CN101347539A - Medicament for treating ache of joint and preparation thereof - Google Patents
Medicament for treating ache of joint and preparation thereof Download PDFInfo
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- CN101347539A CN101347539A CNA2008101371107A CN200810137110A CN101347539A CN 101347539 A CN101347539 A CN 101347539A CN A2008101371107 A CNA2008101371107 A CN A2008101371107A CN 200810137110 A CN200810137110 A CN 200810137110A CN 101347539 A CN101347539 A CN 101347539A
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Abstract
The invention discloses a medicine for treating arthralgia and a preparation method thereof and relates to a medicine for treating ache and a preparation method thereof. The medicine of the invention solves the problem that oral administration in the existing medicines for treating arthralgia have poor pertinence and ache is likely to relapse after withdrawal of external medicines. The medicine of the invention for treating arthralgia is essentially prepared by zanthoxylum micranthum, rhizoma corydalis, artificial musk, frankincense, myrrh, menthol and methyl salicylate; the preparation method includes the following steps: ethanol within the temperature of 55-65 DEG C and with volume concentration of 90 % is used for soaking the medicinal materials; after filtration, filtrate is merged, added with other excipients and menthol, and then is added with ethanol to a fixed amount to obtain the medicine for treating arthralgia; the medicine of the invention has good curative effect on the arthralgia caused by various reasons, and arthralgia does not relapse after withdrawal of the medicine.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of pain and preparation method thereof.
Background technology
The medicine of general therapeutic arthralgia is divided into two kinds of oral medication and external used medicines.There is the defective of specific aim difference in oral drugs; Though external used medicine is with strong points, after the drug withdrawal, pain recurs easily.
Summary of the invention
The present invention is the pain problem of recurrence easily after, the external used medicine drug withdrawal poor for oral drugs specific aim in the medicine that solves existing treatment arthralgia, and a kind of medicine that is used for the treatment of arthralgia and preparation method thereof is provided.
The present invention is used for the treatment of the medicine of arthralgia and is mainly made by 80～88 parts SHUJIAO, 10～12.5 parts Rhizoma Corydalis, 0.03～0.07 part artificial Moschus, 2～3 parts Olibanum, 2～3 parts Myrrha, 8～12 parts Mentholum and 160～180 parts methyl salicylate according to weight portion.The present invention is used for the treatment of the preparation method of the medicine of arthralgia and carries out according to following steps: one, by weight 80～88 parts SHUJIAO is immersed in 520～600 parts the ethanol 4, filters, obtain filtrate A; Two, by weight 10～12.5 parts Rhizoma Corydalis is immersed in 40～50 parts the ethanol 4, filters, obtain liquor B
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 4, filter, obtain liquor B
2, then with liquor B
1And liquor B
2Merge, obtain liquor B; Three, by weight with 0.03～0.07 part artificial Moschus in 20～30 parts ethanol 10～14 hours, filter, obtain liquor C
1, with the medicinal residues that leach in 20～30 parts ethanol 10～14 hours, filter again, obtain liquor C
2, then with liquor C
1And liquor C
2Merge, obtain liquor C; Four, be immersed in 40～50 parts the ethanol 5 after by weight the Myrrha of 2～3 parts Olibanum and 2～3 parts being pulverized, filter, obtain filtrate D
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 5, filter, obtain filtrate D
2, then with filtrate D
1With filtrate D
2Merge, obtain filtrate D; Five, after the filtrate A that above step is obtained, liquor B, liquor C, filtrate D mix, add 8～12 parts Mentholum and 160～180 parts methyl salicylate, adding volumetric concentration again and be 90% ethanol to medicinal liquid gross weight is 900～1200 parts; Promptly obtain being used for the treatment of the medicine of arthralgia; Wherein step 1 used alcoholic acid volumetric concentration to the step 4 is 90%, and temperature is 55～65 ℃.
The present invention be used for the treatment of arthralgia the interpolation of medicine by edible essence regulate the abnormal smells from the patient of medicine, add 1～2 part edible essence according to weight portion.
It is as follows that the present invention is used for the treatment of the effect of the various Chinese medicines of medicine of arthralgia and adjuvant:
1, SHUJIAO has dispelling cold by warming the meridian, the promoting the circulation of blood of dispeling the wind is opened the stasis of blood by wet function, can not only the wind dispelling cold-damp, and can promoting the circulation of blood open the stasis of blood, the gas promoting the circulation of blood is lived, channels and collaterals dredging, and reach the effect of reducing swelling and alleviating pain, the SHUJIAO external can make the local skin blood vessel play reflex dilatation, promote the vigorous of local blood circulation, the skin temperature rise is alleviated and swell and ache;
2, artificial Moschus, the hot perfume (or spice) of its property is walked to scurry, and is very careful, reducing swelling and alleviating pain, promoting blood circulation to restore menstrual flow (Chinese Pharmacopoeia), can " cave of being open to the custom; on reach skin, in go into bone marrow " (" Elementary Medicine "), no Yong Bukai, not having knot does not loose, nothing is closed obstructed, with the external of SHUJIAO compatibility, dredge the meridian passage, open stasis and resolving masses, the reducing swelling and alleviating pain effect is better;
3, Rhizoma Corydalis has and invigorates blood circulation promoting the circulation of QI, analgesic effect.The two reasons of QI and blood are used for pain relieving, can make the smooth blood of gas capable, dissipating blood stasis for subsidence of swelling;
4, Olibanum has QI and blood regulating, and the effect of muscles and tendons relaxing to alleviate pain is used for traumatic injury, and cold-damp numbness is logical, and " book on Chinese herbal medicine converges and says " claims that Olibanum is " falling beats beats for promoting blood circulation by removing wind, the key medicine of muscles and tendons relaxing to alleviate pain, folding muscle and tendon injury bone ... it is special merit that the .. ventilationization stagnates ";
5, Myrrha has blood stasis dispelling, detumescence, analgesic effect, be used for traumatic injury, cold-damp numbness is logical, its " can break stagnated blood, reducing swelling and alleviating pain is strange medicine " (" Elementary Medicine "), Compendium of Material Medica claims " Olibanum is invigorated blood circulation, Myrrha looses blood; so the two will hold concurrently and usefulness the logical internal organs of being advisable, the key medicine of circulation meridians mutually ";
6, Mentholum increases the effect of antalgesic-antipruritic, is used for skin and produces refrigerant sense to ease the pain with uncomfortable;
7, edible essence is regulated the abnormal smells from the patient of medicine;
8, methyl salicylate can increase the permeability of medicine as penetrating agent;
9, ethanol comes out the extracts active ingredients of medicine and has promoted the effect of drug osmotic.
The medicine that the present invention is used for the treatment of arthralgia has the following advantages: 1, medicine analgesic of the present invention is with strong points, and drug effect is fast, cures the back and is difficult for recurrence; 2, medicine of the present invention is applied widely, for the various pathological changes arthritis of treatment wind, cold, wet caused limbs, meridians, internal organs, lumbago and skelalgia, swelling, joint stuffiness, numbness and evident in efficacy, in addition for scapulohumeral periarthritis, stiff neck and frosted certain curative effect arranged to soft tissue injury, traumatic injury, bruise; 3, special with sudden force, the dispelling cold by warming the meridian of medicine, medication place begins heating after five minutes, directly acts on the affected part, can see analgesic effect in ten minutes; 4, external better tolerance, no systemic side effects; 5, unique Technology, efficient Transdermal absorption forms higher drug concentration in the part, avoids complicated internal metabolism processes such as oral drugs liver sausage circulation.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: present embodiment is used for the treatment of the medicine of arthralgia and is mainly made by 80～88 parts SHUJIAO, 10～12.5 parts Rhizoma Corydalis, 0.03～0.07 part artificial Moschus, 2～3 parts Olibanum, 2～3 parts Myrrha, 8～12 parts Mentholum and 160～180 parts methyl salicylate according to weight portion.
What Olibanum in the present embodiment and Myrrha adopted is through the medical material after concocting.
The specific embodiment two: present embodiment is used for the treatment of the medicine of arthralgia and is mainly made by 82～86 parts SHUJIAO, 11～12 parts Rhizoma Corydalis, 0.04～0.06 part artificial Moschus, 2.2～2.8 parts Olibanum, 2.2～2.8 parts Myrrha, 9～11 parts Mentholum and 165～175 parts methyl salicylate according to weight portion.
The specific embodiment three: present embodiment is used for the treatment of the medicine of arthralgia and is mainly made by 84 parts SHUJIAO, 11.5 parts Rhizoma Corydalis, 0.05 part artificial Moschus, 2.5 parts Olibanum, 2.5 parts Myrrha, 10 parts Mentholum and 170 parts methyl salicylate according to weight portion.
The specific embodiment four: the difference of the present embodiment and the specific embodiment one is: be used for the treatment of in the medicine of arthralgia and also contain 1～2 part edible essence.Other is identical with the specific embodiment one.
The specific embodiment five: the medicine that present embodiment is used for the treatment of arthralgia is prepared according to following steps: one, by weight 80～88 parts SHUJIAO is immersed in 520～600 parts the ethanol 4, filters, obtain filtrate A; Two, by weight 10～12.5 parts Rhizoma Corydalis is immersed in 40～50 parts the ethanol 4, filters, obtain liquor B
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 4, filter, obtain liquor B
2, then with liquor B
1And liquor B
2Merge, obtain liquor B; Three, by weight with 0.03～0.07 part artificial Moschus in 20～30 parts ethanol 10～14 hours, filter, obtain liquor C
1, with the medicinal residues that leach in 20～30 parts ethanol 10～14 hours, filter again, obtain liquor C
2, then with liquor C
1And liquor C
2Merge, obtain liquor C; Four, be immersed in 40～50 parts the ethanol 5 after by weight the Myrrha of 2～3 parts Olibanum and 2～3 parts being pulverized, filter, obtain filtrate D
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 5, filter, obtain filtrate D
2, then with filtrate D
1With filtrate D
2Merge, obtain filtrate D; Five, after the filtrate A that above step is obtained, liquor B, liquor C, filtrate D mix, add 8～12 parts Mentholum and 160～180 parts methyl salicylate, adding volumetric concentration again and be 90% ethanol to medicinal liquid gross weight is 900～1200 parts; Promptly obtain being used for the treatment of the medicine of arthralgia; Wherein step 1 used alcoholic acid volumetric concentration to the step 4 is 90%, and temperature is 55～65 ℃.
What Olibanum in the present embodiment and Myrrha adopted is through the medical material behind the Chinese medicine processing.
The specific embodiment six: the difference of the present embodiment and the specific embodiment five is: by weight 82～86 parts SHUJIAO is immersed in the step 1 in 540～580 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment seven: the difference of the present embodiment and the specific embodiment five is: by weight 84 parts SHUJIAO is immersed in the step 1 in 560 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment eight: the difference of the present embodiment and the specific embodiment five is: in the step 2 10.5～12 parts Rhizoma Corydalis is immersed in 42～48 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment nine: the difference of the present embodiment and the specific embodiment five is: in the step 2 11 parts Rhizoma Corydalis is immersed in 45 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment ten: the difference of the present embodiment and the specific embodiment five is: in the step 2 medicinal residues that leach are immersed in 42～48 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 11: the difference of the present embodiment and the specific embodiment five is: in the step 2 medicinal residues that leach are immersed in 45 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 12: the difference of the present embodiment and the specific embodiment five is: in the step 3 0.04～0.06 part artificial Moschus is immersed in 22～28 parts the ethanol 11～13 hours.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 13: the difference of the present embodiment and the specific embodiment five is: in the step 3 0.05 part artificial Moschus is immersed in 25 parts the ethanol 12 hours.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 14: the difference of the present embodiment and the specific embodiment five is: in the step 3 medicinal residues that leach are immersed in 23～27 parts the ethanol 11～13 hours.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 15: the difference of the present embodiment and the specific embodiment five is: in the step 3 medicinal residues that leach are immersed in 25 parts the ethanol 12 hours.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 16: the difference of the present embodiment and the specific embodiment five is: be immersed in after in the step 4 Myrrha of 2.2～2.8 parts Olibanum and 2.2～2.8 parts being pulverized in 42～48 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 17: the difference of the present embodiment and the specific embodiment five is: be immersed in after in the step 4 Myrrha of 2.5 parts Olibanum and 2.5 parts being pulverized in 45 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 18: the difference of the present embodiment and the specific embodiment five is: in the step 4 medicinal residues that leach are immersed in 43～47 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 19: the difference of the present embodiment and the specific embodiment five is: in the step 4 medicinal residues that leach are immersed in 45 parts the ethanol.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 20: the difference of the present embodiment and the specific embodiment five is: add 9～11 parts Mentholum and 165～175 parts methyl salicylate in the step 5.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 21: the difference of the present embodiment and the specific embodiment five is: add 10 parts Mentholum and 170 parts methyl salicylate in the step 5.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 22: the difference of the present embodiment and the specific embodiment five is: the edible essence that adds 1～2 part when adding Mentholum and methyl salicylate in the step 5.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 23: the difference of the present embodiment and the specific embodiment five is: adding ethanol to medicinal liquid gross weight in the step 5 again is 950～1150 parts.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 24: the difference of the present embodiment and the specific embodiment five is: adding ethanol to medicinal liquid gross weight in the step 5 again is 1000～1100 parts.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 25: the difference of the present embodiment and the specific embodiment five is: adding ethanol to medicinal liquid gross weight in the step 5 again is 1050 parts.Other step and parameter are identical with the specific embodiment five.
The specific embodiment 26: the medicine that present embodiment is used for the treatment of arthralgia is prepared according to following steps: one, by weight 84 parts SHUJIAO is immersed in 560 parts the ethanol 4, filters, obtain filtrate A; Two, by weight 11.25 parts Rhizoma Corydalis is immersed in 45 parts the ethanol 4, filters, obtain liquor B
1, again the medicinal residues that leach are immersed in 45 parts the ethanol 4, filter, obtain liquor B
2, then with liquor B
1And liquor B
2Merge, obtain liquor B; Three, by weight with 0.05 part artificial Moschus in 25 parts ethanol 12 hours, filter, obtain liquor C
1, with the medicinal residues that leach in 25 parts ethanol 12 hours, filter again, obtain liquor C
2, then with liquor C
1And liquor C
2Merge, obtain liquor C; Four, be immersed in 45 parts the ethanol 5 after by weight the Myrrha of 2.5 parts Olibanum and 2.5 parts being pulverized, filter, obtain filtrate D
1, again the medicinal residues that leach are immersed in 45 parts the ethanol 5, filter, obtain filtrate D
2, then with filtrate D
1With filtrate D
2Merge, obtain filtrate D; Five, after the filtrate A that above step is obtained, liquor B, liquor C, filtrate D mix, add 10 parts Mentholum, 175 parts methyl salicylate and 1.5 parts edible essence, adding volumetric concentration again and be 90% ethanol to medicinal liquid gross weight is 1100 parts; Promptly obtain being used for the treatment of the medicine of arthralgia; Wherein step 1 used alcoholic acid volumetric concentration to the step 4 is 90%, and temperature is 60 ℃.
What Olibanum in the present embodiment and Myrrha adopted is through the medical material behind the Chinese medicine processing.
Giving the patient that different reasons cause arthralgia with the medicine that is used for the treatment of arthralgia of present embodiment preparation treats, the medicine of present embodiment is applied to patient's grieved joint, every day 3～4 times, therapeutic outcome is as shown in table 1, wherein pain symptom obviously alleviates to effectively, painless for curing when pain disappearance and joint motion, pain symptom does not have to be alleviated to invalid.
Table 1
From the data of table 1 as can be seen, the arthralgia that the medicine of present embodiment preparation causes a variety of causes all has good therapeutic effect, and total effective rate is up to 96.44%.Patient after curing was checked after drug withdrawal half a year, all do not have rebound phenomenon.
Claims (10)
1, a kind of medicine that is used for the treatment of arthralgia is characterized in that the medicine that is used for the treatment of arthralgia mainly made by 80～88 parts SHUJIAO, 10～12.5 parts Rhizoma Corydalis, 0.03～0.07 part artificial Moschus, 2～3 parts Olibanum, 2～3 parts Myrrha, 8～12 parts Mentholum and 160～180 parts methyl salicylate according to weight portion.
2, a kind of medicine that is used for the treatment of arthralgia according to claim 1 is characterized in that the medicine that is used for the treatment of arthralgia mainly made by 82～86 parts SHUJIAO, 11～12 parts Rhizoma Corydalis, 0.04～0.06 part artificial Moschus, 2.2～2.8 parts Olibanum, 2.2～2.8 parts Myrrha, 9～11 parts Mentholum and 165～175 parts methyl salicylate according to weight portion.
3, a kind of medicine that is used for the treatment of arthralgia according to claim 1 is characterized in that being used for the treatment of in the medicine of arthralgia and also contains 1～2 part edible essence.
4, a kind of preparation method that is used for the treatment of the medicine of arthralgia as claimed in claim 1, it is characterized in that the medicine that is used for the treatment of arthralgia is prepared according to following steps: one, by weight 80～88 parts SHUJIAO is immersed in 520～600 parts the ethanol 4, filter, obtain filtrate A; Two, by weight 10～12.5 parts Rhizoma Corydalis is immersed in 40～50 parts the ethanol 4, filters, obtain liquor B
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 4, filter, obtain liquor B
2, then with liquor B
1And liquor B
2Merge, obtain liquor B; Three, by weight with 0.03～0.07 part artificial Moschus in 20～30 parts ethanol 10～14 hours, filter, obtain liquor C
1, with the medicinal residues that leach in 20～30 parts ethanol 10～14 hours, filter again, obtain liquor C
2, then with liquor C
1And liquor C
2Merge, obtain liquor C; Four, be immersed in 40～50 parts the ethanol 5 after by weight the Myrrha of 2～3 parts Olibanum and 2～3 parts being pulverized, filter, obtain filtrate D
1, again the medicinal residues that leach are immersed in 40～50 parts the ethanol 5, filter, obtain filtrate D
2, then with filtrate D
1With filtrate D
2Merge, obtain filtrate D; Five, after the filtrate A that above step is obtained, liquor B, liquor C, filtrate D mix, add 8～12 parts Mentholum and 160～180 parts methyl salicylate, adding volumetric concentration again and be 90% ethanol to medicinal liquid gross weight is 900～1200 parts; Promptly obtain being used for the treatment of the medicine of arthralgia; Wherein step 1 used alcoholic acid volumetric concentration to the step 4 is 90%, and temperature is 55～65 ℃.
5, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is characterized in that in the step 1 by weight 82～86 parts SHUJIAO is immersed in 540～580 parts the ethanol.
6, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is characterized in that in the step 2 medicinal residues that leach are immersed in 42～48 parts the ethanol.
7, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is characterized in that in the step 3 medicinal residues that leach are immersed in 23～27 parts the ethanol 11～13 hours.
8, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is immersed in after it is characterized in that in the step 4 Myrrha of 2.5 parts Olibanum and 2.5 parts pulverized in 45 parts the ethanol.
9, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is characterized in that in the step 4 medicinal residues that leach are immersed in 45 parts the ethanol.
10, a kind of preparation method that is used for the treatment of the medicine of arthralgia according to claim 4 is characterized in that adding in the step 5 10 parts Mentholum and 170 parts methyl salicylate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101371107A CN101347539A (en) | 2008-09-12 | 2008-09-12 | Medicament for treating ache of joint and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101371107A CN101347539A (en) | 2008-09-12 | 2008-09-12 | Medicament for treating ache of joint and preparation thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101347539A true CN101347539A (en) | 2009-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101371107A Pending CN101347539A (en) | 2008-09-12 | 2008-09-12 | Medicament for treating ache of joint and preparation thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895333A (en) * | 2012-10-30 | 2013-01-30 | 冯悦 | Chinese medicinal preparation for treating soft tissue injury |
| CN103479759A (en) * | 2012-09-10 | 2014-01-01 | 薛华妮 | Preparation method of emulsifiable paste for physinatherapy |
| CN109925409A (en) * | 2019-04-12 | 2019-06-25 | 陈培 | Muscle arthrosis dredging collateral cream |
-
2008
- 2008-09-12 CN CNA2008101371107A patent/CN101347539A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479759A (en) * | 2012-09-10 | 2014-01-01 | 薛华妮 | Preparation method of emulsifiable paste for physinatherapy |
| CN103479759B (en) * | 2012-09-10 | 2014-11-05 | 辛建伟 | Preparation method of emulsifiable paste for physinatherapy |
| CN102895333A (en) * | 2012-10-30 | 2013-01-30 | 冯悦 | Chinese medicinal preparation for treating soft tissue injury |
| CN109925409A (en) * | 2019-04-12 | 2019-06-25 | 陈培 | Muscle arthrosis dredging collateral cream |
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Open date: 20090121 |