CN101342267B - Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same - Google Patents
Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same Download PDFInfo
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- CN101342267B CN101342267B CN200810030388A CN200810030388A CN101342267B CN 101342267 B CN101342267 B CN 101342267B CN 200810030388 A CN200810030388 A CN 200810030388A CN 200810030388 A CN200810030388 A CN 200810030388A CN 101342267 B CN101342267 B CN 101342267B
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- Prior art keywords
- corii asini
- colla corii
- portions
- ethanol
- radix
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- 238000000034 method Methods 0.000 title claims abstract description 6
- 239000002245 particle Substances 0.000 title abstract 4
- 241001288870 Angelica polymorpha Species 0.000 title 1
- 108010010803 Gelatin Proteins 0.000 title 1
- 229920000159 gelatin Polymers 0.000 title 1
- 239000008273 gelatin Substances 0.000 title 1
- 235000019322 gelatine Nutrition 0.000 title 1
- 235000011852 gelatine desserts Nutrition 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000009636 Huang Qi Substances 0.000 claims abstract description 16
- 229930006000 Sucrose Natural products 0.000 claims abstract description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 14
- 208000036654 deficiency anemia Diseases 0.000 claims abstract description 11
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims abstract description 10
- 235000013925 ferrous lactate Nutrition 0.000 claims abstract description 10
- 229940037907 ferrous lactate Drugs 0.000 claims abstract description 10
- 239000004225 ferrous lactate Substances 0.000 claims abstract description 10
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000021286 stilbenes Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 230000008569 process Effects 0.000 claims abstract description 4
- 108010052008 colla corii asini Proteins 0.000 claims description 29
- 239000008187 granular material Substances 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000002244 precipitate Substances 0.000 claims description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 10
- 229930003268 Vitamin C Natural products 0.000 claims description 10
- 235000019154 vitamin C Nutrition 0.000 claims description 10
- 239000011718 vitamin C Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 6
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- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
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- 239000000463 material Substances 0.000 claims description 4
- 241000238631 Hexapoda Species 0.000 claims description 3
- 241000607479 Yersinia pestis Species 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000002932 luster Substances 0.000 claims description 3
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- 238000005453 pelletization Methods 0.000 claims description 3
- 238000002203 pretreatment Methods 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 11
- 230000036541 health Effects 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 3
- 206010067482 No adverse event Diseases 0.000 abstract description 2
- 241000125175 Angelica Species 0.000 abstract 3
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 3
- 239000003292 glue Substances 0.000 abstract 3
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- 241000405414 Rehmannia Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
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- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 208000007502 anemia Diseases 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 208000030212 nutrition disease Diseases 0.000 description 1
- 208000019180 nutritional disease Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200810030388A CN101342267B (en) | 2008-08-20 | 2008-08-20 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
Applications Claiming Priority (1)
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CN200810030388A CN101342267B (en) | 2008-08-20 | 2008-08-20 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
Publications (2)
Publication Number | Publication Date |
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CN101342267A CN101342267A (en) | 2009-01-14 |
CN101342267B true CN101342267B (en) | 2010-05-12 |
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CN200810030388A Active CN101342267B (en) | 2008-08-20 | 2008-08-20 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102579598A (en) * | 2011-01-06 | 2012-07-18 | 北京宝德润生医药科技发展有限公司 | Composition used for improving nutritional anaemia and preparation method thereof |
CN102631470A (en) * | 2012-05-05 | 2012-08-15 | 钱家美 | Ejiao Guiqi granules and manufacturing method thereof |
CN105105148A (en) * | 2015-09-23 | 2015-12-02 | 威海紫光金奥力生物技术有限公司 | Method for producing gelatina nigra preparation for improving nutritional anemia |
CN105250996A (en) * | 2015-10-30 | 2016-01-20 | 上海善力健生物科技有限公司 | Biological agent for treating iron-deficiency anemia, preparation method thereof and purpose thereof |
CN115219628A (en) * | 2022-07-19 | 2022-10-21 | 东阿阿胶股份有限公司 | Pretreatment method of compound donkey-hide gelatin slurry and detection method of oligosaccharide in compound donkey-hide gelatin slurry |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1456229A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of donkey hide gelatin effervescent granules for nourishing blood |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1456229A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of donkey hide gelatin effervescent granules for nourishing blood |
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Owner name: GUANGDONG HUANXI BIOLOGICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LI SHAOPING Effective date: 20110613 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 515343 PUNING HUANXI HEALTH FOOD CO., LTD., CHIWEI SUBDISTRICT, PUNING CITY, GUANGDONG PROVINCE TO: 515343 HUANXI INDUSTRIAL PARK, SOUTH SIDE OF CHIWEI TOLL STATION, PUNING CITY, GUANGDONG PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20110613 Address after: 515343 Guangdong city of Puning province ikeo toll station on the south side of West Industrial Park Patentee after: Guangdong Huanxi Biotechnology Co., Ltd. Address before: 515343 Guangdong city of Puning province Puning city of West Street Chi Wei Health Food Co. Ltd. Patentee before: Li Shaoping |
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TR01 | Transfer of patent right |
Effective date of registration: 20180322 Address after: 515326 Jieyang City, Guangdong Province, Puning City, Yun falling village, Yun falling village, the south side of the Guangzhou Shantou Road, Heng de Medicine Co., Ltd., the east side of the 1 first floor of the comprehensive factory building Patentee after: Guangdong Sheng Taihua biopharmaceutical Co., Ltd. Address before: 515343 Guangdong city of Puning province ikeo toll station on the south side of West Industrial Park Patentee before: Guangdong Huanxi Biotechnology Co., Ltd. |
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TR01 | Transfer of patent right |
Effective date of registration: 20200821 Address after: 352200 No. 1 Chengdong North Road, Gutian County, Fujian, Ningde Patentee after: FUJIAN GUTIAN PHARMACEUTICAL Co.,Ltd. Address before: 515326 Jieyang City, Guangdong Province, Puning City, Yun falling village, Yun falling village, the south side of the Guangzhou Shantou Road, Heng de Medicine Co., Ltd., the east side of the 1 first floor of the comprehensive factory building Patentee before: GUANGDONG SHENGTAIHUA BIOLOGICAL PHARMACEUTICAL Co.,Ltd. |
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