CN101491605A - Combination with blood sugar reducing function and preparation method thereof - Google Patents
Combination with blood sugar reducing function and preparation method thereof Download PDFInfo
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- CN101491605A CN101491605A CNA2008100567045A CN200810056704A CN101491605A CN 101491605 A CN101491605 A CN 101491605A CN A2008100567045 A CNA2008100567045 A CN A2008100567045A CN 200810056704 A CN200810056704 A CN 200810056704A CN 101491605 A CN101491605 A CN 101491605A
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- folium
- fructus momordicae
- momordicae charantiae
- extract
- psidii guajavae
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Abstract
The invention discloses a composition with the function of reducing blood sugar and a preparation method thereof. The composition is prepared from balsam pear, guava leaf and folium eriobotryae according to certain weight proportion. The composition can be prepared into any common preparation formulation. The composition of the invention has the efficacy of reducing blood sugar, and can be used for treating diabetes.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, belong to medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective cause of disease pool treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of compositions with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Cover melon 10-20 part, Folium Psidii Guajavae 1-10 part, Folium Eriobotryae 6-12 part with mat.
Be preferably:
15 parts in Fructus Momordicae charantiae, 3 parts of Folium Psidii Guajavae, 9 parts of Folium Eriobotryaes.
The preparation method of the present composition is as follows:
With Fructus Momordicae charantiae, Folium Psidii Guajavae, Folium Eriobotryae adds water or different concentration ethanol is extracted, filter, concentrate, dry, pulverize, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
The preferred for preparation method of the present composition is as follows:
With Fructus Momordicae charantiae with 70 ℃ of reflux, extract, of 10 times of amounts and 8 times amount 60% ethanol 2 times, each 3 hours, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, Fructus Momordicae charantiae extract; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With the Folium Eriobotryae water extraction, filter, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract; With Fructus Momordicae charantiae extract, Folium Psidii Guajavae extract, the Folium Eriobotryae fermented product mix homogeneously, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
Drug mechanism of the present invention is as follows:
Fructus Momordicae charantiae: the heat clearing away heart-fire of dispelling, detoxifcation makes eye bright, and the QI invigorating benefit is smart, quenches the thirst and relieves summer heat, and controls carbuncle.Fructus Momordicae charantiae contains nutritional labelings such as serotonine and glutamic acid, alanine, proline, y-aminobutyric acid, citrulline, galacturonic acid, pectin, candy, trace fat, protein, calcium, phosphorus, ferrum, carotene, vitamin B1, vitamin B2, vitamin C.Modern pharmacological research shows, Fructus Momordicae charantiae not only can obviously reduce blood sugar level after the fasting, but also can obviously reduce the level of cholesterol and triglyceride in the liver.Fructus Momordicae charantiae extract and blood sugar lowering medicine results of comparative experiment commonly used shows, the every kg body weight of drug-induced diabetes rat gives the Fructus Momordicae charantiae extract of 500 milligrams of dosage, can make 1 hour after the meal hemospermia level reduce 10%-15%, effect is equivalent to give the 25%-30% of same agent scape tolbutamide hypoglycemic effect, perhaps is equivalent to whenever do the gram body weight and gives 40% of 100 milligrams of tolbutamide hypoglycemic effects.With metformin comparison blood sugar decreasing effect the time, find, metformin makes 1 hour after the meal, 2 hours, 3.5 hours blood sugar level of diabetes model rat all reduce 40%-50%, although the Fructus Momordicae charantiae extract hypoglycemic effect is lower than metformin, also can make 3.5 hours after the meal blood glucose significantly reduce by 26%.In addition, the cohort study shows that Succus Momordicae charantiae can make 73% diabetic glucose tolerance raising.As seen, Fructus Momordicae charantiae has good hypoglycemic effect as natural food.
Folium Psidii Guajavae: sweet, puckery, flat.Function: astringing to arrest diarrhea, anti-inflammation hemostasia.Leaf, really: acute and chronic enteritis, dysentery, infantile dyspepsia; Bright leaf: traumatic injury is controlled in external, traumatic hemorrhage, ecthyma disunion of a specified duration.Recent study finds that Fructus psidii guajavae immaturus has good blood sugar lowering, effect for reducing fat, and Folium Psidii Guajavae is to have the sensitivity that improves Insulin receptor INSR, thereby has the effect of blood sugar lowering.It (is the B cell of alloxan damage pancreas islets of langerhans that this experiment is made diabetes model with the tail vein injection alloxan, cause insulin secretion to reduce, blood sugar increasing), different extract for treating with Folium Psidii Guajavae, the result shows that the treatment group has the obvious functions of blood sugar effect than model control group, and ethanol extract treatment group acts on the most obvious in three groups of treatment groups, thereby verified that not only Folium Psidii Guajavae has hypoglycemic activity very doughtily, and the foundation of science is provided for the exploitation of its effective ingredient.
Folium Eriobotryae: the Folium Eriobotryae sweet in the mouth, cool in nature, go into lung, stomach warp.The lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm.Confirming by zoopery, is that the Folium Eriobotryae tea set that raw material is made has blood sugar lowering and the effect that suppresses hypertension with the Folium Eriobotryae.With the feedstuff that is mixed with Folium Eriobotryae tea water extract and normal diet respectively feeding suffer from diabetes and hypertensive experimental mouse.Contrast and experiment shows that the edible diabetic mice average blood sugar value of Folium Eriobotryae tea component feedstuff that contains is than similar low about 19% of edible general feeds; And suffer from hypertensive experimental mouse continuous 7 weeks edible contain the feedstuff of Folium Eriobotryae tea component after, blood pressure about 20 millimetress of mercury that on average descended.In addition, the circumrenal interior fat of experimental mouse of picked-up Folium Eriobotryae tea component reduces, and intravital neutral fat has also reduced about 54%.
In the present composition, cover melon with mat as the food of bitterness is arranged, what contain the usual fewer contact of diabetes patient but has an in demand beneficial element; Folium Psidii Guajavae has the effect of antiinflammatory, can prevent and treat diabetic complication; Folium Eriobotryae has the effect of lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm, can eliminate the common agitation of diabetes patient, thirsty phenomenon.Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has the dispel effect of heart-fire, antiinflammatory, lung heat clearing stomach function regulating of heat clearing away.Can be used for prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of compositions of the present invention by following experiment.
1 materials and methods
1.1 experiment material:
Experimental subject: 40 of Wistar rats, male and female half and half, body weight 160 ± 20g.
Experimental drug: present composition extract, alloxan, glucose oxidase enzyme reagent kit.
Experiment equipment: 4 of spectrophotometer standard cuvettes, one on rat oral gavage pin, corresponding No. 4, No. 5 syringe needles of 5ml syringe, test tube, dropper, pipet, scalpel.
1.2 experimental technique:
Modelling: with getting 30 rats (male and female half and half), by 250mg/kg lumbar injection alloxan (being dissolved in aseptic injection water).2 survey blood glucose before and after modeling are defined as whole modelings successes.
The experiment grouping: modeling success rat is divided into three groups (male and female half and half) at random, and remaining rat is one group:
First group: normal blank group; Every day normal diet.
Second group: not administration of Cheng Mo group; Every day, normal saline was irritated stomach, normal diet.
The 3rd group: become mould low dosage administration group; Press the 100mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
The 4th group: become mould high dose administration group; Press the 200mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
1.3 experimental index: laboratory animal tail point is got blood, surveys concentration of glucose in the blood.
1.4 date processing: (x ± s) expression, relatively check with t in the group by data with means standard deviation for each index.
2 results: see Table 1
The statistical value of each experimental group of table 1
Compare * P＜0.05 with matched group, * * P＜0.01
The result shows, low dose therapy group of the present invention compares with matched group that there were significant differences (* P＜0.05), high-dose therapy group of the present invention is compared the difference (* * P＜0.01) that highly significant is arranged with matched group, illustrate that the present composition has clear and definite hypoglycemic effect.
The specific embodiment
Embodiment 1:
The preparation of the capsule of the present composition
A) take by weighing Fructus Momordicae charantiae 15kg, Folium Psidii Guajavae 3kg, Folium Eriobotryae 9kg;
B) with Fructus Momordicae charantiae with 70 ℃ of reflux, extract, of 10 times of amounts and 8 times amount 60% ethanol 2 times, each 3 hours, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, Fructus Momordicae charantiae extract; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With the Folium Eriobotryae water extraction, filter, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) with said extracted thing mix homogeneously, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of the present composition
A) take by weighing Fructus Momordicae charantiae 10kg, Folium Psidii Guajavae 1kg, Folium Eriobotryae 6kg;
B) Fructus Momordicae charantiae, Folium Psidii Guajavae, Folium Eriobotryae are measured with 10 times and 8 times of amount 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered, concentrating under reduced pressure, and drying is pulverized;
C) add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of the present composition
A) take by weighing Fructus Momordicae charantiae 20kg, Folium Psidii Guajavae 10kg, Folium Eriobotryae 12kg;
B) will cover melon with mat with 70 ℃ of reflux, extract, of 10 times of amounts and 8 times amount 70% ethanol 2 times, each 1 hour, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, Fructus Momordicae charantiae extract; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With the Folium Eriobotryae water extraction, filter, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) with said extracted thing mix homogeneously, be ground into powder, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 4:
The preparation of the tablet of the present composition
A) take by weighing Fructus Momordicae charantiae 15kg, Folium Psidii Guajavae 3kg, Folium Eriobotryae 9kg;
B) Fructus Momordicae charantiae, Folium Psidii Guajavae, Folium Eriobotryae are extracted 2 times with 10 times of amounts and 8 times of water gagings, each 3 hours, filter, concentrating under reduced pressure, drying is pulverized;
C) with said extracted thing mix homogeneously, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 5:
The preparation of the tablet of the present composition
A) take by weighing Fructus Momordicae charantiae 20kg, Folium Psidii Guajavae 3kg, Folium Eriobotryae 15kg;
B) with Fructus Momordicae charantiae with 70 ℃ of reflux, extract, of 10 times of amounts and 8 times amount 60% ethanol 2 times, each 3 hours, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, Fructus Momordicae charantiae extract; Folium Psidii Guajavae, Folium Eriobotryae are extracted with 10 times of amounts and 8 times of water gagings, and each 1 hour, merge extractive liquid, filtered, concentrating under reduced pressure, and drying is pulverized;
C) with said extracted thing mix homogeneously, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 6:
The preparation of the effervescent tablet of the present composition
A) take by weighing Fructus Momordicae charantiae 20kg, Folium Psidii Guajavae 5kg, Folium Eriobotryae 10kg;
B) with Fructus Momordicae charantiae, Folium Psidii Guajavae, Folium Eriobotryae with 10 times of amounts and 70 ℃ of reflux, extract, of 8 times of amount 60% ethanol 2 times, each 3 hours, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30, drying under reduced pressure down for 60 ℃;
C) with said extracted thing mix homogeneously, be ground into powder, mix homogeneously adds tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulates with dehydrated alcohol, and drying adds the lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of compositions with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: Fructus Momordicae charantiae 10-20 part, Folium Psidii Guajavae 1-10 part, Folium Eriobotryae 6-12 part.
According to the compositions of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 15 parts in Fructus Momordicae charantiae, 3 parts of Folium Psidii Guajavae, 9 parts of Folium Eriobotryaes.
3, claim 1 or 2 described preparation of compositions methods is characterized in that this method is: Fructus Momordicae charantiae, Folium Psidii Guajavae, Folium Eriobotryae are added water or different concentration ethanol extraction, filter, concentrate, drying is pulverized, and is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, preparation of compositions method according to claim 3, it is characterized in that, it comprises the following steps: Fructus Momordicae charantiae with 70 ℃ of reflux, extract, of 10 times of amounts and 8 times amount 60% ethanol 2 times, each 3 hours, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure gets Fructus Momordicae charantiae extract; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With the Folium Eriobotryae water extraction, filter, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract; With said extracted thing mix homogeneously, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described compositionss are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100567045A CN101491605A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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| CNA2008100567045A CN101491605A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972029A (en) * | 2010-06-21 | 2011-02-16 | 戴俊腾 | Tianshan yacon granule and preparation method thereof |
| CN108783414A (en) * | 2018-05-04 | 2018-11-13 | 中南大学 | A kind of Guava Leaf health-caring product capable of reducing blood sugar and preparation method thereof |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
| CN110464757A (en) * | 2019-08-16 | 2019-11-19 | 云南绿华食品有限公司 | A kind of composition and preparation method thereof reducing blood glucose using Guava Leaf |
-
2008
- 2008-01-23 CN CNA2008100567045A patent/CN101491605A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972029A (en) * | 2010-06-21 | 2011-02-16 | 戴俊腾 | Tianshan yacon granule and preparation method thereof |
| CN101972029B (en) * | 2010-06-21 | 2012-08-01 | 戴俊腾 | Tianshan yacon granule and preparation method thereof |
| CN108783414A (en) * | 2018-05-04 | 2018-11-13 | 中南大学 | A kind of Guava Leaf health-caring product capable of reducing blood sugar and preparation method thereof |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
| CN110464757A (en) * | 2019-08-16 | 2019-11-19 | 云南绿华食品有限公司 | A kind of composition and preparation method thereof reducing blood glucose using Guava Leaf |
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Open date: 20090729 |