CN101537138A - Traditional Chinese medicine hepatitis B powder for eliminating duplication of hepatitis B virus (HBV) and method for manufacturing same - Google Patents
Traditional Chinese medicine hepatitis B powder for eliminating duplication of hepatitis B virus (HBV) and method for manufacturing same Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine hepatitis B powder for eliminating the duplication of hepatitis B virus (HBV) and a method for manufacturing the same. The traditional Chinese medicine hepatitis B powder for eliminating the duplication of hepatitis B virus (HBV) consists of the following medicaments of 2.6 percent of Bupleurum, 6.5 percent of radix scutellariae, 6.5 percent of radix isatidis, 4.3 percent of polyphylla, 2.6 percent of subprostrate sophora, 6.5 percent of selfheal, 3.8 percent of trumpetweed, 8.5 percent of dandelion, 8.5 percent of Ophiorrhiza pumila, 5 percent of fruit of glossy privet, 3.8 percent of processed rhizoma pinelliae, 7.7 percent of raw Atractylis ovata, 5 percent of raw yam, 6.5 percent of radix codonopsitis, 6.5 percent of glossy ganoderma, 5 percent of Salvia miltiorrhiza, 4.2 percent of rhizoma imperatae and 6.5 percent of medlar. The manufacturing method comprises the steps of selecting the medicaments, cleaning and drying, grinding the medicaments into powder and filling 9g of the medicine powder in every bag according to the above mass percent. Tested by clinical trial, the powder has the functions of clearing away heat and toxic material, reducing enzyme and eliminating jaundice, restricting the duplication of hepatitis B virus , enhancing immunologic function of bodies, restoring damaged stem cell, and preventing cirrhosis and liver cancer, and the like.
Description
Technical field
The present invention relates to a kind of medicine and manufacture method thereof, be specifically related to a kind of medicine and manufacture method thereof for the treatment of hepatitis B.
Technical background
Hepatitis B is a kind of worldwide disease that is caused by hepatitis B virus (HBV).Developing country's sickness rate height, according to statistics, the asymptomatic hepatitis B virus carriers in the whole world (HBsAg carrier) surpasses 2.8 hundred million, and China accounts for 9,300 ten thousand.Most asymptomatic, wherein 1/3 clinical manifestation that hepatic injury occurs.There is hepatitis B patient 3,000 ten thousand in China at present.The characteristics of hepatitis B are that onset is more slow, and are more common with subclinical type and chronic type.The easy chronicity of non-icteric type HBsAg lasting masculin person.
The medicine of treatment hepatitis B is many in the prior art, but still has limitation.Therefore China's Chinese medicine has special advantages, and developing a kind ofly has inhibitory action and do not have a Chinese patent medicine of toxin hepatitis B virus, to patient's Gospel beyond doubt.
Summary of the invention
The objective of the invention is to develop a kind of Chinese medicine that can effectively suppress hepatitis B virus (HBV) self replication, thereby reach the purpose of curing hepatitis B.
The present invention is achieved through the following technical solutions:
A kind of YIGAN SAN, selected Radix Bupleuri 2.6%, Radix Scutellariae 6.5%, Radix Isatidis 6.5%, Rhizoma Paridis 4.3%, Radix Sophorae Tonkinensis 2.6%, Spica Prunellae 6.5%, Herba Lycopi 3.8%, Herba Taraxaci 8.5%, Hedyotidis Diffusae 8.5%, Fructus Ligustri Lucidi 5%, Rhizoma Pinelliae Preparata 3.8%, Rhizoma Atractylodis Macrocephalae 7.7%, Rhizoma Dioscoreae 5%, Radix Codonopsis 6.5%, Ganoderma 6.5%, Radix Salviae Miltiorrhizae 5%, Rhizoma Imperatae 4.2%, Fructus Lycii 6.5% clean dryness in the sun, make Powderedly, be mixed with one bag of 9g according to the above ratio.
Pharmacological action is analyzed:
Radix Bupleuri is returned the liver and gall warp, and evacuation is brought down a fever, and reduces sero-enzyme AST, ALT, AKP and 5-activity of 5 '-nucleotidase, suppresses total bilirubin and rises and hepatic necrosis, and of the same race, homology cancerous cell beyond ehrlich carcinoma (EAC) and the EAC all are strong inhibitory action.
Radix Scutellariae, heat clearing and damp drying, eliminating fire and detoxication.Radix Scutellariae crude drug 1.0g/ml, 0.75g/ml, 0.5g/ml and 0.25g/ml all have an inhibitory action to the DNA of different in nature hepatitis virus (HBV) is synthetic.
Radix Isatidis, heat-clearing and toxic substances removing has tangible anti-endotoxin effect.Use the Radix Isatidis injection acupoint injection therapy, treatment hepatitis B virus surface antigen carrier 30 examples, HBsAg, HBeAg, HBV-DVA continue the person's of turning out cloudy 12 examples as a result; The HBsAg titre descends, and is stabilized in below 1: 64; HBeAg or HBV-DVA continue the person's of turning out cloudy 11 examples; The HBsAg titre descends and is stabilized in 1: 64 following or HBeAg, the anti-HBV-DVA3 item counter-rotating person's 6 examples.
Hedyotidis Diffusae, heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen.The Coumarins chemical compound is to solid type hepatocarcinoma, and the polysaccharide active component all has remarkable inhibitory action to the hypodermic type ehrlich carcinoma.
Herba Taraxaci is returned liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome is good for the stomach, function of gallbladder promoting, anti-tumor.
Radix Sophorae Tonkinensis, heat-clearing and toxic substances removing, detumescence, antiinflammatory.Use Sophora Tankinensis, general 2-4 week ALT can recover normally, and can improve serum albumin, reduces globulin, and HBsAg is also had the effect of necessarily turning out cloudy.
Spica Prunellae is returned liver, gallbladder meridian.Have relieve inflammation or internal heat, the merit of eliminating stagnation, detumescence.In vitro tests, Spica Prunellae decoct 3mg/ ware has significant anti-methylglyoxal and sodium azide mutagenic action, and mutation power is respectively 82.2% and 82.5%.Anti-immunodeficiency toxic action is arranged.
Fructus Ligustri Lucidi is returned liver, kidney channel.Fructus Ligustri Lucidi is given birth to product, wine product, and steamed product and ingredient oleanolic acid thereof all can reduce the serum alt value.Study on mechanism can suppress or alleviate hepatocellular degeneration or necrosis, promotes liver cell regeneration, quickens the reparation of non-viable non-apoptotic cell, suppresses the reaction of collagen fiber hypertrophy and specificity inflammation, so that liver cirrhosis is difficult to form the performance hepatoprotective effect.
Rhizoma Paridis is returned Liver Channel.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Rhizoma Paridis water extract (1g/ml) and 75%, 50%, 25% diluent thereof all have an inhibitory action, antitumor to the DNA of hepatitis B virus (BHV) is synthetic.
Rhizoma Imperatae, clearing away heat and promoting diuresis, cooling blood for hemostasis.With the sub-service of Rhizoma Imperatae 60g decocting, the treatment acute hepatitis, cardinal symptom disappears in 10d mostly, and hepatosplenomegaly disappears in 20d, and glutamate pyruvate transaminase (ALT) has 80% patient to reduce to normally behind 45d, and the about 20d of icteric index becomes a full member often entirely.
The Herba Lycopi returns the spleen Liver Channel.Be apt to into the liver spleen, promoting blood circulation to remove obstruction in the collateral, line water detumescence, but treating the liver stagnation of the blood void, stagnation of QI-blood and cause pain in chest and hypochondrium, distension do not relax.
Radix Salviae Miltiorrhizae, GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling is felt at ease with fixed attention.Be used for chronic hepatitis and early stage liver cirrhosis, but mitigation symptoms promotes the recovery of liver function and hepatosplenomegaly.
Ganoderma, human body immunity improving power is improved blood circulation, and detoxifcation promotes the hepatocyte synthetic protein, antitumor.
Fructus Lycii is returned liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Can strengthen cellular immunization and humoral immune function, strengthen the reticuloendothelial system phagocytic function, also have blood fat reducing, promote the liver cell regeneration effect.
Rhizoma Dioscoreae, lung is supported in spleen reinforcing, reinforces the kidney, and benefit is smart.The Rhizoma Dioscoreae infusion has the effect that promotes the interferon generation and increase the T cell.Pair cell immunity and humoral immune function have stronger facilitation.
Rhizoma Atractylodis Macrocephalae is fostered taste, helps digestion except that spleen, and diuresis increases albumin, corrects Archon albumen ratio, the liver protecting.
The Rhizoma Pinelliae, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Pinellin, polysaccharide, alkaloid all have antitumor action.
Radix Codonopsis, invigorating the spleen and replenishing QI, spermatogenesis nourishes blood.The promotion immunization of cell is arranged, can improve humoral immune function.
The invention has the beneficial effects as follows:
Through clinical trial, this powder has heat-clearing and toxic substances removing, and reducing enzyme and treating jaundice suppresses hepatitis B virus duplication, and the enhancing human body immunity function is repaired impaired stem cell, effects such as prevention liver cirrhosis, hepatocarcinoma formation.
The specific embodiment
A. selected medical material cleans up.
Medical material comprises: Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Rhizoma Paridis, Radix Sophorae Tonkinensis, Spica Prunellae, Herba Lycopi, Herba Taraxaci, Hedyotidis Diffusae, Fructus Ligustri Lucidi, Rhizoma Pinelliae Preparata, Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Codonopsis, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Imperatae, Fructus Lycii.
B. will clean clean medical material and carry out the dryness in the sun processing.
C. will carry out pulverization process through the medical material that dryness in the sun is handled, be made into powder.
D. the medicinal powder of making proportionally is mixed with 9g portion, bag distribution packaging.
Mass percent is: Radix Bupleuri 2.6%, Radix Scutellariae 6.5%, Radix Isatidis 6.5%, Rhizoma Paridis 4.3%, Radix Sophorae Tonkinensis 2.6%, Spica Prunellae 6.5%, Herba Lycopi 3.8%, Herba Taraxaci 8.5%, Hedyotidis Diffusae 8.5%, Fructus Ligustri Lucidi 5%, Rhizoma Pinelliae Preparata 3.8%, Rhizoma Atractylodis Macrocephalae 7.7%, Rhizoma Dioscoreae 5%, Radix Codonopsis 6.5%, Ganoderma 6.5%, Radix Salviae Miltiorrhizae 5%, Rhizoma Imperatae 4.2%, Fructus Lycii 6.5%.
Instructions about how to take medicine and consumption: oral, be grown up three times on the one, each one bag, child old man is cut down according to the circumstance.
The course of treatment: three months
Clinical application effect exemplifies:
Zhang, man, 21 years old.The hepatitis B great three positive, the People's Hospital, Siyang County on the 5th July in 2007 checks, HBV-DNA1.00E+05 copy/ml.On January 2nd, 2008, the People's Hospital, Siyang checks globulin 32.68g/l, surface antigen 1: 256 (blood clotting method).On February 17th, 2008, examine and see behind left thenar, the neck that a red point is respectively arranged, that presses fades the tongue no fur.Took YIGAN SAN 3 months.On May 11st, 2008, the People's Hospital, Siyang County checks that liver function is normal, HBV-DNA≤1.00E+03 copy/ml.
The Wang, man, 46 years old.Be diagnosed as hepatitis B in August, 1999, the first two years is a small three positive, after be great three positive always.Be diagnosed as liver cirrhosis in January, 2005.On April 13rd, 2007, the People's Hospital, Siyang County checks surperficial antigen 1: 256 (blood clotting methods).Cough vomiting bloody pus in mid-April, 2007, April 25, Siyang County Disease Control and Prevention Center was diagnosed as the tuberculosis pulmonary cavity, earlier based on the treatment pulmonary tuberculosis, and the removing heat from the liver of holding concurrently.Then based on the soft liver of liver heat removing, take into account and suppress tubercule bacillus behind the tuberculosis sx.Played the soft liver of clothes ginseng sesame diffusing (self-control) on May 17.Surface antigen on January 21st, 2008 rose on November 5th, 1: 8.2008 takes YIGAN SAN.2 days four March in 2009, sample county people's hospital was detected, HBV-DNA≤1.00E+03 copy/ml.
Claims (3)
1. eliminate Chinese medicine YIGAN SAN and the manufacture method thereof that hepatitis B virus (HBV) duplicates for one kind, it is characterized in that YIGAN SAN made by following medical material: Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Rhizoma Paridis, Radix Sophorae Tonkinensis, Spica Prunellae, Herba Lycopi, Herba Taraxaci, Hedyotidis Diffusae, Fructus Ligustri Lucidi, Rhizoma Pinelliae Preparata, Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Codonopsis, Ganoderma, Radix Salviae Miltiorrhizae, Rhizoma Imperatae, Fructus Lycii.
2. Chinese medicine YIGAN SAN and manufacture method thereof that a kind of elimination hepatitis B virus as claimed in claim 1 (HBV) duplicates is characterized in that: the mass percent of each medical material is as follows: Radix Bupleuri 2.6%, Radix Scutellariae 6.5%, Radix Isatidis 6.5%, Rhizoma Paridis 4.3%, Radix Sophorae Tonkinensis 2.6%, Spica Prunellae 6.5%, Herba Lycopi 3.8%, Herba Taraxaci 8.5%, Hedyotidis Diffusae 8.5%, Fructus Ligustri Lucidi 5%, Rhizoma Pinelliae Preparata 3.8%, Rhizoma Atractylodis Macrocephalae 7.7%, Rhizoma Dioscoreae 5%, Radix Codonopsis 6.5%, Ganoderma 6.5%, Radix Salviae Miltiorrhizae 5%, Rhizoma Imperatae 4.2%, Fructus Lycii 6.5% constitute.
3. Chinese medicine YIGAN SAN and manufacture method thereof that a kind of elimination hepatitis B virus as claimed in claim 1 (HBV) duplicates is characterized in that: concrete manufacture method is as follows:
A. selected above-mentioned medical material cleans up.
B. will clean clean medical material and carry out the dryness in the sun processing.
C. will carry out pulverization process through the medical material that dryness in the sun is handled, be made into powder.
D. the medicinal powder of making is mixed with 9g portion, bag distribution packaging according to aforementioned proportion.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105360787A (en) * | 2014-08-08 | 2016-03-02 | 深圳华大基因研究院 | Health food and preparation method thereof |
CN106265913A (en) * | 2016-08-25 | 2017-01-04 | 江苏天晟药业股份有限公司 | A kind of pharmaceutical composition containing monoammonium glycyrrhizinate and its preparation method and application |
CN111671749A (en) * | 2020-06-12 | 2020-09-18 | 重庆医科大学 | Application of dicoumarol in preparation of HBx protein stability inhibitor |
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CN101468185B (en) * | 2007-12-29 | 2011-04-20 | 牛海艳 | Quick-effective Chinese medicine preparation for expelling toxin of hepatitis B |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105360787A (en) * | 2014-08-08 | 2016-03-02 | 深圳华大基因研究院 | Health food and preparation method thereof |
CN106265913A (en) * | 2016-08-25 | 2017-01-04 | 江苏天晟药业股份有限公司 | A kind of pharmaceutical composition containing monoammonium glycyrrhizinate and its preparation method and application |
CN111671749A (en) * | 2020-06-12 | 2020-09-18 | 重庆医科大学 | Application of dicoumarol in preparation of HBx protein stability inhibitor |
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