CN101411701A

CN101411701A - Vitamin C microcapsule formulation and preparation method thereof

Info

Publication number: CN101411701A
Application number: CNA200710028486XA
Authority: CN
Inventors: 周玉岩; 逯佩凤; 杨龙飞
Original assignee: HAINACHUAN PHARMACEUTICAL CO Ltd FOSHAN CITY
Current assignee: HAINACHUAN PHARMACEUTICAL CO Ltd FOSHAN CITY
Priority date: 2007-06-08
Filing date: 2007-06-08
Publication date: 2009-04-22

Abstract

The invention relates to the field of feed additives, and provides a novel vitamin C preparation which is defined as a micro-capsule preparation according to usage characteristics, dissolution rate in stomach and intestine, stability and appearance shaping for effectively improving the use effect of vitamin C in cultivation. Meanwhile, the invention also provides a novel process for producing a sustained-release micro-capsule. The process has great improvement in safety, energy conservation, reduction of materials consumption, production benefit and other aspects.

Description

Vitamin C microcapsule formulation and preparation method thereof

Technical field

The present invention relates to the ascorbic a kind of new formulation that in poultry and aquatic feeds, adds and the processing technique of producing this preparation.Specifically, use one or more sustained-release and controlled release macromolecular materials and vitamin C to be prepared into a kind of microcapsule formulation efficiently, and the industrialized preparing process of producing this microcapsule formulation.

Background technology

Vitamin C is widely used in the animal feed as feed additive, but there is the factor of three aspects in the vitamin C of ordinary preparation and causes its instability.

The first, the instability of physicochemical properties own.Because vitamin C has strong reproducibility, oxidation by air easily under alkalescence or acid condition, chemical factors such as ultraviolet, heating and metal ion have more been aggravated ascorbic destruction.

The second, the feedstuff course of processing causes instability.The processing of feed granules material will be passed through high temperature, high pressure, high humidity, and these factors have more been aggravated ascorbic destruction.

The second, ascorbic instability during feedstuff uses.Particularly ascorbic consumption is more in the aquatic feeds, because aquatic feeds will soak in water, general common Vitamin C preparation is easy to soluble in water or destroyed.Vitamin C also is easy to loss of activity in packing, the storage process in addition.

Above-mentioned several situation generally causes vitamin C addition in feedstuff can reach actual poultry, aquatic products theory demands amount 4 to 5 times, has caused ascorbic waste, the rising of feed cost, even also caused potential pollution.

Vitamin C preparation has several forms both at home and abroad now:

The first, common crystal vitamin C;

The second, peplos (coating, bag quilt) Vitamin C preparation;

The 3rd, vitamin C polyphosphoric acids fat.

In people's medicine, also have Cevalin, vitamin C tablet, vitamin C pill, vitamin C effervescent tablet or the like in addition, but the dosage form in the feedstuff because of cost reason generally have only above-mentioned three kinds

First kind of common crystal vitamin C, though low price, large usage quantity, effect relatively poor (visible " three kinds of Vc products are to the research of Ctenopharyngodon idellus fingerling growth effect ", Shi Wenlei etc., Oceanography Institute Of Zhejiang's journal 2001,9).

Second kind of peplos (coating, bag by) Vitamin C preparation, used coating material is generally: ethyl cellulose, carboxymethyl cellulose, polypropylene, acroleic acid resin, or the like, and the synergist of part coated fertilizer is as diethyl phthalate etc.More than visible domestic patent 02103718.3, patent 200410061286.0, patent 03150440.X.

The processing technique that the production of this kind coated vitamin C is adopted is a fluid bed processing method (patent 02103718.3, patent 03150440.X) etc.So-called peplos, coating, bag quilt, basic conception is identical, naming method also comes from its processing technique, and the processor of therefore most of this series products all is earlier the vitamin C raw material to be granulated, and the coated fertilizer that will be dissolved in organic solvent afterwards again is sprayed on the surface of vitamin C granules.Because of its processing technique has also determined the higher of processing cost, the organic solvent that is used to dissolve coated fertilizer generally all is volatile, and all volatilizations in process of production are difficult to recyclingly, have also caused the rising of cost.In addition because the size of vitamin C granules in the first step course of processing, the inhomogeneities of shape etc. also can cause situations such as the complete or peplos rate of peplos is low, and then result of use is affected also.

The third vitamin C polyphosphoric acids fat is a kind of mode of protecting vitamin C best at present, is to generate with vitamin C and polyphosphate chemosynthesis, (visible patent 1651422A).Production cost height, course of reaction be difficult control etc. also, is its characteristics.

According to the situation of vitamin C market and production and processing, the invention provides a kind of and present being seen different completely Vitamin C preparation form and processing technique of market.Relevant therewith, the Vitamin C preparation form of being produced by this processing technique also is obviously to be different from other Vitamin C preparation product forms on the market, belongs to a kind of new dosage form.

Summary of the invention

The purpose of this invention is to provide a kind of new Vitamin C preparation form, belong to microcapsule formulation, is to be different from Vitamin C preparation in the present feed additive market.

Another object of the present invention provides the production method of producing this controlled-releasing microcapsule preparation.

Applied adjuvant has one or more mixing in hard ester acid, calcium stearate list glyceride, hard ester alcohol, saturated triglyceride, monoglyceride, paraffin, animal wax, vegetable wax, the fatty powder etc., configuration proportion is generally 50:50, according to user or market demands, configuration proportion can reach 40%-60% (in effective vitamin C).The extensive use in people's medicine of these adjuvants belongs to the safe adjuvant of no side effects.

A kind of new technology for preparing novel vitamin C microcapsule formulation is characterized in that it comprises the steps:

1. vitamin C raw material and adjuvant are prepared by compound method;

2. with adjuvant input batch can, heating is all melted adjuvant, stirs simultaneously;

3. will melt adjuvant and from change batch can, import material-compound tank, and the vitamin C raw material of accurately weighing input material-compound tank, shear agitation will be noted temperature control therebetween;

The material that 4. will prepare imports storage tank, the insulation heating;

5. start defeated material sprayer unit, with proportioned material spray granulation in the storage tank;

6. made finished particle is sieved the collection of sieving through cooling system and with the concussion of 24 orders-80 order.

This technology material temperature is 80 ℃-105 ℃; The stirring of material-compound tank is a shear agitation, and the time is 6-12 minute; Temperature in the storage tank is controlled at 80 ℃-100 ℃; Granulate the vitamin C microcapsule granule between preferred 24 orders-80 order at last by sprayer unit.

This art production process is fully closed production procedure and totally enclosed material-transporting system, reduces dust from flying and spillage of material, the total yield of products height, and product appearance is spherical in shape, and good fluidity more helps mixing, and with plain particles very big improvement is arranged relatively.

Description of drawings:

1, vitamin C microcapsule processing process figure:

See the Figure of description part:

1.. adjuvant

2.. the vitamin C raw material

3.. change batch can

4.. material-compound tank

5.. storage tank

6.. sprayer unit

7.. cooling system

8.. vibrosieve

The specific embodiment:

Example one

Select hard ester acid 225kg inputization batch can for use, be heated to 80 ℃, constantly stir, treat that adjuvant all melts; To melt hard ester acid and pump into material-compound tank from change batch can, accurately the vitamin C 100kg of weighing drops into material-compound tank simultaneously, shear agitation 10 minutes, and temperature will be controlled at 80 ℃ therebetween; The material that prepared is imported storage tank, and heating-up temperature to 80 ℃-100 ℃; Start defeated material sprayer unit, proportioned material in the storage tank is passed through spray granulation; Made finished particle is sieved the collection of sieving with the concussion of 24 orders-80 order.Obtain 313kg finished product vitamin C microcapsule formulation at last, particle diameter is at 200 μ m-700 μ m, and yield can reach 96%.

Example two

Select paraffin and hard ester acid 175kg (1:1) inputization batch can for use, be heated to 80 ℃, constantly stir, treat that adjuvant all melts; To melt adjuvant and pump into material-compound tank from change batch can, accurately the vitamin C 80kg of weighing drops into material-compound tank simultaneously, shear agitation 8 minutes, and temperature will be controlled at 80 ℃ therebetween; The material that prepared is imported storage tank, and heating-up temperature to 80 ℃-100 ℃; Start defeated material sprayer unit, proportioned material in the storage tank is granulated by spray chilling equipment; Made finished particle is sieved the collection of sieving with the concussion of 24 orders-80 order.Obtain 245kg finished product vitamin C controlled-releasing microcapsule preparation at last, particle diameter is at 200 μ m-700 μ m, and yield can reach 96%.

Example three

Select calcium stearate list glyceride and fatty powder 220kg (2:1) inputization batch can for use, be heated to 80 ℃, constantly stir, treat that adjuvant all melts; The adjuvant that has melted is pumped into material-compound tank from change batch can, accurately the vitamin C 100kg of weighing drops into material-compound tank simultaneously, shear agitation 8 minutes, and temperature will be controlled at 80 ℃ therebetween; The material that prepared is imported storage tank, and heating-up temperature to 80 ℃-100 ℃; Start defeated material sprayer unit, proportioned material in the storage tank is granulated by spray chilling equipment; Made finished particle is sieved the collection of sieving with the concussion of 24 orders-80 order.Obtain 303.5kg finished product vitamin C microcapsule formulation (50%) at last, particle diameter is at 200 μ m-700 μ m, and yield can reach 95%.

Claims

1: a kind of new technology for preparing novel vitamin C microcapsule formulation is characterized in that it comprises the steps:

1.. vitamin C raw material and adjuvant are prepared in compound method and ratio;

2.. with adjuvant input batch can, heating is all melted adjuvant, stirs simultaneously;

3.. will melt adjuvant and from change batch can, import material-compound tank, and the vitamin C raw material of accurately weighing input material-compound tank, shear agitation will be noted temperature control therebetween;

4.. the material that will prepare imports storage tank, the insulation heating;

5.. start defeated material sprayer unit, with proportioned material spray granulation in the storage tank;

6.. made finished particle is sieved the collection of sieving through cooling system and with the concussion of 24 orders-80 order.

2: according to right 1, processing step 2., heating-up temperature is 80 ℃-105 ℃;

3: according to right 1,3. processing step stirs and is the emulsify at a high speed shear agitation, and mixing time is 6-12 minute;

4: according to right 1, processing step 4., heating-up temperature is 80 ℃-100 ℃;

5: according to right 1, processing step 5., the sprayer unit that uses is Highspeedcentrifugingandsprayingdrier;

6: according to right 1, processing step 6., sieving is 24 orders-80 orders, size 700-200 μ m;

7: microcapsule provided by the present invention, the outward appearance spheroidal particle that is white in color, Diaspora Performance is good, and used adjuvant safety has no side effect to poultry.This microcapsule formulation is stable in water, can protect vitamin C to exempt from by pyritous destruction, and effectively discharges in the aquatic animal the intestines and stomach, guarantees that animal is to ascorbic picked-up;

8: according to right 7 requirements, its adjuvant has hard ester acid, calcium stearate list glyceride, hard ester alcohol, saturated triglyceride, monoglyceride, paraffin, animal wax, vegetable wax, fatty powder etc.;