CN101548972B - Solid pharmaceutical composition containing repaglinide - Google Patents
Solid pharmaceutical composition containing repaglinide Download PDFInfo
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- CN101548972B CN101548972B CN 200810103326 CN200810103326A CN101548972B CN 101548972 B CN101548972 B CN 101548972B CN 200810103326 CN200810103326 CN 200810103326 CN 200810103326 A CN200810103326 A CN 200810103326A CN 101548972 B CN101548972 B CN 101548972B
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- repaglinide
- pharmaceutical composition
- solid pharmaceutical
- composition containing
- solid composite
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Abstract
The invention discloses a solid pharmaceutical composition containing repaglinide. The solid pharmaceutical composition can exist in various forms of dispersing tablets, oral disintegrating tablets and capsules and is used for curing the type 2 diabetes of which the high blood sugar cannot be effectively controlled by diet control and exercise.
Description
Technical field
The present invention relates to a kind of solid composite medicament that contains repaglinide, especially a kind ofly be used to treat the repaglinide solid composite medicament that diet control and motion exercise can not effectively be controlled the type 2 diabetes mellitus of hyperglycemia.
Background technology
Repaglinide is a kind of non-sulfonylurea Drugs Promoting Insulin Secretion; 36KDA protein-specific on the potassium-channel of the outer dependency ATP of these article and islet cells film combines, and potassium channel is closed, the calcium channel opening; Flow of calcium ions; Promote insulin secretion, it acts on faster than sulfonylurea, so hypoglycemic activity is very fast after the meal.These article are mainly used in the patient that diet control and motion exercise can not effectively be controlled the type 2 diabetes mellitus of hyperglycemia.
WO0121159 discloses the combination medicine of the medicine of a kind of repaglinide or Nateglinide and other treatment diabetes, is used to prevent and treats type 2 diabetes mellitus reach disease or the illness relevant with diabetes.This patent has also been protected the composition and method of making the same of Nateglinide and pharmaceutically acceptable carrier.But the pharmaceutical composition of its protection can only stripping in 30 minutes, and onset is slower.
The invention provides a kind of repaglinide solid composite medicament that can quick acting, can stripping onset within 15 minutes, and be oral cavity disintegration tablet or dispersible tablet, patient's taking convenience.
Summary of the invention
The applicant provides a kind of repaglinide folk prescription oral solid formulation, and is rapid-action, and patient's compliance is high.
The invention provides a kind of solid composite medicament that contains repaglinide, contain percentage by weight and be 0.1%～10% repaglinide and 80%～99.9% pharmaceutically acceptable auxiliaries.
This solid composite medicament provided by the invention, existence form can be oral cavity disintegration tablet, dispersible tablet.
This solid composite medicament provided by the invention, pharmaceutically acceptable auxiliaries are one or more the mixture in filler, disintegrating agent, binding agent, correctives, the lubricant.
This solid composite medicament provided by the invention, filler are one or more the mixture in lactose, microcrystalline Cellulose, starch, pre-paying starch, mannitol, the calcium hydrogen phosphate.
This solid composite medicament provided by the invention, disintegrating agent are one or more the mixture in polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, swollen speed, the low-substituted hydroxypropyl cellulose sodium.
This solid composite medicament provided by the invention, binding agent are one or more the mixture in water, polyvidone, starch, ethanol, the sodium carboxymethyl cellulose.
This solid composite medicament provided by the invention, correctives are one or more the mixture in sucralose, citric acid, green apple essence, the acrylic resin.
This solid composite medicament provided by the invention, lubricant are a kind of in magnesium stearate, the Pulvis Talci.
This solid composite medicament provided by the invention is mainly used in the type 2 diabetes mellitus that treatment diet control and motion exercise can not effectively be controlled hyperglycemia.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description, but be not limited to following embodiment.Wherein " % " is meant " weight % ".
Embodiment 1: its existence form is an oral cavity disintegration tablet
Preparation technology: take by weighing repaglinide, microcrystalline Cellulose, sorbitol and low-substituted hydroxypropyl methylcellulose sodium by recipe quantity, mix homogeneously, adopting diameter is the scrobicula stamping of 12mm; Pulverize, cross 30 mesh sieve granulate, add flavoring orange essence and magnesium stearate; Mixing, tabletting.
Embodiment 2: its existence form is a dispersible tablet
Preparation technology: take by weighing repaglinide by recipe quantity, take by weighing all the other adjuvants except that green apple powdered flavor, magnesium stearate of recipe quantity, cross 80 orders, mixing adds 50% alcohol-water solution and makes binding agent, and the system soft material is crossed 20 mesh sieves and granulated drying, 24 mesh sieve granulate; The magnesium stearate, the green apple essence that add the prescription ratio, mixing, tabletting.
Embodiment 1 sees the following form with the sample dissolution that embodiment 2 makes:
Embodiment 1 and embodiment 2 sample stripping kilsyth basalts
| 5min | 10min | 15min | 30min | |
| Embodiment 1 | 92％ | 95％ | 100％ | 99％ |
| Embodiment 2 | 93％ | 96％ | 99％ | 99％ |
Claims (1)
1. an oral cavity disintegration tablet pharmaceutical composition that contains repaglinide is characterized in that containing following components in weight percentage
Its preparation method is following: take by weighing repaglinide, microcrystalline Cellulose, sorbitol and low-substituted hydroxypropyl methylcellulose sodium, and mix homogeneously, adopting diameter is the scrobicula stamping of 12mm, pulverizes, and crosses 30 mesh sieve granulate, adds flavoring orange essence and magnesium stearate, mixing, tabletting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810103326 CN101548972B (en) | 2008-04-03 | 2008-04-03 | Solid pharmaceutical composition containing repaglinide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810103326 CN101548972B (en) | 2008-04-03 | 2008-04-03 | Solid pharmaceutical composition containing repaglinide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101548972A CN101548972A (en) | 2009-10-07 |
| CN101548972B true CN101548972B (en) | 2012-10-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810103326 Active CN101548972B (en) | 2008-04-03 | 2008-04-03 | Solid pharmaceutical composition containing repaglinide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101548972B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283813B (en) * | 2011-07-28 | 2017-05-24 | 万全万特制药江苏有限公司 | Medicinal composition containing repaglinide and preparation method thereof |
| CN102357085A (en) * | 2011-10-27 | 2012-02-22 | 苏州中化药品工业有限公司 | Stable method for preparing repaglinide compressed tablets |
| CN103040772B (en) * | 2012-06-20 | 2015-05-20 | 江苏豪森药业股份有限公司 | Repaglinide dispersible tablet and preparation method thereof |
| CN102743354A (en) * | 2012-07-31 | 2012-10-24 | 南京正科制药有限公司 | Repaglinide tablet and preparation method thereof |
| CN104644446B (en) * | 2013-11-25 | 2018-02-09 | 北京万生药业有限责任公司 | A kind of preparation method of Repaglinide pharmaceutical preparation |
| CN103690498A (en) * | 2013-12-18 | 2014-04-02 | 北京华禧联合科技发展有限公司 | Preparation method capable of improving stability of repaglinide tablets |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413107A (en) * | 1999-12-23 | 2003-04-23 | 诺瓦提斯公司 | Use of hypoglycemic agent for treating impaired clucose metabolism |
| CN1814300A (en) * | 2005-12-01 | 2006-08-09 | 广州中一药业有限公司 | Glinide drug adjuvant composition and method for preparing drug containing same |
| CN101137368A (en) * | 2005-03-08 | 2008-03-05 | 尼科梅德有限责任公司 | Roflumilast for the treatment of diabetes mellitus |
-
2008
- 2008-04-03 CN CN 200810103326 patent/CN101548972B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413107A (en) * | 1999-12-23 | 2003-04-23 | 诺瓦提斯公司 | Use of hypoglycemic agent for treating impaired clucose metabolism |
| CN101137368A (en) * | 2005-03-08 | 2008-03-05 | 尼科梅德有限责任公司 | Roflumilast for the treatment of diabetes mellitus |
| CN1814300A (en) * | 2005-12-01 | 2006-08-09 | 广州中一药业有限公司 | Glinide drug adjuvant composition and method for preparing drug containing same |
Non-Patent Citations (1)
| Title |
|---|
| 张理星等.那格列奈微粉化片的研究.《山东医药工业》.2003,第22卷(第3期),第6-7页. * |
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| Publication number | Publication date |
|---|---|
| CN101548972A (en) | 2009-10-07 |
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| ASS | Succession or assignment of patent right |
Owner name: AVENTIS PHARMA (HAINAN) CO., LTD. Free format text: FORMER OWNER: DEZHONG WANQUAN PHARMACEUTICALS TECH. DEV. CO., LTD., BEIJING Effective date: 20110816 |
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Free format text: CORRECT: ADDRESS; FROM: 100097 HAIDIAN, BEIJING TO: 570314 HAIKOU, HAINAN PROVINCE |
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Effective date of registration: 20110816 Address after: 570314 Nanhai Avenue, Hainan, Haikou, China, No. 279 Applicant after: Beijing D-Venturepharm Technology Development Co., Ltd. Address before: 100097 Beijing city Haidian District Sijiqing Wanquan Zhuang 3 Building Applicant before: Dezhong Wanquan Pharmaceuticals Tech. Dev. Co., Ltd., Beijing |
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| C14 | Grant of patent or utility model | ||
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Inventor after: Wang Shifeng Inventor after: Meng Fanjing Inventor before: Meng Fanjing |
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Free format text: CORRECT: INVENTOR; FROM: MENG FANJING TO: WANG SHIFENG MENG FANJING |