CN101449970A - Bioelectric amplifier - Google Patents
Bioelectric amplifier Download PDFInfo
- Publication number
- CN101449970A CN101449970A CN 200810154631 CN200810154631A CN101449970A CN 101449970 A CN101449970 A CN 101449970A CN 200810154631 CN200810154631 CN 200810154631 CN 200810154631 A CN200810154631 A CN 200810154631A CN 101449970 A CN101449970 A CN 101449970A
- Authority
- CN
- China
- Prior art keywords
- amplifier
- signal
- bioelectric
- input
- frequency signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005070 sampling Methods 0.000 claims abstract description 8
- 238000012545 processing Methods 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000003990 capacitor Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Images
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Amplifiers (AREA)
Abstract
The invention discloses a bioelectric amplifier comprising an amplifier, an input end of the amplifier is provided with a bioelectric signal to be measured input by an electrode contact resistance, and is also provided with a high-frequency signal input by a resistance, the bioelectric signal to be measured together with the high-frequency signal enter into an analogue-to-digital converter to perform analog-to-digital conversion after passing through the amplifier and a low-pass filter in turn, then the electrode contact resistance is calculated by a processing unit and the bioelectric signal to be measured is obtained by sampling. The processing unit is a microprocessor or a microcontroller; the high-frequency signal is a differential high-frequency signal, the amplifier is a differential amplifier. The invention improves the accuracy of the signal, reduces the requirement for the amplifier gain, further improves the system performance and reduces system signal-noise ratio. The circuit is simple, the dynamic range is large, the input impedance is high, without debugging, the manufacturability is good, the performance and the function of the circuit are improved and the cost and the manufacturability requirement of the cost are reduced.
Description
Technical field
The present invention relates to a kind of electric amplifier.Particularly relate to the bioelectric amplifier that a kind of circuit is simple, performance is high, function is strong.
Background technology
Bioelectric detection has important use and is worth in medical research and clinical diagnosis, existing many bio electricity detecting instruments are widely used clinically, as electrocardiogram machine, electroencephalograph or the like.But because bioelectrical signals is faint, usually have various serious interfering signals again, many people are still in the research of detection method of carrying out bioelectrical signals and circuit.People such as Liu Song have proposed a kind of monitor ecg amplifier (health care equipment the 2nd phase of .1995,3～6), (High-quality recording of bio-electric events.Med.﹠amp such as A.C.Metting Van Riji; Bio.Eng.﹠amp; Comput., 1990, (Rapid recoveryphysiological preamplifier without AC coupling capacitor.Med.﹠amp such as 28:389-397, D.W.McRobbie; Bio.Eng.﹠amp; Comput., 1990, (I.A.Dotsinsky, et al., Multi-channel DC amplifierfor a microprocessor electrocardiograph.Med.﹠amp such as 28:198-200; Bio.Eng.﹠amp; Comput., 1991,29:324-329) design of multiple bioelectrical signals detecting amplifier or circuit has been proposed also.Li Gangs etc. have proposed multiple bioelectric amplifier (a kind of design of low-noise preamplifier, Chinese medical apparatus magazine, the 13rd the 1st phase of volume, 1989:18-19; 12 lead the research of D/AC feedback-type ecg signal amplifier, Chinese journal of scientific instrument, the 21st the 5th phase of volume, pp124-126, in October, 2000; High-performance multichannel bioelectric amplifier, University Of Tianjin's journal, the 33rd the 5th phase of volume, in JIUYUE, 2000; High common mode rejection ratio preamplifier, Chinese patent, application number: 02129065.2).
Above-mentioned various forms of bioelectric amplifier not only there being problems such as complex structure, manufacturability difference and performance be still not ideal enough in varying degrees, also exists sensitivity low, problems such as contact impedance that can not detecting electrode.
Summary of the invention
Technical problem to be solved by this invention is, overcomes above-mentioned the deficiencies in the prior art, provide that a kind of circuit is simple, dynamic range is big, input impedance is high, need not debugging, the bioelectric amplifier of good manufacturability, excellent performance.
The technical solution adopted in the present invention is: a kind of bioelectric amplifier, include amplifier, amplifier input terminal has tested bioelectrical signals by the input of electrode contact resistance, described amplifier input terminal also has the high-frequency signal by the resistance input, described tested bioelectrical signals and high-frequency signal are together successively by behind amplifier, the low pass filter, enter analog-digital converter and carry out analog digital conversion, treated again unit calculates the electrode contact resistance and sampling obtains tested bioelectrical signals.
Described processing unit is microprocessor or microcontroller.
Described high-frequency signal is differential high-frequency signal.
Described amplifier is a differential amplifier.
Bioelectric amplifier of the present invention applies a high-frequency signal in amplifier input terminal and has realized electrode contact resistance R
SMeasurement; Utilize same high-frequency signal to realize over-sampling to signal, so improve signal precision, reduced the requirement of pair amplifier gain, further improved the performance of system and reduced the signal to noise ratio of system.The present invention realizes not only that circuit is simple, dynamic range is big, input impedance is high, need not debugging, good manufacturability, excellent performance; And combine oversampling technique and electrode impedance detection technique dexterously, and improved the performance and the function that has strengthened circuit of circuit, reduced circuit cost and manufacturability requirement.
Description of drawings
Fig. 1 is that the system of bioelectric amplifier of the present invention constitutes block diagram;
Fig. 2 is the sketch map of the first embodiment of the present invention;
Fig. 3 is the sketch map of the second embodiment of the present invention.
The specific embodiment
Below in conjunction with embodiment and accompanying drawing bioelectric amplifier of the present invention is made a detailed description.
As shown in Figure 1, bioelectric amplifier of the present invention includes amplifier A, and the input of amplifier A is by electrode contact resistance R
SInput has tested bioelectrical signals V
S, the input of described amplifier A passes through resistance R in addition
fThe high-frequency signal V of input
f, described tested bioelectrical signals V
SWith high-frequency signal V
fSuccessively by behind amplifier A, the low pass filter RC, enter analog-digital converter ADC and carry out analog digital conversion together, treated again unit U calculates electrode contact resistance R
SAnd sampling obtains tested bioelectrical signals V down
S
Processing unit U described in the present embodiment is microprocessor or microcontroller; Described high-frequency signal V
fIt is differential high-frequency signal; Described amplifier A is a differential amplifier.
Bioelectric amplifier of the present invention applies a high-frequency signal V at the input of amplifier A by a resistance R _ f
f, V
fFrequency equal bioelectric sample frequency.
What on the one hand, amplifier A input obtained is resistance R
fWith electrode contact resistance R
SDividing potential drop V
fValue, after this signal amplified by amplifier A, the frequency overlapped-resistable filter that constitutes by RC network entered analog-digital converter ADC and changes again, because high-frequency signal V
fAmplitude and frequency much larger than tested bioelectrical signals V
S, microprocessor or microcontroller obtain can calculating electrode contact resistance R behind this signal
SAnd have enough precision.
On the other hand, tested bioelectrical signals V
SSame through resistance R
fWith electrode contact resistance R
SDividing potential drop is carried out signal through amplifier A and is amplified, and the frequency overlapped-resistable filter that RC network constitutes enters analog-digital converter ADC and changes, and microprocessor or microcontroller obtain can removing the high-frequency signal V that sneaks in this signal fully by following sample process behind this signal
fAnd sample process (over-sampling) can increase substantially precision down, and reduces the requirement of pair amplifier gain.
Fig. 2 is the sketch map of the first embodiment of the present invention.
As shown in Figure 2, bioelectric amplifier comprises two high-frequency signals (source) V
F1And V
F2, they also pass through resistance R respectively at two formation differential waves
F1And R
F2Be applied to two inputs of amplifier A.On the one hand, V
F1And V
F2Be to pass through resistance R
F1And R
F2With tested bioelectrical signals internal resistance R
S1And R
S2Dividing potential drop is applied to the input of amplifier A, and the frequency overlapped-resistable filter that constitutes by RC network again after amplifying through amplifier enters analog-digital converter ADC and changes, because two high-frequency signals (source) V
F1And V
F2Amplitude and frequency much larger than tested bioelectrical signals V
S1And V
S2, microprocessor or microcontroller obtain can calculating tested bioelectrical signals internal resistance (electrode contact resistance) R behind this signal
S1And R
S2And have enough precision.
On the other hand, tested bioelectrical signals V
S1And V
S2Same through electrode contact resistance R
S1And R
S2With resistance R
F1And R
F2Dividing potential drop is carried out signal through amplifier A and is amplified, the frequency overlapped-resistable filter that RC network constitutes enters analog-digital converter ADC and changes, and microprocessor or microcontroller obtain can removing two high-frequency signals (source) V that sneaks in this signal fully by following sample process (i.e. all sampled points in each cycle all stack up) behind this signal
F1And V
F2And sample process (over-sampling) can increase substantially the precision of analog-digital converter ADC down, and reduces the requirement of pair amplifier gain.
In the present embodiment: amplifier A can adopt AD620, and analog-digital converter ADC can adopt AD7738.Microprocessor can adopt MSC8051.
Fig. 3 is the sketch map of the second embodiment of the present invention.
As shown in Figure 3, bioelectric amplifier comprises two high-frequency signals (source) V
F1And V
F2, they also pass through resistance R respectively at two formation differential waves
F1And R
F2Be applied to two inputs of amplifier.
Resistance R 3, capacitor C 1 and resistance R 4, capacitor C 2 constitute the low-pass filter circuit of two inputs respectively, and diode D1, D2 and diode D3, D4 constitute the holding circuit of two inputs of amplifier respectively.Amplifier A2, A3, resistance R 5, R6 and R7 constitute differential preamplifier in parallel, two differential outputs of differential preamplifier in parallel are input to by amplifier A4, A5 by the high pass filter that capacitor C 3, resistance R 8 and capacitor C 4, resistance R 9 constitute respectively, resistance R 10, R11 and R12 constitute differential post amplifier in parallel, and the output after amplifying through differential post amplifier in parallel is sent to analog-digital converter by the low-pass filter circuit that resistance R 13, R14 and capacitor C 5 constitute again.
Follower (amplifier) A1, resistance R 1 and R2 constitute the common-mode signal sample circuit, and its output is used to drive input low pass filter, the common port (being the place that links together of capacitor C 1 and C2, diode D1, D2 and D3, D4) of holding circuit and the common port (end that links together of resistance R 8 and R9) of high pass filter.Simultaneously, this common-mode signal drives signal Vor output through the inverting amplifier amplification back that amplifier A6, resistance R 15, R16 and capacitor C 6 constitute as right lower limb.
On the one hand, two high-frequency signals (source) V
F1And V
F2Be to pass through resistance R
F1And R
F2With signal source internal resistance R
S1And R
S2(not drawing among Fig. 3) dividing potential drop is applied to the input of amplifier A, and the frequency overlapped-resistable filter that constitutes by RC network again after amplifying through amplifier enters analog-digital converter ADC (not drawing among Fig. 3) and changes, because two high-frequency signals (source) V
F1And V
F2Amplitude and frequency much larger than tested bioelectrical signals V
S1And V
S2(not drawing among Fig. 3), microprocessor or microcontroller obtain can calculating signal source internal resistance (electrode contact resistance) R behind this signal
S1And R
S2(not drawing among Fig. 3) also has enough precision.
On the other hand, tested bioelectrical signals V
S1And V
S2(not drawing among Fig. 3) passes through electrode contact resistance R equally
S1And R
S2With resistance R
F1And R
F2(not drawing among Fig. 3) dividing potential drop is carried out signal through amplifier A and is amplified, the frequency overlapped-resistable filter that R, C network constitute enters analog-digital converter ADC (not drawing among Fig. 3) and changes, and microprocessor or microcontroller (not drawing among Fig. 3) obtain can removing the V that sneaks in this signal fully by following sample process (i.e. all sampled points in each cycle all stack up) behind this signal
F1And V
F2And sample process (over-sampling) can increase substantially the precision of analog-digital converter ADC down, and reduces the requirement of pair amplifier gain.
In the present embodiment: amplifier A1～A6 can adopt LM324, and analog-digital converter ADC can adopt AD7738, and microprocessor can adopt MSC8051.
Claims (4)
1. a bioelectric amplifier includes amplifier (A), and the input of amplifier (A) is by electrode contact resistance (R
s) input has a tested bioelectrical signals (V
s), it is characterized in that the input of described amplifier (A) also has by resistance (R
f) input high-frequency signal (V
f), described tested bioelectrical signals (V
s) and high-frequency signal (V
t) together successively by behind amplifier (A), the low pass filter (RC), enter analog-digital converter (ADC) and carry out analog digital conversion, treated again unit (U) calculates electrode contact resistance (R
s) also sampling obtains tested bioelectrical signals (V
s).
2. bioelectric amplifier according to claim 1 is characterized in that, described processing unit (U) is microprocessor or microcontroller.
3. bioelectric amplifier according to claim 1 is characterized in that, described high-frequency signal (V
f) be differential high-frequency signal.
4. bioelectric amplifier according to claim 1 is characterized in that, described amplifier (A) is a differential amplifier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810154631 CN101449970B (en) | 2008-12-29 | 2008-12-29 | Bioelectric amplifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810154631 CN101449970B (en) | 2008-12-29 | 2008-12-29 | Bioelectric amplifier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101449970A true CN101449970A (en) | 2009-06-10 |
| CN101449970B CN101449970B (en) | 2013-01-16 |
Family
ID=40732582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810154631 Expired - Fee Related CN101449970B (en) | 2008-12-29 | 2008-12-29 | Bioelectric amplifier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101449970B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579033A (en) * | 2012-02-09 | 2012-07-18 | 天津大学 | Bioelectrical front-mounted amplifier driven by constant current source and control method for bioelectrical front-mounted amplifier |
| CN102968957A (en) * | 2011-08-30 | 2013-03-13 | 联咏科技股份有限公司 | A light-emitting diode (led) device, and an led driving circuit and method |
| CN103149438A (en) * | 2013-01-24 | 2013-06-12 | 上海帝仪科技有限公司 | Brain electrical contacting resistance detection method and device |
| CN103705230A (en) * | 2014-01-14 | 2014-04-09 | 南京大学 | Pre-stage circuit in bioelectricity detection |
| CN104783776A (en) * | 2015-04-23 | 2015-07-22 | 天津大学 | Single-channel collection device and method for modulating multi-channel signals through bioelectricity and orthogonal sine waves |
| CN104838229A (en) * | 2012-10-23 | 2015-08-12 | 通用电气公司 | Ultrasonic measurement apparatus and method |
| CN110115575A (en) * | 2019-06-24 | 2019-08-13 | 首都医科大学附属北京中医医院 | A kind of bioelectric amplifier based on electrophysiological technique |
| CN110393526A (en) * | 2019-08-16 | 2019-11-01 | 北京师范大学 | A kind of high frequency feeble computer signals amplification acquisition system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299640C (en) * | 2004-11-18 | 2007-02-14 | 天津大学 | Bioelectrical detection circuit |
| CN2753289Y (en) * | 2004-11-22 | 2006-01-25 | 中国科学院心理研究所 | Electroencephalo signal amplifier |
-
2008
- 2008-12-29 CN CN 200810154631 patent/CN101449970B/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102968957A (en) * | 2011-08-30 | 2013-03-13 | 联咏科技股份有限公司 | A light-emitting diode (led) device, and an led driving circuit and method |
| CN102968957B (en) * | 2011-08-30 | 2015-08-05 | 联咏科技股份有限公司 | Light-emitting diode assembly, LED driving circuit and method |
| CN102579033A (en) * | 2012-02-09 | 2012-07-18 | 天津大学 | Bioelectrical front-mounted amplifier driven by constant current source and control method for bioelectrical front-mounted amplifier |
| CN102579033B (en) * | 2012-02-09 | 2013-11-13 | 天津大学 | Bioelectrical front-mounted amplifier driven by constant current source and control method for bioelectrical front-mounted amplifier |
| CN104838229A (en) * | 2012-10-23 | 2015-08-12 | 通用电气公司 | Ultrasonic measurement apparatus and method |
| CN104838229B (en) * | 2012-10-23 | 2017-08-15 | 通用电气公司 | Ultrasonic measurement apparatus and method |
| CN103149438A (en) * | 2013-01-24 | 2013-06-12 | 上海帝仪科技有限公司 | Brain electrical contacting resistance detection method and device |
| CN103705230A (en) * | 2014-01-14 | 2014-04-09 | 南京大学 | Pre-stage circuit in bioelectricity detection |
| CN103705230B (en) * | 2014-01-14 | 2017-02-15 | 南京大学 | Pre-stage circuit in bioelectricity detection |
| CN104783776A (en) * | 2015-04-23 | 2015-07-22 | 天津大学 | Single-channel collection device and method for modulating multi-channel signals through bioelectricity and orthogonal sine waves |
| CN110115575A (en) * | 2019-06-24 | 2019-08-13 | 首都医科大学附属北京中医医院 | A kind of bioelectric amplifier based on electrophysiological technique |
| CN110393526A (en) * | 2019-08-16 | 2019-11-01 | 北京师范大学 | A kind of high frequency feeble computer signals amplification acquisition system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101449970B (en) | 2013-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101449970B (en) | Bioelectric amplifier | |
| Gifari et al. | Design of ECG Homecare: 12-lead ECG acquisition using single channel ECG device developed on AD8232 analog front end | |
| Merletti et al. | Detection and conditioning of surface EMG signals | |
| Yazicioglu et al. | A 30$\mu $ W Analog Signal Processor ASIC for Portable Biopotential Signal Monitoring | |
| US8903479B2 (en) | Real time QRS duration measurement in electrocardiogram | |
| CN102334981B (en) | Multiplex humpulse wave signal acquisition system | |
| CN110786848B (en) | Single-channel acquisition amplifier for multiple physiological parameter signals | |
| CN104783781B (en) | Low distortion ecg signal acquiring process circuit and electrocardiogram acquisition equipment | |
| Nyni et al. | Wireless health monitoring system for ECG, EMG and EEG detecting | |
| CN102579033B (en) | Bioelectrical front-mounted amplifier driven by constant current source and control method for bioelectrical front-mounted amplifier | |
| CN1299640C (en) | Bioelectrical detection circuit | |
| Szakacs-Simon et al. | Signal conditioning techniques for health monitoring devices | |
| Zhu et al. | A multi-channel ECG acquisition system based on FPGA | |
| Wu et al. | An ECG extraction and reconstruction system with dynamic EMG filtering implemented on an ARM chip | |
| CN104706344A (en) | Electrocardiosignal measurement collecting system | |
| CN115192005A (en) | Portable electrocardiogram and seismogram combined acquisition system and data processing method | |
| CN204654930U (en) | The superelevation common mode rejection circuit of ecg signal acquiring and electrocardiogram acquisition equipment | |
| Jinchuang et al. | Design and implementation of multi-parameter portable biological information measurement system | |
| CN106388808B (en) | Novel multichannel electrocardiogram acquisition scheme | |
| CN102499671B (en) | Ventricular repolarization high-frequency wave double-limb electrode detecting device | |
| Li et al. | Mechanism and Acquisition in Portable ECG Monitors | |
| CN204600459U (en) | Low distortion ecg signal acquiring treatment circuit and electrocardiogram acquisition equipment | |
| CN205697751U (en) | Bioelectric signal measuring apparatus | |
| Zhou et al. | Design of a sEMG Signal Acquisition Instrument for Physical Rehabilitation Training | |
| CN214434244U (en) | Lead electrode plate for wireless data transmission type electrocardiogram measuring system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130116 |