CN101472642B - 微型针辊组件 - Google Patents
微型针辊组件 Download PDFInfo
- Publication number
- CN101472642B CN101472642B CN2007800226769A CN200780022676A CN101472642B CN 101472642 B CN101472642 B CN 101472642B CN 2007800226769 A CN2007800226769 A CN 2007800226769A CN 200780022676 A CN200780022676 A CN 200780022676A CN 101472642 B CN101472642 B CN 101472642B
- Authority
- CN
- China
- Prior art keywords
- micro
- roller assembly
- neddle
- internals
- external member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002952 polymeric resin Substances 0.000 claims abstract description 15
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims description 10
- 229920005992 thermoplastic resin Polymers 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920002988 biodegradable polymer Polymers 0.000 claims description 3
- 239000004621 biodegradable polymer Substances 0.000 claims description 3
- 229920001187 thermosetting polymer Polymers 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 description 46
- 239000003814 drug Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 11
- 229920000747 poly(lactic acid) Polymers 0.000 description 10
- 239000004626 polylactic acid Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000002615 epidermis Anatomy 0.000 description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 6
- 239000004926 polymethyl methacrylate Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
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- 239000004697 Polyetherimide Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 229920002492 poly(sulfone) Polymers 0.000 description 4
- 229920001601 polyetherimide Polymers 0.000 description 4
- 229920006324 polyoxymethylene Polymers 0.000 description 4
- 241001481760 Erethizon dorsatum Species 0.000 description 3
- -1 alkyl acetate Chemical compound 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 2
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- 238000013461 design Methods 0.000 description 2
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- 239000003822 epoxy resin Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920001568 phenolic resin Polymers 0.000 description 2
- 239000005011 phenolic resin Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920005749 polyurethane resin Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- DGLFSNZWRYADFC-UHFFFAOYSA-N chembl2334586 Chemical compound C1CCC2=CN=C(N)N=C2C2=C1NC1=CC=C(C#CC(C)(O)C)C=C12 DGLFSNZWRYADFC-UHFFFAOYSA-N 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003351 stiffener Substances 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
- B29C45/561—Injection-compression moulding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Massaging Devices (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2006-0061788 | 2006-07-03 | ||
KR1020060061787A KR100753872B1 (ko) | 2006-07-03 | 2006-07-03 | 마이크로 니들 롤러와 그 제조 방법 |
KR1020060061788A KR100792382B1 (ko) | 2006-07-03 | 2006-07-03 | 마이크로 니들 롤러와 그 성형 금형 |
KR1020060061788 | 2006-07-03 | ||
KR10-2006-0061787 | 2006-07-03 | ||
KR1020060061787 | 2006-07-03 | ||
KR1020070013559A KR100941770B1 (ko) | 2007-02-09 | 2007-02-09 | 마이크로 니들 롤러 |
KR1020070013559 | 2007-02-09 | ||
KR10-2007-0013559 | 2007-02-09 | ||
PCT/KR2007/003121 WO2008004781A1 (en) | 2006-07-03 | 2007-06-27 | Micro neddle roller assembly |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101472642A CN101472642A (zh) | 2009-07-01 |
CN101472642B true CN101472642B (zh) | 2013-04-10 |
Family
ID=39216964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800226769A Active CN101472642B (zh) | 2006-07-03 | 2007-06-27 | 微型针辊组件 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR100792382B1 (ko) |
CN (1) | CN101472642B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR200453182Y1 (ko) | 2008-05-01 | 2011-04-15 | 김기태 | 전기치료가 가능한 피부미용기 |
CN101904796A (zh) * | 2010-07-05 | 2010-12-08 | 苏州工业园区博友钛钢科技有限公司 | 一种可振动*** |
JP5677013B2 (ja) | 2010-10-14 | 2015-02-25 | Ntn株式会社 | 美容/健康ローラ用軸受装置および美容/健康ローラ |
CN105999536B (zh) * | 2016-05-09 | 2019-01-18 | 上海交通大学 | 同步注药皮肤滚针 |
KR102178324B1 (ko) * | 2018-06-26 | 2020-11-13 | 주식회사 정우티앤씨 | 피부약물의 공급장치가 구비된 마이크로 니들 롤러 |
KR102175310B1 (ko) | 2018-08-28 | 2020-11-06 | 연세대학교 산학협력단 | 슈팅 마이크로 구조체 모듈 및 이의 어플리케이터 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011622A (en) * | 1975-10-14 | 1977-03-15 | Kagil Corporation | Attachment for a roller applicator |
US4625366A (en) * | 1984-10-18 | 1986-12-02 | Staedtler & Uhl. | Opening cylinder for open-end spinning machines or the like |
US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10063634B4 (de) * | 2000-12-20 | 2006-01-12 | Liebl, Horst, Zelsheim | Vorrichtung und Verfahren zum Einbringen eines Wirkstoffs in die Haut |
US20070191761A1 (en) * | 2004-02-23 | 2007-08-16 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
KR200395359Y1 (ko) * | 2005-06-27 | 2005-09-08 | (주)클리니칼레졸루션아시아 | 마이크로니들 롤러 |
-
2006
- 2006-07-03 KR KR1020060061788A patent/KR100792382B1/ko active IP Right Grant
-
2007
- 2007-06-27 CN CN2007800226769A patent/CN101472642B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011622A (en) * | 1975-10-14 | 1977-03-15 | Kagil Corporation | Attachment for a roller applicator |
US4625366A (en) * | 1984-10-18 | 1986-12-02 | Staedtler & Uhl. | Opening cylinder for open-end spinning machines or the like |
US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
Also Published As
Publication number | Publication date |
---|---|
CN101472642A (zh) | 2009-07-01 |
KR100792382B1 (ko) | 2008-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB02 | Change of applicant information |
Address after: Seoul, Korea Applicant after: Lotte Chemical Corporation Applicant after: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY Address before: Seoul, Korea Applicant before: Hunan Petrochemical Corporation Applicant before: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: HONAM PETROCHEMICAL CORP. TO: LOTTE CHEMICAL CO., LTD. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |