CN101322677A - Complexes of hydrolytic collagen protein and avenin and uses thereof - Google Patents
Complexes of hydrolytic collagen protein and avenin and uses thereof Download PDFInfo
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- CN101322677A CN101322677A CNA2008101167872A CN200810116787A CN101322677A CN 101322677 A CN101322677 A CN 101322677A CN A2008101167872 A CNA2008101167872 A CN A2008101167872A CN 200810116787 A CN200810116787 A CN 200810116787A CN 101322677 A CN101322677 A CN 101322677A
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Abstract
The invention relates to a composite of hydrolyzed collagen and avenin with the weight proportion of 0.2-1.0:0.2-1.0. Meanwhile, the invention also provides the application of cream, latex, aqua, jelly, mask and other formulations of the composite in the hand care, feet care, anti-aging, after-sun treatment and hydrating nutritive skin care products. The composite of hydrolyzed collagen and avenin provided by the invention can improve the water holding capability of the skin, enhance the permeability of the skin and increase the content of the collagen in the skin; meanwhile, the composite of the invention can promote the metabolism of the skin, accelerate the healing of wounds and delay the aging of the skin. When the skin care products added with the composite are used, the skin can hold moisture for a long time and become moist and smooth.
Description
Technical field
The invention belongs to skin care field, be specifically related to the complex of a kind of hydrolytic collagen and avenin and the application in skin care item thereof.
Background technology
When weather cold, when dry, it is often too much because of dehydration to be exposed to external skin, and horny layer of epidermis transdermal percentage of water loss is raise.When the moisture content of keratodermatitis less than 10% the time; that skin will become is dry, responsive, follow the string; and then phenomenons such as skin pruritus can appear; even can produce inflammation; these all can quicken the aging of skin, and as can not in time nursing, the barrier protection ability of skin will descend; phenomenon such as occur chapping, hemorrhage is had a strong impact on people's life.
Winter, spring China most of local climate cold, drying; brothers' drying, chap, hemorrhage phenomenon will become extremely general at this moment; brothers' care product of selling on the market; the overwhelming majority reaches skin moisture-keeping and prevents dry and cracked effect by the moisture transmitance that reduces epidermis, but will reduce through the washing this effect to skin care and maintenance in back.
Summary of the invention
The complex that the purpose of this invention is to provide a kind of hydrolytic collagen and avenin.
Another purpose of the present invention provides the application of above-mentioned complex in skin-protection product.
Complex provided by the present invention, the weight ratio of its collagen protein enzymolysis and avenin are 0.2-1.0: 0.2-1.0.
Above-mentioned complex can make that dosage forms such as cream, emulsion, water preparation, gel, facial film are widely used in handguard, protect foot by the conventional method of this area, in the defying age, after-sun restorative, moisture-keeping nutrient skin care item.
The hand cream of above-mentioned complex, it comprises following raw materials by weight percent:
16 octadecanol 4.0-7.0
White mineral oil 3.0-7.0
Isopropyl palmitate 1.0-6.0
Lanoline 0.5-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
Above-mentioned complex protect sufficient frost, it comprises following raw materials by weight percent:
16 octadecanol 4.0-7.0
White mineral oil 3.0-7.0
Isopropyl palmitate 2.0-5.0
Vaseline 0.5-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
The anti-aging cream of above-mentioned complex, it comprises following raw materials by weight percent:
16 octadecanol 4.0-7.0
Silicone oil 1.0-6.0
Sad caprin 2.0-5.0
Ceramide 0.015-2.0
Methyl glucoside ethylene glycol-20 ether sesquistearate 1.0-3.0
Methyl glucoside sesqui-stearate 0.5-2.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
After the solarization of above-mentioned complex Gel mile, it comprises following raw materials by weight percent:
Glycerol 1.0-10.0
Carbomer 0.3-2.0
Triethanolamine 0.3-2.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
The moisture-keeping nutrient frost of above-mentioned complex is characterized in that, comprises following raw materials by weight percent:
16 octadecanol 4.0-7.0
Olive oil 3.0-7.0
Isopropyl palmitate 2.0-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
Wherein, described antiseptic is methyl parahydroxybenzoate class, propyl p-hydroxybenzoate class, benzoic acid, sodium benzoate; Described spice is daily chemical essence.
When the molecular weight of hydrolytic collagen is 3000-5000 dalton, just can be absorbed, and can promote the metabolism of skin by human skin.With exsiccant season, if brothers are dry and cracked, it also can have the effect of promotion to the healing of wound in the winter time.Hydrolytic collagen is pure collagen protein through the decomposition of compound enzyme and gets.It reaches at medicine and is widely used clinically, is used to operation stitching, artificial skin etc.Simultaneously, it has a lot of application in skin care item, and it can promote the synthetic of the interior collagen of skin, replenishes skin collagen.Cure that skin is chapped from the cold, promotes that breach heals, preserves moisture, repairs, whitens, it also plays good skin effect aspect anti-ageing the waiting for a long time.Life-time service, its to human body without any harmful effect.
Avenin is the small molecule active peptide, and molecular weight mainly concentrates on 200-15000 dalton, and contains a large amount of hydrophilic groups.Oat peptide can be absorbed by the direct transdermal of carrier.After being absorbed, in promoting the process of cell proliferation, the competition when it can be eliminated and absorb with amino acid residue (FAA) form between the aminoacid, thus promote proteinicly to synthesize fast.In addition, it also has the active effect of the skin collagen catabolic enzyme MMP-1 (MatrixMetalloproteinase) of inhibition, thereby can increase the content of skin collagen, and can effectively block the great chain reaction of skin damage, and then safeguard that skin structure matter is complete, suppress thinning of skin, increase skin elasticity.
The complex of hydrolytic collagen provided by the invention and avenin, it has following advantage:
1, hydrolytic collagen is as the carrier of avenin, can make avenin see through skin and be absorbed, because the influence of avenin macromolecular mass makes this complex form one deck aquation moisture film at skin, by colloid osmotic pressure, realize effect to skin moisturizing.
2, avenin can suppress the activity of collagen protein catabolic enzyme MMP-1, and the competition when elimination absorbs with amino acid residue (FAA) form between the aminoacid reduces the degraded of collagen protein.Because the similarity of the micromolecule polypeptide structure of hydrolytic collagen and the protein structure of human body, hydrolytic collagen has more permeability to skin, it can promote the synthetic of the interior collagen of skin, replenishes skin collagen, reaches the effect of skin health, elasticity recovery.
3, two kinds of albumen organically combine and combined effect after, skin is had more permeability, have more the effect that replenishes skin collagen, can strengthen the water conservation effect of skin, promote wound healing, help impaired skin maintenance and preserve moisture and antidotal effect, make skin health, elasticity recovery.
Description of drawings
Fig. 1 is a moisture content of skin Corneometer CM825 test result sketch map.
Fig. 2 is that moisture is through the lost Tewameter TM300 test result sketch map of skin.
The specific embodiment
Following examples further specify content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, to modification or the replacement that the present invention did, all belong to scope of the present invention.
Take by weighing the A phase: 16 octadecanol 5.50g, white mineral oil 3.00g, isopropyl palmitate 4.00g, lanoline 2.00g, PEG-100 stearic acid and tristerin 2.50g, methyl hydroxybenzoate 0.15.
Take by weighing the B phase: deionized water 72.70g.
Take by weighing the C phase: hydrolytic collagen and avenin compound 10.00g (hydrolytic collagen powder 0.50g+ avenin powder 0.50g is dissolved in the 9.0g deionized water), propyl p-hydroxybenzoate 0.05g, daily use chemicals rose essence 0.10g.
A phase, B are heated to 80 ℃ mutually respectively, then A are added to the B phase, carried out homogenizing 2 minutes, stir cooling then, be cooled to 50 ℃, add the C phase.Be stirred to 35 ℃, stop stirring and get final product.
Take by weighing the A phase: 16 octadecanol 5.00g, white mineral oil 3.00g, isopropyl palmitate 4.00g, vaseline 2.00g, PEG-100 stearic acid and tristerin 2.50g, methyl hydroxybenzoate 0.15g.
Take by weighing the B phase: deionized water 73.20g.
Take by weighing the C phase: hydrolytic collagen and avenin compound 10.00g (hydrolytic collagen powder 0.50g+ avenin powder 0.50g is dissolved in the 9.00g deionized water), propyl p-hydroxybenzoate 0.05g, daily use chemicals rose essence 0.10g.
A phase, B are heated to 80 ℃ mutually respectively, then A are added to the B phase, carried out homogenizing 2 minutes, stir cooling then, be cooled to 50 ℃, add the C phase.Be stirred to 35 ℃, stop stirring and get final product.
Take by weighing the A phase: 16 octadecanol 7.00g, silicone oil 3.00g, sad caprin 3.00g, methyl glucoside ethylene glycol-20 ether sesquistearate 1.50g, methyl hydroxybenzoate 0.15g.
Take by weighing the B phase: ceramide 0.20g, methyl glucoside sesqui-stearate 1.50g, deionized water 73.50g.
Take by weighing the C phase: hydrolytic collagen and avenin compound 10.00g (hydrolytic collagen powder 0.70g+ avenin powder 0.50g is dissolved in the 8.80g deionized water), propyl p-hydroxybenzoate 0.05g, daily use chemicals rose essence 0.1g.
A phase, B are heated to 80 ℃ mutually respectively, then A are added to the B phase, carried out homogenizing 2 minutes, stir cooling then, be cooled to 50 ℃, add the C phase.Be stirred to 35 ℃, stop stirring and get final product.
The application in Gel mile after solarization of embodiment 4 hydrolytic collagen and avenin complex
Take by weighing the A phase: carbomer 0.50g, glycerol 5.00g, deionized water 83.85g
Take by weighing the B phase: hydrolytic collagen and avenin compound 10.00g (hydrolytic collagen powder 0.50g+ avenin powder 0.50g is dissolved in the 9.00g deionized water).
Take by weighing the C phase: triethanolamine 0.50g, daily use chemicals rose essence 0.10g, benzoic acid 0.05g.
Get the A phase, be heated to 60 ℃ and dissolve fully to raw material, then A is added to the B phase, stir then and be cooled to transparently, be cooled to 50 ℃, add the C phase.Be stirred to 35 ℃, stop stirring and get final product.
Embodiment 5 hydrolytic collagen and the application of avenin complex in the moisture-keeping nutrient frost
Take by weighing the A phase: 16 octadecanol 7.00g, olive oil 4.00g, isopropyl palmitate 3.00g, PEG-100 stearic acid and tristerin 4.00g, methyl hydroxybenzoate 0.15g.
Take by weighing the B phase: deionized water 71.70g.
Take by weighing the C phase: hydrolytic collagen and avenin compound 10.00g (hydrolytic collagen powder 0.70g+ avenin powder 0.50g is dissolved in the 8.8g deionized water), propyl p-hydroxybenzoate 0.05g, daily use chemicals rose essence 0.10g.
Get A phase, B and be heated to 80 ℃ mutually respectively, then A is added to the B phase, carried out homogenizing 2 minutes, stir cooling then, be cooled to 50 ℃, add the C phase.Be stirred to 35 ℃, stop stirring and get final product.
The clinical effectiveness test of experimental example 1 above-mentioned hand cream
Have dry in various degree coarsely with hand, and have more shallow fissured 35 people along the angleplied laminate that dermatoglyph distributes and be experimental subject, wherein, women 25 examples, male 10 examples.Age is from 23-60 year.Experiment lasts 7-20 days.
Using method: be coated with the hand cream of 2-3 embodiment 1 every day outward, and smearing the position is the back of the hand.
Use after 2-3 days skin to begin to become to moisten smooth, uses after 7 days, hand recovers to moisten, gloss, elasticity, the angleplied laminate shallow fracture disappearance that distributes along dermatoglyph account for 32 examples (91%).Use after 14 days, skin all recovers to moisten smooth.
Experimental example 2 above-mentioned hand cream moisture-keeping efficacy research reports
1, experimental principle
The crowd forms test population by particular experiment, the variation of skin moisture content (MMV), moisture of skin lost (TEWL) etc. before and after the hand cream of test subject use embodiment 1, thus determine moisture-keeping efficacy.
2, test environment
Temperature: 19.6 ℃～22 ℃, humidity: 43%～57.2%.
3, experimental apparatus
Moisture content of skin Corneometer CM825 tester
Moisture is through the lost Tewameter TM300 tester of skin
4, experiment crowd, testing time and place
The crowd: 30 people, the age is between 20～52 years old.
Testing time: on March 30,29 days～2008 March in 2008.
Place: plant resources research and development key lab of Beijing Technology and Business University.
5, experimental technique
(1), the experiment before, the experimenter tests the position can not smear any skin care item in two days.And arm is cleaned up, and enter laboratory and sit quietly adjustment skin temperature and humidity half an hour before experiment.The experimenter is in the specified test environment all the time at 4 hours test periods.
(2), the left and right arm of selection experimenter inboard for testing the position, is determined the position of being tried of 4 * 4cm apart from 5 centimeters places of palm base portion.
(3), the experimenter smears the hand cream of embodiment 1 in arm experiment position leftward, right arm experiment position be a blank.
(4), the statistics experimenter test the numerical value that the position records at every turn, analyze the every index Changing Pattern of its skin.
6, interpretation of result
Hand cream is not smeared in the 0h representative, and the 0.5h representative was smeared hand cream 0.5 hour afterwards, by that analogy.
(1) moisture test (Moisture Measurement Value) data are as shown in Figure 1:
1) compare with corresponding blank space after using hand cream 0.5h, moisture has obvious lifting, and sustainable 3h is in higher level.
2) moistening effect is remarkable behind the use hand cream 0.5h, though slightly descend afterwards, compares with blank space and still keeps higher moistening effect.
3) relatively overall, after using hand cream, can keep skin surface moisture abundance, moistening effect is remarkable.
(2) skin moisture scatters and disappears TEWL (Transepidermal Water Loss) data as shown in Figure 2:
1) reducing aspect moisture content scatters and disappears, use hand cream can obviously reduce the skin surface moisture loss.
2) use behind the hand cream 0.5h skin moisture TEWL that scatters and disappears to descend gradually, and compare with blank space after all maintained reduced levels in 3 hours, and the blank space moisture loss is still suitable with 0h.Illustrate that this hand cream has " lock water " effect that continues to keep moisture.
Claims (8)
1, the complex of a kind of hydrolytic collagen and avenin is characterized in that, the weight ratio of collagen protein enzymolysis and avenin is 0.2-1.0: 0.2-1.0.
2, the application of the described complex of claim 1 in the preparation skin care item.
3, application as claimed in claim 2 is characterized in that, the dosage form of described skin care item is cream, emulsion, water preparation, gel, facial film.
4, a kind ofly contain the hand cream that right requires 1 described complex, it is characterized in that, comprise following raw materials by weight percent:
16 octadecanol 4.0-7.0
White mineral oil 3.0-7.0
Isopropyl palmitate 1.0-6.0
Lanoline 0.5-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
5, a kind of right that contains requires the sufficient frost of protecting of 1 described complex, it is characterized in that, comprises following raw materials by weight percent:
16 octadecanol 4.0-7.0
White mineral oil 3.0-7.0
Isopropyl palmitate 2.0-5.0
Vaseline 0.5-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
6, a kind ofly contain the anti-aging cream that right requires 1 described complex, it is characterized in that, comprise following raw materials by weight percent:
16 octadecanol 4.0-7.0
Silicone oil 1.0-6.0
Sad caprin 2.0-5.0
Ceramide 0.015-2.0
Methyl glucoside ethylene glycol-20 ether sesquistearate 1.0-3.0
Methyl glucoside sesqui-stearate 0.5-2.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
7, a kind ofly contain after the solarization that right requires 1 described complex Gel mile, it is characterized in that, comprise following raw materials by weight percent:
Glycerol 1.0-10.0
Carbomer 0.3-2.0
Triethanolamine 0.3-2.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
8, a kind ofly contain the moisture-keeping nutrient frost that right requires 1 described complex, it is characterized in that, comprise following raw materials by weight percent:
16 octadecanol 4.0-7.0
Olive oil 3.0-7.0
Isopropyl palmitate 2.0-5.0
PEG-100 stearic acid and tristerin 2.0-5.0
Hydrolytic collagen and avenin compound 0.3-5.0
Spice is an amount of
Antiseptic is an amount of
Deionized water adds to 100.0.
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Cited By (8)
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| CN101953758B (en) * | 2009-07-21 | 2013-04-03 | 吉林修正药业新药开发有限公司 | Series of skin care products with oat protein peptide as basic component and preparation method thereof |
| CN103040700A (en) * | 2012-12-14 | 2013-04-17 | 吴江市德佐日用化学品有限公司 | Method for preparing hand cream |
| CN103356426A (en) * | 2013-05-26 | 2013-10-23 | 上海珍馨化工科技有限公司 | Peel-off type sanguisorba officinalis sterilizing facial mask and preparation method thereof |
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2761607A1 (en) * | 1997-04-04 | 1998-10-09 | Boots Co Plc | DERMATOLOGICAL COMPOSITION FOR THE TREATMENT OF SKIN AGING SYMPTOMS |
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| CN101953758B (en) * | 2009-07-21 | 2013-04-03 | 吉林修正药业新药开发有限公司 | Series of skin care products with oat protein peptide as basic component and preparation method thereof |
| CN103040700A (en) * | 2012-12-14 | 2013-04-17 | 吴江市德佐日用化学品有限公司 | Method for preparing hand cream |
| CN103356426A (en) * | 2013-05-26 | 2013-10-23 | 上海珍馨化工科技有限公司 | Peel-off type sanguisorba officinalis sterilizing facial mask and preparation method thereof |
| CN103356426B (en) * | 2013-05-26 | 2015-09-23 | 上海珍馨化工科技有限公司 | Exfoliated Radix Sanguisorbae sterilization facial film and preparation method thereof |
| CN103637928A (en) * | 2013-12-13 | 2014-03-19 | 孙锐 | Moisturizing and whitening gel and preparation method |
| CN106109369A (en) * | 2016-06-21 | 2016-11-16 | 广州暨南生物医药研究开发基地有限公司 | A kind of anti-wrinkle composition containing Hibiscus manihot L. and anti-wrinkle cream thereof |
| CN106109369B (en) * | 2016-06-21 | 2018-12-11 | 广州暨南生物医药研究开发基地有限公司 | A kind of anti-wrinkle composition and its anti-wrinkle cream containing Golden flower |
| CN107519035A (en) * | 2017-08-30 | 2017-12-29 | 李伟 | A kind of application of gelatin hydrolysis gelatin compound in skin-protection product |
| CN109984953A (en) * | 2019-05-22 | 2019-07-09 | 宁波御坊堂生物科技有限公司 | A kind of protein peptides take a shower, clean skin gel and preparation method thereof |
| CN109984953B (en) * | 2019-05-22 | 2022-08-19 | 宁波御坊堂生物科技有限公司 | Protein peptide gel for bath and skin cleaning and preparation method thereof |
| CN115414265A (en) * | 2022-08-29 | 2022-12-02 | 中国科学院过程工程研究所 | Composition and face cream with effects of color correction, skin tendering and moisturizing and preparation method thereof |
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Owner name: NEW ERA HEALTH INDUSTRY (GROUP) CO., LTD. Free format text: FORMER OWNER: YANTAI NEW ERA HEALTH INDUSTRY DAILY CHEMICAL CO., LTD. Effective date: 20100729 Owner name: YANTAI NEW ERA HEALTH INDUSTRY DAILY CHEMICAL CO., |
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Effective date of registration: 20100729 Address after: 100101 Beijing science and Technology Park of Changping District Bai Fu Road 10 Beikong science building nine layer Co-patentee after: Yantai Era Health Industry Daily Chemical Co., Ltd. Patentee after: New Age Health Industry(Group) Co., Ltd. Address before: 339, room three, floor 3, zone E, Pioneer Park, Yantai Development Zone, Yantai, Shandong, 264006 Patentee before: Yantai Era Health Industry Daily Chemical Co., Ltd. |