CN101485836A - Oral capsule for treating neck, waist and leg pain diseases and preparation method thereof - Google Patents
Oral capsule for treating neck, waist and leg pain diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an orally taken traditional Chinese medicine capsule special for treating neck, waist and leg pains caused by various causes, which comprises the following formulation by weight (in terms of preparing 1,000 granules of orally taken capsules as standard): 9 to 90 grams of wild celery, 9 to 90 grams of radix gentianae macrophyllae, 9 to 90 grams of parsnip, 3 to 30 grams of wild ginger, 12 to 120 grams of loranthus parasiticus, 9 to 90 grams of angelica, 9 to 90 grams of white paeony root, 8 to 80 grams of Szechuan lovage rhizome, 9 to 90 grams of prepared rhizome of rehmannia, 10 to 100 grams of eucommia bark, 10 to 100 grams of achyranthis root, 9 to 90 grams of desertliving cistanche, 12 to 120 grams of teasel root, 5 to 50 grams of cinnamon core, 12 to 120 grams of radix codonopsitis, 12 to 120 grams of hoantchy root, 6 to 60 grams of rhizoma gastrodiae, 12 to 120 grams of Chinese wolfberry, 10 to 100 grams of kudzuvine root, 10 to 100 grams of akebia stem, 10 to 100 grams of Atractylis ovata, 10 to 100 grams of clematis root, 6 to 60 grams of safflower, 6 to 60 grams of cortex moutan, 6 to 60 grams of libanotus, 6 to 60 grams of myrrh, 10 to 100 grams of papaya, 12 to 120 grams of rhizoma drynariae, 12 to 120 grams of caulis milletiae, 10 to 100 grams of notoginseng, 10 to 100 grams of ophidian, 9 to 90 grams of scorpion, 2 to 15 chilopod, 10 to 100 grams of daemonorops draco, 12 to 120 grams of eupolyphaga, and 0 to 30 grams of radix glycyrrhizae preparata; and the quality of the 36 gouts of traditional Chinese medicine accords with prescription of Chinese pharmacopoeia, and the components are prepared into powder according to a preparation method for the traditional Chinese medicine, and canned into capsules.
Description
Technical field
The present invention relates to a kind ofly to boil oral capsule that forms and preparation method thereof by pure drug matching, refer in particular to a kind of cervicobrachia, lumbodynia and leg pain for the treatment of, drug matching boils oral capsule that forms and preparation method thereof.
Background technology
Cervicobrachia, lumbodynia and leg pain mainly is the general name based on the clinical manifestation symptom grouping of vertebra, bones of limbs joint, incidence, dizzy, pain, numb limbs and tense tendons, the dyskinesia.It comprises tens of kinds of diseases such as vertebrae joint, vertebra Spinal nerve maincenter, extremities joint, muscle, soft tissue aseptic inflammation and entrapment syndrome.The main pathogenic factor of this disease is that the insufficiency of vital energy and blood that long-term wind-engaging, cold, wet, heat, heresy and impairment caused by overstrain cause is an exopathogenic factor; It is endogenous cause of ill that liver spleen kidney deficiency, governor vessel lose void, and cause QI and blood lose and the expectorant stasis of blood in accumulate, limbs are lacked of proper care, zang-fu disharmony, passages through which vital energy circulates does not pursue and onset.Treatment neck, waist and leg pain basic skills is as follows at present:
One, western medical treatment generally is divided into two kinds of conservative treatment and operative therapys:
1, conservative treatment: general symptomatic treatment, use that some are invigorated blood circulation, anti-inflammatory analgesic, medicine such as replenish the calcium, can stablize the state of an illness at short notice, effect is all right, but recurs easily, because of general doctor trained in Western medicine Zhi Biao does not effect a permanent cure.
2, operative therapy: effective.But the expense height has a big risk, and post-operative complication is many.
Two, tcm therapy: generally adopt acupuncture, massage and massage, or take Chinese medicines such as some invigorating kidney, promoting blood circulations, detumescence, tendons relaxing and meridians dredging pain relieving, effect is all right, in the market, the Chinese patent medicine kind of treatment neck, waist and leg pain is various, determines but effect is very difficult, easily causes the patient to select.
Therefore, a kind of highly effective Therapeutic Method is not arranged as yet at present, necessary this is further studied.
Summary of the invention
The objective of the invention is to deficiency, further improve the treatment by Chinese herbs method, propose the better pure drug matching of a kind of therapeutic effect and boil oral capsule that forms and preparation method thereof at existing treatment treatment neck, waist and leg pain method.
The objective of the invention is to realize by following proposal: a kind of special for treating a variety of causes causes the extract oral capsule of neck, waist and leg pain disease, forms (is standard by 1000 oral capsules of preparation) by weight ratio with prescription by following Chinese medicine:
1, prescription:
Radix Angelicae Pubescentis 9~90 gram Radix Gentianae Macrophyllae 9~90 gram Radix Saposhnikoviaes 9~90 gram Herba Asaris 3~30 grams
Herba Taxilli 12~120 gram Radix Angelicae Sinensis 9~90 gram Radix Paeoniae Albas 9~90 gram Rhizoma Chuanxiongs 8~80 grams
Radix Rehmanniae Preparata 9~90 gram Cortexs Eucommiae 10~100 gram Radix Achyranthis Bidentataes 10~100 gram Herba Cistanches 9~90 grams
Radix Dipsaci 12~120 gram Cortex Cinnamomi 5~50 gram Radix Codonopsis 12~120 gram Radixs Astragali 12~120 grams
Rhizoma Gastrodiae 6~60 gram Fructus Lyciis 12~120 gram Radix Puerariaes 10~100 gram Caulis Akebiaes 10~100 grams
The Rhizoma Atractylodis Macrocephalae 10~100 gram Radix Clematidis 10~100 gram Flos Carthamis 6~60 gram Cortex Moutans 6~60 grams
Olibanum 6~60 gram Myrrhas 6~60 gram Fructus Chaenomeliss 10~100 gram Rhizoma Drynariae 12~120 grams
Caulis Spatholobi 12~120 gram Radix Notoginseng 10-100 gram Zaocys 10~100 gram Scorpios 9~90 grams
2~15 Sanguis Draxonis of Scolopendra, 10~100 gram TUBIECHONG, 12~120 gram Radix Glycyrrhizae Preparata, 0~30 gram
Above-mentioned Chinese medicine 36 flavors, quality all meets the Chinese Pharmacopoeia regulation, is prepared into powder according to Chinese medicinal preparation method, canned again one-tenth capsule.
2, the side separates:
Our according to Ming Dynasty well-known doctor Zhang Jingyue " Jing Yue's complete work, deficient " piece of writing day: " ...; The damage of diet muscle, it is controlled at spleen; The damage of all blood fascias, it is controlled liver; The damage of marrow, it is controlled at kidney; Right gas master is in lung, and changes in essence; Refreshing main in the heart, and change in gas; The muscle master is in spleen, and autochthonal in fire; All blood is hidden in liver, and albefaction is in the spleen bone; The marrow master is in bone, and be subjected in the five internal organs, this its also inseparable ".
So take into account inside and outside treatment neck, waist and leg pain disease is suitable, so disease mainly is wind-engaging, cold, wet, heat and invades pathogen numbness resistance meridians outward and the impairment caused by overstrain QI and blood is an exopathogenic factor that liver spleen kidney deficiency, governor vessel thanks to void are endogenous cause of ill.Cause that disharmony between QI and blood, expectorant accumulate in becoming silted up, limbs apraxia, internal organs apraxia, passages through which vital energy circulates by and onset.
It mainly is according to above-mentioned rule that the present invention treats neck waist-leg disease disease, and the prescription emphasis exists: the method for tonifying liver spleen kidney, strong muscle cold expelling, blood circulation promoting and blood stasis dispelling, dredge the meridian passage and opinion is controlled.
The prescription source mainly is a plus-minus on name side " three types of Arthralgia decoction " " women's good recipe ", basis, " JUANBI TANG " " Young man Tibetan side ".Cooperate the insects medicine again, strengthen the effect of expelling wind to alleviate pain, curative effect will be better like this.
Because cervicobrachia, lumbodynia and leg pain is comparatively obstinate, it is difficult to prolong for a long time, and the main cause damp is detained, spleen channel is stranded, inside and outside combined pathogens.And both share energy dampness, spleen invigorating, spleen fortune is wet go, and benefit has been attacked in this side's medication, reinforcement and elimination in combination.The ancient prescription basis is arranged, meet traditional Chinese medical science principle of medication.Also embodied simultaneously the modern usefulness of ancient prescription.
In the side: Radix Angelicae Pubescentis, Herba Asari, Radix Saposhnikoviae, Radix Gentianae Macrophyllae, Cortex Cinnamomi are searched kidney channel wind and cold, and warming the liver menses deficiency and coldness stagnates, and can stopping numbness pain be monarch drug again.The Cortex Eucommiae, Herba Taxilli, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Dipsaci, Rhizoma Chuanxiong, Rhizoma Drynariae, Cortex Moutan, Herba Cistanches, Fructus Lycii have invigorating the liver and kidney, bone and muscle strengthening and the merit that nourishes blood is a ministerial drug, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Poria, Caulis Akebiae, Radix Glycyrrhizae Preparata enriching spleen-QI are adjuvant drug with the merit that helps diet fortuneization.Radix Angelicae Sinensis, Radix Notoginseng, Flos Carthami, Fructus Chaenomelis, Caulis Spatholobi, Olibanum, Myrrha, Sanguis Draxonis, Cortex Moutan, Radix Clematidis, Zaocys, TUBIECHONG, Scorpio, Scolopendra activating blood circulation to dissipate blood stasis, dredge the meridian passage, reducing swelling and alleviating pain is a messenger drug, all medicines cooperate, attack to mend and take into account, both tonifying liver spleen kidneys, ends lumbago at the bone and muscle strengthening and the removing dampness of dispeling the wind again, activating blood circulation to dissipate blood stasis.So treatment of suitable neck, waist and leg pain disease.
3, pharmaceutical formulation characteristics of the present invention:
1. it is foundation that should side's medication leading policy is cured holy Zhang Jingyue " Jing Yue's complete work is deficient " theory with the Ming Dynasty, and in conjunction with the evolution process of human body natural's aging, focusing on the prescription on the invigorating liver and spleen kidney, because of liver decreases, the blood fascia will decrease, and the blood fascia decreases, and just causes the perichondral malnutrition of bone easily.In case perichondrium lacks nutrition, will cause the fascia atrophy, just is prone to spinal instability, intervertebral disk hernia and osteoarticular retrograde affection.
2. select Herba Asari, Cortex Cinnamomi among the we for use, when being classified as principal agent, the main cause Herba Asari can be searched kidney channel wind and cold, and Cortex Cinnamomi is joined Radix Angelicae Sinensis, can warming the liver menses deficiency and coldness stagnate.Radix Saposhnikoviae, Radix Gentianae Macrophyllae dispel the wind, the cold-damp heresy is gone out and can pain relieving, more than each medicine be mainly holagogues of we.
3. select for use the Cortex Eucommiae, parasitism, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata etc. to be used for the merit of kidney-replenishing blood-nourishing among the we.Join Radix Codonopsis, Poria, Radix Glycyrrhizae Preparata, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae merit of QI invigorating is arranged.More than each medicine be the main the kidney invigorating liver spleens of we.
4. selecting medicines such as Flos Carthami, Radix Notoginseng, Sanguis Draxonis among the we for use mainly is to promote hematoma to dissipate.Join in addition Olibanum, Myrrha, Radix Clematidis, Caulis Spatholobi again and add the merit that the insects medicine plays activating blood circulation to dissipate blood stasis, dredge the meridian passage, stopping numbness pain.
So the arthralgia pain patient has concurrently weakened body resistance and the domination of pathogen more.If it is pure with tonic or holagogue then can the stagnate heresy or the positive deficiency of vital energy.So during the treatment cervicobrachia, lumbodynia and leg pain, must adopt to attack to mend and take into account.The method that collateral dredging promoting blood circulation and stopping pain multiple-effect is share so just can reach good therapeutic effect.
4, this medicine mainly acts on:
1. function: dispel the wind, tremble with fear, damp, tonifying liver spleen kidney, activating blood circulation to dissipate blood stasis, bone and muscle strengthening, stopping numbness pain.
2. cure mainly: the cervicobrachia, lumbodynia and leg pain, rheumatic arthritis, rheumatic arthralgia pain, prolapse of lumbar intervertebral disc, lumbar muscle strain and the osteoarticular retrograde affection that cause because of deficiency of the liver and kindey, QI and blood deficiency.
5, preparation method of the present invention is as follows:
We are by 36 flavor drug matchings such as Herba Asari, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Cortex Cinnamomi.Manufacture method all according to the regulation of relevant Chinese medicine 6 kind new medicines in " provisions for new drugs approval ", is used modern technologies, and preparation method, quality standard carry out.
1. at first 33 flavor Chinese medicines such as Radix Angelicae Pubescentis, Herba Taxilli, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis are put into the Chinese medicine extraction device and soak about 1-3 hours, wait to soak the back extraction medicinal liquid that finishes, preferably extract repeatedly 2 times.So just can fully extract more effective components of Chinese medicinal.
2. further concentrate putting into concentrator behind the good medical filtration of extraction, concentrate good clear paste liquid and carry out dried again, the dry powder of handling well is standby.
3. the same Radix Angelicae Pubescentis of Rhizoma Gastrodiae preparation method, Herba Asari are the same in the side.The dry powder that (just single extract drugs) handled well is standby.
4. Cortex Moutan in the side, Sanguis Draxonis is ground into fine powder respectively after high temperature drying standby.
5. preparation:
With the medicated powder for preparing for three times, send into sterilizing room and carry out mixing and stirring.Enter conventional capsules preparation technique again, restrain or the 0.45 quality standard fill that restrains, after fill is good, get final product through aseptic packaging by every 0.3.
The present invention is an absorption successive dynasties well-known doctor experience prescription, at existing pathogenic factor of neck, waist and leg pain and characteristics, sums up and inquires into through clinical practice for many years specially, and repeated screening is tested on prescription, mixes the prescription of optimal treatment neck, waist and leg pain at last.Through clinic trial for many years, therapeutic effect is good, and does not have secondary toxic action again, is suitable for treating the neck, waist and leg pain disease that a variety of causes causes.
The specific embodiment
The present invention is further illustrated will to engage specific embodiment below.
Embodiment one
The extract oral capsule of the neck, waist and leg pain disease that a kind of special for treating a variety of causes causes, form (is standard by 1000 oral capsules of preparation) by weight ratio with prescription by following Chinese medicine:
1, prescription:
Radix Angelicae Pubescentis 9~90 gram Radix Gentianae Macrophyllae 9~90 gram Radix Saposhnikoviaes 9~90 gram Herba Asaris 3~30 grams
Herba Taxilli 12~120 gram Radix Angelicae Sinensis 9~90 gram Radix Paeoniae Albas 9~90 gram Rhizoma Chuanxiongs 8~80 grams
Radix Rehmanniae Preparata 9~90 gram Cortexs Eucommiae 10~100 gram Radix Achyranthis Bidentataes 10~100 gram Herba Cistanches 9~90 grams
Radix Dipsaci 12~120 gram Cortex Cinnamomi 5~50 gram Radix Codonopsis 12~120 gram Radixs Astragali 12~120 grams
Rhizoma Gastrodiae 6~60 gram Fructus Lyciis 12~120 gram Radix Puerariaes 10~100 gram Caulis Akebiaes 10~100 grams
The Rhizoma Atractylodis Macrocephalae 10~100 gram Radix Clematidis 10~100 gram Flos Carthamis 6~60 gram Cortex Moutans 6~60 grams
Olibanum 6~60 gram Myrrhas 6~60 gram Fructus Chaenomeliss 10~100 gram Rhizoma Drynariae 12~120 grams
Caulis Spatholobi 12~120 gram Radix Notoginseng 10-100 gram Zaocys 10~100 gram Scorpios 9~90 grams
2~15 Sanguis Draxonis of Scolopendra, 10~100 gram TUBIECHONG, 12~120 gram Radix Glycyrrhizae Preparata, 0~30 gram
Above-mentioned Chinese medicine 36 flavors, quality all meets the Chinese Pharmacopoeia regulation, is prepared into powder according to Chinese medicinal preparation method, canned again one-tenth capsule.
2, preparation method
1. at first 33 flavor Chinese medicines such as Radix Angelicae Pubescentis, Herba Taxilli, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis are put into the Chinese medicine extraction device and soak about 1-3 hours, wait to soak the back extraction medicinal liquid that finishes, preferably extract repeatedly 2 times.So just can fully extract more effective components of Chinese medicinal.
2. further concentrate putting into concentrator behind the good medical filtration of extraction, concentrate good clear paste liquid and carry out dried again, the dry powder of handling well is standby.
3. the Rhizoma Gastrodiae preparation method is the same with 33 flavor Chinese medicines such as Radix Angelicae Pubescentiss in the side, is the single extract drugs, and the dry powder of handling well is standby.
4. Cortex Moutan in the side, Sanguis Draxonis is ground into fine powder respectively after high temperature drying standby.
5. preparation:
With the medicated powder for preparing for three times, send into sterilizing room and carry out mixing and stirring.Enter capsules preparation technique again, restrain or the 0.45 quality standard fill that restrains, after fill is good, get final product through aseptic packaging by every 0.3.
Therapeutic effect is analyzed
Medicine of the present invention is a kind of pure compound Chinese medicinal preparation.Safety of medicine, have no side effect.Observe by the treatment to 200 routine neck, waist and leg pain patients, effect is as follows:
1. the state of an illness: all based on neck, waist and leg pain.Physical data is divided into men and women's matched group according to all ages and classes section patient, totally 200 routine patients, male's 82 examples, women's 118 examples.36~45 years old 86 age example, 46~55 years old 72 example, 56 years old~65 years old 42 example.Onset when examining, the course of disease 36 examples below 3 months, 4~10 months 93 examples, 10 months~3 years 71 examples (seeing Table 1-2).Each is organized all patients and all passes through Western medicine or Chinese traditional treatment.Medicines such as Therapeutic Method all adopts and stimulates the menstrual flow, promoting blood circulation and stopping pain and hormone therapy, effect is also not obvious, this group case generally all has cervical region and chronic problem medical history, mostly be that the time that works by day is grown or sitting pain for very.Myasthenia of limbs severe pain, finger tip numbness are tightly expanded, gone up in cervical region discomfort, giddy, headache, back.During lumbago: lower limb from hip to vola portion, and traction Ipsilateral sciatica.During acute attack, from hip one side or two sides along the line to the calf numb pain unbearably, can not walk and sit for sleeping in.Sensation muscle beat twinge etc.Observing does not locally have red and swollenly, and two lower limb thicknesses have difference, ordinary circumstance can, deep-thready pulse and tight.
2. by the treatment of medicine of the present invention a period of time, its therapeutic outcome is as follows:
Two groups of totally 200 examples, mean treatment is about 2~3 months, and is the longest 5 months, the shortest 1 month, and 152 examples that wherein take a turn for the better account for 76%, alleviate 40 examples, account for 20%, invalid 8 examples, total effective rate is 96% (seeing Table 3).
Table 1: each age group therapeutic effect of male relatively
Table 2: each age group therapeutic effect of women relatively
Table 3: two groups of contrasts of men and women therapeutic effect
(P<0.05) effective percentage=take a turn for the better+alleviate=96%.
Claims (2)
1, a kind of oral capsule for the treatment of cervicobrachia, lumbodynia and leg pain by following Chinese medicine by weight ratio and prescription, is that standard is formed by 1000 oral capsules of preparation:
Radix Angelicae Pubescentis 9~90 gram Radix Gentianae Macrophyllae 9~90 gram Radix Saposhnikoviaes 9~90 gram Herba Asaris 3~30 grams
Herba Taxilli 12~120 gram Radix Angelicae Sinensis 9~90 gram Radix Paeoniae Albas 9~90 gram Rhizoma Chuanxiongs 8~80 grams
Radix Rehmanniae Preparata 9~90 gram Cortexs Eucommiae 10~100 gram Radix Achyranthis Bidentataes 10~100 gram Herba Cistanches 9~90 grams
Radix Dipsaci 12~120 gram Cortex Cinnamomi 5~50 gram Radix Codonopsis 12~120 gram Radixs Astragali 12~120 grams
Rhizoma Gastrodiae 6~60 gram Fructus Lyciis 12~120 gram Radix Puerariaes 10~100 gram Caulis Akebiaes 10~100 grams
The Rhizoma Atractylodis Macrocephalae 10~100 gram Radix Clematidis 10~100 gram Flos Carthamis 6~60 gram Cortex Moutans 6~60 grams
Olibanum 6~60 gram Myrrhas 6~60 gram Fructus Chaenomeliss 10~100 gram Rhizoma Drynariae 12~120 grams
Caulis Spatholobi 12~120 gram Radix Notoginseng 10-100 gram Zaocys 10~100 gram Scorpios 9~90 grams
2~15 Sanguis Draxonis of Scolopendra, 10~100 gram TUBIECHONG, 12~120 gram Radix Glycyrrhizae Preparata, 0~30 gram
Above-mentioned 36 flavor medicines are prepared into powder according to Chinese medicinal preparation method, canned again one-tenth capsule.
2, a kind of preparation method that realizes the oral capsule of the described treatment cervicobrachia, lumbodynia and leg pain of claim 1, its preparation method is as follows:
A, at first Radix Angelicae Pubescentis, Herba Taxilli, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis etc. 33 flavor Chinese medicines are put into the Chinese medicine extraction device and soak about 1-3 hours, wait to soak the back that finishes and extract medicinal liquid, extract repeatedly 2 times;
B, put into concentrator behind the good medical filtration and further concentrate, concentrate good clear paste liquid and carry out dried again extracting, the dry powder of handling well standby '
The Rhizoma Gastrodiae preparation method is the same with 33 flavor Chinese medicines such as Radix Angelicae Pubescentis in C, the side, single extract drugs just, the dry powder of handling well standby '
Cortex Moutan in D, the side, Sanguis Draxonis is ground into fine powder respectively after high temperature drying standby;
E, preparation:
With the medicated powder for preparing for three times, send into sterilizing room and carry out mixing and stirring.Enter capsules preparation technique again, restrain or the 0.45 quality standard fill that restrains, after fill is good, get final product through aseptic packaging by every 0.3.
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