CN101357143A - Probiotics powder composition and product thereof - Google Patents
Probiotics powder composition and product thereof Download PDFInfo
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- CN101357143A CN101357143A CNA2007101431705A CN200710143170A CN101357143A CN 101357143 A CN101357143 A CN 101357143A CN A2007101431705 A CNA2007101431705 A CN A2007101431705A CN 200710143170 A CN200710143170 A CN 200710143170A CN 101357143 A CN101357143 A CN 101357143A
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- probiotic bacteria
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- lactobacillus
- bifidobacterium
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Abstract
The invention discloses a probiotic bacteria powder composition and a product thereof, wherein, the probiotic bacteria powder composition is made by a method that a probiotic bacteria which has the functions of intestinal canal adsorption and PBMC (peripheral blood corpuscle cells of human being) analysis and can reduce allergy is combined with the same or another probiotic bacteria which can inhibit helicobacter pylori, and then the mycelium is embedded by making use of a wall material prescription, and finally frozen and dried to form the probiotic bacteria powder composition, while the probiotic bacteria product is prepared in a way that at least one kind of probiotic bacteria is homogeneously emulsified with grease and an antioxidant, emulsified with a dissolved membrane, and then filled into a dosage form of soft capsule; and the probiotic bacteria powder composition has the advantages of easy acquirability of raw materials and simple process, in addition, the probiotic bacteria product has the advantages of stable quality and easy conservation, so that the active bacteria can be fully retained and quickly restored to the stable state in the stomach acid environment; the method thereof can also protect the mycelium from being damaged by stomach acid and bile salt, and can be fully used in preparing similar formulations.
Description
Technical field
The present invention particularly about a kind of probiotics powder composition and probiotic composition, becomes at least a probiotic bacteria powder the probiotic composition of capsule formulation about a kind of goods of probiotic bacteria with the grease emulsifying embedding.
Background technology
Probiotic bacteria (Probiotics) word is derived from Greek, former meaning " to life useful " the meaning, probiotic bacteria is distributed in human body intestinal canal more, extensively comprise lactobacillus (Lactobacillus species), lactic acid coccus (Lactococcusspecies), enterococcus (Entrococcus species), bacillus bifidus Pseudomonas (Bifidobacterium species) part strain and part yeast multiple mushrooms such as (yeast), Russia scientist Ellie Metchnikoff (1845-1916) finds that the microorganism in the yoghourt can suppress the growth of intestinal putrefaction bacteria, can reduce toxicant, health to human body has marvellous effect, and therefore obtains Nobel Prize in 1908.
Distribution has the bacterial strain more than 400 kinds approximately in the human body intestinal canal, its bacterium can be subjected to dietary habit mutually, age, factor affecting such as environment, research is at present summarized probiotic bacteria and is had enhancing immunity, reduce irritated, improve Asians's lactose intolerance, lower vagina and urinary tract infection, cholesterol reducing, facilitating digestion, improve Helicobacter pylori infection and prevention of osteoporosis and carry effects such as disease, therefore constantly change in social formation now, life is nervous busy, the dietetic nutrition imbalance, under the insufficient environment of long-term motion, various probiotic compositions are constantly weeded out the old and bring forth the new, the most general common be beverage product or the food composition thing that is added with probiotic bacteria.
But utilize above-mentioned method,, still have the harsh requirement of preservation condition, and the pot-life is very limited more though probiotic bacteria is coated in the microcapsule to keep its stability; Simultaneously, also have Producer that the probiotic bacteria powder is coated in the common hard capsule, but this method is after the hard capsule disintegrate, active thalline quantity can reduce fast, it is limited really to enter the bacterium number that intestinal plays a role, and can't play one's part to the full, and reaches the effect of adjusting bacterium phase in the intestinal.
Australia pathologist Hua Lun and Marshall are found (the Helicobacter pylori that exists of Helicobacter pylori during nineteen eighty-two, also can claim the HP bacterium), find out this bacterium and gastric ulcer simultaneously, the significant correlation of duodenal ulcer, therefore and obtained the special honours of Nobel Prize in 2005, the known Helicobacter pylori of correlational study has 4-5 bar flagellum at present, can secrete special urease and gastric mucosa ferment, make this bacterium have the ability of destroying gastric mucosa, after gastric mucosa is destroyed, by the adhesin effect, and be adsorbed in the gastric epithelial cells surface, World Health Organization (WHO) then classified Helicobacter pylori as first kind carcinogen in 1994, offered some clarification on the relation of digestive tract disease such as Helicobacter pylori and gastric cancer, the sequela that therefore how to lower the intestines and stomach disease that causes because of Helicobacter pylori and initiation is just very important.
In sum, at present the prior art that adopts all still remains to be improved part, the present inventor is because every disappearance of above-mentioned existing probiotic composition, be urgently to think improvement and invent out a kind of being easy to and preserve, and manage to regulate the reduction Helicobacter pylori and infect, and can keep the mycopowder constituent and the goods thereof of maximum probiotic active by body constitution.
Summary of the invention
Primary and foremost purpose of the present invention is to provide a kind of probiotics powder composition, wherein probiotics powder composition has intestinal adsorption function and PBMC (human peripheral blood glomus cell) analysis and can lower irritated probiotic bacteria for utilizing, and in conjunction with suppressing helicobacter pylori (Helicobacter pylori, also can claim the HP bacterium) same or another probiotic bacteria, behind a wall material formula embedding thalline, form probiotics powder composition in the lyophilization mode.
Another object of the present invention is to provide a kind of probiotic composition, comprise at least a probiotic bacteria powder, and filling becomes the dosage form of soft capsule; In addition, it also is a kind of novel form that gastric acid and cholate is had good tolerance probiotic composition.
To achieve these goals, the technical solution used in the present invention is:
A kind of probiotics powder composition comprises a kind of probiotic bacteria, and it is the probiotic bacteria that utilizes intestinal absorption and can lower allergy, inhibition helicobacter pylori;
Perhaps comprise a kind of probiotic bacteria, it utilizes intestinal absorption and can lower a probiotic bacteria hypersensitive and another kind of probiotic bacteria for a kind of, and it is for suppressing the probiotic bacteria of helicobacter pylori;
And utilize a wall material formula and those probiotic bacterias in thalline embedding mode, form a probiotics powder composition through a lyophilization.
Lyophilization of the present invention comprises vacuum lyophilization and pump type heat lyophilization.
Described wall material formula is the mixture of an oils and fats, trehalose, sodium alginate, pectin, glycerol.
Described probiotic bacteria comprises the Lactobacillus acidophilus (Lactobacillus acidophilus) of genus lactubacillus, short lactobacillus (Lactobacillus brevis), acid kefir milk acidfast bacilli (Lactobacillus fermentum), secondary Lactobacillus casei (Lactobacillus paracasei spp.paracasei), lactobacillus plantarum (Lactobacillus plantarum), rhamnose lactic acid bacteria (Lactobacillus rhamnosus), saliva lactobacillus (Lactobacillus salivarius), lactobacillus gasseri (Lactobacillus gasseri), Switzerland's lactobacillus (Lactobacillus helveticus) or Lactobacillus casei (Lactobacillus casei).
Probiotic bacteria of the present invention comprises the bifidobacterium (Bifidobacterium bifidum) of Bifidobacterium, microscler bacillus bifidus (Bifidobacterium longum), baby's bifidobacterium (Bifidobacterium infantis), short bifidobacterium (Bifidobacterium breve) or newborn bifidobacterium (Bifidobacterium lactis).
Described probiotic bacteria comprises Apis enterococcus faecalis (Enterococcus faecium) or enterococcus faecalis (Enterococcusfaecalis).
Described oils and fats comprises that middle chain fatty, Petiolus Trachycarpi oil, cotton fatty oil or honey are cured.
A kind of probiotic composition comprises at least a probiotic bacteria, after this probiotic bacteria and an oils and fats and the antioxidant emulsifying, and with a dissolved epithelium mixing and emulsifying, refill the dosage form that is shaped to a soft capsule.
Described oils and fats comprises that middle chain fatty, Petiolus Trachycarpi oil, cotton fatty oil or honey are cured.
The source of described probiotic bacteria comprises the mycopowder through the thalline embedding.
Described probiotic bacteria comprises the Lactobacillus acidophilus of genus lactubacillus, short lactobacillus, sour kefir milk acidfast bacilli, secondary Lactobacillus casei, lactobacillus plantarum, rhamnose lactic acid bacteria, saliva lactobacillus, lactobacillus gasseri, Switzerland's lactobacillus or Lactobacillus casei.
Described probiotic bacteria comprises the bifidobacterium of Bifidobacterium, microscler bacillus bifidus, baby's bifidobacterium, short bifidobacterium or newborn bifidobacterium.
Described probiotic bacteria comprises Apis enterococcus faecalis or enterococcus faecalis.
Described oils and fats can mix with trehalose, sodium alginate, pectin, glycerol.
A kind of probiotics powder composition, comprise and utilize intestinal absorption and can lower a probiotic bacteria hypersensitive in conjunction with suppressing the same of helicobacter pylori or another probiotic bacteria, utilize a wall material formula and those probiotic bacterias in thalline embedding mode, form a probiotics powder composition through a lyophilization.
Preferred embodiment according to probiotics powder composition of the present invention and probiotic composition is described, and wherein this wall material formula is included as the mixture of an oils and fats, trehalose, sodium alginate, pectin, glycerol.
Probiotic composition of the present invention comprises after at least a probiotic bacteria or its mycopowder, an oils and fats and the antioxidant emulsifying, again with dissolved epithelium emulsifying after, filling forms the probiotic composition of soft capsule dosage form.
Preferred embodiment according to probiotics powder composition of the present invention and probiotic composition is described, and wherein spendable probiotic bacteria kind for example is the Lactobacillus acidophilus (Lactobacillus acidophilus) of genus lactubacillus, short lactobacillus (Lactobacillus brevis), acid kefir milk acidfast bacilli (Lactobacillus fermentum), secondary Lactobacillus casei (Lactobacillus paracasei spp.paracasei), lactobacillus plantarum (Lactobacillus plantarum), rhamnose lactic acid bacteria (Lactobacillus rhamnosus), saliva lactobacillus (Lactobacillus salivarius), lactobacillus gasseri (Lactobacillus gassert), Switzerland's lactobacillus (Lactobacillus helveticus), Lactobacillus casei strains such as (Lactobacillus casei).
Preferred embodiment according to probiotics powder composition of the present invention and probiotic composition is described, and wherein spendable probiotic bacteria kind for example is the bifidobacterium (Bifidobacterium bifidum) of Bifidobacterium, microscler bacillus bifidus (Bifidobacterium longum), baby's bifidobacterium (Bifidobacterium infantis), short bifidobacterium (Bifidobacterium breve) or newborn bifidobacterium strains such as (Bifidobacterium lactis).
Preferred embodiment according to probiotics powder composition of the present invention and probiotic composition is described, and wherein spendable probiotic bacteria kind for example is Apis enterococcus faecalis (Enterococcus faecium) or enterococcus faecalis (Enterococcusfaecalis).
Preferred embodiment according to probiotics powder composition of the present invention and probiotic composition is described, and wherein utilizing with the oils and fats of doing the thalline embedding for example be middle chain fatty, Petiolus Trachycarpi oil, soybean lecithin, tea polyphenols, interfacial agent, cotton fatty oil, sweet cured etc.
Probiotics powder composition of the present invention, utilize intestinal adsorption function and PBMC (human peripheral blood glomus cell) to analyze also and can lower irritated probiotic bacteria, in conjunction with the probiotic bacteria that can suppress the HP bacterium, therefore do the novel bacterial combination of competition discharge of bacteria again with the HP bacterium for adjusting body constitution earlier.
The present invention and utilize oils and fats and probiotic bacteria in thalline embedding mode, but develop stomach juice-resistant and cholate, and adsorbable novel form in intestinal, wherein this oils and fats more can mix with trehalose, sodium alginate, pectin, glycerol.
Probiotic composition of the present invention, employed raw material be simple and easy to obtain and processing procedure simple, have stabilized quality simultaneously, the advantage that is easy to preserve.
The invention has the beneficial effects as follows: probiotics powder composition of the present invention and probiotic composition, have that employed raw material is simple and easy to obtain, the simple advantage of processing procedure, and the probiotic composition of manufacturing has stabilized quality, be easy to preserve, active thalline can fully be retained, and can recover plateau rapidly under gastric acid environment.
Be familiar with this skill personage and understand purpose of the present invention, feature and effect for making,, and cooperate appended graphicly, the present invention is illustrated in detail now by following specific embodiment, illustrate as after.
Description of drawings
Fig. 1 is that preferred embodiment bacterium number in sour environment of probiotic composition of the present invention changes situation;
Fig. 2 is that preferred embodiment pH-value in sour environment of probiotic composition of the present invention changes situation.
The specific embodiment
Hereinafter with reference to relevant indicators, illustrate that according to preferred embodiment of the present invention the symbol of mentioning in the explanation is with reference to legend, for ease of understanding, identical assembly will be illustrated with identical reference marks.
The invention provides a kind of probiotics powder composition, comprise and utilize intestinal adsorption function and PBMC (human peripheral blood glomus cell) analysis and can lower irritated probiotic bacteria, in conjunction with suppressing helicobacter pylori (Helicobacter pylori, also claim the HP bacterium) same or another probiotic bacteria, utilize a little therewith probiotic bacterias of a wall material formula in thalline embedding mode, through lyophilization or vacuum lyophilization, to form probiotics powder composition.
Above-mentioned wall material formula is the mixture of an oils and fats, trehalose, sodium alginate, pectin, glycerol.
Above-mentioned oils and fats is middle chain fatty for example, and chain fatty for example is that Petiolus Trachycarpi oil, soybean lecithin, tea polyphenols, interfacial agent, cotton fatty oil or honey are cured etc. in this.
The present invention more provides a kind of probiotic composition, comprises at least a probiotic bacteria, after probiotic bacteria and oils and fats and the antioxidant emulsifying, and with dissolved epithelium mixing and emulsifying, refill the dosage form that is shaped to soft capsule.Wherein, the source of probiotic bacteria can for example be the mycopowder through the thalline embedding.
Probiotic composition provided by the present invention, can be by having the intestinal adsorption function and lowering a probiotic bacteria powder hypersensitive, in conjunction with suppressing the same of helicobacter pylori or another probiotic bacteria, form probiotics powder composition and oils and fats and antioxidant emulsifying through lyophilization, and with dissolved epithelium emulsifying after, filling forms probiotic composition of the present invention.
Above-mentioned oils and fats is middle chain fatty for example, and chain fatty for example is that Petiolus Trachycarpi oil, soybean lecithin, tea polyphenols, interfacial agent, cotton fatty oil or honey are cured etc. in this.
Above-mentioned probiotic bacteria comprises the Lactobacillus acidophilus (Lactobacillus acidophilus) of genus lactubacillus, short lactobacillus (Lactobacillus brevis), acid kefir milk acidfast bacilli (Lactobacillus fermentum), secondary Lactobacillus casei (Lactobacillus paracasei spp.paracasei), lactobacillus plantarum (Lactobacillus plantarum), rhamnose lactic acid bacteria (Lactobacillus rhamnosus), saliva lactobacillus (Lactobacillus salivarius), lactobacillus gasseri (Lactobacillus gasseri), Switzerland's lactobacillus (Lactobacillus helveticus) or Lactobacillus casei strains such as (Lactobacillus casei).
Above-mentioned probiotic bacteria or be the bifidobacterium (Bifidobacterium bifidum) of Bifidobacterium, microscler bacillus bifidus (Bifidobacterium longum), baby's bifidobacterium (Bifidobacterium infantis), short bifidobacterium (Bifidobacterium breve) or newborn bifidobacterium strains such as (Bifidobacterium lactis).
Above-mentioned probiotic bacteria also can be Apis enterococcus faecalis (Enterococcus faecium) or enterococcus faecalis (Enterococcus faecalis).
Being simply clearly narration, below is the specific implementation method of the preferred embodiment of probiotics powder composition of the present invention and probiotic composition:
Embodiments of the invention 1 utilize Petiolus Trachycarpi oil, cotton fatty oil, honey is cured is raw material, in emulsifying temperature below 40 ℃, after antioxidant, the emulsifying of probiotic bacteria powder, behind dissolved epithelium mixing and emulsifying, carry out filling and become probiotic composition of the present invention, wherein this probiotic bacteria is included as a soft capsule dosage form, and to contain profitable probliotics quantity in this probiotic composition be every g 4.5 * 10
10Bacterium colony generates number (CFU/g).
Probiotic bacteria powder used in the present invention is stored in-20 ℃ of bacterial strain glycerol with one and preserves pipe, with culture fluid by the test tube scale, 1 liter of scale, 20 liters of scale to 600 liter scale acid ferment, progressively carry out the action of the big quantification of thalline (amplification), big quantized sour ferment liquid is with 16,000rpm carry out centrifugal after, collect thalline and carry out embedding, and the thalline after the embedding carried out vacuum lyophilization, water content is reduced to below 4%, the powder of grind into powder granular size 50-80 mesh (mesh), above-mentioned each step detects acid-base value simultaneously when carrying out, microscopy and the metering of bacterium number (comprise probiotic bacteria body number, coliform count and aerobic plate count), not contaminated to guarantee thalline.
If probiotic composition of the present invention is with 1.0 * 10
11(CFU/g) the thalline powder is a raw material, and the probiotic bacteria soft capsule goods probiotic bacteria content of prepared generation can reach 4.5 * 10
10(CFU/g), it serves to show that the activity of probiotic bacteria in preparation can be not destroyed, and 37 ℃ preserved for 4 weeks after, probiotic bacteria content still can be up to 8.3 * 10
9(CFU/g), so this probiotic bacteria has good stable with this dosage form state under 37 ℃, relevant bacterium number changes to please refer to down tabulates shown in one.
Table one, probiotic composition bacterium number of the present invention are maltreated the variation situation.
Process stage probiotic bacteria content (CFU/g)
Probiotic bacteria material powder 1.0 * 10
11
Probiotic composition (soft capsule) 4.5 * 10
10
Probiotic composition (preserving a week for 37 ℃) 3.1 * 10
10
Probiotic composition (preserving for two weeks for 37 ℃) 1.9 * 10
10
Probiotic composition (preserving for three weeks for 37 ℃) 1.1 * 10
10
Probiotic composition (around 37 ℃ of preservations) 8.3 * 10
9
Fig. 1 is that preferred embodiment bacterium number in sour environment of probiotic composition of the present invention changes situation; Fig. 2 is that preferred embodiment pH-value in sour environment of probiotic composition of the present invention changes situation.One preferred embodiment of probiotic composition of the present invention is carried out acid resisting test bacterium number changes and pH-value (pH value) changes result as shown in Figures 1 and 2, this acid resisting test is with the probiotic composition of the present invention (back claims soft capsule) of 1 gram and the probiotic bacteria hard capsule goods (back claims hard capsule) of prior art, place 20 grams, pH value is in 2 the hydrochloric acid solution, add 0.75 milliliter of pepsin (pepsin), in 37 ℃ water bath with the 100rpm oscillation action, timing sampling also detects the pH-value and the probiotics bacterial number thereof of solution, by finding out among Fig. 1 and Fig. 2, soft capsule of the present invention has preferable acid resistance, process is with behind the equal time, can keep the more active probiotic bacteria that has, and pH value of solution can be replied balance at short notice.
In sum, probiotics powder composition of the present invention and probiotic composition have employed raw material and are simple and easy to Obtain, the simple advantage of processing procedure, and the probiotic composition of manufacturing has stable quality, is easy to preserve, Active thalline can fully be retained, and can recover rapidly plateau under gastric acid environment.
The method that the present invention utilizes grease to do the thalline embedding also can protect thalline not to be subject to hydrochloric acid in gastric juice and cholate destroys, tool Widely industry applications is arranged, can fully use in similar preparation.
The present invention also can select the several functions probiotic strain simultaneously, as adding have enteron aisle absorption, lower irritated, The special probiotics strain of the functions such as anti-helicobacter pylori ability is to strengthen probiotics powder composition and probio system The effectiveness of product.
Claims (14)
1, a kind of probiotics powder composition is characterized in that comprising a kind of probiotic bacteria, and it is the probiotic bacteria that utilizes intestinal absorption and can lower allergy, inhibition helicobacter pylori;
Perhaps comprise a kind of probiotic bacteria, it utilizes intestinal absorption and can lower a probiotic bacteria hypersensitive and another kind of probiotic bacteria for a kind of, and it is for suppressing the probiotic bacteria of helicobacter pylori;
And utilize a wall material formula and those probiotic bacterias in thalline embedding mode, form a probiotics powder composition through a lyophilization.
2. probiotics powder composition according to claim 1 is characterized in that described lyophilization comprises vacuum lyophilization and pump type heat lyophilization.
3. probiotics powder composition according to claim 1 is characterized in that described wall material formula is the mixture of an oils and fats, trehalose, sodium alginate, pectin, glycerol.
4. probiotics powder composition according to claim 1 is characterized in that described probiotic bacteria comprises the Lactobacillus acidophilus of genus lactubacillus, short lactobacillus, sour kefir milk acidfast bacilli, secondary Lactobacillus casei, lactobacillus plantarum, rhamnose lactic acid bacteria, saliva lactobacillus, lactobacillus gasseri, Switzerland's lactobacillus or Lactobacillus casei.
5. probiotics powder composition according to claim 1 is characterized in that described probiotic bacteria comprises the bifidobacterium of Bifidobacterium, microscler bacillus bifidus, baby's bifidobacterium, short bifidobacterium or newborn bifidobacterium.
6. probiotics powder composition according to claim 1 is characterized in that described probiotic bacteria comprises Apis enterococcus faecalis or enterococcus faecalis.
7. probiotics powder composition according to claim 3 is characterized in that described oils and fats comprises that middle chain fatty, Petiolus Trachycarpi oil, cotton fatty oil or honey are cured.
8. a probiotic composition comprises at least a probiotic bacteria, after this probiotic bacteria and an oils and fats and the antioxidant emulsifying, and with a dissolved epithelium mixing and emulsifying, refill the dosage form that is shaped to a soft capsule.
9. probiotic composition according to claim 8 is characterized in that described oils and fats comprises that middle chain fatty, Petiolus Trachycarpi oil, cotton fatty oil or honey are cured.
10. probiotic composition according to claim 8, the source that it is characterized in that described probiotic bacteria comprises the mycopowder through the thalline embedding.
11. probiotic composition according to claim 8 is characterized in that described probiotic bacteria comprises the Lactobacillus acidophilus of genus lactubacillus, short lactobacillus, sour kefir milk acidfast bacilli, secondary Lactobacillus casei, lactobacillus plantarum, rhamnose lactic acid bacteria, saliva lactobacillus, lactobacillus gasseri, Switzerland's lactobacillus or Lactobacillus casei.
12. probiotic composition according to claim 8 is characterized in that described probiotic bacteria comprises the bifidobacterium of Bifidobacterium, microscler bacillus bifidus, baby's bifidobacterium, short bifidobacterium or newborn bifidobacterium.
13. probiotic composition according to claim 8 is characterized in that described probiotic bacteria comprises Apis enterococcus faecalis or enterococcus faecalis.
14. probiotic composition according to claim 8 is characterized in that described oils and fats can mix with trehalose, sodium alginate, pectin, glycerol.
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| CNA2007101431705A CN101357143A (en) | 2007-08-03 | 2007-08-03 | Probiotics powder composition and product thereof |
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Cited By (9)
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| CN102613458A (en) * | 2012-04-16 | 2012-08-01 | 广东仙乐制药有限公司 | Probiotics soft capsule and preparation method thereof |
| CN102732468A (en) * | 2012-07-06 | 2012-10-17 | 北京农学院 | Enterococcus faecalis and broad-spectrum antibacterial action thereof |
| CN105124333A (en) * | 2015-09-02 | 2015-12-09 | 曹博雅 | Composition containing probiotics as well as preparation method and application of composition |
| CN105146268A (en) * | 2015-08-28 | 2015-12-16 | 广东帝氏医药生物有限公司 | Herbal probiotic powder and preparation method thereof |
| CN107354097A (en) * | 2017-08-10 | 2017-11-17 | 青岛云溯源健康科技有限公司 | A kind of lactic acid bacteria preservative agent for improving liquid lactic acid bacterium survival rate at normal temperatures and its application |
| CN108741090A (en) * | 2018-08-28 | 2018-11-06 | 安徽谷益生物科技有限公司 | A kind of compound probiotic functional food inhibiting helicobacter pylori |
| WO2020007276A1 (en) * | 2018-07-04 | 2020-01-09 | 中科宜康 (北京) 生物科技有限公司 | Highly active probiotic solid beverage having resistance to helicobacter pylori |
| WO2020063515A1 (en) * | 2018-09-30 | 2020-04-02 | 内蒙古伊利实业集团股份有限公司 | Novel application of lactobacillus paracasei k56 capable of regulating balance of gastrointestinal flora |
| CN112353822A (en) * | 2020-11-18 | 2021-02-12 | 中国药科大学 | Application of lactococcus lactis particles and probiotics in preparation of helicobacter pylori infection resisting medicine |
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- 2007-08-03 CN CNA2007101431705A patent/CN101357143A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613458A (en) * | 2012-04-16 | 2012-08-01 | 广东仙乐制药有限公司 | Probiotics soft capsule and preparation method thereof |
| CN102613458B (en) * | 2012-04-16 | 2013-12-18 | 广东仙乐制药有限公司 | Probiotics soft capsule and preparation method thereof |
| CN102732468A (en) * | 2012-07-06 | 2012-10-17 | 北京农学院 | Enterococcus faecalis and broad-spectrum antibacterial action thereof |
| CN102732468B (en) * | 2012-07-06 | 2014-04-23 | 北京农学院 | Enterococcus faecalis and broad-spectrum antibacterial action thereof |
| CN105146268A (en) * | 2015-08-28 | 2015-12-16 | 广东帝氏医药生物有限公司 | Herbal probiotic powder and preparation method thereof |
| CN105124333A (en) * | 2015-09-02 | 2015-12-09 | 曹博雅 | Composition containing probiotics as well as preparation method and application of composition |
| CN107354097A (en) * | 2017-08-10 | 2017-11-17 | 青岛云溯源健康科技有限公司 | A kind of lactic acid bacteria preservative agent for improving liquid lactic acid bacterium survival rate at normal temperatures and its application |
| CN107354097B (en) * | 2017-08-10 | 2020-08-11 | 青岛云溯源健康科技有限公司 | Lactobacillus preservative for improving survival rate of liquid lactobacillus at normal temperature and application thereof |
| WO2020007276A1 (en) * | 2018-07-04 | 2020-01-09 | 中科宜康 (北京) 生物科技有限公司 | Highly active probiotic solid beverage having resistance to helicobacter pylori |
| CN108741090A (en) * | 2018-08-28 | 2018-11-06 | 安徽谷益生物科技有限公司 | A kind of compound probiotic functional food inhibiting helicobacter pylori |
| WO2020063515A1 (en) * | 2018-09-30 | 2020-04-02 | 内蒙古伊利实业集团股份有限公司 | Novel application of lactobacillus paracasei k56 capable of regulating balance of gastrointestinal flora |
| CN110959865A (en) * | 2018-09-30 | 2020-04-07 | 内蒙古伊利实业集团股份有限公司 | New application of lactobacillus paracasei K56 capable of adjusting gastrointestinal flora balance |
| CN110959865B (en) * | 2018-09-30 | 2021-07-09 | 内蒙古伊利实业集团股份有限公司 | New application of lactobacillus paracasei K56 capable of adjusting gastrointestinal flora balance |
| US11666613B2 (en) | 2018-09-30 | 2023-06-06 | Inner Mongolia Yili Industrial Group Co., Ltd. | Use of Lactobacillus paracasei subsp. paracasei K56 capable of regulating gastrointestinal flora balance |
| CN112353822A (en) * | 2020-11-18 | 2021-02-12 | 中国药科大学 | Application of lactococcus lactis particles and probiotics in preparation of helicobacter pylori infection resisting medicine |
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Application publication date: 20090204 |