CN101537005B - Codein and chlorphenamine compound sustained release capsules - Google Patents
Codein and chlorphenamine compound sustained release capsules Download PDFInfo
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- CN101537005B CN101537005B CN200910059141XA CN200910059141A CN101537005B CN 101537005 B CN101537005 B CN 101537005B CN 200910059141X A CN200910059141X A CN 200910059141XA CN 200910059141 A CN200910059141 A CN 200910059141A CN 101537005 B CN101537005 B CN 101537005B
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Abstract
The invention discloses codein and chlorphenamine compound sustained release capsules. The sustained release granules are made from the following raw materials by weight: 10-11.1 parts of codein, 2-2.2 parts of chlorphenamine, 1-2 parts of a lubricant, 18.9-86 parts of a sustained release matrix material and 0-12.4 parts of a filling agent. The sustained release matrix material is two or three of hydroxypropyl emthylcellulose, acrylic resin and ethyl cellulose, wherein, the acrylic resin and the ethyl cellulose totally accounts for 10.9-31.5%. The capsules are obtained by the following steps: evenly mixing the codein, the chlorphenamine and the sustained release matrix material; adding a binder to prepare a soft material and sieving with a 6-24-mesh sieve; preparing damp granules, drying and granulating; and adding the lubricant, evenly mixing and then encapsulating to obtain the finished product.
Description
Technical field:
The present invention relates to a kind of dosage form of medicine, relate in particular to a kind of compound medicine slow releasing capsule and preparation method thereof.
Background technology:
Codeine can directly suppress the coughing centre of medulla oblongata as a kind of opiates analgesia cough suppressing medicine, and antitussive action is rapid and powerful, is applicable to violent dry cough and irritable cough that a variety of causes causes, is particularly useful for the violent dry cough with chest pain.The codeine oral absorption is fast and fully, its bioavailability is 40%～70%, once oral 15mg after about 1 hour blood drug level reach the peak, the half-life is about 3～4 hours.Mainly combine with glucuronic acid at liver, about 15% becomes morphine through demethylation.Its metabolite is mainly through homaluria.
Chlorphenamine is an azanol class antihistaminic, is characterized in that antihistamine effect is stronger, and consumption is little, few side effects.Clinically be used for treatments such as various anaphylactic diseases, insect bite and drug anaphylaxis, be used for the treatment of flu with the antipyretic analgesic compatibility.The chlorphenamine oral absorption is slower, and bioavailability is 25%～50%.Protein binding rate is 72%.Onset in oral back 60 minutes, 3～6 hours peakings of blood drug level.Mainly through hepatic metabolism, former medicine and metabolite are all discharged through urine, and the half-life is 12～15 hours.
Codeine mainly is used for the cough-relieving treatment with common oral administered compound solution at present, this dosage form is mainly utilized ion-exchange resin technique, by with codeine and ion exchange resin generation ion-exchange reactions, generate resin complexes, after orally using, utilize the ionic environment in the gastrointestinal tract that medicine is cemented out, the performance drug effect.This kind oral administration solution needs inferior more than a day taking, and causes abuse easily, produces addiction and dependency.
At this situation, developed compound recipe codeine release oral solution kind abroad, U.S. Pat 3594470 discloses a kind of with codeine resin complexes dressing microcapsuleization, thereby makes it have slow release effect, obtains one day and need take twice compound sustained-released oral administration solution.Chinese patent 200510102145.3 discloses and a kind ofly will prepare the method for slow-release suspension behind the codeine resin complexes coating.Carry and take inconvenience, slow release effect is still undesirable.
At present, the preparation slow releasing capsule is many with the preparation slow-release micro-pill, obtains after the filling.Slow-release micro-pill can by extrude spheronization be prepared into the skeleton micropill or by blank pill in the heart behind the medicine coating prepare film control micropill and get.Chinese patent 2003141741.8 wraps the extended release coatings film again and makes slow-release micro-pill after disclosing a kind of use microcrystalline Cellulose blank pill heart channel fluidization medicine-feeding, obtains the metformin slow releasing capsule behind the filling capsule.Chinese patent 200138479.7 discloses a kind of diclofenac sodium slow releasing capsule and preparation technology thereof, and preparation technology comprises the preparation blank pill heart, prepares plain ball, coating and encapsulated.
Framework materials such as use HPMC prepare slow-releasing granules, directly load capsule and can obtain slow releasing capsule, and its preparation technology is simple, and slow release effect is good.Chinese patent 200410066423.X discloses a kind of oral capsular preparation method of antidiabetic drug gliclazide that is used for, and this method has been used framework material hydroxypropyl methylcellulose K4M, and the capsule that makes has certain slow releasing function.
The slow releasing capsule of using this method to make can not satisfy the requirement of codeine release.
Summary of the invention:
It is suitable to the purpose of this invention is to provide a kind of codeine and chlorphenamine drug release rate, the availability height, and medicining times is few, and side effect is little, and preparation technology is simple, codeine easy to carry and use and chlorphenamine compound sustained release capsules.
The present invention is achieved in that
Codeine of the present invention and chlorphenamine compound sustained release capsules, slow-releasing granules is made by the raw material that comprises following weight portion:
Codeine 10～11.1,
Chlorphenamine 2～2.2,
Lubricant 1～2,
Skeleton slow-release material 77.9～85.3,
Filler 0～12.4,
Binding agent is an amount of.
Described skeleton slow-release material all contains hydroxypropyl methylcellulose, and contain in acrylic resin and the ethyl cellulose one or both, when acrylic resin and ethyl cellulose all contain sometimes, the weight of acrylic resin and ethyl cellulose and account for 21～30% of skeleton slow-release material gross weight, the described binding agent concentration that is weight percentage is 5～10% polyvinylpyrrolidone ethanol water, described lubricant is one or more in magnesium stearate, the Pulvis Talci, and described filler is one or more in starch, lactose, the calcium hydrogen phosphate.
Described hydroxypropyl methylcellulose is one or more among hydroxypropyl methylcellulose K4M, hydroxypropyl methylcellulose K15M, the hydroxypropyl methylcellulose K100M.
Described acrylic resin is acrylic resin RSPO; Described ethyl cellulose is ethyl cellulose 45cp.
Capsular preparation method, step is as follows: with codeine, chlorphenamine, skeleton slow-release material mix homogeneously adds binding agent and makes soft material, crosses 6～24 mesh sieves, the system wet granular, drying, granulate adds lubricant, and is encapsulated behind the mixing, promptly.
The present invention is selected three kinds of skeleton slow-release materials, use different skeleton slow-release materials by uniting, and the ratio that changes different skeleton slow-release materials is regulated the diffusion velocity of compound medicine in the skeleton, the speed release to suit in whole gastrointestinal tract of control compound medicine.Capsules preparation technique of the present invention is simple, selection with 8%PVP K-30 ethanol water as binding agent, make regular granule, uniformity of dosage units meets the requirements after loading capsule, slow release effect is good: 1 hour release of codeine is 28～35%, 4 hours releases are 55～65%, and release 75～85% in 8 hours, and release was more than 90% in 12 hours; 1 hour release of chlorphenamine is 20～30%, and 4 hours releases are 50～60%, and release 70～80% in 8 hours, and release was more than 85% in 12 hours.The drug bioavailability height, medicining times is few, has reduced addiction and other side effect of medicine.
The specific embodiment:
The present invention is described in detail with the following Examples
Embodiment 1:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10.6%, chlorphenamine maleate 2.1%, hydroxypropyl methylcellulose K-4M 74.5%, acrylic resin RSPO 10.8%, magnesium stearate 2%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-4M, acrylic resin RSPO are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (6: 4) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
It is harder to make granule, and content is 0.188g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 25～35%, release was 55～65% in 4 hours, release 70～80% in 8 hours, and release was more than 85% in 12 hours; Chlorphenamine discharged hour release in 1 hour more than 80%.
Embodiment 2:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10.6%, chlorphenamine maleate 2.1%, hydroxypropyl methylcellulose K-15M 63.8%, acrylic resin RSPO 21.5%, magnesium stearate 2%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-15M, acrylic resin RSPO, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (6: 4) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 60 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
It is more to make particle powder, and content is 0.188g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 25～35%, release was 50～65% in 4 hours, release 70～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 25～35%, and 4 hours releases are 50～60%, and release 70～80% in 8 hours, and release was more than 85% in 12 hours.
Embodiment 3:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10.6%, chlorphenamine maleate 2.1%, hydroxypropyl methylcellulose K-100M 53.8%, acrylic resin RSPO 31.5%, magnesium stearate 2%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-100M, acrylic resin RSPO, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (6: 4) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 60 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
It is more to make particle powder, and content is 0.188g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 25～35%, release was 55～65% in 4 hours, release 75～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 25～35%, and 4 hours releases are 50～65%, and release 70～85% in 8 hours, and release was more than 85% in 12 hours.
Embodiment 4:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 11.1%, chlorphenamine maleate 2.2%, hydroxypropyl methylcellulose K-15M 61.2%, acrylic resin RSPO 18.9%, lactose 5.6%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-15M, acrylic resin RSPO, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 60 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.1800g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 25～30%, release was 55～65% in 4 hours, release 75～85% in 8 hours, and release was more than 90% in 12 hours.1 hour release of chlorphenamine is 20～25%, and 4 hours releases are 45～55%, and release 65～75% in 8 hours, and release was more than 80% in 12 hours.
Embodiment 5:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-100M 60%, acrylic resin RSPO 20%, lactose 6%, magnesium stearate 2%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-100M, acrylic resin RSPO, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 60 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 28～33%, release was 55～65% in 4 hours, release 75～85% in 8 hours, and release was more than 90% in 12 hours; 1 hour release of chlorphenamine is 20～30%, and 4 hours releases are 50～60%, and release 70～80% in 8 hours, and release was more than 85% in 12 hours.
Embodiment 6:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 11.1%, chlorphenamine maleate 2.2%, hydroxypropyl methylcellulose K-15M 61.2%, ethyl cellulose 45cp 16.7%, lactose 7.8%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-15M, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 60 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.1800g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 28～32%, release was 55～65% in 4 hours, release 72～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 20～30%, and 4 hours releases are 50～60%, and release 65～75% in 8 hours, and release was more than 80% in 12 hours.
Embodiment 7:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-100M 60%, ethyl cellulose 45cp 20%, lactose 7%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-100M, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 25～32%, release was 55～60% in 4 hours, release 70～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 18～25%, and 4 hours releases are 45～55%, and release 60～70% in 8 hours, and release was more than 75% in 12 hours.
Embodiment 8:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-100M 50%, ethyl cellulose 45cp 30%, lactose 7%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-100M, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 30～35%, release was 50～60% in 4 hours, release 75～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 20～30%, and 4 hours releases are 40～55%, and release 65～75% in 8 hours, and release was more than 80% in 12 hours.
Embodiment 9:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-4M 60%, acrylic resin RSPO 13%, ethyl cellulose 45cp 8%, lactose 6%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-4M, acrylic resin RSPO, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 30～38%, release was 55～70% in 4 hours, release 75～85% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 25～35%, and 4 hours releases are 50～65%, and release 70～80% in 8 hours, and release was more than 85% in 12 hours.
Embodiment 10:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-15M 53%, acrylic resin RSPO 15%, ethyl cellulose 45cp 12%, lactose 7%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-15M, acrylic resin RSPO, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 30～35%, release was 55～65% in 4 hours, release 75～85% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 25～30%, and 4 hours releases are 45～60%, and release 60～75% in 8 hours, and release was more than 80% in 12 hours.
Embodiment 11:
Compound recipe codeine slow releasing capsule of the present invention is formed (percentage by weight, as follows): codeine phosphate 10%, chlorphenamine maleate 2%, hydroxypropyl methylcellulose K-100M 50%, acrylic resin RSPO 16%, ethyl cellulose 45cp 13%, lactose 8%, magnesium stearate 1%.
Preparation method is: recipe quantity codeine phosphate, chlorphenamine maleate, hydroxypropyl methylcellulose K-100M, acrylic resin RSPO, ethyl cellulose 45cp, lactose are crossed 80 mesh sieves respectively, put the mixer mix homogeneously, the ethanol water (7: 3) that adds 8%PVP is made soft material as binding agent and stirring, crossing 18 mesh sieves granulates, 50 ℃ of dryings of granule 1 hour, 18 order granulate add the magnesium stearate of recipe quantity again, mixing, encapsulated.
Implementation result:
Make regular granule, content is 0.200g.According to 2005 editions two appendix XE uniformity of dosage units of Chinese Pharmacopoeia inspection technique regulation, uniformity of dosage units meets the requirements.According to 2005 editions two appendix XIXD sustained-release preparations of Chinese Pharmacopoeia guideline, the drug release determination method of XD drug release determination method first law regulation, 1 hour release of codeine is 28～35%, release was 50～60% in 4 hours, release 70～80% in 8 hours, and release was more than 85% in 12 hours; 1 hour release of chlorphenamine is 20～30%, and 4 hours releases are 45～55%, and release 65～75% in 8 hours, and release was more than 80% in 12 hours.
Claims (4)
1. codeine and chlorphenamine compound sustained release capsules is characterized in that slow-releasing granules made by the raw material that comprises following weight portion:
Codeine 10～11.1,
Chlorphenamine 2～2.2,
Lubricant 1～2,
Skeleton slow-release material 77.9～85.3,
Filler 0～12.4,
Binding agent is an amount of.
Described skeleton slow-release material all contains hydroxypropyl methylcellulose, and contain in acrylic resin and the ethyl cellulose one or both, when acrylic resin and ethyl cellulose all contain sometimes, the weight of acrylic resin and ethyl cellulose and account for 21～30% of skeleton slow-release material gross weight, the described binding agent concentration that is weight percentage is 5～10% polyvinylpyrrolidone ethanol water, described lubricant is one or more in magnesium stearate, the Pulvis Talci, and described filler is one or more in starch, lactose, the calcium hydrogen phosphate.
2. capsule according to claim 1 is characterized in that described hydroxypropyl methylcellulose is one or more among hydroxypropyl methylcellulose K4M, hydroxypropyl methylcellulose K15M, the hydroxypropyl methylcellulose K100M.
3. capsule according to claim 1 is characterized in that described acrylic resin is acrylic resin RSPO; Described ethyl cellulose is ethyl cellulose 45cp.
4. according to the described capsular preparation method of claim 1, it is characterized in that step is as follows: with codeine, chlorphenamine, skeleton slow-release material mix homogeneously, add binding agent and make soft material, cross 6～24 mesh sieves, system wet granular, drying, granulate adds lubricant, and is encapsulated behind the mixing, promptly.
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| CN200910059141XA CN101537005B (en) | 2009-04-29 | 2009-04-29 | Codein and chlorphenamine compound sustained release capsules |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273091A (en) * | 2000-04-07 | 2000-11-15 | 成都亨达制药厂 | Slowly releasing piperazine ferulate |
| CN1820752A (en) * | 2005-12-02 | 2006-08-23 | 深圳市制药厂 | Oral liquor slow releasing preparation containing codeine and chlorophenamine and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273091A (en) * | 2000-04-07 | 2000-11-15 | 成都亨达制药厂 | Slowly releasing piperazine ferulate |
| CN1820752A (en) * | 2005-12-02 | 2006-08-23 | 深圳市制药厂 | Oral liquor slow releasing preparation containing codeine and chlorophenamine and its preparing method |
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Effective date of registration: 20190927 Address after: 518118 Guangdong city of Shenzhen province Pingshan Qing Lan 18 three-way Patentee after: Guoyao Group Zhijun (Shenzhen) Pingshan Pharmaceutical Co., Ltd. Address before: 610052, No. 168, Zhonghe Road, Longtan Industrial Park, two section of East Third Ring Road, Sichuan, Chengdu Patentee before: Sichuan Industrial institute of antibiotics Co., Ltd. |
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