CN101450157A - Medicine composition for treating chronic bronchitis and asthma - Google Patents
Medicine composition for treating chronic bronchitis and asthma Download PDFInfo
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- CN101450157A CN101450157A CNA2007101505408A CN200710150540A CN101450157A CN 101450157 A CN101450157 A CN 101450157A CN A2007101505408 A CNA2007101505408 A CN A2007101505408A CN 200710150540 A CN200710150540 A CN 200710150540A CN 101450157 A CN101450157 A CN 101450157A
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Abstract
The invention discloses a pharmaceutical composition for treating chronic bronchitis and asthma, which is composed of: ambroxol hydrochloride 5-20mg, water chestnut100-30g, astragalus 10-20g, Radix Codonopsis 10-50g, girardinia suborbiculata 20-50g, licorice roots northwest origin 6-20g and pharmaceutic adjuvants. The pharmaceutical composition for treating chronic bronchitis and asthma of the invention achieves obvious cooperative synergisms in relieve the dyspnea caused by bronchial asthma and chronic bronchitis, both its cure rate and control rate is above 95%; and it achieves the advantages of substantial curative effect, convenience in taking and carrying and low production cost, is suitable for mass production.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, relate to a kind of pharmaceutical composition for the treatment of chronic bronchitis and asthma.
Background technology
Respiratory tract infection is a kind of commonly encountered diseases, frequently-occurring disease, and is all higher in domestic its incidence and mortality of world's model, and the trend of increase is arranged.It is China human mortality's a key factor.According to statistics China more than 50 years old the bronchitis sickness rate of middle-aged and elderly people be about 15%～30%.Find that by clinical observation for many years respiratory system disease often shows as cough, expectoration, or with breathing hard, pant etc., severe patient can concurrent emphysema, pulmonary heart disease etc.And the breathing heavily of respiratory system disease, cough, expectorant, scorching four diseases is general common symptons, often exist simultaneously, reciprocal causation.
The ambroxol hydrochloride chemistry is by name: the amino amino 3.5-dibromo-benzyl of trans-4-[(2-)] cyclohexanol hydrochloridumi.It is the respiratory mucus regulator of a new generation, has the superior usefulness of eliminating the phlegm, and the synthetic and secretion of alveolar surfactant is had significant facilitation.Can increase the secretion of respiratory mucosa serous gland, reduce the mucous gland secretion, thereby reduce sputum viscosity; Also can promote the secretion of pulmonary surfactant, increase the bronchus ciliary movement, make sputum be easy to expectoration.Ambroxol hydrochloride is that the most effectively relieving cough and expelling phlegm is present clinically at present, what gone on the market has ambroxol hydrochloride tablet, capsule, syrup, injection, slow releasing capsule or the like, be applicable to acute, the chronic respiratory system diseases of and expectoration dysfunction undesired, for example: the treatment of eliminating the phlegm of chronic bronchitis acute exacerbation, asthmatic bronchitis, bronchial asthma with the sputum secretion.
Chronic bronchitis with cough, expectorant, to breathe heavily be main clinic symptoms, belongs to diseases range such as Chinese medicine cough, phlegm retention, cough with asthma.The traditional Chinese medical science sage of the past has the argumentation of " lung is not hindered and do not coughed, and spleen is not hindered not chronic cough, kidney do not hinder do not breathe heavily ", and all exopathogen invasion and attack attackings the lung first, impairment of dispersing and descending function of the lung be mechanism of qi superinverse and cause cough, dyspnea with rapid and short breath then; If chronic cough is not healed then lung qi is impaired, table Wei Bugu, body is resisted the exopathogen ability drop, and is easy to catch cold, and the heresy invasion and attack that cause the diseases caused by exogenous pathogenic factor six climate exopathogens cause the recurrent cough.If the cold-evil does not remove for many years, cause the spleen YANG deficiency, failure of the spleen to transport and transform then, being difficult of essence of water and grain given birth to and is QI and blood, and accumulatively wet raise phlegm is stopped up on the phlegm-damp in lung on the contrary, causes impairment of purifying and descending function of the lung and causes cough, abundant expectoration, asthma.If insufficiency of kidney-YANG, decline of the fire from the gate of life is YANG failing to warm spleen-YANG then, cause the spleen YANG deficiency, deficiency of spleen-YANG then in burnt dysfunction of the spleen in transportation and transformation, can not make the defeated lung that is distributed in of body fluid, lung loses the power of logical accent, water is wet for poly-, make expectorant and become drink, on steep in lung, the lungs of being detained, obstructing airway, thus imbalance falls in lung qi a surname, causes symptoms such as cough, abundant expectoration, asthma, at this moment because deficiency of spleen-YANG and kidneyYANG, the patient also has symptoms such as coldness of the body with chills, waist abdomen cold type of pain, lack of appetite Mental fatigue, abdominal distention uncomfortable in chest, face light yellow complexion, easy to catch cold, tired easily antiperspirant, loose stool every day 3-4 time, hyposexuality.As seen, deficiency of spleen-YANG and kidneyYANG is the main pathological basis of primary disease, and the internal organs deficiency and coldness that has deficiency of spleen-YANG and kidneyYANG to cause is the place of its pathological essence, therefore, the ＂ strengthening spleen, tonifying kidney, warming the interior cold expelling ＂ is the key point of effecting a permanent cure.Ambroxol hydrochloride and Corm Eleocharitis, the Radix Astragali, Radix Codonopsis, Sedum spectabile Boreau, Radix Glycyrrhizae Chinese medicine extract compatibility aspect treatment chronic bronchitis and the asthma, had the obvious synergistic effect.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of chronic bronchitis and asthma, ambroxol hydrochloride and Corm Eleocharitis, the Radix Astragali, Radix Codonopsis, Sedum spectabile Boreau, Radix Glycyrrhizae Chinese medicine extract compatibility are made the bonded pharmaceutical composition in Chinese and Western.
Being implemented of the technology of the present invention by following content:
A kind of pharmaceutical composition for the treatment of chronic bronchitis and asthma is characterized in that it is made up of ambroxol hydrochloride and Chinese medicine extract: wherein ambroxol hydrochloride 5-20mg, Corm Eleocharitis 10-30g, Radix Astragali 10-20g, Radix Codonopsis 10-50
G, Sedum spectabile Boreau 20-50g, Radix Glycyrrhizae 6-20g, pharmaceutic adjuvant are an amount of.
The ratio of weight and number of ambroxol hydrochloride of the present invention and Chinese medicine extract is 1:5-100, preferred 1:5-1:50 wherein, every single dose medicine carrying content of preferred every single dose ambroxol-hydrochloride-containing and Chinese medicine extract is 2:7.5mg-12:30mg, preferred 2:7.5mg-12:25mg, the best is 2:7.5mg.Wherein every single dose medicine carrying content refers to the specification of each preparation institute pastille.
Chinese medicine extract of the present invention is with Corm Eleocharitis 10-30g, Radix Astragali 10-20g, Radix Codonopsis 10-50g, Sedum spectabile Boreau 20-50g, Radix Glycyrrhizae 6-20g, with second alcohol and water reflux, extract, 2 times, each 3-10 hour, each with 1000ml ethanol and 600ml backflow, filtrate is condensed into extractum, adds 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, are concentrated into to do after each 250ml, extract filter and merge to obtain extract.
Pharmaceutical composition of the present invention comprises: conventional tablet, dispersible tablet, oral cavity disintegration tablet, effervescent tablet, chewable tablet, enteric coatel tablets, capsule, granule or enteric coated capsule.
Pharmaceutical composition of the present invention is characterized in that described pharmaceutic adjuvant adjuvant comprises: filler, binding agent, disintegrating agent, lubricant, correctives or aromatic.Filler comprises: xylitol, dextrin, starch, pregelatinized Starch, mannitol or microcrystalline Cellulose; Described binding agent comprises starch, polyvidone, hypromellose, hyprolose, Polyethylene Glycol, medicinal alcohol or water; Described disintegrating agent comprises starch, low-substituted hydroxypropyl cellulose or carmethose.Lubricant comprises Pulvis Talci, magnesium stearate, Polyethylene Glycol-4000 or Polyethylene Glycol-6000; Described correctives comprises sucrose, sorbitol, saccharin sodium or maltose alcohol; Described aromatic comprises: Herba Menthae, Pericarpium Citri junoris tincture or Oleum Cinnamomi; Artificial fragrant spermatophore is drawn together Fructus Citri tangerinae essence, flavoring banana essence or Fructus Citri Limoniae essence.
Chinese medicine of the present invention has: Corm Eleocharitis, the Radix Astragali, Radix Codonopsis, Sedum spectabile Boreau, Radix Glycyrrhizae.Wherein Corm Eleocharitis is used as medicine from ancient times.The traditional Chinese medical science thinks that the Corm Eleocharitis nature and flavor are sweet, cold, the effect that has removing heat-phlegm, appetite-stimulating indigestion-relieving, promotes the production of body fluid and moisturize, make eye bright and sober up, the clinical treatment that is applicable to diseases such as lung-dryness syndrome due to deficiency of YIN, cough ant phlegm, excessive thirst constipation, drunk lethargy.In the respiratory infectious disease epidemic season, eat the control that Corm Eleocharitis helps epidemic encephalitis, measles, pertussis and acute pharyngolaryngitis.
The Radix Astragali is perennial leguminous herbaceous plant.Sweet in the mouth is flat, the effect that has QI invigorating to give birth to sun, the spleen and stomach regulating, the lung moistening and production of body fluid promoting, eliminate the phlegm; Cure mainly the empty intestinal of taste, spontaneous sweating, under-inflation, carbuncle are not burst, detumescent toxin expelling etc.
The Radix Codonopsis chemical constituent: contain atractyloide I, IIIatractylenolide I, III), nicotinic acid, 5-hydroxyl-2-methoxypyridine, codopiloic acid, Syringin, syringic aldehyde, vanillic acid, and plant sterol, triterpenes, monosaccharide, polysaccharide etc.Nature and flavor are flat, sweet in the mouth.Function cures mainly, invigorating the spleen and replenishing QI, and spleen invigorating is promoted the production of body fluid.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the extremity asthenia.
Sedum spectabile Boreau: Urticaceae Sedum spectabile Boreau platymiscium Herba Girardiniae Palmatae, with all herbal medicine.Can adopt the whole year, using fresh herb or dry.Nature and flavor hardship, suffering, cold.Poisonous.Function cures mainly eliminates the phlegm, dampness removing, detoxifcation.Be used for cough with copious phlegm, edema.
Radix Glycyrrhizae is the root and rhizome of glycyrrhizic legume Glycyrrhiza urlensis Fish. Glycyrrhiza inflata Bat. G.Glabra L.Contain triterpene soap building site glycyrrhizic acid, i.e. glycyrrhizin, enoxolone.Still contain liquiritin, mannitol, malic acid, agedoite, volatile oil, estrogenic chemicals etc.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm is by spleen stomach function regulating, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, deficiency of QI in middle-JIAO, shortness of breath and fatigue, anorexia and loose stool, cough, asthma, skin sore, gastral cavity abdomen contraction is anxious has a pain etc.
Preparation of pharmaceutical compositions process using wet granulation of the present invention or dry granulation.Wherein said wet granulation is that principal agent and adjuvant are crossed 100 mesh sieves respectively, fully mixes, and takes by weighing the recipe quantity adjuvant then and fully mixes with principal agent.Add binding agent system soft material again, 20 mesh sieves are granulated, 55 ℃ of dryings, 18 mesh sieve granulate.Add the even tabletting of mix lubricant at last.Wherein said dry granulation is meant crosses 100 mesh sieves respectively with principal agent and adjuvant, fully mixes, and adopts the roll squeezer cake of press, and 18 mesh sieve granulate are crossed in the agent of reuse granulate, add the even tabletting of mix lubricant or encapsulated at last.
Compositions of the present invention through pharmacodynamic experiment further proof alleviate aspect the symptoms such as dyspnea that cause because of airway obstructive diseases such as bronchial asthma, chronic bronchitis and emphysema by name with commodity: the disclosed therapeutic effect of compound oral solution of Flxol is suitable, and therapeutic alliance has the obvious synergistic effect.500 routine chronic bronchitis asthmas are treated 3-5 the course of treatment through " compositions of the present invention ", and be 1 month each course of treatment, 438 examples are arranged effectively, do not cough, do not breathe heavily, have no interest, and total effective rate is 87.60%.
To use compositions of the present invention to be applied to clinical model case below:
(1) Tianjin patient Zhang
Excessively suffered from cold because of heavy rain is drenching in 30 years old, and cause more than the fever 39oC that it is big to cough, tell the yellow sputum amount, fishy smell is arranged, dyspnea with suffocation, bad giving vent to anger can not be put down for sleeping inly, is acute bronchitis companion pneumonia through the film making check result, and the recovery from illness in month of being in hospital is left hospital.In this year because of repeated cold, the asthma companion coughs up thick sputum during outbreak, increases the weight of gradually and with dyspnea, and is uncomfortable in chest, and expectorant is thick to be difficult for expectoration.Two lungs are covered with liver hello sound, bubble and wheezing sound, and exhaling prolongs the X radiodiagnosis x fully, emphysema, lung cyst, pulmonary belb, bronchodilator treatment narration, through antiinflammatory, antiinflammatory, anti-asthmatic, oral present composition tablet is after 1 course of treatment, asthma takes a turn for the better, it is flat that one wheat harvesting period is coughed Zhichuan, and health is strong, after obeying 3 courses of treatment, cough, breathe heavily, expectorant all eliminates, asthma is recurrence not.
(2) Zhejiang patient Liu is 18 years old
2 years old half because of suffering from an inflammation of the lungs cough with asthma so far, throughout the year or climate change all send out asthma, cough during morbidity, expectorant Huang and thickness, very then asthmoid respiration difficulty, night sweat poor appetite, constipation with dry stool.Through only controlling symptoms, the easily recurrence temporarily of clothes Western medicine.Took present composition tablet 3 days, and only showed effect once, promptly take an evident turn for the better next day.The night sweat number of times reduces, the apnea difficulty, and the expectorant complexion changed is yellowish and rare, appetite is gradually good, and it is soft to defecate, and two pulmonary respiration sounds are coarse, do not hear and wheezing sound, after continue to take a period of time asthma not, no night sweat, appetite increases, and does not have other any discomfort sensation, normal pulse is slow strong, the light red tongue tongue is red, and thin white, two pulmonary respiration sounds are no abnormal.Treated again one month, to consolidate curative effect.Follow up a case by regular visits to, as ordinary person.
(3) Harbin patient Zhu
56 years old, suffer from chronic bronchitis and merge nearly 25 years of emphysema, often play cough morning, cough up phlegm, the frothy sputum that is white in color, amount is many, and how because of the above sx of flu of suffering from cold, the companion slightly pants nearly one, two year concurrent emphysema.Once be in hospital repeatedly, and gave pre-anti-infective therapy, and used Drug therapys such as clorprenaline, aminophylline, hormone, symptom alleviated at that time, outbreak repeatedly after the drug withdrawal.After take present composition sheet and treat a week than preceding improvement, asthma still exists, outbreak repeatedly, the time heavy when light.In two week of treatment, the emphysema symptom makes moderate progress than before through the film making check, and attack times obviously reduces.Get back to the rural area now. continue to take consolidation, fully recover! Health is good.
The specific embodiment
The present invention is described further below in conjunction with embodiment, and embodiment only is indicative content, means that never it limits the scope of the invention by any way.
Embodiment 1
The preparation of Chinese medicine extract: with Corm Eleocharitis 10g, Radix Astragali 20g, Radix Codonopsis 10g, Sedum spectabile Boreau 50g, Radix Glycyrrhizae 20g, with second alcohol and water reflux, extract, 2 times, each 3 hours, each with 1000ml ethanol and 600ml backflow, filtrate is condensed into extractum, adds 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, are concentrated into to do after each 250ml, extract filter and merge to obtain extract.
Embodiment 2
The preparation of Chinese medicine extract: with Corm Eleocharitis 15g, Radix Astragali 25g, Radix Codonopsis 20g, Sedum spectabile Boreau 30g, Radix Glycyrrhizae 15g, with second alcohol and water reflux, extract, 2 times, each 3 hours, each with 1000ml ethanol and 600ml backflow, filtrate is condensed into extractum, adds 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, are concentrated into to do after each 250ml, extract filter and merge to obtain extract.
Embodiment 3
The preparation of Chinese medicine extract: with Corm Eleocharitis 30g, Radix Astragali 20g, Radix Codonopsis 50g, Sedum spectabile Boreau 20g, Radix Glycyrrhizae 15g, with second alcohol and water reflux, extract, 2 times, each 3 hours, each with 1000ml ethanol and 600ml backflow, filtrate is condensed into extractum, adds 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, are concentrated into to do after each 250ml, extract filter and merge to obtain extract.
Embodiment 4
Corm Eleocharitis 25g, Radix Astragali 20g, Radix Codonopsis 10g, Sedum spectabile Boreau 30g, Radix Glycyrrhizae 16g second alcohol and water reflux, extract, 2 times, each 3 hours, each with 1000ml ethanol and 600ml backflow, filtrate is condensed into extractum, add 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, be concentrated into after each 250ml, extract filter and merge to do and obtain extract.
Example 5:
Ambroxol hydrochloride 2.0g
Chinese medicine extract 7.5g
Xylitol 8.0g
Starch 2.0g
Polyvidone 1.0g
Carboxymethyl starch sodium 1.0g
Magnesium stearate qs
Principal agent and adjuvant are crossed 100 mesh sieves respectively, fully mix, take by weighing the recipe quantity adjuvant then and fully mix with principal agent.Add starch slurry system soft material again, 20 mesh sieves are granulated, 55 ℃ of dryings, 18 mesh sieve granulate.Add the even tabletting of mix lubricant at last.
Example 6 (dispersible tablet) (100 amounts)
Ambroxol hydrochloride 3.5g
Chinese medicine extract 2.0g
Xylitol 6.0g
Microcrystalline Cellulose 1.0g
Carboxymethyl starch sodium 1.5g
2% hypromellose qs
Silicon dioxide qs
Principal agent and adjuvant are crossed 100 mesh sieves respectively, fully mix, take by weighing the recipe quantity adjuvant then and fully mix with principal agent.Add binding agent system soft material again, 20 mesh sieves are granulated, 55 ℃ of dryings, 18 mesh sieve granulate.Add lubricant and remaining carboxymethylstach sodium mix homogeneously tabletting at last.
Example 7:(oral cavity disintegration tablet) (100 amount)
Ambroxol hydrochloride 7.5g
Chinese medicine extract 10g
Xylitol 4.5g
Microcrystalline Cellulose 2.0g
Cross-linking sodium carboxymethyl cellulose, 1.0g
Magnesium stearate qs
Silicon dioxide qs
Principal agent and adjuvant are crossed 100 mesh sieves respectively, fully mix, adopt the roll squeezer cake of press, 18 mesh sieve granulate are crossed in the agent of reuse granulate, add the even tabletting of mix lubricant at last.
Although more than the present invention done detailed description in conjunction with its special embodiment; but clearly still can make various changes and improvements concerning the skilled people in present technique field, these can not depart from the spirit and the protection domain of claim of the present invention.
Claims (8)
1, a kind of pharmaceutical composition for the treatment of chronic bronchitis and asthma is characterized in that it is made up of ambroxol hydrochloride and Chinese medicine extract: wherein ambroxol hydrochloride 5-20mg, Corm Eleocharitis 10-30g, Radix Astragali 10-20g, Radix Codonopsis 10-50g, Sedum spectabile Boreau 20-50g, Radix Glycyrrhizae 6-20g, pharmaceutic adjuvant are an amount of.
2, pharmaceutical composition as claimed in claim 1, the ratio of weight and number that it is characterized in that described ambroxol hydrochloride and Chinese medicine extract is 1:5-100.
3, pharmaceutical composition as claimed in claim 1 is characterized in that every single dose medicine carrying content of described ambroxol-hydrochloride-containing and Chinese medicine extract is 2:7.5-12:30mg.
4, as the described pharmaceutical composition of claim 1-3, Chinese medicine extract wherein is with Corm Eleocharitis 100-30g, Radix Astragali 10-20g, Radix Codonopsis 10-50g, Sedum spectabile Boreau 20-50g, Radix Glycyrrhizae 6-20g, with second alcohol and water reflux, extract, 2 times, each 3-10 hour, reflux with 1000ml ethanol and 600ml at every turn, filtrate is condensed into extractum, add 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, be concentrated into after each 250ml, extract filter and merge to do and obtain extract.
5, pharmaceutical composition as claimed in claim 1 is characterized in that described compositions comprises: conventional tablet, dispersible tablet, oral cavity disintegration tablet, effervescent tablet, chewable tablet, enteric coatel tablets, capsule, granule or enteric coated capsule.
6, pharmaceutical composition as claimed in claim 1 is characterized in that described pharmaceutic adjuvant adjuvant comprises: filler, binding agent, disintegrating agent, lubricant, correctives or aromatic.
7, oral solid formulation according to claim 5 is characterized in that described filler comprises: xylitol, dextrin, starch, pregelatinized Starch, mannitol or microcrystalline Cellulose; Described binding agent comprises starch, polyvidone, hypromellose, hyprolose, Polyethylene Glycol, medicinal alcohol or water; Described disintegrating agent comprises starch, low-substituted hydroxypropyl cellulose or carmethose.
8, oral solid formulation according to claim 5 is characterized in that described lubricant comprises Pulvis Talci, magnesium stearate, Polyethylene Glycol-4000 or Polyethylene Glycol-6000; Described correctives comprises sucrose, sorbitol, saccharin sodium or maltose alcohol; Described aromatic comprises: Herba Menthae or Oleum Cinnamomi; Artificial fragrant spermatophore is drawn together Fructus Citri tangerinae essence, flavoring banana essence or Fructus Citri Limoniae essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101505408A CN101450157A (en) | 2007-11-28 | 2007-11-28 | Medicine composition for treating chronic bronchitis and asthma |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101505408A CN101450157A (en) | 2007-11-28 | 2007-11-28 | Medicine composition for treating chronic bronchitis and asthma |
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| CN101450157A true CN101450157A (en) | 2009-06-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2007101505408A Pending CN101450157A (en) | 2007-11-28 | 2007-11-28 | Medicine composition for treating chronic bronchitis and asthma |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214058A (en) * | 2015-11-03 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of Chinese medicine composition for the treatment of asthma |
| CN105497364A (en) * | 2016-01-03 | 2016-04-20 | 岑溪市坤发液体燃烧炉具有限公司 | Traditional Chinese medicine formula for treating bronchitic asthma |
-
2007
- 2007-11-28 CN CNA2007101505408A patent/CN101450157A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214058A (en) * | 2015-11-03 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of Chinese medicine composition for the treatment of asthma |
| CN105497364A (en) * | 2016-01-03 | 2016-04-20 | 岑溪市坤发液体燃烧炉具有限公司 | Traditional Chinese medicine formula for treating bronchitic asthma |
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Open date: 20090610 |