CN101396466A - Cold medicine tea composition as medicine and food, preparation method and use thereof - Google Patents
Cold medicine tea composition as medicine and food, preparation method and use thereof Download PDFInfo
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Abstract
The invention relates to an officinal and edible medicinal tea composition for treating cold, a preparation method and application thereof. The composition is made from the raw materials consisting of the following Chinese medicinal herbs: fruit of Grosvenor momordica, honeysuckle flower, boat-fruited sterculia, houttuynia, purple common perilla, finger citron and mulberry leaf. The invention also relates to a preparation method of the composition and application of the composition to preparing drugs, foods and health products for treating the cold, fever and pharyngolaryngitis. The medicinal tea composition has obvious curative effects on pharyngolaryngitis while treating the cold and the fever, and can be administered for a long time.
Description
Technical field
The present invention relates to the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, have the cough-relieving of regulating the flow of vital energy, promote respiratory system to recover, be used for the treatment of sick medicinal and edible Chinese medicine composition and method of making the same such as flu, fever, also relate to the application of said composition in preparation common cold medicine.
Background technology
Common cold also is called cold, comprises cough (as sore throat etc.) and fever etc.The disease of respiratory system such as pharyngolaryngitis, sore throat or fever person also belong to the category of common cold.Respiratory system disease is multiple disease mostly, rapid onset, infectivity.The condition of illness nasal obstruction, it is own weak all over that patient Chang Neng feels,
Adopting the means of Chinese medicine to treat cold disease, is to improve the health channel extremely leaved for development that enhances and glorifies the unique cultural features of a nation, and this is because therefore Chinese medicine characteristics such as to have the property of medicine gentle, applied widely are having its original effect aspect common cold treatment.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of the medicine-food two-purpose of common cold, said composition is prepared from by the raw material of Chinese medicine of the medicine-food two-purpose of following weight ratio:
Fructus Momordicae Flos Lonicerae Semen Sterculiae Lychnophorae Herba Houttuyniae Folium Perillae Fructus Citri Sarcodactylis Folium Mori
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Fructus Momordicae 1--156 Flos Lonicerae 1--126 Semen Sterculiae Lychnophorae 2-200
Herba Houttuyniae 3--200 Folium Perillae 3--210 Fructus Citri Sarcodactylis 1-256 Folium Mori 3--260
Most preferably, said composition is formed by the medicinal and edible Chinese medicine feedstock production of following weight ratio:
Fructus Momordicae 12 Flos Loniceraes 12 Semen Sterculiae Lychnophoraes 20 Herba Houttuyniae 25
Folium Perillae 30 Fructus Citri Sarcodactylis 10 Folium Mori 35
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes tablet, capsule, and beverage, bag tea, cookies, oral liquid or injection etc., preferred but be not limited to oral liquid.In order to prepare these preparations, can in compositions of the present invention, add conventional pharmaceutically acceptable auxiliaries as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral liquid, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, this method comprise clean, dry and above seven flavor raw material of Chinese medicine are ground into coarse powder, cross No. two and sieve, put into the extraction pot of band distillator, add water 5-10 and doubly measure, soaked 2-5 hour, stir 2-5 time therebetween, each 10-20 minute, heating extraction 1-3 hour, it was an amount of to collect distillate, and cold preservation was placed 8-12 hour down, precipitation is filtered.
Subsequently, can preparation of compositions of the present invention be become various dosage forms according to the ordinary skill in the art.For example get filtrate, can add flavoring agent and/or antiseptic if desired, regulate pH value to 7.0, and adjust total amount with sodium hydroxide, embedding, sterilization, packing promptly gets oral liquid of the present invention.
The present invention adopts the preparation technology of the way of distillation, and the volatile ingredient straight run distillation in Radix Aristolochiae and all the other the 3 flavor medical materials is come out promptly, and technology is simple.So in fact the present invention is exactly the aqueous solution of various volatile ingredients.Preferably described water is distilled water.
Need to prove that method of the present invention is a kind of preferable preparation technique but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral liquid treatment common cold obtains better curative effect, does not see any toxic and side effects.
Because common cold is a respiratory system is main disease, is monarch so adopt with Herba Houttuyniae, Folium Perillae ventilation in the side, and Fructus Momordicae, Fructus Citri Sarcodactylis cough-relieving are minister, and Flos Lonicerae, Semen Sterculiae Lychnophorae antiinflammatory are assistant, and Folium Mori are messenger drug.
[composition] Fructus Momordicae Flos Lonicerae Semen Sterculiae Lychnophorae Herba Houttuyniae Folium Perillae Fructus Citri Sarcodactylis Folium Mori etc.
[character] this product is faint yellow supernatant liquid, gas perfume (or spice), and it is little sweet to distinguish the flavor of.
[function cures mainly] ventilation, antiinflammatory, cough-relieving, bring down a fever, be used for the treatment of flu, fever, pharyngolaryngitis etc.
[usage and dosage] oral one time 10-30 milliliters, 2-3 times on the one or follow the doctor's advice.
Have no adverse reaction after [untoward reaction] medication.
[points for attention] 1, period in a medicine are forbidden share with other Chinese medicine.2, period in a medicine is forbidden share with antiallergic agent.3, pungent, the bean system group food of period in a medicine fasting.4, as taking other medicines, please Ref Dr or pharmacist before use this product.
For this reason, another object of the present invention provides a kind of present composition in preparation treatment flu, fever, pharyngolaryngitis, the application in the medicines such as nasal obstruction.
Description of drawings
Accompanying drawing 1 is preparation technology's flow chart of oral liquid of the Chinese medicine composition of invention.
The specific embodiment
Embodiment 1
Oral liquid:
Clean, dry raw material of Chinese medicine and consumption:
Fructus Momordicae 12 Flos Loniceraes 12 Semen Sterculiae Lychnophoraes 20 Herba Houttuyniae 25
Folium Perillae 30 Fructus Citri Sarcodactylis 10 Folium Mori 35
Method for making: above seven flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, regulate pH value to 7.0, and adjust total amount to 1000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Character: this product is an achromaticity and clarification liquid; Gas perfume (or spice), puckery, little hardship.
Differentiate: get this product 200ml, put in the round-bottomed flask, connect condensing tube (should be short and small) heating and be distilled to about 1 minute of boiling, when treating that crystallization appears in the condensing tube inwall, withdraw thermal source immediately, collect agglomerative crystallization on distillate (about 2-3ml) and the condensing tube inwall.
(1) it is an amount of to take by weighing the crystallization of separating out, and adds ethanol and makes dissolving, and make the solution that every 1ml contains 2.5mg, as need testing solution.According to ultraviolet-visible spectrophotometer method (appendix VA of Chinese Pharmacopoeia version in 2005) test, be blank with ethanol.Measure absorption curve between wavelength 230-350nm, its absorption curve should be consistent with the absorption curve of Radix Ginseng reference substance solution (1ml contains 2.5ml), at wavelength 289 ± 1nm place one maximum absorption band should be arranged.
(2) getting this product distillate, according to ultraviolet visible spectrophotometry (appendix VA of Chinese Pharmacopoeia version in 2005) test, is blank with water.Wavelength place at wavelength 250-350nm measures absorption curve, at 277 ± 1nm place, a maximum absorption band should be arranged.
Check: relative density should be not less than 0.9 (appendix VIIA of Chinese Pharmacopoeia version in 2005).
PH value should be 5.5-7.5 (an appendix VII of Chinese Pharmacopoeia version in 2005 G).
Other should meet every regulation relevant under the mixture item (appendix IJ of Chinese Pharmacopoeia version in 2005).
Usage and consumption: oral, a 10-30 milliliter, 2-3 time on the one, or follow the doctor's advice.
Embodiment 2
Antipyretic beverage:
Clean, dry raw material of Chinese medicine and consumption:
Fructus Momordicae 12 Flos Loniceraes 12 Semen Sterculiae Lychnophoraes 20 Herba Houttuyniae 25
Folium Perillae 30 Fructus Citri Sarcodactylis 10 Folium Mori 35
Method for making: above seven flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 16000ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, add an amount of sucrose dissolved, regulate pH value to 7.0, and adjust total amount to 10000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Embodiment 3
Capsule, pill, bag tea:
Clean, dry raw material of Chinese medicine and consumption:
Fructus Momordicae 12 Flos Loniceraes 12 Semen Sterculiae Lychnophoraes 20 Herba Houttuyniae 25
Folium Perillae 30 Fructus Citri Sarcodactylis 10 Folium Mori 35
Method for making: above seven flavor raw material of Chinese medicine are ground into fine powder, cross 120 mesh sieves, add proper amount of sugar or sucrose adjuvant, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, stir therebetween 3 times, each 10 minutes, heating extraction 1 hour, it is an amount of to collect concentrate, and cold preservation was placed 8-12 hour down, precipitation filters.Get concentrate and beat fine powder, or raw material is broken into fine powder, add appropriate amount of auxiliary materials.Encapsulated, the dress tea-bag, pill, and other goods, sterilization, packing, promptly.
Embodiment 4
Injection:
Clean, dry raw material of Chinese medicine and consumption:
Fructus Momordicae 12 Flos Loniceraes 12 Semen Sterculiae Lychnophoraes 20 Herba Houttuyniae 25
Folium Perillae 30 Fructus Citri Sarcodactylis 10 Folium Mori 35
Method for making: above seven flavor raw material of Chinese medicine are ground into coarse powder, cross sieve No. two, put into the extraction pot of band distillator, add water 1600ml, soaked 2 hours, and stirred therebetween 3 times, each 10 minutes, heating extraction 1 hour, the collection distillate is an amount of, and cold preservation was placed 8-12 hour down, and precipitation filters.
Get filtrate, regulate pH value to 7.0, and adjust total amount to 1000ml with sodium hydroxide.Embedding, sterilization, packing, promptly.
Embodiment 5
Clinical trial:
1. catch a cold
Flu patient 100 examples are comprehensively examined or check from clinical examination and three aspects of biopsy pathology; After treating a course of treatment, 32 routine patients' recoveries from illness are arranged, 36 routine patient's symptoms obviously alleviate, and 32 routine patients obviously do not improve; After treating two courses of treatment, 48 routine patients' recoveries from illness are arranged, 46 routine patient's symptoms obviously alleviate, and 6 routine patients obviously do not improve; After treating three courses of treatment, there are 58 routine patient's symptoms obviously to fully recover, 41 routine patients improve; 1 routine patient does not obviously improve.
2. have a fever
Flu band fever patient 100 examples, from clinical symptoms, scope differs from the examination of two each side; Controlling
After treating a course of treatment, 58 routine patient's recoveries from illness are arranged, 38 routine patient's symptoms obviously alleviate, and 4 examples are suffered from
The person does not improve; After treating two courses of treatment, 68 routine patients' recoveries from illness are arranged, 32 routine patient's symptoms
Obviously alleviate, 1 example is not improved; After treating three courses of treatment, 79 routine patients' recoveries from illness, 21 routine patient's symptoms obviously alleviate, and 0 example is not improved.
3. cough
Flu band cough patient 100 examples, single from clinical observation: after treating a course of treatment, 46 routine patient's recoveries from illness, 34 routine patient's symptoms obviously alleviate, and 20 examples are not improved; After treating for two each courses of treatment, 58 routine patients' recoveries from illness are arranged, 32 routine patient's symptoms obviously alleviate, and 10 examples are not improved;
After three courses of treatment, 94 example recoveries from illness, 6 routine patient's symptoms obviously alleviate.
Therapeutic Method:
The oral liquid group of Chinese medicine composition of the present invention: every day 2 times, each 1,3 is a course of treatment, intermittently begins for second course of treatment after 1～2 day, uses 2-3 courses of treatment.
The oral liquid combined group of Chinese medicine composition of the present invention: every day 2 times, each 1,3 is a course of treatment, intermittently begins for second course of treatment after 1～2 day, uses 2-3 courses of treatment.It is oral to shake up the back when taking.
Matched group: do not take the oral liquid of Chinese medicine composition of the present invention, only with treatment flu, fever, the conventional therapy medicine of cough, it is poor to improve resistance.
Discuss: the oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese herbal and crude drugs preparations, be from natural Chinese medicinal herb through the colourless transparent liquid of distillation extraction, have ventilation, antiinflammatory, bring down a fever,, be used for the treatment of diseases such as flu, fever, sore throat.
By observing oral liquid patients with gastric disease 300 examples with Chinese medicine composition of the present invention.Take effectively cough-relieving behind this medicine, bringing down a fever etc. all has in various degree raising.The oral liquid group total effective rate 97% of Chinese medicine composition of the present invention, the oral liquid mixed type group total effective rate 97% of Chinese medicine composition of the present invention.Cooperate original therapeutic scheme can improve the remission rate of common cold.Thereby improved remission rate.The oral liquid of Chinese medicine composition of the present invention is safe in utilization, have no side effect.
Embodiment 6
Model case exemplifies:
Case one: Zheng Hua: the man, 40 degree hyperpyrexias were not brought down a fever through hospitalization in 5 days, after taken Chinese herbal medicine of the present invention recovery from illness 1 course of treatment.
Case two: Wang Lisheng: the man, 19 years old, in July, 2006 was restive in Jinhua hospital 41 degree hyperpyrexias, people's comatose state, after took Chinese herb medicine of the present invention 2 days, sb.'s illness took a favorable turn, the 3rd day just can out-of-bed activity.
Case three: He Wang: man, 25 years old.Fever has cough, general weakness, the treatment of preparing to go to the hospital, take Chinese patent medicine of the present invention after, do not cough in the 3rd day, spirit takes a turn for the better, and has not just gone to the hospital.
Case four: Hong Xiaoqing, the woman, 27 years old,, treat in Jinhua City People because of the cough sore throat, cough does not end more than 7 days, prepare to change the treatment of Jinhua central hospital, took Chinese herb medicine of the present invention 3 days, every day 4 times before transferring from one hospital to another, the Jinhua central hospital check result of transferring from one hospital to another is with recovery from illness, and not being in hospital just directly leaves hospital has gone home to have had a rest.
Case five: Chen Lijuan: the woman, 24 years old, service man, because of the cough sore throat, all day cough, general weakness is taken in JIUYUE, 2007 and to be removed sore throat the same day, with fully recovering after three courses of treatment.
Case six: Shao Zhengfei: the man, 25 years old, the student of Normal University because of flu, took two rehabilitations course of treatment in December, 2007.
Case seven: Dong Junliang: the man, 26 years old, weak all over because of the flu nasal obstruction, take prescription nasal obstruction two courses of treatment of the present invention and disappear, it is normal to sleep.
Case eight: magnificent power: man: 23 years old, the student of Normal University, weak all over because of flu, take prescription of the present invention recovery from illness two courses of treatment.
Medicine of the present invention is taken the compound prescription of medicine-food two-purpose Chinese herbal medicine of the present invention through routine patients up to a hundred (comprising fever, cough, flu etc.) patient, reflects fine.
Embodiment 7
Acute toxicity test:
The oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese medicinal preparation, is the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, has ventilation, antiinflammatory, brings down a fever, ends sore throat, is used for the treatment of common colds such as flu, fever, sore throat and nasal obstruction.
Therefore, this medicine has been carried out acute toxicity test in mice, its acute toxicity test is reported as follows:
Choose 20 of NIH kind mices, ♀ ♂ half and half, body weight is 23.52 ± 2.20g (X ± S), press the dosage gastric infusion of 40ml/kg, one day twice, observed no abnormal phenomenon seven, do not have deadly, body weight increases to 27.57 ± 2.61g, and (X ± S) is than increasing weight 17.22% before the administration.
The oral liquid clinical medicine dose of Chinese medicine composition of the present invention is 5ml * 2=10ml every day, become body weight for humans by 60kg, then Cheng Ren oral dose is 10ml/60kg=0.167ml/kg, and mice dosage every day is 40 * 2=80ml/kg, and quite the 80/0.167=480 of people's consumption doubly.
The oral liquid formulations of Chinese medicine composition of the present invention is oral peace bottle, selects 10 of NIH kind mices, and with the dosage tail vein injection of every of 0.5ml, at the uniform velocity injection in 8-10 seconds was observed 72 hours, and no abnormal phenomenon does not have dead.
Result of the test shows: the oral liquid toxicity of Chinese medicine composition of the present invention is less.
Embodiment 8
Long term toxicity test:
The oral liquid of Chinese medicine composition of the present invention is a kind of pure Chinese medicinal preparation, is the colourless transparent liquid of process distillation extraction from natural Chinese medicinal herb, has ventilation, antiinflammatory, brings down a fever, ends sore throat, is used for the treatment of flu, fever, ends diseases such as sore throat, nasal obstruction.Test report is as follows:
Material and method
Experimental animal: 7-8 age in week health 60 of Wistar rats, male and female half and half are provided by Wenzhou Medical College's Experimental Animal Center.Observe a week before the test, adopt randomized blocks that rat is divided into three groups, 20 every group, male and female half and half, sub-cage rearing.Periodic logging rats eating amount is freely drunk water.Claim body weight weekly one time.
Tried thing and dosage: " oral liquid of Chinese medicine composition of the present invention " is the plurality of Chinese distillation extraction, the supernatant liquid of purification.
The dosage group is the requirement by acute toxicity testing result and new Chinese medicine toxicologic study guide, establishes two dosage groups of height and a matched group.High dose is 1200g/kg, is equivalent to 70 times of clinical application amount, and low dose group is 500g/kg, is equivalent to 30 times of clinical application amount.
Route of administration and method: adopt administration by gavage.Irritate body of stomach long-pending by body weight 1% wait not even depth administration of capacity.Every day 1 time, 6 days weekly, amounted to for 8 weeks.Press weekly body weight change during the administration and adjust dosage.
Observation index:
Ordinary circumstance: observe the outward appearance sign every day, behavioral activity, urine excrement situation, food-intake.Weigh weekly to observe and change.
Hematological examination: get 10 rats (male and female half and half) at random for every group, before administration, the 4th week and the 8th week after the administration, get blood at the tail vein, erythrocyte, leukocyte are tested by " national Clinical Laboratory rule of operation " requirement with indexs such as classification, platelet, reticulocyte and content of hemoglobin.
Blood biochemical is learned and checked: test proceeded to for the 4th week and the 8th week, in the blood vessel blood sampling of thigh portion, measured serum alanine transaminase (ALT), total bilirubin (T--BIL), blood urea nitrogen (BUN) and creatinine (CRE) four indices.
Rat is dissected and histopathologic examination: experiment finishes, get 10 rats (male and female half and half) for every group, thigh portion blood vessel sacrificed by exsanguination, the conventional dissection, observe the mode of appearance of each internal organs, color etc., and internal organs such as the heart, liver, spleen, lung, kidney, brain are weighed, calculate the percentage ratio of itself and body weight, i.e. organ coefficient.The pathology method is handled routinely then, the histopathologic examination of doing the heart, liver, spleen, lung, kidney, brain and femur.
Statistical procedures: adopt T check and F check.Data machine are as calculated handled.
The result:
General state and body weight change: during the administration, each treated animal general state, movable normal, the no abnormality seen reaction.Administration group and matched group food-intake are close substantially.Administration group and matched group body weight gain trend basically identical illustrate that long term administration do not have obvious influence to growth of animal.Male Mus or each administration group weight gain value of female Mus are compared with matched group, no significant difference (P〉0.05).
Hematological indices: rat hemogram check result is listed in table 1,2,3.Find out by table 1 and table 2, " oral liquid of Chinese medicine composition of the present invention " height, end dosage group erythrocyte, leukocyte and classification, platelet and content of hemoglobin be 4 week and 8 weeks before administration, after the administration, compare P with matched group〉0.05, illustrate that medicine does not have obvious influence to above-mentioned each index.
Blood biochemical is learned index: test proceeded to for the 4th week and the 8th week, in the blood vessel blood sampling of thigh portion, measured serum alanine transaminase (ALT), total bilirubin (T--BIL), and blood urea nitrogen (BUN) and creatinine (CRE) four indices the results are shown in table 3.
Organ weights: each organizes organ weights such as the heart, liver, spleen, lung, kidney, brain and organ coefficient is listed in table 4.
Histopathologic examination: off-test, rat is dissected, and does not find the obvious change of organs such as the heart, liver, spleen, lung, kidney, brain.Histopathologic examination does not find that pathological change is arranged yet, and shows that long term administration do not have obvious damage to each organs and tissues.
Brief summary:
Continuous 8 weeks pour into " oral liquid of herbal composite of the present invention " to rat oral, and dosage is 70 times and 30 times of clinical consumption, and the rat general state is good, no abnormal performance, and each organizes bodyweight difference does not have significance, and the rat normal growth is not had obvious influence.
Continuous 8 all administrations, the rat reticulocyte significantly increases (table 2), learns other indexs of liquid and changes not significantly (table 4), illustrate " oral liquid of Chinese medicine composition of the present invention " but hemopoietic function improvement.
" oral liquid of Chinese medicine composition of the present invention " the long term toxicity test result show, finds no pathological change (table 1).
Above result of the test shows, " oral liquid of Chinese medicine composition of the present invention " life-time service, and no overt toxicity is safe Chinese medicine preparation.
Table 1, " oral liquid of Chinese medicine composition of the present invention " long term toxicity test hemogram result (X ± S)
Table 2, " oral liquid of Chinese medicine composition of the present invention " are to the influence of reticulocyte (%, X ± S)
| Group | Number of animals | Before the administration | 4 weeks after the administration | 8 weeks after the administration | P |
| Contrast | 10 | 2.05±1.13 | 1.40±0.69 | 2.18±1.34 | |
| Low dosage | 10 | 1.93±1.17 | 2.13±1.07 | 6.75±1.35 | <0.01 |
| High dose | 10 | 2.11±1.12 | 2.21±0.91 | 7.07±1.91 | <0.01 |
| P | >005 | >005 | >005 |
Table 3, differential blood count result (%, X ± S)
Table 4, blood biochemical are learned index determining result (X ± S)
Table 5, respectively organize relatively (X ± S) of organ coefficient
Embodiment 9
The stability of product of the present invention: carry out repeatedly stability test at various products of the present invention.
Test comprises that high temperature quickens and room temperature is placed.Show that all product of the present invention has good stability.The oral liquid that shows one of product of the present invention embodiment 1 in the table 8 is at the steadiness of placing 18 months.
More than embodiments of the invention are had been described in detail, but described content only is preferred embodiment of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should still belong within the patent covering scope of the present invention.
Claims (4)
1. Chinese herbal medicine combined food series for the treatment of common cold, it is characterized in that comprising Fructus Momordicae, Flos Lonicerae, Semen Sterculiae Lychnophorae Herba Houttuyniae, compositions such as Folium Perillae, each component and weight ratio thereof are: Fructus Momordicae: Flos Lonicerae: Semen Sterculiae Lychnophorae: Herba Houttuyniae: Folium Perillae: Fructus Citri Sarcodactylis: Folium Mori=1-156:1-126:2-200:3-200:3-210:1-256:3--260 is made into capsule, pill, bag tea, oral liquid, antipyretic beverage, injection etc.
2. product of the present invention has flu, fever, sore throat or pharyngolaryngitis person, and the category treatment flu that also belongs to common cold has obvious effect.
3. product effective percentage of the present invention is 97%.
4. this prescription selects for use the Chinese medicine of medicine-food two-purpose to form.
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| CN114146142A (en) * | 2020-09-08 | 2022-03-08 | 北京德科瑞医药科技有限公司 | Mulberry leaf compound extract and preparation method and application thereof |
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| CN105641297A (en) * | 2016-01-22 | 2016-06-08 | 柳州易农科技有限公司 | Faucitis treating medicine containing momordica grosvenori |
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