CN101461872B - Medicament composition for treating erectile dysfunction and preparation method thereof - Google Patents
Medicament composition for treating erectile dysfunction and preparation method thereof Download PDFInfo
- Publication number
- CN101461872B CN101461872B CN2009100580650A CN200910058065A CN101461872B CN 101461872 B CN101461872 B CN 101461872B CN 2009100580650 A CN2009100580650 A CN 2009100580650A CN 200910058065 A CN200910058065 A CN 200910058065A CN 101461872 B CN101461872 B CN 101461872B
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine composition
- fructus
- erection
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medicine composition for treating erection functional disorder. The medicine composition is a preparation consisting of eight herbal medicines, namely, epimedium herb, common cnidium fruit, caltrop, nidus vespae, centipede, bloodsucker, globethistle root and grass-leaved sweetflag, and has the advantages of simple and unique prescription, low price and remarkable curative effects. Clinical research shows that the medicine composition can remarkably increase the grade of international index of erection function (questionnaire) (IIEF-5); moreover, the medicine composition can obviously increase the erection rigidity of a patient and prolongs the duration of penis erection without generating side effects; and the total cure rate is 88 percent and clinical cure rate is 54 percent. The invention also discloses a preparation method of the medicine composition. The medicine composition is prepared in proportion respectively through pretreatments such as crushing or solvent extraction according to different characteristics of each traditional Chinese medicine.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating erection disturbance.Be the Chinese patent medicine that primary raw material is prepared from Herba Epimedii, Fructus Cnidii, Fructus Tribuli, Nidus Vespae, Scolopendra, Hirudo, Radix Rhapontici, Rhizoma Acori Graminei specifically.The invention still further relates to manufacturing method for above mentioned medicine.
Background technology
Erection disturbance (ED) claim sexual impotence again.Refer generally to penis anorthosis as a rule, though or can erect to keep and erect and have sexual intercourse, be modal clinically male sexual disorder, 52% ED that suffers from was in various degree arranged among the man according to statistics in 40～70 years old.Its treatment can be divided into Noninvasive and invasive is treated two types, and noninvasive laser therapy means psychotherapy, Drug therapy and negative pressure of vacuum erection treatment.The invasive treatment comprises urethra administration, the injection of spongy body active medicine, penile prosthesis is implanted and the operative treatment of vascular sexual impotence.Invasive treatment has certain traumatic, and complication is many, and the patient is difficult for accepting; Drug therapy mainly is to be main with Western medicine at present; Mostly be phosphodiesterase-5 (PDE-5) inhibitor: like sldenafil (viagra; Pfizer), Vardenafil (Ai Lida, Beyer Co., Ltd) though etc. curative effect certainly, cost an arm and a leg; General patient is difficult to bear, and can cause like headache, orthostatic hypotension, cardiovascular adverse effects etc. and make us unacceptable side-effects.
Though research at present has the Chinese patent medicine of some treatment erection disturbance, but still can not satisfy patient's needs, and its prescription composition is all complicated, flavour of a drug are more, and price is higher, unsatisfactory curative effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine and corresponding preparations thereof of treating the erection disturbance determined curative effect.Its characteristics have: can comparatively fast improve patient's erection function, the hardness of increase erecing, prolong the persistent period of erecing, and low price, have no side effect.
Solution of the present invention is based on the pathogenetic understanding of motherland's medical science to ED, according to oneself clinical experience for many years, from numerous Chinese medicines, confirms the effective Chinese medicine of a series of treatment ED earlier, through clinical repeated validation, screens compound Chinese medicinal preparation again.Can comparatively fast improve patient's erection function, the hardness of increase erecing, prolong the persistent period of erecing, and low price, have no side effect.
The present invention is a kind of pharmaceutical composition of treating erection disturbance, it is characterized in that it comprises Herba Epimedii, Fructus Cnidii, Fructus Tribuli, Nidus Vespae, Scolopendra, Hirudo, Radix Rhapontici, Rhizoma Acori Graminei eight herbal medicines.
Medicine of the present invention can be the medicine of said dosage form on any pharmaceutics.
The preparation of this medicine can prepare by the conventional method on the various medicaments, as:
Scolopendra, Hirudo powder are broken into fine powder; Herba Epimedii, Fructus Tribuli, Nidus Vespae, Fructus Cnidii, Rhizoma Acori Graminei, Radix Rhapontici extract by conventional method with ethanol or water etc., concentrate, drying, extract, then with extract and Scolopendra, Hirudo fine powder mixing, process the medicine of required dosage form.
In the above preparation process, if necessary, can add adjuvant commonly used in an amount of pharmaceutics, like starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium etc.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
(1) symptoms such as the soreness of the waist and knees that causes of treatment ED, aversion to cold and cold limbs, cold sperm seminal emission increase international index of erectile function (questionnaire) (IIEF-5) to mark, and improve the quality of living.
(2) obviously increase patient's erection hardness.
(3) obviously prolong the erection persistent period.
(4) have no side effect.
(5) stable curative effect.
For showing clinical effectiveness of the present invention, with reference to " the clinical research guideline of new Chinese medicine treatment sexual impotence ", select 20～60 years old, be diagnosed as patient's 50 examples of erection disturbance, through the objective clinical observation of system.Minimum 22 years old of age, maximum 60 years old, average 44.18 ± 4.66 years old.The course of disease is the shortest 7 months, and is the longest 155 months, average 36.18 ± 9.43 months.13 examples that the state of an illness is slight (26%), moderate 25 examples (50%), severe 12 examples (24%).One month observation period.Respectively at taking medicine preceding and taking medicine the back observation:
(1) safety indexes: blood pressure, pulse, blood, urine, excrement three big routines and electrocardiogram, liver, the inspection of kidney brake
(2) health giving quality index:
(a) IIEF-5 scoring.
(b) tcm syndrome scoring.
(3) untoward reaction is observed
Comprise that gastrointestinal reaction, nervous system abnormality, skin and muscle are unusual etc.
Each item index changes shown in table 1～4 before and after the treatment
(IIEF-5) variation of marking of table 1 international index of erectile function (questionnaire)
Annotate: * * representes and preceding relatively p＜0.01 of treatment (down together).
The scoring of table 2 tcm syndrome changes
Annotate: the p value representation is the same.
The evaluation of table 3 total effects
Do not see obvious adverse reaction in the drug administration process, electrocardiogram before and after taking medicine, liver, renal function, blood, routine urinalysis do not have significant change.
The specific embodiment
The present invention forms as follows by weight ratio:
Herba Epimedii 10-40 part, Fructus Cnidii 10-30 part, Fructus Tribuli 20-50 part, Nidus Vespae 10-30 part, Scolopendra 1-5 part, Hirudo 1-5 part, Radix Rhapontici 10-30 part, Rhizoma Acori Graminei 10-20 part.
Preferred weight proportioning of the present invention is:
Herba Epimedii 10-25 part, Fructus Cnidii 10-20 part, Fructus Tribuli 25-40 part, Nidus Vespae 10-20 part, Scolopendra 1-3 part, Hirudo 1-3 part, Radix Rhapontici 10-20 part, Rhizoma Acori Graminei 5-15 part.
The method for preparing of medicine of the present invention is an example for 6 parts with 20 parts of Herba Epimedii, 12 parts of Fructus Cnidiis, 31 parts of Fructus Tribulis, 16 parts of Nidus Vespaes, 1.5 parts of Scolopendras, 1.5 parts of Hirudos, 12 parts of Radix Rhapontici, Rhizoma Acori Graminei, can be with reference to following method:
(1) directly Scolopendra, Hirudo powder are broken into fine powder; Herba Epimedii, Fructus Tribuli, Fructus Cnidii, Radix Rhapontici, Rhizoma Acori Graminei, Nidus Vespae water are pressed decocting method extract, concentrate, drying gets extract, then Scolopendra, Hirudo fine powder is mixed evenly with extract, adds appropriate amount of starch, granulates, and capsule is processed in filling.
(2) directly Scolopendra, Hirudo powder are broken into fine powder; Fructus Cnidii is used ethanol percolate extraction, reclaim solvent, drying gets extract; Herba Epimedii, Fructus Tribuli, Radix Rhapontici, Rhizoma Acori Graminei, Nidus Vespae water are pressed decocting method extract, concentrate, drying, extract, with each extract and Scolopendra, Hirudo fine powder mixing, tablet is processed in granulation then.
(3) directly Scolopendra, Hirudo powder are broken into fine powder; Fructus Cnidii, Fructus Tribuli are used alcohol reflux, reclaim solvent, drying gets extract; Herba Epimedii, Radix Rhapontici, Rhizoma Acori Graminei, Nidus Vespae water are pressed decocting method extract, concentrate, drying, extract, with each extract and Scolopendra, Hirudo fine powder mixing, add appropriate amount of starch then, granule is processed in granulation.
Claims (5)
1. a pharmaceutical composition of treating erection disturbance is characterized in that it is to be processed by following raw materials by weight proportions: Herba Epimedii 10-40 part, Fructus Cnidii 10-30 part, Fructus Tribuli 20-50 part, Nidus Vespae 10-30 part, Scolopendra 1-5 part, Hirudo 1-5 part, Radix Rhapontici 10-30 part, Rhizoma Acori Graminei 10-20 part.
2. a pharmaceutical composition of treating erection disturbance is characterized in that it is to be processed by following raw materials by weight proportions: Herba Epimedii 10-25 part, Fructus Cnidii 10-20 part, Fructus Tribuli 25-40 part, Nidus Vespae 10-20 part, Scolopendra 1-3 part, Hirudo 1-3 part, Radix Rhapontici 10-20 part, Rhizoma Acori Graminei 5-15 part.
3. pharmaceutical composition according to claim 2 is characterized in that it is to be processed by following raw materials by weight proportions: 20 parts of Herba Epimedii, 12 parts of Fructus Cnidiis, 31 parts of Fructus Tribulis, 16 parts of Nidus Vespaes, 1.5 parts of Scolopendras, 1.5 parts of Hirudos, 12 parts of Radix Rhapontici, 6 parts of Rhizoma Acori Graminei.
4. according to each described pharmaceutical composition in the claim 1 to 3, it is characterized in that the dosage form of said pharmaceutical composition is selected from granule or tablet or capsule.
5. prepare the method for each described pharmaceutical composition in the claim 1 to 3, it is characterized in that: Scolopendra, Hirudo powder are broken into fine powder; Herba Epimedii, Fructus Cnidii, Fructus Tribuli, Nidus Vespae, Radix Rhapontici, Rhizoma Acori Graminei water or alcoholic solution are extracted by conventional method, concentrate, dry, then with each extract and Scolopendra, Hirudo fine powder mixing, the adding adjuvant is processed required forms of pharmaceutical compositions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100580650A CN101461872B (en) | 2009-01-08 | 2009-01-08 | Medicament composition for treating erectile dysfunction and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100580650A CN101461872B (en) | 2009-01-08 | 2009-01-08 | Medicament composition for treating erectile dysfunction and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101461872A CN101461872A (en) | 2009-06-24 |
| CN101461872B true CN101461872B (en) | 2012-06-13 |
Family
ID=40802808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100580650A Expired - Fee Related CN101461872B (en) | 2009-01-08 | 2009-01-08 | Medicament composition for treating erectile dysfunction and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101461872B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826000A (en) * | 2015-04-27 | 2015-08-12 | 李海松 | Compound traditional Chinese medicine preparation for treating kidney deficiency and blood stasis type erectile dysfunction |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147382A (en) * | 1995-10-10 | 1997-04-16 | 陈玉梅 | Kangweiling tablet and its prepn |
| CN1176799A (en) * | 1996-09-16 | 1998-03-25 | 王�琦 | Drug for treating sexual impotence |
| CN1843394A (en) * | 2006-02-14 | 2006-10-11 | 郭凯 | Medicine for treating erection dysfunction and preparation method thereof |
| CN1989990A (en) * | 2005-12-27 | 2007-07-04 | 郭凯 | Medicine for treating erection dysfunction and preparation method thereof |
-
2009
- 2009-01-08 CN CN2009100580650A patent/CN101461872B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147382A (en) * | 1995-10-10 | 1997-04-16 | 陈玉梅 | Kangweiling tablet and its prepn |
| CN1176799A (en) * | 1996-09-16 | 1998-03-25 | 王�琦 | Drug for treating sexual impotence |
| CN1989990A (en) * | 2005-12-27 | 2007-07-04 | 郭凯 | Medicine for treating erection dysfunction and preparation method thereof |
| CN1843394A (en) * | 2006-02-14 | 2006-10-11 | 郭凯 | Medicine for treating erection dysfunction and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 瞿岳云."阳痿非尽肾阳虚论".《中医药学刊》.2006,第24卷(第2期),228-231. |
| 高军等."中医药治疗阳萎临床研究进展".《河北中医》.2007,第29卷(第2期),171-174. |
| 黄晨昕."兴阳饮治疗阳痿40例".《江苏中医》.1994,第15卷(第2期),20. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101461872A (en) | 2009-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102764339B (en) | Maca composition for improving sexual dysfunction and preparation method and application thereof | |
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN102397372A (en) | Medicinal composition and pharmaceutical preparation and application thereof to treating irritable bowel syndrome | |
| CN1899342A (en) | Oral medicine for treating diabetes and its use | |
| CN104491740A (en) | Traditional Chinese medicine composition for treating liver cancer and preparation method of traditional Chinese medicine composition | |
| CN1989990B (en) | Medicine for treating erection dysfunction and preparation method thereof | |
| CN102552705B (en) | Traditional Chinese medicinal capsule for treating lumbar disc herniation and femoral head necrosis | |
| CN100391494C (en) | Compound chinese preparation for treating pain symptom and its preparing process | |
| CN101461872B (en) | Medicament composition for treating erectile dysfunction and preparation method thereof | |
| CN102743717A (en) | Traditional Chinese medicine capsule for treating uterine prolapse | |
| CN100387245C (en) | Medicine for treating erection dysfunction and preparation method thereof | |
| CN100455309C (en) | Compound Chinese medicinal preparation for treating gynecological inflammation and preparation method thereof | |
| CN104383349A (en) | Drug for postoperative recovery of bladder cancer and preparation method of drug for postoperative recovery of bladder cancer | |
| CN1899428B (en) | Chinese medicine preparation for treating pain and its preparing method | |
| CN107744552A (en) | It can strengthen muscles and bones, go silt detumescence, the composition of relaxing tendons and activating collaterals and preparation method and application | |
| CN103142928A (en) | Iliacus muscle oral liquid and preparation method thereof | |
| CN100534482C (en) | Soft capsule for treating vascular headaehe | |
| CN100457160C (en) | Medicine for curing cervical spondylopathy and its preparation | |
| CN105920189A (en) | Traditional Chinese medicine composition for treating talalgia due to liver-kidney deficiency and preparation method thereof | |
| CN101732539B (en) | Medicament for treating gynecological diseases and preparation method thereof | |
| CN105477384A (en) | Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition | |
| CN106074813A (en) | A kind of Chinese medicine fumigation and washing soaking agent treating talalgia and preparation method thereof | |
| CN104225014B (en) | A kind of Tibetan medicine for the treatment of diabetes | |
| CN101088554B (en) | Psoriasis treating Chinese medicine composition and its preparation process | |
| CN103599397A (en) | Traditional Chinese medicine composition for treating chronic renal insufficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Guo Kai Document name: Notice of application for publication of patent for invention and entry into the substantive examination procedure |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120613 Termination date: 20150108 |
|
| EXPY | Termination of patent right or utility model |