CN101417985A - Method for synthesizing 2-amino thizaoline - Google Patents
Method for synthesizing 2-amino thizaoline Download PDFInfo
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- CN101417985A CN101417985A CNA2008100798980A CN200810079898A CN101417985A CN 101417985 A CN101417985 A CN 101417985A CN A2008100798980 A CNA2008100798980 A CN A2008100798980A CN 200810079898 A CN200810079898 A CN 200810079898A CN 101417985 A CN101417985 A CN 101417985A
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- Prior art keywords
- thiazolamine
- synthetic method
- reaction
- thanomin
- hours
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- Thiazole And Isothizaole Compounds (AREA)
Abstract
Description
Claims (7)
- The synthetic method of 1 one kinds of thiazolamine quinolines, be under 40~75 ℃, thanomin and sulfur oxychloride directly to be carried out chlorination generation 2-chloroethyl amine hydrochloride in organic solvent, under 70~100 ℃, carry out annulation again and generate the thiazolamine quinoline with 2-chloroethyl amine hydrochloride and thiocarbamide.
- The synthetic method of 2 thiazolamine quinolines according to claim 1 is characterized in that in the described chlorination, and thanomin is 1: 1.1~1.5 with the amount of substance ratio of sulfur oxychloride.
- The synthetic method of 3 thiazolamine quinolines according to claim 1 is characterized in that in the described annulation, and the 2-chloroethyl amine hydrochloride is 1: 2.5~3 with the amount of substance ratio of thiocarbamide.
- The synthetic method of 4 thiazolamine quinolines according to claim 1, the reaction times that it is characterized in that described chlorination is 10~15 hours.
- The synthetic method of 5 thiazolamine quinolines according to claim 1, the reaction times that it is characterized in that described annulation is 20~24 hours.
- The synthetic method of 6 thiazolamine quinolines according to claim 1 is characterized in that described organic solvent is a kind of in methylene dichloride, chloroform, toluene, dimethylbenzene, orthodichlorobenzene, ethyl acetate, the ethylene dichloride.
- The synthetic method of 7 thiazolamine quinolines according to claim 6, the consumption that it is characterized in that described organic solvent are 3~10 times of thanomin quality.
Priority Applications (1)
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CN2008100798980A CN101417985B (en) | 2008-11-24 | 2008-11-24 | Method for synthesizing 2-amino thizaoline |
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CN2008100798980A CN101417985B (en) | 2008-11-24 | 2008-11-24 | Method for synthesizing 2-amino thizaoline |
Publications (2)
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CN101417985A true CN101417985A (en) | 2009-04-29 |
CN101417985B CN101417985B (en) | 2011-02-09 |
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CN2008100798980A Active CN101417985B (en) | 2008-11-24 | 2008-11-24 | Method for synthesizing 2-amino thizaoline |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102633702A (en) * | 2012-03-22 | 2012-08-15 | 广州九益生物技术有限公司 | Beta-amino ethyl thiosulfuric acid and synthesis method thereof |
CN111574381A (en) * | 2020-04-17 | 2020-08-25 | 杭州盛弗泰新材料科技有限公司 | Method for preparing 2-chloroethylamine hydrochloride |
CN116554120A (en) * | 2023-07-10 | 2023-08-08 | 山东国邦药业有限公司 | Preparation method of 2-amino-2-thiazoline |
-
2008
- 2008-11-24 CN CN2008100798980A patent/CN101417985B/en active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102633702A (en) * | 2012-03-22 | 2012-08-15 | 广州九益生物技术有限公司 | Beta-amino ethyl thiosulfuric acid and synthesis method thereof |
CN111574381A (en) * | 2020-04-17 | 2020-08-25 | 杭州盛弗泰新材料科技有限公司 | Method for preparing 2-chloroethylamine hydrochloride |
CN111574381B (en) * | 2020-04-17 | 2023-01-10 | 杭州盛弗泰新材料科技有限公司 | Method for preparing 2-chloroethylamine hydrochloride |
CN116554120A (en) * | 2023-07-10 | 2023-08-08 | 山东国邦药业有限公司 | Preparation method of 2-amino-2-thiazoline |
CN116554120B (en) * | 2023-07-10 | 2023-10-20 | 山东国邦药业有限公司 | Preparation method of 2-amino-2-thiazoline |
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CN101417985B (en) | 2011-02-09 |
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Inventor after: Su Wei Inventor after: Chen Wancheng Inventor after: Gao Zhiwei Inventor after: Chu Piming Inventor after: Su Binlin Inventor after: Kang Futang Inventor before: Su Binlin Inventor before: Chen Wancheng Inventor before: Gao Zhiwei Inventor before: Chu Piming Inventor before: Su Wei Inventor before: Kang Futang |
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CP01 | Change in the name or title of a patent holder | ||
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Address after: 030500 Shanxi province Jiaocheng Cross Ridge Road from the 307 National Road 1000 meters Patentee after: Shanxi xintianyuan Pharmaceutical Co. Ltd. Address before: 030500 Shanxi province Jiaocheng Cross Ridge Road from the 307 National Road 1000 meters Patentee before: Shanxi Xintianyuan Pharm. & Chem. Co., Ltd. |