CN101360703B - Process for the preparation of amines - Google Patents

Process for the preparation of amines Download PDF

Info

Publication number
CN101360703B
CN101360703B CN200680051127XA CN200680051127A CN101360703B CN 101360703 B CN101360703 B CN 101360703B CN 200680051127X A CN200680051127X A CN 200680051127XA CN 200680051127 A CN200680051127 A CN 200680051127A CN 101360703 B CN101360703 B CN 101360703B
Authority
CN
China
Prior art keywords
compound
general formula
reductive agent
formula
implication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200680051127XA
Other languages
Chinese (zh)
Other versions
CN101360703A (en
Inventor
H·托布勒
H·沃尔特
C·科尔西
J·埃伦弗罗因德
F·焦尔达诺
M·泽勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of CN101360703A publication Critical patent/CN101360703A/en
Application granted granted Critical
Publication of CN101360703B publication Critical patent/CN101360703B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/23—Preparation of halogenated hydrocarbons by dehalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/30—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by a Diels-Alder synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/60—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton containing a ring other than a six-membered aromatic ring forming part of at least one of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/61—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton with at least one of the condensed ring systems formed by three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catalysts (AREA)

Abstract

The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R<1> and R<2> are independently H or C1-6 alkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein R<1> and R<2> have the meanings given for the compound of the formula (I), R<3> is H or C1-4alkyl and Ph is phenyl, or a compound of the general formula (III), wherein R<1>, R<2>, R<3> and Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R<3>)- from the benzylamino moiety PhCH(R<3>)NH- in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2, 3-double bond and the double bond joining the R<1>R<2>C- moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides.

Description

The preparation method of amine
The present invention relates to a kind of novel method that is used to prepare some 5-amino-benzo norbornylene, and they are used to prepare the purposes of carboxylic acid benzo norbornene-acid amides, said carboxylic acid benzo norbornylene can be used as microbiocide, especially as mycocide.
Described multiple heterocyclic radical-carboxylic acid benzo norbornylene-5-base-acid amides among the WO 04/035589, their preparation method and they are as the purposes of microbiocide.According to 04/035589, these acid amides can prepare described in following scheme 1.
Scheme 1:
Figure S200680051127XD00011
In synthetic shown in the scheme 1, the 3-nitro-benzyne that produces by 6-nitro anthranilic acid (A) at first in the Diels-Alder reaction with ring 1,4-diene (B), for example 5-sec.-propyl-cyclopentadiene reaction, thereby form 5-nitro-benzo norbornadiene (C).Under the catalytic reduction condition of standard, (for example, use solvent for example to draw Buddhist nun's nickel or palladium carbon in the methyl alcohol), the 5-nitro and 2 on 5-nitro-benzo norbornadiene (C), the two keys of 3-all are reduced, thereby have formed 5-amino-benzo norbornylene (D).5-amino-benzo norbornylene (D) and heterocyclic radical-carboxylic acid or heterocyclic radical-carboxylic acid derivative (E) solvent for example in the methylene dichloride reaction obtain Fungicidal heterocyclic base-carboxylic acid benzo norbornylene-5-base acid amides (F), the Q in (E) can be hydroxyl, fluorine, chlorine or bromine.(D) a example is 5-amino-9-sec.-propyl-benzo norbornylene, and it is the precursor of acid amides, and said acid amides for example is 3-difluoromethyl-1-methyl isophthalic acid H-pyrazoles-4-carboxylic acid.
The problem that exists in 1 described synthesizing in scheme is to have formed many isomer impurities of not expecting.For example, through Diels-Alder prepared in reaction 5-nitro-benzo norbornadiene (C) time, R wherein 4, R 5, R 6And R 7All be that H and Y are-the CH-sec.-propyl, formed following positional isomers:
Figure S200680051127XD00021
Unfortunately, the isomer C of expectation 1Be to form with low relatively productive rate.Though can when the Diels-Alder reaction finishes or in the more late stage, the technology through routine perhaps undesirable isomer be removed through chromatographic process; But this synthetic route is not to be well suited for large-scale production, and described common process for example is fractional crystallization or fractionation.
Method of the present invention provides a kind of solution to this problem, and it can prepare 5-amino-benzo norbornylene (D) with good productive rate and quality with favourable economically mode.
Therefore, according to the present invention, the preparation method of a kind of general formula (I) compound is provided:
Figure S200680051127XD00022
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprise with reductive agent handles general formula (II) compound:
Figure S200680051127XD00031
R wherein 1And R 2Has given implication in formula (I) compound, R 3Be H or C 1-4Alkyl, and Ph is phenyl, perhaps
Handle general formula (III) compound:
Figure S200680051127XD00032
R wherein 1, R 2, R 3Have given implication in formula (II) compound with Ph, said reductive agent makes phenmethyl part Ph-CH (R effectively 3The amino part PhCH of the phenmethyl of)-from formula (II) compound or formula (III) compound (R 3) the last cracking of NH-, thereby stay amino, in addition, for formula (III) compound, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound.
Each straight or branched naturally of moieties; And contain 1 to 4 or 1 to 6 carbon atom according to it; It for example is methyl, ethyl, n-propyl, normal-butyl, n-pentyl, n-hexyl, sec.-propyl, sec.-butyl, isobutyl-, the tertiary butyl, neo-pentyl, n-hexyl or 1,3-dimethylbutyl.
R 1And R 2Be H or C independently 1-6Alkyl.They can be that H or one can be H and another is C simultaneously 1-6Alkyl, perhaps they can be identical or different alkyl simultaneously.Interested especially is R 1And R 2Be selected from the compound of H, methyl and ethyl, especially R 1And R 2All be those compounds of methyl.
R 3Be H or C 1-4Alkyl.The most common ground, it is H.
General formula (II) compound can be two kinds of steric isomers (IIa) or (IIb) form of one of them or the mixture of the two arbitrary proportion, and wherein (IIa) is cis epimer (syn epimer) and (IIb) be trans epimer (anti epimer):
Figure S200680051127XD00041
Can there be two kinds of stereoisomeric forms in any ratio in cis epimer (IIa): cis (+) form and cis (-) form.The present invention includes the mixture that uses two kinds of forms and two kinds of form arbitrary proportions respectively.Can there be two kinds of stereoisomeric forms in any ratio in trans epimer (IIa): trans (+) form and trans (-) form.The present invention includes the mixture that uses two kinds of forms and two kinds of form arbitrary proportions respectively.
Can there be two kinds of stereoisomer forms in general formula (III) compound: (+) form and (-) form.The present invention includes the mixture that uses two kinds of forms and two kinds of form arbitrary proportions respectively.
General formula (I) compound can be two kinds of steric isomers (Ia) or (Ib) form of one of them or the mixture of the two arbitrary proportion, and wherein (Ia) is cis epimer and (Ib) be trans epimer:
Can there be two kinds of stereoisomeric forms in any ratio in cis epimer (Ia): cis (+) form and cis (-) form.The present invention includes the mixture that uses two kinds of forms and two kinds of form arbitrary proportions respectively.Can there be two kinds of stereoisomeric forms in any ratio in trans epimer (Ia): trans (+) form and trans (-) form.The present invention includes the mixture that uses two kinds of forms and two kinds of form arbitrary proportions respectively.
Can use arbitrarily effective reductive agent to carry out the reductive cleavage of formula (II) compound phenmethyl part.Hydrogen under special metal hydrogenation catalyst effectively exists, said catalyzer for example are rhodium catalyst or preferred palladium catalyst, for example palladium carbon.
The consumption of reductive agent normally formula (II) compound 1 to 5, generally be 1 to 1.3 molar equivalent.When reductive agent is hydrogen, catalyst consumption normally formula (II) compound 0.001 to 0.5, generally be 0.01 to 0.1 molar equivalent.Metal catalytic hydrogenation can produce cis and trans epimer (IIa) and mixture (IIb) usually.
Reduction is carried out in inert solvent easily, and for example alcohol is such as methyl alcohol, ethanol, n-propyl alcohol or 2-propyl alcohol, and perhaps protonic solvent is such as the mixture of THF, t-butyl methyl ether, dioxane, ETHYLE ACETATE or glycol dimethyl ether or these solvents.Usually, said solvent is THF or methyl alcohol.
Carry out the reductive temperature and do not have strict restriction.Aptly, it carries out under 0 ℃ to 80 ℃, usually at 0 ℃ under 25 ℃, and easily at ambient temperature.Similarly, pressure does not have strict restriction yet, and reduction can be carried out under the pressure that raises or reduce, but is under environmental stress, to carry out easily.
The completion needed time of reduction is depended on the condition and the scale of reaction especially, but needs 1 to 48 hour usually, is generally 1 to 6 hour.
Also can use arbitrarily effective reductive agent to carry out the reductive cleavage of formula (III) compound phenmethyl part.Type, catalyzer, solvent and the reaction conditions of the reductive agent described in the reduction of formula (II) compound is effective for the reduction of formula (III) compound equally; Except the consumption of reductive agent is generally 3 to 6 of formula (III) compound; Be generally 3 to 3.3 molar equivalents, this be because outside cracking phenmethyl part also extra reason of having reduced two pairs of keys.Catalyst consumption, reductive temperature and pressure and to reduce the required time also be very identical with the reduction of formula (II) compound.
General formula (II) compound can be through forming the method preparation of another aspect of the present invention.This method comprises general formula (IV) compound:
Figure S200680051127XD00051
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure S200680051127XD00061
R wherein 3Have above given implication with Ph,
In the presence of at least a palladium complex of alkali and catalytic amount, react.
The suitable alkali that is used to carry out aforesaid method comprises alkoxide for example sodium tert-butoxide and potassium and methyl alcohol and sodium ethylate, and mineral alkali carbonate for example, such as salt of wormwood, sodium and caesium; Oxyhydroxide; Such as sodium hydroxide and Pottasium Hydroxide, and phosphoric acid salt, such as potassiumphosphate.Especially effectively alkoxide, especially sodium tert-butoxide.
When using sodium hydroxide or potassium, can add for example CETRIMIDE POWDER of phase-transfer catalyst as alkali.
The consumption of alkali is generally 1 to 3 molar equivalent of compound (IV), for example 1 to 2 molar equivalent.
Employed palladium complex is formed by palladium precursor and at least a suitable part usually in the method.When in being reflected at solvent, carrying out, said title complex is dissolved in the solvent usually.In the context of this method, palladium complex comprises those that be made up of ring-type organic palladium compound (" palladium ring ") and secondary phosphorus part significantly.
Said palladium complex can use a kind of preformed kind of brute force, perhaps can be that original position forms.Usually, it is to react through palladium precursor and at least a suitable part to prepare.Under the situation of not exclusively conversion, undissolved situation can appear in the palladium precursor of residual content or part in reaction mixture.
Effectively the palladium precursor can be selected from palladium, Palladous chloride, palladium chloride solution, palladium 2-(diphenylmethylene acetone) 3Or palladium-(diphenylmethylene acetone) 2, palladium-four (triphenylphosphine), palladium/carbon, palladium two chloro-two (cyanobenzene), palladium-(three-tertiary butyl phosphine) 2Perhaps palladium 2-(diphenylmethylene acetone) 3And palladium-(three-tertiary butyl phosphine) 2Mixture.
Effectively part for example is a tertiary phosphine-ligand, N-heterocyclic carbene ligand and phospho acid part.Normally two types of tertiary phosphine-ligand: unidentate ligand and bidentate ligand.Unidentate ligand can capture a palladium hapto, and bidentate ligand can capture two haptos, thus its can with palladium element chelating.
Below be tertiary phosphine, N-heterocycle carbine and phospho acid part and example with palladium ring of secondary phosphine part.
(A) monodentate phosphine ligand:
Three-tertiary butyl phosphine, Tetrafluoroboric acid tri-butyl phosphine (" P (tBu) 3HBF 4"), three-o-tolyl phosphine (" P (oTol) 3"), three-cyclohexyl phosphine (" P (Cy) 3"), 2-two-tertiary butyl-phosphino--1,1 '-biphenyl (" P (tBu) 2BiPh "), 2-two-cyclohexyl-phosphino--1,1 '-biphenyl (" P (Cy) 2BiPh "), 2-dicyclohexyl phosphino--2 ', 4 ', 6 '-three-sec.-propyl-1, (" P (tBu) (Adam) for 1 '-biphenyl (" x-Phos ") and the tertiary butyl-two-1-adamantyl-phosphine 2").
More information about monodentate phosphine ligand can obtain from US-2004-0171833.
(B) bidentate tertiary phosphine-ligand:
(B1) diphosphine ligand:
(B1.1) ferrocenyl-diphosphine ligand (" Josiphos " part):
1; 1 '-two (diphenylphosphine) ferrocene (dppf), 1; 1 '-two (two-tertiary butyl phosphine)-ferrocene, (R)-(-)-1-[(S)-2-(two (4-trifluoromethyl) phosphine) ferrocenyl] ethyl-two-tertiary butyl phosphine, (R)-(-)-1-[(S)-2-(two (3; 5-is two-trifluoromethyl) and phosphine) ferrocenyl] ethyl-dicyclohexylphosphontetrafluoroborate, (R)-(-)-1-[(S)-2-(two (3; 5-pair-trifluoromethyl) phosphine) ferrocenyl] ethyl two (3; The 5-3,5-dimethylphenyl) phosphine, (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocenyl] ethyl two-tertiary butyl phosphine, (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocenyl] ethyl dicyclohexylphosphontetrafluoroborate, (S)-(+)-1-[(R)-2-(dicyclohexylphosphontetrafluoroborate) ferrocenyl] ethyl dicyclohexylphosphontetrafluoroborate, (S)-(+)-1-[(R)-2-(dicyclohexylphosphontetrafluoroborate) ferrocenyl] ethyl diphenylphosphine, (R)-(-)-1-[(S)-2-(two (3; 5-dimethyl--4-p-methoxy-phenyl) ferrocenyl phosphine)] ethyl dicyclohexylphosphontetrafluoroborate, (S)-(+)-1-[(R)-and 2-(two-furyl phosphine) ferrocenyl] ethyl two-3; 5-xylyl phosphine, (R)-(-)-1-[(S)-2-(diphenylphosphine) ferrocenyl] ethyl two-tertiary butyl phosphine, (S)-(+)-1-[(R)-2-(diphenylphosphine) ferrocenyl] ethyl two-tertiary butyl phosphine, (R)-(-)-1-[(S)-2-(diphenylphosphine) ferrocenyl] ethyl dicyclohexylphosphontetrafluoroborate, (R)-(+)-1-[(R)-2-(diphenylphosphine) ferrocenyl] ethyl dicyclohexylphosphontetrafluoroborate, (S)-(+)-1-[(R)-2-(diphenylphosphine) ferrocenyl] ethyl dicyclohexylphosphontetrafluoroborate, (R)-(-)-1-[(S)-2-(dicyclohexyl base phosphine) ferrocenyl] ethyl diphenylphosphine, (R)-(-)-1-[(S)-2-(diphenylphosphine) ferrocenyl] ethyl two (3, the 5-3,5-dimethylphenyl) phosphine, (R)-(-)-1-[(S)-and 2-(two-tertiary butyl-phosphine) ferrocenyl] ethyl-two-o-tolyl phosphine
(R)-(-)-1-[(S)-2-(two (3,5-dimethyl--4-p-methoxy-phenyl) phosphine) ferrocenyl]-ethyl-two-tertiary butyl phosphine
Figure S200680051127XD00082
(R)-(-)-1-[(S)-2-(diethylammonium phosphine) ferrocenyl]-ethyl-two-tertiary butyl phosphine
(R)-(-)-1-[(S)-and 2-(P-methyl-P-isobutyl--phosphine) ferrocenyl] the ethyl dicyclohexylphosphontetrafluoroborate
Figure S200680051127XD00084
(R)-(-)-1-[(S)-and 2-(P-methyl-P-phenyl-phosphine) ferrocenyl] ethyl-di-t-butyl phosphine
Figure S200680051127XD00091
And the racemic mixture of their racemic mixture, especially 1-[2-(two-tertiary butyl phosphine) ferrocene] ethyl-two-o-tolyl phosphine, 1-[2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine and 1-[2-(diphenylphosphine) ferrocene] ethyl dicyclohexylphosphontetrafluoroborate.
(B1.2) dinaphthalene-diphosphine ligand:
2,2 '-two (diphenylphosphine)-1,1 '-dinaphthalene (" BINAP "), R-(+)-2; 2 '-two (two-p-methylphenyl phosphines)-1; 1 '-dinaphthalene (" Tol-BINAP "), racemize 2,2 '-two (two-p-methylphenyl phosphine)-1,1 '-dinaphthalene (" racemize Tol-BINAP ").
(B1.3) 9,9-dimethyl--4, two (phenylbenzene-phosphine)-xanthenes (" Xantphos ") of 5-.
(B2) amino phosphine 2 parts:
(B2.1) biphenyl ligand:
2-dicyclopentyl group phosphine-(N, N-dimethylamino)-1,1 '-biphenyl (" PCy 2NMe 2BiPh "), 2-di-t-butyl phosphine-(N, N-dimethylamino)-1,1 '-biphenyl (" P (tBu) 2NMe 2BiPh ").
(C) N-heterocyclic carbene ligand:
1,3-pair-(2, the 6-diisopropyl phenyl)-imidazolitm chloride (" I-Pr "), 1, two (1-the adamantyl)-imidazolitm chlorides (" I-Ad ") and 1 of 2-, 3-pair-(2, the 6-aminomethyl phenyl)-imidazolitm chloride (" I-Me ").
(D) phospho acid part:
Two-tertiary butyl-phosphine oxide.
(E) contain the palladium ring of secondary phosphine part:
The title complex of formula (A-1)
Figure S200680051127XD00092
Wherein " norb " is norcamphyl, and the title complex of formula (A-2)
Figure S200680051127XD00101
Palladium complex (A-1) is described in Synlett., and among the 2549-2552 (2004), its code name is " SK-CC01-A ".Title complex (A-2) is described among the Synlett. (ibid), and its code name is " SK-CC02-A ".
Other example that contains the palladium complex of phospho acid part is described in J.Org.Chem.66, and among the 8677-8681, their code name is " POPd ", " POPd2 " and " POPD1 ".Other example that contains the palladium complex of N-heterocyclic carbene ligand is a naphthoquinones-1, two (2, the 6-diisopropyl phenyl) imidazoles of 3--2-subunit-palladium (" [Pd-NQ-IPr] 2"), divinyl-tetramethyl-silica alkane-1, two (2, the 6-diisopropyl phenyl) imidazoles-2-subunit-palladium (" Pd-VTS-IPr "), 1 of 3-; two (2; the 6-diisopropyl phenyl) imidazoles-2-subunit-palladium chloride (" Pd-Cl-IPr "), 1 of 3-, two (2, the 6-diisopropyl phenyl) imidazoles-2-subunit-Palladium Diacetate (" Pd-OAc-IPr ") of 3-, allyl group-1; two (2, the 6-diisopropyl phenyl) imidazoles-2-subunit-Palladous chloride (" Pd-Al-Cl-IPr ") of 3-and formula (A-3) compound:
R wherein 5Be 2,6-diisopropyl phenyl or 2,4,6-trimethylphenyl.Can be at Organic Letters, 4,2229-2231 (2002) and Synlett., 275-278 finds more about [Pd-NQ-IPr] in (2005) 2, Pd-VTS-IPr, Pd-Cl-IPr, Pd-OAc-IPr and Pd-Al-Cl-IPr information.At Organic Letters, 5, can find more information among the 1479-1482 (2003) about formula (A-3) compound.
In said method, can use the mixture of single palladium complex or different palladium complexes to prepare general formula (II) compound.
The especially effectively precursor that is used to form palladium complex is to be selected from palladium, palladium 2-(diphenylmethylene acetone) 3, palladium-(diphenylmethylene acetone) 2, palladium chloride solution or palladium 2-(diphenylmethylene acetone) 3And palladium-(three-tertiary butyl phosphine) 2Those of mixture.Palladium is effective especially, also has Palladous chloride.
Form palladium complex and will use a kind of part at least.Usually palladium complex has the monodentate of being selected from tertiary phosphine-ligand, and at least a part in bidentate tertiary phosphine-ligand and the N-heterocyclic carbene ligand usually has the ferrocene-diphosphine ligands of being selected from, at least a part in biphenyl-biphosphine ligand and the amino phosphine part.
Suitable especially is to contain at least a palladium complex that is selected from following part, and said part is selected from three-tertiary butyl phosphine, P (tBu) 3HBF 4, P (oTol) 3, P (Cy) 3, P (tBu) 2BiPh, P (Cy) 2BiPh, x-Phos, P (tBu) are (Adam) 2, (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine, racemize 1-[2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine, (R)-(-)-1-[(S)-2-(two-tertiary butyl-phosphine) ferrocene] ethyl two-o-tolyl phosphine, racemize 1-[2-(two-tertiary butyl-phosphine) ferrocene] ethyl two-o-tolyl phosphine; Dppf; 1,1 '-bis (two-tertiary butyl phosphine)-ferrocene, (R)-(-)-1-[(S)-2-(diphenylphosphine) ferrocene] ethyl dicyclohexylphosphontetrafluoroborate, racemize 1-[2-(diphenylphosphine) ferrocene] ethyl dicyclohexylphosphontetrafluoroborate, (R)-(-)-1-[(S)-2-(diphenylphosphine) ferrocene] ethyl two-tertiary butyl phosphine, BINAP, Tol-BINAP, racemize Tol-BINAP, Xantphos, PCy 2NMe 2BiPh, P (tBu) 2NMe 2The palladium complex of BiPh, I-Pr, I-Ad and I-Me and formula (A-3), wherein R 5Be 2,6-diisopropyl phenyl or 2,4,6-trimethylphenyl.
Preferably have at least a palladium complex that is selected from following part, said part is selected from three-tertiary butyl phosphine, P (tBu) 3HBF 4, P (tBu) 2BiPh, P (Cy) 2BiPh, x-Phos, (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine, racemize 1-[2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine, (R)-(-)-1-[(S)-2-(two-tertiary butyl-phosphine) ferrocene] ethyl two-o-tolyl phosphine, racemize 1-[2-(two-tertiary butyl-phosphine) ferrocene] ethyl two-o-tolyl phosphine, dppf, PCy 2NMe 2BiPh and I-Pr.
Interested especially is to contain at least a palladium complex that is selected from following group part:
(i) three-tertiary butyl phosphine, P (tBu) 3HBF 4, P (tBu) 2BiPh, P (Cy) 2BiPh, x-Phos, PCy 2NMe 2BiPh and I-Pr;
(ii) three-tertiary butyl phosphine, P (tBu) 3HBF 4, PCy 2NMe 2BiPh and I-Pr;
(iii) three-tertiary butyl phosphine and P (tBu) 3HBF 4And
(iv) (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine and racemize 1-[2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine.
Most preferably contain PCy 2NMe 2BiPh, I-Pr, (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine or racemize 1-[2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine be as the palladium complex of part.
Special preferred complexes is that precursor is that Palladous chloride and part are the title complexs of (R)-(-)-1-[(S)-2-(dicyclohexylphosphontetrafluoroborate) ferrocene] ethyl two-tertiary butyl phosphine.
Palladium complex is to be used in the preparation of formula (II) compound with catalytic amount, and the mol ratio of itself and formula (IV) compound is 1: 10 to 1: 10000 usually, and general ratio is 1: 100 to 1: 1000, for example, and 1: 500 to 1: 700 or about 1: 600.Title complex can be pre-formed or original position forms through precursor and part are mixed, and said precursor and part are usually with equimolar amount or the use of equimolar substantially amount.
The formula V compound that is used for reacting with formula (IV) compound is benzene methanamine itself, wherein R easily 3Be H.
Easily, compound (IV) and (V) use with equimolar amount, perhaps compound (V) is excessive.For example, the consumption of formula V compound is suitably 1 to 3 molar equivalent of formula (IV) compound, is generally 1 to 2 molar equivalent, for example, and about 1.5 molar equivalents.
The preparation of formula (II) compound is carried out in inert organic solvents easily, and it is exsiccant preferably.The suitable solvent comprises 1 dme, two (terepthaloyl moietie) dme (diglyme), t-butyl methyl ether, pentane, hexane, hexanaphthene, THF, dioxane, toluene or YLENE, and their mixture.Preferred solvent is the diethylene glycol dialkyl ether with following general formula:
ROCH 2CH 2OCH 2CH 2OR
Wherein R is C 1-4Alkyl.The solvent of most convenient is 1 dme or diglyme.
But this method also can be carried out under the situation of solvent not having.Under these circumstances, the formula V compound uses with the amount excessive with respect to formula (IV) compound usually.
No matter whether use solvent, said method can be carried out under the temperature of environment or rising, preferably at 50 ℃ to 200 ℃ and be generally in 80 ℃ to 150 ℃ the scope and carry out.It can also carry out under the pressure of environment, rising or reduction, under environmental stress, carries out easily.
The time of reacting required depends on the scale that reaction is carried out, employed reagent and reaction conditions especially.But it needs 1 to 48 hour usually, be generally 4 to 30 hours, for example, 4 to 18 hours.
It possibly be useful under inert atmosphere, carrying out said method, and for example under nitrogen or argon gas atmosphere, most convenient ground is nitrogen.
For the preparation method who carries out preparation formula (II) compound, skilled chemist can prepare the out of Memory that obtains in the pertinent literature of aniline about general condition through carrying out palladium catalysis cross-coupling reaction with alkylamine by halogeno-benzene.Summary about this coupling appears at, for example, and Handbook of Organopalladium Chemistry for OrganicSynthesis; Vol.1,1051-1096 (2002), the Journal ofOrganometallic Chemistry; 576; 125-146 (1999) and Journal ofOrganometallic Chemistry, 653, among the 69-82 (2002).
General formula (III) compound can be through forming the method preparation of another aspect of the present invention.This method comprises general formula (VI) compound:
Figure S200680051127XD00131
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure S200680051127XD00132
R wherein 3Have above given implication with Ph,
In the presence of at least a palladium complex of alkali and catalytic amount, react.
The condition of alkali, palladium complex, compound (V) and said method is identical with the above-mentioned content that is used for preparing described in the method for compound (II) from 5-chloro-or 5-bromo-benzo norbornylene (IV).But under these circumstances, preferred especially palladium complex is that precursor is that Palladous chloride and part are the title complexs of carbenes I-Pr.In addition, all details described in the method for compound (II) can be used for the method for compound (III) equally.
Work as R 1And R 2Not not simultaneously, general formula (III) and (IV) compound can exist with the form of E-or Z-isomer, perhaps the form with the two arbitrary proportion mixture exists.
Formula (III) compound can be used for preparation formula (II) compound, and it also is effective in preparation formula (I) compound.
Therefore, in another aspect of the present invention, the preparation method of a kind of general formula (II) compound is provided:
Figure S200680051127XD00141
R wherein 1, R 2, R 3Have above given implication with Ph, said method comprises with reductive agent handles general formula (III) compound:
Figure S200680051127XD00142
R wherein 1, R 2, R 3Have above given implication with Ph, said reductive agent can be effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, but have kept PhCH (R 3) NH-part complete.
The reductive agent that this method is suitable is the hydrogen under metal hydrogenation catalyst exists, and said catalyzer for example is a rhodium catalyst, such as, rhodium carbon.
The consumption of reductive agent is generally 2 to 6 molar equivalents of compound (III), is generally 2 to 2.3 molar equivalents.
Catalyst consumption is generally 0.001 to 0.5 molar equivalent of compound (III), is generally 0.01 to 0.1.
Reduction is carried out in inert solvent easily, and for example, alcohol is such as methyl alcohol, ethanol, n-propyl alcohol or 2-propyl alcohol, perhaps the protonic solvent mixture of THF, t-butyl methyl ether, dioxane, ETHYLE ACETATE or glycol dimethyl ether or these solvents for example.Usually, said solvent is THF or methyl alcohol.
Carry out the reductive temperature and do not have strict restriction.Aptly, it carries out under 0 ℃ to 80 ℃, usually at 0 ℃ under 25 ℃, and easily at ambient temperature.Similarly, pressure does not have strict restriction yet, and reduction can be carried out under the pressure that raises or reduce, but is under the pressure of environmental stress to 4 crust, to carry out easily.
The completion needed time of reduction is depended on the condition and the scale of reaction especially, but needs 1 to 48 hour usually, is generally 1 to 6 hour.
The 5-chloro-of general formula (IV) or 5-bromo-benzo norbornylene can be through following method preparations, and said method comprises with reductive agent handles general formula (VI) compound:
Figure S200680051127XD00151
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and said reductive agent can be effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound.
The reductive agent that this method is suitable is the hydrogen under metal hydrogenation catalyst exists, and said catalyzer for example is to draw Buddhist nun's nickel, platinum carbon, platinum oxide (IV), palladium carbon, rhodium carbon, rhodium oxide (III) or rhodium-aluminium oxide catalyst.It is desirable to rhodium carbon, palladium carbon or platinum carbon.In an embodiment of the invention, use is rhodium carbon or palladium carbon.
The consumption of reductive agent is generally 2 to 6 molar equivalents of compound (VI), is generally 2 to 2.3 molar equivalents.
Catalyst consumption is generally 0.01 to 50mol% of compound (VI), is generally 0.1 to 20mol%.
Reduction is carried out in inert solvent easily; For example; Alcohol is such as methyl alcohol, ethanol, n-propyl alcohol or 2-propyl alcohol, the perhaps solvent of THF, ETHYLE ACETATE, toluene, t-butyl methyl ether, dioxane, glycol dimethyl ether or methylene dichloride for example, the mixture of perhaps such solvent.Usually, said solvent is THF, ethanol or methyl alcohol, preferred THF or methyl alcohol.
Carry out the reductive temperature and do not have strict restriction.Aptly, it carries out under 0 ℃ to 100 ℃, usually 0 ℃ under 25 ℃, and under 20 ℃ to 25 ℃, carry out easily.
Similarly, pressure does not have strict restriction yet, and reduction can be generally 1 to 50 crust at 1 to 150 crust, is generally 1 to 25 crust, for example, carries out under the pressure of 1 to 10 crust.
Formula (IV) compound can obtain with the form of cis or trans epimer or the two mixture.Usually, it is to obtain with the form of the mixture of two kinds of epimers, and the ratio between them depends on selected concrete hydrogenation catalyst especially.
The 5-chloro-of general formula (VI) or 5-bromobenzene and norbornadiene can be through following method preparations, and said method comprises the halo benzyne with formula (VII):
Figure S200680051127XD00161
Wherein X is a chlorine or bromine,
Fulvene with general formula (VIII):
Figure S200680051127XD00162
R wherein 1And R 2Have above given implication,
In inert organic solvents, react.
According to the mode that produces halo benzyne (VII); Said method is at for example THF, 1; 4-dioxane, glycol dimethyl ether, diethyl ether, t-butyl methyl ether, methyl ethyl ketone, ETHYLE ACETATE, methyl acetate or aromatic series or aliphatic hydrocarbon, for example, in the organic solvent of toluene, YLENE, benzene, hexane, pentane or sherwood oil; And under-20 ℃ to+10 ℃ temperature, carry out, said temperature can be lifted to envrionment temperature or higher temperature is reacted to accomplish.
The 5-chloro-of formula (VI) or 5-bromobenzene and norbornadiene can be through cancellation reaction mixtures in saturated ammonium chloride solution for example in water medium; At solvent extraction product in the ETHYLE ACETATE for example; With for example salt solution and water washing solvent extractable matter; Be dried and steam to desolventize to obtain halo benzo norbornadiene (VI) and obtain separating, said halo benzo norbornadiene can be through from for example crystallization and being further purified the hexane of solvent.
Halo benzyne (VII) can obtain through following method, said method comprise with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With organo-metallic material C for example 1-6Alkyl-or phenyl lithium or C 1-6Alkyl-or phenyl-magnesium-halide under inert atmosphere, react.
Preferably, X is a chlorine.
C 1-6Alkyl-or phenyl-magnesium-halide be preferably muriate or bromide and sec.-propyl chlorination more preferably or magnesium bromide.
If use C 1-6Alkyl-or phenyl lithium is reflected under the existence of fulvene (VIII) and carries out, thereby directly obtains 5-chloro-or 5-bromobenzene and norbornadiene.Under these circumstances, reaction is in the solvent of for example toluene, benzene, hexane, pentane or sherwood oil, under-20 ℃ to 0 ℃ temperature, generally under-10 ℃ to 0 ℃ temperature, carries out.Reaction mixture can carry out being heated to envrionment temperature before the cancellation in through aforesaid water medium.
If use C 1-6Alkyl-or phenyl-magnesium-halide; 5-chloro-or 5-bromobenzene and norbornadiene can form in the program of substep; Said halo benzyne (VII) forms in the first step, and 5-chloro-or 5-bromobenzene and norbornadiene perhaps formed through then joining in the fulvene (VIII) through then adding fulvene (VIII) in second step.Halogeno-benzene (IX) or (X) and C 1-6Alkyl-or phenyl-magnesium-halide between the first step reaction be under-78 ℃ to 0 ℃ temperature, to carry out, generally under-20 ℃ to-10 ℃, carry out.Under first kind of situation, then under-20 ℃ to+10 ℃, carry out the adding of fulvene, generally under-10 ℃ to 0 ℃, carry out.Through with mixture heating up to envrionment temperature or preferably be heated to the reflux temperature of the solvent that uses, promote to react.Under second kind of situation, then the adding in fulvene is under 20 ℃ to 100 ℃ temperature, to carry out, generally at 70 ℃ under 95 ℃.Reaction continues to stir one hour to accomplish conversion.
The suitable solvent comprises THF, 1, and 4-dioxane, glycol dimethyl ether, diethyl ether, t-butyl methyl ether, hexane, sherwood oil, pentane, benzene, toluene and YLENE are preferably toluene, THF or hexane.Can separate 5-chloro-or 5-bromobenzene and norbornadiene through in aforesaid water medium, carrying out cancellation then.
The inert atmosphere that reacts therein is, for example, and nitrogen atmosphere.
This conversion is described in Organic Letters by J.Coe, in 6,1589 (2004) or be described in Angew.Chem.116 by P.Knochel, in 4464 (2004).
Formula (IX) or (X) 1,2, the 3-trihalogenated benzene is known and/or can be through currently known methods preparation.For example, 1-bromo-2,3-two chloro-benzene can be through so-called Sandmeyer reaction by 2, the preparation of 3-two chloro-aniline.Such Sandmeyer reaction can be through using organic sub-nitrate; For example nitrite tert-butyl or Isopentyl nitrite are at organic solvent for example in the acetonitrile, in the presence of as the cupric bromide of bromizating agent and carry out (like Journal of OrganicChemistry; 1977; 42, described in the 2426-31), perhaps carry out through two-step reaction; Said two-step reaction is included in the acidic aqueous reaction medium diazotization of under 0 ℃ to 15 ℃ temperature, using inorganic nitrite and then reaction mixture is joined in the cupric bromide solution (like Recueil des Travaux Chimiques des Pays-Bas et de la Belgique; 1932,51, described in 98-113 and the JP-6-2114-921).
The 6-alkyl-or 6,6-dialkyl group fulvene can be according to people such as M.Neuenschwander, Helv.Chim.Acta, and 54,1037 (1971), ibid 48,955 (1965); People such as R.D.Little, J.Org.Chem.49,1849 (1984); People such as I.Erden, J.Org.Chem.60,813 (1995) and people such as S.Collins, J.Org.Chem.55, the description in 3395 (1990) and preparing.
The fulvene of general formula (VIII):
Figure S200680051127XD00181
R wherein 1And R 2Have above given implication, can be through encircling penta-1,3-diene and compound (VIIIa):
Figure S200680051127XD00191
R wherein 1And R 2Have above given implication,
In the presence of alkali, react and prepare.As alkali, preferably use tetramethyleneimine, morpholine or thiomorpholine, more preferably tetramethyleneimine.In such reaction, can use 0.01 to 1 normal alkali.Preferably, use 0.25 to 0.8 normal alkali.
6, the preparation of 6-dimethyl-fulvene:
With 950g (30mol) methyl alcohol, 543g (7.8mol) acetone and 397g (6mol) cyclopentadiene mix, and are cooled to-5 ℃.Careful 107g (1.5mol) tetramethyleneimine that adds.Reaction mixture was stirred 2 hours down at-5 ℃.Through adding acetate and water termination reaction.After being separated, use the salt solution extracted organic phase, evaporating solvent.Obtain 535g 6,6-dimethyl-fulvene (purity: 93%; Productive rate: theoretical value 78%).
For ease, above-mentioned reaction is summarised in the following scheme 2.
Scheme 2
Figure S200680051127XD00201
Like above discussion, invention comprises following independent aspect:
(1) by (II) or (III) form (I),
(2) form (II) by (IV),
(3) form (III) by (VI),
(4) form (II) by (III),
(5) form (IV) by (VI),
(6) by (VII) form (VI) and
(7) by (IX) or (X) form (VII).
The present invention further comprises the method that following multistep is rapid, and said method comprises:
(8) form (I) by (IV) through (II),
(9) form (I) by (VI) through (III),
(10) form (I) by (VI) through (IV) with (II),
(11) form (I) by (VI) through (III) with (II),
(12) form (VI) by (IX) or (X) through (VII),
(13) form (I) by (IX) or (X) through (VI) with (III),
(14) by (IX) or (X) through (VI), (IV) and (II) form (I) and
(15) by (IX) or (X) through (VI), (III) and (II) form (I).
Therefore, according to a further aspect of the invention, the preparation method of a kind of general formula (I) compound is provided:
Figure S200680051127XD00211
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with general formula (IV) compound:
Figure S200680051127XD00212
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure S200680051127XD00213
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
Figure S200680051127XD00221
R wherein 1, R 2, R 3Has above given implication with Ph; With
(b) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays next amino.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
Figure S200680051127XD00222
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with general formula (VI) compound:
Figure S200680051127XD00223
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure S200680051127XD00224
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl, in the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure S200680051127XD00231
R wherein 1, R 2, R 3Has above given implication with Ph; With
(b) handle formed general formula (III) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, and effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
Figure S200680051127XD00232
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) handle general formula (VI) compound with reductive agent:
Figure S200680051127XD00233
R wherein 1And R 2Having above given implication and X is chlorine or bromine,
Said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, thereby form general formula (IV) compound:
Figure S200680051127XD00241
R wherein 1And R 2Has above given implication with X;
(b) with the benzene methanamine of formed general formula (IV) compound and logical formula V:
Figure S200680051127XD00242
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
Figure S200680051127XD00243
R wherein 1, R 2, R 3Has above given implication with Ph; With
(c) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays next amino.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
Figure S200680051127XD00244
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with general formula (VI) compound:
Figure S200680051127XD00251
R wherein 1And R 2Having above given implication and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure S200680051127XD00252
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure S200680051127XD00253
R wherein 1, R 2, R 3Has above given implication with Ph;
(b) handle formed general formula (III) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, but have kept PhCH (R 3) NH-part complete, thereby form general formula (II) compound:
Figure S200680051127XD00254
R wherein 1, R 2, R 3Has above given implication with Ph; With
(c) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays next amino.
The preparation method of a kind of general formula (VI) compound is provided in another aspect of the present invention:
Figure S200680051127XD00261
R wherein 1And R 2Be H or C independently 1-6Alkyl and X are chlorine or bromines, said method comprise with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Figure S200680051127XD00262
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With organo-metallic material C for example 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide is in the presence of the fulvene of general formula (VIII):
Figure S200680051127XD00263
R wherein 1And R 2Have above given implication,
Under inert organic solvents and inert atmosphere, react.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Figure S200680051127XD00272
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With organo-metallic material C for example 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Figure S200680051127XD00273
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure S200680051127XD00274
R wherein 1And R 2Have above given implication, in inert organic solvents, react, thereby form general formula (VI) compound:
Figure S200680051127XD00275
R wherein 1And R 2Having above given implication and X is chlorine or bromine;
(c) with the benzene methanamine of formed general formula (VI) compound and logical formula V:
Figure S200680051127XD00281
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure S200680051127XD00282
R wherein 1, R 2, R 3Has above given implication with Ph; With
(d) handle formed general formula (III) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3Thereby) the last cracking of NH-stay next amino, and effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Figure S200680051127XD00284
Wherein X is that chlorine or bromine and Y are bromine or iodines, with organo-metallic material C for example 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure S200680051127XD00292
R wherein 1And R 2Have above given implication, in inert organic solvents, react, thus the compound of formation general formula (VI):
Figure S200680051127XD00293
R wherein 1And R 2Having above given implication and X is chlorine or bromine;
(c) handle formed general formula (VI) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, thereby form the compound of general formula (IV):
R wherein 1, R 2Has above given implication with X;
(d) with the benzene methanamine of formed general formula (IV) compound and logical formula V:
Figure S200680051127XD00295
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
Figure S200680051127XD00301
R wherein 1, R 2, R 3Has above given implication with Ph; With
(e) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays next amino.
The preparation method of a kind of general formula (I) compound is provided in another aspect of the present invention:
Figure S200680051127XD00302
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With organo-metallic material C for example 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Figure S200680051127XD00311
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure S200680051127XD00312
R wherein 1And R 2Have above given implication, in inert organic solvents, react, thus the compound of formation general formula (VI):
Figure S200680051127XD00313
R wherein 1And R 2Having above given implication and X is chlorine or bromine;
(c) with the benzene methanamine of formed general formula (VI) compound and logical formula V:
Figure S200680051127XD00314
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
R wherein 1, R 2, R 3Has above given implication with Ph;
(d) handle formed general formula (III) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, but have kept PhCH (R 3) NH-part complete, thereby form general formula (II) compound:
Figure S200680051127XD00321
R wherein 1, R 2, R 3Has above given implication with Ph; With
(e) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays next amino.
Can be like compound listed in the following table 1 through exemplary general formula (I) compound of the inventive method preparation.
In table 1, provided R together 1And R 2Value and characterization data.
Table 1
Compound N o. R 1 R 2 Fusing point (℃) & is suitable/reverse proportionality (by glc) 1H-NMR proton displacement δ (ppm) (CDCl 3)
1.01 H H
1.02 H CH 3
1.03 H C 2H 5
1.04 H n-C 3H 7
1.05 H i-C 3H 7
1.06 H n-C 4H 9
1.07 H t-C 4H 9
Compound N o. R 1 R 2 Fusing point (℃) & is suitable/reverse proportionality (by glc) 1H-NMR proton displacement δ (ppm) (CDCl 3)
1.08 H i-C 4H 9
1.09 H sec-C 4H 9
1.10 H n-C 5H 11
1.11 H n-C 6H 13
1.12 CH 3 CH 3 M.p.54-56; Suitable/reverse proportionality 98: 02 1H (cis component): 6.91 (t, 1H), 6.64 (d, 1H), 6.48 (d, 1H), 3.54 (brd is with D 2O exchanges, 2H), 3.20 (m, 1H), 3.15 (m, 1H), 1.91 (m, 2H), 1.53 (d, 1H), 1.18 (m, 2H), 1.02 (m, 1H), 0.81 (d, 6H). 13C (cis component): 147.73,140.03,130.15,126.41,113.35,112.68,69.00,46.62,42.06,27.74,26.83,25.45,22.32,22.04. 1H (trans component): 6.89 (t, 1H), 6.63 (d, 1H), 6.46 (d, 1H), 3.55 (brd is with D 2O exchanges, 2H), 3.16 (m, 1H), 3.13 (m, 1H), 1.87 (m, 2H), 1.48 (d, 1H), 1.42 (m, 1H), 1.12 (m, 2H), 0.90 (d, 6H). 13C (trans component): 150.72,138.74,133.63,126.15,112.94,111.53,68.05,45.21,40.61,26.25,24.47,23.55,20.91 (2x).
1.12 CH 3 CH 3 Viscous oil is suitable/reverse proportionality 75: 25
1.13 CH 3 C 2H 5
1.14 C 2H 5 C 2H 5
General formula (II), (III), (IV) and intermediate chemicals (VI) are new compounds, and they have formed others of the present invention.
Therefore, the present invention also provides the compound of general formula (II):
Figure S200680051127XD00331
R wherein 1And R 2Be H or C independently 1-6Alkyl, R 3Be H or C 1-4Alkyl, and Ph is a phenyl.Interested especially is R 1And R 2Be compound (II), the especially R that is selected from H, methyl and ethyl 1And R 2All be those of methyl.Preferred R 3Be H.
Exemplary formula (II) compound is like compound listed in the following table 2.In table 2, R 3Be H, Ph is phenyl and R 1And R 2Value provide with characterization data.
Table 2
Compound N o. R 1 R 2 Fusing point (℃) & is suitable/reverse proportionality (by glc) 1H-NMR proton displacement δ (ppm) (CDCl 3)
2.01 H H
2.02 H CH 3
2.03 H C 2H 5
2.04 H n-C 3H 7
2.05 H i-C 3H 7
2.06 H n-C 4H 9
2.07 H t-C 4H 9
2.08 H i-C 4H 9
2.09 H sec-C 4H 9
2.10 H n-C 5H 11
2.11 H n-C 6H 13
2.12 CH 3 CH 3 M.p.87-90; Suitable/reverse proportionality 91: 9 1H:7.39-7.28 (m, 5H, suitable+anti-), 6.97 (t, 1H, suitable+anti-), 6.63 (d, 1H, suitable+anti-), 6.48 (d, 1H, suitable+anti-), 4.38 (dd, 2H, suitable+anti-), 3.84 (brd is with D 2O exchanges, and 1H is suitable+anti-), 3.19-3.14 (m, 2H, suitable+anti-), 1.94-1.90 (m, 2H, suitable+anti-), 1.53 (dt, J d=10Hz, 1H, suitable), ca.1.43 (m, 1H, anti-), 1.20-1.16 (m, 2H, suitable+anti-), 1.06 (m, 1H, suitable), 0.92-0.90 (2d, 6H, anti-), 0.82 and 0.81 (2d, 6H, suitable).
2.13 CH 3 C 2H 5
2.14 C 2H 5 C 2H 5
The present invention further provides general formula (III) compound:
Figure S200680051127XD00351
R wherein 1And R 2Be H or C independently 1-6Alkyl, R 3Be H or C 1-4Alkyl, and Ph is a phenyl.Interested especially is R 1And R 2Be compound (III), the especially R that is selected from H, methyl and ethyl 1And R 2All be those of methyl.Preferred R 3Be H.Work as R 1And R 2Not simultaneously, compound (III) can not exist with the form of mixtures of E-or Z-enantiomer or the two arbitrary proportion.The present invention includes independent enantiomer and their any mixture.
Exemplary formula (III) compound is like compound listed in the following table 3.In table 3, R 3Be H, Ph is phenyl and R 1And R 2Value provide with characterization data.
Table 3
Compound N o. R 1 R 2 Fusing point (℃) 1H-NMR proton displacement δ (ppm) (CDCl 3)
3.01 H H
3.02* H CH 3
3.03* H C 2H 5
3.04* H n-C 3H 7
3.05* H i-C 3H 7
3.06* H n-C 4H 9
3.07* H t-C 4H 9
3.08* H i-C 4H 9
3.09* H sec-C 4H 9
3.10* H n-C 5H 11
3.11* H n-C 6H 13
3.12 CH 3 CH 3 m.p. 98-100 1(m, 5H), 6.93 (m, 2H), 6.86 (t, 1H), 6.77 (d, 1H), 6.38 (d, 1H), 4.39 (m, 1H), 4.36 (m, 1H), 4.38 (s, 2H), 3.8 (brd is with D for H:7.42-7.24 2O exchanges, 1H), 1.55 (s, 3H), 1.54 (s, 3＞H).
3.13* CH 3 C 2H 5
3.14 C 2H 5 C 2H 5
* represent the E/Z-mixture
The present invention further provides general formula (IV) compound:
Figure S200680051127XD00361
R wherein 1And R 2Be H or C independently 1-6Alkyl and X are chlorine or bromines.Interested especially is R 1And R 2Be compound (IV), the especially R that is selected from H, methyl and ethyl 1And R 2All be those of methyl.Preferred X is a chlorine.
Exemplary formula (IV) compound is like compound listed in the following table 4.In table 4, provided R together 1, R 2Value and characterization data with X.
Table 4
Chemical combination No. X R 1 R 2 Fusing point (℃) & is suitable/reverse proportionality (by glc) 1H-NMR proton displacement δ (ppm) (CDCl 3)
4.01 Br H H
4.02 Br H CH 3
4.03 Br H C 2H 5
4.04 Br H n-C 3H 7
4.05 Br H i-C 3H 7
4.06 Br H n-C 4H 9
4.07 Br H t-C 4H 9
4.08 Br H i-C 4H 9
4.09 Br H sec-C 4H 9
4.10 Br H n-C 5H 11
4.11 Br H n-C 6H 13
4.12 Br CH 3 CH 3
4.13 Br CH 3 C 2H 5
4.14 Br C 2H 5 C 2H 5
4.15 Cl H H
4.16 Cl H CH 3
Compound N o. X R 1 R 2 Fusing point (℃) & is suitable/reverse proportionality (by glc) 1H-NMR proton displacement δ (ppm) (CDCl 3)
4.17 Cl H C 2H 5
4.18 Cl H n-C 3H 7
4.19 Cl H i-C 3H 7
4.20 Cl H n-C 4H 9
4.21 Cl H t-C 4H 9
4.22 Cl H i-C 4H 9
4.23 Cl H sec-C 4H 9
4.24 Cl H n-C 5H 11
4.25 Cl H n-C 6H 13
4.26 Cl CH 3 CH 3 M.p.61-62; Suitable/reverse proportionality 91: 9 1H (cis component): 7.06 (d, 1H), 7.04 (d, 1H), 7.01 (t, 1H), 3.49 (m, 1H), 3.24 (m, 1H), 1.96-1.97 (m, 2H), 1.57 (dt, J d＝10Hz，J t＝1.2 Hz，1H)，1.16-1.22(m，2H)，0.93 (m，1H)，0.83(d，3H)，0.81(d， 3H)。 13C (cis component): 148.6,143.8,128.1,127.0,125.8,119.8,69.0,47.1,44.8,27.4,26.4,25.5,22.1,22.0. 1H (trans component): 7.03 (d, 1H), 7.00 (d, 1H), 6.97 (t, 1H), 3.43 (m, 1H); 3.21 (m, 1H), 1.97-1.92 (m, 2H), 1.51 (br.d, J=10.8Hz, 1H), 1.43 (m; 1H), 1.16-1.10 (m, 2H), 0.92 (d, 3H), 0.90 (d, 3H). 13C (trans component): 151.4,146.7,126.8,126.6,125.5,118.7,67.9,45.6,43.4,26.1,24.2,23.2,20.9,20.8.
4.27 Cl CH 3 C 2H 5
4.28 Cl C 2H 5 C 2H 5
The present invention further provides general formula (VI) compound:
Figure S200680051127XD00381
R wherein 1And R 2Be H or C independently 1-6Alkyl and X are chlorine or bromines.Interested especially is R 1And R 2Be compound (VI), the especially R that is selected from H, methyl and ethyl 1And R 2All be those of methyl.Preferred X is a chlorine.Work as R 1And R 2Not simultaneously, compound (VI) can not exist with the form of mixtures of E-or Z-isomer or the two arbitrary proportion.The present invention includes independent enantiomer and their any mixture.
Exemplary formula (VI) compound is like compound listed in the following table 5.In table 5, R 1, R 2Provide with characterization data with the value of X.
Table 5
Compound N o. X R 1 R 2 Fusing point (℃) 1H-NMR proton displacement δ (ppm) (CDCl 3)
5.01 Br H H
5.02* Br H CH 3
5.03* Br H C 2H 5
5.04* Br H n-C 3H 7
5.05* Br H i-C 3H 7
5.06* Br H n-C 4H 9
5.07* Br H t-C 4H 9
5.08* Br H i-C 4H 9
5.09* Br H sec-C 4H 9
5.10* Br H n-C 5H 11
5.11* Br H n-C 6H 13
5.12 Br CH 3 CH 3 90-91 1H：7.13(d，1H)，7.06(d，1H)，6.95(m， 2H)，6.81(t，1H)，4.57(m，1H)，4.45(m， 1H)，1.58(s，3H)，1.55(s，3H)。 13C：160.46，152.91，150.81，143.26， 142.24127.68，126.10，119.44，115.67， 103.73，51.69，51.16，19.04，18.90。
5.13* Br CH 3 C 2H 5
5.14 Br C 2H 5 C 2H 5
Compound N o. X R 1 R 2 Fusing point (℃) 1H-NMR proton displacement δ (ppm) (CDCl 3)
5.15 Cl H H
5.16* Cl H CH 3
5.17* Cl H C 2H 5
5.18* Cl H n-C 3H 7
5.19* Cl H i-C 3H 7
5.20* Cl H n-C 4H 9
5.21* Cl H t-C 4H 9
5.22* Cl H i-C 4H 9
5.23.* Cl H sec-C 4H 9
5.24* Cl H n-C 5H 11
5.25* Cl H n-C 6H 13
5.26 Cl CH 3 CH 3 83-85 1H：7.10(d，1H)，6.94(m，2H)，6.93 6.85(m，2H)，4.63(m，1H)，4.41(m，1H)， 1.57(s，3H)，1.55(s，3H). 13C：160.55，152.84，148.35，143.23， 142.21，126.90，125.77，124.90，118.92， 103.57，51.35，49.11，19.00，18.89。
5.27* Cl CH 3 C 2H 5
5.28 Cl C 2H 5 C 2H 5
* represent the E/Z-mixture
Following indefiniteness embodiment has set forth the present invention in further detail.
Embodiment 1
The preparation of 5-bromo-9-isopropylidene-benzo norbornadiene (compound N o.5.12)
Figure S200680051127XD00391
A) n-Butyl Lithium variant, from 1,3-two bromo-2-iodo-benzene
0 ℃ with nitrogen atmosphere under, within 10 minutes, to stir 1; 3-two bromo-2-iodo-benzene (5.00g, 13.8mmol) with 6,6-dimethyl-fulvene (7.57g; Chemical examination is 97%, n-Butyl Lithium (14.5mmol) toluene solution of Dropwise 5 .5ml 2.5M in dry toluene 69mmol) (60ml) solution.0 ℃ continue down through 10 minutes and at ambient temperature through 1 hour after, in the saturated aqueous solution with reaction mixture impouring ammonium chloride, use ethyl acetate extraction, with salt solution and water washing, through dried over sodium sulfate and evaporation.Roughage is made moving phase with hexane on silica gel, carry out purifying, thereby obtain 2.55g yellow oily expectation product (verify as 99% through g.l.c., productive rate is 70%).From cold hexane, obtain m.p.90-91 ℃ yellow crystals.
B) n-Butyl Lithium variant, from 1,2,3-three bromo-benzene
-5 to 0 ℃ with nitrogen atmosphere under, within 10 minutes, to stir 1; 2; 3-three bromo-benzene (4.34g, 13.8mmol) with 6,6-dimethyl-fulvene (2.38g; Chemical examination is 92.6%, n-Butyl Lithium (14.5mmol) toluene solution of Dropwise 5 .5ml 2.5M in dry toluene 20.7mmol) (60ml) solution.0 ℃ continue down through 10 minutes and at ambient temperature through 2 hours after, in the saturated aqueous solution with reaction mixture impouring ammonium chloride, use ethyl acetate extraction, with salt solution and water washing, through dried over sodium sulfate and evaporation.Roughage is made moving phase with hexane on silica gel, carry out purifying, thereby obtain 2.38g yellow oily expectation product (verify as 84% through g.l.c., productive rate is 55%).
C) isopropylmagnesium chloride variant, from 1,3-two bromo-2-iodo-benzene
Under nitrogen atmosphere, with 1, (45.95g, down (63.5ml, the 2M isopropylmagnesium chloride in 0.124mol) reacted 1 hour dry toluene 0.124mol) (200ml) solution 3-two bromo-2-iodo-benzene with THF at-8 to-15 ℃.Then add 6 down at 0 ℃, (16.54g, chemical examination is 97.8% to 6-dimethyl-fulvene, 0.15mmol), under reflux temperature, heats 19 hours then.In the saturated aqueous solution with reaction mixture impouring ammonium chloride, use ethyl acetate extraction, with salt solution and water washing, through dried over sodium sulfate and evaporation.Roughage is made moving phase with hexane separate in the enterprising circumstances in which people get things ready for a trip spectrum of silica gel, thus the yellow solid product that obtains expecting (27.84g verifies as 79% through g.l.c., and productive rate is 66%).
Embodiment 2
The preparation of 5-chloro-9-isopropylidene-benzo norbornadiene (compound N o.5.26)
Figure S200680051127XD00411
A) n-Butyl Lithium variant, from 1,3-two chloro-2-iodo-benzene
0 ℃ with nitrogen atmosphere under; Within 16 minutes, to 1 of stirring, 3-two chloro-2-iodo-benzene (38.21g; 140mmol) with 6; (46.35g verifies as 96.2% to 6-dimethyl-fulvene, n-Butyl Lithium (147mmol) toluene solution of Dropwise 5 8.8ml 2.5M in dry toluene 420mmol) (600ml) solution.0 ℃ continue down through 10 minutes after, with reaction mixture hold over night at ambient temperature.Carry out water treatment with saturated aqueous ammonium chloride and with ethyl acetate extraction after; With salt solution and water washing; Through dried over sodium sulfate, thereby obtain roughage, said roughage is made moving phase with hexane on silica gel, carry out purifying through chromatogram; Thereby obtain 19.79g yellow oily expectation product (verify as 94.7% through g.l.c., productive rate is 62%).From cold hexane, obtain m.p.83-85 ℃ yellow crystals.
B) isopropylmagnesium chloride variant, from 2-bromo-1,3-two chloro-benzene
Under nitrogen atmosphere, with 2-bromo-1, (22.59g, down (50ml, the 2M isopropylmagnesium chloride in 0.1mol) reacted 1 hour dry toluene 0.1mol) (100ml) solution the 3-dichlorobenzene with THF at-8 to-15 ℃.Then add 6 down at 0 ℃, (13.03g verifies as 97.8% to 6-dimethyl-fulvene, 0.12mol), under reflux temperature, heats 10 hours then.Carry out water treatment with saturated aqueous ammonium chloride and with ethyl acetate extraction after; With salt solution and water washing,, thereby obtain roughage through dried over sodium sulfate; Said roughage is made moving phase with hexane on silica gel, carry out purifying through chromatogram; Thereby obtain the expectation product (19.03g verifies as 95.2% through g.l.c., and productive rate is 83.6%) of yellow solid.
C) isopropylmagnesium chloride variant, from 1,3-two chloro-2-iodo-benzene
Under nitrogen atmosphere, with 1, (2.39g, down (4.4ml, the 2M isopropylmagnesium chloride in 8.76mmol) reacted 1 hour dry toluene 8.76mmol) (10ml) solution 3-two chloro-2-iodo-benzene with THF at-8 to-15 ℃.Then add 6 down at 0 ℃, (1.45g, chemical examination is 96.2% to 6-dimethyl-fulvene, 13.15mmol), under reflux temperature, heats 22 hours then.Carry out water treatment with saturated aqueous ammonium chloride and with ethyl acetate extraction after; With salt solution and water washing,, thereby obtain roughage through dried over sodium sulfate; Said roughage is made moving phase with hexane on silica gel, carry out purifying through chromatogram; Thereby obtain the expectation product (1.75g is 86.4% through the g.l.c. chemical examination, and productive rate is 79.5%) of yellow solid.
D) isopropylmagnesium chloride variant, from 1-bromo-2,3-two chloro-benzene
Under nitrogen atmosphere, with 1-bromo-2, (22.59g, down (50ml, the 2M isopropylmagnesium chloride in 0.1mol) reacted 1 hour dry toluene 0.1mol) (100ml) solution 3-two chloro-benzene with THF at-8 to-15 ℃.Then add 6 down at 0 ℃, (16.56g verifies as 96.2% to 6-dimethyl-fulvene, 0.15mol), under reflux temperature, heats 10 hours then.Carry out water treatment with saturated aqueous ammonium chloride and with ethyl acetate extraction after; With salt solution and water washing,, thereby obtain roughage through dried over sodium sulfate; Said roughage is made moving phase with hexane to be made moving phase with hexane and on silica gel, carries out purifying through chromatogram; Thereby obtain the expectation product (19.57g is 84.4% through the g.l.c. chemical examination, and productive rate is 76.2%) of yellow solid.
E) isopropylmagnesium chloride variant, from 1-bromo-2,3-two chloro-benzene
Under nitrogen atmosphere, with 1-bromo-2, (37.6g, THF 0.165mol) (170ml) solution join THF under-10 ℃ (100g in the 2M isopropylmagnesium chloride in 0.206mol), and stirs reaction mixture above 1 hour 3-two chloro-benzene.In 4 hours, this Ge Shi midbody is joined 6 under 85 ℃, (19.9g is 0.173mol) in the toluene solution for 6-dimethyl-fulvene.Reaction mixture is stirred above one hour to accomplish reaction conversion.With saturated aqueous ammonium chloride cancellation reaction and phase-splitting.Thereby the expectation compound N of evaporation THF/ toluene acquisition yellow solid is (39.2g, productive rate are 80.5%) o.5.26.
Embodiment 3
The preparation of 5-bromo-9-sec.-propyl-benzo norbornylene (suitable/the back mixing compound, syn-enriched) (compound N o.4.26)
Figure S200680051127XD00431
Under 20 to 25 ℃, 5-chloro-9-isopropylidene-benzo norbornadiene (30.0g, 0.1384mol prepare according to the description among the embodiment 2) is being carried out hydrogenation under the environmental stress in methyl alcohol (300ml) in the presence of 5%Rh/C (6g).Ratio of absorption of hydrogen was 97% after 2 hours.Filter and evaporate, make moving phase with hexane then and on silica gel, carry out purifying, thereby obtain the expectation product (29.05g, productive rate are 95%) of colorless solid, m.p.61-62 ℃.Measuring suitable/reverse proportionality through g.l.c. is 91: 9.
Embodiment 4
N-phenmethyl-5-amino-5-sec.-propyl-benzo norbornylene (suitable/the back mixing compound, syn-enriched; Compound N is o.2.12) preparation
Figure S200680051127XD00432
A) from 5-chloro-9-sec.-propyl-benzo norbornylene (syn-enriched 91: 9; Compound No.4.26)
Aa) use R (-)-two-tertiary butyl-[1-[(S)-2-(dicyclohexylphosphontetrafluoroborate)-ferrocenyl] Ethyl] phosphine is as part
i)(S/C?100，1mol％)
5-chloro-9-sec.-propyl-benzo norbornylene [syn-enriched 91: 9 under argon gas in the Schlenk pipe; O.4.26, compound N prepares according to the description among the embodiment 3] (1.0g, 4.53mmol); Sodium tert-butoxide (719mg, chemical examination is 97%, 7.25mmol); Palladium (10.2mg, 0.045mmol) and R (-)-two-tertiary butyl-[1-[(S)-and 2-(dicyclohexylphosphontetrafluoroborate)-ferrocenyl] ethyl] (25.1mg is in mixture 0.045mmol) for phosphine; Adding glycol dimethyl ether (30ml) and benzene methanamine (0.728g, 6.8mmol).Mixture is heated to 105 ℃ under fully stirring, continues 21 hours.After Hyflo
Figure S200680051127XD00441
goes up filtration; In reaction mixture impouring water (30ml); Extract with ether; With salt solution and water washing,, thereby obtain roughage through dried over sodium sulfate.With carrying out purifying on the silica gel of said roughage in ethyl acetate/hexane (1: 9), thereby obtain orange buttery expectation product (1.33g verifies as 92%, productive rate 92%).Suitable/reverse proportionality is 91: 9 (according to g.l.c.).From hexane, obtain clear crystal, m.p.87-90 ℃.
ii)(S/C?200，0.5mol％)
Use 0.005 normal palladium and 0.005 normal identical phosphine part to repeat the reaction described in above (i), thus the product that obtains expecting with 79% productive rate.
Ab) use 1,3-pair-(2, the 6-diisopropyl phenyl)-imidazolitm chloride is as part I) S/C 200, the catalyzer of 0.5mol%
5-chloro-9-sec.-propyl-benzo norbornylene [syn-enriched 91: 9 under argon gas in the Schlenk pipe; Compound N o.4.26, according to the description among the embodiment 3 preparation] (5.0g, 22.65mmol), sodium tert-butoxide (3.591g; Chemical examination is 97%, 36.2mmol), and palladium (25.4mg; 0.113mmol) and 1,3-pair-(2, the 6-diisopropyl phenyl)-imidazolitm chloride (48.1mg; 0.113mmol) mixture in, add glycol dimethyl ether (150ml) and benzene methanamine (3.641g, 34mmol).Mixture is heated to 105 ℃ under fully stirring, continues 19 hours.After Hyflo
Figure S200680051127XD00442
goes up filtration; In reaction mixture impouring water; Extract with ether; With salt solution and water washing,, thereby obtain roughage (8.53g) through dried over sodium sulfate.With carrying out purifying on the silica gel of said roughage in ethyl acetate/hexane (1: 9), expect product (6.28g verifies as 91%, and productive rate is 86%) thereby obtain orange buttery.Suitable/reverse proportionality is 89: 11 (according to g.l.c.).From hexane, carry out crystallization further to carry out syn-enriched, obtain the 3.04g clear crystal, m.p.98-100 ℃ (suitable/reverse proportionality is 98.5: 1.5).
B) from N-phenmethyl-5-amino-9-isopropylidene-benzo norbornadiene (compound No.3.12)
With N-phenmethyl-5-amino-(compound N o.3.12 for 9-isopropylidene-benzo norbornadiene; Prepare according to the description among the embodiment 5) (1.00g; 3.479mmol) be dissolved in the mixture of THF (15ml) and methyl alcohol (15ml), in the presence of the 5%Rh/C (400mg) envrionment temperature and 4 the crust under, during 24.5 hours, this mixture is carried out hydrogenation; Making moving phase with ETHYLE ACETATE-hexane (1: 9) carries out on silica gel after the purifying; Except 5-amino-5-sec.-propyl-benzo norbornylene (11%, suitable/reverse proportionality is 87: 13 (according to g.l.c.)) in addition, also obtained the expectation product (0.39g (38%) of crystalline state solid form; Suitable/reverse proportionality is 98: 2 (according to g.l.c.)).
Embodiment 5
The preparation of N-phenmethyl-5-amino-5-isopropylidene-benzo norbornadiene (compound N o.3.12)
Figure S200680051127XD00451
A) (S/C 100, the catalyzer of 1mol%)
5-chloro-9-isopropylidene-benzo norbornadiene under argon gas in the Schlenk pipe [o.5.26 compound N prepares according to the description among the embodiment 2] (1.0g, 4.61mmol); (0.731g verifies as 97% to sodium tert-butoxide, 7.38mmol), palladium (10.3mg; 0.046mmol) and 1; 3-pair-(19.6mg is in mixture 0.046mmol) for (2, the 6-diisopropyl phenyl)-imidazolitm chloride; Add diethylene glycol dimethyl ether (diglyme) (30ml) and benzene methanamine (0.741g, 6.91mmol).Mixture is heated to 140-145 ℃ under fully stirring, continues 21 hours.After Hyflo
Figure S200680051127XD00452
goes up filtration; In reaction mixture impouring water; Extract with ether; With salt solution and water washing,, thereby obtain roughage (9.54g) through dried over sodium sulfate.Said roughage is made moving phase with ethyl acetate/hexane (1: 9) on silica gel, carry out purifying, thereby obtain the expectation product (1.54g verifies as 84%, and productive rate is 98%) of yellow viscous oil shape through chromatogram.
B) S/C 400 (catalyzer of 0.25mol%)
5-chloro-9-isopropylidene-benzo norbornadiene under argon gas in the Schlenk pipe [o.5.26 compound N prepares according to the description among the embodiment 2] (5.0g, 23.07mmol); (3.548g verifies as 97% to sodium tert-butoxide, 36.9mmol), palladium (12.9mg; 0.0576mmol) and 1; 3-pair-(24.5mg is in mixture 0.0576mmol) for (2, the 6-diisopropyl phenyl)-imidazolitm chloride; Add diethylene glycol dimethyl ether (diglyme) (150ml) and benzene methanamine (3.71g, 34.6mmol).Mixture is heated to 140-145 ℃ under fully stirring, continues 24 hours.After Hyflo
Figure S200680051127XD00461
goes up filtration; In reaction mixture impouring water; Extract with ether; With salt solution and water washing, through dried over sodium sulfate.Evaporated 2 hours down at 2 millibars and 75 ℃, thereby obtain roughage (6.75g).Said roughage is made moving phase with ethyl acetate/hexane (1: 9) on silica gel, carry out purifying, thereby obtain the expectation product (6.27g verifies as 94%, and productive rate is 89%) of yellow viscous oil shape.
C) preparation of N-phenmethyl-5-amino-9-isopropylidene-benzo norbornadiene hydrochloride
Figure S200680051127XD00462
In inerted reactor, with 5-chloro-9-isopropylidene-benzo norbornadiene [o.5.26 compound N prepares according to the description among the embodiment 2] (27g; 0.125mol) be dissolved in the YLENE (125g), and add sodium tert-butoxide (15g, 0.156mol), palladium (0.22g; 0.0012mol), 1,3-is two-(2, the 6-diisopropyl phenyl)-imidazolitm chloride (0.53g; 0.0012mol) and benzene methanamine (20.1g, 0.187mol).Reaction mixture is heated to 125 ℃, continues 3 hours, accomplish up to reaction.In reaction mixture, add entry and the pH value is adjusted to 6 with HCl.Add gac, suspension-s is clarified and is separated.Steam to remove YLENE, substitute and carry out fuller's earth and handle with hexane.Isolated in form product (18.5g verifies as 94% through HPLC, and productive rate is 43%) with HCl salt.
Embodiment 6
The preparation of 5-amino-5-sec.-propyl-benzo norbornylene (suitable/the back mixing compound, syn-enriched) (compound N o.1.12)
Figure S200680051127XD00471
A) (suitable/reverse proportionality from N-phenmethyl-5-amino-5-sec.-propyl-benzo norbornylene 97: 3; Compound N o.2.12)
N-phenmethyl-5-amino-5-sec.-propyl-benzo norbornylene is [suitable/reverse proportionality 97: 3; Compound N o.2.12; Prepare according to the description among the embodiment 4] (3.00g; Chemical examination is 97%, 9.98mmol) is dissolved in the mixture of methyl alcohol (30ml) and THF (20ml), in the presence of 5%Pd/C (300mg), at ambient temperature it is carried out hydrogenation above 20 hours.Filter and evaporating solvent, thereby obtain buttery expectation aniline (2.03g verifies as 98% through g.l.c., and m.p.54-56 ℃, productive rate is 98%), suitable/reverse proportionality is 98: 2 (according to g.l.c.).
B) from N-phenmethyl-5-amino-9-isopropylidene-benzo norbornadiene (compound N o. 3.12)
With N-phenmethyl-5-amino-[compound N o.3.12 for 9-isopropylidene-benzo norbornadiene; Prepare according to the description among the embodiment 5] (1.00g; 3.479mmol) be dissolved in the mixture of THF (15ml) and methyl alcohol (15ml), under envrionment temperature and 4 crust, during 24 hours, it is being carried out thorough hydrogenation in the presence of the 5%Pd/C (400mg).Make moving phase after carrying out purifying on the silica gel with ETHYLE ACETATE-hexane (1: 9), obtain viscosity buttery expectation aniline (0.61g, 85%); Suitable/reverse proportionality is 74: 24 (according to g.l.c.).
Under envrionment temperature and 40 crust, carry out hydrogenation, other condition is identical, the aniline (0.67g, 96%) that obtains expecting with suitable/reverse proportionality of 75: 25.
Under barometric point, carry out hydrogenation, other condition is identical, and o.3.12 suitable/reverse proportionality of the productive rate with 65% and 61: 39 (according to g.l.c.) obtains compound N.
In a preferred implementation of the present invention, be used for from the method for general formula (III) compound general formula (I) compound, employed reductive agent is the hydrogen under palladium catalyst exists.
This preferred implementation can prepare formula (I) compound with simple mode, and the ratio of the trans epimer of cis epimer of its Chinese style (Ia) and formula (Ib) has been improved significantly; Usually, can obtain to surpass suitable/reverse proportionality of 55: 45; Generally can obtain suitable/reverse proportionality of 60: 40 to 99: 1.Therefore, a special advantage of this preferred implementation is, can be with the mixture of simple mode preparation I compound, and said mixture has suitable/reverse proportionality that the cis epimer is dominant.
In this preferred implementation, with general formula (III) compound according to the inventive method:
Figure S200680051127XD00481
R wherein 1And R 2Be H or C independently 1-6Alkyl, R 3Be H or C 1-4Alkyl, and Ph is phenyl,
React in the presence of palladium catalyst with hydrogen, thereby form general formula (I) compound
Figure S200680051127XD00482
R wherein 1And R 2Be H or C independently 1-6Alkyl,
And the cis epimer of its Chinese style (Ia)
Figure S200680051127XD00483
R wherein 1And R 2Define suc as formula (I) is middle,
Trans epimer with formula (Ib)
Figure S200680051127XD00491
R wherein 1And R 2Define suc as formula (I) is middle,
Between ratio greater than 55: 45.
In concrete embodiment, the compound of formula (I) is preparation like this, and the ratio of the trans epimer of cis epimer of its Chinese style (Ia) and formula (Ib) is 75: 25 to 95: 5; Be preferably 80: 20 to 95: 5; More preferably 80: 20 to 90: 10.
Suitable palladium catalyst is; For example, heterogeneous palladium catalyst is such as palladium carbon, palladium aluminum oxide, palladium silicon-dioxide, palladium barium carbonate, palladium permanent white, palladium lime carbonate or homogeneous palladium catalysts; Such as palladium, Palladous chloride, palladium hydroxide or palladous oxide, perhaps their mixture.Particularly preferably be palladium carbon.Suitable heterogeneous palladium catalyst has different water cut, and suitable palladium catalyst can have the water cut of maximum 80% (w/w).
The sufficient quantity of palladium catalyst is 0.01 to 10mol%, on the basis of formula (III) compound, calculates; Be preferably 0.1 to 1mol%.
Reaction is preferably carried out in inert solvent.The suitable solvent is, for example, alcohol, such as methyl alcohol, ethanol, propyl alcohol or Virahol, perhaps aprotic solvent, such as THF, t-butyl methyl ether, ETHYLE ACETATE, dioxane or toluene, and their mixture; Particularly preferably be ethanol or methyl alcohol.
Temperature of reaction is generally 0 ℃ to 80 ℃, and preferable range is 0 ℃ to 45 ℃, more preferably in 20 ℃ to 45 ℃ scope, even more preferably in 20 ℃ to 30 ℃ the scope.
Reaction times is generally 1 to 100 hour, is preferably 1 to 24 hour.
Reaction is preferably carried out under the pressure of 2 crust at least, the pressure of 2 to 50 crust more preferably, even the more preferably pressure of 5 to 50 crust.In an embodiment of the invention, use the pressure of 7 to 20 crust, preferred 7 to 15 crust, more preferably 8 to 12 crust.
In the specific implementations of this invention preferred implementation, reaction is in the presence of 0.01 to 10 equivalent additive, to carry out, and is preferably 0.2 to 3 equivalent.Said equivalent is a basic calculation with formula (III) compound.Suitable additive is acid or alkali.Suitable acid is inorganic acid, for example hydrochloric acid or sulfuric acid, perhaps organic acid, for example acetate, methylsulfonic acid or trifluoroacetic acid, perhaps their mixture; Methylsulfonic acid preferably.Suitable alkali is organic bases, for example organic nitrogen(ous) base.Suitable organic nitrogen(ous) base is three alkylamino alkali, for example triethylamine, Trimethylamine 99, Xu Nixi (H ü nigs) alkali, N-crassitude, N-methylmorpholine or N-methyl piperidine.
In an embodiment of this preferred implementation, use acid as additive.In another embodiment of this preferred real mode, use alkali as additive.
Through the mode of following embodiment, explained above-mentioned preferred implementation in further detail according to the inventive method.
Embodiment 7
The preparation of 5-amino-9-sec.-propyl-benzo norbornylene (suitable/the back mixing compound, syn-enriched) (mixture No.1.12)
A) test of different additive under 10 crust
With 500mg (1.7mmol) N-phenmethyl-5-amino-[compound N o.3.12 for 9-isopropylidene-benzo norbornadiene; Prepare according to the description among the embodiment 5] be dissolved in the 5ml methyl alcohol, under envrionment temperature and 10 crust, during 19 hours, it is being carried out thorough hydrogenation in the presence of the 5%Pd/C (50mg).Obtained the mixture of suitable/anti--5-amino-9-sec.-propyl-benzo norbornylene thus.Through the composition of gc evaluation response product, epimerization purity (representing) and productive rate (representing) with % with the % cis.
Acid additive The % cis The % productive rate
0.3 normal hydrochloric acid 81 85
0.75 normal hydrochloric acid 78 89
2 normal acetate 78 86
5 normal acetate 77 83
2 normal trifluoroacetic acids 81 91
5 normal trifluoroacetic acids 82 92
2 normal methylsulfonic acids 88 97
5 normal methylsulfonic acids 88 97
B) under different pressures with the test of methylsulfonic acid as additive
With 58.8g (200mmol) N-phenmethyl-5-amino-[compound N o.3.12 for 9-isopropylidene-benzo norbornadiene; Prepare according to the description among the embodiment 5] be dissolved in the methyl alcohol, in the presence of 5%Pd/C (1mol%), during 3-18 hour, it is carried out thorough hydrogenation at ambient temperature.Obtained the mixture of suitable/anti--5-amino-9-sec.-propyl-benzo norbornylene thus.Separated product, and estimate epimerization purity (representing), productive rate (representing) and purity with % with the % cis.
Pressure The % cis The % productive rate % purity
3 crust 82 94 95
6 crust 83 95 97
12 crust 81 92 92
In another preferred implementation of the present invention, be used for from the method for general formula (VI) compound general formula (IV) compound, employed reductive agent is the hydrogen under metal catalyst exists, said metal catalyst selected from rhodium, palladium and platinum.
This preferred implementation can prepare formula (IV) compound, the cis epimer of its Chinese style (IVa) with simple mode
Figure S200680051127XD00521
Trans epimer with formula (IVb)
Figure S200680051127XD00522
Between ratio improved significantly; Usually, can obtain to surpass suitable/reverse proportionality of 55: 45; Generally can obtain suitable/reverse proportionality of 60: 40 to 99: 1.Therefore, a special advantage of this preferred implementation is, can prepare the mixture of formula IV compound with simple mode, and said mixture has suitable/reverse proportionality that the cis epimer is dominant.
In this preferred implementation, with general formula (IV) compound according to the inventive method:
Figure S200680051127XD00523
R wherein 1And R 2Be H or C independently 1-6Alkyl and X are chlorine or bromines,
React in the presence of the catalyzer of selected from rhodium, palladium and platinum with hydrogen, thereby form general formula (IV) compound
R wherein 1And R 2Be H or C independently 1-6Alkyl and X are chlorine or bromines,
And the cis epimer of its Chinese style (IVa)
Figure S200680051127XD00531
R wherein 1, R 2Define suc as formula (VI) is middle with X,
Trans epimer with formula (IVb)
Figure S200680051127XD00532
R wherein 1, R 2Define suc as formula (VI) is middle with X,
Between ratio greater than 55: 45.
In concrete embodiment, the compound of formula (I) is preparation like this, and the ratio of the trans epimer of cis epimer of its Chinese style (Ia) and formula (Ib) is 75: 25 to 98: 2; Be preferably 80: 20 to 95: 5; More preferably 90: 10 to 95: 5.
In a preferred implementation, X is a chlorine.
Suitable rhodium catalyst is, for example, and rhodium carbon, rhodium aluminum oxide or rhodium oxide (III).Rhodium carbon preferably.Suitable palladium catalyst is, for example, and heterogeneous palladium catalyst; Such as palladium carbon, palladium aluminum oxide, palladium silicon-dioxide, palladium barium carbonate, palladium permanent white, palladium lime carbonate; Perhaps homogeneous palladium catalysts, such as palladium, Palladous chloride, palladium hydroxide or palladous oxide, perhaps their mixture.Particularly preferably be palladium carbon.Suitable platinum catalyst is, for example, and platinum carbon or platinum oxide (IV).Particularly preferably be platinum carbon.
In an embodiment of this invention preferred implementation, catalyzer is a rhodium carbon.
In another embodiment of this invention preferred implementation, catalyzer is a palladium carbon.
In an embodiment of this invention preferred implementation, catalyzer is a platinum carbon.
The suitable amount of catalyzer is 0.01 to 10mol%, is basic calculation with formula (III) compound, is preferably 0.1 to 1mol%.
Reaction is preferably carried out in inert solvent.The suitable solvent is, for example, alcohol, such as methyl alcohol, ethanol, propyl alcohol or Virahol, perhaps aprotic solvent, such as THF, t-butyl methyl ether, ETHYLE ACETATE, dioxane or toluene, and their mixture; Particularly preferably be ethanol or methyl alcohol.
Temperature of reaction is generally 0 ℃ to 80 ℃, and preferable range is 0 ℃ to 45 ℃, more preferably in 20 ℃ to 45 ℃ scope, even more preferably in 20 ℃ to 30 ℃ the scope.
Reaction times is generally 1 to 100 hour, is preferably 1 to 24 hour.
Reaction is preferably carried out under the pressure of 2 crust at least, the pressure of 2 to 50 crust more preferably, even the more preferably pressure of 5 to 50 crust.In an embodiment of the invention, use the pressure of 7 to 20 crust, preferred 7 to 15 crust, more preferably 8 to 12 crust.
In the specific implementations of this invention preferred implementation, reaction is in the presence of 0.01 to 10 equivalent additive, to carry out, and is preferably 0.2 to 3 equivalent.Said equivalent is a basic calculation with formula (III) compound.Suitable additive is acid or alkali.Suitable acid is inorganic acid, for example hydrochloric acid or sulfuric acid, perhaps organic acid, for example acetate, methylsulfonic acid or trifluoroacetic acid, perhaps their mixture; Preferred acid is hydrochloric acid, acetate, methylsulfonic acid or trifluoroacetic acid.Suitable alkali is organic bases, for example organic nitrogen(ous) base.Suitable organic nitrogen(ous) base is three alkylamino alkali, for example triethylamine, Trimethylamine 99, Xu Nixi (H ü nigs) alkali, N-crassitude, N-methylmorpholine or N-methyl piperidine.
In an embodiment of this preferred implementation, use acid as additive.In another embodiment of this preferred real mode, use alkali as additive.
Through the mode of following embodiment, explained above-mentioned preferred implementation in further detail according to the inventive method.
Embodiment 8
The preparation of 5-chloro-9-sec.-propyl-benzo norbornylene (suitable/the back mixing compound, syn-enriched) (compound N o.4.26)
Figure S200680051127XD00541
A) use Pd/C as catalyzer, do not use additive
300mg (1.4mmol) 5-chloro-9-isopropylidene-benzo norbornadiene (preparing according to the description among the embodiment 2) is dissolved in the 3ml methyl alcohol, under envrionment temperature and 10 crust, during 16 hours, it is being carried out thorough hydrogenation in the presence of the 5%Pd/C (9mg).Obtained mixture (the epimerization purity: 93% cis of suitable/anti--5-chloro-9-sec.-propyl-benzo norbornylene thus; Productive rate 85%).Through the composition of gc evaluation response product, epimerization purity (representing) and productive rate (representing) with % with the % cis.
B) use different additive test Pd/C
300mg (1.4mmol) 5-chloro-9-isopropylidene-benzo norbornadiene (according to the description among the embodiment 2 preparation) is dissolved in the 3ml methyl alcohol, in the presence of the 5%Pd/C (9mg) envrionment temperature and 10 crust down during 16 hours to its capable thorough hydrogenation.Obtained the mixture of suitable/anti--5-chloro-9-sec.-propyl-benzo norbornylene thus.Through the composition of gc evaluation response product, epimerization purity (representing) and productive rate (representing) with % with the % cis.
Acid additive The % cis The % productive rate
0.5 normal hydrochloric acid 92 89
2 normal methylsulfonic acids 92 89
2 normal acetate 94 80
C) use different additive test Pt/C
300mg (1.4mmol) 5-chloro-9-isopropylidene-benzo norbornadiene (preparing according to the description among the embodiment 2) is dissolved in the 3ml methyl alcohol, under envrionment temperature and 10 crust, during 16 hours, it is being carried out thorough hydrogenation in the presence of the 5%Pt/C (15mg).Obtained the mixture of suitable/anti--5-chloro-9-sec.-propyl-benzo norbornylene thus.Through the composition of gc evaluation response product, epimerization purity (representing) and productive rate (representing) with % with the % cis.
Acid additive The % cis The % productive rate
0.5 normal hydrochloric acid 94 95
Acid additive The % cis The % productive rate
2 normal methylsulfonic acids 94 94
2 normal acetate 94 94
2 normal trifluoroacetic acids 94 94

Claims (13)

1. the preparation method of a general formula (I) compound:
Figure FSB00000755669500011
R wherein 1And R 2Be H or C independently 1-6Alkyl, said method comprise with reductive agent handles general formula (II) compound:
Figure FSB00000755669500012
R wherein 1And R 2Has given implication in formula (I) compound, R 3Be H or C 1-4Alkyl, and Ph is phenyl, perhaps
Handle general formula (III) compound:
R wherein 1, R 2, R 3Have above given implication with Ph, said reductive agent makes phenmethyl part Ph-CH (R effectively 3The amino part PhCH of the phenmethyl of)-from formula (II) compound or formula (III) compound (R 3) thereby the last cracking of NH-stays amino, in addition, for formula (III) compound, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
2. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with general formula (IV) compound:
Figure FSB00000755669500021
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine, and the benzene methanamine of logical formula V:
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
Figure FSB00000755669500023
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(b) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
3. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with general formula (VI) compound:
Figure FSB00000755669500031
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine, and the benzene methanamine of logical formula V:
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure FSB00000755669500033
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(b) handle formed general formula (III) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, and effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
4. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) handle general formula (VI) compound with reductive agent:
Figure FSB00000755669500041
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine, and said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, thereby form general formula (IV) compound, and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists:
Figure FSB00000755669500042
R wherein 1And R 2Have implication given in the claim 1 and X and have above given implication;
(b) with the benzene methanamine of formed general formula (IV) compound and logical formula V:
Figure FSB00000755669500043
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(c) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
5. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with general formula (VI) compound:
Figure FSB00000755669500051
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine, and the benzene methanamine of logical formula V:
Figure FSB00000755669500052
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure FSB00000755669500053
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph;
(b) handle formed general formula (III) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, but have kept PhCH (R 3) NH-part complete, thereby forming general formula (II) compound, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists:
Figure FSB00000755669500061
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(c) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
6. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Figure FSB00000755669500062
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With the organo-metallic material, wherein said organo-metallic material is C 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Figure FSB00000755669500063
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure FSB00000755669500064
R wherein 1And R 2Have above given implication,
In inert organic solvents, react, thus the compound of formation general formula (VI):
Figure FSB00000755669500071
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine;
(c) with the benzene methanamine of formed general formula (VI) compound and logical formula V:
Figure FSB00000755669500072
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(d) handle formed general formula (III) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, and can be effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
7. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Figure FSB00000755669500081
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With the organo-metallic material, wherein said organo-metallic material is C 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Figure FSB00000755669500082
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure FSB00000755669500083
R wherein 1And R 2Have implication given in the claim 1,
In inert organic solvents, react, thus the compound of formation general formula (VI):
Figure FSB00000755669500084
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine;
(c) handle formed general formula (VI) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, thereby form the compound of general formula (IV), and wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists:
Figure FSB00000755669500091
R wherein 1And R 2Have implication given in the claim 1 and X and have above given implication;
(d) with the benzene methanamine of formed general formula (IV) compound and logical formula V:
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (II) compound:
Figure FSB00000755669500093
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(e) handle formed general formula (II) compound with reductive agent, said reductive agent can make phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
8. according to the preparation method of general formula (I) compound of claim 1, said method comprises the steps:
(a) with formula (IX) or (X) 1,2, the 3-trihalogenated benzene:
Wherein X is that chlorine or bromine and Y are bromine or iodines,
With the organo-metallic material, wherein said organo-metallic material is C 1-6Alkyl-or phenyl lithium or C 1-6The alkyl or phenyl magnesium halide reacts under inert atmosphere, thereby forms the halo benzyne of general formula (VII):
Figure FSB00000755669500102
Wherein X is a chlorine or bromine;
(b) with the halo benzyne of formed general formula (VII) and the fulvene of general formula (VIII):
Figure FSB00000755669500103
R wherein 1And R 2Have implication given in the claim 1,
In inert organic solvents, react, thus the compound of formation general formula (VI):
Figure FSB00000755669500104
R wherein 1And R 2Having implication given in the claim 1 and X is chlorine or bromine;
(c) with the benzene methanamine of formed general formula (VI) compound and logical formula V:
Figure FSB00000755669500105
R wherein 3Be H or C 1-4Alkyl and Ph are phenyl,
In the presence of at least a palladium complex of alkali and catalytic amount, react, thereby form general formula (III) compound:
Figure FSB00000755669500111
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph;
(d) handle formed general formula (III) compound with reductive agent, said reductive agent is effectively with 2, two keys of 3-and with R 1R 2Two keys that C-partly is connected on the benzo norbornylene ring 9-position all are reduced into singly-bound, but have kept PhCH (R 3) NH-part complete, thereby forming general formula (II) compound, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists:
Figure FSB00000755669500112
R wherein 1And R 2Have implication given in the claim 1 and R 3Has above given implication with Ph; With
(e) handle formed general formula (II) compound with reductive agent, said reductive agent makes phenmethyl part Ph-CH (R effectively 3)-from the amino part PhCH of phenmethyl (R 3) thereby the last cracking of NH-stays amino, wherein said reductive agent is the hydrogen under metal hydrogenation catalyst exists.
9. general formula (II) or compound (III):
Figure FSB00000755669500121
R wherein 1And R 2Be H or C independently 1-6Alkyl, R 3Be H or C 1-4Alkyl and Ph are phenyl.
10. according to the process of claim 1 wherein with general formula (III) compound:
Figure FSB00000755669500122
R wherein 1And R 2Be H or C independently 1-6Alkyl, R 3Be H or C 1-4Alkyl, and Ph is phenyl,
React in the presence of palladium catalyst with hydrogen, thereby form general formula (I) compound
Figure FSB00000755669500123
R wherein 1And R 2Be H or C independently 1-6Alkyl,
And the cis epimer of its Chinese style (Ia)
R wherein 1And R 2Define suc as formula (I) is middle,
Trans epimer with formula (Ib)
Figure FSB00000755669500131
R wherein 1And R 2Define suc as formula (I) is middle,
Ratio greater than 55: 45.
11. according to the method for claim 10, wherein said method is in the presence of additive, to carry out.
12. according to the method for claim 10, wherein said method is under 0 ℃ to 80 ℃ temperature, to carry out.
13. according to the method for claim 10, wherein said method is under the pressure of at least 2 crust, to carry out.
CN200680051127XA 2005-12-12 2006-12-11 Process for the preparation of amines Active CN101360703B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05027072.7 2005-12-12
EP05027072 2005-12-12
EP06008248 2006-04-21
EP06008248.4 2006-04-21
PCT/EP2006/011885 WO2007068417A2 (en) 2005-12-12 2006-12-11 Process for the preparation of amines

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201110318357.0A Division CN102516086B (en) 2005-12-12 2006-12-11 Process for the preparation of amines
CN201410401736.XA Division CN104151132B (en) 2005-12-12 2006-12-11 The preparation method of amine

Publications (2)

Publication Number Publication Date
CN101360703A CN101360703A (en) 2009-02-04
CN101360703B true CN101360703B (en) 2012-07-18

Family

ID=37946810

Family Applications (3)

Application Number Title Priority Date Filing Date
CN200680051127XA Active CN101360703B (en) 2005-12-12 2006-12-11 Process for the preparation of amines
CN201410401736.XA Active CN104151132B (en) 2005-12-12 2006-12-11 The preparation method of amine
CN201110318357.0A Active CN102516086B (en) 2005-12-12 2006-12-11 Process for the preparation of amines

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201410401736.XA Active CN104151132B (en) 2005-12-12 2006-12-11 The preparation method of amine
CN201110318357.0A Active CN102516086B (en) 2005-12-12 2006-12-11 Process for the preparation of amines

Country Status (21)

Country Link
US (1) US7781615B2 (en)
EP (5) EP2316814A1 (en)
JP (1) JP5144533B2 (en)
KR (1) KR101364220B1 (en)
CN (3) CN101360703B (en)
AR (1) AR058302A1 (en)
AU (1) AU2006326289B2 (en)
BR (1) BRPI0619629B1 (en)
CA (1) CA2631973C (en)
CL (2) CL2010000015A1 (en)
CR (1) CR10052A (en)
DK (1) DK1963251T3 (en)
EA (1) EA014275B1 (en)
EC (1) ECSP088525A (en)
EG (1) EG25547A (en)
ES (1) ES2391904T3 (en)
IL (3) IL191760A (en)
IN (1) IN2015DN00818A (en)
PL (1) PL1963251T3 (en)
TW (1) TWI396676B (en)
WO (1) WO2007068417A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104151132B (en) * 2005-12-12 2016-07-06 先正达参股股份有限公司 The preparation method of amine

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2614716A1 (en) 2007-09-20 2013-07-17 Basf Se Combinations comprising a fungicidal strain and at least one additional fungicide
EA020599B1 (en) 2008-07-04 2014-12-30 Басф Се Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides and abamectin
GEP20135747B (en) 2008-10-27 2013-02-11 Syngenta Participations Ag Method of benzonorbornenes production
EP2373625B1 (en) 2008-12-24 2014-10-08 Syngenta Limited Methods for the preparation of aryl amides
EP2560960B1 (en) * 2010-04-20 2014-02-26 Syngenta Participations AG Process for the preparation of pyrazole carboxylic acid amides
WO2012065947A1 (en) 2010-11-15 2012-05-24 Bayer Cropscience Ag 5-halogenopyrazolecarboxamides
RU2493145C1 (en) * 2012-10-02 2013-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Method of producing 2-(aminoalkyl)-3-(aminophenyl)bicyclo[2,2,1]heptanes
MY182216A (en) * 2013-03-14 2021-01-18 Dow Agrosciences Llc Broadleaf crop control with 6-arylpicoline carboxylic acids, 2-arylpyrimidine carboxylic acids, or salts or esters thereof
US11560384B2 (en) 2017-05-04 2023-01-24 University Of Utah Research Foundation Benzonorbornadiene derivatives and reactions thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1086978A (en) * 1965-09-21 1967-10-11 Shionogi & Co Improvements in or relating to the preparation of 7-oxobenzonorbornene derivatives
JPH075487B2 (en) 1985-11-14 1995-01-25 住友化学工業株式会社 Method for producing 1-bromo-2-chloro-4-fluorobenzene
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
CN1896048A (en) * 2001-03-16 2007-01-17 出光兴产株式会社 Process for producing aromatic amino compound
JP4219622B2 (en) * 2002-06-11 2009-02-04 独立行政法人科学技術振興機構 New production method for benzyne compounds
ATE516275T1 (en) * 2002-08-22 2011-07-15 Syngenta Participations Ag MICROBIOCIDES (E.G. FUNGICIDES) 1,2,3-TRIAZOLE DERIVATIVES
GB0224316D0 (en) 2002-10-18 2002-11-27 Syngenta Participations Ag Chemical compounds
EP2316814A1 (en) * 2005-12-12 2011-05-04 Syngenta Participations AG Process for preparation of halogen substituted benzonorbornenes derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104151132B (en) * 2005-12-12 2016-07-06 先正达参股股份有限公司 The preparation method of amine

Also Published As

Publication number Publication date
IL191760A (en) 2014-05-28
EP2316814A1 (en) 2011-05-04
EP1963251B1 (en) 2012-08-15
PL1963251T3 (en) 2013-01-31
US20090221856A1 (en) 2009-09-03
US7781615B2 (en) 2010-08-24
IL191760A0 (en) 2008-12-29
CN102516086B (en) 2014-10-22
WO2007068417A2 (en) 2007-06-21
AU2006326289B2 (en) 2011-12-22
EG25547A (en) 2012-02-15
EP2316809A1 (en) 2011-05-04
AR058302A1 (en) 2008-01-30
TWI396676B (en) 2013-05-21
EP1963251A2 (en) 2008-09-03
BRPI0619629A2 (en) 2011-10-04
JP2009518346A (en) 2009-05-07
CN104151132B (en) 2016-07-06
DK1963251T3 (en) 2012-11-26
IN2015DN00818A (en) 2015-07-10
EP2316815A1 (en) 2011-05-04
ES2391904T3 (en) 2012-11-30
ECSP088525A (en) 2008-07-30
EP2316809B1 (en) 2014-06-18
AU2006326289A1 (en) 2007-06-21
BRPI0619629B1 (en) 2016-03-01
EA200870038A1 (en) 2008-10-30
WO2007068417A3 (en) 2007-10-04
CL2010000015A1 (en) 2010-07-02
CN102516086A (en) 2012-06-27
CL2012000114A1 (en) 2012-08-31
EP2316813B1 (en) 2013-04-03
CA2631973A1 (en) 2007-06-21
TW200800854A (en) 2008-01-01
EP2316813A1 (en) 2011-05-04
JP5144533B2 (en) 2013-02-13
CN101360703A (en) 2009-02-04
IL218351A0 (en) 2012-04-30
KR20080077011A (en) 2008-08-20
KR101364220B1 (en) 2014-02-21
CA2631973C (en) 2015-02-03
CN104151132A (en) 2014-11-19
EA014275B1 (en) 2010-10-29
IL218350A0 (en) 2012-04-30
IL218351A (en) 2014-05-28
CR10052A (en) 2008-09-17

Similar Documents

Publication Publication Date Title
CN101360703B (en) Process for the preparation of amines
TWI428324B (en) Process for the preparation of pyrazole carboxylic acid amides
TW201210590A (en) Process for the preparation of pyrazole carboxylic acid amides
JP5139295B2 (en) Method for producing aniline
CN101309907B (en) Process for the production of carboxanilides
AU721564B2 (en) Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
US6552239B1 (en) Synthesis of cyclopropaneacetylene by a one-pot process
JP2023130810A (en) Method for producing fluorine-containing compound

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant