CN101400378A

CN101400378A - Improving disinfection efficacy of lens care regimen for rigid gas permeable contact lenses

Info

Publication number: CN101400378A
Application number: CNA2007800090595A
Authority: CN
Inventors: 夏尔宁; J·C·萨拉莫内; D·M·安蒙; R·N·博拉兹亚尼
Original assignee: Bausch and Lomb Inc
Current assignee: Bausch and Lomb Inc
Priority date: 2006-01-20
Filing date: 2007-01-19
Publication date: 2009-04-01

Abstract

A rigid gas permeable lens care composition. The composition includes a disinfecting amount of at least one biguanide antimicrobial agent and a straight chain polyether surfactant based upon PEO-PPO-PEO, PPO-PEO-PPO and combinations thereof. In one embodiment, the straight chain polyether surfactant has an HLB value of less than or equal to 15 and an average molecular weight value of between about 5000 and 7000. Preferably, no rubbing is required to disinfect the rigid gas permeable contact lenses is required. Methods of making and using the same are also described.

Description

Improve the care method of the RGP of Disinfection Effect with eyeglass

Technical field

The present invention relates to a kind of hard air-permeable (RGP) contact lens disinfectant compositions and method of being used for.Particularly, the present invention relates to a kind of compositions and method that not needing to be used for the sterilization RGP contact lens of eyeglass wiping step.

Background technology

The contact lens of Shi Yonging is divided into three general kinds now: by the hard lenses that forms by acrylic ester polymerization, as the material by polymethyl methacrylate (PMMA) preparation; Hard air-permeable (RGP) eyeglass that forms by siloxanes (methyl) acrylate and fluorosilicone methacrylate; And the eyeglass of soft type such as gel, hydrogel.Because the eyeglass of hard and rigid type has low vapor diffusion and only absorbs the characteristic of a small amount of aqueous fluid, so they are lower with the bonded tendency of active component that is used for the contact lens conditioning liquid.On the contrary, the lens of soft type are higher with the bonded tendency of active component that is used for the contact lens conditioning liquid.Therefore, the solution that development is handled as soft type eyeglass is especially challenged, and no matter it is to be made by more traditional 2-hydroxyethyl meth acrylate (HEMA) copolymer, is still made by the newer siloxanes hydrogel material that contains.

In wearing the general process of contact lens, Tear Film and the fragment be made up of proteinic, butyrous, adipose and relevant organic substance have the tendency that deposits and be deposited in lens surface.The sedimental formation of many factor affecting, it comprises difference, lens materials, care regimen and the environment of patient to the patient.Usually, higher moisture ion optics material absorbs more protein than relatively low water content or nonionic lens materials.As the part of routine care scheme, must clean to remove Tear Film deposition and fragment contact lens.If the inappropriate deposit of removing, then the wettability of eyeglass and optical clarity will significantly descend, and may cause the wearer uncomfortable.

In addition, must be to contact lens be sterilized to kill the harmful microorganism that may exist or be grown on the eyeglass.The product of the sterilization eyeglass that some are most popular is a multipurpose solution, and it can be used for cleaning, sterilization and moistening contact lens, then it is directly embedded or is placed on the glasses, does not carry out rinsing.Apparently, the single solution that can be used for lens care is favourable.Yet such solution must be gentle especially to eye, because when eyeglass being embedded or is placed on the eyes, will be on eyeglass to small part solution, and so will directly contact with eye tissue.

Because multipurpose solution is designed to as wetting agent and is further designed to do not carry out rinsing and use, so it is essential that contact is a safety on the ophthalmology to this solution to eye.This has limited the cleaning agent that can be used in this solution and the type and the concentration of antimicrobial or biocide to a certain extent.For example, be understood that easily that biocide agent in the shampoo product or cleaning agent may be not suitable for ophthalmology and use.Work out on the one hand to greatest extent effectively and enough gentle on the other hand, so that ophthalmic is used not only safety, and comfortable prescription has been a challenge.

When employing comprised that traditional contact lens cleaning agent of multipurpose solution or disinfectant are handled contact lens, the lens wear person is manual wiping contact lens generally, usually between finger and the palm or between finger.Every day, the necessity of " wiping " contact lens increased time and effort that the daily nursing contact lens involves.Many contact lens wearers dislike the scheme that must implement, think that perhaps this is an inconvenience.Some wearers may neglect correct " wiping " method, and this may cause the uncomfortable or other problems of contact lens.If carry out overweightly sometimes, wiping may damage eyeglass, and this is easy to occur in the people who just begins lenses fitted especially.In the time can not replacing at once, this may be problematic.In addition, some wearers may neglect correct " rinsing " method, and this may cause the uncomfortable and other problem of contact lens.

For example, according to the requirement at Premarket Notification (510K) the Guidance Document of contact lens care product that food and drug administration (FDA) set up on May 1st, 1997, the contact lens solution of qualified conduct " chemical disinfection liquid " should carry out wiping just can satisfy the biocidal performance standard of eliminating representational antibacterial and fungus.The contact lens liquid certain claim of qualified conduct on the contrary, " chemical disinfection system " is by the wiping scheme of biocidal performance standard.Traditionally, be used to sterilize and moistening or be used to is sterilized, the multipurpose solution of cleaning and moistening is qualified as the chemical disinfection system, but be not as chemical disinfection liquid.

Conventional contact lens solution can depend on the wiping scheme, and it is not only for effective sterilization, and for effective cleaning.Therefore, opposite with " wiping and the rinsing " and/or the scheme of " wanting rinsing " that are used to clean without wiping, in order to work out the contact lens conditioning liquid that effective cleaning can be provided and need not wiping or rinse method, require it to have the cleaning effect of improvement and still enough gentle to the ophthalmic use.

GB 1,432, and 345 have proposed a kind of sanitizing composition that comprises polymeric biguanide and blended phosphate buffer.Yet the keratochromatosis value of the compositions that this patent proposed is 17% or more, is higher than far away the desirable value of patient's acceptance.

US 4,758,595 proposed a kind of comprise poly-(aminopropyl biguanide) (PAPB), be also referred to as poly-(hexamethylene biguan-ide) contact lens solution (PHMB), when combining with borate buffer, this solution has the effect of raising.When allegedly using with low concentration, sterilization that is proposed and listerine, in addition, it is said that it has hypotoxicity when with the soft contact lens with killing antibacterial and mycocidal activity.US4,758,595 point out, comprise PHMB and boratory compositions with about 1ppm or lower content commercialization in the many products that comprise multipurpose solution, for using with soft contact lens.

US 4,820, and 352 have proposed a kind of compositions that is used to clean and nurse one's health contact lens, and wherein main cleaning agent is the ethylenediamine of Special Category and the adduct of polyox-yethylene-polyoxypropylene block copolymer (having another name called the husky amine (poloxamine) in pool Lip river).The compositions that is proposed it is said essentially no zest, and the contact lens that suggestion is crossed with this solution-treated can directly embed ophthalmic.

U.S 5,209, and 865 have proposed a kind of contact lens conditioning liquid, and it comprises that HLB (hydrophile-lipophile balance value) respectively does for oneself 7 or the combination of husky amine in lower pool Lip river and poloxamer surfactants.Its suggestion can prepare the solution that forms even hydrophilic film on lens surface, and wherein protein may have very little affinity.

US 5,604,189 and US 5,773,396 have proposed a kind of compositions that is used to clean with the moistening contact lens, it comprises that (i) a kind of HLB is at least about 18 non-amine and contains polyoxyethylene compound, and (ii) the HLB that the contact lens deposit is had a cleaning action is for less than 18 surfactant and (iii) wetting agent.In another approach, suggestion can be with tyloxapol as the conventional surfactants in the multipurpose solution, and this surfactant it is said that the contact lens deposit is had cleaning action, and HLB is less than 18.

US 6,143, and 244 have proposed a kind of compositions of handling the method for contact lens and being used for such purposes.The method that proposes comprises uses the aqueous biguanide disinfectant solution that contains, and it comprises the buffer system that comprises phosphate and borate buffer mixture.Also proposed to be used for the method and composition of cleaning and disinfection contact lens simultaneously.

US 6,790, and 816 have proposed no wiped clean and antiseptic solution, it is said that it contains the antibacterial and the infiltration solute of effective dose.

US patent disclosure 2002/0141899 has proposed a kind of compositions of having used the sterilization contact lens of hydrogen peroxide and surfactant.

US patent disclosure 2003/0118472 has proposed the system and the method for a kind of sterilization and cleaning contact lens.The system that is proposed comprises uses iodide salt and hydrogen peroxide.Also proposed to exempt from wiping-exempt from rinse method.

US patent disclosure 2003/0153475 has proposed a kind of method of using the cleaning contact lens of trometamol, and advises unnecessary manual wiping.A kind of method that does not comprise manual rinse step has also been proposed.

US patent disclosure 2004/0185028 has proposed a kind of one or more ethanolamine buffer and biguanide disinfectants and one or more compositionss in order to the antimicrobial of sterilization contact lens purpose of comprising.

US applies for having proposed respectively for the 10/926th, 514 and 10/926, No. 504 adopting three alkanolamine alkoxides, N, N, N ¹, N ¹-four (hydroxyalkyl) diamidogen and N, N, N ¹, N ¹-four (hydroxy alkoxy base) diamidogen is the lens care liquid of buffer agent.

Obtain that a kind of the multipurpose contact lens solution that has a cleaning effectiveness of increase for the RGB eyeglass can be provided is desirable.Acquisition has the cleaning effectiveness of improvement for the RGP eyeglass, and keep simultaneously solution biocidal efficient and low to ocular tissue's toxicity be desirable equally.The multi-functional contact mirror solution low to eye tissue toxicity is provided, make solution is used to handle contact lens after, eyeglass can then be placed on the eyes, is further desirable and need not rinse solution from eyeglass.Still, more challenging is to obtain a kind of effective cleaning and disinfection that shows contact lens, particularly RGP eyeglass, and for acceptable performance does not need wiping or rinsing scheme or extrinsic ground or always require wiping and rinsing at least, this also is desirable.Such solution can be allowed at infiltration solution and/or after with described solution rinsing and rewetting, directly contact lens is placed on the eyes.

Summary of the invention

The present invention includes a kind of hard air-permeable lens care liquid.This lens care liquid comprises at least a biguanide antimicrobial of sterilization amount and based on the straight-chain polyether surfactant of PEO-PPO-PEO, PPO-PEO-PPO and combination thereof.Described lens care liquid can clean the hard air-permeable eyeglass under the situation of manually wiping or rinsing hard air-permeable eyeglass.

In one embodiment, the straight-chain polyether surfactant HLB value of hard air-permeable lens care is for being less than or equal to 15, and the mean molecule numerical quantity is about 5000-7000.

The chemical constitution of the straight-chain polyether surfactant of the hard air-permeable lens care liquid of an embodiment is PEO ₂₀PPO ₇₀PEO ₂₀

In another embodiment, to have chemical constitution be PEO to described hard air-permeable lens care liquid ₃₇PPO ₅₆PEO ₃₇The straight-chain polyether surfactant.

In one embodiment, provide a kind of method for preparing hard air-permeable lens care liquid, this method comprise with at least a biguanide antimicrobial and effective dose based on PEO-PPO-PEO, PPO-PEO-PPO and the bonded step of combination thereof.In said method, described lens care liquid can effectively clean the hard air-permeable eyeglass under the situation of not carrying out manual wiping or rinsing hard air-permeable eyeglass.In another embodiment, this solution comprises that the HLB value is less than or equal to 15, the mean molecule numerical quantity is the straight-chain polyether surfactant of 5000-7000.

In another embodiment, provide a kind of method that lens care liquid is used for the hard air-permeable eyeglass.This lens care liquid comprises at least a biguanide antimicrobial of sterilization amount and based on the straight-chain polyether surfactant of PEO-PPO-PEO, PPO-PEO-PPO and combination thereof, this lens care liquid can effectively clean the hard air-permeable eyeglass under the situation of not manual wiping or rinsing hard air-permeable eyeglass.This method comprises makes eyeglass contact the step that is suitable for reducing or removing a period of time that loads on the microorganism on the eyeglass with described solution, and directly eyeglass is placed on the eyes.

In another embodiment, this method provides the thorough cleaning of eyeglass, and it makes that finger wiping eyeglass is unessential for the cleaning eyeglass.Preferred this method is not being shaken, is being carried out under the situation of wiping and rinsing.In one embodiment, this solution comprises that the HLB value is less than or equal to 15, the mean molecule numerical quantity is the straight-chain polyether surfactant of about 5000-7000.

The specific embodiment

Compositions disclosed herein and lens care liquid can be used for all contact lenss, as the hard of routine and the eyeglass of soft type, and rigid and soft gas permeable lenses.Such eyeglass comprises hydrogel and non-aqueous gel eyeglass, and contains siloxanes and fluorine-containing eyeglass.Most importantly those skilled in the art think hard air-permeable (RGP) eyeglass, or more recent that class eyeglass as breathability (GP) eyeglass.Described compositions also can be used for the sterilization and the cleaning of medical device, particularly those polluted by protein substance those.

As skilled in the art to understand, normally siloxanes acrylic ester type or fluorosilicone-acrylic ester type of RGP eyeglass.Such material is usually made by siloxy group methacrylate such as 3-methacryloxypropyl three-(trimethylsiloxy) silane, the big monomer of difunctionality polymerizable siloxane, one or more cross-linking agent such as TEG dimethylacrylate, one or more hydrophobic monomers such as methyl methacrylate or hexafluoro isopropyl methyl acrylate and one or more hydrophilic monomers such as 2-hydroxyethyl meth acrylate, N-vinyl pyrrolidone and/or methacrylic acid.Often from 20% to 80% soft hydrogel lenses is different with moisture content wherein, and the RGP eyeglass has the moisture content less than 1% usually.

Preferably said composition is put into solution to be enough to the eliminating lip-deep harmful microbe concentration of contact lens in the minimum soak time of recommending.The minimum soak time of recommending is designed to commercial acceptable to consumer, and generally comprises on the package insert that solution uses.The probability that this solution also can be used as listerine do not got rid of in term used herein " disinfectant solution ", and perhaps this disinfectant solution also can be used for other purposes, and as daily cleaning, rinsing and the preservation of contact lens, this depends on the special formulation that contains theme composition.In addition, if need, compositions disclosed herein can be used in combination with other known sterilization or corrosion preventive compound.

When being used for solution, compositions disclosed herein is that physiology is compatible.Specifically, this solution is " ophthalmology safety " when using for contact lens, this means that the contact lens of crossing with solution-treated of the present invention directly places on the eyes and is suitable and safe when not carrying out rinsing.For by by for daily contact of the contact lens of solution-wet and eyes, this solution safety and comfortable.Ophthalmology safety solution has tensity and the pH compatible with eyes, and comprises according to International Organization for Standardization standard and food and drug administration (FDA) regulations are the material and the consumption thereof of no cytotoxicity accordingly.This solution should be aseptic, does not have microorgranic contaminant in this product of statistical confirmation before use, to such an extent as to reach the necessary degree of this product.

Compositions disclosed herein and lens care liquid comprise one or more biguanide antimicrobial and one or more surfactants as disinfectant.Described one or more biguanide antimicrobials exist with the total amount based on the about 0.000001-of composition total weight about 5.0%.Preferred one or more biguanide antimicrobials are with the about 5.0 weight % of about 0.00001-, the more preferably from about about 1.0 weight % of 0.00001-, the most preferably from about about 1.0 weight % existence of 0.0001-.Suitable antimicrobial agents in order for example comprises 1 without limitation, two [5-(rubigan) biguanide] (hibitane (Chlorhexidine)) or its water soluble salts, 1 of 1 '-hexa-methylene, two [5-(2-ethylhexyl) biguanide] (alexidine (Alexidine)) or its water soluble salts of 1 '-hexa-methylene, poly-(hexamethylene biguan-ide) or its water soluble salt, polyquaternary ammonium salt (polyquatemium)-1, ionene polymer and ester quat.

Suitable biguanide is described in US 3,428, and in 576,4,758,595 and 5,990,174, the full content of its each piece is combined in this by reference.Based on their the commercial availability that is easy to, preferred antimicrobial is to be also referred to as poly-(hexamethylene biguan-ide) poly-(aminopropyl biguanide) (PHMB) usually (PAPB) and 1,1 '-hexa-methylene two [5-(2-ethylhexyl) biguanide] (alexidine).

In a preferred form, with the combination of PHMB and alexidine individually or with other antimicrobial as the biguanide antimicrobial.And, have been found that the introducing of alexidine has significantly reduced the sterilization required time, and advantageously, when the eyeglass that immerses said composition was embedded eyes, compositions disclosed herein did not cause calcination and stimulation.

When being formulated as cleaning solution, compositions disclosed herein comprises one or more surfactants that advantage can be provided in cleaning effect and comfort aspect for about 0.001-about 6% of total amount by weight.As understandable, surfactant used herein should dissolve in the lens care liquid and constant muddiness, and should be to the eye tissue nonirritant.Suitable surfactant comprises without limitation, for example based on poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) water solublity ternary block polymer, i.e. (PEO-PPO-PEO), or poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide), i.e. (PPO-PEO-PPO) or its combination.PEO-PPO-PEO and PPO-PEO-PPO surfactant can be from Mt.Olive, and the BASF Corporation of New Jersey is with trade name

,

, With

Buy, and be further described in US4,820,352, its full content is combined in this by reference.

Polyethet surfactant is straight chain or line style polyethet surfactant, and belongs to a class material of so-called " poloxamer ".The line style polyethet surfactant is considered to not have branching or grafted junctional complex, but can comprise the functional group that side is hung.Straight-chain polyether surfactant disclosed herein comprises one or more having oxyalkylene (O-R-) straight chain of repetitive or polymeric component, wherein R has 2 to 6 carbon atoms.Their dissolubilities in water are good usually, but the qualitative change of single block copolymer is bigger.It is such being used for the also common nomenclature as used herein of block copolymer, when two numerals of beginning multiply by 100, the mean molecule quantity of the PO block of its expression poloxamer, when last numeral multiply by 10, the ethylene oxide content (%w/w) of its expression poloxamer.

Commercially available poloxamer surfactants rank can number-average molecular weight (mean molecule quantity) between being low to moderate 1650-27,000 and obtain.Other performance of each grade in this series depends on the % of the hydrophilic unit poly-(oxirane) in the adduct and the molecular weight of hydrophobic units poly-(propylene oxide).Although the whole members in this series demonstrate moistening and scourability, it is found that because the performance characteristic of being regulated by their hydrophile-lipophile balance (HLB) changes in wide region, so only there is some member to be applicable to cleaning disclosed herein and conditioning liquid.Those poloxamer surfactants that find to be fit to are that those can show with minimum solution concentration and disperse protein and lipoid thesaurismosis object space face that maximum cleaning efficiency is arranged under ambient temperature and elevated temperature, and not compromise aspect the eyeglass compatibility and toxic level, promptly keep as minimum probability to the eye tissue stimulus object.

The HLB value be less than or equal to 15 suitable straight-chain polyether surfactant comprise without limitation HLB for example be 8 and mean molecule quantity be 1630 L42 (BASF); HLB be 11 and mean molecule quantity be 2650

L63 (BASF); HLB be 1 and mean molecule quantity be 3800

L101 (BASF); HLB be 9 and mean molecule quantity be 4950

P103 (BASF); HLB be 8 and mean molecule quantity be 5750 P123 (BASF); HLB be 4 and mean molecule quantity be 5000

L122 (BASF); HLB be 1 and mean molecule quantity be 4400

L121 (BASF); HLB be 6 and mean molecule quantity be 3650

L92 (BASF); HLB be 2 and mean molecule quantity be 2750

L81 (BASF); HLB be 7 and mean molecule quantity be 2750

L72 (BASF); HLB be 7 and mean molecule quantity be 2500 L62 (BASF); HLB be 3 and mean molecule quantity be 2000

L61 (BASF); HLB be 5 and mean molecule quantity be 1100 L31 (BASF); And HLB be 15 and mean molecule quantity be 6500

P105 (BASF).

Particularly preferred HLB value is less than or equal to 15 straight-chain polyether surfactant and does to be sold by BASF AG

P123. P123 can be characterized by HLB as noted above be 8 and mean molecule quantity be 5750 PEO ₂₀PPO ₇₀PEO ₂₀Another kind of particularly preferred HLB value is to be less than or equal to 15 straight-chain polyether surfactant to be sold by BASF AG 105. P105 can be characterized by PEO ₃₇PPO ₅₆PEO ₃₇, and HLB as noted above be 15 and mean molecule quantity be 6500.As can be by understood by one of ordinary skill in the art, be surprised to find inventive compositions and under not by means of boratory situation, demonstrate excellent sterilization and/or Anticorrosive Character, the instruction of this and US 4,758,595 is opposite.

The polyethet surfactant of side chain can be added in the compositions disclosed herein.As

The husky amine in the pool Lip river of polyethet surfactant is particularly preferred branched surface active agent.The side chain polyethet surfactant is considered to star-type polymer, derivant that replaces as four polyethers of ethylenediamine or the like.Side chain polyethet surfactant disclosed herein comprises one or more to have oxyalkylene (O-R-) chain of repetitive or polymeric component, wherein R has 2 to 6 carbon atoms.Representational polyethet surfactant comprises the block polymer of two or more variety classes oxyalkylene repeat units, and its ratio is used for determining the HLB of described surfactant.

Suitable side chain and straight-chain polyether surfactant have the HLB value more than or equal to 18, and comprise without limitation HLB for example be 27 and mean molecule quantity be 12200

707 (BASF); HLB be 31 and mean molecule quantity be 25000

908 (BASF); HLB be 32 and mean molecule quantity be 30000

909 (BASF); HLB be 24 and mean molecule quantity be 15000

1107 (BASF); HLB be 24 and mean molecule quantity be 18000

1307 (BASF); And HLB be 27 and mean molecule quantity be 30000

1508 (BASF).Special preferably HLB is 32 and mean molecule quantity 30000

909 and HLB be 24 and mean molecule quantity 15000 1107 (BASF).

As has been noted, the HLB of known surface activating agent is the principal element of decision polyethet surfactant emulsifying feature.Usually, the surfactant with low HLB value is oleophylic more, and the surfactant with higher HLB value is more hydrophilic.The different HLB values of husky amine in various pools Lip river and poloxamer are by Wyandotte, and the BASF Wyandotte Corp. of Mich. provides.

Can with other HLB value more than or equal to 18 straight chain poly-(epoxy ethane-epoxy propane-oxirane) (PEO-PPO-PEO) block copolymer add in the Aquo-composition of the present invention.The example of appropriate materials is that HLB is that 18-23 and mean molecule quantity are 12600

F127 (BASF).

In one embodiment of the invention, use separately

P123, or use with other combinations-of surfactants.In another embodiment of the invention, use separately

P105 or use with other combinations-of surfactants.Have been found that

P123 and

P105 all can remove the lipoid thesaurismosis thing from the RGP lens surface effectively.

It is optional that what comprise can be one or more water solublity viscosity reagent.Because the alleviation effects of viscosity reagent has proved by provide thin film, buffering the impact of eyes to be had the trend of the comfort level that improves the lens wear person at lens surface.Suitable viscosity reagent comprises for example water-soluble cellulose polymer without limitation, as hydroxyethyl-cellulose, hydroxypropyl cellulose or hydroxypropyl emthylcellulose, guar gum, ethoxy guar gum, hydroxypropyl guar gum, hydroxypropyl methyl guar gum, poly-(N,N-DMAA), poly-(N-vinyl pyrrolidone), poly-(vinyl alcohol), poly-(ethylene glycol), poly-(oxirane) or the like.The consumption of viscosity reagent can be about 0.01-about 4.0% or still less.

Compositions disclosed herein also can comprise one or more buffer agents or buffer system, with the final pH of regulator solution.Suitable reducing comprises for example citrate buffer agent without limitation, phosphate buffer, borate buffer, three (methylol) aminomethane (Tris) buffer agent, sodium bicarbonate, and the non-limiting N that comprises of Good buffer agent (Good Buffers), N '-two (2-ethoxy) glycine (BICINE), two (2-ethoxy) amino of 2-[]-2 (methylol)-1, ammediol (BISTRIS), 2-(cyclohexyl amino) ethane-2-sulfonic acid (CHES), N-(2-ethoxy) ethylenediamine-N, N ', N '-triacetic acid (EDTA-OH), N-(2-hydroxypropyl) ethylenediamine-N, N ', N '-triacetic acid (propyl group-EDTA-OH), N-2-(ethoxy)-piperazine-N '-2 ethane sulfonic aicd (HEPES), N-(2-ethoxy)-piperazine-N '-3-propane sulfonic acid (HEPPS), morpholino ethane sulfonic acid (MES), morpholino propane sulfonic acid (MOPS), piperazine-N, N '-two (2 ethane sulfonic aicd) is (PIPES), N-three (methylol) methyl-2-aminoethane sulphonic acid (TES), N-three (methylol) methyl-3-amino propane sulfonic acid (TAPS) and N-three (methylol)-methylglycine (TRICINE) and combination thereof.Well-known Good buffer agent (Good N.E. etc., (1966) Biochemistry, 5,467-477) pair cell is nontoxic, be not adsorbed by cell membrane, and feature pKa value is positioned at physiological pH or near physiological pH.The pH of lens care liquid disclosed herein preferably remains on 5.0-8.0, more preferably from about 6.0-8.0, most preferably from about 6.5-7.8.

Also can comprise one or more tonicity agents (penetrating agent), with the osmotic pressure near normal lachrymal gland liquid, it is equivalent to 0.9% sodium chloride solution or 2.5% glycerol.Non-limiting zinc chloride, sodium chloride, potassium chloride, glucose, mannose, glycerol, propylene glycol, calcium chloride and the magnesium chloride of comprising of the example of suitable tonicity agents.These reagent are general independent with about 2.5%w/v of about 0.01-and preferred consumption use from the about 1.5%w/v of about 0.2-.The available final osmotic value of the consumption of predetermined tension agent is 200-450mOsm/kg, and the about 350mOsm/kg of more preferably about 205-most preferably is 210-about 320

mOsm/kg。

Compositions disclosed herein can also comprise one or more chelating agen with the constraint metal ion, and with regard to the situation of ophthalmic solution, metal ion can and accumulate on the contact lens with the protein deposit reaction.Suitable chelating agen comprises for example ethylenediaminetetraacetic acid (EDTA) and its salt, gluconic acid, citric acid, tartaric acid and its salt such as sodium salt without limitation.The preferable amount of chelating agen is the about 0.2 weight % of about 0.01-.

Can also choose wantonly and comprise one or more cationic polysaccharides.When using, described one or more cationic polysaccharides exist with the total amount based on the about 0.5 weight % of the about 0.001-of composition total weight, more preferably from about the about 0.05 weight % of 0.005-.The suitable cationic polysaccharide that is used for compositions disclosed herein for example comprises without limitation: the version of polyquaternary ammonium salt-10 (Polyquaternium) is 75-125cPs and the Polymer JR125 that contains 1.5-2.2% nitrogen such as, but be not limited to the viscosity of 2% solution ^TM(Midland, the Dow chemical company of Michigan), the viscosity of 2% solution is 300-500cPs and the Polymer JR 400TM (Dow chemical company) that contains 1.5-2.2% nitrogen, and the viscosity of 1% solution is 1,000-2,500cPs and contain the Polymer JR 30M of 1.5-2.2% nitrogen ^TM(Dow chemical company), the viscosity of 2% solution is 300-500cPs and the Polymer LR 400 that contains 0.8-1.1% nitrogen ^TM(Dow chemical company), the viscosity of 1% solution is 1,250-2,250cPs and contain the Polymer LR30MTM (Dow chemical company) of 0.8-1.1% nitrogen and the viscosity of 2% solution is 300-500cPs and the Polymer LK that contains 0.8-1.1% nitrogen ^TM(Dow chemical company).Preferred cation polysaccharide used herein is PolymerJR125TM or Polymer JR 400 ^TM

Compositions disclosed herein can also comprise one or more water-soluble saccharides.Such saccharide is present in the compositions of the present invention with the total amount based on the about 10.0 weight % of the about 0.01-of the gross weight of compositions, but about 5.0 weight % of 0.05-more preferably from about.Suitable carbohydrate used herein comprises for example monosaccharide, disaccharide, oligosaccharide and polysaccharide without limitation.Suitable monosaccharide comprises for example allose, altrose, glucose, mannose, gulose, idose, galactose, talose, ribose, arabinose, xylose and lyxose without limitation.The example of suitable disaccharide is sucrose and trehalose.The suitable oligosaccharide that constitutes by two-eight unitary monosaccharide and comprise for example agar without limitation by surpassing the polysaccharide that eight unit monosaccharide constitute, agarose, guar gum, hydroxypropyl guar gum, the hydroxypropyl methyl guar gum, the ethoxy guar gum, carboxymethyl guar glue, Radix Acaciae senegalis, glucosan, locust bean gum, alginate, Devil's dung, benzoin, carragreenans, carob, Colophonium (colophone), galbanum, gum dammar, cassia gum, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, methylcellulose, carboxymethyl cellulose, tunny gum, elemi glue (gum elemi), gamboge (gum gambodge), gum rosin (gum rosin), the mountain reaches glue, tara gum, oleoresin adhesive (gumterpentine), tragacanth, xanthan gum, Y. flaccida Haw. glue, pectin, gellan gum, hyaluronic acid, chondroitin sulfate, Ficus elastica, more create glue (gum guaiac), guaiac resin (gum guaiac), Guarana glue, gutta-percha, karaya, Konjac glucomannan, frankincense gum (mastix), Myrrha glue and frankincense gum (olibanum).

Theme composition also can comprise the surface that wetting agent promotes said composition moistening contact lens.In the prior art field, term " wetting agent (humectant) " also is generally used for describing these materials.First kind wetting agent is the aggretion type wetting agent.The example of suitable wetting agent for example comprise without limitation polyvinyl alcohol (PVA), poly-(N-vinyl pyrrolidone) (PVP), water-soluble cellulose derivative such as hydroxypropyl emthylcellulose and Polyethylene Glycol.If desired, water-soluble cellulose derivative and PVA can also be used to increasing the viscosity of said composition, and can provide this advantage if required.Concrete cellulose derivative comprises for example hydroxypropyl emthylcellulose, carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose and cationic cellulose derivative without limitation.As be disclosed in US 6,274,133 like that, cationic cellulose polymer helps also to prevent that lipoid and protein are accumulated to the surface of hydrophilic lens.Such cationic cellulose polymer for example comprises without limitation, can with the water-soluble polymer that trade mark Polyquaternium-10 is purchased, comprising can be with trade name according to CTFA (Cosmetic, Toiletry, and Fragrance Association) Polymers is from Amerchol Corp., Edison, the cationic cellulose polymer that New Jersey is purchased.Usually, these cationic cellulose polymers comprise with the quaternised N of cellulosic polymer chain, N-dimethylamino group.

Another kind of suitable wetting agent is non-aggretion type wetting agent.Example comprises two pure and mild dihydroxylic alcohols of glycerol, propylene glycol and other non-polymeric type.

The concrete consumption of wetting agent used herein depends on application.Yet the amount of the wetting agent that comprises usually is the about 5 weight % of about 0.01-, the about 2 weight % of preferably about 0.1-.

In following examples, inventive compositions will be described in more detail.

In following examples, some chemical constituent is equal to following abbreviation.

HAP: the hydroxyalkyl phosphide (Hydroxyalkyl-phosphorate) in phosphate buffered saline (PBS) (PBS) has every milliliter of 0.5U aprotinin-0.05% human serum albumin-3mM D-glucose;

Cationic polysaccharide, polyquaternary ammonium salt-10; With

Alexidine 2HCl: quaternary ammonium salt, 1,1 '-hexa-methylene two [5-(2-ethylhexyl) biguanide]

Embodiment 1-14 contain PHMB HCl and

The biocidal routine tests of the compositions of P123

Evaluation by

The solution of P123 and PHMB HCl preparation carries out the antibacterial effect of chemical disinfection to the contact lens that uses 10% organic pollution.Solution component is listed in the table below in 1 to 14.

The microorganism attack inoculum adopts bacillus pyocyaneus (ATCC 9027), staphylococcus aureus (ATCC 6538), serratia marcescens (ATCC 13880), Candida albicans (ATCC 10231) and Fusarinm solani (ATCC 36031) preparation.The test Organic substance is cultivated on suitable agar, and used aseptic Dulbecco phosphate buffered saline (PBS) to add the polysorbate80 (DPBST) or the suitable diluent collection culture of 0.05% weight/volume, and transfer in the proper container.Spore suspension is filtered to remove the mycelia fragment by aseptic glass cotton.Depend on the circumstances, the filter of serratia marcescens by 1.2 microns filtered with clarified suspension.After the collection, suspension was descended centrifugal maximum 30 minutes at 20-25 ℃ to be no more than 5000 * g.The supernatant is inclined to and suspension once more in DPBST or other suitable diluent.With suspension centrifugalize for the second time, and in DPBST or other suitable diluent resuspending.

All attack bacteria and fungal cell's suspension are adjusted to 1 * 10 with DPBST or other suitable diluent ⁷-1 * 10 ⁸Cfu/mL.Suitable cell concentration can be estimated by the turbidity of measuring suspension, for example, use spectrophotometer with presetted wavelength such as 490nm.Prepare a test tube, it comprises every kind of test solution of attacking the minimum 10mL of Organic substance.To the organic suspension of test of the every pipe solution inoculation q.s that will test, to provide 1 * 10 ⁵To 1 * 10 ⁶The final counting of cfu/mL, the volume of inoculum is no more than 1% of sample volume.The dispersion of inoculum by eddy current rotary sample at least 15 seconds to guarantee.To inoculate product 20-25 ℃ of storage down.Amount is taken out from the inoculation product for the aliquot of 1.0mL, to determine the count plate after specific disinfecting time section.When the soak time of being suggested plans is four hours to 25%, 50%, 75%, 100% and 400% soak time, it is for example 1,2,3,4 and 24 hour for the time point of antibacterial.Suspension was rotated at least 5 seconds with abundant mixing by strong eddy current.The 1.0mL aliquot of taking out in specified time interval is effectively being carried out a series of suitable dilutions with ten times (decimal) in the neutralization medium.Suspension is acutely mixed, and cultivate one suitable period, so that the microorganism reagent neutralization.

In order to prove the fitness of the medium that is used for the growth test biology, and provide prediction to the initial inoculation substrate concentration, with the inoculum of identical aliquot be distributed to adopt equal volume be used for suspending the suitable diluents such as the DPBST of above-mentioned organic diluent, with preparation inoculum reference examples.Inoculation and cultivating suitable a period of time in effective neutralizer, the inoculum reference examples must be between 1.0 * 10 ⁵With 1.0 * 10 ⁶Cfu/mL.

Be used for antibacterial by the tryptic soy agar (TSA) for preparing three parts of plates, and sabouraud's glucose agar (SDA) is used for mycete and yeast and measures organic count plate in proper diluent.Antibacterial is reclaimed plate to be cultivated two to four days down at 30-35 ℃.Yeast is reclaimed plate to be cultivated two to four days down at 20-30 ℃.Mycete is reclaimed plate to be cultivated three to seven days down at 20-25 ℃.The average of colony-forming units is measured on isarithmic plate.Isarithmic plate is suitable for the 30-300cfu/ plate for antibacterial and yeast, mycete is suitable for the 8-80cfu/ plate, except when only for 10 ⁰-10 ^-1When the dilution plate is observed bacterium colony.The minimizing of microorganism is calculated to put preset time, and is recorded in the following table 1-table 14.

Biocidal result among the embodiment 1-14 reaches Stand Alone Procedure the requirement 1 and 4 hour under of ISO for Contact Lens DisinfectingProducts.The result shows that also 10% organic pollution of existence can not reduce use prescription disclosed herein and attack organic biocidal effects to five kinds.

Organic pollution is a heat shock saccharomyces cerevisiae [1 * 10 ⁷]/milliliter and the blended mixture of serum bovine albumin.In order to obtain 10% concentration, mixture is diluted to 9 parts with PBS from 1 part.

Table 1

Table 2

Table 3

Table 4

Table 5

Table 6

Table 7

Table 8

Table 9

Table 10

Table 11

Table 12

Table 13

Table 14

Embodiment 15-32 adopts PHMB HCl: alexidine 2HCl and

The combination of P123 The biocidal routine tests of thing

Test to investigate and use according to the present invention

The prepared solution of combination of P123 and PHMB HCl and alexidine 2HCl is to adopting the microorganism killing effect of 10%, 50% and 100% organic pollution.Test solution marks in following table 15-32.Each is used for the antibacterial effect of chemical disinfection contact lens and estimates according to the listed method of embodiment 1-14.

The microorganism of the organic pollution of employing 10% reduces calculates at particular point in time, and is recorded in the listed record of following table 15-28.The microorganism of the organic pollution of employing 100% reduces at particular point in time calculates, and is recorded in the listed record of following table 29-30.The microorganism of the organic pollution of employing 50% reduces at particular point in time calculates, and is recorded in following table 31 to the 32 listed records.

Table 15

Table 16

Table 17

Table 18

Table 19

Table 20

Table 21

Table 22

Table 23

Table 24

Table 25

Table 26

Table 27

Table 28

Table 29

Table 30

Table 31

Table 32

Embodiment 33-prepares preparation

Table 33 has been listed the component of the basic preparation that is used for embodiment.

Table 33: basic preparation

Table 34 has been listed the real surface surfactant concentration of preparation I-IV.All preparations mix with water and prepare by basic preparation, the surfactant that will respectively estimate one's own ability.Afterwards preparation is filtered.

Table 34: the composition of preparation I-IV

Embodiment 34-lipoid cleaning and toxicity are investigated

The spectrophotometry that the lipoid cleaning is investigated based on suspension carries out, and suspension comprises the mixture of orange (Sudan I) and cholesterol.Test the ability 24 hours of the preparation dissolving lipoid of 10 ml volumes in room temperature.The absorptance value is high more, and the lipoid cleaning effect of preparation is high more.Interpolation 0.1%

P105 (preparation IV:HLB value is 15) has statistically increased the cleaning value of reference composition (preparation III) to lipoid.

Toxicity data is used to predict that the cell culture model of the eye irritation potential (test of Na-fluorescent penetrant rate) of new contact lens care composition produces.All these preparations all demonstrate the penetration value that is lower than contrast preparation I.Contrast preparation I is the safe ophthalmic nursing product that existing market is sold.

Table 35: lipoid cleaning and the toxicity of preparation I-IV

Preparation Article Number #	I	II	II	IV
Preparation Article Number #	I	II	II	IV	Lipoid cleaning value	330	390	594	707
Toxicity (flat fluorescent)	49	35	45	48	Lipoid cleaning value	330	390	594	707

Embodiment 35-antiseptic effect

Table 36 is depicted as the result of the antiseptic effect of preparation I-IV.Antiseptic effect is tested according to top disclosed method.Each of preparation I-IV has all been passed through preservative efficacy test.

Table 36: the antiseptic effect of preparation I-IV

Embodiment 36-is right

F127 and

The dose response of P105 in 1107

Preparation preparation I, II, V and V1.Carry out the lipoid cleaner assay according to the above-mentioned clean method that is used for lipoid.The activity of the high more presentation surface activating agent of lipoid cleaning value is high more.The result shows, when adding 0.05 weight %-0.1 weight %'s

During P105, the lipoid of contrast preparation (preparation I) cleaning significantly improves.

Table 37:

These data representations be for P105 is comprising 3%

F127 and 1.5%

Dose response in 1107 the solution and threshold limit value.

Table 38

These data representations be, can be by use increasing concentration

105 and have a lower total surfactant concentration, and keep the lipoid cleaning.

Prove as top, one or more biguanide antimicrobials of the sterilization amount that comprises disclosed herein and

P123 or

The compositions of P105 can be used for the contact lens conditioning liquid and the RGP contact lens of sterilizing fast.As will be appreciated, the sterilization amount of antimicrobial is to reduce microbe quantity purpose amount in used preparation to small part.Preferably, sterilization amount is the amount that can reduce the load of microorganisms of the representative antibacterial of 3log power in 4 hours, reach the representative fungus of minimizing 1log power.Most preferably, when according to as (International Standards for Ophthalmic Optics)/(ISO/DIS 14729 for FDA sterilizing test independent solution by ISO; When 2001)) scheme of the recommendation soak time of Zhi Dinging was used, the sterilization amount was to remove the amount that each test microorganism on the contact lens surpasses the load of microorganisms of 10cfu.Generally, such reagent exists with the concentration range of about 0.5% weight/volume of about 0.00001-(w/v), more preferably from about the about 0.5%w/v of 0.00003-.The anticorrosion amount of antimicrobial is to prevent to adopt the material of said composition or the amount of installing biodeterioration.The anticorrosion amount of antimicrobial is the about 5.0 weight % of about 0.0001-in inventive compositions, more preferably from about the about 1.0 weight % of 0.001-, the most preferably from about about 0.50 weight % of 0.025-.

As mentioned above, the cleaning contact lens needn't carry out manual wiping, contacts and can sterilize fast with the solution of type disclosed herein by making eyeglass.This realizes by the solution that makes contact lens and soak simply or immerse several milliliters of inventions.Preferably, make contact lens in solution, soak at least one time to four hours.Then contact lens is taken out from solution, optional with identical or different solution such as anticorrosion normal isotonic saline solution rinsing, put back on the eyes then.

The solution that comprises one or more present compositions can be mixed with special contact lens care product and use, as in the field of ophthalmology routine.Such product is non-limiting to comprise wetting solution, soak, cleaning and conditioning liquid, and multipurpose lens care liquid and ophthalmic cleaning and conditioning liquid.

The solution that comprises one or more compositionss of type disclosed herein can be formulated as the sterilization medical device, such as, but not limited to the specific product of contact lens.

The product that comprises one or more compositionss of type disclosed herein can be prepared and be used for anticorrosion microbial contamination, such as but be not limited to ophthalmic solution, medicine, artificial tears and the drop of releiving.The solution that comprises one or more compositionss of type disclosed herein can be formulated as and be used to preserve the specialities that medical device is not subjected to microbial contamination, for example, but is not limited to the product that preparation is used to store contact lens.

Though invention has been described and be illustrated with reference to specific embodiment, those of ordinary skill in the art is to be understood that the present invention is applicable to herein the not necessarily version of explanation.Then, therefore, should be only with reference to appended claim to determine actual range of the present invention.

Embodiment 37-40 test have PHMB, alexidine and The scheme of P123

On the RGP eyeglass, do not have rinsing (NR/NR) scheme in the no wiping that has and do not have to shake for 10 seconds under the step (ss) four kinds of multipurpose solution using 10 milliliters to carry out four hours, test be known as have most in five kinds of microorganisms repellence anti-candida albicans ATCC10231.(the RGP eyeglass is commercially available from Rochester, the Bausch ﹠amp of NY; Lomb of's

Be to produce by enflufocon A.) the composition of four kinds of multipurpose solution among the embodiment 37-40 be listed in the table below 39 and table 40 in.

The performance requirement of this scheme need and filter the combination recovery from organic each eyeglass of various tests and be less than or equal to 10 colony-forming units (CFU).Be listed in the table below in 39 and 40 for the test result of this scheme.All compositionss of the present invention all satisfy the scheme standard of Candida albicans.

Adopt the Stand-Alone Biocidal research of 10% organic pollution as described in table 39 and 40, on four multipurpose solution of embodiment 37-40, to implement, with the whole antibacterial effect of the multipurpose solution that shows four samples of the present invention.Organic pollution is heat shock saccharomyces cerevisiae [1 * 107]/milliliter and the blended mixture of serum bovine albumin.In order to obtain 10% concentration, mixture is diluted to 9 parts with PBS from 1 part.The situation of the anti Bacillus pyocyaneu Flugge ATCC of testing liquid 9027, staphylococcus aureus ATCC6538, serratia marcescens ATCC 13880, Candida albicans ATCC 10231 and Fusarinm solani ATCC 36031.

The result of study of Stand-Alone Biocidal also is listed in the table below in 39 and 40.For the given disinfecting time of the directed toward bacteria that is equivalent to potential minimum recommended disinfecting time, its basic standard is to be no less than 3.0log in given disinfecting time.And the mycete of every milliliter of recovery and zymic number must reduce the meansigma methods that is no less than 1.0log in the minimum recommended disinfecting time, and do not have increase during in the minimum recommended disinfecting time four times (24 hours).Four kinds of multipurpose solution of all of embodiment 37-40 satisfy the scheme standard of whole five kinds of microorganisms.

The digital proof of embodiment 37-40 NR/NR RGP multipurpose solution of the present invention for the test of independent biocidal with there is not the two effective antibiotic pattern of wiping/no rinsing scheme.

Table 39

Table 39 is continuous

CFU=colony-forming units 10ss=10 shakes second

Log reduces, 〉=100% kill NS=and do not shake

NR/NR=does not have wiping, no rinsing

Table 40

CFU=colony-forming units Log reduces, 〉=100% kill

10ss=10 shakes NR/NR=second is not had wiping, no rinsing

NS=does not shake

Embodiment 41-44-contains

The test of the compositions of P105

Embodiment 41-prepares preparation

Table 41 has been listed the component of the basic preparation of embodiment

Table 41: basic preparation

Table 42 has been listed the real surface surfactant concentration of preparation I-IV.All preparations all mix with water and prepare by basic preparation, the surfactant that will respectively estimate one's own ability.Afterwards preparation is filtered.

Table 42: the composition of preparation I-IV

Embodiment 42-lipoid cleaning and toxicity are investigated

The spectrophotometry that the lipoid cleaning is investigated based on suspension carries out, and this suspension comprises the mixture of orange (Sudan I) and cholesterol.Test the ability 24 hours of the preparation dissolving lipoid of 10 ml volumes in room temperature.The absorptance value is high more, and the lipoid cleaning effect of preparation is high more.Interpolation 0.1%

Table 43: lipoid cleaning and the toxicity of preparation I-IV

Embodiment 43-antiseptic effect

Table 44 is depicted as the result of the antiseptic effect of preparation I-IV.Antiseptic effect is tested according to top disclosed method.Each of preparation I-IV has all been passed through preservative efficacy test.

Table 44: the antiseptic effect of preparation I-IV

Embodiment 44-to F127 and

In 1107

The agent of P105 Quantitative response

Preparation preparation I, II, V and V1.Method according to the example II that is used for the lipoid cleaning is carried out the lipoid cleaner assay.Lipoid cleaning value is high more, and is high more with regard to the activity of presentation surface activating agent.The result shows, when adding 0.05 weight %-0.1 weight %'s

Table 45

These data representations be for P105 is comprising 3%

F127 and 1.5%

Dose response in 1107 the solution and threshold limit value.

Table 46

These data representations be, can be by use increasing concentration

P105 and have lower total surfactant concentration, and keep the lipoid cleaning.

P123 or

The compositions of P105 can be used for the contact lens conditioning liquid RGP contact lens of sterilizing fast.Such as will be appreciated, the sterilization amount of antimicrobial is to reduce microbe quantity purpose amount in used preparation to small part.

Claims

1, a kind of hard air-permeable lens care liquid, described lens care liquid comprise at least a biguanide antimicrobial of sterilization amount and based on the straight-chain polyether surfactant of PEO-PPO-PEO, PPO-PEO-PPO and combination thereof,

Wherein said lens care liquid can be under the situation of the manual described hard air-permeable eyeglass of wiping or rinsing this hard air-permeable eyeglass of cleaning.

2, the hard air-permeable lens care liquid of claim 1, the HLB value of wherein said straight-chain polyether surfactant is for being less than or equal to 15, and the mean molecule numerical quantity is about 5000-7000.

3, the hard air-permeable lens care liquid of claim 1, the chemical constitution of wherein said straight-chain polyether surfactant is PEO ₂₀PPO ₇₀PEO ₂₀

4, the hard air-permeable lens care liquid of claim 1, the chemical constitution of wherein said straight-chain polyether surfactant is PEO ₃₇PPO ₅₆PEO ₃₇

5, the hard air-permeable lens care liquid of claim 2, wherein said biguanide is selected from PHMBHCl, alexidine 2HCl and combination thereof.

6, the hard air-permeable lens care liquid of claim 5, wherein said biguanide is PHMBHCl.

7, the hard air-permeable lens care liquid of claim 5, wherein total biguanide concentration is about 0.0001-1.0 weight %.

8, the hard air-permeable lens care liquid of claim 1, it also comprises buffer agent.

9, the hard air-permeable lens care liquid of claim 8, wherein said buffer agent is an ethanolamine.

10, the hard air-permeable lens care liquid of claim 1, the pH of wherein said conditioning liquid are that 6.0-is about 7.0, and Osmolality is the about 320mOsm/kg of about 210-.

11, the hard air-permeable lens care liquid of claim 1, it also comprises EDTA.

12, the hard air-permeable lens care liquid of claim 1, it also comprises penetrating agent.

13, the hard air-permeable lens care liquid of claim 12, wherein said penetrating agent is a glycerol.

14, a kind of method for preparing hard air-permeable lens care liquid, it may further comprise the steps:

(a) with at least a biguanide antimicrobial and effective dose, mix based on the straight-chain polyether surfactant of PEO-PPO-PEO, PPO-PEO-PPO and combination thereof,

Wherein said lens care liquid is not manually effectively cleaning this hard air-permeable eyeglass under the situation of wiping or rinsing hard air-permeable eyeglass.

15, the method for claim 14, the HLB value of wherein said straight-chain polyether surfactant is for being less than or equal to 15, and the mean molecule numerical quantity is about 5000-7000.

16, the method for claim 14, the chemical constitution of wherein said straight-chain polyether surfactant are PEO ₂₀PPO ₇₀PEO ₂₀

17, the method for claim 14, the chemical constitution of wherein said straight-chain polyether surfactant are PEO ₃₇PPO ₅₆PEO ₃₇

18, the method for claim 14, wherein said biguanide are selected from PHMB HCl and alexidine 2HCl and combination thereof.

19, the method for claim 18, wherein said biguanide are PHMB HCl.

20, the method for claim 19, wherein total biguanide concentration is about 0.0001-1.0 weight %.

21, the method for claim 14, it is further comprising the steps of:

(b) buffer agent is added in the described conditioning liquid.

22, the method for claim 21, wherein said buffer agent are ethanolamine.

23, the method for claim 22, the pH of wherein said conditioning liquid is that 6.0-is about 7.0, Osmolality is the about 320mOsm/kg of about 210-.

24, the method for claim 14, it is further comprising the steps of:

(c) EDTA is added in the described conditioning liquid.

25, the method for claim 24, it is further comprising the steps of:

(d) penetrating agent is added in the described conditioning liquid.

26, the method for claim 25, wherein said penetrating agent are glycerol.

27, a kind of method that lens care liquid is used for the hard air-permeable eyeglass, described lens care liquid comprises at least a biguanide antimicrobial of sterilization amount, and based on the straight-chain polyether surfactant of PEO-PPO-PEO, PPO-PEO-PPO and combination thereof, this lens care liquid is not manually effectively cleaning this hard air-permeable eyeglass under the situation of wiping or rinsing hard air-permeable eyeglass, said method comprising the steps of: eyeglass is contacted with conditioning liquid be suitable for reducing or removing a period of time that loads on the microorganism on the eyeglass, and directly eyeglass is placed on the eyes.

28, the method for claim 27, wherein said method provide the thorough cleaning of eyeglass, and it makes and need not to clean eyeglass with finger wiping eyeglass.

29, the method for claim 28, wherein said contact is not being shaken, is being carried out under the situation of wiping and rinsing.

30, the method for claim 27, the HLB value of wherein said straight-chain polyether surfactant is for being less than or equal to 15, and the mean molecule numerical quantity is about 5000-7000.

31, the method for claim 27, the chemical constitution of wherein said straight-chain polyether surfactant are PEO ₂₀PPO ₇₀PEO ₂₀

32, the method for claim 27, the chemical constitution of wherein said straight-chain polyether surfactant are PEO ₃₇PPO ₅₆PEO ₃₇

33, the method for claim 27, wherein said biguanide are selected from PHMB HCl and alexidine 2HCl and combination thereof.

34, the method for claim 33, wherein said biguanide are PHMB HCl.

35, the method for claim 34, wherein total biguanide concentration is about 0.0001-1.0 weight %.

36, the method for claim 27, wherein said lens care liquid also comprises buffer agent.

37, the method for claim 36, wherein said buffer agent are ethanolamine.

38, the method for claim 27, wherein said lens care liquid also comprises EDTA.

39, the method for claim 27, wherein said lens care liquid also comprises penetrating agent.

40, the method for claim 39, wherein said penetrating agent is a glycerol.