CN1013579B - Process for producing rutin - Google Patents
Process for producing rutinInfo
- Publication number
- CN1013579B CN1013579B CN 87103731 CN87103731A CN1013579B CN 1013579 B CN1013579 B CN 1013579B CN 87103731 CN87103731 CN 87103731 CN 87103731 A CN87103731 A CN 87103731A CN 1013579 B CN1013579 B CN 1013579B
- Authority
- CN
- China
- Prior art keywords
- rutin
- water
- technology
- ammonium bicarbonate
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 title claims abstract description 24
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 title claims abstract description 24
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 title claims abstract description 24
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 235000005493 rutin Nutrition 0.000 title claims abstract description 24
- 229960004555 rutoside Drugs 0.000 title claims abstract description 24
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 title claims description 20
- 238000000034 method Methods 0.000 title claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims abstract description 6
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims abstract description 5
- 239000001099 ammonium carbonate Substances 0.000 claims abstract description 5
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims abstract description 4
- 235000011941 Tilia x europaea Nutrition 0.000 claims abstract description 4
- 239000004571 lime Substances 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 241000219784 Sophora Species 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000010411 cooking Methods 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000005554 pickling Methods 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000004945 emulsification Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 6
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 2
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 abstract 5
- 235000010586 Sophora japonica Nutrition 0.000 abstract 1
- 244000046101 Sophora japonica Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 238000013019 agitation Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a technology for producing rutin, which is a chemical technology for extracting rutin form buds of Chinese scholartree. The technology is characterized in that a small amount of lime water is added instead of lime milk water to aqueous ammonium bicarbonate solution to be steamed, cool water is used instead of warmed water to wash raw materials, and crystallized rutin is not washed by using acid water. Ammonium bicarbonate with a small amt. Compared with a conventional technology for producing rutin. The technology has obvious advantages of high rutin yield, good quality, little energy consumption, etc.
Description
The rutin production method is meant a kind of chemical industry method of extracting rutin from the sophora bud.
Rutin can also can be used as the intermediate of medicine, dyestuff and the additive of food directly as medicine.Traditional process for producing rutin is earlier the raw material sophora bud to be pulverized, through making the finished product rutin after the operations such as warm water washing, the boiling of hot lime whey, purification, neutralization, cooling, filtration, pickling, washing, oven dry, pulverizing, sometimes also to just can obtain qualified product through the treating process second time.The shortcoming of this technical process is, rutin yield is low, only is 8%-12%, and it is faint yellow that product is, and residue on ignition is often higher.For this reason, proposed production method of the present invention, it is characterized in that,, added a small amount of liming with ammonium bicarbonate aqueous solution and come the boiling of replacing lime whey, when the washing sophora bud, replaced warm water with cold water at cooking process; When the wash crystallization rutin, remove sour water from.The trial production result, rutin yield can reach 13%-17%, has improved 20%-40% than traditional technology, and quality product has also improved, and especially residue on ignition obviously descends, and the finished product rutin is distinctive little green-yellow; Owing to use cold water washing, can save energy about 50%, reduced the consumption of industrial chemicals, simplified operating process.
Embodiment:
Sophora bud 50kg after having pulverized adds water 1000kg and under agitation washs, totally three times.Add the about 1000kg of water more under agitation, begin to add steam and heat up, it is some to add about 15kg saturated limewater and ammonium bicarbonate aqueous solution simultaneously.In adding the diminishing process, ceaselessly stir, and the pH value of limit edged inspection extracting solution, make when extracting solution seethes with excitement, to keep pH8.5-9.0, add the 0.2kg borax again.Be incubated half an hour under boiling, leach sophora bud slag, soup carries out purifying treatment with pressure by 10 layers of cloth bag.In soup, add the dilute hydrochloric acid neutralization, equal 6 to the pH value of solution, and cooling under agitation, placement is spent the night, and makes the rutin precipitation complete.Leach precipitation with the plate and frame filter, washed about 2.5 hours with softening water, after the centrifuge dehydration, oven dry through pulverizing, promptly gets the rutin finished product again in about 80 ℃.
Above-mentioned sophora bud slag adds water 800kg again, saturated limewater 2kg, and borax 0.2kg repeats above operating process, obtains the rutin finished product once more.
Merge the above-mentioned two altogether 7.1kg of rutin finished product that take second place, yield 14.2%, product is by " Drug Standard of Ministry of Public Health of the Peoples Republic of China (1963) " chemical examination, rutin content 95.1%, moisture 8.7%, insolubles 5.5mg in the ethanol, residue on ignition 0.42%.
Claims (2)
1, a kind of chemical industry method of from the sophora bud, extracting rutin, traditional technical process is, sophora bud pulverizing → warm water washing → lime emulsification boiling → purification → neutralization → cooling → filtration → pickling → wash → dry → pulverize the finished product rutin, it is characterized in that, at cooking process, with be ammonium bicarbonate aqueous solution and a small amount of liming, the pH value of using bicarbonate of ammonia control solution is between 8.5-9.0.
2, according to the rutin production method of claim 1, wherein washing procedure is characterized in that carrying out with cold water when washing material, only carries out with softening water during the wash crystallization rutin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87103731 CN1013579B (en) | 1987-05-25 | 1987-05-25 | Process for producing rutin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87103731 CN1013579B (en) | 1987-05-25 | 1987-05-25 | Process for producing rutin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1030764A CN1030764A (en) | 1989-02-01 |
| CN1013579B true CN1013579B (en) | 1991-08-21 |
Family
ID=4814559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87103731 Expired CN1013579B (en) | 1987-05-25 | 1987-05-25 | Process for producing rutin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1013579B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9827262B2 (en) | 2012-10-22 | 2017-11-28 | Alps Pharmaceuticals, Ind. Co., Ltd. | Rutin-rich extract and method of making same |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052983C (en) * | 1998-07-28 | 2000-05-31 | 中国科学院昆明植物研究所 | Melim sulfate compound |
| CN102807596A (en) * | 2012-08-23 | 2012-12-05 | 四川省砚山中药饮片有限公司 | Method for extracting rutin |
| CN105949255A (en) * | 2016-05-11 | 2016-09-21 | 驻马店天中生物科技有限公司 | Extracting method of rutin |
| CN111635443A (en) * | 2020-06-15 | 2020-09-08 | 深圳市蜜踪生物科技有限公司 | Sophora flower extraction process |
-
1987
- 1987-05-25 CN CN 87103731 patent/CN1013579B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9827262B2 (en) | 2012-10-22 | 2017-11-28 | Alps Pharmaceuticals, Ind. Co., Ltd. | Rutin-rich extract and method of making same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1030764A (en) | 1989-02-01 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C13 | Decision | ||
| GR02 | Examined patent application | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |