CN101544572B - 一种氨溴索衍生物及其制备方法 - Google Patents
一种氨溴索衍生物及其制备方法 Download PDFInfo
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- CN101544572B CN101544572B CN2008100841459A CN200810084145A CN101544572B CN 101544572 B CN101544572 B CN 101544572B CN 2008100841459 A CN2008100841459 A CN 2008100841459A CN 200810084145 A CN200810084145 A CN 200810084145A CN 101544572 B CN101544572 B CN 101544572B
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- amino
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- tertbutyloxycarbonyl
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
化合物 | 溶解度(mg/ml) |
L-丙氨酸[反式-4-[(2-氨基 -3,5-二溴苯甲基)氨基]环己醇]酯 二甲磺酸盐 | >500 |
L-缬氨酸[反式-4-[(2-氨基 -3,5-二溴苯甲基)氨基]环己醇]酯 二甲磺酸盐 | >500 |
盐酸氨溴索 | 13 |
化合物 | AUC0-t(ng.h/ml,平均 值) |
L-丙氨酸[反式-4-[(2- 氨基-3,5-二溴苯甲基)氨 基]环己醇]酯二甲磺酸盐 | 1017 |
盐酸氨溴索 | 868 |
Claims (12)
Priority Applications (1)
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CN2008100841459A CN101544572B (zh) | 2008-03-26 | 2008-03-26 | 一种氨溴索衍生物及其制备方法 |
Applications Claiming Priority (1)
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CN2008100841459A CN101544572B (zh) | 2008-03-26 | 2008-03-26 | 一种氨溴索衍生物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN101544572A CN101544572A (zh) | 2009-09-30 |
CN101544572B true CN101544572B (zh) | 2013-03-20 |
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CN2008100841459A Expired - Fee Related CN101544572B (zh) | 2008-03-26 | 2008-03-26 | 一种氨溴索衍生物及其制备方法 |
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CN (1) | CN101544572B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
CN102351720B (zh) * | 2011-10-21 | 2013-11-06 | 南京理工大学 | 一种简易高效的氨溴素合成方法 |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
ES2750523T3 (es) | 2012-12-18 | 2020-03-26 | Almirall Sa | Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3 |
CN103073439B (zh) * | 2013-02-05 | 2013-10-16 | 山东罗欣药业股份有限公司 | 一种盐酸氨溴索化合物的合成方法 |
TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽 |
TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有maba化合物和皮質類固醇之組合 |
TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物 |
CN112279774B (zh) * | 2019-07-24 | 2023-05-30 | 成都施贝康生物医药科技有限公司 | 二溴苄基衍生物、其立体异构体或其盐及制法和应用 |
CN112745251B (zh) | 2019-10-31 | 2023-10-27 | 华创合成制药股份有限公司 | 一种治疗祛痰化合物及其制备方法和用途 |
CN115108923A (zh) * | 2021-03-17 | 2022-09-27 | 成都施贝康生物医药科技有限公司 | 反式金刚烷氨衍生物或其盐、及制备方法、组合物和用途 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536713A (en) * | 1966-05-10 | 1970-10-27 | Boehringer Sohn Ingelheim | N-(hydroxy-cyclohexyl)-aminobenzylamines and the salts thereof |
EP0505180A1 (en) * | 1991-03-22 | 1992-09-23 | Merck & Co. Inc. | High-content ibuprofen lysinate pharmaceutical formulation |
CN1130354A (zh) * | 1993-09-07 | 1996-09-04 | 普罗克特和廿保尔公司 | 含有丙酸类非甾体消炎药氨基酸盐和减充血药、祛痰药、抗组胺药和镇咳药中至少一种的组合物 |
CN1454888A (zh) * | 2002-04-29 | 2003-11-12 | 常州市第四制药厂 | 快速溶解型氨溴索盐及制备方法 |
CN1699337A (zh) * | 2004-05-20 | 2005-11-23 | 江苏豪森药业股份有限公司 | 氨溴索半胱氨酸类似物盐及其制备方法和用途 |
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2008
- 2008-03-26 CN CN2008100841459A patent/CN101544572B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536713A (en) * | 1966-05-10 | 1970-10-27 | Boehringer Sohn Ingelheim | N-(hydroxy-cyclohexyl)-aminobenzylamines and the salts thereof |
EP0505180A1 (en) * | 1991-03-22 | 1992-09-23 | Merck & Co. Inc. | High-content ibuprofen lysinate pharmaceutical formulation |
CN1130354A (zh) * | 1993-09-07 | 1996-09-04 | 普罗克特和廿保尔公司 | 含有丙酸类非甾体消炎药氨基酸盐和减充血药、祛痰药、抗组胺药和镇咳药中至少一种的组合物 |
CN1454888A (zh) * | 2002-04-29 | 2003-11-12 | 常州市第四制药厂 | 快速溶解型氨溴索盐及制备方法 |
CN1699337A (zh) * | 2004-05-20 | 2005-11-23 | 江苏豪森药业股份有限公司 | 氨溴索半胱氨酸类似物盐及其制备方法和用途 |
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Publication number | Publication date |
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CN101544572A (zh) | 2009-09-30 |
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Owner name: JIANGSU HANSOH MEDICAL GROUP CO.,LTD. Free format text: FORMER OWNER: LIANYUNGANG HENGBANG PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20131113 |
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Effective date of registration: 20160315 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Patentee after: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL CO., LTD. Address before: 222047 Lianyungang Development Zone, Jiangsu Patentee before: Jiangsu Hansoh Medical Group Co.,Ltd. |
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