emerald green husky (intrinsa)	Introna (interferon alfa 2b)
			invagesic	Ertapenem sodium (invanz)	Mecamylamine (inversine)
Saquinavir (invirase)	Iobenguane sulfate (iobenguane sulfate i 131)	Iobenguane meglumine (iodipamide meglumine)
			Iodixanol (iodixanol)	Iodine isotope (iodotope)	Iohexol inj (iohexol)
Duromine (ionamin)	Ioversol (ionosol)	Fentanyl (ionsys)
			Iopamidol (iopamidol)	Apraclonidine (iopidine)	Iopromide (iopromide)
iosat	Opacin acid meglumine (iothalamate meglumine)	Angio-conray (iothalamate sodium)
			He draws sour sodium injection (iothalamate sodium i-125) iodine [123I]	Ioversol (ioversol)	The husky Portugal's amine (ioxaglate meglumine) of iodine
Ioxaglate sodium (ioxaglate sodium)	Ioxilan (ioxilan)	iplex
			Ipratropium bromide	iprivask	Iproniazid
Ipsapirone (ipsapiraone)	1.5% levofloxacin eye drop (iquix)	Iressa (iressa)
			Irinotecan hydrochloride (irinotecan hydrochloride)	Iron dextran (iron dextran)	Sucrose ferrum (iron sucrose)
Clopidogrel (iscover)	Ismo (ismo)	Hydrochloric acid isobutamben (isocaine hydrochloride)
			Isocarboxazid	The hydrochloric acid dilabron	Isoflurane
isolyte	6-methylamino-2-methylheptene (isometheptene)	Isoniazid
			Isoproterenol (isoproterenol)	Tartaric acid different third [nor-] epinephrine (isoproterenol bitartrate)	The hydrochloric acid isoprenaline
Verapamil (isoptin)	Isotope order peaceful (isopto cetamide)	Sorbide nitrate (isordil)
			Sorbide nitrate (isosorbide dinitrate)	Isosorbide 5-mono-nitrate (isosorbide mononitrate)	Isosulfan blue (isosulfan blue)
Radio sulfur is for gentamycin (isotonic gentamicin sulfate)	Iopamidol (isovue)	Isradipine (isradipine)
			istalol	Isuprel (isuprel)	Itraconazole (itraconazole)
ivadal	ivy?block	Apomorphine hydrochloride (ixense)

jantoven	jeanatope	joi-risperidone
			junel	k+10	k+8
Morphine sulfate slow release capsule (kadian)	Lopinavir (kaletra)	Kanamycin (kanamycin)
			Kanamycin sulfate (kanamycin sulfate)	Kanamycin (kantrex)	kaon?cl-10
kariva	Irb (karvea)	Irbesartan, hydrochlorothiazide (karvezide)
			Kayexalate (kayexalate)	Candesartan (k-dur)	Cephalexin (keflex)
kefurox	Cefuroxime (kefzol)	kelnor
			Kemadrin (kemadrin)	Baclofen oral cavity disintegration tablet (kemstro)	Triamcinolone acetonide (kenacort)
Triamcinolone (kenalog)	Oxibutynin (kentera)	kepivance
			Levetiracetam (keppra)	Betaxolol hydrochloride (kerlone)	Ketamine (ketalar)
Ketamine (ketamine)	Ketalar (ketamine hydrochloride)	Ketek (ketek)
			Ketone ibuprofen (ketoprofen)	Ketone ibuprofen (ketoprofen)	Ketorolac (ketorolac)
Ketorolac tromethamine (ketorolac tromethamine)	Ketotifen (ketotifen)	Ketoconazole (ketozole)
			Antril (Synergen) (kineret)	Sincalide (kinevac)	kinzalkomb
Telmisartan (kinzalmono)	Kayexalate (kionex)	kiovig
			Ketanserin (kitanserin)	The combination formulations of Abacavir and 3TC (kivexa)	Sulphacetamide lotion (klaron)
Clonazepam (klonopin)	Candesartan (klor-con)	Potassium chloride (klotrix)
			Section's base hemagglutinin Factor VIII injection (kogenate bayer)	k-tab	kudeq
Kang Quan (kytril)	Labetalol hydrochloride (labetalol hydrochloride)	lac-hydrin
			Hydroxypropyl cellulose (lacrisert)	(lactated ringer ' s) for sodium lactate ringer's	Lactulose
1-α acetylmethadol	Lamotrigine (lamictal)	Terbinafine (lamisil)
			Isoniazid (laniazid)	lanorinal	Lanoxicaps (lanoxicaps)
Digoxin (lanoxin)	Lansoprazole (lansoprazole)	Insulin Glargine (lantus)
			Chlorpromazine (largactil)	Mefloquine (lariam)	Amoxicillin (larotid)
laryng-o-jet?kit	Furosemide (lasix)	laxilose
			Lazabemide (lazabemide)	I is watt (leflunomide)	lente?iletin?ii(pork)
Lepirudin 023 ludon (lepirudin recombinant)	Leptin (leptin)	Lescol see fluvastatin (lescol)
			Lesopitron (lesopitron)	lessina-28	Calcium leucovorin (leucovorin calcium)
Chlorambucil (leukeran)	Leukine (leukine	The anti-granulocyte monoclonal antibody of labelling

	?[sargramostim])	(leukoscan)
			Leuprorelin (leuprolide acetate)	Cladibrine (leustatin)	Albuterol hydrochloride
Levofloxacin is dissolved in 5% glucose (levaquin)	Pindolol (levatol)	Insulin (levemir)
			Vardenafil (levitra)	?levlite	Levobunolol Hydrochorid (levobunolol hydrochloride)
Levocarnitine oral solution (levocarnitine)	Levodopa (levodopa)	Dromoran (levo-dromoran)
			Levofloxacin hydrochloride (levofloxacin)	?levolet	Levonorgestrel (levonorgestrel)
Norepinephrine tartaric acid (levophed)	Levonorgestrel and ethinylestradiol sheet (levora)	Levorphanol (levorphanol)
			Levorphanol tartrate (levorphanol tartrate)	?levo-t	Thyroxine (levothroid)
Levothyroxine sodium (levothyroxine sodium)	Dextrothyroxine sodium (levoxyl)	Hydrochloric acid 5-amino-laevulic acid (levulan)
			Polrvinyl chloride/aluminum (levviax)	Escitalopram (lexapro)	lexiva
Enalapril maleate, felodipine (lexxel)	Chlordiazepoxide (librium)	Fluocinolone acetonide (lidex)
			Lignocaine	Lignocaine hydrochloric acid	The viscosity lignocaine
Epinephrine (lidocaton)	Lidocaine patch 5% (lidoderm)	Lignocaine (lidopen)
			?lidosite?topical?system?kit	?lignospan	Limbitrol (amitriptyline and chlordiazepoxide)
Lincomycin hydrochloric acid (lincocin)	Lincomycin hydrochloride (lincomycin hydrochloride)	Gamma hch lotion (lindane)
			Linezolid (linezolid)	Baclofen (lioresal)	Cyronine (liothyronine sodium)
Atorvastatin calcium (lipitor)	Intravenous injection fatty emulsion liposyn ()	Lisinopril (lisinopril)
			Lisinopril (lisinopril)	Lisuride	litak
Lithium carbonate (lithium carbonate)	Lithium citrate (lithium citrate)	Lithium carbonate (lithobid)
			Acetohrdroxamic acid (Lithostat)	?livensa	Levocabastine (livostin)
?lo/ovral-28	?locacorten?vioform	locholest
			Hydrocortisone butyrate (locoid)	Etodolac (lodine)	Carbidopa (lodosyn)
Ethinylestradiol and norethindrone (loestrin)	Lofentanil (lofentanil)	Lofepramine (lofepramine)
			Fragrant promise ester and atropine (lomotil)	Lomustine (lomustine)	Minot sheet (loniten)
The fragrant promise ester (lonox) of atropine	Loperamide hydrochloride (loperamide hydrochloride)	Gemfibrozil (lopid)

Loprazolam (loprazolam)	Spectinomycin hydrochloride (lopressor)	Ring pyrrole gel (loprox)
			Allopurinol (lopurin)	Loracarbefabid (lorabid)	Loratadine (loratidine)
Lorazepam (lorazepam)	L0 (lorazepam intensol, lorazepam)	?lorcet-hd
			Probucol (lorelco)	lorexan	Lorazepam (lorezepam)
lortab	Lu Dashu (lotemax)	Benazepril (lotensin)
			Amlodipine Besylate Tablet and benazepril hydrochloride (lotrel)	Clotrimazole (lotrimin)	Clotrimazole and betamethasone (lotrisone)
Alosetron hydrochlorate (lotronex)	Lovastatin (lovastatin)	Enoxaparin sodium injection (lovenox)
			low-ogestrel	Loxapine (loxapine)	Loxapine succinate (loxapine succinate)
Loxapine (loxitane)	Indapamide (lozol)	?lta?ii?kit
			Neutraphylline (lufyllin)	Bimatoprost (lumigan)	?luminity
Estazolam (lunesta)	Leuprorelin acetate (lupron)	A-lutropin (lutropin alfa)
			luveris	Betamethasone (luxiq)	Isosulfan blue (lymphazurin)
Lyophilized cyclophosphamide (lyophilized cytoxan)	Lyrica (lyrica)	Mitotane (lysodren)
			m.t.e.-4/m.t.e-6	m.v.i.	Bank Paasche (mabcampath)
Rituximab (Mabthera)	Nitrofurantoin (macrobid)	Nitrofurantoin (macrodantin)
			Albumin is (macrotec) generally	Piperazine Jia Tani sodium (macugen)	Magnesium sulfate (magnesium sulfate)
Magnevist (magnevist)	Horse traction swells (malarone)	Manganous chloride (manganese chloride)
			Formula mannitol injection liquid (mannitol)	Aueural (maprotiline hydrochloride)	Maprotiline (maprotoline)
Bupivacaine hydrochloride (marcaine)	marcaine?hydrochloride	Dronabinol (marinol)
			Isocarboxazid (marplan)	Benzyl hydrazine (matulane)	Puli (mavik)
Pirbuterol (maxair)	Lizakuputan benzoate (maxalt)	Lomefloxacin hydrochloride (maxaquin)
			Dexamethasone (maxidex)	Hydrochloride for injection cefepime (maxipime)	Neomycin, polymyxin B and dexamethasone eye (maxitrol)
Phenalgin and hydrochlorothiazide (maxzide)	Mazindol (mazindol)	Miconazole (Mazipredone)
			md-76r	md-gastroview	?mdp-bracco
Mebendazole (mebendazole)	Mecasermin recombinagen (mecasermin recombinant)	Reorganization mecasermin (mecasermin rinfabate recombinant)
			Hydrochloric acid chlormethine (mechlorethamine hydrochloride)	Meclozine hydrochloride (meclizine hydrochloride)	Meclofenamate (meclofenamate)
Meclofenamate sodium (meclofenamate sodium)	Mecloqualone (mecloqualone)	Dexmedetomidine hydrochlorate (medetomidine)

Medifoxamine (medifoxamine)	Ibuprofen (medipren)	Methyl meticortelone (medrol)
			Medroxyprogesterone acetate (medroxyprogesterone acetate)	Mefloquine (mefloquine)	Mefloquine Hydrochloride (mefloquine hydrochloride)
Cefoxitin (mefoxin)	Megestrol acetate (megace)	megatope
			Megestrol acetate (megestrol acetate)	Buronil (melperone)	Hydrochloric acid alkeran (melphalan hydrochloride)
Memantine (memantine)	Estrogen (menest)	U.S. promise pregnant (menopur)
			Menostar estradiol weekly-transdermal	Menotropin (menotropins)	Butenafine (mentax)
Menthol	Pethidine (meperidine)	Pethidine hydrochloride (meperidine hcl)
			Pethidine hydrochloride (meperidine hydrochloride)	Vitamin K (mephyton)	Mepivacaine Hydrochloride (mepivacaine hydrochloride)
Meprobamate (meprobamate)	Meprobamate (mepron)	Meptazinol (meptazinol)
			Purinethol (mercaptopurine)	Sibutramine (meridia)	Meropenem (meropenem)
merrem?i.v.	Mesalazine (mesalamine)	m-eslon
			Mesna (mesna)	Mesnaum (mesnex)	Mesoridazine (mesoridazine)
Pyridostigmine (mestinon)	Methyl ester hydrochloride (metadate)	Glipizide/metformin hydrochloride (metaglip)
			Methionine Ah lyze (metalyse)	Metampicilline (metampicillin)	Hydroxyphenyl isopropylamino ethanol
Metaproterenol sulfate	Metaraminol Bitartrate (metaraminol bitartrate)	Strontium-89 sodium chloride injection (metastron)
			Metformin (metformin)	Metformin hydrochloride (metformin hydrochloride)	Choline (metha chloride)
Methadone (methadone)	Methadone hydrochloride (methadone hydrochloride)	Methadone hydrochloride oral liquid concentrate (methadose)
			Methaqualone	Methazolamide (methazolamide)	Methenamine hippu (methenamine hippurate)
Maleic acid (Methergine)	The methicillin	Thiamazole or thiamazole (methimazole)
			Methocarbamol (methocarbamol)	Methohexital sodium (methohexital sodium)	Methotrexate (Lin En) (methotrexate)
Methotrexate sodium (methotrexate sodium)	Methoxsalen (methoxsalen)	methprylon
			Mesuximide (methsuximide)	Methyclothiazide (methyclothiazide)	Methyl (methyldopa)
Methyldopate hydrochloride (methyldopate hydrochloride)	Methyl (methylin)	Methyl ester (methylphenidate)
			Hydrochloric acid BA4311 (methylphenidate	Methyl meticortelone (methylprednisolone)	Acetic acid methyl meticortelone (methylprednisolone acetate)

hydrochloride)
			Methylprednisolone sodium succinate (methylprednisolone sodium succinate)	The methyl testosterone	methyphenidate
Methyprylon (methyprylon)	Desernil	Hydrochlorate (metipranolol)
			Metoclopramide	Metoclopramide hydrochloric acid	Methophenazine (metofenazate)
Metolazone-oral (metolazone)	Hypnodil V (metomidate)	Metopimazine (metopimazine)
			Metyrapone (metopirone)	Metopon	Metoprolol (metoprolol)
Spectinomycin hydrochloride (metoprolol tartrate)	Bungarotoxin (metralindole)	metro?i.v.
			Metrocream (metronidazole external emulsifiable paste)	Metrogel (metrogel)	Metronidazole lotion (metrolotion)
Metronidazole (metronidazole)	Methylamino frost (metvixia)	Lovastatin (mevacor)
			Hydrochloric acid mexiletine (mexiletine hydrochloride)	Rule hydrochloric acid (mexitil)	Calcitonin salmon (miacalcin)
Mianserin (mianserin)	micafungin?sodium	Telmisartan sheet (m icardis)
			Miconazole (miconazole)	micort-hc	micro
micro+4/micro+5/micro+6/m icro?cr/micro?cu/micro i/micro?mn/micro?se	microderm	microgestin
			Glibenclamide (micronase)	Norethindrone (micronor)	The medicine of hydrochlorothiazide-oral (microzide)
Amiloride (midamor)	Midazolam injection (stabilizing) (midazolam)	midazolam?hydrochloride
			Hydrochloric acid midodrine (midodrine hydrochloride)	Mifepristone (mifeprex)	Cafergot (migergot)
GANKANG (migranal)	Milnacipran hydrochloride (milnacipran)	Milophene (milophene)
			Primacor (Sterling-Winthrop). (milrinone lactate)	Sleeping pill (miltown)	mimpara
Minaprine (minaprine)	Norethindrone acetic acid-ethinylestradiol (minestrin)	Minipress (minipress)
			Desmopressin/nasal spray (minirin)	minitran	Prazosin (minizide)
Minocin capsule (minot) (minocin)	Minocycline (minocycline) (minocycline)	Hydrochloric acid minocycline (minocycline hydrochloride)
			Minot (minoxidil)	Probenazole (mintezol)	Artificial acecoline solution (miochol)
Miostat (the artificial solution of carbachol)	Anisindone (miradon)	Polyethylene Glycol 3350 (miralax)
			Miraluma (technetium)	Mirapex (pramipexole piperazine sheet)	Pramipexole (mirapexin)

Mircette (desogestrel, ethinylestradiol and ethinylestradiol)	Mirena (levonorgestrel discharges in utero system)	Mirtazapine (mirtazapine)
			Misoprostol (misoprostol)	Mithramycin (mithracin)	Mitomycin (mitomycin)
Mitoxantrone (mitoxantrone)	Mitoxantrone hydrochloride (mitoxantrone hydrochloride)	Chloride (mivacron)
			Mivacurium chloride (mivacurium chloride)	: contain 30% regular iletin (regular insulin) and 70% insulin suspension,NPH (mixtard)	m-m-rvaxpro
Molindone piperazine sheet (moban)	Meloxicam (mobic)	Meloxicam (mobicox)
			Moclobemide (moclobemide)	Cartric (moderil)	Mo Dikang (modicon 28)
Amiloride and hydrochlorothiazide (moduretic)	Moexipril hydrochloride (moexipril hydrochloride)	Hydrochlorate (mofegiline)
			molindrone	Momestasone furoate (mometasone furoate)	Miconazole nitrate (monistat)
Doxycycline (monodox)	Sorbide nitrate-oral (monoket)	Fosinopril sodium (monopril)
			Lente insulin (monotard)	Fosfomycin (monurol)	Morphine
Morphine sulfate	Difenoxin and atropine (motofen)	Ibuprofen (motrin)
			Moxifloxacin hydrochloride (moxifloxacin hydrochloride)	mpi?dmsa?kidney?reagent	mpi?dtpa?kit-chelate
mpi?indium?dtpa?in?111	ms?contin	Heal and Pseudoephedrine (mucinex)
			Heal and Pseudoephedrine (mucinex d)	Acetyl (mucomyst)	multi-11/multi-12
multihance	Mupirocin (mupirocin)	muse
			Chlormethine hydrochloric acid (mustargen)	Mitomycin (mutamycin)	Ethambutol (myambutol)
Codeine phosphate, hydrochloric acid bromazine (mybanil)	Micafungin sodium (mycamine)	Clotrimazole (mycelex)
			Mycobutin (mycobutin)	mycodone	Hydrochloric acid mycophenolate mofetil (mycophenolate mofetil hydrochloride)
Nystatin (mycostatin)	Tropicamide (mydriacyl)	Mycophenolic acid (myfortic)
			Nystatin (mykacet)	mylaramine	Busulfan (myleran)
mylotarg	Dexamethasone (mymethasone)	myobloc?botulinum?toxin?type b
			Liposomal doxorubicin (myocet)	myoview	myozyme
myphetane	myproic?acid	Desoxyphenobarbital (mysoline)
			Ambenonium chloride ambenonium chloride (mytelase)	mytozytrex	Rice azoles (m-zole)

?neupopeg	Neupro (rotigotine transdermal system)	The neurobloc Botulinum toxin)
			Neurolite (neurolite)	Gabapentin (neurontin)	Glucuronic acid trimetrexate powder (neutrexin)
?neutrospec[technetium ?fanolesomab]	Ophthalmology suspension (Nepafenac nevanac)	Oral many inhibitors of kinases (nexavar)
			Esomeprazole magnesium (nexium)	?nexium?iv	Nicotinic acid (niacin)
Nicotinic acid tablet (niacor)	Nicotinic acid (niaspan)	Hydrochloric acid nicardipine (nicardipine hydrochloride)
			Nicergoline (nicergoline)	Nicotine transdermal (nicoderm cq)	Nicotine (nicorette)
Nicotine	Polacrilex,nicotine (nicotine polacrilex)	Nicotine intake system (nicotrol)
			Nifedipine (nifedipine)	Nilutamide (nilandron)	Nystatin (nilstat)
Cisatracurium Horizon (Cisatracurium nimbex)	Nimodipine (nimotop)	Pentostatin powder (nipent)
			Alprazolam (niravam)	Hydrochloric acid (nisoxetine)	Nitroglycerin (nitro-dur)
Nitrofurantoin (nitrofurantoin)	Nitrofural (nitrofurazone)	Nitroglycerine
			Nitrol (nitrol)	Nitrolingual (nitrolingual)	Sodium nitroprusside (nitropress)
Nitroglycerine (nitrostat)	Nitrous oxide	nix
			Nizatidine (nizatidine)	Ketoconazole (nizoral)	Tamoxifen Citrate (nolvadex)
Nomifensine (nomifensine)	?nonafact	norco
			?nordette-28	Growth hormone injection (norditropin)	norditropin?nordiflex
Noradrenaline bitartrate (norepinephrine bitartrate)	?norethin	Norethindrone (norethindrone)
			Norethindrone acetate (norethindrone acetate)	Orphenadrine citrate (norflex)	norgesic
Norinyl (norinyl)	Metronidazole (noritate)	normosol
			Norfloxacin (noroxin)	Disopyramide phosphate (norpace)	Levonorgestrel implantation body (norplant)
West desipramine hydrochloride salt (norpramin)	?nor-qd	nortrel
			Nortriptyline	Psychostyl	Norvasc (norvasc)
The ritonavir capsule, oral liquid (norvir)	?novamine	Novantrone (novantrone)
			Venlafaxine (novo venlafaxine xr)	The novo-acebutolol	The novo-acyclovir
Betahistine Hydrochloride (novo-betahistine)	Bicalutamide (novo-bicalutamide)	Procaine hydrochloride (novocain)
			?novo-fenofibrate-s	?novolin	Novolog (insulin novorapid)
Meloxicam (novo-meloxicam)	Mirtazapine	Novomix (novomix)

	(novo-mirtazapine)
			?novonorm	Ondansetron (novo-ondansetron)	Pramipexole (novo-pramipexole)
Lu Wo is (novorapid) fast	Risperidone (novo-risperidone)	Coagulationfactor VIIA portion (reorganization) (novoseven)
			Sumatriptan (novo-sumatriptan)	Smooth (rope) Lip river new (novo-tamsulosin)	Levothyroxine sodium (novothyrox)
Oral administration mixed suspension (noxafil Posaconazole)	Methotrimeprazine (nozinan)	Nph iletin i (excellent secrete woods)
			Hydrochlorate (Nubain)	nulytely	numorphan
Hydrocortisone emulsifiable paste nutracort	Nutrilipid lipomul-injection	The nutropin growth hormone
			Pessary (nuvaring)	Isoniazid (nydrazid)	nyracta
Nystatin (nystatin)	nystop	Fat inhibin (obestatin)
			?octocaine	octreoscan	Octreotide acetate (octreotide acetate)
?ocuclear	Ocufen (ocufen)	ocuflox
			1% carteolol hydrochloride eye liquid＜(ocupress)	10% sulfacetamide eye liquid＜disulfonamide＞(ocusulf-10)	Ofloxacin (ofloxacin)
?ogen	ogestrel	olansek
			Compound recipe olanzapine (olanzapine)	Olanzapine (olazapine)	Olopatadine hydrochloride (olopatadine hydrochloride)
?olux	Cholesterol antagonist (omacor)	Omeprazole Pellets (omeprazole)
			?omnicef	Spinal canal myelography (omnipaque)	Gadodiamide and caldiamide sodium (omniscan)
Growth hormone (omnitrope)	Nitrate (omoconazole)	Pegaspargase (oncaspar [pegaspargase])
			Ondansetron (ondansetron)	Hydrochloric acid ondansetron (ondansetron hydrochloride)	Two water Zofrans (ondansetron hydrochloride dihydrate)
Muriatic ondansetron two water (ondansetron omega)	Celecoxib (o nsenal)	ontak[denileukin?diftitox]
			?opatanol	opcon-a	Proparacaine hydrochloride (ophthaine)
Proparacaine hydrochloride (ophthetic)	Cromolyn opticrom (sodium cromoglicate eye liquid)	optimark
			?optipranolol	Ioversol injection (optiray)	optison
Insulin Glargine (optisulin)	Azelastine Hcl (optivar)	RALOXIFENE HCL trade (optruma)
			?opulis	Gelatin (orabase)	oracort
?oralone	Morphine (oramorph)	Pimozide (orap)
			Steroid (orapred)	Lignocaine and prilocaine (oraqix)	Cefpodoxime Proxetil (orelox)
Hydrochlorothiazide (oretic)	orfadin	orgalutran

Brocasipal (orphenadrine)	Orphenadrine citrate (orphenadrine citrate)	Orphenadrine citrate, aspirin and coffee (orphengesic)
			?ortho?cyclen	ortho?evra	ortho?tri-cyclen
?ortho-cept	orthoclone [muromonab-cd3]	ortho-est
			?ortho-novum	Ketone ibuprofen (orudis kt)	Ketoprofen (oruvail)
Midodrine (orvaten)	osigraft	Formula mannitol injection liquid (osmitrol)
			?osseor	Bone protein (osteogenic protein-1i)	Hydrocortisone; Polygynax, Polymyxin B sulfate (oticair)
Norethindrone/ethinylestradiol-oral (ovcon)	0.5% Malathion (ovide)	Chorionic-gonadotropin hormone Alpha injects (ovidrel)
			Chorionic-gonadotropin hormone Alpha (ovitrelle)	Oxazacillin (oxacillin)	Benzene azoles injection (oxacillin sodium)
Le Shading (oxaliplatin)	Oxandrin (oxandrin)	The oxaprozin oxaprozin
			Chlorine hydroxyl oxygen phenodiazine (oxazepam)	oxilan	Oxistat (oxistat)
Hydrochlorate (oxprenolol)	Methoxsalen capsule (oxsoralen)	Oxibutynin chloro-oral (oxybutynin chloride)
			Oxibutynin (oxybutynin nicobrand)	Acetaminophen (oxycet)	Oxycodone (oxycodone)
Oxycodone (oxycontin)	Oxymorphone (oxymorphone)	Hydrochloric acid oxymorphone (oxymorphone hydrochloride)
			Oxytocin (oxytocin)	Oxibutynin (oxytrol)	Amiodarone Hydrochloride (pacerone)
Paclitaxel (paclitaxel)	Palonosetron (palonosetron)	Palonosetron Hcl (palonosetron hydrochloride)
			First is for woods hydrochlorate (pamelor)	Pamidronate Disodium (pamidronate disodium)	pamme
?pamine?forte	Pancuronium (pancuronium)	NA97 (pancuronium bromide)
			Hydrocortisone Probutate frost (pandel)	panitumumab(vectibix)	Cefalexin (panixine disperdose)
Alitretinoin gel (panretin)	Pantoprazole (pantoloc)	Pantoprazole Sodium (pantoprazole sodium)
			Papaveretum (papaveretum)	Papaverine	paracaine
Chlorzoxazone (parafon)	Carboplatin aqueous solution (paraplatin)	parareg
			Levodopa disintegrating tablet (parcopa)	Tropicamide (paremyd)	paricalcitol
Bromocriptine methanesulfonate (parlodel)	Tranylcypromine sulfate (parnate)	Paromomycin sulfate (paromomycin sulfate)
			Paroxetine () paroxetine	Paroxetine hydrochloride (paroxetinehy drochloride)	Aminosallcylic acid (paser)
The potassium para-aminosalicylic acid	Olopatadine hydrochloride (patanol)	patrex

(paskalium)
			Paclitaxel (paxene)	Paroxetine (paxil)	pbz
Tetrachloroethylene (pce)	Ibuprofen four (pedea)	Pediamycin (pediamycin)
			Prednisone (pediapred)	Digoxin department of pediatrics (pediatric digoxin)	Erythromycin (Sulfisoxazole pediazole)
Erythromycin ethylsuccinate (pediazole, erythromycin ethylsuccinate)	Neomycin, polymyxin B and hydrocortisone (pediotic)	Cattle adagen (pegademase bovine)
			Ethotoin (peganone)	Pegylation α-2A (pegasys)	pegfilgrastim(neulasta)
Pegylation α-2b interferon (pegintron)	Growth hormone receptor antagonist (pegvisomant)	Pemetrexed (pemetrexed disodium)
			Pemoline (pemoline)	penecort	Penfluridol (penfluridol)
Penicillin	Penicillin g	Penicillin n
			Penicillin o	Penicillin s	Penicillin v
Ring pyrrole (penlac)	Diclofenac (pennsaid)	The pentylenetetrazol isethionate
			pentamte	Mesalazine (pentasa)	Pentazocine
Pentazocine hydrochloric acid	The pentazocine lactate	Pentetate calcium trisodium (pentetate calcium trisodium)
			Pentaacetic acid one zinc trisodium (pentetate zinc trisodium)	pentobarbital	Pentobarbital sodium (pentobarbital sodium)
Pentolair (pentolair)	Pentostatin (pentostatin)	Pentoxifylline (pentoxifylline)
			Pentoxifylline (pentoxil)	MK-208 (pepcid)	Peptide
Oxycodone and acetaminophen/acetaminophen (percocet)	Aspirin, oxycodone hydrochloride, oxycodone ethylene glycol terephthalate (percodan)	Perflutren lipoid microsphere (perflutren)
			Perglide (pergolide mesylate)	pergolike	Pericyazine (pericyazine)
peridex	Periochip (hibitane)	periogard
			Doxycycline hydrochloride (periostat)	Benzathine penicillin G (permapen)	Pergolide mesylate (permax)
Permethrin (permethrin)	Perphenazine	Persantin (persantine)
			Pethidine	Paroxetine methanesulfonic acid (pexeva)	Scotcil (pfizerpen)
pharmaseal?scrub?care	Benzene azoles star	phencaramkde
			Anoxine-T (phendimetrazine tartrate)	Phenelzine	Promethazine (phenergan)
Phenobarbital (phenobarbital)	Phentermine (phentermine)	Phentermine hydrochloric acid (phentermine hydrochloride)
			Fragrant appropriate amine	Phentolamine mesylate	phentytoin

Risperdal (pms-risperidone)	Ursodesoxycholic acid (pms-ursodiol)	The podofilox-external-use gel
			Procaine (polocaine)	Polypeptide	B sulfo-polymyxin (polymyxin b sulfate)
Polypeptide yy	Poly--pred	Poly--rx
			Polymycin (polysporin)	Aerosporin and trimethoprim (polytrim)	Mefenamic acid (ponstel)
Porfimer sodium (porfimer sodium)	?portia-28	Posaconazole (posaconazole)
			Potassium acetate (potassium acetate)	Potassium chloride (potassium chloride)	Povidone iodine (povidone iodine)
Pyraloxime methylchloride (pralidoxime chloride)	Pramipexole (pramipexole)	Pramlintide acetate (pramlintide acetate)
			?pramosone	Repaglinide (prandin)	Provastain (pravachol)
Pravastatin (pravastatin)	?pravigard?pac	Prazosin (prazosin)
			Dexmedetomidine (precedex)	Acarbose (precose)	pred?forte
?pred?mild	?pred-g	Prednisolone acetate (prednisolone)
			Acetic acid prednisolone (prednisolone acetate)	Sodium phosphate (prednisolone)	Prednisone (prednisone)
Prednisone (prednisone intensol)	?prefest	Po Renile (pregnyl)
			?prelone	Premarin Tablet (premarin)	premasol
?premphase?14/14	?premplus	Medroxyprogesterone (prempro)
			?prentoxapylline	?pre-op	preotact
Prepidil (prepidil)	?prevacare	Prevacid (prevacid)
			Amide, phenylalanine (prevalite)	?prevenar	previfem
?prevpac	?prexige	prezista
			?prialt	?priftin	Omeprazole (prilosec)
?primacor	Primaquine (primaquine)	Primatene (primatene)
			Imipenum primaxin	The primidone primidone mysoline	primsol
Ampicillin (principen)	Prinivil (prinivil)	Lisinopril and hydrochlorothiazide (prinzide)
			?pritor	?pritorplus	proair
Proamatine midodrine	Probenecid (probalan)	Ben Xin (pro-banthine)
			Probenecid (probenecid)	Procamide (procainamide hydrochloride)	Procaine
Procaine hydrochloric acid	?procalamine	Procanbid (procanbid)
			Calcium channel blocker (procardia)	Procaterol Hydrochloride (procaterol hcl)	Prochlorperazine (prochlorperazine)

Prochlorperazine edisylate (prochlorperazine edisylate)	Prochlorperazine maleate (prochlorperazine maleate)	?procomvax
			Shi Weiya (procoralan)	?procrit[epoetin?alfa]	Hydrocortisone and (proctofoam Pramoxine)
Hydrochlorate (procyclidine)	Ibuprofen (profen)	Iron dextran (proferdex)
			Progesterone (Progesterone)	Phenodiazine-capsule (proglycem)	Tacrolimus (prograf)
prohance	?prohance?multipack	?proleukin[aldesleukin]
			Fluphenazine (prolixin)	?prolixin?decanoate	Trimethoprim (proloprim)
Promazine (promazine)	Rivastigmine (prometax)	?prometh
			promethacon	Phenergan	Phenergan hydrochloric acid
Promethazine (promethegan)	Progesterone (prometrium)	?prompt?phenytoin?sodium
			Procaine (pronestyl)	Propacetamol (propacetamol)	Propafenone hydrochloride (propafenone hydrochloride)
Propranolol (propanolol)	Propantheline bromide (propantheline bromide)	Proparacaine hydrochloride (proparacaine hydrochloride)
			Amine (propecia)	Propentofylline (propentofylline)	Propine (propine)
Diprivan see propofol (propofol)	The third oxygen sweet smell	Propranolol
			Propranolol hydrochloric acid	Propylthiouracil (propylthiouracil)	Measles, parotitis and rubella chickenpox vaccine (proquad) alive
Ciprofloxacin (proquin xr)	Amine (proscar)	?prosol
			Stable (prosom)	Prostacyclin (prostacyclin (treprostinil))	?prostascint?[capromab ?pendetide]
prostep	Alprostadil (prostin)	Protamine sulfate (protamine sulfate)
			protaphane	Protein	Strontium ranelate (protelos)
Pantoprazole (protonix)	(protonix iv) for Pantoprazole Sodium	Pralidoxime chloride (protopam chloride)
			Tacrolimus (protopic)	Tacrolimus (protopy)	MK-240 (protriptyline)
Albuterol (proventil)	Medroxyprogestetone acetate (provera)	Modafinil (provigil)
			Choline (provo)	Fluoxetine (prozac)	Pseudo ephedrine (hydrochloride)
Diflorasone sodium diacetate frost (psorcon)	Budesonide sucks suspension (pulmicort respules)	Methacrylic acid (pulmolite)
			Calcium chloride and sodium chloride solution (pulmozyme[dornase alfa])	Puregon (puregon)	Purinethol (purinethol)
pylobactell	Pyrazinamide (pyrazinamide)	Bromo mestinon (pyridostigmine bromide)
			Hydrochloric acid vitamin (B6 pyridoxine hydrochloride)	?pytest	?quadramet
Succinum sodium chloride injection (quelicin)	Cholestyramine (questran)	Seroquel (quetiapine)

Quibron (quibron)	Quinapril hydrochloride (quinapril hydrochloride)	Quinapril/hydrochlorothiazide (quinaretic)
			Gluconate conquinine (quinidine gluconate)	Quinidine sulfate (quinidine sulfate)	Quinine
quintanrix	quinupristin/dalfopristin	Polysaccharide sodium (quixidar)
			Levofloxacin eye liquid 0.5% (quixin)	Beclometasone Hyogo action framework (qvar)	rabies?immune?globulin (bayrab)
Insoluble Prussian blue (radiogardase)	Ramipril (ramace)	Ramipril (ramipril)
			Citalopram hydrobromate (ran-citalo)	The ran-citalopram	The ran-sweet smell is the slave too
ranibizumab(lucentis)	Cefaclor (raniclor)	Ranitidine (ranitidine)
			Ranitidine hydrochloride (ranitidine hydrochloride)	Right pravastatin (ran-pravastatin)	Right risperidone (ran-risperidone)
Sirolimus (rapamune)	rapilysin	raptiva
			Rasagiline (rasagiline)	Diphosphate (ratio-alendronate)	Azithromycin (ratio-azithromycin)
Bicalutamide (ratio-bicalutamide)	Ratio-butyl propanoic acid sr	The ratio-sweet smell is the slave too
			Fosinopril sodium (ratio-fosinopril)	Glibenclamide (ratio-glyburide)	Meloxicam (ratio-meloxicam)
Ondansetron (ratio-ondansetron)	Pentoxifylline is used (ratio-pentoxifylline)	Pramipexole (ratio-pramipexole)
			Ramipril (ratio-ramipril)	Ratio risperidone (ratio-risperidone)	Ratio trazodone (ratio-trazodone)
rayzon	Galantamine (razadyne)	Ribavirin (rebetol)
			rebif	Reboxetine (reboxetine)	The anti-factor (refacto)
refludan	Phentolamine mesylate (regitine)	Metoclopramide (reglan)
			Pyridine this (regonol)	Becaplermin (regranex)	regular?iletin?ii(pork)
Nabumetone (relafen)	Auspicious sand (relenza)	Hydrobromic acid (Eletriptan relpax)
			Remacemide (remacemide)	Mirtazapine (remeron)	Former times monoclonal antibody (remicade)
Remifentaniliva (remifentanil)	Hydrochloric acid remifentaniliva (remifentanil hydrochloride)	Uniprost (remodulin)
			Remoxipride (remoxipride)	Citric acid (renacidin)	Sevelamer hydrochloride (renagel)
renamin	Horizon (renedil)	Polythiazide (renese)
			reno	renocal	reno-dip
Thypaque sodium-cardiografin (renografin)	Retinoic acid (renova)	Abciximab (reopro [abciximab])
			replagal	repronex	Ropinirole hydrochloric acid (requip)
Delavirdine methanesulfonic acid (rescriptor)	Unoprostone isopropyl ester (rescula)	Mannitol (resectisol)

Reserpine (reserpine)	Calcium polystyreme sulphonate (resonium calcium)	restasis
			Temazepam (restoril)	?retavase[reteplase]	Avita Gel (retin-a)
Retinal	(retisert) implanted in fluorine An Naide injection	Zidovudine (retrovir)
			revasc	Sldenafil (revatio)	Nalmefene hydrochlorate (revex)
rev-eyes	Naltrexone (revia)	revlimid
			Reyataz Atazanavir sulfate	?r-gene?10	Budesonide (rhinocor t)
rho(d)immune?globulin (bayrho-d)	?rhodis	rho-nitro
			rhotral	?rho-triamcinolone	rhotrimine
The rhovane zopiclone	Virazole (ribasphere)	Virazole
			rid?mousse	Auranofin (ridaura)	Rifampicin (rifadin)
Rifampicin and isoniazid (rifamate)	Rifampicin (rifampin)	Rifampicin, isoniazid and pyrazinamide (rifater)
			Riluzole (rilutek)	Riluzole (riluzole)	rimactane
rimantadine?hydrochloride	Rimonabant (rimonabant)	Dimethyl sulfoxide (rimso-50)
			Lactated Ringer'S Solution (ringer ' s)	Oral liquid of metformin hydrochloride (riomet)	Diphosphate (risedronate)
Risperdal (risperidone)	?risperdal?consta	Risperdal (risperidone)
			Methyl ester (ritalin)	Ritanserin (ritanserin)	Ritodrine hydrochloride (ritodrine)
Ritodrine hydrochloride (ritodrine hydrochloride)	Rituximab (rituxan [rituximab])	Atenolol (riva-atenolol)
			Azithromycin (riva-azithromycin)	Oxazepam (riva-oxazepam)	Risperdal (riva-risperidone)
Zopiclone (riva-zopiclone)	?rivozepam	Lizakuputan benzoate (rizatriptan)
			Methocarbamol (robaxin)	Robinul (robinul)	Calitriol (rocaltrol)
Ceftriaxone sodium (rocephin)	?rocuronium?bromide	roferon-a[interferon?alfa-2a]
			Minot (rogaine)	Flumazenil (romazicon)	Rotavirus Vaccine (rotarix)
rotateq	Mesalazine (rowasa)	Oxycodone (roxicet)
			Oxycodone hydrochloride (roxicodone)	Acetaminophen (roxilox)	Dopamine (roxindole)
rozerem	Amycin (rubex)	Rubidium Rubinorm (Ifi). 82 (rubidium chloride rb-82)
			rubramin	Vitamin B12 (rubratope)	Different arteries and veins stops (rythmodan, rythmodan la)
Propafenone (rythmol)	The s-S-adenosylmethionine	Think to increase (saizen)
			Pilocarpine hydrochlorate (salagen)	Root albuterol (salbutamol sterinebs p.f.)	Salicylate
Salmaterol (salmeterol xinafoate)	Salmaterol (salmetrol)	Furosemide (saluron)

samarium?sm?153?lexidronam pentasodium	?sanctura	Ciclosporin (sandimmune)
			Kind peaceful (sandostatin)	Kind La Er (sandostatin/ sandostatin lar)	Shandeshi (sandoz acebutolol)
Anagrelide (sandoz)	Atenolol (sandoz atenolol)	Sang Duosi azithromycin (sandoz azithromycin)
			Sang Duosi bicalutamide (sandoz bicalutamide)	Butyl propanoic acid (sandoz)	Ceftriaxone sodium (sandoz ceftriaxone)
Sang Duosi clonazepam (sandoz clonazepam)	Sang Duosi ciclosporin (sandoz cyclosporine)	Sang Duosi diltiazem (sandoz diltiazem)
			Estradiol patch (sandoz estradiol derm)	Many these famciclovirs (sandoz famciclovi) of r Mulberry	Novartis's felodipine (sandoz felodipine)
Sang Duosi fluoxetine (sandoz fluoxetine)	Gliclazide (sandoz gliclazide)	Glimepiride (sandoz glimepiride)
			Novartis's glibenclamide (sandoz glyburide)	Sang Duosi leflunomide (sandoz leflunomide)	Sang Duosi lovastatin (sandoz lovastatin)
Sang Duosi metformin (sandoz metformin)	Sang Duosi metoprolol (sandoz metoprolol)	Many these mirtazapines (andoz mirtazapine) of s Mulberry
			Nabumetone (sandoz nabumetone)	Nitrodiazepam (sandoz nitrazepam)	Ondansetron (sandoz ondansetron)
Sang Duosi paroxetine (sandoz paroxetine)	Sang Duosi pravastatin (sandoz pravastatin)	Sang Duosi risperidone (sandoz risperidone)
			Sang Duosi albuterol (sandoz salbutamol)	Simvastatin (sandoz simvastatin)	Sotalol (sandoz sotalol)
Sumatriptan (sandoz sumatriptan)	Ticlopidine (sandoz ticlopidine)	Sang Duosi appropriate (sandoz topiramate)
			Sodium valproate (sandoz valproic)	Sang Duosi zopiclone (sandoz zopiclone)	Fluoxetine Hydrochloride (sarafem)
sativex	?savene	?scandonest
			Intracavity aerosol (sclerosol)	Scopolamine	Levonorgestrel (seasonale)
The sebivo Sebivo	Dormancy sodium (secobarbital sodium)	Dormancy sodium (seconal sodium)
			secremax	Secretin (secretin synthetic human)	Pancreas Sus domestica is secreted his serine (secretin synthetic porcine) of hydrogen
Sectral (sectral)	?sedapap	Ji Lan (selegiline)
			Acid selegiline (selegiline hydrochloride)	Selenium sulfide (selenium sulfide)	Sele-Pak (selepen)
selsun	Selenium sulfide (semprex-d)	?sensipar
			Bupivacaine (sensorcaine)	Trimethoprim (septra)	Salmaterol (serevent)
Sermorelin acetate (sermorelin acetate)	Cycloserine (seromycin)	Clomiphene (serophene)
			Seroquel (seroquel)	?serostim	Reserpine (serpalan)

Sertindole (sertindole)	Sertraline (sertraline)	Sevoflurane (sevoflurane)
			?shade?uvaguard	Sibutramine (sibutramine)	Pramipexole (sifrol)
Viagra (sildenafil)	silgard	Silver sulfadiazine (silvadene)
			Shu Lai (simulect)	Simvastatin (simvastatin)	Sincalide (sincalide)
?sine-aid	Breath peaceful (sinemet)	Doxepin (sinequan)
			Rust sodium in the Meng (singulair)	Cardiografin (sinografin)	skelaxin
Tiludronate (skelid)	Sodium acetate (sodium acetate)	Sodium phenylacetate and sodium benzoate (sodium benzoate/sodium phenylacetate)
			?sodium?bicarbonatee	Butabarbital Sodium (sodium butabarbital)	Sodium chloride (sodium chloride)
Sodium chromate (sodium chromate)	Sodium ferric gluconate (sodium ferric gluconate complex)	Sodium iodide (sodium iodide)
			Sodium lactate (sodium lactate)	Sodium nitroprusside (sodium nitroprusside)	sodium?p.a.s.
Sodium phosphate	Kayexalate sodium (sodium polystyrene sulfonate)	14 sulfate sodium (sodium tetradecyl sulfate)
			?solage	solaraze	soltamox
?solu-cortef	Methyl meticortelone (solu-medrol)	Suo Ma (soma)
			Human growth hormone (somatropin recombinant)	Somatostatin (somatuline)	somavert
Suo Nata (sonata)	Chlorpromazine hydrochloride (sonazine)	Sound Novi (sonovue)
			Sorbitol (sorbitol)	soriatane	sorine
Sotalol (sotalol)	Sotalol hydrochloride (sotalol hydrochloride)	Sodium 14 sulfate (sotradecol)
			Isotretinoin (sotret)	soyacal	Econazole nitrate (spectazole)
Grand sight hydrochloric acid (spectinomycin hydrochloride)	Cefditoren pivoxil Cephalosporins (spectracef)	spectrobid
			?spheramine	spiperone	Tiotropium bromide (spiriva)
Spironolactone (spironolactone)	Itraconazole (sporanox)	Ethinylestradiol (sprintec)
			?sprycel	Sodium kayexalate (sps:sodium polystyrene sulfonate)	ssd
Sulfadiazine (ssd:silver sulfadiazine)	Butorphanol (stadol)	Levodopa (stalevo)
			Nateglinide (starlix)	Trifluoperazine (stelazine)	Anti-naus (stemetil)
Choline solution (sterile provo)	Sterile vancomycin hdrochloride (sterile vancomycin hydrochloride)	Hibitane (steri-stat)

Steroid (steroids)	The spy of section (stie-cort)	Ring pyrrole (stieprox)
			Desmopressin acetate nasal spray (stimate)	Mo Shadong (stocrin)	Stirrat draws (strattera)
Streptokinase (streptase [streptokinase])	Streptomycin sulfate (streptomycin sulfate)	Streptozotocin (streptozocin)
			Testosterone (striant)	Chlorzoxazone (strifon)	Ivermectin (stromectol)
Strontium chloride strontium 89 (strontium chloride sr-89)	Fentanyl (sublimaze)	Buprenorphine naloxone (suboxone)
			Third promise coffee-Sublingual (subutex)	Choline (succinyl chloride)	sucraid
Sucralfate (sucralfate)	Pseudoephedrine (sudafed)	Sufentanil (sufenta)
			Sufentanil (sufentanil)	Sufentanil citric acid (sufentanil citrate)	Nisoldipine (sular)
Sulfur-bearing 10 (sulf-10)	Sulfacetamide (sulfacel-15)	Sulphacetamide (sulfacetamide sodium)
			Sulfadiazine (sulfadiazine)	Methoxy (sulfamethoprim)	Sulfamethoxazole/trimethoprim (sulfamethoxazole/trimethopr im)
Sulfamylon (sulfamylon)	Sulfasalazine (sulfasalazine)	Trimethoprim-sulfamethoxazole (sulfatrim)
			Sufentanil citric acid (sulfentanil citrate)	Sulfinpyrazone (sulfinpyrazone)	Gantrisin (sulfisoxazole)
Sulindac (sulindac)	Sulpiride (sulpiride)	Sumatriptan (sumatriptan)
			Sumatriptan Succinate (sumatriptan succinate)	Tetracycline (sumycin)	Desflurane (suprane)
Cefixime (suprax)	Buserelin acetate (suprefact)	surfactants
			Calcifediol (surgam)	Trimipramine maleate (surmontil)	A-60386X (survanta)
Yi Feiweilun (sustiva)	Sutent (sutent)	symbicort?turbuhaler
			Olanzapine and fluoxetine (symbyax)	Symlin (symlin)	Adamantanamine hydrochloride (symmetrel)
Hydrocortisone (synacort)	?synagis	Fluorine acetic acid (synalar)
			Aspirin (synalgos-dc)	Synarel (synarel)	Lignocaine/fourth card (synera)
Pu Ting (synercid)	Levothyroxine sodium (synthroid)	Trientine dihydrochloride (syprine)
			Ibuprofen (tab-profen)	Metrizamide (tachosil)	Tacrolimus (tacrolimus)
Safe stomach U.S. (tagamet)	Talacen (talacen)	Pulvis Talci (talc)

Martindale (taluvian)	Naloxone (talwin)	Flecainide (tambocor)
			Oseltamivir phosphate capsule (tamiflu)	Tamofen rafter acid tamoxifen	Tamoxifen Citrate (tamoxifen citrate)
Tandospirone (tandospirone)	tao	Te Luokai (tarceva)
			Bexarotene (targretin)	Tal fibre card (tarka)	Fructus Colocasiae Esculentae (taro-paroxetine)
Tolcapone (tasmar)	Clemastine (tavist)	Paclitaxel (taxol)
			Taxotere (taxotere)	The tazicef ceftazidime	Tazorac tazarotene gel
Diltiazem (taztia)	technecoll	technelite
			technescan	technescan?gluceptate	Methacrylic acid (technescan maa)
technescan?mag3	technescan?pyp?kit	99 meters of technetium technetiums (technetium tc 99m)
			Technetium technetium 99 off-white albumen technetium tc-99m albumin	technetium?tc-99m?apcitide	99 meters bicisates of technetium technetium (technetium tc-99m bicisate)
99 meters depreotides of technetium technetium (technetium tc-99m depreotide)	99 meters disofenins of technetium technetium (technetium tc-99m disofenin)	99 meters exametazimes of technetium technetium (technetium tc-99m exametazime)
			technetium?tc-99m?gluceptate	99 meters mebrofenins of technetium technetium (technetium tc-99m mebrofenin)	99 meters Medronates of technetium technetium (technetium tc-99m medronate)
99 meters mertiatides of technetium technetium (technetium tc-99m mertiatide)	99 meters Oxidronates of technetium technetium (technetium tc-99m oxidronate)	99 meters pentaacetic acids of technetium technetium (technetium tc-99m pentetate)
			99 meters pyrophosphates of technetium technetium (technetium tc-99m pyrophosphate)	99 meters erythrocytes of technetium technetium (technetium tc-99m red blood cell)	99 meters of technetium technetiums (technetium tc-99m sestamibi)
99 meters mercapto succinic acid of technetium technetium (technetium tc-99m succimer)	99 meters sulfur colloid of technetium technetium (technetium tc-99m sulfur colloid)	99 meters tetrofosmins of technetium technetium (technetium tc-99m tetrofosmin)
			Diltiazem hydrochloride (teczem :)	Carbamazepine (tegretol)	Teicoplanin (teicoplanin)
Telmisartan (telmisartan boehringer ingelheim pharma kg)	telzir	Temazepam (temazepam)
			Temozolomide (temodal)	Temozolomide (temodar)	Clobetasol propionate emulsifiable paste and ointment (temovate)
tencon	tenecteplase?boehringer ingelheim?pharma?kg	Guanidine (tenex)
			Teniposide (teniposide)	Atenolol and chlortalidone (tenoretic)	Atenolol tablet (tenormin)
Tonsilon (3-hydroxyphenyl) dimethylammonium (tensilon)	tenuate	Gatifloxacin (tequin)
			Terazol (terazol)	Terazosin hydrochloric acid (terazosin	Terbinafine (terbinafine)

	hydrochloride)
			Terbutaline (terbutaline)	Terbutaline sulphate (terbutaline sulfate)	Miconazole-vagina butter (terconazole)
Terguride (terguride)	Ma Linde Qwest (teril)	Teriparatide (teriparatide recombinant human)
			?terra-cortril	Oxytetracycline (terramycin)	teslac
Tertiary sodium phosphate (teslascan)	Benzonatate (tessalon)	Testosterone gel (testim)
			Testosterone	Testosterone (testosterone cypionate)	Testosterone heptanoate (testosterone enanthate)
Testosterone propionate (testosterone propionate)	Testosterone acetic acid (testosteroneacetate)	Testosterone heptanoate (testosteroneenanthate)
			Testosterone propionate (testosteroneproprionate)	testred	tetanus?immune?globulin (baytet)
Quadracycline (tetracycline hydrochloride)	Tetrahydrocannabinol	Tetracycline (tetrex)
			Eprosartan methanesulfonic acid (teveten)	Growth hormone (tev-tropin)	Hydrocortisone (texacort)
Chlortalidone (thalitone)	Thallium thallium chloride-201 (thallous chloride tl-201)	Neurosedyn (thalomid)
			?tham	Te Lin (thelin)	Theo-24 (theo-24)
?theochron	Theophylline sheet (theolair)	Theophylline (theophylline)
			Silver sulfadiazine thermazene ()	Minot (theroxidil)	theryttrex
Thiamine hcl (thiamine hydrochloride)	Thioguanine (thioguanine)	Thioridazine
			Add six Qun Dynasty's hydrochloric acid	Plug is for sending (thiotepa)	Thiothixene (thiothixene)
?thiothixene?hydrochloride	Chlorpromazine (thorazine)	Thyrogen (thyrogen)
			Thyrolar (triiodo mixture)	thyrosafe	Potassium iodide (thyroshield)
Thyrotropin Alpha injection (thyrotropin alfa)	Hydrochlorate (tiagabine)	Tianeptine (tianeptine)
			Diltiazem (tiazac)	Ticarcillin (ticar)	Ticarcillin disodium (ticarcillin disodium)
Sulfoxide penicillin (ticarcillin)	Ticlopidine (ticlid)	Ticlopidine hydrochloride (ticlopidine hydrochloride)
			Kipling new (tigan)	For (tigecycline)	The tikosyn dofetilide
Nedocromil (tilade)	T Ticarcillin/Clavulanate Acid (imentin)	Timolol (timolide)
			Timolol maleate (timolol)	Timolol maleate (timolol maleate)	Timolol (timoptic)
Tinidazole (tindamax)	tinzaparin?sodium	Tioconazole (tioconazole)
			Tiopronin (tiopronin)	Tiotropium bromide	Tirofiban hydrochloride (tirofiban hydrochloride)
?tis-u-sol	Tizanidine (tizanidine)	Tizanidine (tizanidine

		hydrochloride)
			Tnkase[tenecteplase] replace and how to replace general enzyme	?tobi	Tobradex spongaion (tobradex)
Tobramycin	The sulphuric acid tobramycin	tobrasone
			Tobramycin (tobrex)	Tofenacin (tofenacin)	Imipramine (tofranil)
First sulphur nitrogen grass urea (tolazamide)	Tolbutamide (tolbutamide)	Tolcapone (tolcapone)
			Tolectin (tolectin)	Tolfenamic acid (tolfenamate)	Tolfenamic acid (tolfenamicacid)
Tolazamide (tolinase)	Bristol rice spit of fland sodium (tolmetin sodium)	Appropriate safe film clothing ingot (topamax)
			Desoximetasone (topicort)	?topilox	Topiramate-(topiramate)
Etoposide (toposar)	Topotecan hydrochloride (topotecan hydrochloride)	Metroprolol succinate sustained-release sheet (toprol)
			Thiethylperazine (torecan)	Torasemide (torsemide)	t-phyl
tpn?electrolytes	Bosentan sheet (tracleer)	Bosentan sheet (tracleer)
			South turtle (south celebrating), (tracrium)	Atosiban (tractocile)	Tramadol (tramadol)
Rapids safe low (trandate)	Tranexamic acid (tranexamic acid)	tranmep
			Hyoscyamine paster (transderm scop)	Dipotassium clorazepate (tranxene)	Tranylcypromine
Te Leixiluo (trasylol)	Su Weitan (travatan)	trazec
			Trazodone hydrochloride (trazodone)	Trazodone hydrochloride (trazodone hydrochloride)	Ethyl pyridine carbon thiamine (trecator)
Triptorelin pamoate (trelstar)	Pentoxifylline (trental)	Treprostinil that sodium (treprostinil sodium)
			Tretinoin (tretinoin)	?trexall	triacelluvax
TA (triacet)	?triacin-c	Triamcinolone acetonide (triamcinolone acetonide)
			Triamcinolone hexacetonide (triamcinolone hexacetonide)	Ademine (triamterene)	Triazolam (triazolam)
tricor	Three-in-one barrier cream (triderm)	Tridesilon (tridesilon)
			Trimethadione (tridione)	Thiethylperazine (triethylperazine)	The trifluoro pyridazine
Trifluoro pyridazine hydrochloric acid	Psychoperidol (trifluperidol)	Triflupromazine (triflupromazine)
			Trifluridine (trifluridine)	Fenofibrate (triglide)	Benzhexol (trihexyphenidyl)
Benzhexol hydrochloride (trihexyphenidyl hydrochloride)	Oxcarbazepine (trileptal)	Three fine jade agates, fluocinolone acetonide (tri-luma)
			trilyte	Alimemazine (trimeprazine)	Trimethobenzamide (trimethobenzamide)
Trimethobenzamide hydrochloride (trimethobenzamide	Trimethoprim (trimethoprim)	Trimethoprim (trimethoprim sulfate)

hydrochloride)
			Trimetrexate (trimetrexate glucuronate)	Trimeprimine (trimipramine)	Amoxicilin trihydrate (trimox)
Trinipatch nitroglycerin organic nitrate	?tri-norinyl	triostat
			D-Norgestrel (triphasil)	?tri-previfem	Triprolidine hydrochloride (triprolidine hydrochloride)
Two hydroxyls are love song Pu Ruilin (triptorelin pamoate) how	Arsenic trioxide (trisenox)	Norgestimate ethinylestradiol (tri-sprintec)
			tritanrix?hepb	?trivagizole	trivora
Three associations are (trizivir) only	Trobicin (trobicin)	Tromethane (tromethamine)
			Taurine (trophamine)	?tropicacyl	N-ethyl-N-(.gamma.-picolyl)tropamide (tropicamide)
Tropisetron (tropisetron)	?trosec	trudexa
			Truphylline (truphylline)	The diindyl azoles draws amine (trusopt)	Emtricitabine (truvada)
Tryptophan	?tussigon	Tussionex (tussionex)
			twinject	Twinrix (twinrix)	Tigecycline (tygacil)
Taylor's promise (tylenol)	?tylox	Natalizumab (tysabri)
			Tetrahydrozoline hydrochloride (tyzine)	The u-cort hydrocortisone	Sevoflurane (ultane)
The ultiva remifentanil	Acetaminophen, tramadol hydrochloride (ultracet)	Ultram (ultram)
			ultratag	Ultratard (ultratard)	ultra-technekow
Halobetasol propionate (ultravate)	Ultravist (ultravist)	Unasyn (unasyn)
			uniphyl	Hydrochlorothiazide (uniretic)	unisom
Levothyroxine sodium (unithroid)	Moexipril (univasc)	Uprima (uprima)
			Carbamide (urea)	Ureaphil (ureaphil)	Choline (ure)
Hippuric acid bird Lip river tropine (urex)	Urispas (urispas)	Urocit-K (urocit)
			Urofollitropin (urofollitropin)	Urokinase (urokinase)	Urinary system (urologic)
uromax	?uroxatral	urso
			ursodiol?C24H36O4D4	Wa Desi (uvadex)	vagifem
Tioconazole (vagistat)	Valganciclovir (valcyte)	valdyn
			Stable (valium)	?valnac	Sodium valproate (valproate sodium)
Valproic acid (valproic acid)	Valproic acid (valproicacid)	Valrubicin (valstar)
			Acyclovir (valtrex)	?valtropin	Norvancomycin hydrochloride (vancocin hydrochloride)
The vancomycin vancomycin	?vandazole	Eflornithine hydrochloride emulsifiable paste (vaniqa)
			Vaniqa Eflornithine hydrochloride emulsifiable paste	?vanos	vantas
Cefpodoxime (vantin)	Vaprisol hydrochloric acid conivaptan injection	Vardenafil Ai Lida

Vaseretic (vaseretic)	Pathocidin (vasocidin)	The vasocon naphazoline
			Puli (vasotec)	vasovist	Vecuronium bromide (vecuronium bromide)
Potassium v calcium (veetids)	Ten thousand Mactra sulcatria Deshayess (velcade)	Desogestrel (velivet)
			Cefradine (velosef)	Velosulin (velosulin)	Venlafaxine (venlafaxine)
Wei Lefu (venofer)	QIANLIETONG PIAN (ventavis)	Breathe heavily happy peaceful (ventolin)
			?venvia	Etoposide (vepesid)	Verapamil
Verapamil hydrochloric acid	Verelan (verelan)	Nofetumomab (verluma [nofetumomab])
			Verteporfin (verteporfin)	Tretinoin (vesanoid)	vesicare
Rimexolone (vexol)	Voriconazole vfend	The viadur leuprorelin
			Viagra (viagra)	vibisone	Doxycycline (vibramycin)
Vibration label (vibra-tabs)	Wei Keding (vicodin)	vicoprofen
			Azacitidine (vidaza)	Wei Tai (videx)	Ammonia hexenoic acid (vigabatrin)
?vigamox	Viloxazine (viloxazine)	Vinblastine sulfate (vinblastine sulfate)
			Vincristine sulfate (vincristine sulfate)	Vinorelbine (vinorelbine)	Vinorelbine tartrate (vinorelbine tartrate)
Hydrocortisone. (vioform hydrocortisone)	Viracept see nelfinaivr (viracept)	Interferon Alpha-2b (viraferon)
			?viraferonpeg	Nai Weila (viramune)	Virazole (virazole)
The viread tenofovir	Virilon (virilon)	Trifluridine (viroptic)
			Wei Si cool film (visicol)	Visine (visine)	visionblue
?visipaque	Visken (visken)	Vistaril (vistaril)
			Cidofovir injection (vistide)	Tie up fast Da Er (visudyne)	Retinoic acid (vitamin a acid)
Vitamin A palmitate (vitamin a palmitate)	Vitamin D (vitamin d)	Vitamin K1 (vitamin k1)
			Hyaluronidase (vitrase)	Ganciclovir (vitrasert)	vitravene
Protriptyline (vivactil)	vivanza	vivelle
			Voltaren (voltaren)	voluven	Voriconazole (voriconazole)
?vosol	vospire	Teniposide (vumon)
			Be the compound medicines of simvastatin (simvastatin) and these two kinds of medicines of ezetimibe (ezetimibe), every ... that Vytorin is that first also is only one and can comes the medicine (vytorin Vytorin) of cholesterol reducing level by two kinds of approach so far	Warfarin sodium (warfarin sodium)	welchol

Amfebutamone (wellbutrin)	Pine valerate (westcort)	wilzin
			wygesic	Anagrelide (xagrid)	Xalatan (xalatan)
Xanax (xanax)	xapit	Alfuzosin hydrochloride slow releasing tablet (xatral)
			Xeloda (xeloda)	Orlistat (xenical)	Xenon (xenon)
Duloxetine hydrochloride (xeristar)	Bromfenac eye drop (xibrom)	Rifaximin (xifaxan)
			xigris	Genentech monoclonal antibody medicine (xolair)	Levalbuterol (xopenex)
x-trozine	Lidocaine (xylocaine)	xyrem
			Excellent think of bright (yasmin)	Duloxetine (yentreve)	Yohimbine
ytracis	yttriga	zaditor
			Zafirlukast (zafirlukast)	Zalospirone (zalospirone)	zanaflex
Zanamivir (zanamivir)	Streptozocin-(zanosar)	Ranitidine (zantac)
			Ethosuximide (zarontin)	Metolazone (zaroxolyn)	zartra
zavesca	Zebeta	Lamivudine (zeffix)
			Omeprazole (zegerid)	Tegaserod (zelnorm)	The sharp ostelin injection (zemplar) of handkerchief
zemuron	Zenapax (zenapax)	zerene
			Sai Ruite (zerit)	Zestoretic	Lisinopril (zestril)
According to Ezetimibe (zetia)	Cetuximab (zevalin)	Bisoprolol (ziac)
			Film coated tablets (ziagen) is advanced in match	Ziconotide (ziconotide)	Zidovudine (zidovudine)
Zileuton (zileuton)	Zimor	Zimostatine
			Rimonabant (zimulti)	Zinacef (zinacef)	Zinc chloride (zinc chloride)
The enemy draws and makes can loose (zinecard)	Ziprasidone (ziprasidone)	Ziprasidone (ziprasidone mesylate)
			Zithromax (zithromax)	zmax	Simvastatin (zocor)
Ondansetron (zofran)	Nuo Leide (zoladex)	Zoledronic acid (zoledronic acid)
			Zomitriptan (zolmitriptan)	Zoloft (zoloft)	Zolpidem (zolpidem)
Select Thailand (zometa)	Zolmitriptan (zomig)	Zonalon
			Zonegran	Zonisamide (zonisamide)	Zopiclone sheet (Zopiclone)
Zorbtive	Merck experimental vaccine (zostavax)	Sodium-tazobactam (zosyn)
			Zotepine (Zotepine)	Themgran Junior children's chewable vitamin tablets (Zovia)	Shu Wei treats (Zovirax)
Zuclopenthixol (zuclopenthixol)	The class of carrying (zyban)	Zileuton (zyflo)
			zylet	Zyloprim	Zymar
Zyprexa (zyprexa)	Zirtek (Zyrtec)	Linezolid (Zyvox)

Above-named multiple medicine is being studied at present and is being used to be transported to the lung tree.Following discussion provides specific examples, but does not carry relevant medicine all to be included what develop rapidly with lung.Medical port device disclosed by the invention and carrying method will be carried the clinical medicine that is used for any current existing of pulmonary delivery and develops in the future at present licensed or will be licensed.

Set up peptide, polypeptide and protein can conduct drugs to health through pulmonary route as effective and efficient manner remainder by research.Many in addition peptides, polypeptide and protein itself also are used for the treatment of various health status as therapeutic agent.For example, multiple proteins is studied to change metabolism at present.It is fat that American above 60% is considered to.Fat inhibin (Obestatin), polypeptide YY and body slimming element (leptin) are appetite control hormone.Human growth hormone's release peptide (Ghrelin) increases hormone for appetite.Rimonabant (Rimonabant) is new medicine, and it may can be used in the new medicine of obesity.Cannabinoid-1 (Cannabinoid-1) receptor antagonist SR141716A and opium (opioid) antagonist LY255582 are the other medicines of appetite-suppressing.Other hormones comprise that insulin preparation is studied, and imbedibility insulin (exubera) the also form utilization being suitable for absorbing recently.Fall (blood) calcium element and be can suck and can treat osteoporosis, hypercalcemia and Paget.Follicule-stimulating hormone (FSH) (FSH) is to treat sterile hormone.Auxin can be treated growth retardation.Thyrotropin (TSH) can be treated the hypothyroidism that causes tired and weight increase.Other hormones that the conduct of studying sucks form comprise Somat and parathryoid hormone.LHRH (interstitialcellstimulating hormone (ICSH)-releasing hormone) but comprise antagonist and the absorpting form of antagonist all is being studied and is used for osteoporosis.Imbedibility phosphodiesterase-5 inhibitor that is used for erection disturbance also is studied.Vassopressin (Vassopressin) analog is used to treat many cardiovascular disease.Immunoglobulin is used to treatment and infects, and can be customized and offer in the future the patient with treatment specified disease or disorder.These have all represented the therapeutic agent based on proteins/peptides likely that is used for various diseases and state, and based on preliminary study, but inhalation route can be to carry the unique of these medicines or effective and efficient manner.

Medication disclosed by the invention also comprises the conveying of other forms of hereditary material (for example DNA and RNA) so that treat the treatment of various states such as the people's who is used to be subjected to the cystic fibrosis puzzlement lung liner (lung lining), is similar to the stem-cell therapy that is used for parkinson disease (for example attacking brain stem) and diabetes (for example attacking the islets of langerhans of Langerhorn).Another kind comprises that the medicine of hereditary material is that trade mark is Pulmozyme ^TMα-deoxyribonuclease streptodornase, recombinant dnase, recombinant human deoxyribonuclease, it is the enzyme that is used for cystic fibrosis etc. to reduce the generation by the infection of the hydrolysis DNA of viscosity sputum.The interleukin-11 of absorpting form is being studied and is being used for the treatment of asthma.The interferon therapy agent is being studied and is being used for multiple sclerosis and hepatitis B and hepatitis C.The emophysematous original position gene therapeutic agents that is used for the treatment of tumor specificity antiapoptotic inhibitive factor (Survivin) gene therapeutic agents of pulmonary hypertension and hHa1P1 (people α-1 protease inhibitor) or reduces some types also is studied.The gene therapeutic agents that is used for treatment of cancer or prevention also is studied.Example comprises that replacement is used for the aerosol gene therapeutic agents of the p53 gene therapy of pulmonary carcinoma, and the treatment that is used for the suction cytotoxic drugs (chemotherapy) of pulmonary carcinoma.

According to method disclosed by the invention be used for carry the typical protein of media can be the data base who keeps by UniProt Consortium Http:// www.pir.uniprot.org/Find in (on January 26th, 2006) that it is incorporated among the application by all quoting.But being used to of being used for that gene therapy and/or other treatment use carries the typical polynucleotide infra column data storehouse of media to find: Http:// www.ebi.ac.uk/embl/index.html((on January 26th, 2006) (RNA/DNA sequence) (and the EMBL nucleotide sequence database is also referred to as EMBL-Bank, by (the European gene information EBI of association) keep and by (U.S.'s gene database and Japanese DNA data base (DDJP) cooperation produce) and Http:// imgt.cines.fr/IMGT GENE-DB/GENElect? livret=0(on January 26th, 2006) (immunoglobulin and TXi Baoshouti gene) is (by international immunogenetics information system (International ImMunoGeneTics Information ) keep), these data bases are attached among the application by all quoting.Lipid also can be carried by method disclosed by the invention through pulmonary route, but finds in the typical lipid infra column data storehouse: Http:// www.lipidmaps.org/data/structure/index.html(on January 26th, 2006), it is kept by lipid metabolism approach project and data (LIPID MAPS), and it is attached among the application by all quoting.

The gas that sucks is can be through the another kind of medicine of system and method conveying disclosed by the invention.Nitric oxide usually is used as anesthetis.Helium-oxygen gas mixture is used among the patient who suffers from the respiratory distress puzzlement.

Multiple antibiotic is being used as inhaled medication research.As mentioned above, tobramycin has been proved and has been used for sucking.Penicillin, quinolones (ciprofloxacin), aztreonam and be used for pulmonary and other antibiotic of systemic infection evaluated.The immunoglobulin of suction form (antibody) is also assessed in infection and/or inflammatory conditions.Filgrastim (GCSF) makes immune system obtain increasing, and the form that sucks is available.

The central nervous system (CNS) who sucks medicine uses and also is studied.Nicotine can utilize in a variety of forms, but advantageous use has been advised in the application of the application's medical port and carrying method and to habit-forming the substituting and be not exposed to the carcinogen of tobacco product of Nicotiana tabacum L..The suction medicine of treatment migraine and be used for that suction tranquilizer such as the morphine of acute or chronic pain treatment also utilizes.Other CNS medicines of studying comprise peace peach happy (by the suction analgesic of nitrous oxide and oxygen combination) and suck antianxiety drugs.

Other new different pharmaceuticals also can be transported to the lung tree.It is favourable that cyclosporin A (organ-graft refection's medicine) has been reported in the suction form recently.A-1 antitrypsin therapeutic agent is being studied the treatment that is used for emphysema and cystic fibrosis.The conveying of saline solution of twice of comparing Atlantic salinity is favourable with the suction form in cystic fibrosis patient.Differentiated some other drugs or gas and the analgesic/anesthetis of medicament, for example be used for pulmonary hypertension or be used for the analgesic nitrous oxide for sucking for the good candidate that is used for disclosed device.The anesthetis of desflurane and all " anes " families also is possible material standed for.For example, the Seattle, washingtonian Corus Pharma be studying at present be used to alleviate the chronic cough that causes by cancer or the chronic emophysematous lignocaine that sucks.Other drug comprises that antianxiety drugs is Versed such as the commercially available trade mark that is used for anxiety reduction ^TMMidazolam (nose dropping treatment that is used for child or adult is available at present), commercially available trade mark be Zomig ^TMZolmitriptan and commercially available trade mark be Imitrex ^TMSumatriptan (it can be used for the nasal spray of migraine at present); And antibiotic is such as tobramycin solution, and it comes into question in the literature at present and can suck and is used for cystic fibrosis and bronchial infection, and vancomycin, and it can't be inhaled into.Steroid medicine such as the Pumi gram (Pulmicort) that sucks ^TMAlso can be utilized at present and be the good candidate that is used to suck conveying.

The medicine that is transferred and therefore depends on mucosa absorption at present with suppository form has been represented the medicine that can be suitable for by another kind of disclosed system conveying.Described medicine based on suppository, but nonrestrictive example are for the commercially available trade mark that is used to feel dizzy with regurgitation is Phenergan ^TMPromethazine, it also can orally utilize.

At present known and other lung medicines that can be used to disclosed device include but not limited to: the prostaglandin that can suck is such as being used for neonate to proofread and correct patient's patent ductus arteriosus (bypass opening of its sealing heart); The nitroglycerin aerosol apparatus, its (ligule spraying) for the FDA permission is used for the treatment of coronary artery disease such as angina pectoris; And hydryllin such as the commercially available trade mark that sucks is Astelin ^TMAzelastine, and Desmopressin DDAVP nasal mist, its by it to the influence of kidney and as antidiuretic.

As mentioned above, some medicines can't be used for pulmonary administration at present, but they are the drug candidates that can be used for through patient's suction.These comprise, for example antarthritic of Xi Ruing and vaccine, and (for example commercially available trade mark is Flumist such as influenza nose vaccine ^TMMedicine, its at present by injection as influenza vaccines) and TB vaccine.

Be used to alleviate the medicine of flu-like symptom such as virazole (Virazole ^TM) (its can aerosol form utilization, the influence that is used to resist respiratory syncytial virus (RSV)) also advantageous particularly.System and method utilization disclosed by the invention can come by processing influenza virus such as bird flu virus in various degree is provided at present, as the described medicine of pulmonary delivery.Under first kind of situation, device of the present invention provides comfortable, is used to filter the filtration system of exotic disease substance.The second, it can be used in combination the commercially available trade mark that is used to suck with conveying with the medical port of device of the present invention is Virazole ^TMVirazole, perhaps another kind of suitable drug.The 3rd, it can (be 11/412 at application number for example with device, those that describe in 231 the U.S. Patent application, this patent application is incorporated among the application by quoting in full) be used in combination, although be used to destroy DNA, RNA or used filtration system but still enter pathogen in the air-flow at described device medium ultraviolet light.

The term of Shi Yonging " medicine " also comprises free acid, free alkali, salt, amine and various hydrate forms in this article, the above-mentioned described medicine of mentioning that comprises hemihydrate form, and the acceptable preparation of materia medica those skilled in the art of described medicine (they combine with the generally well-known adjuvant material in acceptable this area on the materia medica and make preparation, preferably do not have other additives such as antiseptic).In certain embodiments, pharmaceutical preparation does not comprise that other compositions are such as the antiseptic that can cause untoward reaction.Therefore, described preparation consists essentially of acceptable carrier (for example water and/or ethanol) on active medicine on the materia medica and the materia medica.But if medicine is not for needing the liquid of adjuvant, then its chemical formula can be represented this medicine basically, and it has enough low viscosity, can use breathing equipment atomizing of the present invention.In other embodiments, if suitable, pharmaceutical preparation can comprise acceptable carrier and/or adjuvant on one or more active component, the materia medica, and other compositions are such as but not limited to emulsifying agent, buffer, antiseptic and analog.

In this article, terms " formulation " generally refers to any mixture, solution, suspension or the analog that contains active component and carrier, and when preparation when the aforesaid breathing equipment, and have make preparation be in by malleation carry/suck/be blown into the physical property of the form in patient's lung.Active component can be the active medicine (as defined above) on any materia medica, perhaps diagnosis or imaging agents.Carrier can be to be suitable for acceptable flowable on any materia medica that activating agent is carried.Useful medicine comprises medicine defined above, be transported to the systemic active medicine of airway, and useful diagnostic agent comprises those that are used in combination with ventilation imaging.Preparation also can comprise the hereditary material that is dispersed or dissolved in the carrier, and wherein hereditary material (when in the cell the patient) is expressed reactive protein or the peptide on the materia medica.Formulation example be as being solution, for example aqueous solution, acetic acid solution, water/acetic acid solution, physiological solt solution, suspension colloid and microcrystal suspension.In an embodiment, preparation can be the drug solution or the suspension of low melting point or high-vapor-pressure propellant.In certain embodiments, preparation can solid form.The preparation of solid form comprises powder, tablet, disperse particles and capsule.The preparation of solid form can or atomize (will be described later) so that sucked by host or patient by disclosed breathing equipment evaporation.Acceptable auxiliary can be volatile or fixedness on the materia medica.When heating, volatile adjuvant and medicine volatilize simultaneously, atomize and suck.The kind of described adjuvant is known in this area, includes but not limited to gas, supercritical fluid, liquid and solid.Be enumerating of the interior typical carriers of described kind scope below: water, terpenoid is such as menthol; Alcohols, such as ethanol, propylene glycol, glycerol and other similar alcohols; Dimethyl formamide; Dimethyl acetylamide; Cera Flava; Supercritical carbon dioxide; Dry ice and their mixture.

Multiple medicine, medicine family and the therapeutic agent of studying (protein of suction, hereditary material, gas) are developed with the form of using inhalation route (nose, tracheal bronchus and alveolar region).Among the present invention disclosed medical port device and carrying method can be applicable to FDA permission, developing at present with any future can be through the medicament or the medicine of pulmonary delivery (or carry through sucking).

Said medicine and preparation are as reference present or that may pass through suction or be utilized by breathing or pulmonary system.Should be appreciated that also within the scope of the invention, and described said medicine and preparation are also carried by the nose approach by nasal passage and nose film.

Though use term medicament or medicine in the present invention, but these terms are used to comprise to have some any materials useful or therapeutic purposes widely, comprise material for example steam, physiological solt solution or be used to other materials such as chemical compound of Enhanced Imaging.

Content of the present invention

The invention provides by with medicine to carry the system and method for the respiratory system that conducts drugs to the patient who can not have assisted respiartion with respect to atmospheric malleation.In an embodiment, medicine air-flow, purify air or admixture of gas in be transferred with malleation.In an embodiment, system and the equipment that provides the suction of using purifying air of malleation to be used for medicine to carry disclosed by the invention.The present invention also provides can exact dose to carry and has sucked medicine, and can with medicine continuously or in time coordinate synchronization carry the device of medicine in patient or wearer's breath cycle.Disclosed here device and system are configured to be easy to mode with efficient, controlled and the targeting space with the pharmacological preparation air in lungs that is transported to the patient without lifting an eyebrow in purifying air.

Disclosed by the invention providing is used for the breathing apparatus of drug administration to the media of user.The present invention also provides and has been used for sucking method and system with whole hosts' drug administration via the patient, before described comprising without the medicine of inhalation.

In the embodiment of system and method for the present invention, device conducts drugs to the patient, and wherein the patient can breathe under the outside auxiliary situation not having, and does not therefore need the breath cycle that external breathing is auxiliary or interfere receiver self.This is opposite with the force ventilation equipment that constitutes external assisted respiartion.As less extreme example, be designed to treat, such as continuous forward airway pressure (CPAP) machine of sleep apnea, take place at need in case breathe, all must get involved breathing pattern, thereby also constitute assisted respiartion with the correction patient.Another example of assisted respiartion comprises the form of non-external ventilation (NIV), and it is used to suffer from serious breathing problem and those are not having the patient that the experience dyspnea perplexs under the auxiliary situation, and generally is the final step before the tracheal intubation.Do not needing the extra input of patient one side to breathe, and providing some auxiliary whiles by malleation for user, device of the present invention is not configured for external assisted respiartion or interferes the device of patient's breath cycle.

In this article, it is auxiliary that " invasive assisted respiartion " refers to the breathing of the respiratory mechanism of require interfering the patient, such as by intubate (be used to generally call inhale auxiliary) or proofread and correct erratic breathing pattern, or by the patient's use that self can not fully breathe.Though not as the such active of intubation, CPAP and NIV belong to the kind (as using in the present invention) of invasive assisted respiartion.So, invasive assisted respiartion method and apparatus typically adopts the pressure higher than apparatus and method of the present invention.

On the contrary, " the no assisted respiartion " used in this article refers to the ability of helping just can fully breathe such as the help that is provided one of by above-mentioned " invasive assisted respiartion " method or in installing (for example having the blood oxygen level in normal range) not outside.In an embodiment, apparatus and method disclosed by the invention are used for not having the patient of assisted respiartion.Therefore, typically, the pressure that adopts in apparatus and method of the present invention will be than being used for desired those the lower or littler initiatives of invasive assisted respiartion, such as respirator or NIV or CPAP machine.In an embodiment, medicine is approximately 1cm H at pressure ₂O is to about 30cm H ₂The air of O, purify air or admixture of gas in be supplied to.Typically, the pressure that adopts in device of the present invention is low can distinguish on the basis of the pressure of machine supply to the breathing pattern that is enough to make the patient beginning of breathing (for example air-breathing and).

Though apparatus and method of the present invention are used for not needing to breathe auxiliary spontaneous respiration patient, apparatus and method of the present invention in certain embodiments can be used in combination with respirator medicine is sent to the oxygen uptake patient.For example, the application number that also comprises disclosed by the invention is 11/533,529, is entitled as the respirator of describing in the U.S. Patent application of " Respirators for Delivering Clean Air to an Individual User (carrying pure air to give the breathing machine of individual user) " (it is attached among the application by reference) and is used in combination with equipment disclosed herein.System and method of the present invention also uses the height of pulmonary to absorb the approach of liner as the administration high amount of drug fully, safely effectively.

Medicament delivery method of the present invention also can use existing respiratory system to implement.Scope from the face shield that covers oral cavity and nose a large amount of air supplied masks to the face shield that covers entire face to the nostril, oral cavity (as portable underwater respiratory organ (SCUBA) instrument existing those) can implement by disclosed in an embodiment medicament delivery method.

In certain embodiments, the pure air of supply can reach (with to filter surrounding air opposite) by synthetic mode, such as by will be from the mixing of liquid oxygen, liquid nitrogen and liquid carbon dioxide.Particularly, provide a kind of system in an embodiment, comprise aerator for example pump or hair-dryer or the system of air is provided under pressure, SCUBA jar for example is to produce the air-flow of clean air.Many active respirators are known, for example the positive pressure respirator of being made by 3M (PAPR); By the continuous positive airway pressure respirator (CPAP) that some medical suppliers such as Puritan Bennet and Respironics makes, it comprises and typically covers the pressurization face shield that nose is used to solve the sleep apnea problem; The fire control type face shield that is connected with chemical air filtering system; And the face shield that is connected such as the SCUBA instrument that is used for diving under water under water with compression cylinder.As discussed above, in some embodiments, medicament delivery device disclosed in this invention can use described one type of prior art syringe to implement.But, the air of the high purification in pressurized canister, existing air supplied mask can not provide the air less than the high purification of 20 nanometers and combined with ozone removal typically, this means that chemical constituent may be subjected to airborne pollutant effects in some environment Chinese medicines.Therefore, to use in conjunction with superincumbent application number be the respirator of describing in 11/533,529 the U.S. Patent application for method and system of the present invention in some preferred embodiments.

See though stand on the position that the environmental stimulus thing of pulmonary and other organs is eliminated, destroy contaminants itself can be considered to favourable to user from air, find that but further detect the typical open-air particularly chemical compound of room air has disclosed the drug conveying particular importance that purifies air for guaranteeing through the effective and safe of pulmonary route.The importance that purifies air that is used for system and method for the present invention is by being formed in the high concentration of surrounding air normal presence and the microgranule of chemical constituent.Though granule amount changes in very wide scope based on the specific background environment, room air can be easy to contain every cubic metre and surpass 10,000,000,000 microgranule, and wherein many microgranules have the scope of diameter less than 20nm.In addition, consider that these microgranules belong to the probability of inert particulate though exist, the droplet that is condensed to the organic or inorganic chemical compound or the crystallite microgranule of the big percentage ratio of these microgranules comprise such as chemical compounds such as aromatic hydrocarbons and carbon particulates.

The chemical constituent of the pollutant in the prediction room air is further complicated owing to the existence of ozone.Though itself belongs to noxious pollutant ozone, it also has the height reactivity.The reaction of ozone and other organic pollutions causes the generation of a large amount of derivative compounds, these chemical compounds have carried out part Study (mechanism that smog forms etc.) concerning outdoor air, but do not obtain well proving and can not being understood widely under indoor environment in present document.Because the reason of polymer (carpet, interior decoration etc.) venting or simply owing to use clean cpd, other Organic substances also are found in room air.Being proved a type organic that enlivens especially when forming derivative compound in air when exposing with ozone is terpenoid, and it uses in many cleaning agent and air freshener, is the fresh Masson Pine of many cleaning products or the main component of Fructus Citri Limoniae abnormal smells from the patient.Terpenoid is used sometimes as the carrier mass (menthol is an example) that is used for medicine.

In addition, the solid or the chemical compound of liquid form on macroscopic view, many chemical reactions can carry out slowly relatively.But, be everlasting senior middle school and college chemical experiment chamber as usual proved like that, the high surface volume ratio has increased the response speed between two kinds of chemical compounds.Because many atomizing contaminant particles are in the scope of 20nm, microgranule has very large surface-to-volume than the rapid generation that can make reaction

Special concern, the field of the chemical reaction of not expecting between relevant medicine and environmental contaminants is the pulmonary delivery that protein and polypeptide comprise gene therapeutic agents.As be entitled as " Protein Oxidation at the Air-Lung Interface (protein oxidation on gas lung interface) " at F.J.Kelly and I.S.Mudway, as described in the survey article of Amino Acids (2003) (being incorporated into the application by quoting in full), some are not expected, and to be reflected between protein and reactive oxygen or nitrogen kind such as ozone or the nitrogen dioxide be known.As explaining in this article, reactive oxygen and nitrogen kind and their secondary lipid and glycosyloxy product can with protein interaction, induce reaction and modify such as the oxidation of proteinic polypeptide backbone, peptide bond fission, protein-protein cross and amino acid side chain within the specific limits.Aromatic amino acid (for example tyrosine, tryptophan, phenylalanine) and aliphatic amino acid (for example arginine, lysine, proline and histidine) can be called the target of reactive oxygen and/or nitrogen kind, two kinds of sulfur-containing amino acid: cysteine and methionine seem especially responsive to oxidation.

The existence of organic and inorganic pollution and reactive chemical, high particle number, ozone and since the uncertain derivant that the ozone and the reaction of other chemical compounds cause combine the feasible chemical constituent that is difficult to predict air.Have a negative impact or form a large amount of chemical compounds that may cause insalubrity owing to can form effectiveness to medicine itself, medicine is incorporated into the probability that has greatly increased side effect in the air that not have abundant purification.Therefore, it is preferred purifying air for carrying method of the present invention.

Since the particle number in the surrounding air be determined as in the urban district sometimes every cubic metre surpass 10,000,000,000 and particle size less than 20nm, must think over filtration.Be used for filtering (filter efficiency is 99.97% under the 300nm) for the HEPA level before the standard mesh of most of user, occupational and medical filter device, for the every cubic metres of air that is filtered and Yan Qike allows to pass through above 10,000,000,000 microgranules.

In order to ensure the effective filtration that can eliminate the potential adverse reaction thing that produces by the chemical compound of high concentration unknown airborne and drug reaction, filter material and all filters design boths should carefully be selected.The filter material that can satisfy these efficient (for example 6850 of Lydall Filtration grades) can be easy to buy.This technology has been widely used in the equipment equipment such as clean room, but it is being used for the less application of breathable air, does not all see in all any documents that uses as described in this article in this technical field.Should be understood that it is that its principle is used that this material is used for clean room, and wherein the quick variation of space air also is its typical application, in most of the cases above-mentioned high efficiency filter material is designed to have higher flow velocity.In this high flow rate was used, air passed through filtering material with higher relatively speed.Therefore, contaminant particle clashes into filtering material with higher relatively speed in this application.The speed of particle breakthrough depends on the kinetic energy (1/2mv of microgranule to a great extent ²), and particle breakthrough increases along with increasing of speed.This speed is called as " cover wind speed " (face velocity) in filter industry.The chart of Figure 22 shows for the relation between the efficient of material such as above referenced material and the cover wind speed.

Obtaining maximum filtering efficient based on this relation for above-described filtering material will utilize relatively low cover wind speed to reach.Under given flow velocity, cover wind speed and filter area are inversely proportional to.Therefore, use disclosed by the invention than the bigger area of required area satisfying in order to obtain the pressure drop requirement of low microgranule speed, thereby very high efficient is provided, this for medicine with purify air that to combine be important.Simultaneously, realized being equal to or higher than the flow velocity of existing apparatus.

As mentioned above, when the cover wind speed is reduced under the 2cm/sec, (ULPA level filter is such as from LydallFiltration/Separation for filter efficiency in this scope and representative glass microfiber technology, Inc., Rochester, those of NH) be implemented, and 100% efficient is implemented when it reaches about 1cm/sec.In a preferred embodiment of the invention, the air velocity to user is approximately 320slm.Because the indoor and outdoors particle concentration surpasses every square metre 10,000,000,000 sometimes, filter efficiency should be very high to guarantee that unnecessary chemical reaction does not take place between microgranule and medicine.This is for having high surface than particular importance the small particle (for example less than 100nm) of (surface to area).As mentioned above, the chemical combination composition of microgranule will take place to change greatly as the function of position weather etc.Therefore, the elimination of the reactant that these are possible is important, so that be sure of the final conveying of medicine (chemical substance).Also as discussed above such, existing respirator has been realized the filter efficiency of about 99.97% under the 300nm.Since the room air particle concentration is approximately every cubic metre 10,000,000,000 and during tranquillization pulmonary's respiratory volume reach about 5 liters, about 99.97% filtration means that existing respirator allows each the breathing to surpass that 10,000 5 thousand sizes equal microgranule that diameter is 300nm and 150,000 sizes are approximately 25nm and littler microgranule passes through, for wherein having created environment by unsafe chemical substance of the generation of the interaction between the medicine of these high particle concentrations and injection.

System of the present invention has reached the height credible (for example filtering about 99.9996%) of carrying the chemical constituent aspect of medicine.Use above-described preferred embodiment, for the filtration of this level, filter area typically can surpass about 500cm ²About 2700cm in the scope of filter area ²To 5400cm ²Filter area can be utilized, can reach about 99.99996% and about 99.99999% filter efficiency respectively, and each only breathe that hundreds of microgranules can correspondingly pass through.In another embodiment, use the flow velocity (breathing for the adult under the tranquillization is enough) that is approximately 160slm, 99.9996% efficient can be used and be low to moderate about 250cm ²Filter area realize, and for approximately greater than 2700cm ²Area can reach maximal efficiency.In another embodiment (Figure 21), adopt air bag 21002 standby to keep filtered air.In this embodiment, a large amount of instantaneous peak value breathing rates (approximately 500slm) can be by being protected far below the filtration under the Mean Speed.The air that supplies to user through medical port 21003 and flexible pipe 21004 is stored by hair-dryer unit 21001 in the user exhalation process.In this mode, the unitary size of hair-dryer need be minimized.Keep one than the little flow velocity of mean flow rate by filter, filter efficiency can reach maximization, for example, uses about 830cm ²Filter area can realize the about 50slm of mean flow rate, 99.99999% filter efficiency.

In air, exist and since the filtration of the particle matter that the result of the reaction between organic fine particles material and the ozone forms significantly improve; But ozone can not remove by filter and will be retained in the filtered air as pollutant as the material of molecular level by simple and mechanical.Therefore, need in certain embodiments to remove, wherein ozone is changed into molecular oxygen or change into harmless or reactive other chemical compounds lower than ozone by reaction or catalytic step.The method that is used to reduce or eliminate a kind of easy utilization of ozone is the use of active carbon filter.This method is by realizing when air absorption ozone by by big surface area activated carbon the time.Absorbent charcoal material can be implanted in the filter material or as an alternative, remain between the two-layer filter material with microgranular form.But because the gathering of absorbing material and the filtration chemical compound that produces on carbon surface, As time goes on the performance of active carbon filter reduces.Filter must often be replaced.Therefore, preferred embodiment comprises catalyst, and its help finally changes into O with ozone ₂MnO ₂(γ-MnO ₂And β-MnO ₂Both) and palladium or Palladium monoxide, Ag ₂O or other metal-oxides such as aluminium oxide and/or copper oxide can be used as catalyst, and can be applied in as the lip-deep coating of conveyer device that contacts with air-flow.Material also is incorporated in the filter material itself by implanting or catalyst particles being connected to filter fiber substrate.In exemplary embodiments, catalyst is incorporated in the chemical composition of glass fibre of filter.

Use MnO ₂Another advantage as catalyst is that designed chemical substance is for the SO that removes as another kind of main air pollutants ₂Also be useful.Another kind of common pollutant NO ₂Can use the catalysis of different chemical material and import some energy to drive reaction.An example is when being exposed to TiO ₂Irradiating surface the time nitrogen oxide photocatalysis.Therefore, the additional embodiments of method and system of the present invention comprises that use also effectively removes ozone, SO ₂And NO ₂One or more purify air.

The present invention further provides the method and system that is used for medicine or medicament are supplied to air flow, thereby carried medicine through eupnea.These are different with other similar devices with Evohaler, and the operation of those devices requires user to pay and participates in sucking some other strength of circulation and extra coordination power.Typically, medicine offers the patient with solid, microgranule or powder type and with tablet or capsule administration, and perhaps medicine provides and oral (for example cough syrup) with liquid form, perhaps is expelled in the muscular tissue or intravenous injection.Other drug and then dependence postpone or release mechanism, such as depending on the ointment that absorbs through skin.Oral, injection, intravenous and percutaneous carrying method all have distinct disadvantage.For the oral delivery of medicine, owing to exist the medicine must be correctly and the requirement of the chemical reaction of digestive system, these distinct disadvantage must be overcome.In addition, in case absorbed by digestive tract, another obstacle that enters blood flow is the metabolism that at first needs by liver.The distinct disadvantage that injection and intravenous are carried is the invasive of method and the misery of itself bringing, the risk of infection and the psychological impact of acupuncture.Though for example the nicotine appropriateness is effective for some absorbable medicines, is not the effective means of carrying most drug through transdermal administration.

The pulmonary delivery of medicine has been avoided all these problems.The medicine of carrying by this approach is not subjected to the influence of the complicated factor of digestive tract chemical substance, and medicine has been avoided liver and absorbed by pulmonary, therefore is not subjected to the metabolic influence of the first order as the oral delivery medicine.The pulmonary delivery right and wrong are invasive, do not need pin or surgical operation.Be well known that the lung film liner of giving large surface area and sensitivity at medical domain, can be so that pulmonary delivery be to make medicine enter the rapid effective and efficient manner of blood flow.

System of the present invention be precise monitoring filtration and the pressure of dosing air and the ability of flow parameter to user to be supplied on the other hand.The conveying of existing apparatus typically depends on user must supply to air medical container or jar, that stable source is arranged from the dosing aerosol by his effort absorption, perhaps depend on system such as the Evohaler (for example, the albuterol jar must be compressed to coordinate with inspiratory phase) that requires user oneself to exert oneself to carry.On the contrary, embodiments of the invention adopt the electronic sensor and the processor active monitoring of state-of-the art and respond the breath cycle of user.Solid-state pressure transducer array is such as by Silicon Microstructuresof Milipitas, and the SM5600 series sensor that CA produces is used to monitor the pressure state in the medical port.Data from pick off are monitored in real time by the airborne microprocessor that is stored in from data collected.By this data analysis, processor can based on approximate one minute or two minutes valuable data be set up or the baseline respiration parameter of " study " user.In case baseline parameter is established, then processor can produce appropriate reaction to the specific (special) requirements and the breathing pattern of user.As a kind of example, processor can be observed pressure reading quick especially or deeply suction circulation of (large volume) with monitoring when breath cycle begins.By this way, processor can make the medicine of the amount that the hole will accurately be controlled inject air-flow with the accurate correct moment, so that its darkest ground is also sucked by user effectively.In another case, only administration in replacing suction process of medical treatment port when controlling by processor.Processor can be similar to the ink-jet printer that is used for private computer and receive mode from the data of Inkjet Cartridge and receive input from " accurately " medicine box.These data can be used to the processor indication optimal parameter about the conveying that is used for medicine and patient determined by pharmacists doctor.Described data can comprise dosage information, along with correct timing of the dosage of user breath cycle or the like.In one embodiment, medical port has digit punch, and it can be connected with device so that carry feedback about the user state.As an example, the blood oxygen saturation detector is used to monitor the oxygen content of user and medicine is made suitable response.

Be significantly, if necessary, contain the medicine air can also accurately mix and successive mode be transferred.Another unique application is to be used for slowly also accurate conveying to can be used as the medicine (such as carrying albuterol by inhaler) that regular pill is transferred at present.The slow side effect (such as " nervous " relevant) of carrying the permission patient to receive more suitable dosage gradually and can not produce of medicine such as albuterol owing to the unexpected injection of medicine with Evohaler and aerosol apparatus.For the medicine of considering, existing apparatus can't show accurately also suitably, and the ability of accurately carrying the medicine that sucks in the breath cycle process constantly.The invention provides the particularly method and system of pulmonary of the respiratory system that is used to allow medicine to be administered into the patient, described in addition method and system also reaches optimum efficient by monitoring breath cycle and controlling administration time, by monitoring and control medicine is carried out administration.By provide medicine in the air-flow that purifies and with positive pressure environment, system and method for the present invention also makes to become for breathing the limited crowd of strength finite sum breathing coordination and is more prone to, such as child or old man, with more effectively administration.

Except removing unwanted pollutant and effectively carry the medicine, the present invention allows to be supplied to the temperature and humidity of the air of user can be controlled, guaranteed to be used in the level of comfort of the most effective state of drug conveying and user.This uses by temperature and relative humidity sensor by control, such as at present can be available from Chandler, and the Humirel of AZ, the HTS2030SMD of Inc., the data of generation are finished.The temperature that determines whether to need to increase humidity or dehumidifying or rising/reduction air-flow is brought in the output of monitoring control devices pick off.Controller can start proper temperature then to be regulated.Temperature can be used thermoelectric refrigerator/heater or resistance heater to raise or reduce to change temperature.It also can start steam is injected air-flow to increase humidity.Humidity also can reduce as dehumidizer by using auxiliary condenser or exsiccator.

A kind of embodiment utilization be 11/533,529 United States Patent (USP) at application number in those similar active face shields of describing, this patent application is attached among the application by hereby incorporated by reference, and shows in Fig. 2 A and 2B.This system utilizes aerator to produce air-flow.As showing in the front view of Fig. 2 A and 2B, this system comprises the air feed shell 2400 with the centrifugal blower 2402 that is covered by prefilter 2404.Prefilter 2404 prevents that aerator 2402 from sucking too much big microgranule.Radially outward discharge and form passage by the shell wall through main particulate filter device 2410 from the air of aerator 2402, described main particulate filter device is installed in set of cells 2412 tops or is adjacent.Air leaves through outlet 2420, and this outlet is connected with face shield 2422 by supply hose 2424.For easy to use, the shell with its aerator, filter and power can " purse " mode (fanny-pack) be connected with user by belt 2430.Except that said elements, the embodiment that shows in Fig. 2 comprises that the medical treatment that is used to introduce medicine 2442 enters hole 2440, and it is an aerosol can in this example, as is generally used for albuterol is administered into the aerosol can of asthmatic patient.

Medical treatment entry port 2440 also can be known as medical port 2440.Medical treatment port 2440 comprises the hose adapter shell 2450 with air inlet 2452 and gas outlet 2454.In one embodiment, each be provided with seal arrangement in air inlet 2452 and the gas outlet 2454.In one embodiment, be sealed into have three parallel annular ridges sealing gasket so that more reliable sealing to be provided.Shown in this embodiment, medical port 2440 is connected in the flexible pipe 2424.Therefore part flexible pipe 2424 is connected with gas outlet 2452,2454 boths with air inlet.Among other embodiment that are discussed below, one of the inlet end of medical port and flexible pipe 2424 or outlet side are connected.Can support the use of medical port at the inlet end of flexible pipe though be easy to use, make user can be easy to the action of seeing that he or she does, typical preferred is especially under the situation of spraying medicine, to make the as close as possible face shield of medical port.This has been avoided medicine to condense along hose wall, and any chemical reaction with tube material is minimized, and described reaction can cause that pipe is degenerated or cause that unwanted polymer soaks from pipe and be drawn onto in the air-flow.Particularly, in the embodiments of figure 3, two pipe adapters (being also referred to as adapter shell) are shown: a downstream that is positioned at flexible pipe, and wherein it is connected with face shield 2422, a upstream extremity that is positioned at flexible pipe, wherein it is connected with shell 2400.

In the embodiments of figure 3, two hose adapter are respectively by Reference numeral 3500 and 3502 expressions.Medical treatment port 3510 and 3512 all part illustrates mixing chamber 3520,3522.As shown in the embodiment of Fig. 3, adapter shell 3500,3502 and partially mixed at least chamber 3520,3522 are connected in the system.When not in use, obsolete adapter shell 3500,3502 and obsolete mixing chamber part 3520,3522 can be come capping by the import end top that seal cover is arranged on mixing chamber part 3520,3622.Such seal cover shows in Fig. 6 and 7.In one embodiment, medical port removably is connected to flexible pipe and face shield or the shell 2400 of supplying gas such as medical port 3510,3512.In order to guarantee that medical port correctly connects, an end can have the female thread connection and the other end is that external screw thread connects, as shown in Figure 3.

As becoming clearer by following explanation, medical port is as the media that is used for the medicine of steam or Sprayable is incorporated into the air-flow that is formed by aerator 2402.This medicine is fed to user or drug administration is arrived user through flexible pipe 2424 then.The face shield that is used to this purpose is preferably the face shield that is complementary with user to carry out accurate pressure and flow assay and allows to carry out dosage control therefrom allowing.And some embodiment can be included in face shield or flexible pipe or the system Anywhere pressure transducer to measure the loss of the malleation of not expecting in the indicator (vision and audition) in the face shield.In the embodiment of Fig. 2, visual alarm 2700 and audio alarm device 2702 are set on the shell 2400.In fact, such face shield also can in addition when being not used in when medicine carried out administration, in Polluted area, use.The system of Fig. 2 comprises that also being used for the switch pressure fan connects 2402 on/off switch, and the replacement button that resets system when in a single day taking place to report to the police.Should be understood that, because system still is in the process of setting up desired pressure in the face shield, so system controls to avoid alarm to be triggered through time delay when starting.Except the excessive loss of avoiding medicine, using with the face shield of user coupling also provides at the extra protection that enters the air-polluting porch in the face shield along the face shield periphery (above the protection that is provided by the malleation in the face shield or above).

As discussed above, medical port comprises two parts: hose adapter and mixing chamber.Fig. 4 has shown a kind of embodiment of mixing chamber 4000, and itself and hose adapter 4050 are integrally formed.The chamber 4000 of this embodiment is provided with the sealing 4002 of example so that sealing is in conjunction with jar outer wall such as jar that shows or bottle (will go through below) better in Fig. 1.Chamber 4000 also comprises inner retainer or wall 4004, in case jar or bottle are pulled in the cell 4000, the front of jar or bottle is close on described retainer or wall.Therefore should be understood that in case jar or bottle firmly combine with retainer or wall 4004, then the inner air space 4020 that is limited by cell 4000 is exactly the space between wall 4004 and the electronic brake valve 4006.Therefore in operating process, the medicine of any evaporation or spraying will be filled in the inner space between wall 4004 and the valve 4006 and mix with wherein air.

In order to obtain greater flexibility, the embodiment of device of the present invention also comprise the bottle that is used to hold different size or jar adapter 5000.Particularly, adapter 5000 comprises the wideer input port that is used for big bottle or jar.Wideer input port comprises that three-way valve 5004 and any big bottle of restriction pass through the edge retainer 5006 of line 5002.Adapter also comprises the secondary narrower input port that is used for littler bottle and jar, and narrower opening has the sealing member 5014 that is used in conjunction with the outer surface of littler jar or bottle.In this case, edge retainer 5016 makes bottle or jar stop online 5010 places.Should be appreciated that when using adapter adapter rather than bottle or jar slide in the mixing chamber 4000.Therefore the inner air space is limited by space between wall 4004 and the valve 4006 (being illustrated by alphabetical A) and air space B and the C among Fig. 5 when big bottle is inserted in the adapter.When littler bottle or when jar being inserted in the adapter 5000, jar or flask be coupled among the C of space, stay regional A and B as the inner space so that allow medicine to mix with air.

Should be understood that other variant structures that are used for mixing chamber and adapter can be designed, and also do not deviate from spirit of the present invention.

Aerosol typically provides with the form of jar, and such as the albuterol jar, it typically combines with mixing chamber in mode discussed above.Make its nozzle strike pin in the chamber by inwardly pushing jar, such as on the pin 4020 or the pin of adapter, on pin 5020, drug dose jet or pill form is dispersed in the chamber.

The tablet of solid form can be arranged in mixing chamber or the adapter, and its a kind of embodiment shows in Fig. 6.In case the adapter of Fig. 6 comprises the depression 6000 that is used to hold tablet and tablet and is combined the end cap 6002 to cut out cell by hematocrit in cell the time with double seal 6004.The active evaporation component of hot plate 6010 forms is provided among this embodiment as shown in Figure 6.Plate 6010 can relate to electrical heating elements or realize with the chemical heat plate when two kinds of chemical substance generation exothermic reactions.In the embodiment that uses chemical substance, should be appreciated that the chemical substance that needs is left on outside mixing chamber to avoid any air pollution.The additive method that solid drugs is changed into gas form also falls in the scope of method of the present invention and drug conveying breathing equipment.As an example, by providing a kind of additive method that heat initiatively changes into gas form with solid for example in people's such as Rabinowitz U.S. Pat 7,070, it has described a kind of method that solid drugs is changed into gas 766 (incorporated herein by reference), such as: the medicine that alleviates migraine or pain, thereby medicine is coated in the stainless steel blade downside with reactant, paper tinsel is broken and it is heated to cause rapid phase transformation.Method of the present invention comprises that initiatively evaporation for example uses the energy such as visible, UV or IR light or use to have the ultrasonic surface of piezoquartz.

Fig. 7 has shown the adapter 7000 that has with heating cushion 7004 complementary undercuts 7002.End cap 7006 is once more in conjunction with double seal 7008.Should be understood that depression is used for holding it in heating cushion when liquid is evaporated.For liquid is administered in the cell, pipette or similar dispenser can be used.Should be appreciated that in order to carry the medicine of exact dose the amount of liquid that is imported in the cell must accurately be measured.In a preferred embodiment, for fear of overflowing, but the medicine bottle of the liquid of delivery of precise quantities be connected such as the adapter that in Fig. 5, shows with cell or adapter, described adapter has the adjusting device of medicine bottle nozzle.Conveying is accurate to one dosage and by guaranteeing that every a kind of described medicine bottle that all is used for avoiding waste in the medicine bottle is the dispersion bottle of describing in the U.S. Pat 6,386,394 (its content by reference and incorporated herein) people such as Vollrath.The medicine of exact dose is transported in the cell by filling bottle is simply pushed.As the another kind of form that liquid is carried, especially when conveying was carried out automatically by using Electronic Control mechanism, device of the present invention also can adopt inkjet technology.Though Fig. 6 and 7 has shown the adapter embodiment that is used to hold two kinds of different types of drugs, should be appreciated that the change adapter, also can in mixing chamber, carry out such as depression 6000,7002.

In addition, be used for liquid though described the embodiment of Fig. 7 above, but the another kind of the embodiment of Fig. 7 changes and also can be used for tobacco product or nicotine so that smoke at restricted area, perhaps allow gaseous medication (being cigarette or simple nicotine in this case) controlled, therefore can make the smoker give up the custom of smoking gradually.In a preferred embodiment, the chemical substance nicotine promotes wired or wireless button by user or directly joins in the air-flow with the form of high dilution in by the suction of determination of pressure sensor circulation or continuously.Inlet port 7010 can be suitable for holding medicated cigarette, is to be understood that length that mixing chamber must be enough is to holding medicated cigarette.And heating cushion is unwanted in such an embodiment.On the contrary, tobacco product or nicotine can be heated on concave surface 7002 and by heating cushion by hematocrit.When all these wherein possible harmful substances are sucked by user, can provide from the air outlet slit on the face shield and filter 2410 similar particulate filters.Up to now; the tobacco product that comprises harmful product such as tar is used to this device; preferred embodiment is included in the filter in the adapter shell, and it can be not only to protect user but also prevent that particle deposition is on the wall of face shield and be used for high-quality particulate filter on any air hose of device.

A kind of embodiment adopts the detachable disposable adapter that can buy in the place of drug vending, thereby has avoided the needs to the import that is used for adapter.Such embodiment can only provide single dose/adapter.

Though top embodiment has shown mixing chamber and the outward extending mixing chamber adapter of side direction, the present invention is not limited to this.A kind of embodiment uses vertically arranged mixing chamber adapter, as shown in figure 12.A kind of embodiment uses the mixing chamber adapter that enters that has up, as shown in figure 13.Should be appreciated that opposite mixing chamber itself can have import up, as shown in figure 14.This embodiment can make it under the help of gravity medicine is incorporated in the mixing chamber easilier.

Be suitable for holding bottle or jar also a kind of variant of adapter in Figure 10, show.Adapter 10000 has sealing member 10002 on the inner surface of its port of export 10003 with the outer surface of the mixing chamber 9002 that shows in conjunction with Fig. 9 in this embodiment.Though there is shown three sealing members, the sealing member of other numbers also may be utilized.Entrance point 10005 does not comprise when outer seal 10010 does not exist with convenient bottle or jar to be sealed with end cap 10012, and has inner seal 10014 so that the outer surface of combination bottle or jar.The adapter 10000 of this embodiment comprises end stops or wall 10004, its not only be used for bottle or jar be close to the surface, and in conjunction with the wall 9020 of mixing chamber.Therefore it should be understood that the inner air space is only limited by mixing chamber 9002 among this embodiment, rather than limit by adapter.

As discussed above like that, neither atomised form neither aerosol form the situation of liquid or solid medicine under, must carry out evaporation step.Evaporation can realize by energy is offered medicine, such as heating by medicine being carried out active.Different with heating, other form of energy also can be provided for medicine so that it is evaporated.For example, the use of physical vibration or ultrasonic agitation also can be obtained by the agitator that shows among Fig. 8.

On the contrary, medicine can be to have following characteristic, and promptly it evaporates for example passive evaporation easily in the situation that does not have external factor to get involved.

Above-mentioned discussion concentrates on aerosol that is suitable for carrying in air-flow or atomised form or with the form that requires to evaporate subsequently medicine is distributed in the mixing chamber as an alternative.The medicine that another importance relates to aerosol, atomizing or evaporation is incorporated in the air-flow.This relates to it is transported to from mixing chamber in the adapter shell 2450,3500,3502,4050 with controllable mode.

Any suitable method that medicine is moved to from mixing chamber in the air-flow of hose coupling all can be used.In one embodiment, evaporation, atomizing or the aerosol in the mixing chamber 8000 forms Venturi effect (Venturi) extraction by the swan-neck 8002 that shows among Fig. 8.Therefore air-flow also quickens to form low-pressure area with opening 8004 places at pipe in pipe 8002 bent around.This extracts medicine out chamber 8000.

The another kind of embodiment that uses Venturi effect that medicine is pulled out from the chamber or extracted out shows in Fig. 9.Here 9002 exit forms the baffle 9000 that has the water droplet wing shapes in this embodiment in the chamber.Inlet or passage are provided for medical port and take in to be used for air, so that fresh air enters mixing chamber.

As the Venturi that medicine is extracted out from mixing chamber substitute or additional, air-flow can be directed and be directed in the mixing chamber so that medicine is released.In fact, the embodiment that shows among Fig. 9 also comprises this progradation, as defined by the intake channel 9010 than the lower end of the deflector 9000 of low side.

Mixing chamber is pressurized in another embodiment, for example directs into the external source pressurization of the pipeline of mixing chamber by the high-pressure area from system.The method of this air pressure that increases in mixing chamber is used for promoting the dosing air and leaves mixing chamber when the switch valve between mixing chamber and the hose adapter is opened.

Though top embodiment depends on low pressure or air-flow and is transported to medicine outside the mixing chamber and enters hose adapter, another kind of embodiment uses the physics advance mechanism of piston 11000 forms as shown in Figure 11.Piston can by user manually promote or can with motor or spring mechanism coupling little by little piston inwardly being promoted, all the dosing air in mixing chamber are all discharged from mixing chamber.Helical spring 11002 and bar 11004 are provided in this embodiment, have been used for piston 11000 being pushed back and making spring be compressed.In case bar 11004 is released, the tensile force of spring 11002 is pushed to piston in the mixing chamber 11010, and the air that is filled with medicine is discharged in the hose adapter 11030 through electronic valve 11020.

Figure 12 and 13 has shown the different embodiment of adapter, and Figure 14 has shown the embodiment of mixing chamber, and they all are provided for the vertical installation of bottle to utilize gravity feed.

In order to control the discharge that enters into the air of hose adapter from mixing chamber, provide valve system, such as the valve among the electronic valve among Fig. 4 4006 and Figure 11 11020.Under the situation of using electronic brake valve 4006, use electronic valve known in the art.Under the situation of using valve 11020, use electromechanical shutters mechanism, for example those that in photographing unit, find.In order to control flowing of air process valve or shutter, opening or aperture can be controlled.As an alternative, with always keep opening or aperture open and to change the size of opening simply different, valve or shutter can close off and on and open so that small amount of drug is discharged in the air-flow.

Controlled way comprises the part medicine that each release user sucks in one embodiment.In one embodiment, controller is according to a series of suctions, the supervision of breathing out and discharging, and for example twice of the air-breathing or discharge air-breathing by three times after of per twice or three times is air-breathing when not having medicine to be disperseed monitors air-breathing and exhales and the release medicine.Pattern or series can change based on the character of medicine.In addition, based on the degree of depth of personal breathing how, air pressure or air-flow can be considered with size that changes its aperture that is opened or time length.And in one embodiment, some other devices that button, instant shut-in or be used to transmits controller signals are used with the indication user about medicine expectation dose such as next inhalation cycle when some following single administrations.In this mode, medicine can periodically preferably be carried by the patient, keeps the advantage of regularly carrying simultaneously.In another kind of embodiment, medicine can be provided in a continuous manner, rather than provides in the mode of pulse.

As discussed above like that, system can comprise pick off be used to indicate air flow to the speed of user, can show to calculate dosimetry parameter by the controller output of using.Flowing velocity can be measured by many kinds of methods in this application.It can or contact a large amount of air flow sensor that are provided with the air-flow in the hole of flowing through by heated filament blast gauge, chemical blast gauge and directly measure.Preferably, but the sensing working pressure pick off that flows carry out indirectly.These pick offs can with pitot tube, perhaps the pick off of some numbers (for example three) is used in combination, these pick offs are provided with the air-flow inlet port on every side of the Venturi tube structure of inside, hole.Based on the pressure by sensor determination, controller can be monitored the pressure differential of passing Venturi tube structure then and be carried out calculated flow rate based on this information.The use of a plurality of pick offs can allow controller that data are averaged, and owing to disturb to wait the transient error reading from single-sensor can be left in the basket so that produce accurate data set, the function of medical port is controlled based on this data set.In addition, if comprise a pressure transducer at least to measure atmospheric pressure, then controller can also be monitored the pressure in medical port, flexible pipe and the face shield and whether be formed negative pressure so that determine wearer's breathing, comes the insufficient situation of Display Drum fan unit workload.In one embodiment, can comprise the algorithm that is used to control shutter or valve, so that discharge medicine with controllable mode by the controller that is controlled to be aerator and provides power to control air velocity or pressure.

Pressure transducer or flow sensor can be installed in the adapter shell, and it is all sealed to be used for line is passed any hole of the adapter shell of shell or pipe.This can realize by the adapter seal shell.In one embodiment, all the sensors in the adapter shell and monitor all are installed in by intermediate plate and are fastened on the printed circuit board (PCB) on the inner surface of shell.Be exposed in the air-flow for fear of electronic component, above having the circuit board of its element, scribble protective finish.Though controller also can be installed on the circuit board, in another kind of embodiment on pick off and monitor and the external circuit board or the monitor in the blower drum be connected.Be administered among the embodiment of pulmonary at insulin, device of the present invention provides the feedback circuit from the insulin monitor to controller so that monitor based on the blood/sugar level the user blood, thereby calculates required insulin administration amount automatically.

In controller is installed in embodiment on the circuit board, can eliminate together by independent current source is provided on circuit board at the electric wire in the medical port outside, for example pass through watch cell.

The medical treatment port power supply also can by the energy such as can not or inconvenience enter the solaode that uses in the field of electron grid, little wind turbine or fuel cell provides.

For the accurate amount of the medicine that guarantees to be transported to user, importantly be that control is introduced in the amount of medicine in the mixing chamber or chemical substance and leaves the air velocity of medical port (entering in the air-flow).If these values are all known, then mixing velocity and transporting velocity can be determined and control.System can allow this mixture to carve when appropriate and take out from mixing chamber with suitable time quantum in mixing chamber the drug conveying of fixed amount then, and perhaps it can conduct drugs in the mixing chamber by continuous process.

In case the medicine in the mixing chamber is transported in the air-flow, it is carried to face shield by flexible pipe 2424 (Fig. 2) or flexible pipe 11050 (Figure 11), such as the face shield among Fig. 2 2422.

Flexible pipe comprises liner in an embodiment, and flexible pipe is by polymer filtration material of (this is contingent, especially the medicine of some types) in air-flow not being made.In addition, in an embodiment flexible pipe by preventing or reducing that this material is made or be lined with to the material of chemical degradation owing to be exposed in the medicine.In a kind of embodiment also, flexible pipe removably is connected to allow it to be replaced every now and then.The degradation material and the medicine residue that accumulate on this permission flexible pipe inner surface are processed.

Though use shutter or electronic control valve between mixing chamber and the adapter shell among the embodiment discussed above, another kind of embodiment provides shutter and the valve that is installed in the mixing chamber.Such embodiment shows that in Figure 15 it comprises the mixing chamber 16000 by printed circuit board (PCB) (PCB) 16002 separated into two parts 16010,16012.PCB16002 provides two air flow paths: one between top 16010 and bottom 16012 by shutter or valve 16004, one is used for through passage 16022 for 16010 air-flow provides passage to top from adapter shell 16020.Back one air flow path comprises hole or space 16024 simply in printed circuit board (PCB) (PCB) 16002.As an alternative, the control import 16024 of mixing chamber rather than the outlet of mixing chamber are sentenced in valve 16004 hole that enters that can be positioned in from the lower case to the upper case.Bottle or jar 16030 are placed in the vertically extending support 16032.In one embodiment, vertically extending support 16032 can be littler structure, and for example the child uses face shield, make bigger-for example the adult 16030 can not be engaged in the littler support 16030 with jar.By this way, avoid child or littler patient's overdose.

Under the situation of using jar, pin 16034 closely contacts on nozzle to allow the medicine piece to be discharged in the top 16010.Under the situation with liquid dispersing liquid from bottle or other liquid distributors, heating cushion or piezoelectric board 13036 evaporate liquid.No matter when valve 16004 is opened, and the air pressure in the top 16010 that is formed by the air that enters through via hole 16024 forces air admission bottom 16012.

Medicine is by being drawn in the passage 16040 of adapter shell 16020 to the Venturi effect that the curved surfaces 16042,16044 of adapter shell 16020 forms by import.In this embodiment, adapter shell 16020 is divided into medicine delivery passage 16040 and no medicine gas channel 16048 is walked around venturi zone 16042,16044 and the dosing air do not imposed on user with the permission air.

Among a kind of embodiment shown in Figure 16, adapter shell 16020 is bifurcated not, and only comprises a passage 16040.Therefore, they mix when the air of dosing air and not dosing is walked around venturi zone 16042,16044.

The adapter shell of bifurcated illustrates with further reference to the embodiment shown in Figure 17 and 18.Figure 17 and 18 has shown the bifurcated passage 16040,16048 that extends to face shield 17000,18000.Using under the situation of face shield 17000, medicine delivery passage 16040 extends to tube head 17010, and described in this embodiment tube head is fixedlyed connected with face shield to avoid because of swallowing of neglecting or to block harm.In other embodiments, tube head or sleeve pipe removably connect to allow it to be dropped and to replace to new tube head or sleeve pipe after use is a certain amount of.The adding of tube head guaranteed that all dosing air arrive the oral cavity of user, guaranteed still less drug waste and accurate dose more.Should be appreciated that this embodiment is suitable for the application that its Chinese medicine preferably sucks through the oral cavity.In the embodiment of Figure 18, passage 16040 extends to the nose mouth of sleeve pipe 18010 forms.Sleeve pipe can be designed to be engaged in the single nostril and use, and allows user Alternating Transportation between two nostrils, and perhaps carry simultaneously in two nostrils.This embodiment is preferred for the medicine that sucks through nose, and provides ratio simply to fill face shield more accurate dose and better conveying once more.In going back an embodiment (wherein being), in mouth 17010 and sleeve pipe 18010 do not need to be included in by nose or inessential by the oral cavity suction.Opposite medicine is transported to face shield simply.Preferably, face shield cooperates with the face of user well, makes medicine minimize through the drug loss that is caused by the space between user and the face shield periphery.In order to eliminate the waste product that is produced by medicine, end cap 16050 is installed on the medical port so that the inside of approaching medical port becomes easier.

As discussed above like that, medicament distribution is in mixing chamber or be transported to can be by the control of the controller on the circuit board in the medical port or by the controller control that is installed in the blower drum in the air-flow.In an embodiment, medicament reservoir have with predefined parameter according to being connected and can be programmed, the memory stick of pre-programmed (memory stick) in factory for example perhaps makes up a prescription with the type, user age or the dosage that are suitable for certain drug, drug level, dispersal device and other relevant parameters to make up a prescription according to specific use by the pharmacy.Programming can by use wireless connections for example bluetooth Zigbee (purple honeybee) wait and realize.Should be understood that controller also can be collected different pressures, flow velocity, suction volume of air of real time data such as a period of time etc.Controller can utilize these data to regulate the drug conveying of medical port to keep ideal dosage level.Can be undertaken by wired or wireless mode to the communication of medical port from being installed in blower drum.

In addition, as shown in figure 19, controller in medical treatment port or the aerator can obtain input data (wired or wireless) from blood pressure, heart rate, blood oxygen saturation or blood glucose sensor 19001 etc., to start or stop drug dose based on pre-defined algorithm or to change dosage level or frequency.Medical treatment port one 9003 itself can be through wired or by wireless transmitter 19002 data are offered near the medical port other devices.In this mode, data include but not limited to blood pressure, blood oxygen saturation level, heart rate, blood sugar level, frequency of respiration, respiratory volume etc., can be monitored in real time, such as with these devices and the local computer monitor 19004 of medical port one 9003 communications 19005 on monitor.Except with pick off and medical port communication, local monitor 19004 can be connected with network by wired or wireless, such as being connected with local area network or wireless router 19006.In a similar fashion, pick off can be connected with the same local area network or the router of this diji by wired or wireless mode with medical port, and making all data all is available for this diji and network.By this way can the remote monitoring patient's states for the health care personnel and regulate dosage that medical port changes to the required air-flow of patient, frequency of delivery, temperature, humidity etc. from remote location and simultaneously the patient is monitored in real time such as nurse or doctor.Should be appreciated that for this embodiment patient need in the armarium of hospital, could not realize but have can be in the domestic nursing facility performance of operational excellence.As discussed above like that the wireless connections scheme can make in bluetooth, Zigbee (purple honeybee) or 802.11 standards, and wired connection can be serial (serial), such as I ²C or simple R S232.

In the embodiment that Figure 20 shows, medical port 20001 can be engaged in a plurality of can be simultaneously or with different frequency such as different or alternately in the inhalation cycle process a plurality of ampoules 20002 of the multiple medicine of weight feed cooperate.Ampoule is installed in the position that enters the top that also can be directed to medical port on the slide mechanism 20003 in this embodiment, allows controller to control which kind of medicine and is disperseed.But the system of Figure 20 needn't be as the unique embodiment that is used for the multiple medicine of weight feed.For example, the medical port of Figure 16 can be designed to diametrically opposite two or more mixing chamber simply, allows the dosage of medicine to flow into the single air-flow from a plurality of mixing chambers.

In addition, because in a preferred embodiment, device can be measured the degree of depth and the volume of each inhalation cycle, and drug conveying only can be triggered in the inhalation cycle of high power capacity and it is best for drug conveying.This can be by the recent history of METHOD FOR CONTINUOUS DETERMINATION for the inhalation cycle of specific user in the time period of a few minutes, then relatively the slope of curve for inhalation and the degree of depth (before arriving the deep level of circulation) in case the drug release that triggers in the breathing process realize.Repeatedly the unexpected decline that can be used to confirm some situations such as heartbeat output is measured in input, and the unexpected decline of described cardiac output triggers to increase among certain drug and/or described Anywhere in this application another embodiment and sucks airborne oxygen level.

Though top embodiment uses flexible pipe to conduct drugs to face shield, the present invention is not so limited.In one embodiment, for example, medical port directly is connected between face shield and the blower drum and does not use flexible pipe.Typically, the medical port of this structure can limit adapter shell so that receive outlet from mixing chamber, and is connected between face shield and the blower drum.

In case medicine arrives face shield, user sucks medicine simply.By being provided at the ability of only carrying small amount of drug in a period of time, the absorption of medicine obtains increasing.As discussed above such, face shield is preferably the face shield of the person of being used face so that minimize along the effusion of face shield ambient air.A kind of embodiment uses face and the nasal area air feed of amalgamation collector as user.In a kind of described embodiment, air that the mode that slide block is included to physics changes to nose and ratio to the air of face.In another kind of embodiment, different with the face shield that covers face and nose, the local face shield that only is used for nose or only is used for face can be used.

Can expect,, prevent that the protective measure of incorrect medicament or incorrect medicament dosage can be bonded in this system for some medicines.These medicines and user recognition system can relate to the simple color coding of medicament reservoir or the contraction of geometry, and the medicine of the dosage that prevents to be grown up is given the child by the mask system that is suitable for the child by administration.More complicated system can with drug regimen combine can be by the container of the microprocessor inspection in the mask system with the bar code of confirming correct medicine and correct dose or RFID (RF identification) labelling in.In this system, prescription can be downloaded in the face shield microprocessor, perhaps can or pass through another kind of RFID labelling by RF scheme such as bluetooth or Zigbee (purple honeybee).The people's who uses face shield mask system informed medicine and dosage by described prescription.The Advanced Edition of system even can be by they the RF labelling itself or the identity of the face shield user that confirms password.Similarly, the data of face shield use comprise that user, time and use date and system mode are to determine correct drug conveying.This especially the recipient of medicine because Memorability, attention difference need monitoredly, perhaps carry out because treatment relates under the situation of substance addiction.

It is also contemplated that and to wish to prevent that more a spot of medicines from arriving room air and preventing that other habitants that do not need medicine from sucking the air of discharging by from medication person pulmonary.For example, if use mask system to suck the nicotine of low dosage with the individual, this just needs this possible addictive substance not sucked by other indoor members, even if suck with very low dosage.This can filter the airborne small particle that is present in the face shield by filter and realize, perhaps even in some cases makes the pharmaceutical chemistry inactivation by material such as active carbon.In addition, should be known that in a preferred embodiment that above mentioned particulate filter can be the sterile chamber of being made by certain material, make inner surface be covered with the high reflectance in the 280nm wave-length coverage at about 250nm.The sterile chamber utilize by mercury vapour lamp, light emitting diode or other light emission electrooptical devices (all described devices are emitted in the UV radiation between about 250nm and the 280nm) but the ultraviolet light that produces with the RNA or the DNA of the pathogen of destroying any air-borne transmission of breathing out by user.

For the comfortableness that increases, the face shield of high flexibility can be designed, it has more inflexible part to limit the air space of user face and nose front in central authorities, and perhaps becoming gradually towards face and nasal area more has rigidity, and along around become flexible.Face shield also comprises a plurality of sealing members that extend in parallel along the face shield periphery, so that the better sealing to the user face to be provided.In highly harsh application, wherein any pollutant from the outside should be avoided and be relied on malleation in the face shield and a plurality of sealing member also enough not to guarantee under the situation of safety, the excision of suggestion by making face shield more difficult and even the adhesive agent that can require solvent just can extract face shield is connected with the user face.

In addition, in order to increase the adaptability to pediatric patients, some embodiment can adopt molded and face shield that be decorated cartoon or animal character, can make entertainment for children and increase their the emotion comfort level to device.Similarly, face shield can be made into more to attract the shades of colour of child and adult's user.In a similar fashion, the mike of use employing Sound Processor Unit and the communication system of speaker system can be increased and be beneficial to carry out communication by face shield, perhaps increase availability to child or adult (sound tuner, simulation cartoon or TV personage, for example Darth Vader once more by adding funny feature ^TM, Spongebob Squarepants ^TMDeng).

Though adopting by reference in the above is used for the induction system of the face shield of drug conveying and purifying gas flow system and method for the present invention is described, but it will be appreciated by those skilled in the art that method and system of the present invention also can be used to the treatment of intubated patient.Above-described device and system can be by ventilation fan (venitlator) and/or the respirator of repacking to be used to be applicable to intubated patient under suitable situation, as can be by understood by one of ordinary skill in the art.

Disclosed by the inventionly be provided for the patient at this and in a period of time, purify air and the mode of safe administration by suction in the mode of accurate control dosage.Though some embodiment have been discussed above, should be understood that the present invention is not limited to these embodiment, but also can realize by other modes that do not depart from scope of the present invention.

Claims (14)

1, a kind of with the method for drug administration to patient's respiratory system, comprising:

Use to give patient as the air of malleation with drug conveying with respect to atmospheric pressure, wherein, the patient can not have assisted respiartion.

2, method as claimed in claim 1 is characterized in that, described air is for purifying air.

3, method as claimed in claim 1 is characterized in that, described air is with the pressure feed of 1cm water column to the 30cm water column.

4, method as claimed in claim 1 is characterized in that, described medicine is transported to the patient through face shield, and wherein, face shield is sealed in around patient's the nose and face fully.

5, method as claimed in claim 1 is characterized in that, medicine is a pulmonary drug.

6, method as claimed in claim 1 is characterized in that, medicine is a systemic medication.

7, method as claimed in claim 1 is characterized in that, medicine is selected from selects down group, comprising: albuterol, salbutamol sulfate, atropine sulfate, beclometasone, dipropionate, methanesulfonic acid is than Tuo Teluo, budesonide, formoterol fumarate, sodium cromoglicate, desflurane, dexamethasone sodium phosphate sodium phosphate, Dornase Alfa, enflurane, epinephrine, gynergen, flunisolide, fluticasone, formoterol fumarate, halothane, iloprost, insulin, ipratropium bromide, hydrochloric acid dilabron, isoflurane, the hydrochloric acid isoprenaline, albuterol hydrochloride, metaproterenol sulfate, methacholine chloride, furancarboxylic acid Mo Meitasong, nedocromil that, nicotine, nitric oxide, pentylenetetrazol isethionate, calcium trisodium pentetate, pentetic acid zinc trisodium, pirbuterol acetate, virazole, the new naphthalene Fitow of salmaterol, sevoflurane, tetrahydrocannabinol, tiotropium bromide, tobramycin, triamcinolone acetonide, zanamivir, and their compositions.

8, method as claimed in claim 1 is characterized in that, medicine is selected from down group, comprise: 13-cis-retinoic acid, 2-penicillin F, L-α-acetylmethadol, S-13-cis-retinoic acid, 2-penicillin F, L-α-acetylmethadol, S-adenosylmethionine, acebutolol, aceclofenac, acetaminophen, acephenazine acetophenazine, acephenazine acetophenazine, ademetionine, adinazolam, adrafinil, albuterol, albuterol, salbutamol sulfate, alfentanil, Fentanyl, alizapride, allylprodine, Alminoprofen, Almogran, alpiropride, alphaprodine, alpidem, alseroxylon, diamantane (obsolete), An Beishengtan, amesergide, amfenac 4-[2-(dimethylamino)propionamido, Amiodarone Hydrochloride, amisulpride, amitriptyline, amixetrine, amlodipine, amoxapine, amoxicillin, Amperozide, amphenidone, amphetamine, ampicillin, amyl penicillin, ropinirole, anileridine, azapropazone, apomorphine, diacetic acid Ah bundle morphine, atenolol, atropine sulfate, azacyclonol, azasetron, azatadine, the azidocillin, bacillus calmette-guerin vaccine, baclofen, propanoic acid times chlorine rice, benzene is quiet, 1-(benzoyl)-2-(.alpha.-methylbenzyl)hydrazine benoxaprofen, benperidol, benserazide, benzpiperilone, benzquinamide, benzetropine, benzydamine hydrochloride, benzfetamine, benzylpcnicillin, bezitramide, binedaline, biperiden, bitolterol, methanesulfonic acid be than Tuo Teluo, brofaromine, bromfenac sodium, bromine isoamyl vinegar, bromocriptine, bromopride, bromperidol, brompheniramine, brucine, buclizine, budesonide, budesonide, formoterol fumarate, 1-tert-butyl-4,4-diphenylpiperidine., bufexamac, buprenorphine, the butyl propanoic acid, buramate, buspirone, butaclamol, butaperazine, Bu Tuonuo coffee, butriptyline, cabergoline, caffeine, N-phosphoamide aspartic acid calcium, tetrahydrocannabinol, captodiame, capuride, Dicentrine, carbcloral, Carbenicillin, carbidopa sheet, carbifene, carbromal, carfecillin, carindacillin sodium, caroxazone, carfenazine, carpipramine, carprofen, cefazolin sodium, Cefmetazon (Sankyo), cefmetazole, cefoxitin, cephazolin II, cephalexin, cefaloglycin, cafalotin I, cephalosporin, cephalosporin, cefalotin, the methoxy cephalosporin A, methoxy cephalosporin B, cephamycin C, the methoxy cephalosporin, cefradine, Cericlnmine, cetirizine, cloral betaine, chlordiazepoxide, chlorobutinpenicillin, chlorphenamine, chlorpromazine, chlorprothixene, choline, sharp scholar, cilazapril, cilostazol, cinchophen, cinmetacin, cinnarizine, ciramadol, citalopram, clebopride, clemastine, clobenzepam, clocapramine, clomacran, clometacin, clometocillin, clomipramine, clonidine, Clonitazene, clonixin, Chlorthixol Decanoate, clopriac, 8-, clotiapine, Clovoxamine, chlorine spills XiLin, clozapine, codeine, cotinine, sodium cromoglicate, cyamemazine, cyclacillin, cyclizine, cyclobenzaprine, cyclosporin A, Cyproheptadine, deprenyl, desflurane, desipramine, dexamethasone sodium phosphate, Isomeride, dexmedetomidine, dexamphetamine, dextromoramide, Propoxyphene, heroin, stable, diclofenac, diclofenac, dichloro spills XiLin, paracodin, dihydro Ergokryptine, dihydroergotamine, diltiazem, diphenhydramine, diphenicillin, diphenidol, diphenoxylate, dipipanone, disulfiram, dolasetronmethanesulfonate, domperidone, Dornase Alfa, dosulepin, doxepin, amycin, doxylamine, dronabinol, droperidol, droprenilamin HCl, duloxetine, eletriptan, eliprodil, Enalapril, enciprazine, enflurane, entacapone, An Taole, ephedrine, epinephrine, eptastigmine, ergolinepramipexole, Ergotamine, gynergen, etamiphyllin, etaqualone, ethambutol, ethoheptazine, etodolac, famotidine, Fenfluramine, sweet smell is the slave too, fexofenadine, fentanyl, the fluorine gram is given birth to, fluconazol, flunisolide, fluoxetine, flupenthixol, fluphenazine, flupirtine, flurazepam, fluspirilene, fluticasone, fluvoxamine maleate, formoterol fumarate, frovatriptan, gabapentin, galantamine, gepirone, motilin, glutathion, granisetron, haloperidol, halothane, helium-oxygen gas mixture, penicillin, hetacillin, hydromorphone, hydroxyzine, scopolamine, ibuprofen, idazoxan, iloprost, imipramine, indoprofen, insulin (recombinant human insulin), ipratropium bromide, iproniazid, ipsapirone, isocarboxazid, the hydrochloric acid dilabron, isoflurane, isometheptene, isoniazid, rifampicin, pyrazinamide, ethambutol, isoproterenol, hydrochloric acid isoprenaline, isoproterenol, sorbide nitrate, ketamine, ketoprofen, ketorolac, ketotifen, ketanserin, lazabemide, leptin, lesopitron, albuterol hydrochloride, levodopa, levorphanol, lignocaine, lisinopril, lisuride, lofentanil, lofepramine, lomustine, loprazolam, loratadine, L0, lorazepam, loxapine, maprotiline, mazindol, mazipredone, meclofenamic acid, mecloqualone, medetomidine, the medifoxamine, buronil, DMAA, menthol, pethidine, spasmedal, meptazinol, mesoridazine, methylene ampicillin, hydroxyphenyl isopropylamino ethanol, metaproterenol sulfate, methacholine chloride, methadone, methaqualone, methicillin, methyprylon, mesuximide, methylphenidate, methyprylon, desernil, metoclopramide, methophenazine, metomidate, metopimazine, metopon, metoprolol, metralindole, mianserin, midazolam, midalcipran, minaprine, mirtazapine, moclobemide, mofegiline, molindrone, furancarboxylic acid Mo Meitasong, morphine, nabilone, benzene first butazone, nafthicillin, nalbuphine, nalmefene, nalorphine, naloxone, Naltrexone, naratriptan, nedocromil is received, nefazodone, nefopam, nicergoline, nicotine, nicotine, nifedipine, nisoxetine, nitrous oxide, nitroglycerine, NOMI, nortriptyline, fat inhibin, olanzapine, omoconazole, ondansetron, brocasipal, oxprenolol, the Ou Kexike ingot, palonosetron, papaveretum, papaverine, paroxetine, pemoline, penfluridol, penicillin N, penicillin, Penicillin S, penicillin V, pentylenetetrazol isethionate, pentazocine, pentaacetic acid, calcium trisodium pentetate, pentetic acid zinc trisodium, pentobarbital, peptide, pergolike, Pericyazine, perphenazine, pethidine, benzene azoles star, phenelzine, phenobarbital, Phentermine, fragrant appropriate amine, phenylhydrazine, phosphodiesterase-5, pilocarpine, pimozide, pipamperone, the acetyl piperazine, the general piperazine of piperazine, pirbuterol acetate, piroxicam, pirprofen, pizotifen, pizotifen, polypeptide, polypeptide YY, pramipexole, prentoxapylline, procaine, procaterol, Procaterol Hydrochloride, prochlorperazine, procyclidine, promazine, phenergan, propacetamol, propanolol, propentofylline, Propofolum, the third oxygen sweet smell, propranolol, protein, protriptyline, Quetiapine, quinine, rasagiline, reboxetine, remacemide, remifentaniliva, remoxipride, retinal, virazole, Rimonabant, Risperidone, ritanserin, ritodrine, rizatriptan, Roxindole, Salicylate, the new naphthalene Fitow of salmaterol, salmaterol, scopolamine, selegiline, Sertindole, Sertraline, sevoflurane, sibutramine, 'Xiduofeng ', spheramine, spiroperidol, sufentanil, dogmatil, sumatriptan, tandospirone, terbutaline, terguride, testosterone, testis acetic acid element, testosterone enanthatas, androlin, tetrahydrocannabinol, thioridazine, tiotixene, Tiagabine, tianeptine, timolol, tiotropium bromide, tizanidine, tobramycin, tofenacin, tolcapone, tolfenamate, tolfenamic acid, topiramate, tramadol, tranylcypromine, trazodone, triamcinolone, triethylperazine, trifluoro pyridazine, trifluperidol, triflupromazine, benzhexol, temaril, trimethobenzamide, trimeprimine, Novaban, tryptophan, valproic acid, Vardenafil, venlafaxine, verapamil, vigabatrin, Viloxazine, Yohimbine, zafirlukast, zalospirone, zanamivir, zileuton, Ziprasidone, Zomitriptan, Bikalm, zopiclone, Zotepine, Ciatyl, and their compositions.

9, a kind of the device of drug administration to patient's respiratory system be is characterized in that, device uses with respect to atmospheric pressure as the air of the supply of malleation with drug conveying to the patient, wherein, the patient can not have assisted respiartion.

10, device as claimed in claim 9 comprises the face shield that is used to conduct drugs to the patient, it is characterized in that, face shield is sealed in around patient's the nose and face fully.

11, device as claimed in claim 9 is characterized in that, air provides with the pressure of 1cm water column to about 30cm water column.

12, device as claimed in claim 9 is characterized in that, air is for purifying air.

13, a kind of with the method for drug administration to patient's respiratory system, comprising: use to give patient as the gas supplied of malleation with drug conveying with respect to atmospheric pressure, wherein, the patient can not have assisted respiartion.

14, a kind of the device of drug administration to patient's respiratory system be is characterized in that, device uses with respect to atmospheric pressure as the gas supplied of malleation with drug conveying to the patient, wherein, the patient can not have assisted respiartion.

Images