CN101366448A - Environment-friendly acidulant - Google Patents
Environment-friendly acidulant Download PDFInfo
- Publication number
- CN101366448A CN101366448A CNA2007100757670A CN200710075767A CN101366448A CN 101366448 A CN101366448 A CN 101366448A CN A2007100757670 A CNA2007100757670 A CN A2007100757670A CN 200710075767 A CN200710075767 A CN 200710075767A CN 101366448 A CN101366448 A CN 101366448A
- Authority
- CN
- China
- Prior art keywords
- environment
- friendly
- acidulant
- acid
- urease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to the technical field of a feed additive, which discloses an environment-friendly acidifier. The environment-friendly acidifier comprises the following components in weight portion: 10 to 50 portions of phosphoric acid, 1 to 50 portions of organic acid, 30 to 50 portions of excipient, 1 to 10 portions of micro-ecology preparation inhibiting growth of microbes generating urease and pathogenic microbes, and 0.1 to 1 portion of urease inhibitor. The acidifier can lower the ammonia concentration in a stock raising farm to a large extent, prevent ammonia poisoning of animals, protect respiratory tract mucous membranes from being hurt, improve the immunization barrier function of mucous membrane, reduce the risk of infecting pathogenic germs, ensure the effective acidification of the whole gstrointestinal tracts of animals, inhibit pathogenic germs such as coliform bacteria, salmonella bacteria, streptococcus, and the like, and provide a suitable living environment for useful bacteria such as lactic acid bacteria, and the like.
Description
Technical field
The present invention relates to the feed additive, relate in particular to a kind of environment-friendly acidulant.
Background technology
In the place of letting animals feed, the generation of ammonia has become an important environmental problem.Its main source comprises: animal body protein metabolism product uric acid, urea are decomposed generation ammonia and carbon dioxide by the urase of bacterium and other microorganism secretions in enteron aisle, and 75% ammonia decomposes generation by bacterium in the enteron aisle in the enteron aisle.Secondly, the amino acid that produces in the animal body protein metabolism process is the main source of blood ammonia through the ammonia that various deaminations and kidney generate the glutamine hydrolysis, and very fast quilt detoxified after blood ammonia entered liver, urea synthesis, and discharge with urine.The uric acid that excretes, urea produce ammonia through the urase effect of bacterium and other microorganisms.In addition, the animal wastes that excrete also contain a large amount of protide nutrition of not decomposing fully, absorbing, and also can produce a large amount of ammonias after being utilized by external microorganism.In addition, also may there be urase in the feed, can causes the generation of ammonia equally.Ammonia not only can be sucked in the lung by livestock and poultry, enters blood, causes many negative effects, also is one of principal element that causes plant's environmental pollution simultaneously.
Ammonia mainly is negative to the influence of pig.When ammonia is accumulated to finite concentration in plant's air (particularly cold season), except that destroying the animal gastrointestinal tract mucous membrane, it can also cause domestic animal respiratory tract and ocular damage, destroys the mucosal immunity barrier, has increased the risk that pathogenic microorganisms (virus, bacterium and fungi etc.) infects.Ammonia also is to cause atrophic rhinitis or the bronchitic important co-factor of region.In addition, ammonia is also relevant with some abnormal behaviours of pig, for example autotomy.Animal Behavior Science studies show that under the situation of condition permission, pig can select not have the place that ammonia pollutes.The ammonia of high concentration is unfavorable for the growth of animal.Therefore reduce or reduce the generation of ammonia, to improving breed efficient and animal health level all at positive effect.
Adding acidulant in animal especially pig and poultry feed is widely adopted.Traditional acidulant is inorganic acid, single or compound organic acid and organic acid salt, and the mixture of excipient.Its effect and function mainly are: reducing feed is sour power, and reduces the pH value of gastrointestinal content; Improve and the normal microbial bacteria group structure of stable intestines and stomach, suppress the field planting of invasive organism, thereby keep intestines and stomach health; Improve food conversion ratio, reduce the generation of diarrhoea.But this class acidulant can not effectively reduce the content of ammonia in the environment.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of multi-functional acidulant is provided, except that the result of use that plays common acidulant, can also reduce effectively and culture the place ammonia level, realize acidizing effect, animal health and improve the unification of environment triple effect.
The technical scheme that realizes above purpose is:
A kind of environment-friendly acidulant, it is characterized in that comprising the component of following quality proportioning: 0～50 part of phosphatase 11,1～50 part of organic acid and its esters, 30～50 parts of excipient, 1～10 part of the probiotics of the microorganism of inhibition urease-producing and pathogenic microorganism growth, 0.1～1 part of urease inhibitor.
In a kind of optimized technical scheme, the probiotics of the microorganism of described inhibition urease-producing and pathogenic microorganism growth is one or more compound formulations of lactic acid bacteria, Bifidobacterium, acetic acid bacteria, butyric or the bacillus subtilis bacterial cell and the fermentating metabolism product of deactivation.
In a kind of optimized technical scheme, described urease inhibitor is the divalent salts of manganese, barium, cobalt, copper, iron, magnesium or one or more the mixture in the silver-colored monovalent salt.
In a kind of preferred technical scheme, described divalent salts or monovalent salt are phosphate or other soluble-salts.
In a kind of optimized technical scheme, described urease inhibitor is a hydroxamic acid.
In a kind of preferred technical scheme, described urease inhibitor is acetohydroxamic acid or caprylhydroxamic acid or its mixture.
In a kind of optimized technical scheme, described urease inhibitor is diamines or triamine.
In a kind of preferred technical scheme, described urease inhibitor is the phenyl phosphoryl diamine.
In a kind of preferred technical scheme, described urease inhibitor is for being N-butyl D2EHDTPA triamide or hexamethylene phosphoric triamide.
In a kind of optimized technical scheme, described urease inhibitor is the chicken yolk antibody of antiurease.
Acidulant of the present invention can be prepared according to existing preparation method commonly used.Liquid acid or its esters mixing earlier such as lactic acid, formic acid, acetate, propionic acid and butyric acid, mix after adding phosphoric acid, add solid organic acid such as fumaric acid, citric acid again, add precipitated silica then, fully stirring is fully adsorbed acid blend, then adds urease inhibitor, adds the probiotics that suppresses urease-producing microorganism and pathogenic microorganism growth at last, fully stir, packing gets final product at last.
Acidulant of the present invention; microbial activity stops amino acid whose deamination in animal gastrointestinal tract or the environment by suppressing; the activity that perhaps suppresses urase in animal or the environment stops uric acid, urea to be converted to be ammonia and carbon dioxide; therefore can reduce the concentration of animal-breeding place ammonia largely; prevent that the animal ammonia poisoning from reaching; the respiratory mucosa that watches for animals is avoided infringement, improves the mucosal immunity barrier function, reduces the risk of pathogenic microorganism infection.Acidulant of the present invention in addition can guarantee that the whole intestines and stomach of animal obtains effective acidifying, and can press down pathogenic bacteria such as killing Escherichia coli, salmonella, streptococcus, and the suitable living environments of probio such as lactic acid bacteria are provided.
The specific embodiment
The active ingredient that plays acidization among the present invention is phosphoric acid and organic acid.Organic acid optimization citric acid, lactic acid, fumaric acid, malic acid, formic acid, acetate, propionic acid and butyric acid, and organic acid salt in one or more.Citric acid is colourless translucent crystallization or white particle, or white crystalline powder, and is very effective to the Escherichia coli that reduce in stomach, colon, the rectum.Lactic acid is colourless or light yellow thick liquid, is one of glucolytic end product, can be used as the source of energy in particular cases.Fumaric acid also claims fumaric acid, is a kind of essential material of tricarboxylic acid cycle, stress with state of necessity under be used for the urgent synthetic of ATP.Formic acid, acetate, propionic acid and butyric acid and its esters are inhibited to the growth of animal intestinal and environmental microorganism.Formic acid is that outward appearance is a colourless transparent liquid, and it is very fast that formic acid can impel the pH value of feed starting stage to descend, thereby is the suitable condition of growth creation of lactic acid bacteria, improves the output of lactic acid, suppresses the growth of other assorted bacterium, gets rid of or reduced the harm of pernicious bacteria.
Excipient of the present invention can be selected precipitated silica for use, preferably uses 60-100 purpose precipitated silica.
The lactic acid bacteria of deactivation, Bifidobacterium, acetic acid bacteria, butyric or bacillus subtilis bacterial cell and fermentating metabolism product, wherein one or more compound preparations can suppress to secrete the bacterium of urase and the growth of other pathogenic microorganisms, thereby can suppress the generation of urase.Operable lactic acid bacteria and Bifidobacterium comprise lactobacillus (Lactobacillus spp.), galactococcus (Lactococcus spp.), streptococcus lactis (Streptococcus lactis), Bifidobacterium (Bifidobacter spp.); Operable acetic acid bacteria such as Pasteur's acetobacter (Acetobacterpasteurianus); Operable butyric such as clostridium butyricum (Clostridium butyricum).By microbial fermentation engineering and downstream technology, above-mentioned bacterial classification is fermented respectively, be mixed with the compound formulation of one or more microbial inoculums afterwards, vacuum concentrates and deactivation, obtain a kind of concentrated tunning, effective ingredient comprises the bacterial cell and the metabolite of deactivation.
Salt is as Mn
2+, Ba
2+, Co
2+, Cu
2+, Fe
2+, Mg
2+, Ag
+Salt can make the activated centre of urase and the structure of urase change, and has lost ureaclastic ability, has reduced effective urase concentration, thereby has suppressed the decomposition of urea, and using dosage is a trace, preferred manganese, copper, magnesium and molysite, especially preferred its phosphate.
Hydroxamic acid compounds such as acetohydroxamic acid (Acetohydroxamic acid, AHA) and caprylhydroxamic acid (Caprylohydroxamic acid, CHA), (NHOH), its active Hydrogen Energy on nitrogen-atoms plays the effect that suppresses urease activity to have the azanol structure in its molecule.
N-butyl D2EHDTPA triamide (N-6-butyl-thiophosporic tyiamide, NBPT), hexamethylene phosphoric triamide (Cyclo-hexylphos-phoryl triamide, CHPT) and phenyl phosphoryl diamine (Phenylphosphordiamidate, PPDA), it is the analogue of a class urea, the activity that can suppress urase competitively, the hydrolysis rate of reduction urase.
Chicken yolk antibody (Immunoglobulin yolk, IgY), can with urase generation neutralization reaction, its preparation process is: the fusion expressed product that at first obtains microorganism urease by the method for genetic engineering and Fermentation Engineering, add proper adjuvant afterwards and make vaccine, the immunity bird inlay is collected yolk then, makes the IgY that contains antiurease by absorption and drying means.
Below with embodiment the present invention is described, but embodiment does not constitute any limitation of the invention.
Example 1
A kind of environment-friendly acidulant, its each component is (per kilogram): phosphoric acid 500 grams, citric acid 10 grams, lactic acid 14 grams, fumaric acid 15 grams, formic acid or salt 10 grams, specification is 80 purpose precipitated silicas, 350 grams, Lemonal 100 grams of deactivation, wherein the lactobacillus cell content of deactivation is 〉=10
8Individual/g, manganese phosphate 0.5 gram, cupric phosphate 0.5 gram.Consumption in one ton of complete diet pellet is the 1-3 kilogram.
Example 2
A kind of environment-friendly acidulant, its each component and consumption thereof are (per kilogram): phosphatase 11 00 gram, citric acid 34 grams, lactic acid 346 grams, fumaric acid 34 grams, formic acid 86 grams, specification is 60 purpose precipitated silicas, 340 grams, the galactococcus of deactivation and acetic acid bacteria compound formulation 50 gram, wherein as killed cells content 〉=10
8Individual/g, ferric phosphate 10 grams.Use amount in one ton of complete diet pellet is the 1-3 kilogram
Example 3
A kind of environment-friendly acidulant, its each component and consumption are (per kilogram): phosphoric acid 304 grams, citric acid 5 grams, lactic acid 280 grams, fumaric acid 5 grams, specification is 100 purpose precipitated silicas, 351 grams, the clostridium butyricum of deactivation and bacillus subtilis compound formulation 50 gram, wherein as killed cells content 〉=10
8Individual/g, acetohydroxamic acid 2.5 grams, butyl D2EHDTPA triamide 2.5 grams.Complete diet pellet per ton uses the 1-3 kilogram.
Example 4
A kind of environment-friendly acidulant, its each component and consumption are (per kilogram): phosphoric acid 230 grams, citric acid 13 grams, lactic acid 206 grams, fumaric acid 13 grams, formic acid 68 grams, specification is 80 purpose precipitated silicas, 450 grams, the lactobacillus of deactivation and bifidobacterium preparations 19 gram, wherein as killed cells content 〉=10
8Individual/g, chicken yolk antibody 1 gram.Use the 1-3 kilogram in the complete diet pellet per ton.
Below be the present invention to be described at animal-breeding field embodiment
Place: certain boar plant of the north;
Experimental period: 13 days, summer;
Experiment combination: the foregoing description 4 experiments and the control group that does not add environment-friendly acidulant;
Experimental subjects: 60 age in days pigs, in two large-scale production line growth pig houses, experimentize, the stocking density of two pig houses is close, and corresponding is embodiment 4 and control group respectively;
Experimental technique: what pig house was taked is the semi open model layout, and any ventilation unit is not established in the inside.Before adding environment-friendly acidulant, in house, layout for three days on end and get air sample, measure ammonia concentration, and gather pig urine and ight soil mensuration total ammonia (TN) and ammoniacal nitrogen (NH wherein every day
3-N); Then add 0.1% environment-friendly acidulant and begin to feed in feed, opening entry data for three days on end after 10 days are added acidulant and are finished up to experiment;
Experimental data: pig house ammonia concentration, the variation of total ammonia and ammonia nitrogen in pig urine, the ight soil;
Data are summed up:
Table 1 adds the content (mg/m of ammonia in the preceding pig house air of environment-friendly acidulant
3)
Table 2 adds environment-friendly acidulant content (mg/m of ammonia in the pig house air after ten days
3)
The variation (g/L) of total ammonia and ammoniacal nitrogen during pig urinates before and after the table 3 interpolation environment-friendly acidulant
The variation (g/kg) of total ammonia and ammoniacal nitrogen in the swine excrement of table 4 interpolation environment-friendly acidulant front and back
Sum up: experimental data shows, in feed, add environment-friendly acidulant after, can effectively reduce airborne ammonia concentration in the pig house, and can reduce the content of total ammonia and ammoniacal nitrogen in the pig urine, but little total ammonia in the swine excrement and ammoniacal nitrogen influence; But the ammonia in the animal house mainly is to come from urine, small part is only arranged from ight soil, moreover for pig, nitrogen in the ight soil only accounts for 33% of total nitrogen in the fecaluria, so the variation of the total nitrogen content in the urine is one of this acidulant important evidence that whether " environmental protection " effect is arranged.Breed person's feedback information: compare with the control group pig house that does not add environment-friendly acidulant, in the pig house of interpolation environment-friendly acidulant, air ambient is better, and pig abnormal behaviour does not appear in the not pungent and dazzling discomfort sensation that waits.
Claims (10)
1. environment-friendly acidulant, it is characterized in that comprising the component of following quality proportioning: 0～50 part of phosphatase 11,1～50 part of organic acid, 30～50 parts of excipient, 1～10 part of the probiotics of the microorganism of inhibition urease-producing and pathogenic microorganism growth, 0.1～1 part of urease inhibitor.
2. environment-friendly acidulant according to claim 1 is characterized in that: the probiotics of the microorganism of described inhibition urease-producing and pathogenic microorganism growth is one or more compound formulations of lactic acid bacteria, acetic acid bacteria, butyric or the bacillus subtilis bacterial cell and the fermentating metabolism product of deactivation.
3. environment-friendly acidulant according to claim 1 is characterized in that: described urease inhibitor is one or more the mixture in the monovalent salt of the divalent salts of manganese, barium, cobalt, copper, iron, magnesium or silver.
4. environment-friendly acidulant according to claim 3 is characterized in that: described divalent salts or monovalent salt are phosphate or other soluble-salts.
5. environment-friendly acidulant according to claim 1 is characterized in that: described urease inhibitor is a hydroxamic acid.
6. environment-friendly acidulant according to claim 5 is characterized in that: described urease inhibitor is acetohydroxamic acid or caprylhydroxamic acid or its mixture.
7. environment-friendly acidulant according to claim 1 is characterized in that: described urease inhibitor is diamines or triamine.
8. environment-friendly acidulant according to claim 7 is characterized in that: described urease inhibitor is the phenyl phosphoryl diamine.
9. environment-friendly acidulant according to claim 7 is characterized in that: described urease inhibitor is N-butyl D2EHDTPA triamide or hexamethylene phosphoric triamide.
10. environment-friendly acidulant according to claim 7 is characterized in that: described urease inhibitor is the chicken yolk antibody of antiurease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100757670A CN101366448A (en) | 2007-08-15 | 2007-08-15 | Environment-friendly acidulant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100757670A CN101366448A (en) | 2007-08-15 | 2007-08-15 | Environment-friendly acidulant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101366448A true CN101366448A (en) | 2009-02-18 |
Family
ID=40410565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100757670A Pending CN101366448A (en) | 2007-08-15 | 2007-08-15 | Environment-friendly acidulant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101366448A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971921A (en) * | 2010-11-12 | 2011-02-16 | 胡文锋 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
| CN102910791A (en) * | 2012-10-16 | 2013-02-06 | 青岛根源生物技术集团有限公司 | Micro ecological additive and application thereof in reducing ammonia emission |
| CN107712313A (en) * | 2017-10-30 | 2018-02-23 | 漳州傲农牧业科技有限公司 | A kind of feeding compound acidulant and its preparation method and application |
| CN109463087A (en) * | 2018-11-30 | 2019-03-15 | 淮阴师范学院 | A kind of modification method of farmland acidified soil |
| CN109566878A (en) * | 2018-12-25 | 2019-04-05 | 乐山市瑞和祥动物保健药业有限公司 | A kind of compound acidulant sustained release pellet and preparation method thereof |
| DE102019201159A1 (en) | 2019-01-30 | 2020-07-30 | Skw Stickstoffwerke Piesteritz Gmbh | Highly effective concentrates with PPDA and their use to stabilize the valuable substances in animal excrement |
| CN115644325A (en) * | 2022-11-11 | 2023-01-31 | 中国科学院水生生物研究所 | Low-carbon feed for pelteobagrus fulvidraco and preparation method thereof |
-
2007
- 2007-08-15 CN CNA2007100757670A patent/CN101366448A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971921A (en) * | 2010-11-12 | 2011-02-16 | 胡文锋 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
| CN101971921B (en) * | 2010-11-12 | 2013-05-08 | 胡文锋 | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof |
| CN102910791A (en) * | 2012-10-16 | 2013-02-06 | 青岛根源生物技术集团有限公司 | Micro ecological additive and application thereof in reducing ammonia emission |
| CN107712313A (en) * | 2017-10-30 | 2018-02-23 | 漳州傲农牧业科技有限公司 | A kind of feeding compound acidulant and its preparation method and application |
| CN109463087A (en) * | 2018-11-30 | 2019-03-15 | 淮阴师范学院 | A kind of modification method of farmland acidified soil |
| CN109463087B (en) * | 2018-11-30 | 2021-03-23 | 淮阴师范学院 | Method for improving farmland acidified soil |
| CN109566878A (en) * | 2018-12-25 | 2019-04-05 | 乐山市瑞和祥动物保健药业有限公司 | A kind of compound acidulant sustained release pellet and preparation method thereof |
| DE102019201159A1 (en) | 2019-01-30 | 2020-07-30 | Skw Stickstoffwerke Piesteritz Gmbh | Highly effective concentrates with PPDA and their use to stabilize the valuable substances in animal excrement |
| EP3689885A1 (en) | 2019-01-30 | 2020-08-05 | SKW STICKSTOFFWERKE PIESTERITZ GmbH | Highly effective concentrates with ppda and their use in stabilizing materials in animal excrements |
| CN115644325A (en) * | 2022-11-11 | 2023-01-31 | 中国科学院水生生物研究所 | Low-carbon feed for pelteobagrus fulvidraco and preparation method thereof |
| CN115644325B (en) * | 2022-11-11 | 2024-01-05 | 中国科学院水生生物研究所 | Low-carbon feed for pelteobagrus fulvidraco and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104171690B (en) | A kind of feed addictive for the deodorizing of pig house mosquito repellent | |
| CN103535323B (en) | The aquaculture model of a kind of livestock and poultry | |
| US10821093B2 (en) | Antibacterial microelement chelates and the use thereof in animal feeds | |
| CN101366448A (en) | Environment-friendly acidulant | |
| CN103766604B (en) | A kind of preparation of composite probiotics preparations | |
| CN103598483B (en) | A kind of reduce piglet stress additive for microbe feedstuff and preparation method thereof | |
| CN109601738A (en) | A kind of drinking water type acidulant and its preparation method and application | |
| CN104814276A (en) | Biological deodorant for animal feeding | |
| CN105876131B (en) | Compound deodorant for livestock and poultry houses | |
| WO2007072848A1 (en) | Microbial preparation for reducing greenhouse gas excreted from livestock or fowl | |
| CN1692797A (en) | Acidization agent composite using L-lactic acid as main component, and use thereof | |
| RU2378869C1 (en) | Method for reduction of hazardous admixtures content in poultry yard air | |
| CN110923170A (en) | Composite microecological preparation for three-dimensional epidemic prevention of nonreactive breeding of live pigs and preparation method and application thereof | |
| CN108338277A (en) | A kind of pet stomach is good for the preparation method of additive for microbe feedstuff | |
| CN108464246A (en) | A kind of salt-soda soil cowboying fermenting bed padding adjusting control agent | |
| CN107960543B (en) | Glycine-type additive premix feed for piglets | |
| CN115669803A (en) | Micro-ecological feed capable of improving intestinal health and deodorizing and preparation method thereof | |
| CN101411319B (en) | Ecological method for feeding pigs with low discharging | |
| CN108041299B (en) | Antibiotic-free piglet compound feed | |
| CN113136353A (en) | Microbial preparation and application thereof | |
| CN108185122A (en) | A kind of additive for microbe feedstuff for enhancing immunity of livestock | |
| CN108077593B (en) | Antibiotic-free piglet concentrated feed | |
| CN109430521A (en) | A kind of compound feeding micro-ecological preparation and preparation method thereof | |
| CN105454154A (en) | High-efficiency pollution-free live pig breeding method | |
| CN104664048A (en) | Microbial addictive capable of improving nutritive value of feed |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20090218 |