CN101343248A - 一种盐酸多奈哌齐关键中间体的精制方法 - Google Patents
一种盐酸多奈哌齐关键中间体的精制方法 Download PDFInfo
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- CN101343248A CN101343248A CN 200810212668 CN200810212668A CN101343248A CN 101343248 A CN101343248 A CN 101343248A CN 200810212668 CN200810212668 CN 200810212668 CN 200810212668 A CN200810212668 A CN 200810212668A CN 101343248 A CN101343248 A CN 101343248A
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Description
实施例 | 化合物I | 化合物II | 化合物I异构体 |
粗品 | 70.4 | 26.41 | 0.99 |
1 | 96.28 | 0.31 | 2.79 |
2 | 97.13 | 0.36 | 1.35 |
3 | 97.44 | 0.18 | 1.61 |
4 | 97.65 | 0.47 | 1.5 |
5 | 96.32 | 0.20 | 2.48 |
6 | 96.82 | 0.41 | 2.10 |
7 | 99.10 | 0.10 | 0.31 |
8 | 92.29 | 2.10 | 0.71 |
9 | 97.71 | 0.47 | 0.34 |
10 | 97.10 | 0.83 | 1.10 |
11 | 96.31 | 0.91 | 2.13 |
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CN101343248A true CN101343248A (zh) | 2009-01-14 |
CN101343248B CN101343248B (zh) | 2012-02-29 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102643224A (zh) * | 2012-05-14 | 2012-08-22 | 南通大学 | 一种光稳定剂及中间体4-丙酮基-1,2,2,6,6-五甲基哌啶的制备方法 |
CN111499560A (zh) * | 2020-05-04 | 2020-08-07 | 山东华霖药业有限公司 | 一种盐酸多奈哌齐关键中间体化合物的纯化方法 |
CN114105862A (zh) * | 2020-08-29 | 2022-03-01 | 浙江华海药业股份有限公司 | 盐酸多奈哌齐杂质及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100422148C (zh) * | 2003-02-27 | 2008-10-01 | 天津药物研究院 | 工业化生产盐酸多奈哌齐的工艺方法 |
EP1741701A4 (en) * | 2004-04-28 | 2010-05-12 | Eisai R&D Man Co Ltd | PROCESS FOR THE PRODUCTION OF 1-BENZYL-4-¬ (5,6-DIMETHOXY-1INDANON) -2-YL METHYLPIPERIDINE AND HYDROCHLORIDE THEREOF |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102643224A (zh) * | 2012-05-14 | 2012-08-22 | 南通大学 | 一种光稳定剂及中间体4-丙酮基-1,2,2,6,6-五甲基哌啶的制备方法 |
CN102643224B (zh) * | 2012-05-14 | 2014-08-13 | 南通大学 | 一种光稳定剂及中间体4-丙酮基-1,2,2,6,6-五甲基哌啶的制备方法 |
CN111499560A (zh) * | 2020-05-04 | 2020-08-07 | 山东华霖药业有限公司 | 一种盐酸多奈哌齐关键中间体化合物的纯化方法 |
CN114105862A (zh) * | 2020-08-29 | 2022-03-01 | 浙江华海药业股份有限公司 | 盐酸多奈哌齐杂质及其制备方法 |
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CN101343248B (zh) | 2012-02-29 |
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Effective date of registration: 20171020 Address after: 317024 flood bridge, Linhai City, Zhejiang Co-patentee after: Shanghai Aobo Biomedicine Techn Co., Ltd. Patentee after: Zhejiang Huahai Pharmaceutical Co., Ltd. Address before: 317024 Development Zone of Linhai bridge, Linhai City, Zhejiang Patentee before: Zhejiang Huahai Pharmaceutical Co., Ltd. |
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Address after: 317024 flood bridge, Linhai City, Zhejiang Patentee after: ZHEJIANG HUAHAI PHARMACEUTICAL Co.,Ltd. Patentee after: Shanghai Aobo biomedical Co.,Ltd. Address before: 317024 flood bridge, Linhai City, Zhejiang Patentee before: ZHEJIANG HUAHAI PHARMACEUTICAL Co.,Ltd. Patentee before: Shanghai Aobo Biomedical Technology Co.,Ltd. |