CN101489628A - Toothpaste composition - Google Patents
Toothpaste composition Download PDFInfo
- Publication number
- CN101489628A CN101489628A CNA2007800262765A CN200780026276A CN101489628A CN 101489628 A CN101489628 A CN 101489628A CN A2007800262765 A CNA2007800262765 A CN A2007800262765A CN 200780026276 A CN200780026276 A CN 200780026276A CN 101489628 A CN101489628 A CN 101489628A
- Authority
- CN
- China
- Prior art keywords
- dentifrice composition
- opaque
- arbitrary aforementioned
- zinc salt
- chelating agen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
An opaque toothpaste composition comprises: water; a zinc salt; a chelating agent for the zinc salt, the chelating agent having a log Ks1 as herein defined of from 3.0 to 7.0; calcium carbonate at from 10% to 70% by weight of the toothpaste composition; a monofluorophosphate salt; and trisodium phosphate.
Description
The present invention relates to a kind of opaque dentifrice composition, it comprises bioactive zinc salts in chalk formulation.The present invention also relates to make the method for above-mentioned composition.
EP-A1-0740932 (Unilever) discloses a kind of visually clarifying gel-like dentifrice, its comprise the zinc salt more soluble in water than zinc citrate, can with bonded aminoacid of zinc and low refractive index class abrasive silica.
US5470561 (Klugkist) discloses a kind of antiplaque collutory that comprises zinc salt and triclosan.Said composition may also comprise glycine, and pH is between 4 and 8, and preferably between 5 to 7, preferred pH is 6.
GBA-2052978 (Unilever) discloses a kind of zinc salt and glycine of comprising, and pH is 4.5 to 8.0 toothpaste.
US 5632972 (Williams) discloses a kind of by sending zinciferous first component of bag and comprising second component of bicarbonate so that gums and periodontal tissue are injured minimized method.
US4425325 (Sapone etc.) discloses a kind of biological activity zinc ion that comprises with glycine, and has the oral cavity composition of the pH through regulating between about 4.5 to 9.4.
GB1319247 (Beecham INC) discloses a kind of non-liquid anti-calculus tooth composite, zinc, copper or zirconium composite that it comprises the tooth excipient and fluoridizes beta-diketon.
US4325939 (Shah) discloses preparation and has been used for tooth composite, the particularly alkali metal of collutory compositions or zinc citrate ammonium.
US5188820 (Cummins etc.) discloses the oral cavity composition such as dentifrice, and it comprises tin salt such as stannous fluoride or ditin diphosphate and the zinc salt mixture such as zinc citrate.
In first aspect, the invention provides opaque dentifrice composition according to claim 1.
Mono-fluor phosphate provides fluorion for dentifrice composition, and fluorion is a kind of effective dental caries agent.But mono-fluor phosphate is unstable in containing the toothpaste of Chalk, therefore needs stabilizing agent.Though tertiary sodium phosphate (TSP) is a kind of suitable stabilizers,, therefore TSP can not be joined in the zinciferous toothpaste in the past because free zinc ion and TSP reaction form zinc phosphate.Zinc phosphate is not the high-quality source of biological available zinc.Therefore, by introducing the chelating agen of zinc, mono-fluor phosphate and zinc can keep its level behind long pot life.
Zinc salt exists with 0.01 to 5% of dentifrice composition weight, is preferably 0.5 to 3.0% of composition weight.Wherein, zinc salt is solvable on a small quantity, zinc citrate for example, the log K of cheland and zinc ion
s1 is equal to or greater than the log K of acid anion and zinc ion in a small amount of solvable zinc salt
s1.But, preferred water-soluble zinc salt.Suitable zinc salt comprises zinc chloride, zinc sulfate and zinc fluoride.Preferred zinc salt is a zinc sulfate, and it provides aforesaid optimal balance in this class prescription.
The preferred potassium of alkali metal or sodium, most preferably sodium.
Alkali metal phosphate preferred single, double or triphosphate, most preferably triphosphate.
The chelating agen that is preferred for zinc salt has from 4.0 to 6.0 log K
s1.Log K
sThe 1st, the logarithm of one-level stability constant, it is specific ligand and special metal ion, is zinc among the present invention, between binding affinity.For example, when chelating agen was glycine, the one-level stability constant was the binding affinity between a glycine ligand and the free zinc ion, and by as give a definition: K
s1=[ML]/[M] .[L], wherein [ML] is the concentration of metal-ligand complex, [M] is that concentration and [L] of free metal ion is the concentration of free ligand.Since [L] is the function of pH value of solution, because the required initial deprotonation of part, as reference point, described log K
s1 value is at the pH7.4 record.
Chelating agen exists with 0.001 to 6% of composition weight, 0.5 to 4.0% of preferred composition weight.Preferred chelating agen comprises the alkali metal salt of citric acid, alanine, glycine and serine.The balance of optimum is provided between the solubility that most preferably alkali metal citrates, particularly potassium citrate, potassium citrate most preferably, its zinc salt in can protecting the Chalk system are avoided hydrolysis (causing the formation of carbon dioxide) and kept zinc salt and the biological utilisation.
Grinding system exists with 10 to 70% of dentifrice composition weight, and is preferred 20 to 60%, and most preferably dentifrice composition weight 35 to 45%.
Phosphoric acid alkali metal exists with 0.01 to 2% weight of composition weight, and is preferred 0.15 to 1%, and special preferred composition weight 0.2 to 0.5%.
Be used for grinding system of the present invention based on calcium carbonate.This does not stop the non-calcium carbonate abrasives of extra use, such as silicon dioxide, tungsten carbide and carborundum.
In preferred embodiments, grinding system comprises the calcium carbonate of at least 50% weight, more preferably the calcium carbonate of at least 75% weight, the most preferably calcium carbonate of at least 95% weight.In the most preferred embodiment of the present invention, grinding system comprises the calcium carbonate of 100% weight, although calcium carbonate and additional grinding agent mixture are also possible.
Preferred calcium carbonate comprises the natural whiting of fine ground, because about the interaction aspect of itself and zinc salt, have astonishing stability.The natural whiting of term fine ground (FGNC) is known term in this field, and suitable like this example is disclosed among the US2003/0072721A1 (Riley), is introduced into this paper as a reference about definition, kind and the grade content of FGNC.In any case, mean the Chalk that obtains by grinding stone lime stone or marble deposits with regard to FGNC.Preferably, FGNC comprises median particle size based on weight between 1 to 15 μ m, and the BET surface area is 0.5 to 3m
2Particulate matter between the/g.
Preferably comprise fluoride sources according to compositions of the present invention, such as single fluorophosphoric acid alkali metal salt, preferably sodium monofluorophosphate.Such fluoride sources will be to provide from 100 to 2000ppm, preferably from such the measuring now of 900 to 1500ppm free fluorine ion.
Dentifrice composition according to the present invention comprises further composition commonly used in this area, such as:
Antimicrobial, for example, chlorhexidine, the Sanguinarine extract, metronidazole, quaternary ammonium compound is cetylpyridinium chloride for example, biguanide, for example chlorhexidine digluconate, hexetidine, octenidine, the western pyridine of Ah Lai; With the halogenated bisphenol chemical compound, such as 2,2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol);
Antiinflammatory is such as ibuprofen, BTS-18322, aspirin, indomethacin etc.;
The dental caries agent, such as sodium fluoride and stannous fluoride, amine fluoride, sodium monofluorophosphate, sodium trimetaphosphate and casein;
The bacterial plaque buffer is such as carbamide, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium;
Vitamin is such as vitamin A, C and E;
Plant extract;
Desensitizer, for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt;
Anticalculus agent, for example alkali metal pyrophosphate, the polymer that contains hypophosphites, organic phosphonate and phosphoric acid citrate (phosphocitrates) etc.;
Biomolecule, for example bacteriocin, antibody, enzyme etc.;
Spice, for example Herba Menthae and Oleum menthae;
Proteinaceous material is such as collagen;
Antiseptic;
Opacifier;
Coloring agent;
The pH regulator agent;
Sweeting agent;
Pharmaceutical acceptable carrier, for example, starch, sucrose, water or water/pure system etc.;
Surfactant, for example anion, nonionic, cation and amphion or amphoteric surfactant;
Microgranule abrasiveness material, for example silicon dioxide, aluminium oxide, calcium carbonate, dicalcium phosphate, calcium pyrophosphate, hydroxyapatite, trimetaphosphate, insoluble hexametaphosphate or the like, comprise agglomerant microgranule abrasiveness material, content is generally 3 to 60% of dentifrice composition weight.Preferred grinding agent is Chalk and silicon dioxide, more preferably the natural whiting of fine ground.
Wetting agent is such as glycerol, sorbitol, propylene glycol, xylitol, lactose etc.;
Binding agent and thickening agent, such as sodium carboxymethyl cellulose, hydroxyethyl-cellulose (
), xanthan gum, arabic gum etc., and synthetic polymer, such as polyacrylate and carboxy vinyl polymer such as
Also can comprise can the enhanced activity composition polymerizable compound sent of antimicrobial for example;
The buffer agent and the salt of buffering dentifrice composition pH and ionic strength; And
Other optional members that can comprise are bleachs for example, such as peroxide peroxide diphosphonic acid potassium (potassium peroxydiphosphate) for example; Effervescent system is the sodium bicarbonate/citric acid system for example, color change system, or the like.
Also can use liposome to improve sending of active component or stability.
In second aspect, the invention provides and a kind ofly make the method for opaque dentifrice composition according to first aspect, this method comprise form chelates of zinc solution and with the step of buffer pH before the calcium carbonate that suspends mixes to the pH value that is equal to or higher than the calcium carbonate water float.Further material can join in the last mixture such as spice.
Remove in operation and comparative example, or outside other places that offer some clarification on, all numerals of the amount of illustrative material should be understood that to be modified by speech " approximately " in this description.
Term " comprise " mean be not limited to any subsequently the statement element but comprise main or accessory non-designed element with functional importance.In other words, listed step, element or option do not need exhaustive.Whenever speech " comprises " or " having " when being used, and it is suitable with above-mentioned definition " comprising " that these terms mean.
Referring now to the following non-limiting examples discussion according to embodiment of the present invention.
Embodiment 1
The following example preparation is according to a kind of embodiment of the present invention.It is manufactured like this: at first Zinc vitriol and glycine (with other submembers) are mixed, use sodium hydroxide buffer pH to 8.5 to 9.5.Then, calcium carbonate, surfactant and structural agent are added in the chelates of zinc mixture.Add spice at last.
| Composition | ％(w/w) |
| The natural whiting of fine ground (Addon 1015) | 40.00 |
| Sorbitol (70% aqueous solution) | 15.00 |
| Thickening property silicon dioxide | 3.00 |
| Sodium carboxymethyl cellulose | 0.90 |
| Spice | 1.10 |
| Sweeting agent | 0.23 |
| Sodium lauryl sulfate | 2.50 |
| Zinc vitriol | 2.745 |
| Glycine | 3.584 |
| Sodium hydroxide | 1.12 |
| Formalin | 0.10 |
| Sodium monofluorophosphate | 0.76 |
| Tertiary sodium phosphate | 0.5 |
| Water | To 100 |
Claims (14)
1. opaque dentifrice composition, it comprises:
Water;
Zinc salt;
The chelating agen that is used for zinc salt, this chelating agen have from 3.0 to 7.0 logK as defined herein
s1;
10% to 70% calcium carbonate for dentifrice composition weight;
Mono-fluor phosphate; With
Alkali metal phosphate.
2. according to the opaque dentifrice composition of claim 1, wherein compositions has from 8.0 to 10.0 pH.
3. according to the opaque dentifrice composition of claim 1 or 2, wherein alkali metal phosphate is a tertiary sodium phosphate.
4. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein calcium carbonate is the natural whiting of fine ground.
5. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein compositions comprises fluoride sources.
6. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein zinc salt is a water-soluble zinc salt.
7. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein zinc salt is a zinc sulfate.
8. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein chelating agen is a glycine.
9. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein chelating agen is a serine.
10. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein chelating agen is an alanine.
11. according to the opaque dentifrice composition of arbitrary aforementioned claim, wherein chelating agen is an alkali metal citrates.
12. according to the opaque toothpaste of arbitrary aforementioned claim, it comprises and is selected from dental caries agent, anticalculus agent, halitosis agent, brightener for tooth, gingivitis reagent and and their reagent of mixture.
13. according to the opaque toothpaste of arbitrary aforementioned claim, tertiary sodium phosphate wherein exists to 1% with 0.1 of composition weight.
14. make the method for opaque dentifrice composition, wherein toothpaste comprises water, zinc salt, is used for the chelating agen of zinc salt, this chelating agen has from 3.0 to 7.0 log K as defined herein
s1 and with 10% to 70% grinding agent that exists of dentifrice composition weight, described grinding agent comprises calcium carbonate, and described method comprises:
Form chelates of zinc solution and with buffer pH before calcium carbonate mixes to the pH that is equal to or higher than the calcium carbonate water float with randomly add any further material in any stage.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117088 | 2006-07-13 | ||
| EP06117088.2 | 2006-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101489628A true CN101489628A (en) | 2009-07-22 |
Family
ID=37546780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800262765A Pending CN101489628A (en) | 2006-07-13 | 2007-07-02 | Toothpaste composition |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2046454A1 (en) |
| CN (1) | CN101489628A (en) |
| BR (1) | BRPI0711979A2 (en) |
| WO (1) | WO2008006725A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837469A (en) * | 2012-10-12 | 2015-08-12 | 荷兰联合利华有限公司 | Oral care composition |
| TWI551300B (en) * | 2009-10-26 | 2016-10-01 | 美國棕欖公司 | Oral care composition |
| CN109908017A (en) * | 2013-12-19 | 2019-06-21 | 高露洁-棕榄公司 | Oral care composition |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010060653A2 (en) | 2008-11-27 | 2010-06-03 | Amc Abrasives Marketing & Consulting Llp | Dental care products with diamond particles |
| EA027276B1 (en) * | 2012-10-12 | 2017-07-31 | Юнилевер Н.В. | Oral care composition |
| JP6236773B2 (en) * | 2012-11-28 | 2017-11-29 | ライオン株式会社 | Opaque dentifrice composition |
| MX354227B (en) | 2012-12-24 | 2018-02-19 | Colgate Palmolive Co | Oral care composition. |
| WO2015195124A1 (en) | 2014-06-18 | 2015-12-23 | Colgate-Palmolive Company | Dentifrice comprising zinc - amino acid complex and phosphates |
| US20230372213A1 (en) * | 2022-05-20 | 2023-11-23 | The Procter & Gamble Company | Oral care composition comprising opacifier |
| US20230372209A1 (en) * | 2022-05-20 | 2023-11-23 | The Procter & Gamble Company | Oral care composition comprising opacifier |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283385A (en) * | 1980-05-09 | 1981-08-11 | Richardson-Merrell Inc. | Dentifrices with improved soluble fluoride availability |
| US5632972A (en) * | 1994-06-30 | 1997-05-27 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Method for treating gingival and periodontal tissues |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| CA2224274C (en) * | 1995-08-08 | 2001-07-31 | Enamelon, Inc. | Remineralizing products and methods for teeth |
| US6861048B2 (en) * | 1999-04-08 | 2005-03-01 | Warner-Lambert Company | Dentifrice compositions having reduced abrasivity |
| WO2003017964A1 (en) * | 2001-08-24 | 2003-03-06 | Unilever N.V. | Oral composition comprising an alkylhydroxybenzoate |
-
2007
- 2007-07-02 WO PCT/EP2007/056627 patent/WO2008006725A1/en active Application Filing
- 2007-07-02 BR BRPI0711979-8A patent/BRPI0711979A2/en not_active IP Right Cessation
- 2007-07-02 CN CNA2007800262765A patent/CN101489628A/en active Pending
- 2007-07-02 EP EP07765752A patent/EP2046454A1/en not_active Ceased
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI551300B (en) * | 2009-10-26 | 2016-10-01 | 美國棕欖公司 | Oral care composition |
| CN104837469A (en) * | 2012-10-12 | 2015-08-12 | 荷兰联合利华有限公司 | Oral care composition |
| CN104837469B (en) * | 2012-10-12 | 2017-09-26 | 荷兰联合利华有限公司 | Oral care composition |
| CN109908017A (en) * | 2013-12-19 | 2019-06-21 | 高露洁-棕榄公司 | Oral care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008006725A1 (en) | 2008-01-17 |
| BRPI0711979A2 (en) | 2012-01-17 |
| EP2046454A1 (en) | 2009-04-15 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20090722 |