CN101491537A - Glacial acetic acid chitosan composite antibiotic liquid - Google Patents
Glacial acetic acid chitosan composite antibiotic liquid Download PDFInfo
- Publication number
- CN101491537A CN101491537A CNA2008100430771A CN200810043077A CN101491537A CN 101491537 A CN101491537 A CN 101491537A CN A2008100430771 A CNA2008100430771 A CN A2008100430771A CN 200810043077 A CN200810043077 A CN 200810043077A CN 101491537 A CN101491537 A CN 101491537A
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- chitosan
- acetic acid
- glacial acetic
- chitosan composite
- tinea
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a glacial acetic acid-chitosan composite antibacterial liquid, and belongs to the technical field of medical antibacterium. The glacial acetic acid-chitosan composite antibacterial liquid cures skin diseases caused by bacterial infection such as tinea corporis, tinea pedis, and the like, and can also be used for antibacterium on the surfaces of objects, and the like. In the glacial acetic acid-chitosan composite antibacterial liquid, the concentration of glacial acetic acid is between 0.5 and 30 percent, and the content of chitosan is between 0.05 and 15 percent. The irritation of the glacial acetic acid-chitosan composite antibacterial liquid to the skin is smaller than that of the prior glacial acetic acid solution, the antibacterium can keep the moistening of the skin, and the sterilizing therapeutic effect is obvious.
Description
Technical field
The invention belongs to field of medical article technology.
Background technology
Chitosan is the product behind the chitin deacetylase base, is positively charged natural polysaccharide, and is extremely abundant at occurring in nature content; have broad spectrum antibacterial, and can be degraded into Fructus Vitis viniferae amine by lysozyme in vivo, be absorbed by the body then; with human body cell good affinity is arranged, nontoxic, non-immunogenicity.Chitosan is as a kind of novel animal derived natural antibacterial material, as a kind of ideal anti-biotic material, should have promptly and imitate spectrum, long-acting, no matter the stable safety that reaches is organically at present, inorganic, natural, synthetically all do not reach this requirement, have only the advantage of comprehensive various anti-biotic materials, could further improve the effectiveness of anti-biotic material.Glacial acetic acid is the acetum of high concentration, in the department of dermatologry value that has a wide range of applications, be mainly used to treat various tinea, as tinea corporis, tinea manus and pedis, tinea unguium, tinea versicolor etc., though the high concentration glacial acetic acid has good therapeutical effect, but it has certain side effect, so the present invention adopts the glacial acetic acid of suitable concn and chitosan to be made into antimicrobial fluid, under the prerequisite that keeps clinical efficacy, the concentration of the glacial acetic acid of Jiang Diing has reduced side effect greatly.
Summary of the invention
The objective of the invention is to, a kind of novel antimicrobial fluid with therapeutical effect that is used for is provided, be chitosan to be dissolved in form a kind of liquid in the glacial acetic acid solution with antibacterial action, be used for the treatment of the tinea that various mycetes cause, as tinea corporis, tinea manus and pedis, tinea unguium, tinea versicolor etc., also can be used for other bacterial body surfaces and infect, the antimicrobial occasion of also available other needs is as the sterilization of water dispenser etc.
The technical solution adopted for the present invention to solve the technical problems is: utilize the chitosan of natural resources to be dissolved in the glacial acetic acid solution of 0.5%-30%, make the solution (satisfying different antibiotic needs) of various concentration, wherein chitosan comprises oligo-chitosan and the high chitosan of molecular weight 161-500000, to be used for the antibiotic requirement of different needs.
Glacial acetic acid chitosan composite antibiotic liquid provided by the invention has broad spectrum antibacterial, for escherichia coli, mycete, staphylococcus aureus or the like pathogenic bacterium all have good killing action, in clinical each section value that has a wide range of applications, as are used for treating various tinea, as various bacterial diseases such as tinea corporis, tinea manus and pedis, tinea unguium, tinea versicolor, and can also be used for various external sterilizations, the sterilization as water dispenser etc. has good popularization and development prospect.
Specific embodiments
Example 1 is placed on 50 gram chitosans in 5% glacial acetic acid solution, stirs until whole dissolvings, makes 5% glacial acetic acid chitosan composite solution, sterilization fill finished product.
Example 2 is placed on 50 gram chitosans in 10% glacial acetic acid solution, stirs until whole dissolvings, makes 10% glacial acetic acid chitosan composite solution, sterilization fill finished product.
Example 3 is placed on 10 gram chitosans in 5% glacial acetic acid solution, stirs until whole dissolvings, makes 1% glacial acetic acid chitosan composite solution, sterilization fill finished product.
Example 4 is placed on 10 gram chitosans in 10% glacial acetic acid solution, stirs until whole dissolvings, makes 1% glacial acetic acid chitosan composite solution, sterilization fill finished product.
Claims (4)
1. a glacial acetic acid chitosan composite antibiotic liquid is characterized in that, this solution contains chitosan or chitosan derivatives or both mixture of 0.05%-15%.
2. glacial acetic acid according to claim 1 is characterized in that, the concentration of glacial acetic acid is 0.5-30%.
3. chitosan according to claim 1 is characterized by high chitosan and oligo-chitosan, and chitosan derivatives comprises carboxymethyl chitosan, the sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan or chitosan quaternary amine.
4. glacial acetic acid chitosan composite antibiotic liquid according to claim 3 is characterized in that, contains described carboxymethyl chitosan, sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan or chitosan quaternary amine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100430771A CN101491537A (en) | 2008-01-24 | 2008-01-24 | Glacial acetic acid chitosan composite antibiotic liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100430771A CN101491537A (en) | 2008-01-24 | 2008-01-24 | Glacial acetic acid chitosan composite antibiotic liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101491537A true CN101491537A (en) | 2009-07-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100430771A Pending CN101491537A (en) | 2008-01-24 | 2008-01-24 | Glacial acetic acid chitosan composite antibiotic liquid |
Country Status (1)
| Country | Link |
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| CN (1) | CN101491537A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20110042A1 (en) * | 2011-02-14 | 2012-08-15 | Alberto Denis Tombolato | COMBINATION OF SUBSTANCES FOR THE TREATMENT OF ONICOMYCOSIS AND DERMATOMYCOSIS |
| CN103147307A (en) * | 2012-12-06 | 2013-06-12 | 青岛海芬海洋生物科技有限公司 | Embroidery artware antibiosis and mildew-proof care solution |
| CN104434994A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Mucocutaneous disinfectant |
| CN104434995A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Preparation method of mucocutaneous disinfectant |
| CN105943549A (en) * | 2016-05-10 | 2016-09-21 | 赫尔森江苏医药有限公司 | Film-forming and bacterium-resisting agent for treating onychomycosis and preparation process of agent |
| CN108451972A (en) * | 2018-05-16 | 2018-08-28 | 亳州市新健康科技有限公司 | A kind of chitin chelated microelement preparation and its preparation process and application |
| CN108633879A (en) * | 2018-04-20 | 2018-10-12 | 袁杰 | A kind of circulating water sterilizing agent |
-
2008
- 2008-01-24 CN CNA2008100430771A patent/CN101491537A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20110042A1 (en) * | 2011-02-14 | 2012-08-15 | Alberto Denis Tombolato | COMBINATION OF SUBSTANCES FOR THE TREATMENT OF ONICOMYCOSIS AND DERMATOMYCOSIS |
| CN103147307A (en) * | 2012-12-06 | 2013-06-12 | 青岛海芬海洋生物科技有限公司 | Embroidery artware antibiosis and mildew-proof care solution |
| CN104434994A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Mucocutaneous disinfectant |
| CN104434995A (en) * | 2014-11-28 | 2015-03-25 | 成都顺发消洗科技有限公司 | Preparation method of mucocutaneous disinfectant |
| CN105943549A (en) * | 2016-05-10 | 2016-09-21 | 赫尔森江苏医药有限公司 | Film-forming and bacterium-resisting agent for treating onychomycosis and preparation process of agent |
| CN108633879A (en) * | 2018-04-20 | 2018-10-12 | 袁杰 | A kind of circulating water sterilizing agent |
| CN108451972A (en) * | 2018-05-16 | 2018-08-28 | 亳州市新健康科技有限公司 | A kind of chitin chelated microelement preparation and its preparation process and application |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090729 |