CN101524490A - Chinese medicinal composition for treating anemia and preparation method thereof - Google Patents
Chinese medicinal composition for treating anemia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating anemia, which is prepared from lotus seed, coix seed, ginseng, largehead atractylodes rhizome, liquorice root, Chinese angelica, Indian buead, motherwort herb, szechuan lovage rhizome, dioscorea, gordon euryale seed, radix astragali, moutan, fresh rehmannia, lycium bark, figwort root, white paeony root, Chinese wolfberry, hairy antler and/or a pharmaceutically acceptable carrier. The invention also relates to a preparation method for the Chinese medicinal composition. The Chinese medicinal composition has the efficacies in invigorating the spleen and tonifying the kidney, and invigorating the vital energy and nourishing the blood, and is used for symptoms such as deficiency of the liver and kidney, dim complexion, a dizzy head and blurred eyes, palpitation and shortness of breath, insomnia and forgetfulness, limb numbness and the like caused by the anemia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of anemia and preparation method thereof.
Background technology
Anemia is meant the subnormal pathological state of hemoglobin content, RBC number and packed cell volume in the unit volume blood circulation.The range of normal value of these indexs is different slightly variant because of area, nationality and sex etc.The general non-highlands of China, non-adult male, hemoglobin concentration is lower than 120g/L, and RBC number is lower than 4 * 10
12/ L, or packed cell volume is lower than 0.40; Adult female's hemoglobin concentration is lower than 105g/L, and RBC number is lower than 3.5 * 10
12/ L or erythrocyte force down in 0.35, can be considered anemia.The child is more lower slightly than man normal value below 12 years old, can allow to reduce about 15% the both sexes no significant difference at most.Occupy the highlands person for a long time, because the anoxia hemopoietic, its every index value is then slightly high.In having or not on this point of measurement anemia, among this three of hemoglobin concentration, RBC number and packed cell volume, being lower than with hemoglobin concentration normally is the most basic important indicator, because it more can reflect the essence of anemia.Whether accurately reflection exists or the degree of anemia and RBC number differs surely under certain conditions.Such as, when microcytic hypochromic anemia, it is lighter that the RBC number purpose reduces the degree that lowers than hemoglobin, so that anemia is when light, and red blood cell count(RBC) still can be normal; On the contrary, during the maxicell anemia, the minimizing of red blood cell count(RBC) is more more remarkable than the degree that hemoglobin lowers, when red blood cell count(RBC) a little less than just often, hemoglobin concentration can be still in normal range.The degree of anemia, generally can divide by the degree that hemoglobin concentration lowers: be lower than normal but 90g/L and above person thereof for slight; Lower, but be moderate at 60g/L and above person thereof; Or lower, but be severe at 30g/L and above person thereof; Be lower than 30g/L and above person thereof and be the extreme anemia.In addition, note except false anemia.As when existing gestation or liver cirrhosis etc. to make in the body water retention cause plasma volume to increase, even the whole body red blood cell volume is normal, but measured RBC number and hemoglobin concentration also can lower, and easily thinks anemia by mistake.Otherwise if when having obvious dehydration hyperamization slurry capacity to reduce, even anemia is arranged, measured erythrocyte and hemoglobin concentration may be normal.When judging anemia, these factors all should be noted.
Anemia is by pathogenic factor, and anemia can be divided into defective blood formation, losing blood property and hemolytic three major types.
The Anemia performance relates to each tract of whole body.Should notice that onset is anxious slow, evolution and characteristic performance thereof.More anxious as the normal onset of acute aplastic anemia, carrying out property of anemia increases the weight of, the then normal onset of chronic aplastic anemia, iron deficiency anemia, chronic hemolytic anemia is slow, and the course of disease is long.Acute haemolysis onset is hurried, the shiver with cold hyperpyrexia, and muscular soreness can be accompanied color of soy sauce urine.Megaloblastic anemia often has stomatoglossitis and causalgia.Anemia with different have a liking for separate or acataposis and retrosternal pain arranged, should expect iron deficiency anemia.Anemia is more common in acute aplastic anemia, leukemia and malignant histocytosis etc. with hemorrhage and heating or infection.
The paathogenic factor of anemia is a lot, mainly contains following five big reasons:
One, losing blood is to account for to cause seventy percent of anemia, can be divided into accident trauma and lose blood greatly, and chronic disease has bleeding, and as pulmonary tuberculosis, gastric ulcer, hemorrhoid, hematuria etc., and operation, production etc. easily cause and lose blood.
Two, allowance of nutrients deficiency: in infancy stage, adolescence, pregnancy, age of sucking etc., relatively large nutrition is often supplied with in the somagenic need calibration, not so very easily causes anemia.
Three, nutritional disorder: drink for a long time, suffer from diarrhoea, go on a diet, particular about food, ingesting unbalanced also is the factor that causes anemia.
Four, disease: stomach excision, parasite, serious hepatopathy, wash kidney patient, cancer patient the anemia phenomenon is all arranged easily.
Five, congenital diseases: the not optimum anemia of the reproducibility of bone marrow hematogenesis underactivity reaches the hemolytic anemia that erythrocyte crumbles from body.
The traditional Chinese medical science thinks that anemia belongs to the category of " blood deficiency, asthenia ", and it mainly is due to the weakness of the spleen and stomach that this disease takes place.Chinese medicine thinks that the generation of QI and blood is precise and tiny from hydration.Taste are source of generating QI and blood.The strong then absorbing power of taste is strong, and QI and blood biochemistry is vigorous.The traditional Chinese medical science ought be used invigorating the spleen and benefiting QI, the method for qi and blood tonifying to the treatment of anemia.
The traditional Chinese medical science is thought, " all blood all belongs to the heart ", " middle Jiao extracting juice of being bullied, change and red be meaning blood ", " source of blood is kidney, vital essence abundance, hundred normal pulse are smooth ".This shows that the generation of blood derives from essence-QI from water and grain, the people absorbs water paddy nutrient substance, has absorbed the precise and tiny of food by middle Jiao (taste), by gasification, becomes ying-qi.Spleen gets heart-fire and declares helping of falling, and is converted into essence, body fluid, and the part of essence is stored in the kidney, and to treat the usefulness of biochemistry, another part gets helping of heart-fire and is converted into blood.Congenital essence gets the essence-QI from water and grain day after tomorrow in the kidney, absorbs the transpiration of life fire, is converted into marrow.Marrow gets that the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is burning hot ly to swash, and is divided into the seminal fluid of marrow, and seminal fluid is converted into blood for a surname of life fire steams again, and is defeated in body, thinks the usefulness of physiology.
Zang-Fu relationships such as the generation of blood and adjusting and the heart, liver,spleen,kidney are close, so traditional Chinese medical science meaning " heart master blood, blood stored in the liver, The spleen governs the blood ".And the giving full play to of these functions, the life fire that depends on kidney again is warm.Therefore, the heart, liver,spleen,kidney function are weak, all can cause blood deficiency.And the formation of blood deficiency is nothing more than internal and external factor.Exopathogen six climate exopathogens and warm intrusion body are dived and are irregularly gone out, and deeply change the machine of blood, cause fresh blood not have life, and this paathogenic factor and modern medicine said " bacterial infection, protozoon, toxin generation haemolysis are disease " are perfectly in harmony.On endogenous cause of ill, or forfeit one's integrity for seven emotions, or be improper diet, or form for losing blood, or be the natural endowment deficiency, or exaggerate for exhaustion due to sexual indulgence after being ill, or be the gestation imbalance, and cause that the machine of hemopoietic is obstructed, or the machine disorder of digestion, indigestion does not precise and tinyly become, and the disease of blood deficiency takes place.
Blood is tangible thing, and gas belongs to invisible usefulness.The operation of blood depends on gas, thus have " qi being the governor of blood, the capable then blood of gas is capable, blood being the material foundation of QI, blood to gas also to " theory.Blood is given birth to by gas, and gas also must have blood for depending on the effect of its biochemistry of competence exertion, motion.The two interdepends, and promotes mutually again, keeps relative equilibrium.If qi-blood disharmony, will cause a disease." interior warp " said: " excess of QI leading to insufficiency of blood hereat, the institute of blood and be the deficiency of vital energy." therefore, blood deficiency patient generally all has the deficiency of vital energy, the Chinese traditional treatment anemia is mainly started with the spleen invigorating stomach warming, replenishes QI and blood, changes the source of life.
The traditional Chinese medical science adopts this disease of decoction for the treatment of strengthening spleen, tonifying kidney, benefiting QI and nourishing blood.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of anemia.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of anemia, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Semen Nelumbinis 10-20 weight portion italian-jobi jen 25-30 weight portion Radix Ginseng 3-5 weight portion
Rhizoma Atractylodis Macrocephalae 5-15 weight portion Radix Glycyrrhizae 5-15 weight portion Radix Angelicae Sinensis 10-20 weight portion
Poria 15-20 weight portion Herba Leonuri 10-15 weight portion Rhizoma Chuanxiong 25-40 weight portion
Rhizoma dioscoreae 5-10 weight portion Semen Euryales 10-15 weight portion Radix Astragali 15-20 weight portion
Cortex Moutan 10-15 weight portion Radix Rehmanniae 20-30 weight portion Cortex Lycii 5-15 weight portion
Radix Scrophulariae 5-10 weight portion Radix Paeoniae Alba 20-40 weight portion Fructus Lycii 25-40 weight portion
Cornu Cervi Pantotrichum 5-10 weight portion
Effective ingredient is preferably made by weight by following raw materials according:
Semen Nelumbinis 16 weight portion italian-jobi jens 28 weight portion Radix Ginsengs 4 weight portions
The Rhizoma Atractylodis Macrocephalae 12 weight portion Radix Glycyrrhizaes 12 weight portion Radix Angelicae Sinensis 16 weight portions
Poria 18 weight portion Herba Leonuris 13 weight portion Rhizoma Chuanxiongs 33 weight portions
The Rhizoma dioscoreae 8 weight portion Semen Euryaless 13 weight portion Radixs Astragali 18 weight portions
The Cortex Moutan 13 weight portion Radix Rehmanniae 26 weight portion Cortex Lycii 11 weight portions
The Radix Scrophulariae 8 weight portion Radix Paeoniae Albas 33 weight portion Fructus Lyciis 33 weight portions
Cornu Cervi Pantotrichum 8 weight portions
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) Pulveratum Cornu Cervi Pantotrichum is broken into impalpable powder, and is standby;
(2) Semen Nelumbinis, Radix Glycyrrhizae, the Radix Rehmanniae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) italian-jobi jen, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Poria, Herba Leonuri, Rhizoma Chuanxiong, Rhizoma dioscoreae, Semen Euryales, the Radix Astragali, Cortex Moutan, Cortex Lycii, Radix Scrophulariae, the Radix Paeoniae Alba, Fructus Lycii, decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, makes granule, capsule and tablet with pharmaceutically acceptable carrier.
Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has the effect of strengthening spleen, tonifying kidney, benefiting QI and nourishing blood, is used for diseases such as caused by liver and kidney deficiency that anemia causes, lusterless complexion, dizziness and blurred vision, shortness of breath and palpitation, insomnia forgetfulness, numb limbs and tense tendons.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) Cornu Cervi Pantotrichum 8g is ground into impalpable powder, and is standby;
(2) Semen Nelumbinis 16g, Radix Glycyrrhizae 12g, Radix Rehmanniae 26g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) italian-jobi jen 28g, Radix Ginseng 4g, Rhizoma Atractylodis Macrocephalae 12g, Radix Angelicae Sinensis 16g, Poria 18g, Herba Leonuri 13g, Rhizoma Chuanxiong 33g, Rhizoma dioscoreae 8g, Semen Euryales 13g, Radix Astragali 18g, Cortex Moutan 13g, Cortex Lycii 11g, Radix Scrophulariae 8g, Radix Paeoniae Alba 33g, Fructus Lycii 33g, decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add dextrin 100g, lactose 80g, mixing, with 75% ethanol wet granulation promptly.
Embodiment 2: Chinese medicinal composition capsules agent of the present invention
(1) Cornu Cervi Pantotrichum 8g is ground into impalpable powder, and is standby;
(2) Semen Nelumbinis 16g, Radix Glycyrrhizae 12g, Radix Rehmanniae 26g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) italian-jobi jen 28g, Radix Ginseng 4g, Rhizoma Atractylodis Macrocephalae 12g, Radix Angelicae Sinensis 16g, Poria 18g, Herba Leonuri 13g, Rhizoma Chuanxiong 33g, Rhizoma dioscoreae 8g, Semen Euryales 13g, Radix Astragali 18g, Cortex Moutan 13g, Cortex Lycii 11g, Radix Scrophulariae 8g, Radix Paeoniae Alba 33g, Fructus Lycii 33g, decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add dextrin 70g, mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) Cornu Cervi Pantotrichum 8g is ground into impalpable powder, and is standby;
(2) Semen Nelumbinis 16g, Radix Glycyrrhizae 12g, Radix Rehmanniae 26g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) italian-jobi jen 28g, Radix Ginseng 4g, Rhizoma Atractylodis Macrocephalae 12g, Radix Angelicae Sinensis 16g, Poria 18g, Herba Leonuri 13g, Rhizoma Chuanxiong 33g, Rhizoma dioscoreae 8g, Semen Euryales 13g, Radix Astragali 18g, Cortex Moutan 13g, Cortex Lycii 11g, Radix Scrophulariae 8g, Radix Paeoniae Alba 33g, Fructus Lycii 33g, decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds starch 30g, microcrystalline Cellulose 10g and carboxymethylstach sodium 10g, with 70% ethanol wet granulation, tabletting, coating are promptly.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of anemia is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Semen Nelumbinis 10-20 weight portion italian-jobi jen 25-30 weight portion Radix Ginseng 3-5 weight portion
Rhizoma Atractylodis Macrocephalae 5-15 weight portion Radix Glycyrrhizae 5-15 weight portion Radix Angelicae Sinensis 10-20 weight portion
Poria 15-20 weight portion Herba Leonuri 10-15 weight portion Rhizoma Chuanxiong 25-40 weight portion
Rhizoma dioscoreae 5-10 weight portion Semen Euryales 10-15 weight portion Radix Astragali 15-20 weight portion
Cortex Moutan 10-15 weight portion Radix Rehmanniae 20-30 weight portion Cortex Lycii 5-15 weight portion
Radix Scrophulariae 5-10 weight portion Radix Paeoniae Alba 20-40 weight portion Fructus Lycii 25-40 weight portion
Cornu Cervi Pantotrichum 5-10 weight portion
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
Semen Nelumbinis 16 weight portion italian-jobi jens 28 weight portion Radix Ginsengs 4 weight portions
The Rhizoma Atractylodis Macrocephalae 12 weight portion Radix Glycyrrhizaes 12 weight portion Radix Angelicae Sinensis 16 weight portions
Poria 18 weight portion Herba Leonuris 13 weight portion Rhizoma Chuanxiongs 33 weight portions
The Rhizoma dioscoreae 8 weight portion Semen Euryaless 13 weight portion Radixs Astragali 18 weight portions
The Cortex Moutan 13 weight portion Radix Rehmanniae 26 weight portion Cortex Lycii 11 weight portions
The Radix Scrophulariae 8 weight portion Radix Paeoniae Albas 33 weight portion Fructus Lyciis 33 weight portions
Cornu Cervi Pantotrichum 8 weight portions
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) Pulveratum Cornu Cervi Pantotrichum is broken into impalpable powder, and is standby;
(2) Semen Nelumbinis, Radix Glycyrrhizae, the Radix Rehmanniae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) italian-jobi jen, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Poria, Herba Leonuri, Rhizoma Chuanxiong, Rhizoma dioscoreae, Semen Euryales, the Radix Astragali, Cortex Moutan, Cortex Lycii, Radix Scrophulariae, the Radix Paeoniae Alba, Fructus Lycii decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078589A (en) * | 2010-12-27 | 2011-06-01 | 谷建松 | Marrow-replenishing blood-nourishing pill |
| CN102727664A (en) * | 2012-05-31 | 2012-10-17 | 固镇县中医院 | Chinese herbal preparation for treating thrombocytopenia |
| CN103393823A (en) * | 2013-07-19 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing Chinese angelica and preparation method thereof |
| CN103505714A (en) * | 2013-10-11 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating palpitation with syndrome of heart-blood insufficiency |
| CN103784853A (en) * | 2014-03-08 | 2014-05-14 | 林江 | Chinese herbal preparation for treating anemia and preparing method |
| CN104256006A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Yin-enriching, beautifying, ageing-resisting and life-nourishing tea and preparation method thereof |
| CN104524223A (en) * | 2015-01-21 | 2015-04-22 | 张成杰 | Pharmaceutical composition for treating hypotension |
| CN105362804A (en) * | 2015-11-30 | 2016-03-02 | 四川聚豪生物科技有限公司 | Traditional Chinese medicine composition for treating mild anemia and method for preparing traditional Chinese medicine composition |
| CN107874251A (en) * | 2017-11-14 | 2018-04-06 | 广东健来福云健康科技股份有限公司 | A kind of eight delicacies probiotic composition with strengthening the spleen and stomach benefit function of intestinal canal |
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- 2008-03-06 CN CN200810101444A patent/CN101524490A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078589A (en) * | 2010-12-27 | 2011-06-01 | 谷建松 | Marrow-replenishing blood-nourishing pill |
| CN102727664A (en) * | 2012-05-31 | 2012-10-17 | 固镇县中医院 | Chinese herbal preparation for treating thrombocytopenia |
| CN102727664B (en) * | 2012-05-31 | 2014-05-14 | 固镇县中医院 | Traditional Chinese medicine preparation for treating thrombocytopenia |
| CN103393823A (en) * | 2013-07-19 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing Chinese angelica and preparation method thereof |
| CN103505714A (en) * | 2013-10-11 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating palpitation with syndrome of heart-blood insufficiency |
| CN103784853A (en) * | 2014-03-08 | 2014-05-14 | 林江 | Chinese herbal preparation for treating anemia and preparing method |
| CN103784853B (en) * | 2014-03-08 | 2016-03-23 | 李晓华 | A kind of Chinese medicine preparation and preparation method for the treatment of anemia |
| CN104256006A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Yin-enriching, beautifying, ageing-resisting and life-nourishing tea and preparation method thereof |
| CN104524223A (en) * | 2015-01-21 | 2015-04-22 | 张成杰 | Pharmaceutical composition for treating hypotension |
| CN105362804A (en) * | 2015-11-30 | 2016-03-02 | 四川聚豪生物科技有限公司 | Traditional Chinese medicine composition for treating mild anemia and method for preparing traditional Chinese medicine composition |
| CN107874251A (en) * | 2017-11-14 | 2018-04-06 | 广东健来福云健康科技股份有限公司 | A kind of eight delicacies probiotic composition with strengthening the spleen and stomach benefit function of intestinal canal |
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Open date: 20090909 |