CN101530102B - Sterilization composition containing fenbuconazole and thiophonate-methyl and application thereof - Google Patents
Sterilization composition containing fenbuconazole and thiophonate-methyl and application thereof Download PDFInfo
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- CN101530102B CN101530102B CN2008102120021A CN200810212002A CN101530102B CN 101530102 B CN101530102 B CN 101530102B CN 2008102120021 A CN2008102120021 A CN 2008102120021A CN 200810212002 A CN200810212002 A CN 200810212002A CN 101530102 B CN101530102 B CN 101530102B
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Abstract
The invention provides a sterilization composition containing fenbuconazole and thiophonate-methyl. The effective components of the composition consist of the fenbuconazole and the thiophonate-methyl. The sterilization composition has obvious synergy and little dosage, is not easy to produce drug resistance by continuous use, is applicable to preventing various crop diseases, and is particularly applicable to controlling alternaria leaf spot of apple trees.
Description
Technical field
The invention belongs to technical field of pesticide, being specifically related to a kind of is the bactericidal composition and the application thereof of main active with RH-7592 and thiophanate-methyl.
Background technology
RH-7592 (fenbuconazole) colourless crystallization, fusing point 124-1 ℃, vapour pressure 0.005mpa (20 ℃), solvability 0.2mg/L in the water (2 ℃).Can be dissolved in most of organic solvents, in acetone, ether, ethanol and aromatic hydrocarbon, be insoluble in the aliphatic hydrocarbon.Under 300 ℃, stable in the dark.RH-7592 is the triazole type systemic fungicide, belongs to a kind of brand-new ergosterol biosynthesis inhibitor (EBI), has protection concurrently, cures the disease and killing action, and the energy that destroys germ by the respiration that suppresses germ synthesizes and loss of life power.RH-7592 has good crop safety and very outstanding Environmental compatibility.For obtaining best preventive effect, in the dispenser of disease initial stage of origination, should note filling up the water yield during spraying, the crop surface soup is fully covered.
RH-7592 is by The Dow Agrosciences, LLC.'s development product, and formulation products is 24% RH-7592 suspending agent, is mainly used in control vegetables, diseases of garden stuff, because its drug cost height uses not extensive.
Thiophanate-methyl (thiophanate-methyl) is a kind of efficient, low toxicity bactericide, has prevention and systemic action, because of medicament can change into carbendazim after entering in the plant corpus, so also belong to benzimidazole.Can be widely used in multiple diseases such as grain, cotton, oil, vegetables, fruit tree.Can prevent and treat gibberella zeaze petch of wheat and barley, stinking smut, wheat powdery mildew, leaf blast disease, the rice sheath blight, sclerotinia rot of colza etc.Can be used for sweet potato smut, the big leaf spot of corn, rice purple stalk disease, head smut of sorghum in addition.Thiophanate-methyl for a long time, repeatedly uses on Crop in China, and this makes the target germ strengthen gradually its resistance, and the cost that makes thiophanate-methyl prevent and treat disease increases and drug effect reduces greatly.
Summary of the invention
The objective of the invention is provides a kind of applied widely, plant sterilization composition that contains RH-7592 and thiophanate-methyl that cost is low, effective at above-mentioned technical problem.
A further object of the invention provides the purposes of this bactericidal composition.
The objective of the invention is to realize by following measures:
A kind of bactericidal composition, active ingredient is made up of RH-7592 and thiophanate-methyl, the percentage by weight of RH-7592 and thiophanate-methyl is 1～70:10～70, and through formulation screening test, the optimum percentage by weight of RH-7592 and thiophanate-methyl is 10～30:15～60.
Bactericidal composition of the present invention, wherein auxiliary agent and composite its active constituent content of water dispersible granules, suspending agent or wetting powder of making of excipient of RH-7592 and thiophanate-methyl and routine are 10%～70%.
Described water dispersible granules comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
1 part～12 parts of dispersants;
1 part～5 parts of wetting agents;
1 part～5 parts of disintegrants;
1 part～5 parts of binding agents;
Filler adds to 100 parts.
Wherein, dispersant is selected from sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, two naphthyl sulfonate, acrylic acid polymers sodium salt, laruyl alcohol according in the oxygen vinethene one or more;
Described wetting agent is selected from lauryl sodium sulfate, draws back powder, among the wetting and penetrating agent F, spaonin powder, bay alcohol radical sodium sulphate, neopelex, alkylbenzenesulfonate one or more;
Described disintegrant is selected from one or more in ammonium sulfate, aluminium chloride, citric acid, succinic acid, the carbonic hydroammonium;
Described adhesive is selected from one or more in polyethylene glycol, polyvinyl alcohol, the polyvinylpyrrolidone;
Described carrier is selected from one or more in kaolin, diatomite, white carbon, the bentonite;
Above-mentioned formulation material is mixed, pulverize,, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis is made water dispersible granules product of the present invention through mediating with micro jet.
Described suspending agent comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
2 parts～10 parts of dispersants;
0.1 part～1 part of thickener;
0.1 part～1 part of defoamer;
1 part～10 parts of antifreezing agents;
0 part～5 parts of stabilizing agents
Add water to 100 parts.
Described dispersant is selected from one or more in sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, lignin calcium iodate, lauryl alcohol polyethylene glycol oxide base ether sodium sulfate, alkyl naphthalene formaldehyde condensate sulfonates, neopelex, lauryl sodium sulfate, potassium oleate, enuatrol, alkyl polyoxyethylene ether sulfonate, the alkylphenol-polyethenoxy base ether formaldehyde condensation products;
Described thickener is selected from one or more in xanthans, methylcellulose, Magnesiumaluminumsilicate or the polyvinyl alcohol;
Described defoamer is selected from one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound;
Described antifreezing agent is selected from one or more in ethylene glycol, glycerine, propane diols, glycerine, polyethylene glycol or the sorbierite;
Described stabilizing agent is selected from one or more among alkyl phosphate, phosphorous acid esters, polyalcohol, alkyl sulfonic ester, the BHT;
With above-mentioned formulation material, thickener and antifreezing agent are mixed back all the other components except that crossing active ingredient, mix through high speed shear, add active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes the suspending agent product of mixture of the present invention.
Described wetting powder comprises the component of following weight portion:
1 part～70 parts of RH-7592;
10 parts～70 parts of thiophanate-methyls;
1 part～15 parts of dispersants;
1 part～15 parts of wetting agents;
Filler adds to 100 parts.
Wherein, dispersant is selected from sodium lignin sulfonate, NO, NNO, carboxymethyl cellulose, two naphthyl sulfonate, acrylic acid polymers sodium salt, laruyl alcohol according in the oxygen vinethene one or more;
Described wetting agent is selected from lauryl sodium sulfate, draws back powder, among the wetting and penetrating agent F, spaonin powder, bay alcohol radical sodium sulphate, neopelex, alkylbenzenesulfonate one or more;
Described filler is mineral carrier or synthetic vectors, one or more in available kaolin, diatomite, the white carbon;
Above-mentioned formulation material is mixed, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder product of the present composition.
Bactericidal composition of the present invention is having fabulous effect aspect control cereal class, melon and fruit or the vegetable crop disease.
The invention has the advantages that: utilize two kinds of synergistic functions that active component is mixed and is produced, improved preventive effect, delay the generation of pest resistance to insecticide, reduced the consumption of active ingredient, reduced peasant's use cost and reduced to the pollution of environment with to operating personnel's danger coefficient.
Specific embodiments
The invention will be further described below in conjunction with embodiment.The preparation method of formulation is conventional method among the embodiment.
Embodiment 1 25% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 3g, thiophanate-methyl 22g, two sodium naphthasulfonate 5g, spaonin powder 3g, citric acid 3g, polyethylene glycol 1g, kaolin add to 100g, the mixed 25% worm RH-7592 thiophanate-methyl water dispersible granules that gets.
Embodiment 2 40% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 5g, thiophanate-methyl 35g, sodium lignin sulfonate 8g, neopelex 2g, polyvinyl alcohol 2g, carbonic hydroammonium 2g, bentonite 15g, kaolin are added to 100g, make 40% RH-7592 thiophanate-methyl water dispersible granules through pulverizing granulation.
Embodiment 3 55% RH-7592 thiophanate-methyl water dispersible granules
RH-7592 15g, thiophanate-methyl 40g, carboxymethyl cellulose 10g, neopelex 3g, polyvinyl alcohol 1g, succinic acid 3g, white carbon 15g, kaolin are added to 100g, make 55% RH-7592 thiophanate-methyl water dispersible granules through pulverizing granulation.
Embodiment 4 15% RH-7592 thiophanate-methyl suspending agents
RH-7592 3g, thiophanate-methyl 12g, neopelex 8g, xanthans 0.3g, organic silicone 0.5g, ethylene glycol 5g, water adds to 100g, the mixed 15% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 5 30% RH-7592 thiophanate-methyl suspending agents
RH-7592 5g, thiophanate-methyl 25g, sodium lignin sulfonate 5g, Magnesiumaluminumsilicate 0.5g, organic silicone 0.5g, polyethylene glycol 4g, water adds to 100g, the mixed 30% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 6 45% RH-7592 thiophanate-methyl suspending agents
RH-7592 7g, thiophanate-methyl 38g, SDS 8g, polyvinyl alcohol 0.6g, organic silicone 0.6g, propane diols 6g, water adds to 100g, the mixed 45% RH-7592 thiophanate-methyl suspending agent that gets.
Embodiment 7 20% RH-7592 thiophanate-methyl wetting powders
RH-7592 5g, thiophanate-methyl 15g, neopelex 5g, spaonin powder 4g, white carbon 5g, bentonite adds to 100g, the mixed 20% RH-7592 thiophanate-methyl wetting powder that gets.
Embodiment 8 50% RH-7592 thiophanate-methyl wetting powders
With RH-7592 10g, thiophanate-methyl 40g, neopelex 2g, dispersing agent NNO 4g, white carbon 10g, kaolin adds to 100g, and mixture carries out comminution by gas stream, makes 50% RH-7592 thiophanate-methyl wetting powder.
Embodiment 9 70% RH-7592 thiophanate-methyl wetting powders
RH-7592 10g, thiophanate-methyl 60g, dispersing agent NNO 8g, bay alcohol radical sodium sulphate 5g, white carbon 100g are mixed, make 70% RH-7592 thiophanate-methyl wetting powder.
Application Example one
Test with the pesticidal preparations control alternaria leaf spot of apple that the foregoing description makes.
1, test is handled this test medicine consumption and is established three concentration of treatment respectively according to the difference of each composition, and the contrast medicament is respectively commercially available agricultural chemicals 70% thiophanate-methyl wetting powder and 24% RH-7592 suspending agent and the test of blank clear water.
2, each sub-district one-tenth fruit tree in age of test method is no less than 6 strains, repeats 3 times; Detecting the control efficiency method before the dispenser after investigation and the dispenser is: investigation two strains in every sub-district, every strain press East, West, South, North, in 5 the investigation 2 current-year branches whole blades, write down total number of sheets, the sick number of sheets and scab number, detect the spot defoliation occurrence degree.
3, result of the test such as following table 1:
The field control effectiveness test result of 1～9 pair of alternaria leaf spot of apple of table 1 embodiment
Application Example two
RH-7592 and thiophanate-methyl different proportion are mixed to alternaria leaf spot of apple Toxicity Determination and formulation screening test.
Determine that through trial test two medicaments roughly after the valid density scope, establish 5 assembly ratio with RH-7592 and thiophanate-methyl by active ingredient, each single agent and different proportioning are respectively established 5 concentration gradients and are handled.Adopting the mycelial growth rate method, with alternaria leaf spot of apple germ bacterial strain PDA medium culture, treat that bacterium colony grows to culture dish 3/4ths when big or small, is that the card punch of 5mm punches from the edge with internal diameter, and the mycelia piece that breaks into is as inoculum.Get the soup 3ml for preparing respectively and evenly mix with quantitative 27ml sterilising medium, pour in 3 sterilization culture dishes, make the pastille flat board after the cooling, be mixed into contrast with equivalent aqua sterilisa and medium, 3 repetitions are established in every processing.To inoculate mycelia and be inverted in dull and stereotyped central authorities, and put into 27 ℃ of incubators and cultivate.Measure colony diameter with the right-angled intersection method behind the 120h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.Computing formula is as follows:
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Simultaneously calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 be an antagonism, and 0.5≤SR≤1.5 are summation action, SR〉1.5 be synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively RH-7592 and thiophanate-methyl shared ratio in composition
A is a RH-7592
B is a thiophanate-methyl
Experimental result and analysis
Table 2 RH-7592 and thiophanate-methyl and be mixed to apple tree spot defoliation measurement result analytical table
| Reagent agent | Toxicity regression formula (y=a+bx) | EC 50(μ g/ml) (observed value) | EC 50(μ g/ml) (theoretical value) | Synergy ratio (SR) |
| RH-7592 | y＝5.0798+1.0935x | 0.60 | — | — |
| Thiophanate-methyl | y＝4.8514+1.3370x | 1.49 | — | — |
| RH-7592: first sulphur (3:22) | y＝4.9254+1.0445x | 1.11 | 1.26 | 1.14 |
| RH-7592: first sulphur (7:38) | y＝5.0005+0.9305x | 0.87 | 1.21 | 1.39 |
| RH-7592: first sulphur (10:40) | y＝5.0302+0.8999x | 0.71 | 1.15 | 1.62 |
| RH-7592: first sulphur (15:40) | y＝5.0586+0.8925x | 0.62 | 1.06 | 1.71 |
| RH-7592: first sulphur (10:60) | y＝5.0489+0.9039x | 0.75 | 1.23 | 1.64 |
As shown in Table 2, RH-7592 and thiophanate-methyl suppress the EC of alternaria leaf spot of apple
50Value is respectively 0.60 μ g/ml, 1.49 μ g/ml, shows that the virulence of RH-7592 is higher than the virulence of thiophanate-methyl.RH-7592 and thiophanate-methyl are used the inhibition alternaria leaf spot of apple with 3:22,7:38,10:40,15:40,10:60 ratio, and its synergy ratio is respectively 1.14,1.39,1.62,1.71,1.64, and certain synergistic effect is all arranged.
Field efficacy and toxicity test result show that RH-7592 and thiophanate-methyl composition have good control efficiency to alternaria leaf spot of apple, and control efficiency all is better than single agent kind.
Claims (3)
1. bactericidal composition is characterized in that active ingredient is made up of RH-7592 and thiophanate-methyl, and wherein RH-7592 and thiophanate-methyl weight ratio are 10: 60 or 10: 40 to 15: 40.
2. bactericidal composition according to claim 1 is characterized in that: RH-7592 and thiophanate-methyl and conventional insecticides adjuvant and composite wetting powder, suspending agent or the water dispersible granules made of excipient.
3. the application of bactericidal composition according to claim 1 aspect control fruit tree or vegetable crop disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008102120021A CN101530102B (en) | 2008-09-11 | 2008-09-11 | Sterilization composition containing fenbuconazole and thiophonate-methyl and application thereof |
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| CN101530102B true CN101530102B (en) | 2011-09-21 |
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| CN102067861A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Fenbuconazole-containing bactericidal composition |
| CN102057916A (en) * | 2011-01-21 | 2011-05-18 | 陕西美邦农药有限公司 | Bactericidal composition containing fenbuconazole and strobilurin compound |
| CN102150683B (en) * | 2011-03-03 | 2013-10-09 | 陕西美邦农药有限公司 | Fenbuconazole-containing synergic sterilization composition |
| CN102177899A (en) * | 2011-03-05 | 2011-09-14 | 陕西美邦农药有限公司 | Antibacterial composition containing fenbuconazole and triazole compound |
| CN102165957B (en) * | 2011-03-05 | 2014-03-05 | 陕西美邦农药有限公司 | Synergic sterilizing composite containing fenbuconazole and triazole compound |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1813152A1 (en) * | 2006-01-30 | 2007-08-01 | Basf Aktiengesellschaft | Fungicidal mixture based on 3,4-disubstituted biphenylanilides |
| WO2007104669A3 (en) * | 2006-03-14 | 2008-02-21 | Basf Ag | Method of inducing virus tolerance of plants |
| CN101171921A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of metiram |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1813152A1 (en) * | 2006-01-30 | 2007-08-01 | Basf Aktiengesellschaft | Fungicidal mixture based on 3,4-disubstituted biphenylanilides |
| WO2007104669A3 (en) * | 2006-03-14 | 2008-02-21 | Basf Ag | Method of inducing virus tolerance of plants |
| CN101171921A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of metiram |
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Effective date of registration: 20161221 Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Patentee after: Shaanxi Meibang Pesticides Co., Ltd. Address before: 715500 Pucheng province Shaanxi County Chengguan Town Food City Street No. 23 Patentee before: Zhang Shaowu |
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Granted publication date: 20110921 Termination date: 20170911 |