CN101496795B - Technique for preparing biodegradable composite controlled release membrane of medicament - Google Patents
Technique for preparing biodegradable composite controlled release membrane of medicament Download PDFInfo
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- CN101496795B CN101496795B CN2009100105394A CN200910010539A CN101496795B CN 101496795 B CN101496795 B CN 101496795B CN 2009100105394 A CN2009100105394 A CN 2009100105394A CN 200910010539 A CN200910010539 A CN 200910010539A CN 101496795 B CN101496795 B CN 101496795B
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Abstract
The present invention provides a biodegradation compound medicine controlled release film and a process for preparing the same. The film is designed aiming at solving the technical problems that the prior dressing film has relatively poor mechanical strength to different extents, is hard to keep the wound surface wet, has unobvious treating effect on the wound surface, high price and certain antigenicity, and is uneasy to apply in wide range, and the like. The release film is prepared from the following components in percentage by weight: 0 to 35 percent of chitosan, 50 to 100 percent of PLA or PLGA and 0.1 to 25 percent of anti-inflammation and sterilization medicines. The preparation process is realized by the following steps that: firstly, the chitosan and the PLA or PLGA are dissolved in a cosolvent, namely trifluoroacetic acid and prepared into an even solution, and the even solution is added with medicine components, subjected to ultrasonic oscillation to fully dissolve and disperse the medicines, and then subjected to flow casting and film forming. The film has the characteristics of good film forming property, medium mechanical strength, good blood stopping effect, medium degrading speed, the maintaining of the wetness on the wound surface, obvious anti-inflammation and sterilization effects, simple preparation process and low cost, and can be widely used for the treatment of the wound surfaces of burning and hurting and the recovering treatment of operation wound.
Description
Technical field:
The present invention relates to a kind of preparation technology of controlled release membrane of medicament, relate in particular to a kind of preparation technology of Biodegradable composite controlled release membrane of medicament.Can be widely used in burning, the Wound treating of wound and resuming treatment of postoperative wound.
Background technology:
Skin is the organ of human body maximum, if skin is subjected to large tracts of land damage, then can cause many parts even general problem, as metabolism aggravation, moisture and protein excessively scatter and disappear, immune system disorder etc., the serious entail dangers to life of going back.If wound surface covers suitable dressing, can effectively reduce the metabolic order of severity of patient's body superelevation, ease the pain, prevent bacterial infection, quicken wound healing.Therefore, people extensively explore the Wound dressing that can be used as skin barrier in recent years.Chinese patent [CN 1395968] discloses a kind of biological fluid dressing chitosan membrane and preparation method thereof.It is characterized in that through acidolysis, add adjuvants such as gelatin, glycerol, neutralize and filter through sodium bicarbonate again.But this fluid dressing membrane mechanical strength is relatively poor, is not easy to keep wound surface moistening.Chinese patent [CN 1554448] discloses the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol, is formulated by chitosan, gelatin, polyvinyl alcohol, glycerol.This dressing has hydrophilic, film property, tractive and haemostatic effect preferably, but wound surface is not had the obvious treatment effect.Chinese patent [CN 1380109] discloses a kind of chitosan, collagen and sodium alginate compounded spongy biological dressing and preparation technology thereof.This dressing good biocompatibility, adhesiveness is strong, has the active function and the anastalsis that promote wound healing.But its used type i collagen price is comparatively expensive, and has certain antigenicity, is unfavorable for widespread adoption.
Summary of the invention:
The present invention for solve existing dressing membrane in various degree exist mechanical strength relatively poor, be not easy to keep wound surface moistening, not obvious and price is comparatively expensive to the Wound treating effect, and has certain antigenicity, be unfavorable for technical problems such as widespread adoption, a kind of preparation technology of Biodegradable composite controlled release membrane of medicament is provided, and this release film is prepared by following percentage by weight: chitosan 0%-35%, PLA or PLGA 49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%.
Its preparation technology realizes by following step by said ratio:
Earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, are prepared into homogeneous solution, add ingredient then,, make medicine fully dissolve dispersion, casting film-forming again through sonic oscillation.
Characteristics of the present invention and beneficial effect: medicine sustained release composite membrane of the present invention has good film-forming property, mechanical strength is moderate, haemostatic effect good, degradation speed is moderate and can keep wound surface moistening, tangible anti-inflammation and sterilization effect arranged, and preparation technology is simple, cost is low, can be widely used in the treatment of burning, wound and wound surface and resuming treatment of postoperative wound.
The biodegradable blend film of chitosan and PLA or PLGA has excellent biological compatibility, degradability, toughness and breathability, has the protection wound surface, attracts effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.Improved its anti-inflammatory and blend film and antibacterials are combined with each other.
Description of drawings:
Fig. 1. contain the optical microscope photograph that 15% ring third kills this controlled release membrane of medicament of star
Fig. 2. contain the release profiles that 15% ring third kills this controlled release membrane of medicament of star
Fig. 3. contain the optical microscope photograph of this controlled release membrane of medicament of 8% sulfadiazine
Fig. 4. contain the release profiles of this controlled release membrane of medicament of 8% sulfadiazine
The specific embodiment:
The preparation technology of Biodegradable composite controlled release membrane of medicament, this release film is prepared by following percentage by weight: chitosan 0%-35%, PLA or PLGA 49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%.
Its preparation technology realizes by following step:
Earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, are prepared into homogeneous solution, add ingredient then,, make medicine fully dissolve dispersion, casting film-forming again through sonic oscillation.
Described chitosan is a medicated chitin, and molecular weight is below 10000, and deacetylation is 75%～95%.
Described PLA or PLGA, molecular weight be 20,000-500,000.
Described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill the star medicine.
Chitosan is that occurring in nature is only second to cellulosic second largest biological polyoses, also is the alkaline polysaccharide of the unique a large amount of existence of occurring in nature simultaneously.Biologically active of chitosan own and anastalsis can stop formation, the hypertrophy of connective tissue cell and the synthesizing of collagen protein of fibrin element.Poly-'alpha '-hydroxy acids such as PLA or PLGA is the biodegradable polymer of synthetic, have advantages such as good biocompatibility, mechanical strength be good, especially PLA by U.S. food and drug administration regard as can be applicable to clinical, as as operation suture thread and embedded material etc., and can go out good intermingling material with Preparation of Chitosan.Poly-'alpha '-hydroxy acids excellent mechanical intensity such as PLA or PLGA can remedy the defective of chitosan bad mechanical strength just.The biodegradable blend film of chitosan and PLA or PLGA has excellent biological compatibility, degradability, toughness and breathability, has the protection wound surface, attracts effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.Improved its anti-inflammatory and blend film and antibacterials are combined with each other.
Embodiment 1. is dissolved in medicated chitin 35% (molecular weight is 10,000) and PLA 50% (molecular weight is 100,000) in the trifluoroacetic acid, adds anti-inflammatory drug ring third then and kills star 15%, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.Referring to Fig. 1 is the optical microscope photograph of this film.Referring to Fig. 2 is the sustained release curve of this controlled release membrane of medicament in 37 ℃ of phosphate buffers.
Embodiment 2. is dissolved in medicated chitin 25% (molecular weight is 3000) and PLGA 65% (molecular weight is 80,000) in the trifluoroacetic acid, adds anti-inflammatory drug ring third then and kills star 10%, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.
Embodiment 3. is dissolved in medicated chitin 20% (molecular weight is 8000) and PLA 72% (molecular weight is 150,000) in the trifluoroacetic acid, adds anti-inflammatory drug sulfadiazine 8% then, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.Referring to Fig. 3 is the optical microscope photograph of this film.Referring to Fig. 4 is the release profiles of this controlled release membrane of medicament in 37 ℃ of phosphate buffers.
Embodiment 4. is dissolved in medicated chitin 10% (molecular weight is 3000) and PLGA 70% (molecular weight is 50,000) in the trifluoroacetic acid, adds anti-inflammatory drug sulfadiazine 20% then, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.
Embodiment 5. is dissolved in medicated chitin 0% (molecular weight is 0) and PLA 99.9% (molecular weight is 40,000) in the trifluoroacetic acid, adds anti-inflammatory drug ring third then and kills star 0.1%, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.
Embodiment 6. is dissolved in medicated chitin 50% (molecular weight is 5000) and PLGA 49.9% (molecular weight is 200,000) in the trifluoroacetic acid, adds anti-inflammatory drug promise fluorine then and kills star 0.1%, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.
Embodiment 7. is dissolved in medicated chitin 30% (molecular weight is 6000) and PLA 45% (molecular weight is 300,000) in the trifluoroacetic acid, adds anti-inflammatory drug silver sulfadiazine 25% then, and sonic oscillation makes medicine fully dissolve dispersion, casting film-forming again.
The deacetylation of the medicated chitin described in the foregoing description 1-7 is 75%～95%.
Claims (8)
1. the preparation technology of Biodegradable composite controlled release membrane of medicament, it is characterized in that: release film is prepared by following percentage by weight: chitosan 0%-35%, PLA or PLGA49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%;
Its preparation technology realizes by following step: earlier chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, are prepared into homogeneous solution, add the anti-inflammation and sterilization ingredient then, through sonic oscillation, make medicine fully dissolve dispersion, casting film-forming again.
2. the preparation technology of Biodegradable composite controlled release membrane of medicament according to claim 1 is characterized in that: described release film is by the percentage by weight preparation of chitosan 35%, PLA or PLGA 50% and anti-inflammation and sterilization medicine 15%.
3. the preparation technology of Biodegradable composite controlled release membrane of medicament according to claim 1 is characterized in that: described release film is by the percentage by weight preparation of chitosan 25%, PLA or PLGA 65% and anti-inflammation and sterilization medicine 10%.
4. the preparation technology of Biodegradable composite controlled release membrane of medicament according to claim 1 is characterized in that: described release film is by the percentage by weight preparation of chitosan 20%, PLA or PLGA 72% and anti-inflammation and sterilization medicine 8%.
5. the preparation technology of Biodegradable composite controlled release membrane of medicament according to claim 1 is characterized in that: described release film is by the percentage by weight preparation of chitosan 10%, PLA or PLGA 70% and anti-inflammation and sterilization medicine 20%.
6. according to the preparation technology of any one Biodegradable composite controlled release membrane of medicament described in the claim 1-5, it is characterized in that: described chitosan is a medicated chitin, and molecular weight is below 10000, and deacetylation is 75%～95%.
7. according to the preparation technology of any one Biodegradable composite controlled release membrane of medicament described in the claim 1-5, it is characterized in that: described PLA or PLGA, molecular weight be 20,000-500,000.
8. according to the preparation technology of any one Biodegradable composite controlled release membrane of medicament described in the claim 1-5, it is characterized in that: described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill star.
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| CN2009100105394A CN101496795B (en) | 2009-03-03 | 2009-03-03 | Technique for preparing biodegradable composite controlled release membrane of medicament |
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| CN103418023B (en) * | 2013-07-29 | 2014-09-03 | 大连医科大学 | Multilayer composite hemostatic material and preparation method thereof |
| CN103434229B (en) * | 2013-08-22 | 2015-09-16 | 华南理工大学 | A kind of multi-layer oriented controlled release antibiotic film and preparation method thereof and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857236A (en) * | 2006-03-08 | 2006-11-08 | 曾敬 | Compound medicine release controlling film of chitosan, sodium alginate and gelatin and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1857236A (en) * | 2006-03-08 | 2006-11-08 | 曾敬 | Compound medicine release controlling film of chitosan, sodium alginate and gelatin and its preparing process |
Non-Patent Citations (4)
| Title |
|---|
| Manisara Peesan et al.Preparation and characterization of hexanoyl chitosan/polylactide blend films.Carbohydrate Polymers.2005,60343-350. * |
| Nugraha E. Suyatma et al.Mechanical and Barrier Properties of Biodegradable Films Made from Chitosan and Poly (Lactic Acid) Blends.Journal of Polymers and the Environment.2004,12(1),1-6. * |
| P. Perugini et al.Periodontal delivery of ipriflavone: new chitosan/PLGA film delivery system for a lipophilic drug.International Journal of Pharmaceutics.2003,1-9. * |
| Shaobing Zhou et al.In vitro degradation and release profiles for Poly-dl-lactide film containing paracetamol.J Mater Sci: Mater Med.2007,(18),1623-1626. * |
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