CN101514211A - Preparation method for boron-10 neutral complex - Google Patents
Preparation method for boron-10 neutral complex Download PDFInfo
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- CN101514211A CN101514211A CNA2009100109677A CN200910010967A CN101514211A CN 101514211 A CN101514211 A CN 101514211A CN A2009100109677 A CNA2009100109677 A CN A2009100109677A CN 200910010967 A CN200910010967 A CN 200910010967A CN 101514211 A CN101514211 A CN 101514211A
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- sodium hydroxide
- boron
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Abstract
The invention discloses a preparation method for boron-10 neutral complex, which has simple operation, inexpensive cost and one-time regulated pH value and which is implemented according to the following steps of: putting boric acid solution in a vessel, adding a neutral indicator of which the volume is 0.1-0.2% of that of the boric acid solution, then adding a polyhydroxy organic compound which is equal to the boric acid in mol, uniformly mixing, sealing off and setting aside the vessel for 20-30 minutes, titrating diluted sodium hydroxide solution into the vessel until the solution is suddenly changed into reddish-purple, and measuring the volume of the used diluted sodium hydroxide solution; putting boron-10 acidic solution in the vessel, adding the polyhydroxy organic compound which is equal to the boron-10 in mol, uniformly mixing, sealing off and setting aside the vessel for 20-30 minutes, and adding the diluted sodium hydroxide solution having the same concentration as the solution in the step a, for uniformly mixing, wherein, the volume ratio of the added diluted sodium hydroxide solution to the boron-10 acidic solution is identical to the volume ratio of the diluted sodium hydroxide solution used in the step a to the boric acid solution.
Description
Technical field:
The present invention relates to the preparation method of a kind of boron-10 title complex, especially a kind of simple to operate, with low cost, pH value is adjusted the preparation method of the disposable boron that puts in place-10 neutral compound.
Background technology:
The boron of occurring in nature mainly by
11B and
10Two kinds of isotopics of B, wherein
10B is in the special effect of fields such as nuclear defence, nuclear industry performance.
10B accounts for 19% of its total amount, is will by various extraction processes
10B and
11B separates, and then will
10B extracts, owing to be subjected to the separation processes condition restriction, the isotopic output of boron-10 is few, cost an arm and a leg.At present, the existing relevant report that in theory the isotopic neutral compound of boron-10 is applied to chemical catalysis reaction field and medical organic synthesis and nuclear medicine aspect, especially it has unique avidity for cancer cells, therefore how to be applied to treatment for cancer, more to have caused concern and extensive studies that people are close.Require the pH value of applied boron-10 neutral compound should approach 8 in theory, this title complex should be able to be water-soluble and be water white in water, selected Synergist S-421 95 can be selected as required, but further application can not bring any influence to title complex, require the adjustment of pH value must disposable putting in place simultaneously, can not do the secondary adjustment with acid or alkali, and regulate the pH value and can not bring other detrimental impurity into.Harsh requirement causes the isotopic neutral compound making of boron-10 difficulty, as making failure, will bring bigger financial loss, does not therefore also have any report about boron-10 neutral compound preparation method up to now.
Summary of the invention:
The present invention is in order to solve the existing the problems referred to above of prior art, and a kind of simple to operate, with low cost, preparation method that the pH value is adjusted the disposable boron that puts in place-10 neutral compound is provided.
Technical solution of the present invention is: the preparation method of a kind of boron-10 neutral compound is characterized in that carrying out as follows:
A. get boric acid solution in container, adding volume is the neutral indicator of boric acid solution 0.1～0.2%, add with institute's boronic acid containing equimolar poly-hydroxy class organic compound again and mix, airtight leaving standstill 20～30 minutes, be titrated in the container to solution with diluted sodium hydroxide solution and sport red-violet colour, the First Astronautic Research Institute for Measurement and Test is with the volume of diluted sodium hydroxide solution;
B. get boron-10 acid solution in container, adding and institute's boracic-10 equimolar poly-hydroxy class organic compound also mix, airtight leaving standstill 20～30 minutes, add the diluted sodium hydroxide solution identical with a step concentration and mix, the volume ratio of the diluted sodium hydroxide solution that is added and boron-10 acid solution is identical with the volume ratio of used diluted sodium hydroxide solution of a step and boric acid solution.
The present invention is with cheap boric acid solution, neutral developer and poly-hydroxy class organic compound are raw material, determine the consumption of diluted sodium hydroxide solution with the method for diluted sodium hydroxide solution titration colour developing, and then with boron-10 acid solution, the diluted sodium hydroxide solution of poly-hydroxy class organic compound and standard consumption is mixed with boron-10 neutral compound, simple to operate, with low cost, the pH value is adjusted disposable putting in place, avoided regulating pH value with acidometer and measured hysteresis quality because of it and produce problem greater than 0.5 pH value deviation, prepared boron-10 neutral compound meets theoretical requirement fully.
Embodiment:
A. the solution of getting 100 milliliters of boronic acid containing 300 mg/litre earlier is in tool plug triangular flask, add 0.1～0.2 milliliter of neutral indicator (as the blue system of phenol red-careless phenol etc.), add and the equimolar poly-hydroxy class of boric acid organic compound again, as glycerine, glucose, Nulomoline, N.F,USP MANNITOL, inosine etc., shake up, build bottle stopper and be in air-tight state, left standstill 20～30 minutes, this moment, solution was yellow, sport red-violet colour with the one-level reagent sodium hydroxide solution titration of about 0.05M solution to the bottle then, the First Astronautic Research Institute for Measurement and Test is 30 milliliters with sodium hydroxide volume number;
B. get 1000 milliliters of boron-10 acid solutions in container, add and the equimolar poly-hydroxy class of institute's boracic-10 organic compound, as glycerine, glucose, Nulomoline, N.F,USP MANNITOL, inosine etc., shake up, build bottle stopper and be in air-tight state, left standstill 20～30 minutes, add about 0.05M one-level reagent sodium hydroxide solution (with the used sodium hydroxide solution of a step be same reagent) mix, the sodium hydroxide solution that is added should be with the volume ratio of used sodium hydroxide solution of a step and boric acid solution identical (30: 100), so the add-on of sodium hydroxide solution is 300 milliliters with the volume ratio of boron-10 acid solution.
Gained solution is boron-10 neutral compound, is 8.01 through surveying its pH value, and title complex can be water-soluble and be water white in water; Used Synergist S-421 95 is a poly-hydroxy class organic compound, and title complex is further used without any influence; Because what the diluted sodium hydroxide solution that is added was selected for use is one-level reagent, so do not contain harmful impurity.
Can enlarge the output of boron-10 neutral compound as required,, enlarge multiple at every turn and preferably get 10 times and be advisable in order to reduce error.
Claims (1)
1. the preparation method of boron-10 neutral compound is characterized in that carrying out as follows:
A. get boric acid solution in container, adding volume is the neutral indicator of boric acid solution 0.1～0.2%, add with institute's boronic acid containing equimolar poly-hydroxy class organic compound again and mix, airtight leaving standstill 20～30 minutes, be titrated in the container to solution with diluted sodium hydroxide solution and sport red-violet colour, the First Astronautic Research Institute for Measurement and Test is with the volume of diluted sodium hydroxide solution;
B. get boron-10 acid solution in container, adding and institute's boracic-10 equimolar poly-hydroxy class organic compound also mix, airtight leaving standstill 20～30 minutes, add the diluted sodium hydroxide solution identical with a step concentration and mix, the volume ratio of the diluted sodium hydroxide solution that is added and boron-10 acid solution is identical with the volume ratio of used diluted sodium hydroxide solution of a step and boric acid solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100109677A CN101514211A (en) | 2009-04-02 | 2009-04-02 | Preparation method for boron-10 neutral complex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100109677A CN101514211A (en) | 2009-04-02 | 2009-04-02 | Preparation method for boron-10 neutral complex |
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| Publication Number | Publication Date |
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| CN101514211A true CN101514211A (en) | 2009-08-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009100109677A Pending CN101514211A (en) | 2009-04-02 | 2009-04-02 | Preparation method for boron-10 neutral complex |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017184431A1 (en) * | 2016-04-19 | 2017-10-26 | Hexion Inc. | Incorporation of boron complex into resin |
-
2009
- 2009-04-02 CN CNA2009100109677A patent/CN101514211A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017184431A1 (en) * | 2016-04-19 | 2017-10-26 | Hexion Inc. | Incorporation of boron complex into resin |
| CN109247019A (en) * | 2016-04-19 | 2019-01-18 | 瀚森公司 | Introducing of the boron complex to resin |
| US11618838B2 (en) | 2016-04-19 | 2023-04-04 | Hexion Inc. | Incorporation of boron complex into resin |
| CN109247019B (en) * | 2016-04-19 | 2024-01-02 | 瀚森公司 | Introduction of boron complexes into resins |
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Application publication date: 20090826 |