CN101347530B - Oral liquid for regulating blood fat and blood sugar - Google Patents
Oral liquid for regulating blood fat and blood sugar Download PDFInfo
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- CN101347530B CN101347530B CN2008101962499A CN200810196249A CN101347530B CN 101347530 B CN101347530 B CN 101347530B CN 2008101962499 A CN2008101962499 A CN 2008101962499A CN 200810196249 A CN200810196249 A CN 200810196249A CN 101347530 B CN101347530 B CN 101347530B
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Abstract
The invention relates to an oral liquid for regulating blood-fat and blood sugar; the oral liquid is prepared by cassia seed extract and hawthorn extract which are extracted by alcohol extracting and water precipitating and chromium yeast with purified water; each liter of the oral liquid contains 0.4-0.6kg of cassia seed extract, 0.3-0.4kg of hawthorn extract, and 8-15g of chromium yeast. Provedby animal experiments, the oral liquid can regulate the blood-fat and blood sugar of test rats and test mice; the clinical feeding trials show that the fasting blood-glucose of type II diabetic patients reduces by average 2.32mmol/L after a patient takes the oral liquid for one month, and the total effective rate reaches over 90%; furthermore, the oral liquid can alleviate the main clinical symptoms such as polydipsia, pleophagy, polyuria, hypodynamia, and the like, and has no adverse effect on the liver function and the renal function of patients.
Description
One, technical field
The present invention relates to a kind of health food, particularly a kind of health care oral liquid, specifically a kind of oral liquid with blood lipid regulation and blood sugar regulation effect.
Two, background technology
Along with improving constantly of The development in society and economy and people's living standard, higher fatty acid, the diet of high heat and busy work make the sickness rate of China's hyperglycemia, hyperlipidemia more and more high.China's blood sugar regulation, blood lipid regulation are at present mainly with compositions such as spirulina, Fructus Crataegi, Semen Cassiae, Flos Carthami, Fructus Hippophae, Radix Glycyrrhizaes, adopt different processing methods to make tablet or capsule, the energy blood fat reducing, reduce serum total cholesterol, remove the blood vessel wall cholesterol, alleviate atherosclerosis, suppress lipid peroxidation, improve immunity of organism and regulate the nutritive equilibrium state; Or adopt single modernized biological product-chromium yeast auxotype additive.
The sky that Wuhan City's gold Hypon biological product company limited is developed flies a board gold Hypon oral liquid, is that primary raw material is made by Radix et Rhizoma Rhei (processed), Fructus Crataegi, Folium Nelumbinis, Fructus Lycii, Semen Cassiae, Radix Polygoni Multiflori Preparata, and suitable crowd is the higher person of blood fat.The Caulis Entadae board sky arteries and veins oral liquid of Guangdong Yuelong Pharmaceutical Co., Ltd and the limited public responsible company of Zhengzhou Milky Way Pharmaceutical Development and Production, by Fructus Crataegi, Fructus Hordei Germinatus, Fructus Momordicae charantiae, xylitol, purified water is that primary raw material is made, and suitable crowd is the higher person of blood fat, the higher person of blood glucose.The honor arteries and veins fat board gynostemium pentaphylla oral liquid that Jiangxi Prov. Medicine Inst and Jiangxi Ning Gang natural health-care beverage factory develop is that primary raw material is made by Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Semen Cassiae, Fructus Crataegi, Fructus Lycii, Flos Chrysanthemi, cyclamate, the suitable higher person of crowd's blood fat.The easypro thirsty oral liquid of the Onlly of Only Co., Ltd., Shanghai Jiantong Univ.'s development, primary raw material is medicine-food two-purpose Chinese herbal medicine such as Radix Glehniae, Fructus Crataegi, Rhizoma Dioscoreae, Rhizoma Phragmitis, product has the health-care effect of blood sugar regulation.
The disclosed Maikary oral liquor of CN1515280A is made up of following main materials: Limax 10-100 weight portions, snail ovum 10-100 weight portions, rice vinegar 500-2000 weight portions.Can also be added with Semen Cassiae 20-200 weight portions in the described primary raw material, Fructus Lycii 10-100 weight portions, Flos Chrysanthemi 20-200 weight portions, Fructus Crataegi 10-100 weight portions.Advantage of the present invention: scalable blood fat, blood pressure regulation, recovery health, be a kind of good nutriment, without any side effects.
CN1325088C discloses a kind of oral administration liquor for reducing blood fat that is used for the treatment of hyperlipemia, form by Fructus Crataegi cuneatae 30 grams, Radix Puerariae 15 grams, Semen Cassiae 15 grams, Rhizoma Alismatis 15 grams, Folium Ginkgo 10 grams, Fructus Crataegi cuneatae, Radix Puerariae, Semen Cassiae, Rhizoma Alismatis, Folium Ginkgo are ground the end jointly, put into extraction pot and add 10 kilograms of filtrations of height Chinese liquor, adding crystal sugar dissolves, not stopping stirs is oral administration liquor for reducing blood fat, has blood fat reducing, antiatherogenic function, with after have no side effect, the clinic trial effective percentage reaches more than 90%, makes hypertension drop to normal value in the short time.
CN1096686A discloses a kind of efficient phospholipid nutrient oral liquor, it is to be major ingredient with the soybean phospholipid, add that VE and unsaturated fatty acid mix, adjuvant is Fructus Crataegi, Semen Cassiae, add water boil, leach slag and stay juice, adjuvant juice and major ingredient mix, and add essence, promptly get product through dispersion, filtration, homogenizing, packing, sterilization, check again.This product can make the middle-older patient blood fat reducing, reduces blood viscosity, and the prevention of arterial sclerosis reaches the danger of prophylactic treatment cardiovascular disease and releasing cerebral thrombosis.
" Jilin agricultural rural economy information " 2005 (8)-19 discloses a kind of chromium yeast auxotype additive, can be applicable to the medicines and health protection field, to the effective blood sugar lowering of diabetics; Also can be applicable to field of fodder, can increase the lean meat ratio of domestic animal, improve milk yield of cattle and sheep and the egg production of domestic animal.This Harbin City's brainstorm project " bioanalysis prepares the pilot scale research of rare earth organic chromium feed addictive " by " Harbin Institute of Technology " development is identified by province Science and Technology Department.Expert group is thought, adopts the method for adding LREE in the culture medium to promote the formation of organic chromium, has obtained breakthrough achievement.
Three, summary of the invention
The present invention is intended to provide for the public oral liquid of a kind of scalable blood fat and blood glucose, and technical problem to be solved is an optimization formula, not only scalable blood fat but also scalable blood glucose.
Technical scheme of the present invention is to extract Semen Cassiae with the oral liquid that active component in the Fructus Crataegi (calling extract in the following text) and chromium yeast dispose with purified water with ethanol extract from water precipitation, contains 0.4-0.6kg Semen Cassiae extract, 0.3-0.4kg Fructus Crataegi extract and 8-15g chromium yeast in every liter of oral liquid.
Contain 0.40-0.52kg Semen Cassiae extract, 0.30-0.36kg Fructus Crataegi extract and 8.0-12g chromium yeast in preferred every liter of oral liquid.
Further contain 0.46kg Semen Cassiae extract, 0.33kg Fructus Crataegi extract and 10g chromium yeast in preferred every liter of oral liquid.
Ethanol extract from water precipitation is to extract one of Chinese herbal medicine active component traditional method.Be exactly at first to use 80%-85% ethanol that Semen Cassiae and Fructus Crataegi are carried out reflux, extract, in this application, obtain ethanol extract, slough ethanol then and obtain concentrated solution, add 3 times of water in concentrated solution, air agitation 30 minutes cools to 12-15 ℃, static placement is after 18-30 hours, separate with centrifuge, remove floating thing and precipitate and obtain clear liquid (aqueous extract) after the processing of Semen Cassiae and Fructus Crataegi, this aqueous extract is used for preparing oral liquid.
This oral liquid detects through the disease prevention and control center, Anhui Province, the result following (examining report numbering: 07BSWO426L):
Test item unit's testing result operative norm
[1] pH value-4.62 4.2～5.8
[2] plumbous (in Pb) mg/L＜0.25≤0.5
[3] arsenic (in As) mg/L 0.042≤0.3
[4] organic chromium is (with Cr
3+) μ g/100ml 183.2 〉=160 ± 25%
[5] total chromium (in Cr) mg/L 1.834≤2.0
[6] total solid % 13.3 〉=3
[7] total flavones mg/100mL 500 〉=112.
This oral liquid carries out blood lipid regulation effect food function by Nanjing railway hospital analyzing and testing center by " the health food function assessment is estimated and the method for inspection " and learns detection.Examining report (report number: conclusion (food) searching 990036-2 number) is:
1, the experimental rat body weight there is not influence.
2, experimental rat serum total cholesterol (TCHO) there is not influence.
3, when 5ml/kg.BW (be equivalent to human body recommended intake 5 times) and above dosage, has the effect that reduces experimental rat serum triglycerides (TG).
4, when 10ml/kg.BW (quite human body recommended intake 10 times) and above dosage, have and increase (the effect of HDL-C) of experimental rat serum high-density LP cholesterol.
In a word, this oral liquid has the effect of blood lipid regulation when 5ml/kg.BW.
This oral liquid carries out blood sugar regulation effect food function by Nanjing Medical University's nutrition and Food Science technical research institute by " the health food function assessment is estimated and method of inspection " and learns detection.Examining report (report number: 0990041) conclusion is:
This oral liquid gives back mensuration fasting glucose with 5ml/kg.BW, 10ml/kg.BW and three other dosage of level of 30ml/kg.BW to normal mouse and hyperglycemia model mice filling in continuous 30 days stomach, and the result shows that normal mouse fasting glucose and carbohydrate tolerance are not had influence; To the mice diabetic model group that alloxan is made, three kinds of dosage all have the effect that reduces the mice fasting glucose and improve the carbohydrate tolerance level.Show that this oral liquid has the effect of blood sugar regulation.
This oral liquid carries out clinical blood sugar regulation human feeding trial by Nanjing Medical University's nutrition and Food Science technical research institute and Nanjing Medicine University subsidiary Nanjing first hospital by " the health food function assessment is estimated and the method for inspection ". result of the test:
1, after 30 routine type ii diabetes patients take one month, the fasting glucose 2.32mmol/L that on average descends, wherein produce effects 5 examples account for 16.7%, and effective 22 examples account for 73.3%, total effective rate 90.0%, and the blood glucose after two hours after the meal also obviously reduces.
2, the polydipsia that type ii diabetes is suffered from, polyphagia, polyuria, main clinic symptoms such as weak have some improvement.
3, do not see untoward reaction during the test-meal, and erythrocyte, leukocyte, hemoglobin, total serum protein, albumin, glutamate pyruvate transaminase, creatinine, blood urea nitrogen etc. show that all in normal range liver, the stomach function to the people has no adverse effects before and after the test-meal.
Conclusion is that this oral liquid has the blood sugar regulation effect to the type ii diabetes patient,
Four, the specific embodiment
Be example to process 100 liters of oral liquids now, non-limiting examples is described below:
1, depends on that pine torch 40kg rejects foreign body, clean silt, dry naturally, get Fructus Crataegi 30kg, reject foreign body.Semen Cassiae and Fructus Crataegi are dropped in the reflux, extract, jar, add the 80%-85% alcoholic solution, medical material is immersed in the alcoholic solution and gets final product.Soaked 2-3 hour earlier, temperature rising reflux extracted 2-3 hour again, reflux finish after, refrigerated separation, medicinal residues reuse 83%-85% alcoholic solution reflux, extract, at least once, merging filtrate obtains ethanol extract.The ethanol extract vacuum is sloughed ethanol, obtains concentrated solution,
Add the water of about 3 times of volumes in concentrated solution, air agitation 30 minutes cools to 13 ℃, leave standstill 18-30 hours after, isolated by filtration obtains the primary water extracting solution.
Aqueous extract is diluted to 100 liters with purified water, adds the 0.8kg chromium yeast simultaneously and stir and just obtain oral liquid.
2, depend on pine torch 60kg, Fructus Crataegi 40kg, chromium yeast 1.5kg, process 100 liters of oral liquids, processing method use-case 1.
3, depend on pine torch 40kg, Fructus Crataegi 36kg, chromium yeast 1.2kg, process 100 liters of oral liquids, processing method use-case 1.
4, depend on pine torch 52kg, Fructus Crataegi 30kg, chromium yeast 1kg, process 100 liters of oral liquids, processing method use-case 1.
5, depend on pine torch 46kg, Fructus Crataegi 33kg, chromium yeast 1kg, process 100 liters of oral liquids, processing method use-case 1.
Claims (3)
1. a blood lipid regulation, blood glucose oral liquid, be to extract the Semen Cassiae obtain and the extract in the Fructus Crataegi and chromium yeast with the oral liquid that purified water disposes, it is characterized in that: contain 0.4-0.6kg Semen Cassiae extract, 0.3-0.4kg Fructus Crataegi extract and 8-15g chromium yeast in every liter of oral liquid by ethanol extract from water precipitation.
2. oral liquid according to claim 1 is characterized in that: contain 0.40-0.52kg Semen Cassiae extract, 0.30-0.36kg Fructus Crataegi extract and 8-12g chromium yeast in every liter of oral liquid.
3. according to claim 1 or 2 described oral liquids, it is characterized in that: contain 0.46kg Semen Cassiae extract, 0.33kg Fructus Crataegi extract and 10g chromium yeast in every liter of oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101962499A CN101347530B (en) | 2008-08-26 | 2008-08-26 | Oral liquid for regulating blood fat and blood sugar |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101962499A CN101347530B (en) | 2008-08-26 | 2008-08-26 | Oral liquid for regulating blood fat and blood sugar |
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| CN101347530A CN101347530A (en) | 2009-01-21 |
| CN101347530B true CN101347530B (en) | 2011-09-14 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102119772B (en) * | 2011-01-26 | 2015-04-08 | 深圳市多微生保健食品有限公司 | Health oral liquid and preparation method thereof |
| CN108452229A (en) * | 2018-03-02 | 2018-08-28 | 宋彦霖 | Assist blood fat reducing preparation |
| CN109329689A (en) * | 2018-11-12 | 2019-02-15 | 天津市农业生物技术研究中心 | A kind of health solid beverage and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070343A (en) * | 1992-09-05 | 1993-03-31 | 刚丕寰 | The preparation method of beverage with fat-reducing function |
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
-
2008
- 2008-08-26 CN CN2008101962499A patent/CN101347530B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070343A (en) * | 1992-09-05 | 1993-03-31 | 刚丕寰 | The preparation method of beverage with fat-reducing function |
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
Non-Patent Citations (2)
| Title |
|---|
| 庞文贞.富铬酵母调节血糖血脂的作用.《解放军预防医学杂志》.2000,第18卷(第5期),387-390. * |
| 李基洪等.山楂叶、决明子疗效保健饮料的研制.《广州食品工业科技》.2002,第18卷(第3期),27，35. * |
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Owner name: ANHUI PROVINCE HUAXIN BIOLOGY PHARMACY CO., LTD. Free format text: FORMER OWNER: ZHU HUIQIU Effective date: 20100115 |
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Effective date of registration: 20100115 Address after: Anhui Province Jieshou City Zhongyuan Road No. 439 post encoding: 236500 Applicant after: Anhui Huaxin Natural Medicine Co., Ltd. Address before: Anhui Province Jieshou City Zhongyuan Road No. 439 post encoding: 236500 Applicant before: Zhu Huiqiu |
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Denomination of invention: Oral liquid for regulating blood fat and blood sugar Effective date of registration: 20150911 Granted publication date: 20110914 Pledgee: The development of small and medium-sized enterprises financing Company Limited by Guarantee Jieshou City Pledgor: Anhui Huaxin Natural Medicine Co., Ltd. Registration number: 2015990000772 |
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Date of cancellation: 20161020 Granted publication date: 20110914 Pledgee: The development of small and medium-sized enterprises financing Company Limited by Guarantee Jieshou City Pledgor: Anhui Huaxin Natural Medicine Co., Ltd. Registration number: 2015990000772 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Oral liquid for regulating blood fat and blood sugar Effective date of registration: 20161020 Granted publication date: 20110914 Pledgee: The development of small and medium-sized enterprises financing Company Limited by Guarantee Jieshou City Pledgor: Anhui Huaxin Natural Medicine Co., Ltd. Registration number: 2016990000886 |
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Date of cancellation: 20171211 Granted publication date: 20110914 Pledgee: The development of small and medium-sized enterprises financing Company Limited by Guarantee Jieshou City Pledgor: Anhui Huaxin Natural Medicine Co., Ltd. Registration number: 2016990000886 |