CN101390963A

CN101390963A - Process method of aconite

Info

Publication number: CN101390963A
Application number: CNA200710018810XA
Authority: CN
Inventors: 廖德宏; 郝学贤; 沈文泉; 陈波; 范显丰; 甘志杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-09-17
Filing date: 2007-09-17
Publication date: 2009-03-25

Abstract

The invention discloses a preparation method of Chinese traditional medicine aconite root; the preparing process of black prepared lateral root of aconite includes that aconite root is firstly immersed in <Danpa> water solution; then the aconite root is washed by clean water to be vertically cut into slices with the thickness of approximate 0.5 cm; then the slices are steamed completely and rinsed by clean water, then the aconite root slices are dripped and dyed brown through toning solution; then the aconite root slices are steamed until an oil surface is formed and the aconite root slices have luster; finally, the aconite root slices are dried in the sun or dried under low temperature; the preparing process of white prepared lateral root of aconite includes that aconite root is firstly immersed in <Danpa> water solution; then the aconite root is taken out and peeled to be vertically cut into slices with the thickness of approximate 0.3 cm; the slices are steamed completely and rinsed by clean water, the aconite root slices are dripped and steamed until an oil surface is formed; finally, the aconite root slices are dried in sun or dried under low temperature. The preparing method enables the toxic ingredient aconitine in aconite root to hydrolyze sufficiently so that the application of the aconite root is safer; meanwhile, the total content of effective alkaloid in the aconite root products is maintained to be high and the efficacy is improved. Besides, the preparation method of Chinese traditional medicine aconite root has no environmental pollution and is applicable to industrialization production.

Description

The concocting method of Chinese medicine Radix Aconiti Lateralis Preparata

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to the concocting method of Chinese medicine Radix Aconiti Lateralis Preparata.

Background technology

The Chinese medicine Radix Aconiti Lateralis Preparata is the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Have cannon method, water to float Fa Heshui to the processed of Radix Aconiti Lateralis Preparata and float and increase temperature cooking process, Radix Aconiti Lateralis Preparata and Radix Aconiti Lateralis Preparata are exactly that water floats the processed product that increases temperature cooking process.

The method of concocting Radix Aconiti Lateralis Preparata at present is that Radix Aconiti Lateralis Preparata is clung to the aqueous solution soaking a few days with edible gallbladder, together with gallbladder crust liquid Radix Aconiti Lateralis Preparata is boiled to the saturating heart, be cut into the sheet of thick about 0.5cm behind the water rinse, the reuse water logging is floated, dye Umber with toning liquid, then it is steamed after pasta and gloss occur, baking is to half-dried, dries then or continues oven dry; The method of concocting Radix Aconiti Lateralis Preparata is that Radix Aconiti Lateralis Preparata is clung to the aqueous solution soaking a few days with eating gallbladder, together with gallbladder crust liquid Radix Aconiti Lateralis Preparata is boiled to the saturating heart, pulls out, peels off crust, the sheet of rip cutting Cheng Houyue 0.3cm, and the reuse water logging is floated, and takes out and steams thoroughly, dries at last.The concocting method of above-mentioned Radix Aconiti Lateralis Preparata and Radix Aconiti Lateralis Preparata is a kind of method of afterwards steaming of boiling earlier, and there is following drawback in it: 1. because Radix Aconiti Lateralis Preparata does not cut, in boiling process, aconitine is facile hydrolysis not, makes that the toxicity of Radix Aconiti Lateralis Preparata is bigger; Hydrolysis aconitine become the bigger hypaconitine of water solublity and mesaconitine and but stayed and be used as sewage in to boil water and be discharged, make that the effective alkaloid that has in the Radix Aconiti Lateralis Preparata reduces, reduced the curative effect of medicine again.2. because sewage emissions also causes certain pollution to environment.3. the time of each boiling Radix Aconiti Lateralis Preparata needed more than two hours, promptly used the bigger saucepan at every turn also can only the about 100 kilograms Radix Aconiti Lateralis Preparata of boiling, and its production efficiency is lower, and cost is also high, is not suitable for suitability for industrialized production.

Summary of the invention

The objective of the invention is to overcome deficiency of the prior art, propose a kind of concocting method of new Chinese medicine Radix Aconiti Lateralis Preparata.

The technical scheme that realizes above-mentioned purpose is:

(1) processing procedure of Radix Aconiti Lateralis Preparata Radix Aconiti Lateralis Preparata: earlier clean Radix Aconiti Lateralis Preparata is placed edible gallbladder crust aqueous solution to soak seven, pull Radix Aconiti Lateralis Preparata out, clear water is cleaned to noresidue gallbladder crust liquid; With the sheet of Radix Aconiti Lateralis Preparata rip cutting Cheng Houyue 0.5cm, steam to the saturating heart; Reuse clear water rinsing three days is changed water every day once, Radix Aconiti Lateralis Preparata is dyed dark brown with toning liquid behind the dewatering; Radix Aconiti Lateralis Preparata heating after the dyeing is steamed to going out pasta, have gloss after, Radix Aconiti Lateralis Preparata is spread out dried or oven drying at low temperature again.

(2) processing procedure of Radix Aconiti Lateralis Preparata Radix Aconiti Lateralis Preparata: earlier clean Radix Aconiti Lateralis Preparata is placed edible gallbladder crust aqueous solution to soak seven, pull Radix Aconiti Lateralis Preparata out, peel off crust; With the sheet of Radix Aconiti Lateralis Preparata rip cutting Cheng Houyue 0.3cm, to steam to the saturating heart, reuse clear water rinsing three days is changed water every day once, behind the dewatering Radix Aconiti Lateralis Preparata heating is steamed to going out pasta, at last Radix Aconiti Lateralis Preparata is dried or oven drying at low temperature.

The temperature of above-mentioned Radix Aconiti Lateralis Preparata oven drying at low temperature is 55～65 ℃.

The present invention adopts is to steam process twice.At first be to carry out steaming the first time after radix aconiti lateralis is cut into slices, make wherein fully hydrolysis of toxic component aconitine, the medication meeting is safer, although have some aconitines to be hydrolyzed into the hypaconitine and the mesaconitine of solubility in the process for the first time steaming, because quantity of steam is less than amount to boil water far away, therefore, there is the effective alkaloid dissolving few, what run off is also just few, and effective alkaloidal total amount still keeps very highly in the Radix Aconiti Lateralis Preparata, can improve drug effect.Moreover the present invention emits no waste water in steaming process substantially, does not therefore have sewage discharge, does not also just have the pollution to environment.In addition, the present invention changes boiling for steaming, and not only can improve production capacity, and suitability for industrialized production preferably helps the raising of production efficiency.

Detect according to two kinds of finished products of the aconitine limit detection method under the Pharmacopoeia of the People's Republic of China 2005 editions (an one) the Radix Aconiti Lateralis Preparata item after to the old and new's processes, two kinds of finished products all meet the pharmacopeia regulation; Adopt titrimetry to detect the Aconitum carmichjaelii Debx. total alkaloid content of two kinds of Radix Aconiti Lateralis Preparata finished products, the result is as follows:

Prior art is boiled earlier and is afterwards steamed technology Radix Aconiti Lateralis Preparata total alkaloids content before and after processing:

Project	Before the processing	After the processing
Project	Before the processing	After the processing	Test data 1	1.155％	0.172％
Test data 2	1.153％	0.174％	Test data 1	1.155％	0.172％
Test data 2	1.153％	0.174％	Average data	1.154％	0.173％

The present invention steams technology Radix Aconiti Lateralis Preparata total alkaloids content before and after processing for twice:

Project	Before the processing	After the processing
Project	Before the processing	After the processing	Test data 1	1.153％	0.969％
Test data 2	1.156％	0.975％	Test data 1	1.153％	0.969％
Test data 2	1.156％	0.975％	Average data	1.155％	0.972％

Annotate: above-mentioned test data 1 is two parallel samples with test data 2.

In the Radix Aconiti Lateralis Preparata decoction pieces course of processing, compare at semi-finished product after adopting the inventive method to steam for the first time and the semi-finished product after the prior art boiling, promptly use titrimetry and high performance liquid chromatography as follows effective total alkaloids of sample and aconitine detection by quantitative result:

Numbering	Total alkaloid content	Aconitine content
Numbering	Total alkaloid content	Aconitine content	1#	3.542mg/g	0.038mg/ml
2#	3.538mg/g	0.040mg/ml	1#	3.542mg/g	0.038mg/ml
2#	3.538mg/g	0.040mg/ml	Meansigma methods	3.540mg/g	0.039mg/ml
3#	3.667mg/g	0.052mg/ml	Meansigma methods	3.540mg/g	0.039mg/ml
3#	3.667mg/g	0.052mg/ml	4#	3.669mg/g	0.056mg/ml
Meansigma methods	3.668mg/g	0.054mg/ml	4#	3.669mg/g	0.056mg/ml
Meansigma methods	3.668mg/g	0.054mg/ml	5#	4.436mg/g	0.032mg/ml
6#	4.422mg/g	0.028mg/ml	5#	4.436mg/g	0.032mg/ml
6#	4.422mg/g	0.028mg/ml	Meansigma methods	4.429mg/g	0.030mg/ml

Annotate: 1#, 2# are two parallel samples of the close exocuticle part of Radix Aconiti Lateralis Preparata after the boiling of employing prior art; 3#, 4# are two parallel samples at above-mentioned same Radix Aconiti Lateralis Preparata sample heart position; 5#, 6# are two parallel samples that adopt after the inventive method steams for the first time.

From top testing result as can be seen, the concocting method of Chinese medicine Radix Aconiti Lateralis Preparata of the present invention not only helps the hydrolysis of aconitine, and helps the reservation of effective total alkaloids, so improved the quality of product.

The specific embodiment

The present invention is further described below in conjunction with embodiment.

Embodiment 1, the Radix Aconiti Lateralis Preparata processing instance:

Get 1000 kilograms of mud Radix Aconiti Lateralis Preparatas of uniform size, put in the clear water, clean up, make it not have silt and other foreign material; Cleaned Radix Aconiti Lateralis Preparata bubble in the gallbladder crust liquid with 1:1, was soaked 7 days; Pull the radix aconiti lateralis that soaks out, to the not residual gallbladder crust of radix aconiti lateralis, then the sheet of Radix Aconiti Lateralis Preparata rip cutting Cheng Houyue 0.5cm, place food steamer to steam 1-2 hour with the clear water rinsing, to the saturating heart, take out Radix Aconiti Lateralis Preparata, rinsing is three days in clear water, changes water every day once; The Radix Aconiti Lateralis Preparata of the good water of rinsing is dyed Radix Aconiti Lateralis Preparata with toning liquid dark brown, is placed food steamer to steam 6-8 hour once more, steam to going out pasta, have gloss after, take out and dry or the low temperature oven dry down in T=60 ± 5 ℃, 302 kilograms altogether of Radix Aconiti Lateralis Preparata.

Embodiment 2, the Radix Aconiti Lateralis Preparata processing instance:

Get 1000 kilograms of mud Radix Aconiti Lateralis Preparatas of uniform size, put in the clear water, clean up, make it not have silt and other foreign material; Cleaned Radix Aconiti Lateralis Preparata bubble in the gallbladder crust liquid with 1:1, was soaked 7 days; Pull the radix aconiti lateralis that soaks out, to the not residual gallbladder crust of radix aconiti lateralis, then the thin slice of Radix Aconiti Lateralis Preparata rip cutting Cheng Houyue 0.3cm, place food steamer to steam 1-2 hour with the clear water rinsing, to the saturating heart, take out Radix Aconiti Lateralis Preparata, rinsing is three days in clear water, changes water every day once; The Radix Aconiti Lateralis Preparata that will float water places food steamer to steam 6-8 hour once more, steams to going out pasta, dry after the taking-up or the low temperature oven dry down in T=60 ± 5 ℃, 260 kilograms altogether of Radix Aconiti Lateralis Preparatas.

Claims

1. the concocting method of a Chinese medicine Radix Aconiti Lateralis Preparata is characterized in that:

2. according to the concocting method of the described a kind of Chinese medicine Radix Aconiti Lateralis Preparata of claim 1., it is characterized in that: the temperature of described Radix Aconiti Lateralis Preparata oven drying at low temperature is 55～65 ℃.